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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDX10 Gene

protein-coding   GIFtS: 59
GCID: GC11P108569

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 10

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 101 2     DEAD Box-102
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 10 (RNA Helicase)1 2     Probable ATP-Dependent RNA Helicase DDX102
DEAD Box Protein 102 3     EC 3.6.4.133
HRH-J82     EC 3.6.18
DDX10-NUP98 Fusion Protein Type 22     

External Ids:    HGNC: 27351   Entrez Gene: 16622   Ensembl: ENSG000001781057   OMIM: 6012355   UniProtKB: Q132063   

Export aliases for DDX10 gene to outside databases

Previous GC identifers: GC11P110792 GC11P109988 GC11P108073 GC11P108041 GC11P104461


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDX10 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome
assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation
is found in the patients with de novo or therapy-related myeloid malignancies. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX10 Gene: 
DDX10 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 10) is a protein-coding gene. Diseases associated with DDX10 include myelodysplastic syndromes, and acute myeloid leukemia. GO annotations related to this gene include RNA helicase activity and RNA binding.

UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206
Function: Putative ATP-dependent RNA helicase

Gene Wiki entry for DDX10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDX10 gene promoter:
         Pax-5   Tal-1   FOXD3   Nkx2-5   GATA-1   E47   CREB   POU2F1   POU2F1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX10 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDX10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22-q23

DDX10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P108569:  view genomic region     (about GC identifiers)

Start:
108,535,752 bp from pter      End:
108,811,657 bp from pter
Size:
275,906 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX10  
Size: 875 amino acids; 100888 Da
1 PDB 3D structure from and Proteopedia for DDX10:
2PL3 (3D)    
Secondary accessions: B2RCQ3 Q5BJD8

Explore the universe of human proteins at neXtProt for DDX10: NX_Q13206

Explore proteomics data for DDX10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13206

  • 4/10 DME Specific Peptides for DDX10 (Q13206) (see all 10)
     DLARLSL  DEADRIL  SPTRELA  IISPTREL 

    DDX10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDX10 Protein Expression
    REFSEQ proteins: NP_004389.2  
    ENSEMBL proteins: 
     ENSP00000314348   ENSP00000432032  

    Human Recombinant Protein Products for DDX10: 
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    Novus Biologicals DDX10 Protein
    Novus Biologicals DDX10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDX10 


    DDX10 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DDX10 

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    Cloud-Clone Corp. ELISAs for DDX10 
    Cloud-Clone Corp. CLIAs for DDX10


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DDX: DEAD-boxes

    5/7 InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR025313 DUF4217
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif

    Graphical View of Domain Structure for InterPro Entry Q13206

    ProtoNet protein and cluster: Q13206

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206
    Domain: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP
    binding and hydrolysis
    Similarity: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    DDX10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX10_HUMAN, Q13206
    Function: Putative ATP-dependent RNA helicase
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for DDX10:
    DEAD/H box protein 10,ubiquitously expressed,fused with NUP98 in de novo or therapy related myeloid maligancies
    with inv 11(p15-q22)

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0003724RNA helicase activity TAS8660968
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
         
    DDX10 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDX10:
     Decreased p24 protein expressi  Nucleolar pre-40S maturation d 

         1 MGI phenotypic allele for Ddx10 (no phenotypes)

    DDX10 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDX10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDX10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDX10 
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    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX10
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DDX10:
    hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidDDX10 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Browse Sino Biological Human cDNA Clones
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                         Customized lentivirus expression plasmids for stable overexpression of DDX10 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/145 Interacting proteins for DDX10 (Q132063 ENSP000003143484) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDX10

    Search CenterWatch for drugs/clinical trials and news about DDX10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDX10 gene: 
    NM_004398.3  

    Unigene Cluster for DDX10:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
    Hs.591931  [show with all ESTs]
    Unigene Representative Sequence: AB209884
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322536(uc001pkm.3) ENST00000534774 ENST00000526794(uc001pkl.1)
    ENST00000534439 ENST00000533198 ENST00000530116 ENST00000524979 ENST00000534221

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDX10
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DDX10:
    hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidDDX10 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDX10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX10
    Clone
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    GenScript: all cDNA clones in your preferred vector: DDX10 (NM_004398)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDX10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX10
    Sirion Biotech Customized lentivirus for stable overexpression of DDX10 
                         Customized lentivirus expression plasmids for stable overexpression of DDX10 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DDX10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX10

    Additional mRNA sequence: 

    AB000267.1 AB001343.1 AB040537.1 AB209884.1 AK296752.1 AK315216.1 AL833534.1 BC049217.1 
    BC064921.1 BC091521.1 BC093654.1 BC093656.1 U28042.1 

    5 DOTS entries:

    DT.310453  DT.97799397  DT.100782442  DT.100782435  DT.100736227 

    24/105 AceView cDNA sequences (see all 105):

    CB163252 BF934536 BC064921 AA373519 BU619096 AB040537 CA429323 AI376353 
    BU161207 BU539873 BU159524 BX283454 BG821727 BU616591 AL043665 NM_004398 
    AA604373 BM561644 AA084582 AA809921 CA422482 BX283469 BX489177 AL705075 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDX10 expression in normal human tissues (normalized intensities)      DDX10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCGACGT
    DDX10 Expression
    About this image


