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Aliases for DDX17 Gene

Aliases for DDX17 Gene

  • DEAD-Box Helicase 17 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 17 (72kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 17 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 17 2 3
  • RNA-Dependent Helicase P72 3 4
  • DEAD Box Protein P72 3 4
  • Probable ATP-Dependent RNA Helicase DDX17 3
  • DEAD Box Protein 17 4
  • EC 3.6.4.13 4
  • EC 3.6.1 61
  • RH70 3
  • P72 3

External Ids for DDX17 Gene

Previous GeneCards Identifiers for DDX17 Gene

  • GC22M035496
  • GC22M037122
  • GC22M037124
  • GC22M037203
  • GC22M038879
  • GC22M021845

Summaries for DDX17 Gene

Entrez Gene Summary for DDX17 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

GeneCards Summary for DDX17 Gene

DDX17 (DEAD-Box Helicase 17) is a Protein Coding gene. Among its related pathways are GPCR Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MIR5047.

UniProtKB/Swiss-Prot for DDX17 Gene

  • RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.

Gene Wiki entry for DDX17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX17 Gene

Genomics for DDX17 Gene

Regulatory Elements for DDX17 Gene

Enhancers for DDX17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F038422 0.7 Ensembl ENCODE 4.6 +83.8 83798 3.0 KLF17 FEZF1 RARA ZNF366 SCRT2 ETV6 EGR2 ZNF263 SP3 USF2 CSNK1E KDELR3 ENSG00000244627 LOC400927-CSNK1E KCNJ4 TAB1 CBY1 SOX10 POLR2F ENSG00000230912
GH22F039462 1.3 FANTOM5 Ensembl ENCODE 4.4 -961.6 -961580 14.5 HDGF PKNOX1 MLX ZFP64 ARID4B DMAP1 YY1 ZNF143 ZNF207 SP5 ENSG00000272834 SNORD83B TAB1 ENSG00000228274 PRDX3P1 MGAT3 ENSG00000227413 CBY1 SYNGR1 SNORD83A
GH22F038950 1.1 FANTOM5 Ensembl ENCODE 4.2 -445.6 -445642 5.4 HDGF PKNOX1 ZNF2 GLIS2 ZNF766 ZNF263 SP3 NFIL3 SMARCA4 GLIS1 APOBEC3B SUN2 APOBEC3A GTPBP1 APOBEC3B-AS1 DNAL4 JOSD1 APOBEC3D DDX17 LOC105373033
GH22F038966 1.1 FANTOM5 Ensembl ENCODE 3.8 -459.9 -459941 2.8 CTCF HDAC1 ESRRA ATF1 TAL1 ZIC2 ZNF316 POLR2A ZNF547 NFE2 APOBEC3A GTPBP1 SUN2 APOBEC3B-AS1 JOSD1 DDX17 LOC105373033
GH22F038940 0.9 FANTOM5 Ensembl ENCODE 2.3 -434.7 -434741 3.2 HDGF PKNOX1 TBL1XR1 ZFP64 ZBTB40 ZNF335 ZNF121 EGR1 ELK1 ZNF366 APOBEC3A ENSG00000228274 CBX6 APOBEC3B JOSD1 SUN2 GTPBP1 DDX17 ENSG00000235209
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DDX17 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX17 Gene

Chromosome:
22
Start:
38,483,438 bp from pter
End:
38,507,660 bp from pter
Size:
24,223 bases
Orientation:
Minus strand

Genomic View for DDX17 Gene

Genes around DDX17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX17 Gene

Proteins for DDX17 Gene

  • Protein details for DDX17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92841-DDX17_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX17
    Protein Accession:
    Q92841
    Secondary Accessions:
    • B1AHM0
    • Q69YT1
    • Q6ICD6

    Protein attributes for DDX17 Gene

    Size:
    729 amino acids
    Molecular mass:
    80272 Da
    Quaternary structure:
    • Interacts with ESR1. Interacts with NCOA1, NCOA2, NCOA3, TP53 and HDAC1. Self-associates. Interacts with DDX5. Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner. Interacts with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3 and EXOSC5 only in the presence of ZC3HAV1 in an RNA-independent manner.

    Alternative splice isoforms for DDX17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX17 Gene

Selected DME Specific Peptides for DDX17 Gene

Q92841:
  • EDYVHRIGRT
  • MRRDGWPAM
  • DMGFEPQ
  • YGGAPKG
  • DEADRML
  • VASRGLD
  • PTRELAQQ
  • TGSGKTLA
  • VLDEADRM
  • TDVASRG
  • QLAEDFL
  • KKFGNPGE
  • LPAIVHIN
  • AQTGSGKT
  • FVETKRRCD
  • GKTLAYL
  • FEKNFYVE
  • LAPTREL
  • HRIGRTAR
  • LELSANHNILQIVDVC
  • TPGRLID
  • ILIATDVA
  • LVLDEADR
  • MWSATWPK
  • QIRPDRQT
  • IHGDKSQ
  • SATWPKEV
  • APTRELA
  • GPQIRDL
  • GKTNLRR
  • IATPGRL
  • KSQPERD
  • PKFEKNFY
  • EANQAINPKL

Post-translational modifications for DDX17 Gene

  • Sumoylation significantly increases stability, it also promotes interaction with HDAC1.
  • Ubiquitination at Lys 42, Lys 50, Lys 53, Lys 190, Lys 373, Lys 389, Lys 436, Lys 449, and Lys 468
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX17 Gene

Antibody Products

Domains & Families for DDX17 Gene

Gene Families for DDX17 Gene

Graphical View of Domain Structure for InterPro Entry

Q92841

UniProtKB/Swiss-Prot:

DDX17_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
genes like me logo Genes that share domains with DDX17: view

Function for DDX17 Gene

Molecular function for DDX17 Gene

GENATLAS Biochemistry:
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.

