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Aliases for DDX18 Gene

Aliases for DDX18 Gene

  • DEAD-Box Helicase 18 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 18 (Myc-Regulated) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 18 2 3
  • Myc-Regulated DEAD Box Protein 3 4
  • DEAD Box Protein 18 3 4
  • MrDb 3 4
  • ATP-Dependent RNA Helicase DDX18 3
  • EC 3.6.4.13 4
  • EC 3.6.1 61
  • CPERP-D 4

External Ids for DDX18 Gene

Previous GeneCards Identifiers for DDX18 Gene

  • GC02P115777
  • GC02P116493
  • GC02P118479
  • GC02P118667
  • GC02P118288
  • GC02P118572
  • GC02P110899
  • GC02P117837
  • GC02P117843
  • GC02P117849
  • GC02P117851

Summaries for DDX18 Gene

Entrez Gene Summary for DDX18 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX18 Gene

DDX18 (DEAD-Box Helicase 18) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for DDX18 Gene

  • Probable RNA-dependent helicase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX18 Gene

Genomics for DDX18 Gene

Regulatory Elements for DDX18 Gene

Enhancers for DDX18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F117813 1.2 ENCODE 28.3 +0.6 556 3.5 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 DDX18 CCDC93 LOC102723413 HTR5BP GC02P117854
GH02F118084 1.5 FANTOM5 ENCODE 12.8 +273.2 273224 6.3 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 INSIG2 DDX18 CCDC93 HTR5BP RN7SL111P
GH02F117978 1.6 FANTOM5 Ensembl ENCODE 7.7 +166.1 166130 3.6 HDAC1 CBX3 TBL1XR1 RAD21 ZNF766 FOS CREM ZBTB11 NCOA1 CEBPB CCDC93 HTR5BP DDX18 GC02M117974 GC02M117973 LOC102723413
GH02F118121 1.2 Ensembl ENCODE 6.7 +309.0 309020 3.4 PKNOX1 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ZNF207 ZNF263 ZHX2 MIER2 INSIG2 DDX18 HTR5BP GC02M118122 GC02P118132
GH02F118059 1.1 Ensembl ENCODE 5.6 +246.0 245951 2.8 TBL1XR1 BMI1 ZNF48 RAD21 ETV6 CREM ZNF654 CBFB CEBPB JUNB CCDC93 INSIG2 DDX18 RN7SL111P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX18 on UCSC Golden Path with GeneCards custom track

Promoters for DDX18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000015441 350 1601 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for DDX18 Gene

Chromosome:
2
Start:
117,814,650 bp from pter
End:
117,832,379 bp from pter
Size:
17,730 bases
Orientation:
Plus strand

Genomic View for DDX18 Gene

Genes around DDX18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX18 Gene

Proteins for DDX18 Gene

  • Protein details for DDX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVP1-DDX18_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX18
    Protein Accession:
    Q9NVP1
    Secondary Accessions:
    • Q6GTZ9
    • Q6IAU4
    • Q92732
    • Q9BQB7

    Protein attributes for DDX18 Gene

    Size:
    670 amino acids
    Molecular mass:
    75407 Da
    Quaternary structure:
    • Interacts with NOL8; the interaction is RNA-dependent.
    SequenceCaution:
    • Sequence=CAA67295.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX18 Gene

neXtProt entry for DDX18 Gene

Selected DME Specific Peptides for DDX18 Gene

Q9NVP1:
  • RVGRTAR
  • VAARGLDI
  • KRTTTFF
  • KVEDLARISL
  • CTDVAARG
  • GVLKELM
  • TGSGKTLA
  • AARGLDIP
  • AKTGSGKT
  • FLIPAVE
  • ELGFLRYLK
  • MLFSATQT
  • PRNGTGV
  • DEADRIL
  • LEQGYVVC
  • TPGRLLD
  • SPTRELA
  • LVIDEAD
  • RQTMLFSAT
  • NYIDLPV
  • IIVATPGR
  • VATPGRL
  • YIHRVGR
  • TDVAARGLD

Post-translational modifications for DDX18 Gene

  • Ubiquitination at Lys 195 and Lys 571
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DDX18 Gene

Gene Families for DDX18 Gene

Suggested Antigen Peptide Sequences for DDX18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVP1

UniProtKB/Swiss-Prot:

DDX18_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
genes like me logo Genes that share domains with DDX18: view

Function for DDX18 Gene

Molecular function for DDX18 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable RNA-dependent helicase.

