Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DDX19A Gene

protein-coding   GIFtS: 50
GCID: GC16P070380

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A

(Previous name: DEAD (Asp-Glu-Ala-As) box polypeptide 19-like)
(Previous symbol: DDX19L)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A1 2     ATP-Dependent RNA Helicase DDX19A2
DDX19L1 2 3     DEAD (Asp-Glu-Ala-As) Box Polypeptide 19A2
DDX19-Like Protein2 3     RNA Helicase2
DEAD Box Protein 19A2 3     EC 3.6.4.133
DEAD (Asp-Glu-Ala-As) Box Polypeptide 19-Like1     EC 3.6.18
DDX19-DDX19L2     

External Ids:    HGNC: 256281   Entrez Gene: 553082   Ensembl: ENSG000001688727   UniProtKB: Q9NUU73   

Export aliases for DDX19A gene to outside databases

Previous GC identifers: GC16P068940 GC16P056213


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DDX19A Gene:
DDX19A (DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A) is a protein-coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX25.

UniProtKB/Swiss-Prot: DD19A_HUMAN, Q9NUU7
Function: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes,
DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are
dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX19A gene promoter:
         C/EBPbeta   ATF-2   Meis-1b   c-Ets-1   Max   FOXO4   SEF-1 (1)   Meis-1a   Meis-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDX19A promoter sequence
   Search Chromatin IP Primers for DDX19A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX19A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

DDX19A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX19A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P070380:  view genomic region     (about GC identifiers)

Start:
70,380,732 bp from pter      End:
70,407,286 bp from pter
Size:
26,555 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DD19A_HUMAN, Q9NUU7 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX19A  
Size: 478 amino acids; 53975 Da
Secondary accessions: B2RPL0 Q53FM0

Explore the universe of human proteins at neXtProt for DDX19A: NX_Q9NUU7

Explore proteomics data for DDX19A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys63, Lys91, Lys186
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX19A (Q9NUU7) (see all 16)
     FVLDEAD  SPLYSVK  ALCNLYG  VINFDLP 


    See DDX19A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060802.1  
    ENSEMBL proteins: 
     ENSP00000306117   ENSP00000457103   ENSP00000455134   ENSP00000455152   ENSP00000464207  
     ENSP00000456765   ENSP00000410243   ENSP00000460180   ENSP00000399208  

    DDX19A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DDX19A
    OriGene Protein Over-expression Lysate for DDX19A
    OriGene MassSpec for DDX19A
    OriGene Custom Protein Services for DDX19A
    GenScript Custom Purified and Recombinant Proteins Services for DDX19A
    Novus Biologicals DDX19A Protein
    Novus Biologicals DDX19A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX19A

     
    Search eBioscience for Proteins for DDX19A 

     
    antibodies-online proteins for DDX19A (4 products) 

     
    antibodies-online peptides for DDX19A

    DDX19A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DDX19A
    Novus Biologicals DDX19A Antibodies
    Abcam antibodies for DDX19A
    Cloud-Clone Corp. Antibodies for DDX19A
    ThermoFisher Antibodies for DDX19A
    antibodies-online antibodies for DDX19A (10 products) 

    DDX19A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDX19A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDX19A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDX19A
    Cloud-Clone Corp. CLIAs for DDX19A
    Search eBioscience for ELISAs for DDX19A 
    antibodies-online kits for DDX19A (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DDX: DEAD-boxes

    5 InterPro protein domains:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9NUU7

    ProtoNet protein and cluster: Q9NUU7

    UniProtKB/Swiss-Prot: DD19A_HUMAN, Q9NUU7
    Domain: The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the
    N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into
    position for catalysis (By similarity)
    Similarity: Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX19A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DD19A_HUMAN, Q9NUU7
    Function: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes,
    DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are
    dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity)
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with DDX19A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DDX19A:
     G0/1 arrest  Increased G1 DNA content  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DDX19A

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDX19A:
    hsa-mir-31-5p (MIRT049879), hsa-mir-615-3p (MIRT039828), hsa-mir-124-3p (MIRT022423)

    Block miRNA regulation of human, mouse, rat DDX19A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX19A (see all 19):
    hsa-miR-579 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-507 hsa-let-7g hsa-let-7a hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidDDX19A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDX19A
    Predesigned siRNA for gene silencing in human, mouse, rat DDX19A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDX19A

    Clone
    Products:
         
    OriGene clones in human, mouse for DDX19A (see all 7)
    OriGene ORF clones in mouse, rat for DDX19A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX19A (NM_018332)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX19A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX19A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDX19A
    Browse ESI BIO Cell Lines and PureStem Progenitors for DDX19A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX19A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DD19A_HUMAN, Q9NUU7: Cytoplasm (By similarity). Nucleus, nuclear pore complex. Nucleus membrane; Peripheral
    membrane protein; Cytoplasmic side (By similarity). Note=Nuclear pore complex cytoplasmic fibrils
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005643nuclear pore IEA--
    GO:0005737cytoplasm IDA--
    GO:0031965nuclear membrane IEA--

