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Aliases for DDX10 Gene

Aliases for DDX10 Gene

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 10 2 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 10 (RNA Helicase) 2 3
  • DEAD Box Protein 10 3 4
  • DDX10-NUP98 Fusion Protein Type 2 3
  • DEAD Box-10 3
  • EC 3.6.4.13 4
  • EC 3.6.1 63
  • HRH-J8 3

External Ids for DDX10 Gene

Previous GeneCards Identifiers for DDX10 Gene

  • GC11P110792
  • GC11P109988
  • GC11P108073
  • GC11P108041
  • GC11P104461

Summaries for DDX10 Gene

Entrez Gene Summary for DDX10 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDX10 Gene

DDX10 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 10) is a Protein Coding gene. Diseases associated with DDX10 include myelodysplastic syndrome and leukemia, acute myeloid. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for DDX10 Gene

  • Putative ATP-dependent RNA helicase

Gene Wiki entry for DDX10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX10 Gene

Genomics for DDX10 Gene

Regulatory Elements for DDX10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDX10 Gene

Chromosome:
11
Start:
108,665,025 bp from pter
End:
108,940,930 bp from pter
Size:
275,906 bases
Orientation:
Plus strand

Genomic View for DDX10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDX10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX10 Gene

Proteins for DDX10 Gene

  • Protein details for DDX10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13206-DDX10_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX10
    Protein Accession:
    Q13206
    Secondary Accessions:
    • B2RCQ3
    • Q5BJD8

    Protein attributes for DDX10 Gene

    Size:
    875 amino acids
    Molecular mass:
    100888 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DDX10 Gene

neXtProt entry for DDX10 Gene

Proteomics data for DDX10 Gene at MOPED

Selected DME Specific Peptides for DDX10 Gene

Post-translational modifications for DDX10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for DDX10 Gene

Gene Families for DDX10 Gene

Suggested Antigen Peptide Sequences for DDX10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13206

UniProtKB/Swiss-Prot:

DDX10_HUMAN :
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis
  • Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
Domain:
  • The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.
genes like me logo Genes that share domains with DDX10: view

Function for DDX10 Gene

Molecular function for DDX10 Gene

GENATLAS Biochemistry:
DEAD/H box protein 10,ubiquitously expressed,fused with NUP98 in de novo or therapy related myeloid maligancies with inv 11(p15-q22)
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function:
Putative ATP-dependent RNA helicase

Enzyme Numbers (IUBMB) for DDX10 Gene

Gene Ontology (GO) - Molecular Function for DDX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003724 RNA helicase activity TAS 8660968
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DDX10: view

Phenotypes for DDX10 Gene

genes like me logo Genes that share phenotypes with DDX10: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX10

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DDX10 Gene

Localization for DDX10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDX10 Gene COMPARTMENTS Subcellular localization image for DDX10 gene
Compartment Confidence
cytoskeleton 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDX10 Gene

Pathways & Interactions for DDX10 Gene

SuperPathways for DDX10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010501 RNA secondary structure unwinding IBA --
genes like me logo Genes that share ontologies with DDX10: view

No data available for Pathways by source and SIGNOR curated interactions for DDX10 Gene

Drugs & Compounds for DDX10 Gene

(1) Drugs for DDX10 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for DDX10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDX10: view

Transcripts for DDX10 Gene

Unigene Clusters for DDX10 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDX10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDX10 Gene

No ASD Table

Relevant External Links for DDX10 Gene

GeneLoc Exon Structure for
DDX10
ECgene alternative splicing isoforms for
DDX10

Expression for DDX10 Gene

mRNA expression in normal human tissues for DDX10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDX10 Gene

This gene is overexpressed in Lung (10.9), Testis (6.9), Blymphocyte (6.7), Fetal heart (6.5), Frontal cortex (6.2), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDX10 Gene



SOURCE GeneReport for Unigene cluster for DDX10 Gene Hs.591931

mRNA Expression by UniProt/SwissProt for DDX10 Gene

Q13206-DDX10_HUMAN
Tissue specificity: High in testis but widely expressed
genes like me logo Genes that share expression patterns with DDX10: view

Protein tissue co-expression partners for DDX10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DDX10 Gene

