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Aliases for DDX17 Gene

Aliases for DDX17 Gene

  • DEAD-Box Helicase 17 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Helicase 17 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 17 (72kD) 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 17 2 3
  • RNA-Dependent Helicase P72 3 4
  • DEAD Box Protein P72 3 4
  • DEAD Box Protein 17 4
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • RH70 3
  • P72 3

External Ids for DDX17 Gene

Previous GeneCards Identifiers for DDX17 Gene

  • GC22M035496
  • GC22M037122
  • GC22M037124
  • GC22M037203
  • GC22M038879
  • GC22M021845

Summaries for DDX17 Gene

Entrez Gene Summary for DDX17 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family. This gene can encode multiple isoforms due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) start codon. [provided by RefSeq, Apr 2011]

GeneCards Summary for DDX17 Gene

DDX17 (DEAD-Box Helicase 17) is a Protein Coding gene. Among its related pathways are GPCR Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DDX53.

UniProtKB/Swiss-Prot for DDX17 Gene

  • RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.

Gene Wiki entry for DDX17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX17 Gene

Genomics for DDX17 Gene

Regulatory Elements for DDX17 Gene

Enhancers for DDX17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX17 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DDX17 gene promoter:

Genomic Location for DDX17 Gene

Chromosome:
22
Start:
38,483,438 bp from pter
End:
38,507,660 bp from pter
Size:
24,223 bases
Orientation:
Minus strand

Genomic View for DDX17 Gene

Genes around DDX17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX17 Gene

Proteins for DDX17 Gene

  • Protein details for DDX17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92841-DDX17_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX17
    Protein Accession:
    Q92841
    Secondary Accessions:
    • B1AHM0
    • Q69YT1
    • Q6ICD6

    Protein attributes for DDX17 Gene

    Size:
    729 amino acids
    Molecular mass:
    80272 Da
    Quaternary structure:
    • Interacts with ESR1. Interacts with NCOA1, NCOA2, NCOA3, TP53 and HDAC1. Self-associates. Interacts with DDX5. Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner. Interacts with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3 and EXOSC5 only in the presence of ZC3HAV1 in an RNA-independent manner.

    Alternative splice isoforms for DDX17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDX17 Gene

Proteomics data for DDX17 Gene at MOPED

Post-translational modifications for DDX17 Gene

  • Sumoylation significantly increases stability, it also promotes interaction with HDAC1.
  • Ubiquitination at Lys 42, Lys 50, Lys 53, Lys 190, Lys 373, Lys 389, Lys 436, Lys 449, and Lys 468
  • Modification sites at PhosphoSitePlus

Other Protein References for DDX17 Gene

Antibody Products

Domains & Families for DDX17 Gene

Gene Families for DDX17 Gene

Graphical View of Domain Structure for InterPro Entry

Q92841

UniProtKB/Swiss-Prot:

DDX17_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
genes like me logo Genes that share domains with DDX17: view

Function for DDX17 Gene

Molecular function for DDX17 Gene

GENATLAS Biochemistry:
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 17 (72kD)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.

Enzyme Numbers (IUBMB) for DDX17 Gene

Gene Ontology (GO) - Molecular Function for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 8871553
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
GO:0008186 RNA-dependent ATPase activity TAS 8871553
genes like me logo Genes that share ontologies with DDX17: view
genes like me logo Genes that share phenotypes with DDX17: view

Animal Models for DDX17 Gene

MGI Knock Outs for DDX17:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDX17 Gene

Localization for DDX17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX17 Gene

Nucleus. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX17 Gene COMPARTMENTS Subcellular localization image for DDX17 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for DDX17 Gene

Pathways & Interactions for DDX17 Gene

SuperPathways for DDX17 Gene

Superpath Contained pathways
1 GPCR Pathway
genes like me logo Genes that share pathways with DDX17: view

Pathways by source for DDX17 Gene

1 Qiagen pathway for DDX17 Gene

Gene Ontology (GO) - Biological Process for DDX17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:2001014 regulation of skeletal muscle cell differentiation IMP 17011493
genes like me logo Genes that share ontologies with DDX17: view

No data available for SIGNOR curated interactions for DDX17 Gene

Drugs & Compounds for DDX17 Gene

(2) Drugs for DDX17 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX17 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX17: view