    DDX10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             testis ; cells in seminiferus ducts   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   

    See DDX10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDX10

    SOURCE GeneReport for Unigene cluster: Hs.591931

    UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206
    Tissue specificity: High in testis but widely expressed

        SABiosciences Custom PCR Arrays for DDX10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX10 gene from 10/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx101 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 101, 5 86.41(n)1
    85.53(a)1
      9 (29.12 cM)5
    775911  NM_029936.21  NP_084212.21 
     530984545 
    chicken
    (Gallus gallus)
    Aves DDX101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 70.5(n)
    67.94(a)
      418965  NM_001079725.1  NP_001073193.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDX106
    Uncharacterized protein
    69(a)
    1 ↔ 1
    5(125140170-125288719)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146812 Xenopus laevis transcribed sequence with moderate similarity more 78.49(n)    48050676 
    zebrafish
    (Danio rerio)
    Actinopterygii BM071107.12   -- 70.44(n)    BM071107.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58001 , 3 RNA helicase3
    CG58001
    51(a)
    (best of 2)3
    52.51(n)1
    48.34(a)1
      16B103
    327421  NM_133002.11  NP_573230.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y23H5B.61 , 3 Protein Y23H5B.61 52(a)
    (best of 2)3
    53.05(n)1
    45.9(a)1
      I(2489985-2497262)3
    1718101  NM_058588.31  NP_490989.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HCA4(YJL033W)4
    HCA41
    Putative nucleolar DEAD box RNA helicase; high-copy more4
    Hca4p1
    51.88(n)1
    44.23(a)1
      10(383837-386149)4
    8534191, 4  NP_012501.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G549101 DEAD-box ATP-dependent RNA helicase 32 53.36(n)
    44.53(a)
      835582  NM_124873.2  NP_200302.1 
    rice
    (Oryza sativa)
    Liliopsida Os.247082 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.32(n)    NM_187400.1 


    ENSEMBL Gene Tree for DDX10 (if available)
    TreeFam Gene Tree for DDX10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDX10 gene
    15 SIMAP similar genes for DDX10 using alignment to 3 protein entries:     DDX10_HUMAN (see all proteins):
    DDX18    DDX54    DDX56    DDX55    E4-DBP    DDX47
    DDX59    EIF4A2    DDX6    EIF4A1    MST162    DKFZp547B159
    EIF4A3    DKFZp564G1016    DDX49

    DDX10 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DDX10
    PGOHUM00000262839 PGOHUM00000258384


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5019 SNPs in DDX10 are shown (see all 5019)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358404
    A breast cancer sample4--see VAR_0358402 L V mis40--------
    rs584651361,2
    C--104704072(+) TTTTT-/T/TT  
            
    CCTTT
    1 -- int10--------
    rs730017411,2
    C,F--108533980(+) CATTTT/AAGCCA 1 -- us2k12Minor allele frequency- A:0.17NA EA 240
    rs1445454021,2
    C--108534138(+) TACTT-/TCTC  
            
    TATTA
    1 -- us2k10--------
    rs2009440871,2
    C--108534141(-) TAATAA/GANNNN 1 -- us2k10--------
    rs798516271,2
    C,F--108534222(+) TTCACT/GTAGCT 1 -- us2k12Minor allele frequency- G:0.18WA 120
    rs1881848891,2
    --108534365(+) GCTTCC/TACATT 1 -- us2k10--------
    rs118216181,2
    H--108534374(+) ttttaA/Gctata 1 -- us2k10--------
    rs1810874651,2
    --108534387(+) GCTGTA/GGTGAA 1 -- us2k10--------
    rs118240311,2
    H--108534398(+) cacggG/Tatgca 1 -- us2k1 tfbs30--------

    HapMap Linkage Disequilibrium report for DDX10 (108535752 - 108785752 bp, first 250kb of DDX10)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for DDX10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2675797CNV Deletion23128226
    esv2660905CNV Deletion23128226
    esv2673710CNV Deletion23128226
    nsv39083CNV Loss16902084
    esv23672CNV Loss19812545
    nsv826084CNV Gain20364138
    nsv898386CNV Gain21882294
    nsv898389CNV Gain21882294
    nsv898388CNV Gain21882294
    nsv832264CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601235    OMIM disorders: --

    4 diseases for DDX10:    About MalaCards
    myelodysplastic syndromes    acute myeloid leukemia    myeloid leukemia    leukemia


    DDX10 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DDX10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myelodysplastic syndromes 51.9 1 10830185 (1)

    Genetic Association Database (GAD): DDX10
    Human Genome Epidemiology (HuGE) Navigator: DDX10 (1 document)

    Export disorders for DDX10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDX10 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with DDX10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. (PubMed id 8660968)1, 2, 3 Savitsky K.... Rotman G. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. (PubMed id 9166830)1, 9 Arai Y....Ohki M. (1997)
    4. Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome. (PubMed id 10830185)1, 9 Nakao K....Ohki M. (2000)
    5. The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. (PubMed id 10222653)1, 9 Ikeda T....Takahara J. (1999)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)
    8. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1662 HGNC: 2735 AceView: DDX10 Ensembl:ENSG00000178105 euGenes: HUgn1662
    ECgene: DDX10 H-InvDB: DDX10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDX10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDX10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDX10 gene:
    Search GeneIP for patents involving DDX10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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