Enzyme Numbers (IUBMB) for DDX18 Gene

Gene Ontology (GO) - Molecular Function for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0004004 ATP-dependent RNA helicase activity TAS 8861962
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 16963496
genes like me logo Genes that share ontologies with DDX18: view
genes like me logo Genes that share phenotypes with DDX18: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX18 Gene

Localization for DDX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX18 Gene

Nucleus, nucleolus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX18 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA,IDA 20813266
GO:0005730 nucleolus IEA,IDA 16963496
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX18: view

Pathways & Interactions for DDX18 Gene

genes like me logo Genes that share pathways with DDX18: view

Pathways by source for DDX18 Gene

1 BioSystems pathway for DDX18 Gene

Gene Ontology (GO) - Biological Process for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
GO:0071392 cellular response to estradiol stimulus IEA --
genes like me logo Genes that share ontologies with DDX18: view

No data available for SIGNOR curated interactions for DDX18 Gene

Drugs & Compounds for DDX18 Gene

(3) Drugs for DDX18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for DDX18 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX18: view

Transcripts for DDX18 Gene

Unigene Clusters for DDX18 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 18:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX18 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for DDX18 Gene

GeneLoc Exon Structure for
DDX18
ECgene alternative splicing isoforms for
DDX18

Expression for DDX18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX18 Gene

This gene is overexpressed in Lung (9.0), Tlymphocyte (8.9), Peripheral blood mononuclear cells (8.3), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX18 Gene



Protein tissue co-expression partners for DDX18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX18 Gene:

DDX18

SOURCE GeneReport for Unigene cluster for DDX18 Gene:

Hs.744922
genes like me logo Genes that share expression patterns with DDX18: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX18 Gene

Orthologs for DDX18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX18 34 35
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
DDX18 34
  • 88.19 (n)
dog
(Canis familiaris)
Mammalia DDX18 34 35
  • 88.24 (n)
oppossum
(Monodelphis domestica)
Mammalia DDX18 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx18 34 16 35
  • 83.56 (n)
rat
(Rattus norvegicus)
Mammalia Ddx18 34
  • 81.89 (n)
chicken
(Gallus gallus)
Aves DDX18 34 35
  • 73.67 (n)
lizard
(Anolis carolinensis)
Reptilia DDX18 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx18 34
  • 67.82 (n)
Str.2227 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23801 34
zebrafish
(Danio rerio)
Actinopterygii ddx18 34 35
  • 66.67 (n)
sbcb155 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1047 34
fruit fly
(Drosophila melanogaster)
Insecta pit 36 34 35
  • 67.99 (n)
CG9630 36
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008601 34
  • 63.22 (n)
worm
(Caenorhabditis elegans)
Secernentea B0511.6 36 34 35
  • 61.57 (n)
ZK512.2 36
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR333C 34
  • 62.3 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09669g 34
  • 61.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAS1 34 35 37
  • 61.63 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18600 34
  • 59.68 (n)
rice
(Oryza sativa)
Liliopsida Os06g0535100 34
  • 60.16 (n)
Os.5799 34
barley
(Hordeum vulgare)
Liliopsida Hv.831 34
wheat
(Triticum aestivum)
Liliopsida Ta.6315 34
corn
(Zea mays)
Liliopsida Zm.4304 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 70 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes has1 34
  • 62.99 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09349 34
  • 60.04 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4575 34
Species where no ortholog for DDX18 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX18 Gene

ENSEMBL:
Gene Tree for DDX18 (if available)
TreeFam:
Gene Tree for DDX18 (if available)

Paralogs for DDX18 Gene

genes like me logo Genes that share paralogs with DDX18: view

No data available for Paralogs for DDX18 Gene

Variants for DDX18 Gene

Sequence variations from dbSNP and Humsavar for DDX18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035841 A breast cancer sample
rs10094 -- 117,831,137(+) GGTGG(C/T)GGTGC utr-variant-3-prime
rs10166458 -- 117,820,756(+) GTGAG(A/G)TTAAC intron-variant
rs10179772 -- 117,830,651(+) AACCA(A/G)GAAAG reference, missense
rs10490632 -- 117,821,509(-) TATAC(C/T)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX18 Gene

Variant ID Type Subtype PubMed ID
nsv2889 CNV insertion 18451855
nsv961874 CNV duplication 23825009
nsv961875 CNV duplication 23825009
nsv999434 CNV gain 25217958

Variation tolerance for DDX18 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.43; 94.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX18 Gene

Disorders for DDX18 Gene

Relevant External Links for DDX18

Genetic Association Database (GAD)
DDX18
Human Genome Epidemiology (HuGE) Navigator
DDX18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX18

No disorders were found for DDX18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX18 Gene

Publications for DDX18 Gene

  1. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. (PMID: 8861962) Grandori C. … Eisenman R.E. (EMBO J. 1996) 2 3 4 64
  2. Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer. (PMID: 20689807) Wang X. … Bell D.A. (PLoS ONE 2010) 3 46 64
  3. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S. … Rappsilber J. (Cell 2010) 3 4 64
  4. Cellular studies of MrDb (DDX18). (PMID: 18351129) Dubaele S. … ChA"ne P. (Oncol. Res. 2007) 3 22 64
  5. NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47. (PMID: 16963496) Sekiguchi T. … Nishimoto T. (Nucleic Acids Res. 2006) 3 4 64

Products for DDX18 Gene

Sources for DDX18 Gene

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