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DDX17 Gene

protein-coding   GIFtS: 61
GCID: GC22M038879

DEAD (Asp-Glu-Ala-Asp) Box Helicase 17

(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD),...)
  Search for DDX17
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Helicase 171 2     RH702 5
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 171 2     Probable ATP-Dependent RNA Helicase DDX172
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 17 (72kD)1 2     EC 3.6.4.133
DEAD Box Protein P722 3     DEAD Box Protein 173
RNA-Dependent Helicase P722 3     EC 3.6.18
P722 5     

External Ids:    HGNC: 27401   Entrez Gene: 105212   Ensembl: ENSG000001002017   OMIM: 6084695   UniProtKB: Q928413   
ORGUL members:         

Export aliases for DDX17 gene to outside databases

Previous GC identifers: GC22M035496 GC22M037122 GC22M037124 GC22M037203 GC22M021845


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX17 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on
their distribution patterns, some members of this family are believed to be involved in embryogenesis,
spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase
activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more
closely related to each other than to any other member of the DEAD box family. This gene can encode multiple
isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a
non-AUG (CUG) start codon. (provided by RefSeq, Apr 2011)

GeneCards Summary for DDX17 Gene:
DDX17 (DEAD (Asp-Glu-Ala-Asp) box helicase 17) is a protein-coding gene. GO annotations related to this gene include RNA binding and ATP-dependent helicase activity. An important paralog of this gene is DDX46.

UniProtKB/Swiss-Prot: DDX17_HUMAN, Q92841
Function: RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for
estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to
activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for
zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation

Gene Wiki entry for DDX17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX17 gene promoter:
         TBP   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX17 promoter sequence
   Search Chromatin IP Primers for DDX17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

DDX17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX17 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M038879:  view genomic region     (about GC identifiers)

Start:
38,879,443 bp from pter      End:
38,903,665 bp from pter
Size:
24,223 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDX17_HUMAN, Q92841 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX17  
Size: 729 amino acids; 80272 Da
Subunit: Interacts with ESR1. Interacts with NCOA1, NCOA2, NCOA3, TP53 and HDAC1. Self-associates. Interacts with
DDX5. Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner.
Interacts with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3 and EXOSC5
only in the presence of ZC3HAV1 in an RNA-independent manner
Secondary accessions: B1AHM0 Q69YT1 Q6ICD6
Alternative splicing, Alternative initiation: 4 isoforms:  Q92841-4   Q92841-1   Q92841-2   Q92841-3   (Produced by alternative splicing of isoform 2. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDX17: NX_Q92841

Explore proteomics data for DDX17 at MOPED

Post-translational modifications: 

  • Sumoylation significantly increases stability, it also promotes interaction with HDAC11
  • Ubiquitination2 at Lys42, Lys50, Lys53, Lys190, Lys195, Lys205, Lys282, Lys373, Lys389, Lys436,
                                 Lys449, Lys468
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX17 (Q92841) (see all 34)
     DMGFEPQ  LAPTREL  YGGAPKG  DEADRML 


    See DDX17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091974.1  NP_006377.2  

    ENSEMBL proteins: 
     ENSP00000380033   ENSP00000385536   ENSP00000371046   ENSP00000400766  

    DDX17 Human Recombinant Protein Products:

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    Novus Biologicals DDX17 Proteins
    Novus Biologicals DDX17 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX17

     
    Search eBioscience for Proteins for DDX17 

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    LSBio Antibodies in human, mouse, rat for DDX17

    DDX17 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDX17
    Cloud-Clone Corp. CLIAs for DDX17
    Search eBioscience for ELISAs for DDX17 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 6):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q92841

    ProtoNet protein and cluster: Q92841

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX17_HUMAN, Q92841
    Similarity: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX17_HUMAN, Q92841
    Function: RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for
    estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to
    activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for
    zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for DDX17:
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003713transcription coactivator activity IDA11250900
    GO:0003723RNA binding TAS8871553
    GO:0003724RNA helicase activity TAS8871553
    GO:0004386helicase activity ----
         
    Find genes that share ontologies with DDX17           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DDX17:
     Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ddx17):
     cardiovascular system  cellular  growth/size/body  mortality/aging 

    Find genes that share phenotypes with DDX17           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDX17
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX17
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    miRNA
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    miRTarBase miRNAs that target DDX17:
    hsa-mir-378c (MIRT052829), hsa-mir-744-5p (MIRT037628), hsa-mir-106b-5p (MIRT044259), hsa-mir-331-3p (MIRT043487), hsa-mir-155-5p (MIRT020898), hsa-mir-27b-3p (MIRT046202), hsa-let-7b-5p (MIRT051884), hsa-mir-92a-3p (MIRT049106), hsa-mir-18a-3p (MIRT040859), hsa-mir-145-5p (MIRT006903)

