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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX17 Gene

protein-coding   GIFtS: 59
GCID: GC22M038879

DEAD (Asp-Glu-Ala-Asp) box helicase 17

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD),...)
 Explore 7 diseases affiliated with
DDX17 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DDX17    

Aliases
for DDX17 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 171 2     RH702 5
P721 2 5     Probable ATP-Dependent RNA Helicase DDX172
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 171 2     EC 3.6.4.133
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 17 (72kD)1 2     DEAD Box Protein 173
DEAD Box Protein P722 3     EC 3.6.18
RNA-Dependent Helicase P722 3     

External Ids:    HGNC: 27401   Entrez Gene: 105212   Ensembl: ENSG000001002017   OMIM: 6084695   UniProtKB: Q928413   
ORGUL members:         
NONCODE:n338076    

Export aliases for DDX17 gene to outside databases

Previous GC identifers: GC22M035496 GC22M037122 GC22M037124 GC22M037203 GC22M021845


Summaries
for DDX17 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DDX17:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation
initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution
patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular
growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species,
but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any
other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the
use of alternative translation initiation codons, including a non-AUG (CUG) start codon. (provided by RefSeq, Apr
2011)

UniProtKB/Swiss-Prot: DDX17_HUMAN, Q92841
Function: RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for
estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to
activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for
zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation

Gene Wiki entry for DDX17


Genomic Views
for DDX17 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX17 gene promoter:
         TBP   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDX17 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

DDX17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX17 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M038879:  view genomic region     (about GC identifiers)

Start:
 38,879,443 bp from pter      End:
 38,903,665 bp from pter
Size:
 24,223 bases      Orientation:
 minus strand

Proteins
for DDX17 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DDX17_HUMAN, Q92841 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX17  
Size: 729 amino acids; 80272 Da
Subunit: Interacts with ESR1. Interacts with NCOA1, NCOA2, NCOA3, TP53 and HDAC1. Self-associates. Interacts with DDX5.
Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner. Interacts with
ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3 and EXOSC5 only in the presence of
ZC3HAV1 in an RNA-independent manner
Subcellular location: Nucleus. Nucleus, nucleolus
Secondary accessions: B1AHM0 Q69YT1 Q6ICD6
Alternative splicing, Alternative initiation: 4 isoforms:  Q92841-4   Q92841-1   Q92841-2   Q92841-3   (Produced by alternative splicing of isoform 2. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX17: NX_Q92841

Post-translational modifications:

  • Sumoylation significantly increases stability, it also promotes interaction with HDAC11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92841

    • 4/34 DME Specific Peptides for DDX17 (Q92841) (see all 34)
     DMGFEPQ  LAPTREL  YGGAPKG  DEADRML 

    DDX17 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091974.1  NP_006377.2  

    ENSEMBL proteins: 
     ENSP00000380033   ENSP00000385536   ENSP00000371046   ENSP00000400766  

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    OriGene Protein Over-expression Lysate (see all 3): DDX17
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    Novus Biologicals DDX17 Proteins
    Novus Biologicals DDX17 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DDX17

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA11250900
    GO:0005730nucleolus IEA--


    DDX17 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DDX17

    Protein Domains /
    Families
    for DDX17 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DDX17 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q92841

    ProtoNet protein and cluster: Q92841

    1 Blocks protein family: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX17_HUMAN, Q92841
    Similarity: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for DDX17 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DDX17_HUMAN, Q92841
    Function: RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for
    estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to
    activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for
    zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for DDX17:
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

    miRNA
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    hsa-miR-520d-5p hsa-miR-875-5p hsa-miR-449a hsa-miR-421 hsa-miR-570 hsa-miR-1297 hsa-miR-3162-5p hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: DDX17 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003713transcription coactivator activity IDA11250900
    GO:0003723RNA binding IEA--
    GO:0003724RNA helicase activity TAS8871553
    GO:0005515protein binding IPI--


    DDX17 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DDX17:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ddx17):
     cardiovascular system  cellular  growth/size  mortality/aging 

    DDX17 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DDX17 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		Estrogen Pathway0.55

