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Aliases for DDX19A Gene

Aliases for DDX19A Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A 2 3
  • DEAD Box Protein 19A 3 4
  • DDX19-Like Protein 3 4
  • DDX19L 3 4
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19-Like 2
  • DEAD (Asp-Glu-Ala-As) Box Polypeptide 19A 3
  • ATP-Dependent RNA Helicase DDX19A 3
  • RNA Helicase 3
  • DDX19-DDX19L 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DDX19A Gene

Previous HGNC Symbols for DDX19A Gene

  • DDX19L

Previous GeneCards Identifiers for DDX19A Gene

  • GC16P068940
  • GC16P070380
  • GC16P056213

Summaries for DDX19A Gene

GeneCards Summary for DDX19A Gene

DDX19A (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 19A) is a Protein Coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is ENSG00000260537.

UniProtKB/Swiss-Prot for DDX19A Gene

  • ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX19A Gene

Genomics for DDX19A Gene

Regulatory Elements for DDX19A Gene

Genomic Location for DDX19A Gene

Start:
70,299,224 bp from pter
End:
70,373,383 bp from pter
Size:
74,160 bases
Orientation:
Plus strand

Genomic View for DDX19A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX19A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX19A Gene

Proteins for DDX19A Gene

  • Protein details for DDX19A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUU7-DD19A_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX19A
    Protein Accession:
    Q9NUU7
    Secondary Accessions:
    • B2RPL0
    • B4DRZ7
    • Q53FM0

    Protein attributes for DDX19A Gene

    Size:
    478 amino acids
    Molecular mass:
    53975 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDX19A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX19A Gene

Proteomics data for DDX19A Gene at MOPED

Post-translational modifications for DDX19A Gene

  • Ubiquitination at Lys63, Lys91, and Lys186
  • Modification sites at PhosphoSitePlus

Domains for DDX19A Gene

Gene Families for DDX19A Gene

HGNC:
  • DDX :DEAD-boxes

Suggested Antigen Peptide Sequences for DDX19A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NUU7

UniProtKB/Swiss-Prot:

DD19A_HUMAN :
  • Q9NUU7
Domain:
  • The N-terminal extension helix acts as an autoinhibitory domain, preventing ATP hydrolysis, unless the N-terminus of the protein is displaced by RNA binding, allowing cleft closure to bring key side chains into position for catalysis.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.
genes like me logo Genes that share domains with DDX19A: view

Function for DDX19A Gene

Molecular function for DDX19A Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity).

Enzyme Numbers (IUBMB) for DDX19A Gene

Gene Ontology (GO) - Molecular Function for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity --
genes like me logo Genes that share ontologies with DDX19A: view

Phenotypes for DDX19A Gene

genes like me logo Genes that share phenotypes with DDX19A: view

miRNA for DDX19A Gene

miRTarBase miRNAs that target DDX19A

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX19A Gene

Localization for DDX19A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX19A Gene

Cytoplasm. Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Nuclear pore complex cytoplasmic fibrils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX19A Gene COMPARTMENTS Subcellular localization image for DDX19A gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005643 nuclear pore IEA --
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with DDX19A: view

Pathways for DDX19A Gene

SuperPathways for DDX19A Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX19A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006406 mRNA export from nucleus IBA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process --
GO:0010043 response to zinc ion IEA --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX19A: view

No data available for Pathways by source for DDX19A Gene

Transcripts for DDX19A Gene

Unigene Clusters for DDX19A Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX19A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - - - - -
SP7:
SP8:

Relevant External Links for DDX19A Gene

GeneLoc Exon Structure for
DDX19A
ECgene alternative splicing isoforms for
DDX19A

Expression for DDX19A Gene

mRNA expression in normal human tissues for DDX19A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX19A Gene

SOURCE GeneReport for Unigene cluster for DDX19A Gene Hs.656037

genes like me logo Genes that share expressions with DDX19A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX19A Gene

Orthologs for DDX19A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX19A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX19A 35
  • 99.37 (n)
  • 100 (a)
DDX19A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX19A 35
  • 92.4 (n)
  • 97.07 (a)
DDX19A 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
DDX19A 35
  • 93.17 (n)
  • 97.07 (a)
mouse
(Mus musculus)
Mammalia Ddx19a 35
  • 90.93 (n)
  • 97.49 (a)
Ddx19a 16
Ddx19a 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 92 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ddx19a 35
  • 91 (n)
  • 97.07 (a)
chicken
(Gallus gallus)
Aves DDX19B 36
  • 92 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ddx19 36
  • 84 (a)
OneToMany
zgc:193690 35
  • 76.4 (n)
  • 83.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dbp80 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ddx-19 35
  • 56.7 (n)
  • 54.31 (a)
ddx-19 36
  • 23 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR078W 35
  • 57.72 (n)
  • 52.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP5 35
  • 54.14 (n)
  • 52.09 (a)
DBP5 36
  • 44 (a)
OneToMany
DBP5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15950g 35
  • 53.85 (n)
  • 48.89 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons LOS4 35
  • 49.69 (n)
  • 40.68 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01160 35
  • 52.04 (n)
  • 46.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC12C2.06 35
  • 54.71 (n)
  • 55.04 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8406 36
  • 59 (a)
OneToMany
Species with no ortholog for DDX19A:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DDX19A Gene

ENSEMBL:
Gene Tree for DDX19A (if available)
TreeFam:
Gene Tree for DDX19A (if available)

Paralogs for DDX19A Gene

Paralogs for DDX19A Gene

genes like me logo Genes that share paralogs with DDX19A: view

Variants for DDX19A Gene

Sequence variations from dbSNP and Humsavar for DDX19A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs775207 -- 70,366,029(-) CTGGA(A/G)ATCAA intron-variant
rs1055783 -- 70,361,466(+) CGACC(A/C/T)TCCAA synonymous-codon, reference
rs1058430 -- 70,372,046(+) AGTGC(A/G)TTTAG utr-variant-3-prime
rs1058432 -- 70,372,049(+) GCATT(C/T)AGGGC utr-variant-3-prime
rs1065159 -- 70,364,576(+) TCTGG(C/T)ACTGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DDX19A Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
esv2714670 CNV Deletion 23290073
nsv833272 CNV Loss 17160897

Relevant External Links for DDX19A Gene

HapMap Linkage Disequilibrium report
DDX19A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX19A Gene

Disorders for DDX19A Gene

No disorders were found for DDX19A Gene.

No data available for UniProtKB/Swiss-Prot for DDX19A Gene

Publications for DDX19A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for DDX19A Gene

Sources for DDX19A Gene

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