    Block miRNA regulation of human, mouse, rat DDX17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDX17 (see all 30):
    hsa-miR-520d-5p hsa-miR-875-5p hsa-miR-449a hsa-miR-421 hsa-miR-570 hsa-miR-1297 hsa-miR-3162-5p hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDDX17 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DDX17
    Predesigned siRNA for gene silencing in human, mouse, rat DDX17

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): DDX17 (NM_006386)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX17
    Addgene plasmids for DDX17 

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DDX17 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDX17_HUMAN, Q92841: Nucleus. Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IEA--

    Find genes that share ontologies with DDX17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDX17 About    
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Estrogen Pathway0.55

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DDX17
        Estrogen Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX17
    Interactions:

        GeneGlobe Interaction Network for DDX17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX17 (Q928411, 2, 3 ENSP000003800334) via UniProtKB, MINT, STRING, and/or I2D (see all 1065)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX5P178442, 3, ENSP000002257924MINT-7945693 MINT-7947479 MINT-8395092 MINT-8329598 MINT-8338410 I2D: score=3 STRING: ENSP00000225792
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000370083
    SNRNP70P086212, 3, ENSP000002214484MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000221448
    HNRNPH1P319432, 3, ENSP000003491684MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349168
    SF3A2Q154282, 3, ENSP000002214944MINT-5206241 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process TAS8871553
    GO:0006351transcription, DNA-templated IEA--
    GO:0006396RNA processing TAS8871553
    GO:0009791post-embryonic development ----
    GO:0033148positive regulation of intracellular estrogen receptor signaling pathway IDA11250900

    Find genes that share ontologies with DDX17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX17

    1 Novoseek inferred chemical compound relationship for DDX17 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 15.8 3 12193588 (3)



    Find genes that share compounds with DDX17           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX17 gene (4 alternative transcripts): 
    NM_001098504.1  NM_006386.4  NM_001098505.1  NM_030881.3  

    Unigene Cluster for DDX17:

    DEAD (Asp-Glu-Ala-Asp) box helicase 17
    Hs.528305  [show with all ESTs]
    Unigene Representative Sequence: NM_001098504
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396821(uc003avy.4 uc003avx.4) ENST00000431312 ENST00000216019
    ENST00000403230 ENST00000475004 ENST00000432525(uc011anu.2) ENST00000497196
    ENST00000477112 ENST00000467279 ENST00000479734 ENST00000381633 ENST00000444597(uc003avw.4)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DDX17 (see all 30):
    hsa-miR-520d-5p hsa-miR-875-5p hsa-miR-449a hsa-miR-421 hsa-miR-570 hsa-miR-1297 hsa-miR-3162-5p hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidDDX17 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): DDX17 (NM_006386)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX17
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX17
    Addgene plasmids for DDX17 
    Primer
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    OriGene qPCR primer pairs and template standards for DDX17
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX17
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDX17
      QuantiTect SYBR Green Assays in human, mouse, rat DDX17
      QuantiFast Probe-based Assays in human, mouse, rat DDX17

    Additional mRNA sequence: 

    AB209595.1 AF131750.1 AK024985.1 AK074224.1 AK303049.1 AL080113.1 BC000595.2 BC029553.1 
    BC045747.1 CR456432.1 U59321.1 

    Selected DOTS entries (see all 63):

    DT.100663116  DT.75132717  DT.100677201  DT.91851967  DT.91768223  DT.100677206  DT.92455815  DT.92004561 
    DT.100642240  DT.100677210  DT.95356633  DT.120651569  DT.100677202  DT.100677208  DT.120651598  DT.91989790 
    DT.120651559  DT.120651479  DT.120651491  DT.91768219  DT.455563  DT.87017542  DT.120651588  DT.99939757 

    Selected AceView cDNA sequences (see all 1620):

    AU118552 AI520719 AI523578 AI673379 T59404 U59321 AI678437 AI913930 
    AI361499 H04237 NM_006386 AV650587 BP362936 CR608668 CA943588 AA860969 
    AI630564 AA364467 AV650520 BE858382 BM833275 AA332144 BE698286 CA440072 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDX17 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
    SP1:                                                                    -           -     -     -     -     -                                 
    SP2:                                                                    -           -     -     -     -     -                                 
    SP3:                                                                    -           -                                                         
    SP4:                                                                    -                                                                     
    SP5:                                                                    -           -     -           -     -                                 


    ECgene alternative splicing isoforms for DDX17

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DDX17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGAAACTC
    DDX17 Expression
    About this image


    DDX17 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Vas Deferens
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Retina
    DDX17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528305