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DDX17
        Estrogen Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDX17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/914 Interacting proteins for DDX17 (Q928411, 2, 3 ENSP000003800334) via UniProtKB, MINT, STRING, and/or I2D (see all 914)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX5P178442, 3, ENSP000002257924MINT-7945693 MINT-7947479 MINT-8395092 MINT-8329598 MINT-8338410 I2D: score=3 STRING: ENSP00000225792
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    SNRNP70P086212, 3, ENSP000002214484MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000221448
    HNRNPH1P319432, 3, ENSP000003491684MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349168
    SF3A2Q154282, 3, ENSP000002214944MINT-5206241 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006396RNA processing TAS8871553
    GO:0009791post-embryonic development ----
    GO:0033148positive regulation of intracellular estrogen receptor signaling pathway IDA11250900
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA11250900


    DDX17 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DDX17 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DDX17 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX17
    1 Novoseek chemical compound relationship for DDX17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 15.8 3 12193588 (3)

    Search CenterWatch for drugs/clinical trials and news about DDX17 

    Transcripts
    for DDX17 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDX17 gene (4 alternative transcripts): 
    NM_001098504.1  NM_006386.4  NM_001098505.1  NM_030881.3  

    Unigene Cluster for DDX17:

    DEAD (Asp-Glu-Ala-Asp) box helicase 17
    Hs.705517  [show with all ESTs]
    Unigene Representative Sequence: NM_001098504
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396821(uc003avy.4 uc003avx.4) ENST00000431312 ENST00000216019
    ENST00000403230 ENST00000475004 ENST00000432525(uc011anu.2) ENST00000497196
    ENST00000477112 ENST00000467279 ENST00000479734 ENST00000381633 ENST00000444597(uc003avw.4)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX17
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate DDX17 (see all 30):
    hsa-miR-520d-5p hsa-miR-875-5p hsa-miR-449a hsa-miR-421 hsa-miR-570 hsa-miR-1297 hsa-miR-3162-5p hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: DDX17 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX17 (see all 7)
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209595.1 AF131750.1 AK024985.1 AK074224.1 AK303049.1 AL080113.1 BC000595.2 BC029553.1 
    BC045747.1 CR456432.1 U59321.1 

    24/52 DOTS entries (see all 52):

    DT.100663116  DT.75132717  DT.100677201  DT.91768223  DT.100677206  DT.91851967  DT.92004561  DT.95356633 
    DT.100642240  DT.120651569  DT.100677210  DT.92455815  DT.100677208  DT.120651598  DT.91989790  DT.91768219 
    DT.100677202  DT.120651559  DT.455563  DT.120651479  DT.120651588  DT.120651541  DT.99927997  DT.99939757 

    24/1620 AceView cDNA sequences (see all 1620):

    AA283101 BM549305 AA232090 H37885 BM830535 AU118552 AA332350 AI520719 
    AA902423 T59404 BQ015073 AA573697 BE670454 AI523578 AL080113 AI673379 
    CA952476 U59321 AW613006 AI299367 AA769329 AI312694 AA338200 AI474027 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DDX17 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
    SP1:                                                                    -           -     -     -     -     -                                 
    SP2:                                                                    -           -     -     -     -     -                                 
    SP3:                                                                    -           -                                                         
    SP4:                                                                    -                                                                     
    SP5:                                                                    -           -     -           -     -                                 


    ECgene alternative splicing isoforms for DDX17

    Expression
    for DDX17 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTGAAACTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DDX17 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    EyeRetinaEye
    KidneyMetanephrosKidney
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Reproductive SystemVas DeferensReproductive System
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DDX17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX17

    SOURCE GeneReport for Unigene cluster: Hs.705517

    UniProtKB/Swiss-Prot: DDX17_HUMAN, Q92841
    Tissue specificity: Ubiquitous

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    In Situ
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    Orthologs
    for DDX17 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX17 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DDX171 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 80.37(n)
    91.43(a)    		   418024  XM_416260.3  XP_416260.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DDX176
    		 --
    		 89(a)
    		 1 ↔ 1
    		 GL343460.1(631133-647580)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC054236.12   -- 77.48(n)    BC054236.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5567641 similar to Probable RNA-dependent helicase p72 (DEAD-box more 69.39(n)
    78.62(a)    		   556764  XM_001923795.2  XP_001923830.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG100773
    Rm621    		 RNA helicase3
    CG10279-PA1    		 67(a)
    (best of 4)3
    59.16(n)1
    62.25(a)1    		   407391  NM_079519.21  NP_524243.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea F58E10.33 ATP-dependent helicase (DEAD box) 60(a)
    (best of 2)    		   V(14011697-14014413)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G551501 DEAD-box ATP-dependent RNA helicase 20 61.34(n)
    61.56(a)    		   841958  NM_104388.3  NP_175911.1 
    rice
    (Oryza sativa)    		 Liliopsida NM_188251.12   -- 73(n)    NM_188251.1 


