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Aliases for DDX12P Gene

Aliases for DDX12P Gene

  • DEAD/H-Box Helicase 12, Pseudogene 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12, Pseudogene 2 3 5
  • CHL1-Related Protein 2 3 4
  • DEAD/H Box Protein 12 3 4
  • HCHLR2 3 4
  • DDX12 3 4
  • CHLR2 3 4
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12 (CHL1-Like Helicase Homolog, S. Cerevisiae) 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12 (S.Cerevisiae CHL1-Like Helicase) 2
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12 2
  • CHL1-Like Helicase Homolog 2 (S. Cerevisiae) 2
  • Probable ATP-Dependent RNA Helicase DDX12 3
  • CHL1-Like Helicase Homolog 2 3
  • DEAD/H Box-12 3
  • EC 3.6.1.23 63
  • EC 3.6.4.13 4
  • EC 3.6.1.7 63
  • EC 3.6.1 63

External Ids for DDX12P Gene

Previous HGNC Symbols for DDX12P Gene

  • DDX12

Previous GeneCards Identifiers for DDX12P Gene

  • GC12M009571
  • GC12M009572
  • GC12M009720
  • GC12M010042
  • GC12M010237
  • GC12M010476

Summaries for DDX12P Gene

GeneCards Summary for DDX12P Gene

DDX12P (DEAD/H-Box Helicase 12, Pseudogene) is a Pseudogene. GO annotations related to this gene include RNA binding and ATP-dependent DNA helicase activity.

UniProtKB/Swiss-Prot for DDX12P Gene

  • DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX12P Gene

Genomics for DDX12P Gene

Regulatory Elements for DDX12P Gene

Enhancers for DDX12P Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDX12P on UCSC Golden Path with GeneCards custom track

Promoters for DDX12P Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDX12P on UCSC Golden Path with GeneCards custom track

Genomic Location for DDX12P Gene

Chromosome:
12
Start:
9,417,691 bp from pter
End:
9,448,229 bp from pter
Size:
30,539 bases
Orientation:
Minus strand

Genomic View for DDX12P Gene

Genes around DDX12P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX12P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX12P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX12P Gene

Proteins for DDX12P Gene

  • Protein details for DDX12P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92771-DDX12_HUMAN
    Recommended name:
    Putative ATP-dependent RNA helicase DDX12
    Protein Accession:
    Q92771

    Protein attributes for DDX12P Gene

    Size:
    950 amino acids
    Molecular mass:
    106006 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDX12P Gene

Proteomics data for DDX12P Gene at MOPED

Post-translational modifications for DDX12P Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DDX12P Gene

Gene Families for DDX12P Gene

Suggested Antigen Peptide Sequences for DDX12P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92771

UniProtKB/Swiss-Prot:

DDX12_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
Domain:
  • Contains 1 helicase ATP-binding domain.
Family:
  • Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.
genes like me logo Genes that share domains with DDX12P: view

Function for DDX12P Gene

Molecular function for DDX12P Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity).

Enzyme Numbers (IUBMB) for DDX12P Gene

Gene Ontology (GO) - Molecular Function for DDX12P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004003 ATP-dependent DNA helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX12P: view

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DDX12P Gene

Localization for DDX12P Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX12P Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DDX12P Gene

Pathways & Interactions for DDX12P Gene

SuperPathways for DDX12P Gene

No Data Available

Interacting Proteins for DDX12P Gene

Gene Ontology (GO) - Biological Process for DDX12P Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process IEA --
genes like me logo Genes that share ontologies with DDX12P: view

No data available for Pathways by source and SIGNOR curated interactions for DDX12P Gene

Drugs & Compounds for DDX12P Gene

(1) Drugs for DDX12P Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX12P Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX12P: view

Transcripts for DDX12P Gene

mRNA/cDNA for DDX12P Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDX12P Gene

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX12P Gene

No ASD Table

Relevant External Links for DDX12P Gene

GeneLoc Exon Structure for
DDX12P
ECgene alternative splicing isoforms for
DDX12P

Expression for DDX12P Gene

mRNA expression in normal human tissues for DDX12P Gene

SOURCE GeneReport for Unigene cluster for DDX12P Gene Hs.504688

mRNA Expression by UniProt/SwissProt for DDX12P Gene

Q92771-DDX12_HUMAN
Tissue specificity: Only expressed in proliferating tissues.
genes like me logo Genes that share expression patterns with DDX12P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DDX12P Gene

Orthologs for DDX12P Gene

Evolution for DDX12P Gene

ENSEMBL:
Gene Tree for DDX12P (if available)
TreeFam:
Gene Tree for DDX12P (if available)

No data available for Orthologs for DDX12P Gene

Paralogs for DDX12P Gene

(3) SIMAP similar genes for DDX12P Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDX12P: view

No data available for Paralogs for DDX12P Gene

Variants for DDX12P Gene

Sequence variations from dbSNP and Humsavar for DDX12P Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2075326 -- 9,417,565(-) GGCCT(C/G)AAGCC downstream-variant-500B
rs7134199 -- 9,419,790(+) GGCCA(A/G)CCTAA intron-variant
rs7296629 -- 9,424,714(+) GGTCC(A/C)CAGTT intron-variant
rs7298124 -- 9,421,446(+) CCCCG(A/C/T)TGCAG nc-transcript-variant
rs12816109 -- 9,419,951(+) TCACG(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX12P Gene

Variant ID Type Subtype PubMed ID
dgv466e1 CNV Complex 17122850
nsv7228 OTHER Inversion 18451855
nsv898744 CNV Loss 21882294
nsv898745 CNV Gain 21882294
nsv508665 CNV Loss 20534489
nsv509454 CNV Insertion 20534489
esv2568009 CNV Loss 19546169
dgv467e1 CNV Complex 17122850
nsv428271 CNV Gain 18775914
dgv468e1 CNV Complex 17122850
nsv8907 CNV Gain 18304495
dgv1368n71 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for DDX12P Gene

Disorders for DDX12P Gene

Relevant External Links for DDX12P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX12P

No disorders were found for DDX12P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX12P Gene

Publications for DDX12P Gene

  1. Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. (PMID: 9013641) Amann J. … Lahti J.M. (J. Biol. Chem. 1997) 3 4 67
  2. Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. (PMID: 17611414) Inoue A. … Lahti J.M. (Cell Cycle 2007) 23
  3. Lineage-specific gene duplication and loss in human and great ape evolution. (PMID: 15252450) Fortna A. … Sikela J.M. (PLoS Biol. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA. (PMID: 8833153) Amann J. … Lahti J.M. (Genomics 1996) 3

Products for DDX12P Gene

Sources for DDX12P Gene

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