Enzyme Numbers (IUBMB) for DDX17 Gene

Gene Ontology (GO) - Molecular Function for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003713 transcription coactivator activity IDA 17226766
GO:0003723 RNA binding TAS 8871553
GO:0003724 RNA helicase activity TAS 8871553
GO:0004004 ATP-dependent RNA helicase activity IBA --
genes like me logo Genes that share ontologies with DDX17: view
genes like me logo Genes that share phenotypes with DDX17: view

Animal Models for DDX17 Gene

MGI Knock Outs for DDX17:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX17 Gene

Localization for DDX17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX17 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX17 Gene COMPARTMENTS Subcellular localization image for DDX17 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DDX17: view

Pathways & Interactions for DDX17 Gene

SuperPathways for DDX17 Gene

SuperPathway Contained pathways
1 GPCR Pathway
genes like me logo Genes that share pathways with DDX17: view

Pathways by source for DDX17 Gene

1 Qiagen pathway for DDX17 Gene

Gene Ontology (GO) - Biological Process for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006396 RNA processing TAS 8871553
GO:0010501 RNA secondary structure unwinding IBA --
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IDA --
genes like me logo Genes that share ontologies with DDX17: view

No data available for SIGNOR curated interactions for DDX17 Gene

Drugs & Compounds for DDX17 Gene

(4) Drugs for DDX17 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DDX17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX17: view

Transcripts for DDX17 Gene

Unigene Clusters for DDX17 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 17:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6:
SP7:
SP8:

Relevant External Links for DDX17 Gene

GeneLoc Exon Structure for
DDX17
ECgene alternative splicing isoforms for
DDX17

Expression for DDX17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDX17 Gene

Protein differential expression in normal tissues from HIPED for DDX17 Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX17 Gene



Protein tissue co-expression partners for DDX17 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX17 Gene:

DDX17

SOURCE GeneReport for Unigene cluster for DDX17 Gene:

Hs.528305

mRNA Expression by UniProt/SwissProt for DDX17 Gene:

Q92841-DDX17_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DDX17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DDX17 Gene

Orthologs for DDX17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX17 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia DDX17 34 35
  • 95.3 (n)
oppossum
(Monodelphis domestica)
Mammalia DDX17 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX17 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDX17 34 35
  • 94.87 (n)
mouse
(Mus musculus)
Mammalia Ddx17 34 16 35
  • 90.15 (n)
chicken
(Gallus gallus)
Aves DDX17 34 35
  • 79.42 (n)
lizard
(Anolis carolinensis)
Reptilia DDX17 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx17 34
  • 73.96 (n)
zebrafish
(Danio rerio)
Actinopterygii DDX17 35
  • 73 (a)
OneToOne
LOC556764 34
  • 69.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10077 36 35
  • 67 (a)
Rm62 36 35
  • 65 (a)
CG10777 36 35
  • 59 (a)
CG14443 36
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005652 34
  • 61.95 (n)
worm
(Caenorhabditis elegans)
Secernentea F58E10.3 36 34
  • 59.56 (n)
ddx-17 35
  • 52 (a)
OneToMany
F58G11.2 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 35
  • 55 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6121 34
corn
(Zea mays)
Liliopsida Zm.5411 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1847 34
Species where no ortholog for DDX17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX17 Gene

ENSEMBL:
Gene Tree for DDX17 (if available)
TreeFam:
Gene Tree for DDX17 (if available)

Paralogs for DDX17 Gene

Paralogs for DDX17 Gene

genes like me logo Genes that share paralogs with DDX17: view

Variants for DDX17 Gene

Sequence variations from dbSNP and Humsavar for DDX17 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10427868 -- 38,487,218(+) AGCTA(C/G)GTTTg intron-variant
rs10427873 -- 38,487,338(+) CCTCA(A/G)CTAGG intron-variant
rs1043402 -- 38,483,683(+) ACAAC(A/G)AATTG downstream-variant-500B, utr-variant-3-prime
rs1062078 -- 38,489,291(-) CCAAA(A/T)ATAAA intron-variant
rs1062079 -- 38,489,191(-) TATTT(A/C)TATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX17 Gene

Variant ID Type Subtype PubMed ID
nsv834195 CNV loss 17160897

Variation tolerance for DDX17 Gene

Residual Variation Intolerance Score: 9.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX17 Gene

Disorders for DDX17 Gene

Relevant External Links for DDX17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX17

No disorders were found for DDX17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX17 Gene

Publications for DDX17 Gene

  1. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. (PMID: 17226766) Shin S. … Janknecht R. (J. Cell. Biochem. 2007) 2 3 4 22 64
  2. p72: a human nuclear DEAD box protein highly related to p68. (PMID: 8871553) Lamm G.M. … Lamond A.I. (Nucleic Acids Res. 1996) 2 3 4 22 64
  3. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. (PMID: 19995069) Mooney S.M. … Janknecht R. (Biochemistry 2010) 3 4 22 64
  4. The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. (PMID: 19718048) Wortham N.C. … Fuller-Pace F.V. (Oncogene 2009) 3 4 22 64
  5. p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. (PMID: 18334637) Chen G. … Gao G. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 4 22 64

Products for DDX17 Gene

Sources for DDX17 Gene

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