DDX11L8 Gene
pseudogene GIFtS: 19
GCID: GC12M000095
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DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 like 8(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 like 8...)
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Aliases
for DDX11L8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
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| DEAD/H (Asp-Glu-Ala-Asp/His) Box Helicase 11 Like 81 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 Like 81 2 | | EC 3.6.4.133 | | DEAD/H Box Protein 11-Like 83 |
Export aliases for DDX11L8 gene to outside databasesPrevious GC identifers: GC00U928076 GC12P000091 |
Summaries
for DDX11L8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: D11L8_HUMAN, A8MPP1Function: Putative DNA helicase (By similarity)
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Genomic Views
for DDX11L8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DDX11L8
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDX11L8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX11L8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Ensembl cytogenetic band: 12p13.33 HGNC cytogenetic band: 12p13.33DDX11L8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M000095: view genomic region
(about GC identifiers)
Start:
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92,146 bp from pter |
End:
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93,430 bp from pter |
Size:
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1,285 bases |
Orientation:
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minus strand |
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Proteins
for DDX11L8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: D11L8_HUMAN, A8MPP1 (See
protein sequence)Recommended Name: Putative ATP-dependent RNA helicase DDX11-like protein 8 Size: 907 amino acids; 101811 Da
Subcellular location: Nucleus, nucleolus (By similarity)
Caution: Defined as a pseudogene by HGNC. However, proteomics data suggest the existence of the proteinExplore the universe of human proteins at neXtProt for DDX11L8: NX_A8MPP1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MPP1
DDX11L8 Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
DDX11L8 Antibody Products:
Assay Products for DDX11L8: |
Protein
Domains /
Families
for DDX11L8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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DDX11L8 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry A8MPP1ProtoNet protein and cluster: A8MPP1 UniProtKB/Swiss-Prot: D11L8_HUMAN, A8MPP1Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamilySimilarity: Contains 1 helicase ATP-binding domain |
Function
for DDX11L8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: D11L8_HUMAN, A8MPP1Function: Putative DNA helicase (By similarity)Catalytic activity: ATP + H(2)O = ADP + phosphateEnzyme Number (IUBMB): EC 3.6.4.131
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Pathways & Interactions
for DDX11L8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX11L8
5/76 Interacting proteins for DDX11L8 (A8MPP13) via UniProtKB, MINT, STRING, and/or I2D (see all 76)About this table
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Drugs & Compounds
for DDX11L8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DDX11L8
Search CenterWatch for drugs/clinical trials and news about DDX11L8 
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Transcripts
for DDX11L8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000535849
GeneLoc Exon Structure
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Expression
for DDX11L8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDX11L8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DDX11L8 Protein Expression from SPIRE MOPED and PaxDB SABiosciences Custom PCR Arrays for DDX11L8
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DDX11L8 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX11L8 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX11L8 |
Orthologs
for DDX11L8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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--
ENSEMBL Gene Tree for DDX11L8 (if available)
TreeFam Gene Tree for DDX11L8 (if available) |
Paralogs
for DDX11L8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for DDX11L8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for DDX11L8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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DDX11L8 for disorders About GeneDecksing
2  diseases for DDX11L8: About MalaCardscornelia de lange syndrome roberts syndrome
3 diseases from the University of Copenhagen DISEASES database for DDX11L8:Baller-Gerold syndrome Roberts syndrome Fanconi's anemia Export disorders for DDX11L8 gene to outside databases
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Publications
for DDX11L8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for DDX11L8 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DDX11L8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DDX11L: a novel transcript family emerging from human subtelomeric regions. (PubMed id 19476624)1, 3 Costa V.... Ciccodicola A. (2009)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
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External Searches for DDX11L8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DDX11L8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing DDX11L8 gene
(According to HUGE)
About This Section
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Specialized Databases showing DDX11L8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for DDX11L8 gene:
Search GeneIP for patents involving DDX11L8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DDX11L8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX11L8 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX11L8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX11L8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX11L8 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX11L8 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX11L8 |
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| | | | Search Tocris compounds for DDX11L8 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for DDX11L8 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DDX11L8 |
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