    Find genes that share ontologies with DDX19A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX19A
    Interactions:

        Search GeneGlobe Interaction Network for DDX19A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX19A (Q9NUU72, 3 ENSP000003061174) via UniProtKB, MINT, STRING, and/or I2D (see all 916)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138382, 3, ENSP000003794754MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000379475
    ENSG00000225073Q138382, 3, ENSP000004003264MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000400326
    ENSG00000215425Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000225859Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ENSG00000229496Q138382, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0010043response to zinc ion IEA--
    GO:0015031protein transport IEA--
    GO:0043065positive regulation of apoptotic process IEA--
    GO:0051028mRNA transport IEA--

    Find genes that share ontologies with DDX19A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX19A (DD19A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DDX19A gene: 
    NM_018332.3  

    Unigene Cluster for DDX19A:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A
    Hs.656037  [show with all ESTs]
    Unigene Representative Sequence: AB209401
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302243(uc010cfq.1 uc002eys.3 uc010cfs.3 uc010vlz.2 uc002eyv.3 uc010vma.2)
    ENST00000562509 ENST00000565195 ENST00000569771(uc010cfr.3) ENST00000566167
    ENST00000569244 ENST00000561574 ENST00000562649 ENST00000569319 ENST00000417604
    ENST00000567012 ENST00000575878 ENST00000566574 ENST00000568779 ENST00000562140
    ENST00000443119
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDX19A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX19A (see all 19):
    hsa-miR-579 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-507 hsa-let-7g hsa-let-7a hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidDDX19A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDX19A
    Predesigned siRNA for gene silencing in human, mouse, rat DDX19A
    Clone
    Products:
         
    OriGene clones in human, mouse for DDX19A (see all 7)
    OriGene ORF clones in mouse, rat for DDX19A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX19A (NM_018332)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX19A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX19A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDX19A
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX19A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX19A
      QuantiTect SYBR Green Assays in human, mouse, rat DDX19A
      QuantiFast Probe-based Assays in human, mouse, rat DDX19A

    Additional mRNA sequence: 

    AB209401.1 AK001988.1 AK125701.1 AK223262.1 AK299504.1 AK299539.1 AK310604.1 AK310804.1 
    AK310808.1 AL832901.1 AL832970.1 BC005162.2 BC006544.2 BC137496.1 BC137497.1 CR749227.1 

    23 DOTS entries:

    DT.453128  DT.95266032  DT.120659616  DT.120659682  DT.120659668  DT.70105447  DT.92467020  DT.95230620 
    DT.120659659  DT.95266035  DT.100795833  DT.120659661  DT.120659664  DT.75138910  DT.75153768  DT.91847880 
    DT.95105861  DT.100712757  DT.100795830  DT.101959511  DT.120659573  DT.120659649  DT.438352 

    Selected AceView cDNA sequences (see all 474):

    CR625899 AI382892 BQ887457 AI612876 BM988409 BQ939975 BE019902 BQ650066 
    BG392444 BM918229 CA447721 BQ883412 AI818499 CR594442 BQ680080 BQ680805 
    BC003626 BC025771 AI689353 CB129213 CD367602 AI273565 BM683133 BQ940784 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDX19A (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
    SP1:                                -     -                 -           -     -     -                                             
    SP2:                                -     -                 -           -     -     -                                             
    SP3:                                                        -           -     -     -                                             
    SP4:                                -     -                                                                                       
    SP5:                                -     -                 -                                                                     


    ECgene alternative splicing isoforms for DDX19A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DDX19A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DDX19A Expression
    About this image

    DDX19A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX19A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656037
        Custom PCR Arrays for DDX19A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDX19A
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX19A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX19A
    QuantiTect SYBR Green Assays in human, mouse, rat DDX19A
    QuantiFast Probe-based Assays in human, mouse, rat DDX19A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX19A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX19A gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx19a1 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a1, 5 90.93(n)1
    97.49(a)1
      8 (57.86 cM)5
    136801  NM_007916.21  NP_031942.21 
     1109749965 
    chicken
    (Gallus gallus)
    Aves DDX19B6
    Gallus gallus DEAD (Asp-Glu-Ala-Asp) box polypepti...
    92(a)
    1 → many
    21(4849821-4857034)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1936901 zgc:193690 76.4(n)
    83.58(a)
      563448  NM_001128715.1  NP_001122187.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dbp806
    Dead box protein 80
    52(a)
    1 → many
    3LHet(2409852-2545146)
    worm
    (Caenorhabditis elegans)
    Secernentea ddx-191 ddx-19 56.7(n)
    54.31(a)
      174418  NM_001267257.1  NP_001254186.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP5(YOR046C)4
    DBP51
    Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p less4
    DBP51
    54.14(n)1
    52.09(a)1
      15(415907-414459)4
    8542111, 4  NP_014689.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LOS41 LOS4 49.69(n)
    40.68(a)
      824477  NM_115171.3  NP_190879.1 


