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Aliases & Descriptions for DDX10
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 3.6.1.- 3 | | HRH-J8 1, 2 |
| | | Descriptions |
|---|
| DDX10-NUP98 fusion protein type 2 2 | | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2 | | DEAD box protein 10 3 | | DEAD box-10 2 | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase) 1, 2 |
|
| | Search outside databases for aliases for DDX10 genePrevious GC identifers: GC11P110792 GC11P109988 GC11P108569 GC11P108073 |
Summaries for DDX10(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for DDX10: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq] UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206Function: Putative ATP-dependent RNA helicaseGene Wiki entry for DDX10 |
Genomic Location for DDX10
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the DDX10 gene 
Entrez Gene cytogenetic band: 11q22-q23 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22-q23DDX10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P108041:
(about GC identifiers)
Start:
|
108,041,014 bp from pter |
End:
|
108,316,866 bp from pter |
Size:
|
275,853 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033899.7
| Proteins for DDX10
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206 (See
protein sequence)Recommended Name: Probable ATP-dependent RNA helicase DDX10 Size: 875 amino acids; 100888 Da
PDB structures from and Proteopedia :2PL3 (3D)
 
Secondary accessions: Q5BJD8Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004389.2
ENSEMBL proteins: ENSP00000314348
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for DDX10: Assays for DDX10: | Protein
Domains/ Families for DDX10(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q13206
ProtoNet protein and cluster: Q13206 1 Blocks protein family: IPB000629 ATP-dependent helicase
UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206Domain: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysisSimilarity: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamilySimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domain | Gene Function for DDX10
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004398
Applied Biosystems Silencer® siRNAs for DDX10
Sigma-Aldrich siRNA for DDX10  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004398                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004398                                  untagged cDNA clone in CMV expression vector: NM_004398 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004398
UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206Function: Putative ATP-dependent RNA helicaseEnzyme Number (IUBMB): EC 3.6.1.- Genatlas biochemistry entry for DDX10:DEAD/H box protein 10,ubiquitously expressed,fused with NUP98 in de novo or therapy related myeloid maligancies with inv 11(p15-q22)1 MGI phenotypic allele for Ddx10 (no phenotypes)
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for DDX10
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/14 Interacting proteins for DDX10 (ENSP000003143483) via UniProtKB, MINT, and/or STRING (see all 14
)About this table
|
Drugs & Compounds for DDX10(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for DDX10
|
Transcripts for DDX10(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004398
Sigma-Aldrich siRNA for DDX10  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004398 REFSEQ mRNAs for DDX10 gene: NM_004398.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004398               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004398                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004398                                  untagged cDNA clone in CMV expression vector: NM_004398  Additional cDNA sequence: AB000267.1 AB001343.1 AB040537.1 AB209884.1 AK296752.1 AK315216.1 AL833534.1 BC049217.1 BC064921.1 BC091521.1 BC093654.1 BC093656.1 U28042.1 5 DOTS entries: DT.310453 DT.97799397 DT.100782442 DT.100736227 DT.100782435 24/105 AceView cDNA sequences (see all 105
):BU159524 AA373519 BU539873 BM561644 NM_004398 BX283454 AB040537 BQ941659 BU170172 BC049217 BX489177 CA429323 BU159235 AA809921 BC064921 BU619096 BG821727 AA084582 BF934536 AL043665 CD654730 BU616591 CB163252 BX283469
highest scoring ESTs for DDX10:U28042 AA604373 AA629601 AB040537 AI376353 AI689145 AI758573 AI766144 AL043665 AL043712 Unigene Cluster for DDX10: DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 Hs.591931 [show with all ESTs]Unigene Representative Sequence: AB209884
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000322536
|
Expression for DDX10
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DDX10 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DDX10
1 / 2 / 3 3 probe-sets matching DDX10 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATTTCGACGT
SOURCE GeneReport for Unigene cluster: Hs.591931
Expression variation in blood from EXPOLDB for DDX10 UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206Tissue specificity: High in testis but widely expressed |
Orthologs for DDX10
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DDX10 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for DDX10
ENSEMBL Gene Tree for DDX10 | Paralogs for DDX10(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for DDX10 gene
- DDX182 DDX312 DDX552
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for DDX10(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for DDX10 (up to first 250kb)
|
Disorders & Mutations for DDX10
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601235
UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206
Defects in DDX10 may be a cause of breast cancer1 Novoseek disease relationship for DDX10 gene
About this table
1 PharmGKB disease relationship for DDX10 geneAbout this table
|
Medical News for DDX10(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for DDX10 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/21 PubMed articles for DDX10 gene (see all 21
):- A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. (PubMed id 8660968)2, 3, 4 Savitsky K.... Rotman G. (1996)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. (PubMed id 9166830)1, 3 Arai Y....Ohki M. (1997)
- Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome. (PubMed id 10830185)1, 3 Nakao K....Ohki M. (2000)
- The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. (PubMed id 10222653)1, 3 Ikeda T....Takahara J. (1999)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)4 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
|
Search for DDX10
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DDX10
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DDX10
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDX10(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for DDX10(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for DDX10:

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Incremental update: 13 Oct 2009
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