    UniProtKB/Swiss-Prot: DDX17_HUMAN, Q92841
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for DDX17
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX17 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx171 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 171, 5 90.15(n)1
    98.77(a)1
      15 (37.77 cM)5
    670401  NM_001040187.11  NP_001035277.11 
     795277075 
    chicken
    (Gallus gallus)
    Aves DDX171 DEAD (Asp-Glu-Ala-Asp) box helicase 17 79.42(n)
    90.64(a)
      418024  XM_416260.4  XP_416260.2 
    lizard
    (Anolis carolinensis)
    Reptilia DDX176
    DEAD (Asp-Glu-Ala-Asp) box helicase 17
    90(a)
    1 ↔ 1
    GL343460.1(630869-648061)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054236.12   -- 77.48(n)    BC054236.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5567641 probable ATP-dependent RNA helicase DDX17-like 69.93(n)
    79.07(a)
      556764  XM_001923795.3  XP_001923830.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100773 RNA helicase 67(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea F58E10.31 , 3 ATP-dependent helicase (DEAD box)3
    F58E10.31
    60(a)
    (best of 2)3
    59.56(n)1
    60.77(a)1
      V(14011697-14014413)3
    1798971  NM_001047669.31  NP_001041134.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DBP26
    Essential ATP-dependent RNA helicase of the DEAD-b...
    55(a)
    1 → many
    XIV(413639-416281) YNL112W
    soybean
    (Glycine max)
    eudicotyledons Gma.61212 Transcribed sequence with moderate similarity to protein more 72.53(n)    BM885917.1 
    rice
    (Oryza sativa)
    Liliopsida NM_188251.12   -- 73(n)    NM_188251.1 


    ENSEMBL Gene Tree for DDX17 (if available)
    TreeFam Gene Tree for DDX17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX17 gene
    DDX462  DDX52  DDX422  DDX432  DDX532  
    Selected SIMAP similar genes for DDX17 using alignment to 4 protein entries:     DDX17_HUMAN (see all proteins) (see all similar genes):
    DKFZp686J01190    DDX5    DDX53    DDX43    DDX46    DKFZp547B159
    DDX41    DDX59    EIF4A2    DDX42    DKFZp564G1016    E4-DBP
    MST162    EIF4A1    DDX4    DDX39A    DDX47    DDX54

    Find genes that share paralogs with DDX17           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX17 (see all 624)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58453811,2
    C--21846138(+) CCCAG-/AATTTG 2 -- ut311Minor allele frequency- A:0.50NA 2
    rs58453831,2
    C--21846290(+) AAGAT-/A/GGGGGG 4 -- ut31 trp32NA CSA 4
    rs2021280261,2
    --21861564(+) AAATG-/AAAGAAGT 2 -- int10--------
    rs2018797671,2
    C--21861567(-) AACTTC/TTTTCA 2 -- int10--------
    rs1384511,2
    C--21862223(+) AAAAAAA/-GCCAA 2 -- int1 trp31Minor allele frequency- -:0.00NA 2
    rs360248481,2
    C--21864589(+) AAGAC-/TTAT  
            
    TTAAG
    2 -- int10--------
    rs680479871,2
    C--21864589(+) AAGACTTAT/-  
            
    TTAAG
    2 -- int11Minor allele frequency- -:0.50NA 2
    rs675368661,2
    C--21864592(+) ACTTA-/TTTA  
            
    AGGCT
    2 -- int10--------
    rs776367901,2
    C--21864592(+) ACTTAA/TTTAAG 2 -- int10--------
    rs802806551,2
    C--21864593(+) CTTATG/TTAAGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for DDX17 (38879443 - 38903665 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DDX17:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834195CNV Loss17160897
    nsv915066CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDX17
    DNA2.0 Custom Variant and Variant Library Synthesis for DDX17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608469    OMIM disorders: --


    Find genes that share disorders with DDX17           About GenesLikeMe


    Export disorders for DDX17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX17 gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with DDX17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. (PubMed id 17226766)1, 2, 3, 9 Shin S. and Janknecht R. (J. Cell. Biochem. 2007)
    2. p72: a human nuclear DEAD box protein highly related to p68. (PubMed id 8871553)1, 2, 3, 9 Lamm G.M.... Lamond A.I. (Nucleic Acids Res. 1996)
    3. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. (PubMed id 19995069)1, 2, 9 Mooney S.M.... Janknecht R. (Biochemistry 2010)
    4. The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. (PubMed id 19718048)1, 2, 9 Wortham N.C.... Fuller-Pace F.V. (Oncogene 2009)
    5. p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. (PubMed id 18334637)1, 2, 9 Chen G.... Gao G. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. (PubMed id 15298701)1, 2, 9 Wilson B.J....Fuller-Pace F.V. (BMC Mol. Biol. 2004)
    7. The mRNA of DEAD box protein p72 is alternatively translated into an 82-kDa RNA helicase. (PubMed id 11675387)1, 2, 9 Uhlmann-Schiffler H.... Stahl H. (J. Biol. Chem. 2002)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    9. The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation. (PubMed id 17011493)1, 2 Caretti G....Sartorelli V. (Dev. Cell 2006)
    10. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10521 HGNC: 2740 AceView: DDX17 Ensembl:ENSG00000100201 euGenes: HUgn10521
    ECgene: DDX17 H-InvDB: DDX17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDX17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDX17 gene:
    Search GeneIP for patents involving DDX17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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