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DDX19A Gene

protein-coding GIFtS: 50
GCID: GC16P070380

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A

(Previous name: DEAD (Asp-Glu-Ala-As) box polypeptide 19-like)
(Previous symbol: DDX19L)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A¹ ²		ATP-Dependent RNA Helicase DDX19A²
DDX19L¹ ² ³		DEAD (Asp-Glu-Ala-As) Box Polypeptide 19A²
DDX19-Like Protein² ³		RNA Helicase²
DEAD Box Protein 19A² ³		EC 3.6.4.13³
DEAD (Asp-Glu-Ala-As) Box Polypeptide 19-Like¹		EC 3.6.1⁸
DDX19-DDX19L²

External Ids:	HGNC: 25628¹	Entrez Gene: 55308²	Ensembl: ENSG00000168872⁷	UniProtKB: Q9NUU7³

Export aliases for DDX19A gene to outside databases

Previous GC identifers: GC16P068940 GC16P056213

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DDX19A Gene:

DDX19A (DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A) is a protein-coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX25.

UniProtKB/Swiss-Prot: DD19A_HUMAN, Q9NUU7

Function: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes,

DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are

dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000016.9 NT_010498.16 NC_018927.2

Regulatory elements:

Regulatory transcription factor binding sites in the DDX19A gene promoter:
C/EBPbeta ATF-2 Meis-1b c-Ets-1 Max FOXO4 SEF-1 (1) Meis-1a Meis-1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDX19A promoter sequence

Search Chromatin IP Primers for DDX19A

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX19A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

DDX19A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX19A gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P070380: view genomic region (about GC identifiers)

Start:	70,380,732 bp from pter	End:	70,407,286 bp from pter
Size:	26,555 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DD19A_HUMAN, Q9NUU7 (See protein sequence)

Recommended Name: ATP-dependent RNA helicase DDX19A

Size: 478 amino acids; 53975 Da

Secondary accessions: B2RPL0 Q53FM0

Explore the universe of human proteins at neXtProt for DDX19A: NX_Q9NUU7

Explore proteomics data for DDX19A at MOPED

Post-translational modifications:

Ubiquitination² at Lys63, Lys91, Lys186

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for DDX19A (Q9NUU7) (see all 16)

FVLDEAD

SPLYSVK

ALCNLYG

VINFDLP

See DDX19A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_060802.1

ENSEMBL proteins:

ENSP00000306117 ENSP00000457103 ENSP00000455134 ENSP00000455152 ENSP00000464207

ENSP00000456765 ENSP00000410243 ENSP00000460180 ENSP00000399208

DDX19A Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for DDX19A
	Novus Biologicals DDX19A Protein Novus Biologicals DDX19A Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for DDX19A
	Search eBioscience for Proteins for DDX19A
	antibodies-online proteins for DDX19A (4 products)
	antibodies-online peptides for DDX19A

DDX19A Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Abcam antibodies for DDX19A
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	ThermoFisher Antibodies for DDX19A
	antibodies-online antibodies for DDX19A (10 products)

DDX19A Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for DDX19A
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for DDX19A Cloud-Clone Corp. CLIAs for DDX19A
	Search eBioscience for ELISAs for DDX19A
	antibodies-online kits for DDX19A (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

DDX: DEAD-boxes

5 InterPro protein domains:

IPR011545 DNA/RNA_helicase_DEAD/DEAH_N

IPR027417 P-loop_NTPase

IPR014014 RNA_helicase_DEAD_Q_motif

IPR014001 Helicase_ATP-bd

IPR001650 Helicase_C

Graphical View of Domain Structure for InterPro Entry Q9NUU7

ProtoNet protein and cluster: Q9NUU7

UniProtKB/Swiss-Prot: DD19A_HUMAN, Q9NUU7

Domain: The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the

N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into

position for catalysis (By similarity)

Similarity: Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

Find genes that share domains with DDX19A About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: DD19A_HUMAN, Q9NUU7

Function: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes,

DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are

dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity)

Catalytic activity: ATP + H(2)O = ADP + phosphate

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.13¹

Gene Ontology (GO): Selected molecular function terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003676	nucleic acid binding	--	--
GO:0003723	RNA binding	IEA	--
GO:0004386	helicase activity	--	--
GO:0005524	ATP binding	IEA	--

Find genes that share ontologies with DDX19A About GenesLikeMe

Phenotypes:
3 GenomeRNAi human phenotypes for DDX19A:

G0/1 arrest

Increased G1 DNA content

Increased gamma-H2AX phosphory

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for DDX19A

miRNA Products:		miRTarBase miRNAs that target DDX19A: hsa-mir-31-5p (MIRT049879), hsa-mir-615-3p (MIRT039828), hsa-mir-124-3p (MIRT022423)

