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Aliases for DDX19A Gene

Aliases for DDX19A Gene

  • DEAD-Box Helicase 19A 2 3 5
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A 2 3
  • DEAD Box Protein 19A 3 4
  • DDX19-Like Protein 3 4
  • DDX19L 3 4
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19-Like 2
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19A 3
  • ATP-Dependent RNA Helicase DDX19A 3
  • RNA Helicase 3
  • DDX19-DDX19L 3
  • EC 3.6.4.13 4
  • EC 3.6.1 58

External Ids for DDX19A Gene

Previous HGNC Symbols for DDX19A Gene

  • DDX19L

Previous GeneCards Identifiers for DDX19A Gene

  • GC16P068940
  • GC16P070380
  • GC16P056213
  • GC16P070299

Summaries for DDX19A Gene

GeneCards Summary for DDX19A Gene

DDX19A (DEAD-Box Helicase 19A) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is ENSG00000260537.

UniProtKB/Swiss-Prot for DDX19A Gene

  • ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).

Additional gene information for DDX19A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX19A Gene

Genomics for DDX19A Gene

Regulatory Elements for DDX19A Gene

Enhancers for DDX19A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H069402 2 FANTOM5 Ensembl ENCODE dbSUPER 55.1 -938.7 -938652 11 PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF302 FOS NFAT5 PDPR DDX19A LOC400541 PDXDC2P-NPIPB14P NONOP1 PDXDC2P NPIPB14P SNTB2 UTP4
GH16H070986 1.3 Ensembl ENCODE 44.7 +640.6 640633 1 PKNOX1 ZNF133 GLI4 ZNF2 FOS SP3 YY2 REST TSHZ1 ZNF518A SF3B3 PDPR PDXDC2P-NPIPB14P DDX19A LOC400541 EXOSC6 HYDIN DDX19B NPIPB14P PDXDC2P
GH16H070287 1.4 ENCODE dbSUPER 37.1 -57.4 -57371 4 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 FOS PDPR DDX19A DDX19B SMG1P7 LOC400541 NFAT5 SF3B3 NONOP1 PDXDC2P-NPIPB14P COG4
GH16H070779 1.3 ENCODE dbSUPER 22.7 +432.4 432446 1 PKNOX1 ATF1 ARID4B SIN3A FEZF1 ZNF2 ZNF121 ZNF302 FOS DEK PDPR LOC400541 ZNF23 DDX19A ENSG00000247324 ZNF19 LOC100506083 DDX19B VAC14 AARS
GH16H069721 1.7 FANTOM5 ENCODE dbSUPER 14.2 -621.6 -621578 7 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 SLC30A9 ZNF766 SF3B3 SNTB2 NONOP1 CHTF8 NFAT5 DDX19B PDPR NPIPB14P PDXDC2P-NPIPB14P NIP7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX19A on UCSC Golden Path with GeneCards custom track

Promoters for DDX19A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087554 271 1801 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3

Genomic Location for DDX19A Gene

Chromosome:
16
Start:
70,346,829 bp from pter
End:
70,373,383 bp from pter
Size:
26,555 bases
Orientation:
Plus strand

Genomic View for DDX19A Gene

Genes around DDX19A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX19A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX19A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX19A Gene

Proteins for DDX19A Gene

  • Protein details for DDX19A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUU7-DD19A_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX19A
    Protein Accession:
    Q9NUU7
    Secondary Accessions:
    • B2RPL0
    • B4DRZ7
    • Q53FM0

    Protein attributes for DDX19A Gene

    Size:
    478 amino acids
    Molecular mass:
    53975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX19A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX19A Gene

Selected DME Specific Peptides for DDX19A Gene

Q9NUU7:
  • IGTPGTVLDWC
  • VINFDLP
  • FVLDEAD
  • SVKSFEEL
  • HRIGRTGR
  • ALCNLYG
  • GTGKTAAF
  • EEEKEDRAAQSLLNKLIRSNLVDNTNQVEVLQRDP
  • YLHRIGR
  • SPLYSVK
  • YAMGFNRPSKIQE
  • GHQVALLSGE
  • ALPMMLA
  • CQMLLFSATFEDSVW
  • TTNVCARGIDV
  • PDPNVIKL

Post-translational modifications for DDX19A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX19A Gene

Gene Families for DDX19A Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

Q9NUU7

UniProtKB/Swiss-Prot:

DD19A_HUMAN :
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
Domain:
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
Family:
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
genes like me logo Genes that share domains with DDX19A: view

Function for DDX19A Gene

Molecular function for DDX19A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).

