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DDX10 Gene

protein-coding   GIFtS: 59
GCID: GC11P108569

DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 10

(Previous name: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 10 (RNA helicase))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 101 2     DEAD Box-102
DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 10 (RNA Helicase)1 2     Probable ATP-Dependent RNA Helicase DDX102
DEAD Box Protein 102 3     EC 3.6.4.133
HRH-J82     EC 3.6.18
DDX10-NUP98 Fusion Protein Type 22     

External Ids:    HGNC: 27351   Entrez Gene: 16622   Ensembl: ENSG000001781057   OMIM: 6012355   UniProtKB: Q132063   

Export aliases for DDX10 gene to outside databases

Previous GC identifers: GC11P110792 GC11P109988 GC11P108073 GC11P108041 GC11P104461


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDX10 Gene:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They
are implicated in a number of cellular processes involving alteration of RNA secondary structure such as
translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their
distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis,
and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome
assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation
is found in the patients with de novo or therapy-related myeloid malignancies. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDX10 Gene:
DDX10 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 10) is a protein-coding gene. GO annotations related to this gene include RNA helicase activity and RNA binding.

UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206
Function: Putative ATP-dependent RNA helicase

Gene Wiki entry for DDX10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDX10 gene promoter:
         Pax-5   Tal-1   FOXD3   Nkx2-5   GATA-1   E47   CREB   POU2F1   POU2F1a   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDX10 promoter sequence
   Search Chromatin IP Primers for DDX10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDX10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22-q23   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22-q23

DDX10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDX10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P108569:  view genomic region     (about GC identifiers)

Start:
108,535,752 bp from pter      End:
108,811,657 bp from pter
Size:
275,906 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206 (See protein sequence)
Recommended Name: Probable ATP-dependent RNA helicase DDX10  
Size: 875 amino acids; 100888 Da
1 PDB 3D structure from and Proteopedia for DDX10:
2PL3 (3D)    
Secondary accessions: B2RCQ3 Q5BJD8

Explore the universe of human proteins at neXtProt for DDX10: NX_Q13206

Explore proteomics data for DDX10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDX10 (Q13206) (see all 10)
     DLARLSL  DEADRIL  SPTRELA  IISPTREL 


    See DDX10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004389.2  
    ENSEMBL proteins: 
     ENSP00000314348   ENSP00000432032  

    DDX10 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DDX10

     
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    antibodies-online antibodies for DDX10 (4 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DDX: DEAD-boxes

    Selected InterPro protein domains (see all 7):
     IPR011545 DNA/RNA_helicase_DEAD/DEAH_N
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR025313 DUF4217
     IPR027417 P-loop_NTPase
     IPR014014 RNA_helicase_DEAD_Q_motif

    Graphical View of Domain Structure for InterPro Entry Q13206

    ProtoNet protein and cluster: Q13206

    1 Blocks protein domain: IPB000629 ATP-dependent helicase

    UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206
    Domain: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP
    binding and hydrolysis
    Similarity: Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with DDX10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDX10_HUMAN, Q13206
    Function: Putative ATP-dependent RNA helicase
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for DDX10:
    DEAD/H box protein 10,ubiquitously expressed,fused with NUP98 in de novo or therapy related myeloid maligancies
    with inv 11(p15-q22)

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.131

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003724RNA helicase activity TAS8660968
    GO:0004386helicase activity ----
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with DDX10           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDX10:
     Decreased p24 protein expressi  Nucleolar pre-40S maturation d 

         1 MGI phenotypic allele for Ddx10 (no phenotypes)

    Find genes that share phenotypes with DDX10           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DDX10

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDX10:
    hsa-let-7b-5p (MIRT032410), hsa-mir-155-5p (MIRT020829), hsa-mir-98-5p (MIRT027606), hsa-mir-34a-5p (MIRT025474), hsa-mir-30a-5p (MIRT028567)

    Block miRNA regulation of human, mouse, rat DDX10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DDX10:
    hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidDDX10 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDX10
    Interactions:

        Search GeneGlobe Interaction Network for DDX10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDX10 (Q132063 ENSP000003143484) via UniProtKB, MINT, STRING, and/or I2D (see all 307)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process TAS8660968

    Find genes that share ontologies with DDX10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDX10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDX10 gene: 
    NM_004398.3  

    Unigene Cluster for DDX10:

    DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
    Hs.591931  [show with all ESTs]
    Unigene Representative Sequence: AB209884
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322536(uc001pkm.3) ENST00000534774 ENST00000526794(uc001pkl.1)
    ENST00000534439 ENST00000533198 ENST00000530116 ENST00000524979 ENST00000534221

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate DDX10:
    hsa-miR-1266
    SwitchGear 3'UTR luciferase reporter plasmidDDX10 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DDX10
      QuantiFast Probe-based Assays in human, mouse, rat DDX10

    Additional mRNA sequence: 

    AB000267.1 AB001343.1 AB040537.1 AB209884.1 AK296752.1 AK315216.1 AL833534.1 BC049217.1 
    BC064921.1 BC091521.1 BC093654.1 BC093656.1 U28042.1 

    5 DOTS entries:

    DT.310453  DT.97799397  DT.100782442  DT.100782435  DT.100736227 

    Selected AceView cDNA sequences (see all 105):