Transcripts for DDX17 Gene

Unigene Clusters for DDX17 Gene

DEAD (Asp-Glu-Ala-Asp) box helicase 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX17 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c
SP1: - - - - - -
SP2: - - - - - -
SP3: - -
SP4: -
SP5: - - - - -
SP6:
SP7:
SP8:

Relevant External Links for DDX17 Gene

GeneLoc Exon Structure for
DDX17
ECgene alternative splicing isoforms for
DDX17

Expression for DDX17 Gene

mRNA expression in normal human tissues for DDX17 Gene

Protein differential expression in normal tissues from HIPED for DDX17 Gene

This gene is overexpressed in Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX17 Gene



SOURCE GeneReport for Unigene cluster for DDX17 Gene Hs.528305

mRNA Expression by UniProt/SwissProt for DDX17 Gene

Q92841-DDX17_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DDX17: view

Protein tissue co-expression partners for DDX17 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DDX17 Gene

Orthologs for DDX17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX17 35
  • 94.87 (n)
  • 99.69 (a)
DDX17 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX17 35
  • 95.3 (n)
  • 99.3 (a)
DDX17 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx17 35
  • 90.15 (n)
  • 98.77 (a)
Ddx17 16
Ddx17 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX17 35
  • 99.79 (n)
  • 100 (a)
DDX17 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDX17 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX17 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX17 35
  • 79.42 (n)
  • 90.64 (a)
DDX17 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX17 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx17 35
  • 73.96 (n)
  • 85.36 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC556764 35
  • 69.93 (n)
  • 79.07 (a)
DDX17 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10077 37
  • 67 (a)
CG10777 37
  • 59 (a)
CG14443 37
  • 32 (a)
Rm62 37
  • 65 (a)
CG10077 36
  • 43 (a)
ManyToMany
CG10777 36
  • 37 (a)
ManyToMany
Rm62 36
  • 45 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005652 35
  • 61.95 (n)
  • 67.58 (a)
worm
(Caenorhabditis elegans)
Secernentea F58E10.3 37
  • 60 (a)
F58G11.2 37
  • 31 (a)
F58E10.3 35
  • 59.56 (n)
  • 60.77 (a)
ddx-17 36
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBP2 36
  • 55 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.6121 35
corn
(Zea mays)
Liliopsida Zm.5411 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1847 35
Species with no ortholog for DDX17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX17 Gene

ENSEMBL:
Gene Tree for DDX17 (if available)
TreeFam:
Gene Tree for DDX17 (if available)

Paralogs for DDX17 Gene

Paralogs for DDX17 Gene

genes like me logo Genes that share paralogs with DDX17: view

Variants for DDX17 Gene

Sequence variations from dbSNP and Humsavar for DDX17 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs13996 -- 38,486,022(-) CCTCC(A/G)GGAGC reference, synonymous-codon
rs15530 -- 38,488,261(+) AGAAA(A/C)AAAAA intron-variant
rs86796 -- 38,485,449(+) GGGCA(A/C)TCCCT utr-variant-3-prime
rs2267390 -- 38,493,652(+) ATGAA(C/T)ATTCA intron-variant
rs7291775 -- 38,507,310(+) cgcag(A/C/T)gagcc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DDX17 Gene

Variant ID Type Subtype PubMed ID
nsv834195 CNV Loss 17160897
nsv915066 CNV Loss 21882294

Variation tolerance for DDX17 Gene

Residual Variation Intolerance Score: 9.76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDX17 Gene

Disorders for DDX17 Gene

Relevant External Links for DDX17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX17

No disorders were found for DDX17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX17 Gene

Publications for DDX17 Gene

  1. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. (PMID: 17226766) Shin S. … Janknecht R. (J. Cell. Biochem. 2007) 2 3 4 23 67
  2. p72: a human nuclear DEAD box protein highly related to p68. (PMID: 8871553) Lamm G.M. … Lamond A.I. (Nucleic Acids Res. 1996) 2 3 23
  3. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. (PMID: 19995069) Mooney S.M. … Janknecht R. (Biochemistry 2010) 3 23
  4. The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer. (PMID: 19718048) Wortham N.C. … Fuller-Pace F.V. (Oncogene 2009) 3 23
  5. p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein. (PMID: 18334637) Chen G. … Gao G. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23

Products for DDX17 Gene

Sources for DDX17 Gene

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