DDX11 Gene
protein-coding GIFtS: 61
GCID: GC12P031226
|
|
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (S.cerevisiae...)
| |
Aliases
for DDX11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DEAD/H (Asp-Glu-Ala-Asp/His) Box Helicase 111 2 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 111 | | CHLR11 2 3 5 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (S.Cerevisiae CHL1-LikeHelicase)1 | | KRG21 2 3 5 | | CHL1-Like Helicase Homolog2 | | CHL11 2 3 | | CHL1-Related Helicase Gene-12 | | WABS1 2 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (CHL1-Like Helicase Homolog, S.Cerevisiae)2 | | Keratinocyte Growth Factor-Regulated Gene 2 Protein2 3 | | Probable ATP-Dependent RNA Helicase DDX112 | | KRG-22 3 | | EC 3.6.4.133 | | CHL1-Related Protein 12 3 | | EC 3.6.18 | | DEAD/H Box Protein 112 3 | | EC 3.6.1.238 | | HCHLR11 | | EC 3.6.1.78 | | ChlR11 | | |
Export aliases for DDX11 gene to outside databasesPrevious GC identifers: GC12P031609 GC12P031250 GC12P031127 GC12P031118 GC12P030992 |
Summaries
for DDX11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DDX11:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alteration of RNA secondary structure such as translationinitiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distributionpatterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellulargrowth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNAhelicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosometransmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encodingdistinct isoforms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DDX11_HUMAN, Q96FC9Function: DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. Thishelicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent,dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplexstructures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, whichcan be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complexactivities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Requiredfor recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genomemaintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and theprevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- anddouble-stranded DNA
Gene Wiki entry for DDX11
|
Genomic Views
for DDX11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDX11 gene promoter:
c-Fos Bach1 AP-1 JunB Fra-1 FosB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDX11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p11 Ensembl cytogenetic band: 12p11.21 HGNC cytogenetic band: 12p11.21DDX11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P031226: view genomic region
(about GC identifiers)
Start:
|
31,226,779 bp from pter |
End:
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31,257,725 bp from pter |
Size:
|
30,947 bases |
Orientation:
|
plus strand |
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Proteins
for DDX11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDX11_HUMAN, Q96FC9 (See
protein sequence)Recommended Name: Probable ATP-dependent RNA helicase DDX11 Size: 970 amino acids; 108313 Da
Cofactor: Binds 1 4Fe-4S cluster (By similarity)
Subunit: Interacts with the CTF18-RFC complex, PCNA and FEN1. Forms a complex with RAD21, SMC1 and SMC3. Interacts withbovine papillomavirus type 1 regulatory protein E2
Subcellular location: Nucleus. Nucleus, nucleolus. Note=During the early stages of mitosis, localizes to condensedchromatin and is released from the chromatin with progression to metaphase. Also localizes to the spindle polesthroughout mitosis and at the midbody at later stages of mitosis (metaphase to telophase). Co-localizes with bovinepapillomavirus type 1 regulatory protein E2 at early stages of mitosis
Sequence caution: Sequence=CAA67895.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAA67895.1; Type=Frameshift; Positions=644, 648;
Secondary accessions: Q13333 Q86VQ4 Q86W62 Q92498 Q92770 Q92998 Q92999Alternative splicing: 5 isoforms: Q96FC9-1 Q96FC9-2 Q96FC9-3 Q96FC9-4 Q96FC9-5 Explore the universe of human proteins at neXtProt for DDX11: NX_Q96FC9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96FC9
4/27 DME Specific Peptides for DDX11 (Q96FC9) (see all 27)
DDX11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001244073.1 NP_001244074.1 NP_004390.3 NP_085911.2 NP_689651.1
ENSEMBL proteins: ENSP00000443426 ENSP00000442466 ENSP00000228264 ENSP00000407646 ENSP00000406799 ENSP00000443578 ENSP00000445568 ENSP00000406457 ENSP00000440402 ENSP00000309965 ENSP00000439298 ENSP00000441425 ENSP00000440171 ENSP00000445219 ENSP00000443750 ENSP00000441015 ENSP00000384703 ENSP00000251758 Reactome Protein details: Q96FC9
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
DDX11 for ontologies About GeneDecksing
DDX11 Antibody Products:
Assay Products for DDX11: |
Protein
Domains /
Families
for DDX11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDX11 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96FC9ProtoNet protein and cluster: Q96FC9 1 Blocks protein family: IPB002464 ATP-dependent helicase
UniProtKB/Swiss-Prot: DDX11_HUMAN, Q96FC9Similarity: Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamilySimilarity: Contains 1 helicase ATP-binding domain |
Function
