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Aliases for DDX18 Gene

Aliases for DDX18 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 18 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 18 (Myc-Regulated) 2 3
  • Myc-Regulated DEAD Box Protein 3 4
  • DEAD Box Protein 18 3 4
  • MrDb 3 4
  • ATP-Dependent RNA Helicase DDX18 3
  • EC 4
  • EC 3.6.1 64

External Ids for DDX18 Gene

Summaries for DDX18 Gene

Entrez Gene Summary for DDX18 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it is activated by Myc protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX18 Gene

DDX18 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 18) is a Protein Coding gene. Among its related pathways are Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include RNA binding and ATP-dependent RNA helicase activity.

UniProtKB/Swiss-Prot for DDX18 Gene

  • Probable RNA-dependent helicase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX18 Gene

Genomics for DDX18 Gene

Genomic Location for DDX18 Gene

117,814,650 bp from pter
117,832,379 bp from pter
17,730 bases
Plus strand

Genomic View for DDX18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX18 Gene

Regulatory Elements for DDX18 Gene

Proteins for DDX18 Gene

  • Protein details for DDX18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ATP-dependent RNA helicase DDX18
    Protein Accession:
    Secondary Accessions:
    • Q6GTZ9
    • Q6IAU4
    • Q92732
    • Q9BQB7

    Protein attributes for DDX18 Gene

    670 amino acids
    Molecular mass:
    75407 Da
    Quaternary structure:
    • Interacts with NOL8; the interaction is RNA-dependent.
    • Sequence=CAA67295.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DDX18 Gene

neXtProt entry for DDX18 Gene

Proteomics data for DDX18 Gene at MOPED

Post-translational modifications for DDX18 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys195 and Lys571

Other Protein References for DDX18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DDX18 Gene

Gene Families for DDX18 Gene

  • DDX :DEAD-boxes


  • Contains 1 helicase ATP-binding domain.:
    • Q9NVP1
  • Contains 1 helicase C-terminal domain.:
    • Q9NVP1
  • Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.:
    • Q9NVP1
genes like me logo Genes that share domains with DDX18: view

Function for DDX18 Gene

Molecular function for DDX18 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Probable RNA-dependent helicase

Enzyme Numbers (IUBMB) for DDX18 Gene

Gene Ontology (GO) - Molecular Function for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0004004 ATP-dependent RNA helicase activity TAS 8861962
GO:0005515 protein binding IPI 16963496
GO:0005524 ATP binding IEA --
GO:0008026 ATP-dependent helicase activity --
genes like me logo Genes that share ontologies with DDX18: view
genes like me logo Genes that share phenotypes with DDX18: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DDX18 Gene

Localization for DDX18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX18 Gene

Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for DDX18 Gene COMPARTMENTS Subcellular localization image for DDX18 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX18: view

Pathways for DDX18 Gene

genes like me logo Genes that share pathways with DDX18: view

Pathways by source for DDX18 Gene

1 BioSystems pathway for DDX18 Gene

Gene Ontology (GO) - Biological Process for DDX18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX18: view

Compounds for DDX18 Gene

(1) Novoseek inferred chemical compound relationships for DDX18 Gene

Compound -log(P) Hits PubMed IDs
oligonucleotide 26.1 1
genes like me logo Genes that share compounds with DDX18: view

Transcripts for DDX18 Gene

Unigene Clusters for DDX18 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX18 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP2: -
SP3: -

Relevant External Links for DDX18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDX18 Gene

mRNA expression in normal human tissues for DDX18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX18 Gene