    BC049217 AI758573 BU616591 BM561644 BX489177 BX283469 BQ928472 BX283454 
    CA429323 AA809921 BC064921 BU159524 AI376353 AA084582 AA373519 CB163252 
    AB040537 BG821727 CA422482 BU161207 BU539873 BU619096 BF934536 AA604373 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDX10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCGACGT
    DDX10 Expression
    About this image


    DDX10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
    DDX10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDX10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591931

    UniProtKB/Swiss-Prot: DDX10_HUMAN, Q13206
    Tissue specificity: High in testis but widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDX10 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddx101 , 5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 101, 5 86.22(n)1
    85.42(a)1
      9 (29.12 cM)5
    775911  NM_029936.21  NP_084212.21 
     530984545 
    chicken
    (Gallus gallus)
    Aves DDX101 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 70.59(n)
    67.83(a)
      418965  NM_001079725.1  NP_001073193.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDX106
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
    70(a)
    1 ↔ 1
    5(125140170-125288719)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146812 Xenopus laevis transcribed sequence with moderate similarity more 78.49(n)    48050676 
    zebrafish
    (Danio rerio)
    Actinopterygii BM071107.12   -- 70.44(n)    BM071107.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58001 , 3 RNA helicase3
    CG58001
    51(a)
    (best of 2)3
    53.46(n)1
    49.51(a)1
      16B103
    327421  NM_133002.21  NP_573230.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y23H5B.61 , 3 Y23H5B.61 52(a)
    (best of 2)3
    54.22(n)1
    49.75(a)1
      I(2489985-2497262)3
    1718101  NM_058588.41  NP_490989.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HCA4(YJL033W)4 Putative nucleolar DEAD box RNA helicase; high-copy more   --   10(383837-386149) 853419  NP_012501.1 
    rice
    (Oryza sativa)
    Liliopsida Os.247082 Oryza sativa (japonica cultivar-group) cDNA clone0 more 71.32(n)    NM_187400.1 


    ENSEMBL Gene Tree for DDX10 (if available)
    TreeFam Gene Tree for DDX10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDX10 gene
    15 SIMAP similar genes for DDX10 using alignment to 3 protein entries:     DDX10_HUMAN (see all proteins):
    DDX18    DDX54    DDX56    DDX55    E4-DBP    DDX47
    DDX59    EIF4A2    DDX6    EIF4A1    MST162    DKFZp547B159
    EIF4A3    DKFZp564G1016    DDX49

    Find genes that share paralogs with DDX10           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for DDX10
    PGOHUM00000262839 PGOHUM00000258384


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDX10 (see all 5019)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358404
    A breast cancer sample4--see VAR_0358402 L V mis40--------
    rs584651361,2
    C--104704072(+) TTTTT-/T/TT  
            
    CCTTT
    1 -- int10--------
    rs730017411,2
    C,F--108533980(+) CATTTT/AAGCCA 1 -- us2k12Minor allele frequency- A:0.17NA EA 240
    rs1445454021,2
    C--108534138(+) TACTT-/TCTC  
            
    TATTA
    1 -- us2k10--------
    rs2009440871,2
    C--108534141(-) TAATAA/GANNNN 1 -- us2k10--------
    rs798516271,2
    C,F--108534222(+) TTCACT/GTAGCT 1 -- us2k12Minor allele frequency- G:0.18WA 120
    rs1881848891,2
    --108534365(+) GCTTCC/TACATT 1 -- us2k10--------
    rs118216181,2
    H--108534374(+) ttttaA/Gctata 1 -- us2k10--------
    rs1810874651,2
    --108534387(+) GCTGTA/GGTGAA 1 -- us2k10--------
    rs118240311,2
    H--108534398(+) cacggG/Tatgca 1 -- us2k1 tfbs30--------

    HapMap Linkage Disequilibrium report for DDX10 (108535752 - 108785752 bp, first 250kb of DDX10)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for DDX10:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675797CNV Deletion23128226
    esv2660905CNV Deletion23128226
    esv2673710CNV Deletion23128226
    nsv39083CNV Loss16902084
    esv23672CNV Loss19812545
    nsv826084CNV Gain20364138
    nsv898386CNV Gain21882294
    nsv898389CNV Gain21882294
    nsv898388CNV Gain21882294
    nsv832264CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601235    OMIM disorders: --


    Find genes that share disorders with DDX10           About GenesLikeMe

    1 Novoseek inferred disease relationship for DDX10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myelodysplastic syndromes 51.9 1 10830185 (1)

    Genetic Association Database (GAD): DDX10
    Human Genome Epidemiology (HuGE) Navigator: DDX10 (1 document)

    Export disorders for DDX10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDX10 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with DDX10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. (PubMed id 8660968)1, 2, 3 Savitsky K.... Rotman G. (Genomics 1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10. (PubMed id 9166830)1, 9 Arai Y....Ohki M. (Blood 1997)
    4. Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome. (PubMed id 10830185)1, 9 Nakao K....Ohki M. (Intern. Med. 2000)
    5. The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts. (PubMed id 10222653)1, 9 Ikeda T....Takahara J. (Int. J. Hematol. 1999)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (J. Proteome Res. 2012)
    9. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C.... Cristea I.M. (Mol. Cell. Proteomics 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1662 HGNC: 2735 AceView: DDX10 Ensembl:ENSG00000178105 euGenes: HUgn1662
    ECgene: DDX10 H-InvDB: DDX10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDX10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDX10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDX10 gene:
    Search GeneIP for patents involving DDX10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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