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Aliases for DDX19A Gene

Aliases for DDX19A Gene

  • DEAD-Box Helicase 19A 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A 2 3 5
  • DEAD Box Protein 19A 3 4
  • DDX19-Like Protein 3 4
  • DDX19L 3 4
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19-Like 2
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19A 3
  • RNA Helicase 3
  • DDX19-DDX19L 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DDX19A Gene

Previous HGNC Symbols for DDX19A Gene

  • DDX19L

Previous GeneCards Identifiers for DDX19A Gene

  • GC16P068940
  • GC16P070380
  • GC16P056213
  • GC16P070299

Summaries for DDX19A Gene

GeneCards Summary for DDX19A Gene

DDX19A (DEAD-Box Helicase 19A) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is DDX25.

UniProtKB/Swiss-Prot for DDX19A Gene

  • ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX19A Gene

Genomics for DDX19A Gene

Regulatory Elements for DDX19A Gene

Enhancers for DDX19A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX19A on UCSC Golden Path with GeneCards custom track

Promoters for DDX19A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX19A on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX19A Gene

Chromosome:
16
Start:
70,346,829 bp from pter
End:
70,373,383 bp from pter
Size:
26,555 bases
Orientation:
Plus strand

Genomic View for DDX19A Gene

Genes around DDX19A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX19A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX19A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX19A Gene

Proteins for DDX19A Gene

  • Protein details for DDX19A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUU7-DD19A_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX19A
    Protein Accession:
    Q9NUU7
    Secondary Accessions:
    • B2RPL0
    • B4DRZ7
    • Q53FM0

    Protein attributes for DDX19A Gene

    Size:
    478 amino acids
    Molecular mass:
    53975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX19A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX19A Gene

Proteomics data for DDX19A Gene at MOPED

Post-translational modifications for DDX19A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX19A Gene

Gene Families for DDX19A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUU7

UniProtKB/Swiss-Prot:

DD19A_HUMAN :
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
Domain:
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
genes like me logo Genes that share domains with DDX19A: view

Function for DDX19A Gene

Molecular function for DDX19A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).

Enzyme Numbers (IUBMB) for DDX19A Gene

Gene Ontology (GO) - Molecular Function for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX19A: view
genes like me logo Genes that share phenotypes with DDX19A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX19A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX19A Gene

Localization for DDX19A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX19A Gene

Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX19A Gene COMPARTMENTS Subcellular localization image for DDX19A gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DDX19A Gene

Pathways & Interactions for DDX19A Gene

SuperPathways for DDX19A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DDX19A: view

No data available for Pathways by source and SIGNOR curated interactions for DDX19A Gene

Drugs & Compounds for DDX19A Gene

(1) Drugs for DDX19A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX19A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX19A: view

Transcripts for DDX19A Gene

Unigene Clusters for DDX19A Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX19A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - - - - -
SP7:
SP8:

Relevant External Links for DDX19A Gene

GeneLoc Exon Structure for
DDX19A
ECgene alternative splicing isoforms for
DDX19A

Expression for DDX19A Gene

mRNA expression in normal human tissues for DDX19A Gene

Protein differential expression in normal tissues from HIPED for DDX19A Gene

This gene is overexpressed in Lymph node (16.7) and Peripheral blood mononuclear cells (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX19A Gene



SOURCE GeneReport for Unigene cluster for DDX19A Gene Hs.656037

genes like me logo Genes that share expression patterns with DDX19A: view

Protein tissue co-expression partners for DDX19A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX19A Gene

Orthologs for DDX19A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX19A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX19A 35
  • 92.4 (n)
  • 97.07 (a)
DDX19A 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX19A 35
  • 93.17 (n)
  • 97.07 (a)
-- 36
  • 84 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ddx19a 35
  • 90.93 (n)
  • 97.49 (a)
Ddx19a 16
Ddx19a 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX19A 35
  • 99.37 (n)
  • 100 (a)
DDX19A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx19a 35
  • 91 (n)
  • 97.07 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX19B 36
  • 92 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:193690 35
  • 76.4 (n)
  • 83.58 (a)
ddx19 36
  • 84 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Dbp80 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ddx-19 35
  • 56.7 (n)
  • 54.31 (a)
ddx-19 36
  • 23 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR078W 35
  • 57.72 (n)
  • 52.71 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15950g 35
  • 53.85 (n)
  • 48.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP5 35
  • 54.14 (n)
  • 52.09 (a)
DBP5 36
  • 44 (a)
OneToMany
DBP5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons LOS4 35
  • 49.69 (n)
  • 40.68 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01160 35
  • 52.04 (n)
  • 46.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.06 35
  • 54.71 (n)
  • 55.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8406 36
  • 59 (a)
OneToMany
Species with no ortholog for DDX19A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DDX19A Gene

ENSEMBL:
Gene Tree for DDX19A (if available)
TreeFam:
Gene Tree for DDX19A (if available)

Paralogs for DDX19A Gene

Paralogs for DDX19A Gene

genes like me logo Genes that share paralogs with DDX19A: view

Variants for DDX19A Gene

Sequence variations from dbSNP and Humsavar for DDX19A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8063690 -- 70,367,784(+) aggca(A/T)cagaa intron-variant
rs775207 -- 70,366,029(-) CTGGA(A/G)ATCAA intron-variant
rs61741988 -- 70,366,100(+) CCAGA(A/T)GATCA reference, missense
rs16970121 -- 70,349,610(+) TCAGG(A/G)GAAGG intron-variant
rs16970133 -- 70,373,634(+) CTTTC(C/T)GCGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DDX19A Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
esv2714670 CNV Deletion 23290073
nsv833272 CNV Loss 17160897

Variation tolerance for DDX19A Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDX19A Gene

Disorders for DDX19A Gene

Relevant External Links for DDX19A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX19A

No disorders were found for DDX19A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX19A Gene

Publications for DDX19A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for DDX19A Gene

Sources for DDX19A Gene

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