    ENSEMBL Gene Tree for DDX19A (if available)
    TreeFam Gene Tree for DDX19A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DDX19A gene
    DDX252  ENSG000002605372  DDX19B2  
    Selected SIMAP similar genes for DDX19A using alignment to 9 protein entries:     DD19A_HUMAN (see all proteins) (see all similar genes):
    DKFZp686C21137    DKFZp762C1313    DDX19L    DDX19B    DDX25    ETFA
    SYNE1    DDX56    ADCY7    L3MBTL2    PAM16    BAT1
    EIF4A3    EIF4A2    DKFZp547B159    MST162    EIF4A1    DDX6

    Find genes that share paralogs with DDX19A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DDX19A (see all 571)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897152321,2
    --70382678(+) TTTCTA/GCAAAA 1 -- int10--------
    rs1134050481,2
    F--70382704(+) GCTGGG/ACGGGG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1383748771,2
    --70382706(+) TGGGCA/GGGGTG 1 -- int10--------
    rs1842721361,2
    C--70382716(+) GGTGGC/TACACT 1 -- int10--------
    rs1884703281,2
    --70382889(+) CTGTTC/GTGAAT 1 -- int10--------
    rs1492528391,2
    C--70382960(+) TTGACA/GATTTG 1 -- int10--------
    rs1818999241,2
    --70383036(+) TACAAA/GGCAAA 1 -- int10--------
    rs1865488131,2
    --70383099(+) TTCCAA/GGTTAT 1 -- int10--------
    rs1905545791,2
    --70383109(+) TCTCCC/TAATGG 1 -- int10--------
    rs72000341,2
    C,F,A,H--70383112(+) cccaaT/Cggagt 1 -- int118Minor allele frequency- C:0.14NS EA NA WA 1914

    HapMap Linkage Disequilibrium report for DDX19A (70380732 - 70407286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DDX19A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714670CNV Deletion23290073
    nsv833272CNV Loss17160897
    nsv7285OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX19A
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX19A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DDX19A gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with DDX19A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P.... Mermoud J.E. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55308 HGNC: 25628 AceView: DDX19andFLJ11126 Ensembl:ENSG00000168872 euGenes: HUgn55308
    ECgene: DDX19A H-InvDB: DDX19A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DDX19A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DDX19A gene:
    Search GeneIP for patents involving DDX19A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DDX19A  
     OriGene qPCR primer pairs and template standards for DDX19A   OriGene Protein Over-expression Lysate for DDX19A  
     OriGene MassSpec for DDX19A   OriGene clones in human, mouse for DDX19A  
     OriGene qSTAR qPCR primer pairs in human, mouse for DDX19A   OriGene Purified Protein for DDX19A  
     OriGene ORF clones in mouse, rat for DDX19A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDX19A   OriGene Custom Protein Services for DDX19A  

     
     
     Block miRNA regulation of human, mouse, rat DDX19A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DDX19A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX19A Predesigned siRNA for gene silencing in human, mouse, rat DDX19A
     QuantiFast Probe-based Assays in human, mouse, rat DDX19A QuantiTect SYBR Green Assays in human, mouse, rat DDX19A
     Custom PCR Arrays for DDX19A Search Chromatin IP Primers for DDX19A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX19A  Search GeneGlobe Interaction Network for DDX19A
     Regulatory tfbs in DDX19A promoter
     GenScript Custom Purified and Recombinant Proteins Services for DDX19A GenScript cDNA clones with any tag delivered in your preferred vector for DDX19A
     GenScript Custom Assay Services for DDX19A GenScript Custom overexpressing Cell Line Services for DDX19A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DDX19A (DD19A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DDX19A antibodies
     DDX19A proteins
     DDX19A lysates
     Antibodies for DDX19A
     See all of Abcam's Antibodies, Kits and Proteins for DDX19A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DDX19A
     Antibodies for DDX19A
     ELISAs for DDX19A
     CLIAs for DDX19A



     Browse ESI BIO Cell Lines and PureStem Progenitors for DDX19A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX19A
     SwitchGear 3'UTR luciferase reporter plasmids for DDX19A
     SwitchGear Promoter luciferase reporter plasmids for DDX19A
     ThermoFisher Antibodies for DDX19A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX19A
     Browse compounds at ApexBio
     Search Addgene for plasmids for DDX19A
      Search eBioscience for proteins for DDX19A
      Search eBioscience for elisas for DDX19A
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DDX19A
     antibodies-online antibodies for DDX19A (10 products)
     antibodies-online kits for DDX19A (6 products)
     antibodies-online peptides for DDX19A
     antibodies-online proteins for DDX19A (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DDX19A gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4