Orthologs for DDX10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDX10 35
  • 89.32 (n)
  • 89.09 (a)
DDX10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDX10 35
  • 89.45 (n)
  • 89.15 (a)
DDX10 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx10 35
  • 86.22 (n)
  • 85.42 (a)
Ddx10 16
Ddx10 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDX10 35
  • 99.43 (n)
  • 99.09 (a)
DDX10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddx10 35
  • 86.44 (n)
  • 86.55 (a)
oppossum
(Monodelphis domestica)
Mammalia DDX10 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDX10 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX10 35
  • 70.59 (n)
  • 67.83 (a)
DDX10 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDX10 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx10 35
  • 66.06 (n)
  • 66.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14681 35
zebrafish
(Danio rerio)
Actinopterygii ddx10 35
  • 64.87 (n)
  • 66.01 (a)
ddx10 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5800 37
  • 51 (a)
CG9630 37
  • 38 (a)
CG5800 35
  • 53.46 (n)
  • 49.51 (a)
CG5800 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001057 35
  • 57.74 (n)
  • 54.82 (a)
worm
(Caenorhabditis elegans)
Secernentea Y23H5B.6 37
  • 52 (a)
ZK512.2 37
  • 33 (a)
Y23H5B.6 35
  • 54.22 (n)
  • 49.75 (a)
Y23H5B.6 36
  • 42 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCA4 36
  • 40 (a)
OneToOne
HCA4 38
rice
(Oryza sativa)
Liliopsida Os.24708 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10849 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for DDX10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX10 Gene

ENSEMBL:
Gene Tree for DDX10 (if available)
TreeFam:
Gene Tree for DDX10 (if available)

Paralogs for DDX10 Gene

(15) SIMAP similar genes for DDX10 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DDX10 Gene

genes like me logo Genes that share paralogs with DDX10: view

No data available for Paralogs for DDX10 Gene

Variants for DDX10 Gene

Sequence variations from dbSNP and Humsavar for DDX10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs723697 -- 108,877,021(-) AGCCA(C/T)TTCTT intron-variant
rs890237 -- 108,877,671(-) AATAT(A/T)GATCT intron-variant
rs890238 -- 108,916,443(+) AATAA(A/G)GGACT intron-variant
rs898972 -- 108,825,734(-) TAATC(C/T)ATAAT intron-variant
rs919038 -- 108,858,848(-) AGTAT(C/G)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX10 Gene

Variant ID Type Subtype PubMed ID
nsv898386 CNV Gain 21882294
nsv898388 CNV Gain 21882294
nsv832264 CNV Gain+Loss 17160897
esv2660905 CNV Deletion 23128226
esv2675797 CNV Deletion 23128226
nsv826084 CNV Gain 20364138
nsv898389 CNV Gain 21882294
nsv39083 CNV Loss 16902084
esv23672 CNV Loss 19812545
esv2673710 CNV Deletion 23128226

Variation tolerance for DDX10 Gene

Residual Variation Intolerance Score: 38.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX10 Gene

HapMap Linkage Disequilibrium report
DDX10
Human Gene Mutation Database (HGMD)
DDX10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX10 Gene

Disorders for DDX10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DDX10 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
myelodysplastic syndrome
  • myelodysplastic syndrome, somatic
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association
Search DDX10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DDX10

Genetic Association Database (GAD)
DDX10
Human Genome Epidemiology (HuGE) Navigator
DDX10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX10
genes like me logo Genes that share disorders with DDX10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DDX10 Gene

Publications for DDX10 Gene

  1. NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogenetique Hematologique. (PMID: 16467868) Romana S.P. … Berger R. (Leukemia 2006) 23 67
  2. Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome. (PMID: 10830185) Nakao K. … Ohki M. (Intern. Med. 2000) 23 67
  3. The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. (PMID: 10222653) Ikeda T. … Takahara J. (Int. J. Hematol. 1999) 23 67
  4. NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15). (PMID: 10397741) Nakamura T. … Miura I. (Blood 1999) 23 67
  5. 11p15 translocations involving the NUP98 gene in childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome. (PMID: 10502319) Nishiyama M. … Kaneko Y. (Genes Chromosomes Cancer 1999) 23 67

Products for DDX10 Gene

Sources for DDX10 Gene

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