SOURCE GeneReport for Unigene cluster for DDX18 Gene Hs.744922

genes like me logo Genes that share expressions with DDX18: view

Orthologs for DDX18 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX18 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDX18 36
  • 99.15 (n)
  • 98.36 (a)
DDX18 37
  • 98 (a)
(Bos Taurus)
Mammalia -- 37
  • 90 (a)
-- 37
  • 89 (a)
DDX18 36
  • 88.19 (n)
  • 89.99 (a)
(Canis familiaris)
Mammalia DDX18 36
  • 88.24 (n)
  • 89.69 (a)
DDX18 37
  • 90 (a)
(Mus musculus)
Mammalia Ddx18 36
  • 83.56 (n)
  • 87.71 (a)
Ddx18 16
Ddx18 37
  • 87 (a)
(Monodelphis domestica)
Mammalia DDX18 37
  • 84 (a)
(Rattus norvegicus)
Mammalia Ddx18 36
  • 81.89 (n)
  • 85.52 (a)
(Gallus gallus)
Aves DDX18 36
  • 73.67 (n)
  • 79.94 (a)
DDX18 37
  • 76 (a)
(Anolis carolinensis)
Reptilia DDX18 37
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23801 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx18 36
  • 67.82 (n)
  • 76.69 (a)
Str.2227 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1047 36
(Danio rerio)
Actinopterygii ddx18 36
  • 66.67 (n)
  • 74.07 (a)
ddx18 37
  • 72 (a)
sbcb155 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008601 36
  • 63.22 (n)
  • 68.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta pit 36
  • 67.99 (n)
  • 78.59 (a)
pit 37
  • 58 (a)
CG9630 38
  • 38 (a)
pit 38
  • 72 (a)
(Caenorhabditis elegans)
Secernentea B0511.6 36
  • 61.57 (n)
  • 64.48 (a)
B0511.6 37
  • 60 (a)
B0511.6 38
  • 67 (a)
ZK512.2 38
  • 30 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR333C 36
  • 62.3 (n)
  • 64.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HAS1 36
  • 61.63 (n)
  • 61.22 (a)
HAS1 37
  • 59 (a)
HAS1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A09669g 36
  • 61.92 (n)
  • 62.63 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18600 36
  • 59.68 (n)
  • 58.27 (a)
(Hordeum vulgare)
Liliopsida Hv.831 36
(Zea mays)
Liliopsida Zm.4304 36
(Oryza sativa)
Liliopsida Os.5799 36
Os06g0535100 36
  • 60.16 (n)
  • 58.81 (a)
(Triticum aestivum)
Liliopsida Ta.6315 36
bread mold
(Neurospora crassa)
Ascomycetes NCU09349 36
  • 60.04 (n)
  • 64.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes has1 36
  • 62.99 (n)
  • 63.47 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4575 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 70 (a)
Species with no ortholog for DDX18:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DDX18 Gene

Gene Tree for DDX18 (if available)
Gene Tree for DDX18 (if available)

Paralogs for DDX18 Gene

Selected SIMAP similar genes for DDX18 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DDX18: view

No data available for Paralogs for DDX18 Gene

Variants for DDX18 Gene

Sequence variations from dbSNP and Humsavar for DDX18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs571 -- 117,832,267(-) AGCAT(A/G/T)AACAT utr-variant-3-prime
rs7369 -- 117,832,232(+) GTTGG(C/T)ATTTT utr-variant-3-prime
rs10094 -- 117,831,137(+) GGTGG(C/T)GGTGC utr-variant-3-prime
rs13024 -- 117,832,321(+) GTAAC(C/T)AGCTT utr-variant-3-prime
rs15975 -- 117,831,046(+) TTGTA(C/T)CTTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDX18 Gene

Variant ID Type Subtype PubMed ID
nsv2889 CNV Insertion 18451855

Relevant External Links for DDX18 Gene

HapMap Linkage Disequilibrium report

Disorders for DDX18 Gene

(1) Novoseek inferred disease relationships for DDX18 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 4

Relevant External Links for DDX18

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DDX18: view

No data available for UniProtKB/Swiss-Prot for DDX18 Gene

Publications for DDX18 Gene

  1. Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo. (PMID: 8861962) Grandori C. … Eisenman R.E. (EMBO J. 1996) 2 3 4
  2. Cellular studies of MrDb (DDX18). (PMID: 18351129) Dubaele S. … ChA"ne P. (Oncol. Res. 2007) 3 23
  3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DDX18 Gene

Sources for DDX18 Gene

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