for DDX11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DDX11_HUMAN, Q96FC9Function: DNA helicase involved in cellular proliferation. Possesses DNA-dependent ATPase and helicase activities. Thishelicase translocates on single-stranded DNA in the 5' to 3' direction in the presence of ATP and, to a lesser extent,dATP. Its unwinding activity requires a 5'-single-stranded region for helicase loading, since flush-ended duplexstructures do not support unwinding. The helicase activity is capable of displacing duplex regions up to 100 bp, whichcan be extended to 500 bp by RPA or the cohesion establishment factor, the Ctf18-RFC (replication factor C) complexactivities. Stimulates the flap endonuclease activity of FEN1. Required for normal sister chromatid cohesion. Requiredfor recruitment of bovine papillomavirus type 1 regulatory protein E2 to mitotic chrmosomes and for viral genomemaintenance. Required for maintaining the chromosome segregation and is essential for embryonic development and theprevention of aneuploidy. May function during either S, G2, or M phase of the cell cycle. Binds to both single- anddouble-stranded DNACatalytic activity: ATP + H(2)O = ADP + phosphateEnzyme regulation: Helicase shows maximal activity with magnesium ions at low concentrations (0.5-1mM) whereas ismarkedly inhibited at higher levels (5 mM and above). Stimulated by 25-50 mM potassium acetate, stimulated to a lesserextent by 25 mM of ammonium acetate, and markedly inhibited by sodium acetate. The ATPase activity is stimulated byhigh salt levels (up to a 0.1 M) and potassium salts (glutamate, chloride or acetate) are more effective than thecorresponding sodium salts Genatlas biochemistry entry for DDX11:DEAD/H box protein 11,yeast Chl1 related-helicase gene 1,putative regulator of chromosome segregation and transmission
Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131 EC 3.6.1.72 EC 3.6.1.232
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX11 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX11 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): DDX11 (NM_030653) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX11 |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
DDX11 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ddx11tm1Jiml for DDX11
6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ddx11):
DDX11 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DDX11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of Chaperone Genes by XBP1(S) | | | 2 | Expression of DDX11 | | | 3 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for DDX11
DDX11 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/14 Interacting proteins for DDX11 (Q96FC92, 3 ENSP000003847034) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
DDX11 for ontologies About GeneDecksing
|
Drugs & Compounds
for DDX11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DDX11 for compounds About GeneDecksing
 Browse Tocris compounds for DDX11
1 Novoseek chemical compound relationship for DDX11 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nitrate |
41.5 |
8 |
8453665 (3), 11912226 (2), 11487691 (1) |
Search CenterWatch for drugs/clinical trials and news about DDX11
|
Transcripts
for DDX11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DDX11 gene (6 alternative transcripts): NM_001257144.1 NM_001257145.1 NM_004399.2 NM_030653.3 NM_152438.1 NM_030655.2 Unigene Cluster for DDX11: DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 Hs.443960 [show with all ESTs]Unigene Representative Sequence: U7596818/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32): ENST00000542838(uc010sjx.1) ENST00000542129 ENST00000228264(uc001rjw.1 uc009zjn.1 uc009zjo.1)
ENST00000438391 ENST00000435753 ENST00000540935 ENST00000539049 ENST00000536265
ENST00000415475 ENST00000545668 ENST00000350437 ENST00000535158(uc010sjw.1)
ENST00000543756 ENST00000542244 ENST00000535317 ENST00000544652 ENST00000538345
ENST00000542242
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX11 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX11 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): DDX11 (NM_030653) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX11 |
Additional cDNA sequence: AK297607.1 AK303139.1 BC001591.2 BC011264.1 BC012834.2 BC050069.1 BC050522.1 BC111733.1 BC148224.1 DQ786287.1 U33833.1 U75967.1 U75968.1 U75969.1 X99583.1 24/25 DOTS entries (see all 25): DT.85104528 DT.91681776 DT.91750700 DT.91750693 DT.100645303 DT.121209508 DT.121209422 DT.100645301 DT.91749731 DT.92415338 DT.121209501 DT.75124405 DT.91750701 DT.121209504 DT.91871465 DT.92011811 DT.95138041 DT.95329414 DT.97817818 DT.100729357 DT.100846782 DT.121639716 DT.91750699 DT.91823285 24/169 AceView cDNA sequences (see all 169): BU151363 BM795044 BC047317 CR617012 BX352916 BU859051 AA505529 BG479641 BU728275 BQ921461 BC050069 BC001591 CR590809 BC050522 BQ049975 CA418439 BC011264 CA446265 BV202904 NM_030653 BQ053959 BX331255 BE138729 AA653212
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DDX11 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DDX11
|
Expression
for DDX11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDX11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTATAGAGA
About this image
See DDX11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDX11
SOURCE GeneReport for Unigene cluster: Hs.443960
UniProtKB/Swiss-Prot: DDX11_HUMAN, Q96FC9Tissue specificity: Highly expressed in spleen, B-cells, thymus, testis, ovary, small intestine, and pancreas. Very lowexpression seen in the brain. Expressed in dividing cells and/or cells undergoing high levels of recombination. Noexpression is seen in cells signaled to terminally differentiate. Expressed in keratinocyte growth factor-stimulatedcells but not in serum, EGF and IL1-beta-treated keratinocytes
SABiosciences Expression via Pathway-Focused PCR Array including DDX11:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX11 |
Orthologs