		Block miRNA regulation of human, mouse, rat DDX19A using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate DDX19A (see all 19):
		hsa-miR-579 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-507 hsa-let-7g hsa-let-7a hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: DDX19A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DDX19A
		Predesigned siRNA for gene silencing in human, mouse, rat DDX19A

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DDX19A

Clone Products:		OriGene clones in human, mouse for DDX19A (see all 7) OriGene ORF clones in mouse, rat for DDX19A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DDX19A (NM_018332)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX19A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX19A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DDX19A
		Browse ESI BIO Cell Lines and PureStem Progenitors for DDX19A

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX19A

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

DD19A_HUMAN, Q9NUU7: Cytoplasm (By similarity). Nucleus, nuclear pore complex. Nucleus membrane; Peripheral

membrane protein; Cytoplasmic side (By similarity). Note=Nuclear pore complex cytoplasmic fibrils

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytosol	2
peroxisome	1

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005643	nuclear pore	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0031965	nuclear membrane	IEA	--

Find genes that share ontologies with DDX19A About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for DDX19A
Interactions:

Search GeneGlobe Interaction Network for DDX19A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DDX19A (Q9NUU7^{2, 3} ENSP00000306117⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 916)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDX39B	Q13838²^,³, ENSP00000379475⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000379475
ENSG00000225073	Q13838²^,³, ENSP00000400326⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000400326
ENSG00000215425	Q13838²^,³	MINT-7945693 MINT-7947479 I2D: score=1
ENSG00000225859	Q13838²^,³	MINT-7945693 MINT-7947479 I2D: score=1
ENSG00000229496	Q13838²^,³	MINT-7945693 MINT-7947479 I2D: score=1

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--
GO:0010043	response to zinc ion	IEA	--
GO:0015031	protein transport	IEA	--
GO:0043065	positive regulation of apoptotic process	IEA	--
GO:0051028	mRNA transport	IEA	--

Find genes that share ontologies with DDX19A About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for DDX19A (DD19A)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DDX19A gene:

NM_018332.3

Unigene Cluster for DDX19A:

DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A

Hs.656037 [show with all ESTs]

Unigene Representative Sequence: AB209401

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000302243(uc010cfq.1 uc002eys.3 uc010cfs.3 uc010vlz.2 uc002eyv.3 uc010vma.2)

ENST00000562509 ENST00000565195 ENST00000569771(uc010cfr.3) ENST00000566167

ENST00000569244 ENST00000561574 ENST00000562649 ENST00000569319 ENST00000417604

ENST00000567012 ENST00000575878 ENST00000566574 ENST00000568779 ENST00000562140

ENST00000443119

miRNA Products:		Block miRNA regulation of human, mouse, rat DDX19A using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate DDX19A (see all 19):
		hsa-miR-579 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-507 hsa-let-7g hsa-let-7a hsa-miR-7-1*

		SwitchGear 3'UTR luciferase reporter plasmid: DDX19A 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for DDX19A
		Predesigned siRNA for gene silencing in human, mouse, rat DDX19A

Clone Products:		OriGene clones in human, mouse for DDX19A (see all 7) OriGene ORF clones in mouse, rat for DDX19A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DDX19A (NM_018332)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX19A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX19A

Primer Products:		OriGene qPCR primer pairs and template standards for DDX19A OriGene qSTAR qPCR primer pairs in human, mouse for DDX19A
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DDX19A
		QuantiTect SYBR Green Assays in human, mouse, rat DDX19A
		QuantiFast Probe-based Assays in human, mouse, rat DDX19A

Additional mRNA sequence:

AB209401.1 AK001988.1 AK125701.1 AK223262.1 AK299504.1 AK299539.1 AK310604.1 AK310804.1

AK310808.1 AL832901.1 AL832970.1 BC005162.2 BC006544.2 BC137496.1 BC137497.1 CR749227.1

23 DOTS entries:

DT.453128 DT.95266032 DT.120659616 DT.120659682 DT.120659668 DT.70105447 DT.92467020 DT.95230620

DT.120659659 DT.95266035 DT.100795833 DT.120659661 DT.120659664 DT.75138910 DT.75153768 DT.91847880

DT.95105861 DT.100712757 DT.100795830 DT.101959511 DT.120659573 DT.120659649 DT.438352

Selected AceView cDNA sequences (see all 474):

CR625899 AI382892 BQ887457 AI612876 BM988409 BQ939975 BE019902 BQ650066

BG392444 BM918229 CA447721 BQ883412 AI818499 CR594442 BQ680080 BQ680805

BC003626 BC025771 AI689353 CB129213 CD367602 AI273565 BM683133 BQ940784

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDX19A (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10
SP1:											-		-						-				-		-		-
SP2:											-		-						-				-		-		-
SP3:																			-				-		-		-
SP4:											-		-
SP5:											-		-						-

ECgene alternative splicing isoforms for DDX19A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DDX19A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

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DDX19A Protein expression data from MOPED¹, PaxDb² and MaxQB³:

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DDX19A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.656037

Custom PCR Arrays for DDX19A

Primer Products:		OriGene qPCR primer pairs and template standards for DDX19A OriGene qSTAR qPCR primer pairs in human, mouse for DDX19A
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat DDX19A
		QuantiTect SYBR Green Assays in human, mouse, rat DDX19A
		QuantiFast Probe-based Assays in human, mouse, rat DDX19A

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX19A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX19A gene from Selected species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ddx19a^{1 , 5}	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19a^{1, 5}	90.93(n)¹ 97.49(a)¹		8 (57.86 cM)⁵ 13680¹ NM_007916.2¹ NP_031942.2¹ 110974996⁵
chicken (Gallus gallus)	Aves	DDX19B⁶	Gallus gallus DEAD (Asp-Glu-Ala-Asp) box polypepti...	92(a)	1 → many	21(4849821-4857034)
zebrafish (Danio rerio)	Actinopterygii	zgc:193690¹	zgc:193690	76.4(n) 83.58(a)		563448 NM_001128715.1 NP_001122187.1
fruit fly (Drosophila melanogaster)	Insecta	Dbp80⁶	Dead box protein 80	52(a)	1 → many	3LHet(2409852-2545146)
worm (Caenorhabditis elegans)	Secernentea	ddx-19¹	ddx-19	56.7(n) 54.31(a)		174418 NM_001267257.1 NP_001254186.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	DBP5(YOR046C)⁴ DBP5¹	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p less⁴ DBP5¹	54.14(n)¹ 52.09(a)¹		15(415907-414459)⁴ 854211^{1, 4} NP_014689.1^{1, 4}
thale cress (Arabidopsis thaliana)	eudicotyledons	LOS4¹	LOS4	49.69(n) 40.68(a)		824477 NM_115171.3 NP_190879.1

ENSEMBL Gene Tree for DDX19A (if available)
TreeFam Gene Tree for DDX19A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for DDX19A gene

DDX25² ENSG00000260537² DDX19B²

Selected SIMAP similar genes for DDX19A using alignment to 9 protein entries: DD19A_HUMAN (see all proteins) (see all similar genes):

DKFZp686C21137 DKFZp762C1313 DDX19L DDX19B DDX25 ETFA

SYNE1 DDX56 ADCY7 L3MBTL2 PAM16 BAT1

EIF4A3 EIF4A2 DKFZp547B159 MST162 EIF4A1 DDX6

Find genes that share paralogs with DDX19A About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189715232^1,2		--	70382678(+)	`TTTCTA/GCAAAA`	1	--	int¹		0	--	--	--	--
rs113405048^1,2	F	--	70382704(+)	`GCTGGG/ACGGGG`	1	--	int¹		1		CSA	2
rs138374877^1,2		--	70382706(+)	`TGGGCA/GGGGTG`	1	--	int¹		0	--	--	--	--
rs184272136^1,2	C	--	70382716(+)	`GGTGGC/TACACT`	1	--	int¹		0	--	--	--	--
rs188470328^1,2		--	70382889(+)	`CTGTTC/GTGAAT`	1	--	int¹		0	--	--	--	--
rs149252839^1,2	C	--	70382960(+)	`TTGACA/GATTTG`	1	--	int¹		0	--	--	--	--
rs181899924^1,2		--	70383036(+)	`TACAAA/GGCAAA`	1	--	int¹		0	--	--	--	--
rs186548813^1,2		--	70383099(+)	`TTCCAA/GGTTAT`	1	--	int¹		0	--	--	--	--
rs190554579^1,2		--	70383109(+)	`TCTCCC/TAATGG`	1	--	int¹		0	--	--	--	--
rs7200034^1,2	C,F,A,H	--	70383112(+)	`cccaaT/Cggagt`	1	--	int¹		18		NS EA NA WA	1914

HapMap Linkage Disequilibrium report for DDX19A (70380732 - 70407286 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for DDX19A: About this table

Variant ID	Type	Subtype	PubMed ID
esv2714670	CNV	Deletion	23290073
nsv833272	CNV	Loss	17160897
nsv7285	OTHER	Inversion	18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DDX19A gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with DDX19A)

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)¹ Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (Sci Signal 2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)² Bienvenut W.V....Giglione C. (amp 2012)
A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (Nat. Methods 2012)
Maintenance of silent chromatin through replication requires SWI/SNF- like chromatin remodeler SMARCAD1. (PubMed id 21549307)¹ Rowbotham S.P.... Mermoud J.E. (Mol. Cell 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55308	HGNC: 25628	AceView: DDX19andFLJ11126	Ensembl:ENSG00000168872	euGenes: HUgn55308
ECgene: DDX19A	H-InvDB: DDX19A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DDX19A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DDX19A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DDX19A gene:
Search GeneIP for patents involving DDX19A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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DDX19A Gene

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A

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DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A

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