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DDX18 Gene

protein-coding   GIFtS: 59
GCID: GC02P118572

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 18

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 18 (Myc-regulated))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 181 2     Myc-Regulated DEAD Box Protein2 3
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 18 (Myc-Regulated)1 2     ATP-Dependent RNA Helicase DDX182
MrDb2 3     EC 3.6.4.133
DEAD Box Protein 182 3     EC 3.6.18

External Ids:    HGNC: 27411   Entrez Gene: 88862   Ensembl: ENSG000000882057   OMIM: 6063555   UniProtKB: Q9NVP13   

Export aliases for DDX18 gene to outside databases

Previous GC identifers: GC02P115777 GC02P116493 GC02P118479 GC02P118667 GC02P118288 GC02P110899


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX18 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein.
(provided by RefSeq, Jul 2008)

GeneCards Summary for DDX18 Gene:
DDX18 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 18) is a protein-coding gene. Diseases associated with DDX18 include breast and colorectal cancer, and neuroblastoma. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot: DDX18_HUMAN, Q9NVP1
Function: Probable RNA-dependent helicase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DDX18 gene promoter:
         c-Fos   Egr-1   Pax-2   Pax-2a   AREB6   PPAR-gamma1   Pax-2b   COMP1   Chx10   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDX18 promoter sequence
   Search Chromatin IP Primers for DDX18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.1   Ensembl cytogenetic band:  2q14.1   HGNC cytogenetic band: 2q21.2

DDX18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX18 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P118572:  view genomic region     (about GC identifiers)

Start:
118,572,226 bp from pter      End:
118,589,955 bp from pter
Size:
17,730 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX18_HUMAN, Q9NVP1 (See protein sequence)
Recommended Name: ATP-dependent RNA helicase DDX18  
Size: 670 amino acids; 75407 Da
Subunit: Interacts with NOL8; the interaction is RNA-dependent
Sequence caution: Sequence=CAA67295.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for DDX18:
3LY5 (3D)    
Secondary accessions: Q6GTZ9 Q6IAU4 Q92732 Q9BQB7

Explore the universe of human proteins at neXtProt for DDX18: NX_Q9NVP1

Explore proteomics data for DDX18 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys195, Lys571
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX18 (Q9NVP1) (see all 24)
     RVGRTAR  FLIPAVE  KRTTTFF  LVIDEAD 


    See DDX18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006764.3  
    ENSEMBL proteins: 
     ENSP00000263239   ENSP00000415604  

    DDX18 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for DDX18
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DDX18
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    Novus Biologicals DDX18 Protein
    Novus Biologicals DDX18 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX18

    DDX18 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for DDX18

    DDX18 Assay Products:

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    Cloud-Clone Corp. ELISAs for DDX18
    Cloud-Clone Corp. CLIAs for DDX18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR025313 DUF4217
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif

    Graphical View of Domain Structure for InterPro Entry Q9NVP1

    ProtoNet protein and cluster: Q9NVP1

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX18_HUMAN, Q9NVP1
    Similarity: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX18_HUMAN, Q9NVP1
    Function: Probable RNA-dependent helicase
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0004004ATP-dependent RNA helicase activity TAS8861962
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI16963496
         
    DDX18 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DDX18:
     Decreased viability of wild-ty  Increased S DNA content  Increased gamma-H2AX phosphory  Nucleolar pre-40S maturation d 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDX18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDX18

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDX18:
    hsa-mir-99a-5p (MIRT048605), hsa-mir-128-3p (MIRT045851), hsa-let-7b-5p (MIRT052091), hsa-let-7a-5p (MIRT052470), hsa-let-7c-5p (MIRT051780), hsa-mir-324-3p (MIRT042964)

    Block miRNA regulation of human, mouse, rat DDX18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX18 (see all 13):
    hsa-miR-3673 hsa-miR-18a hsa-miR-425 hsa-miR-551b* hsa-miR-211 hsa-miR-103a hsa-miR-409-5p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidDDX18 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDX18
    Predesigned siRNA for gene silencing in human, mouse, rat DDX18

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDX18

    Clone
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    OriGene clones in human, mouse for DDX18 (see all 7)
    OriGene ORF clones in mouse, rat for DDX18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX18 (NM_006773)
    Sino Biological Human cDNA Clone for DDX18
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX18

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DDX18
    Browse ESI BIO Cell Lines and PureStem Progenitors for DDX18 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX18_HUMAN, Q9NVP1: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--

    DDX18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDX18 About    
    See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional activation
    Validated targets of C-MYC transcriptional activation


    1 BioSystems Pathway for DDX18
        Validated targets of C-MYC transcriptional activation



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX18
    Interactions:

        Search GeneGlobe Interaction Network for DDX18

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX18 (Q9NVP12, 3 ENSP000002632394) via UniProtKB, MINT, STRING, and/or I2D (see all 447)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process TAS8861962

    DDX18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX18

    1 Novoseek inferred chemical compound relationship for DDX18 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 26.1 1 10704843 (1)



    DDX18 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DDX18 gene: 
    NM_006773.3  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263239(uc002tlh.1) ENST00000474694 ENST00000489933 ENST00000415038
    ENST00000476149 ENST00000461443
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDX18 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX18 (see all 13):
    hsa-miR-3673 hsa-miR-18a hsa-miR-425 hsa-miR-551b* hsa-miR-211 hsa-miR-103a hsa-miR-409-5p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidDDX18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDX18
    Predesigned siRNA for gene silencing in human, mouse, rat DDX18
    Clone
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    OriGene clones in human, mouse for DDX18 (see all 7)
    OriGene ORF clones in mouse, rat for DDX18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDX18 (NM_006773)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX18
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDX18
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX18
      QuantiTect SYBR Green Assays in human, mouse, rat DDX18
      QuantiFast Probe-based Assays in human, mouse, rat DDX18

