DDX12P Gene
pseudogene GIFtS: 38
GCID: GC12M010042
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DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 (S.cerevisiae...)
(Previous symbol: DDX12)
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Aliases
for DDX12P gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 4
| Aliases |
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| DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12, Pseudogene1 2 | | CHL1-Related Protein 23 | | CHLR21 2 3 5 | | DEAD/H Box Protein 123 | | DDX121 2 3 5 | | HCHLR21 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 121 | | EC 3.6.18 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 12 (S.Cerevisiae CHL1-LikeHelicase)1 | | EC 3.6.1.238 | | EC 3.6.4.133 | | EC 3.6.1.78 |
| External Ids: | HGNC: 27371 | Entrez Gene: 4400812 | Ensembl: ENSG000002148267 | OMIM: 6011515 | UniProtKB: Q927713 |
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Export aliases for DDX12P gene to outside databasesPrevious GC identifers: GC12M009571 GC12M009572 GC12M009720
Summaries
for DDX12P gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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UniProtKB/Swiss-Prot: DDX12_HUMAN, Q92771Function: DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation(By similarity)
fRNAdb sequence ontology for DDX12P:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.
View fRNAdb secondary structures for DDX12P |
Genomic Views
for DDX12P gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DDX12P
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDX12P
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX12P |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31DDX12P Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M010042: view genomic region
(about GC identifiers)
Start:
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9,570,287 bp from pter |
End:
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9,600,825 bp from pter |
Size:
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30,539 bases |
Orientation:
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minus strand |
ORGUL member locations:
Legend (see complete legend)
- n346171
- n409235
- n346282
- n346427
9568581 9584695 9600808 chr12
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Proteins
for DDX12P gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDX12_HUMAN, Q92771 (See
protein sequence)Recommended Name: Putative ATP-dependent RNA helicase DDX12 Size: 950 amino acids; 106006 Da
Subcellular location: Nucleus (By similarity)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for DDX12P: NX_Q92771
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92771
4/29 DME Specific Peptides for DDX12P (Q92771) (see all 29)
DDX12P Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005634 | nucleus |
IEA | -- |
DDX12P for ontologies About GeneDecksing
DDX12P Antibody Products:
Assay Products for DDX12P: |
Protein
Domains /
Families
for DDX12P gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDX12P for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q92771ProtoNet protein and cluster: Q92771 1 Blocks protein family: IPB006555 Helicase c2
UniProtKB/Swiss-Prot: DDX12_HUMAN, Q92771Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamilySimilarity: Contains 1 helicase ATP-binding domain |
Function
for DDX12P gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: DDX12_HUMAN, Q92771Function: DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation(By similarity)Catalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131 EC 3.6.1.72 EC 3.6.1.232
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX12P |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
DDX12P for ontologies About GeneDecksing
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Pathways & Interactions
for DDX12P gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX12P
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007049 | cell cycle |
IEA | -- |
DDX12P for ontologies About GeneDecksing
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Drugs & Compounds
for DDX12P gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DDX12P
Search CenterWatch for drugs/clinical trials and news about DDX12P 
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Transcripts
for DDX12P gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
| 1 fRNAdb Secondary structure:
REFSEQ mRNAs for DDX12P gene: NM_004400.1 Unigene Cluster for DDX12P: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene Hs.504688 [show with all ESTs]Unigene Representative Sequence: BC0654943 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432996 ENST00000290818(uc001qvx.4 uc001qvy.1 uc021qut.1 uc009zgq.1)
ENST00000440299
Additional cDNA sequence: BC035635.1 BC065494.1 DQ786301.1 16 DOTS entries: DT.100729357 DT.91823285 DT.100645301 DT.121644168 DT.92011811 DT.102831417 DT.102831413 DT.102821093 DT.121214799 DT.121214835 DT.121214840 DT.121639716 DT.85104528 DT.91814925 DT.95259742 DT.97806073 24/29 AceView cDNA sequences (see all 29): BC065494 BV196358 BX504138 BQ712505 AI961123 BC035635 BU931905 BM805072 AA252449 CF137089 BM756871 BM756886 BE827249 CD632668 BM771525 BI910121 CD632667 BX444193 U33834 BU856039 BU859408 CF143707 AA189075 AL135410
GeneLoc Exon Structure
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Expression
for DDX12P gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDX12P expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGACCTTTG
About this image
See DDX12P Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDX12P
SOURCE GeneReport for Unigene cluster: Hs.504688
UniProtKB/Swiss-Prot: DDX12_HUMAN, Q92771Tissue specificity: Only expressed in proliferating tissues
SABiosciences Custom PCR Arrays for DDX12P
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX12P
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DDX12P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX12P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX12P | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX12P |
Orthologs
for DDX12P gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for DDX12P (if available)
TreeFam Gene Tree for DDX12P (if available) |
Paralogs
for DDX12P gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DDX12P gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DDX12P (9570287 - 9600825 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DDX12P: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for DDX12P gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 DDX12P for disorders About MalaCards
DDX12P for disorders About GeneDecksing
OMIM gene information: 601151 601150
Export disorders for DDX12P gene to outside databases
|
Publications
for DDX12P gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DDX12P gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with DDX12P) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. (PubMed id 9013641)1, 2 Amann J.... Lahti J.M. (1997)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- Lineage-specific gene duplication and loss in human and great ape evolution. (PubMed id 15252450)1 Fortna A....Sikela J.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Localization of chi1-related helicase genes to human chromosome regions 12p11 and 12p13: similarity between parts of these genes and conserved human telomeric-associated DNA. (PubMed id 8833153)1 Amann J....Lahti J.M. (1996)
- Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. (PubMed id 17611414)9 Inoue A....Lahti J.M. (2007)
- (PubMed id 15103394)10
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External Searches for DDX12P gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DDX12P gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDX12P gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDX12P gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DDX12P | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DDX12P gene:
Search GeneIP for patents involving DDX12P
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDX12P gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DDX12P | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX12P | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX12P | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DDX12P | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX12P | | Browse OriGene Myc/DDK tagged cDNA clones in CMV expression vector | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DDX12P | | OriGene Custom Protein Services for DDX12P | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX12P | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX12P | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX12P | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX12P | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX12P | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX12P |
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 |  |  |  | |
| | | | Search Tocris compounds for DDX12P |
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 | | | DDX12P Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX12P |
|  |  |  | | | | ThermoFisher Antibodies for DDX12P |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DDX12P |
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