    ENSEMBL Gene Tree for DDX17 (if available)
    TreeFam Gene Tree for DDX17 (if available) 

    Paralogs
    for DDX17 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX17 gene
    DDX12  DDX412  DDX52  DDX432  DDX532  
    18/26 SIMAP similar genes for DDX17 using alignment to 4 protein entries:     DDX17_HUMAN (see all proteins) (see all similar genes):
    DKFZp686J01190    DDX5    DDX53    DDX43    DDX46    DDX39B
    DKFZp547B159    BAT1    DDX41    DDX59    EIF4A2    DDX42
    DKFZp564G1016    E4-DBP    MST162    DDX4    EIF4A1    DDX39A

    DDX17 for paralogs           About GeneDecksing



    Genomic Variants
    for DDX17 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/450 NCBI SNPs in DDX17 are shown (see all 450)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs169989891,2
    		C,F,H,--21845535(-) TGATAC/TCATCA 2 -- ut3112Minor allele frequency- T:0.03EU NS EA NA 1706
    rs731571361,2
    		C,--21846066(+) CTTTCA/GAGAGC 2 -- ut310--------
    rs7450561,2
    		H--21847194(+) GGGAAG/AAAATA 2 -- ut315Minor allele frequency- A:0.00MN NS EA 604
    rs786188501,2
    		C,--21847860(+) AAAATA/TAAAAA 2 -- ut310--------
    rs2013129451,2
    		C--21848102(+) GGCTGG/TGGCTG 4 P syn10--------
    rs1116740281,2
    		C,F--21848189(+) GCTCCA/GTAAGT 4 Y syn11Minor allele frequency- G:0.00NA 4552
    rs57571051,2
    		--21849183(+) ctccaA/Gtctgg 2 -- int10--------
    rs104278731,2
    		C,--21849382(+) CCTCAA/GCTAGG 2 -- int10--------
    rs2018845791,2
    		C--21850388(+) GCTGTA/GGAATC 2 -- int10--------
    rs169990011,2
    		C,F,H,--21850485(+) TCAGAC/TGCAAA 2 -- int17Minor allele frequency- T:0.01NA NS 660

    HapMap Linkage Disequilibrium report for DDX17 (38879443 - 38903665 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DDX17: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for DDX17 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DDX17 for disorders           About GeneDecksing

    OMIM gene information: 608469    OMIM disorders: --

    7 diseases for DDX17:    About MalaCards
    bipolar disorder    down syndrome    colon cancer    breast cancer
    sarcoma    schizophrenia    malaria


    Export disorders for DDX17 gene to outside databases

    Publications
    for DDX17 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX17 gene, integrated from 9 sources (see all 98):
    (articles sorted by number of sources associating them with DDX17)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. (PubMed id 17226766)1, 2, 3, 9 Shin S. and Janknecht R. (2007)
    2. p72: a human nuclear DEAD box protein highly related to p68. (PubMed id 8871553)1, 2, 3, 9 Lamm G.M.... Lamond A.I. (1996)
    3. Sumoylation of p68 and p72 RNA helicases affects prot ein stability and transactivation potential. (PubMed id 19995069)1, 2, 9 Mooney S.M....Janknecht R. (2010)
    4. The DEAD-box protein p72 regulates ERalpha-/oestrogen -dependent transcription and cell growth, and is associated with improved survi val in ERalpha-positive breast cancer. (PubMed id 19718048)1, 2, 9 Wortham N.C....Fuller-Pace F.V. (2009)
    5. p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. (PubMed id 18334637)1, 2, 9 Chen G....Gao G. (2008)
    6. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. (PubMed id 15298701)1, 2, 9 Wilson B.J....Fuller-Pace F.V. (2004)
    7. The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicase. (PubMed id 11675387)1, 2, 9 Uhlmann-Schiffler H....Stahl H. (2002)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. The RNA helicases p68/p72 and the noncoding RNA SRA a re coregulators of MyoD and skeletal muscle differentiation. (PubMed id 17011493)1, 2 Caretti G....Sartorelli V. (2006)
    10. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)

    External Searches for DDX17 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing DDX17 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10521 HGNC: 2740 AceView: DDX17 Ensembl:ENSG00000100201 euGenes: HUgn10521
    ECgene: DDX17 H-InvDB: DDX17

    Other Databases showing DDX17 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDX17 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX17 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DDX17 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDX17 gene:
    Search GeneIP for patents involving DDX17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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