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Aliases for DDX18 Gene

Aliases for DDX18 Gene

  • DEAD-Box Helicase 18 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 18 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 18 (Myc-Regulated) 2 3
  • Myc-Regulated DEAD Box Protein 3 4
  • DEAD Box Protein 18 3 4
  • MrDb 3 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63

External Ids for DDX18 Gene

Previous GeneCards Identifiers for DDX18 Gene

  • GC02P115777
  • GC02P116493
  • GC02P118479
  • GC02P118667
  • GC02P118288
  • GC02P118572
  • GC02P110899
  • GC02P117837
  • GC02P117843

Summaries for DDX18 Gene

Entrez Gene Summary for DDX18 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX18 Gene

DDX18 (DEAD-Box Helicase 18) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include nucleic acid binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for DDX18 Gene

  • Probable RNA-dependent helicase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX18 Gene

Genomics for DDX18 Gene

Regulatory Elements for DDX18 Gene

Promoters for DDX18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX18 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX18 Gene

Chromosome:
2
Start:
117,814,650 bp from pter
End:
117,832,379 bp from pter
Size:
17,730 bases
Orientation:
Plus strand

Genomic View for DDX18 Gene

Genes around DDX18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX18 Gene

Proteins for DDX18 Gene

  • Protein details for DDX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVP1-DDX18_HUMAN
    Recommended name:
    ATP-dependent RNA helicase DDX18
    Protein Accession:
    Q9NVP1
    Secondary Accessions:
    • Q6GTZ9
    • Q6IAU4
    • Q92732
    • Q9BQB7

    Protein attributes for DDX18 Gene

    Size:
    670 amino acids
    Molecular mass:
    75407 Da
    Quaternary structure:
    • Interacts with NOL8; the interaction is RNA-dependent.
    SequenceCaution:
    • Sequence=CAA67295.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX18 Gene

neXtProt entry for DDX18 Gene

Proteomics data for DDX18 Gene at MOPED

Post-translational modifications for DDX18 Gene

  • Ubiquitination at Lys 195 and Lys 571
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DDX18

Domains & Families for DDX18 Gene

Gene Families for DDX18 Gene

Suggested Antigen Peptide Sequences for DDX18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVP1

UniProtKB/Swiss-Prot:

DDX18_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
genes like me logo Genes that share domains with DDX18: view

Function for DDX18 Gene

Molecular function for DDX18 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable RNA-dependent helicase.

Enzyme Numbers (IUBMB) for DDX18 Gene

Gene Ontology (GO) - Molecular Function for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004004 ATP-dependent RNA helicase activity TAS 8861962
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DDX18: view
genes like me logo Genes that share phenotypes with DDX18: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX18 Gene

Localization for DDX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX18 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX18 Gene COMPARTMENTS Subcellular localization image for DDX18 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for DDX18 Gene

Pathways & Interactions for DDX18 Gene

genes like me logo Genes that share pathways with DDX18: view

Pathways by source for DDX18 Gene

1 BioSystems pathway for DDX18 Gene

Gene Ontology (GO) - Biological Process for DDX18 Gene

None

No data available for SIGNOR curated interactions for DDX18 Gene

Drugs & Compounds for DDX18 Gene

(1) Drugs for DDX18 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(4) Additional Compounds for DDX18 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX18: view

Transcripts for DDX18 Gene

Unigene Clusters for DDX18 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 18:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX18 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for DDX18 Gene

GeneLoc Exon Structure for
DDX18
ECgene alternative splicing isoforms for
DDX18

Expression for DDX18 Gene

mRNA expression in normal human tissues for DDX18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX18 Gene

This gene is overexpressed in Lung (9.0), Tlymphocyte (8.9), Peripheral blood mononuclear cells (8.3), and CD8 Tcells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX18 Gene



SOURCE GeneReport for Unigene cluster for DDX18 Gene Hs.744922

genes like me logo Genes that share expression patterns with DDX18: view

Protein tissue co-expression partners for DDX18 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDX18 Gene