for DDX11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DDX11 gene from 8/30 species (see all 30) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DDX111 |
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 |
71.51(n)
72.52(a) |
|
418144 XM_416375.3 XP_416375.3 |
lizard
(Anolis carolinensis) |
Reptilia |
DDX116 |
-- |
60(a) |
1 ↔ 1 |
5(11291524-11321675) |
zebrafish
(Danio rerio) |
Actinopterygii |
ddx111 |
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 |
63.97(n)
62.62(a) |
|
492353 NM_001007319.1 NP_001007320.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
EG:33C11.23
CG114031 |
nucleotide-excision repair helicase3
CG114031 |
37(a)3
52.06(n)1
43.83(a)1 |
|
310721 NM_130542.31 NP_569898.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
M03C11.23
chl-11 |
CHL1 protein3
Protein CHL-11 |
31(a)3
46.66(n)1
38.5(a)1 |
|
III(10470951-10476893)3
1764571 NM_066894.31 NP_499295.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
CHL11 |
Chl1p |
45.09(n)
37.5(a) |
|
856099 NP_015317.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G798901 |
chromosome transmission fidelity protein 1 |
49.47(n)
43.07(a) |
|
844328 NM_106638.1 NP_178107.1 |
rice
(Oryza sativa) |
Liliopsida |
-- |
helicase, putative, expressed |
32(a) |
1 ↔ 1 |
5(7367109-7374425) |
ENSEMBL Gene Tree for DDX11 (if available)
TreeFam Gene Tree for DDX11 (if available) |
Paralogs
for DDX11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DDX11 gene
- RTEL12 BRIP12 RTEL1-TNFRSF6B2
6 SIMAP similar genes for DDX11 using alignment to 13 protein entries: DDX11_HUMAN (see all proteins):CHLR1 DDX11L8 DDX12P DDX11L2 DDX11L3 DDX11L9
DDX11 for paralogs About GeneDecksing
5/10 Pseudogenes.org Pseudogenes for DDX11 (see all 10)
PGOHUM00000239287 PGOHUM00000258616 PGOHUM00000258656 PGOHUM00000262875 PGOHUM00000246952
|
Genomic Variants
for DDX11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DDX11 (31226779 - 31257725 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 26 variations for DDX11
15/26 CNVs (see all 26): 2976 5282 8715 8712 71485 86296 3884 5283 34567 5284 5291 8717 5286 5281 34528
Human Gene Mutation Database (HGMD): DDX11
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX11 |
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Disorders
/ Diseases
for DDX11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DDX11 for disorders About GeneDecksing
OMIM gene information: 601150
OMIM disorders: 613398
UniProtKB/Swiss-Prot: DDX11_HUMAN, Q96FC9
Defects in DDX11 are the cause of Warsaw breakage syndrome (WBRS) [MIM:613398]. It is a syndrome characterizedby severe microcephaly, pre- and postnatal growth retardation, facial dysmorphism and abnormal skin pigmentation.Additional features include high arched palate, coloboma of the right optic disk, deafness, ventricular septal defect,toes and fingers abnormalities. At cellular level, drug-induced chromosomal breakage, a feature of Fanconi anemia, andsister chromatid cohesion defects, a feature of Roberts syndrome, coexist
12  diseases for DDX11: About MalaCardscornelia de lange syndrome warsaw breakage syndrome roberts syndrome esophageal squamous cell carcinoma
squamous cell carcinoma fanconi's anemia coloboma microcephaly
anemia esophagitis carcinoma malaria
3 diseases from the University of Copenhagen DISEASES database for DDX11:Baller-Gerold syndrome Roberts syndrome Fanconi's anemia Export disorders for DDX11 gene to outside databases
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Publications
for DDX11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for DDX11 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with DDX11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. (PubMed id 18499658)1, 2, 9 Farina A....Hurwitz J. (2008)
- Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. (PubMed id 10648783)1, 2, 9 Hirota Y. and Lahti J.M. (2000)
- Characterization of putative human homologues of the yeast chromosome transmission fidelity gene, CHL1. (PubMed id 9013641)1, 2, 9 Amann J.... Lahti J.M. (1997)
- The human homologue of the yeast CHL1 gene is a novel keratinocyte growth factor regulated gene. (PubMed id 8798685)1, 2, 9 Frank S. and Werner S. (1996)
- The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. (PubMed id 17105772)1, 2 Parish J.L....Androphy E.J. (2006)
- ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance. (PubMed id 17189189)1, 2 Parish J.L....Androphy E.J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. (PubMed id 20137776)2, 9 van der Lelij P....de Winter J.P. (2010)
- Identification and biochemical characterization of a novel mutation in DDX11 causing warsaw breakage syndrome. (PubMed id 23033317)2 Capo-Chichi J.M.... Kibar Z. (2013)
- Biochemical characterization of Warsaw breakage syndro me helicase. (PubMed id 22102414)1 Wu Y....Brosh R.M. (2012)
|
External Searches for DDX11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing DDX11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDX11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDX11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for DDX11 gene:
Search GeneIP for patents involving DDX11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDX11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DDX11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX11 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DDX11 | | OriGene 3'-UTR Clone for DDX11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DDX11 | | OriGene Custom Protein Services for DDX11 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX11 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX11 |
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