    Selected AceView cDNA sequences (see all 427):

    BM461491 BM697929 CB117405 BI094337 BM680844 CB130687 BX446830 AU132034 
    BM451096 BM702843 BQ084064 BU674531 NM_006773 AL120880 CB134802 BC024739 
    AW183624 BQ424822 BE396914 AI472521 BQ708725 AU124767 BX504280 BQ004497 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DDX18    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                                            
    SP2:                                      -                                                                     
    SP3:                                                                    -                                       
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for DDX18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTTTCCT
    DDX18 Expression
    About this image

    DDX18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX18 Protein Expression
        Custom PCR Arrays for DDX18
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DDX18
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX18 gene from Selected species (see all 28)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx181 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 181, 5 83.56(n)1
    87.71(a)1
      1 (52.98 cM)5
    669421  NM_025860.31  NP_080136.21 
     1215538355 
    chicken
    (Gallus gallus)
    Aves DDX181 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 73.67(n)
    79.94(a)
      424278  XM_422125.4  XP_422125.3 
    lizard
    (Anolis carolinensis)
    Reptilia DDX186
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
    76(a)
    1 ↔ 1
    1(82159582-82177456)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238012 Xenopus laevis transcribed sequence with moderate similarity more 78.59(n)    BQ725520.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb1552 sbcb155 76.57(n)   321127  CD758434.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pit1 , 3 ATP dependent RNA helicase3
    pitchoune1
    72(a)
    (best of 2)3
    67.99(n)1
    78.59(a)1
      93F143
    425951  NM_169991.21  NP_732694.21 
    worm
    (Caenorhabditis elegans)
    Secernentea B0511.61 , 3 helicase3
    B0511.61
    67(a)
    (best of 2)3
    61.57(n)1
    64.48(a)1
      I(10633448-10636276)3
    1729541  NM_060378.41  NP_492779.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HAS1(YMR290C)4
    HAS11
    ATP-dependent RNA helicase; localizes to both the nuclear more4
    HAS11
    61.63(n)1
    61.22(a)1
      13(851591-850074)4
    8553351, 4  NP_014017.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G186001 AT3G18600 59.68(n)
    58.27(a)
      821391  NM_112746.5  NP_188490.1 
    rice
    (Oryza sativa)
    Liliopsida Os.57992 Transcribed sequence with weak similarity to protein more 70.23(n)    AU225557.1 


    ENSEMBL Gene Tree for DDX18 (if available)
    TreeFam Gene Tree for DDX18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX18 gene
    16 SIMAP similar genes for DDX18 using alignment to 4 protein entries:     DDX18_HUMAN (see all proteins):
    DDX10    DDX54    EIF4A3    EIF4A2    DDX39B    DDX41
    E4-DBP    MST162    DDX55    DDX47    EIF4A1    DDX49
    DKFZp564G1016    DDX5    DDX31    mcdrh

    DDX18 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for DDX18 (see all 7)
    PGOHUM00000238886 PGOHUM00000242932 PGOHUM00000248216 PGOHUM00000246808 PGOHUM00000240407


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX18 (see all 479)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358414
    A breast cancer sample4--see VAR_0358412 G R mis40--------
    rs175671441,2
    C,F,H--118570273(+) TTTGAG/ATAGCT 1 -- us2k19Minor allele frequency- A:0.04NA NS EA 670
    rs1470002081,2
    --118570723(+) GTTGTA/GTCTAT 1 -- us2k10--------
    rs1390556471,2
    --118570767(+) ATCAGA/GTAAAT 1 -- us2k10--------
    rs1852634531,2
    --118570824(+) ATGCAC/TATATA 1 -- us2k10--------
    rs1885518321,2
    --118570888(+) GTTTGC/TGTGTG 1 -- us2k10--------
    rs1415162781,2
    --118570901(+) TGTGCA/GCTCTT 1 -- us2k10--------
    rs1118813961,2
    C--118570914(+) ATTTCT/CGAATC 1 -- us2k12Minor allele frequency- C:0.04CSA WA 120
    rs1138807731,2
    C,F--118570936(+) TGCCTG/TATCAT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1382379411,2
    C--118571009(+) GATTTC/TGAAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDX18 (118572226 - 118589955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDX18:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2889CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX18
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606355    OMIM disorders: --

    11 diseases for DDX18:    
    About MalaCards
    breast and colorectal cancer    neuroblastoma    rheumatoid arthritis    arthritis
    hiv-1    lung cancer    multiple myeloma    malaria
    myeloma    colorectal cancer    breast cancer


    DDX18 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DDX18 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 5 18351129 (4)

    Genetic Association Database (GAD): DDX18
    Human Genome Epidemiology (HuGE) Navigator: DDX18 (3 documents)

    Export disorders for DDX18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX18 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with DDX18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. (PubMed id 8861962)1, 2, 3 Grandori C.... Eisenman R.E. (EMBO J. 1996)
    2. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (PLoS ONE 2010)
    3. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PubMed id 16963496)1, 2 Sekiguchi T.... Nishimoto T. (Nucleic Acids Res. 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Cellular studies of MrDb (DDX18). (PubMed id 18351129)1, 9 Dubaele S. and ChA"ne P. (Oncol. Res. 2007)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8886 HGNC: 2741 AceView: DDX18 Ensembl:ENSG00000088205 euGenes: HUgn8886
    ECgene: DDX18 H-InvDB: DDX18

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX18 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDX18 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDX18 gene:
    Search GeneIP for patents involving DDX18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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