Orthologs for DDX18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX18 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX18 35
  • 88.19 (n)
  • 89.99 (a)
-- 36
  • 90 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DDX18 35
  • 88.24 (n)
  • 89.69 (a)
DDX18 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx18 35
  • 83.56 (n)
  • 87.71 (a)
Ddx18 16
Ddx18 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX18 35
  • 99.15 (n)
  • 98.36 (a)
DDX18 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx18 35
  • 81.89 (n)
  • 85.52 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX18 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX18 35
  • 73.67 (n)
  • 79.94 (a)
DDX18 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX18 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx18 35
  • 67.82 (n)
  • 76.69 (a)
Str.2227 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23801 35
zebrafish
(Danio rerio)
Actinopterygii ddx18 35
  • 66.67 (n)
  • 74.07 (a)
sbcb155 35
ddx18 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1047 35
fruit fly
(Drosophila melanogaster)
Insecta CG9630 37
  • 38 (a)
pit 37
  • 72 (a)
pit 35
  • 67.99 (n)
  • 78.59 (a)
pit 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008601 35
  • 63.22 (n)
  • 68.94 (a)
worm
(Caenorhabditis elegans)
Secernentea B0511.6 37
  • 67 (a)
ZK512.2 37
  • 30 (a)
B0511.6 35
  • 61.57 (n)
  • 64.48 (a)
B0511.6 36
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR333C 35
  • 62.3 (n)
  • 64.56 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09669g 35
  • 61.92 (n)
  • 62.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAS1 35
  • 61.63 (n)
  • 61.22 (a)
HAS1 36
  • 59 (a)
OneToOne
HAS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18600 35
  • 59.68 (n)
  • 58.27 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.831 35
rice
(Oryza sativa)
Liliopsida Os.5799 35
Os06g0535100 35
  • 60.16 (n)
  • 58.81 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6315 35
corn
(Zea mays)
Liliopsida Zm.4304 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4575 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09349 35
  • 60.04 (n)
  • 64.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes has1 35
  • 62.99 (n)
  • 63.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 70 (a)
OneToOne
Species with no ortholog for DDX18:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX18 Gene

ENSEMBL:
Gene Tree for DDX18 (if available)
TreeFam:
Gene Tree for DDX18 (if available)

Paralogs for DDX18 Gene

genes like me logo Genes that share paralogs with DDX18: view

No data available for Paralogs for DDX18 Gene

Variants for DDX18 Gene

Sequence variations from dbSNP and Humsavar for DDX18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1052637 - 117,817,639(-) CATTG(C/G)TTAAT reference, missense
rs10179772 - 117,830,651(+) AACCA(A/G)GAAAG reference, missense
VAR_035841 A breast cancer sample
rs571 -- 117,832,267(-) AGCAT(A/G/T)AACAT utr-variant-3-prime
rs7369 -- 117,832,232(+) GTTGG(C/T)ATTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDX18 Gene

Variant ID Type Subtype PubMed ID
nsv2889 CNV Insertion 18451855

Variation tolerance for DDX18 Gene

Residual Variation Intolerance Score: 82.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.43; 94.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX18 Gene

HapMap Linkage Disequilibrium report
DDX18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX18 Gene

Disorders for DDX18 Gene

Relevant External Links for DDX18

Genetic Association Database (GAD)
DDX18
Human Genome Epidemiology (HuGE) Navigator
DDX18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX18

No disorders were found for DDX18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX18 Gene

Publications for DDX18 Gene

  1. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. (PMID: 8861962) Grandori C. … Eisenman R.E. (EMBO J. 1996) 2 3 4 67
  2. Cellular studies of MrDb (DDX18). (PMID: 18351129) Dubaele S. … ChA"ne P. (Oncol. Res. 2007) 3 23
  3. Genomic interaction between ER and HMGB2 identifies DDX18 as a novel driver of endocrine resistance in breast cancer cells. (PMID: 25284587) Redmond A.M. … Young L.S. (Oncogene 2015) 3
  4. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for DDX18 Gene

Sources for DDX18 Gene

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