Enzyme Numbers (IUBMB) for DDX19A Gene

Gene Ontology (GO) - Molecular Function for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
genes like me logo Genes that share ontologies with DDX19A: view
genes like me logo Genes that share phenotypes with DDX19A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DDX19A

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DDX19A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX19A Gene

Localization for DDX19A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX19A Gene

Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX19A gene
Compartment Confidence
nucleus 4
cytosol 4
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore IEA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with DDX19A: view

Pathways & Interactions for DDX19A Gene

SuperPathways for DDX19A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
GO:0008380 RNA splicing IBA --
GO:0010468 regulation of gene expression IBA --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX19A: view

No data available for Pathways by source and SIGNOR curated interactions for DDX19A Gene

Drugs & Compounds for DDX19A Gene

(3) Drugs for DDX19A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for DDX19A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX19A: view

Transcripts for DDX19A Gene

Unigene Clusters for DDX19A Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DDX19A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DDX19A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - - - - -
SP7:
SP8:

Relevant External Links for DDX19A Gene

GeneLoc Exon Structure for
DDX19A
ECgene alternative splicing isoforms for
DDX19A

Expression for DDX19A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX19A Gene

Protein differential expression in normal tissues from HIPED for DDX19A Gene

This gene is overexpressed in Lymph node (16.7) and Peripheral blood mononuclear cells (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX19A Gene



Protein tissue co-expression partners for DDX19A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX19A Gene:

DDX19A

SOURCE GeneReport for Unigene cluster for DDX19A Gene:

Hs.656037

Evidence on tissue expression from TISSUES for DDX19A Gene

  • Nervous system(4.8)
  • Muscle(4.2)
  • Stomach(4.2)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with DDX19A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX19A Gene

Orthologs for DDX19A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX19A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX19A 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 97 (a)
OneToMany
DDX19A 33
  • 93.17 (n)
-- 34
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DDX19A 33 34
  • 92.4 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ddx19a 33
  • 91 (n)
mouse
(Mus musculus)
Mammalia Ddx19a 33 16 34
  • 90.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDX19B 34
  • 92 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ddx19 34
  • 84 (a)
OneToMany
zgc:193690 33
  • 76.4 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dbp80 34
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ddx-19 33 34
  • 56.7 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR078W 33
  • 57.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP5 33 34 36
  • 54.14 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15950g 33
  • 53.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons LOS4 33
  • 49.69 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8406 34
  • 59 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.06 33
  • 54.71 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01160 33
  • 52.04 (n)
Species where no ortholog for DDX19A was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DDX19A Gene

ENSEMBL:
Gene Tree for DDX19A (if available)
TreeFam:
Gene Tree for DDX19A (if available)

Paralogs for DDX19A Gene

Variants for DDX19A Gene

Sequence variations from dbSNP and Humsavar for DDX19A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000039979 -- 70,373,493(+) AACCC(A/G)TTTTT downstream-variant-500B
rs1000048210 -- 70,354,314(+) GCTAA(-/T)TTTGT intron-variant
rs1000084279 -- 70,360,496(+) TTCTT(-/TTTTGTTTTG)TTTTG intron-variant
rs1000118741 -- 70,368,009(+) CATTT(C/T)TAAAA intron-variant
rs1000209904 -- 70,366,423(+) CAGTC(A/C)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX19A Gene

Variant ID Type Subtype PubMed ID
esv2714670 CNV deletion 23290073
esv3638953 CNV loss 21293372
nsv7285 OTHER inversion 18451855
nsv833272 CNV loss 17160897
nsv977995 CNV duplication 23825009

Variation tolerance for DDX19A Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX19A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX19A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX19A Gene

Disorders for DDX19A Gene

Relevant External Links for DDX19A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX19A

No disorders were found for DDX19A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX19A Gene

Publications for DDX19A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for DDX19A Gene

Sources for DDX19A Gene

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