DDX1 Gene
protein-coding GIFtS: 60
GCID: GC02P015731
|
|
DEAD (Asp-Glu-Ala-Asp) box helicase 1(Previous names: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1, DEAD (Asp-Glu-Ala-Asp)...)
| |
Aliases
for DDX1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DEAD (Asp-Glu-Ala-Asp) Box Helicase 11 2 | | ATP-Dependent RNA Helicase DDX12 | | DBP-RB1 2 3 | | DEAD Box Polypeptide 12 | | DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 11 2 | | DEAD Box-12 | | DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 2 | | EC 3.6.4.133 | | DEAD Box Protein 12 3 | | EC 3.6.18 | | DEAD Box Protein Retinoblastoma2 3 | | EC 3.6.1.108 | | UKVH5d2 | | |
Export aliases for DDX1 gene to outside databasesPrevious GC identifers: GC02P015736 GC02P015753 GC02P015682 |
Summaries
for DDX1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DDX1:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They areimplicated in a number of cellular processes involving alteration of RNA secondary structure such as translationinitiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distributionpatterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellulargrowth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2retinoblastoma cell lines and in tissues of neuroectodermal origin. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DDX1_HUMAN, Q92499Function: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5'single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides.May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repairof transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhanceNF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region viaassociation with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs.Required for HIV-1 Rev function as well as for HIV-1 replication. Binds to the RRE sequence of HIV-1 mRNAs
Gene Wiki entry for DDX1
|
Genomic Views
for DDX1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005334.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDX1 gene promoter:
TBP Elk-1 NCX/Ncx HNF-1A HEN1 PPAR-gamma1 NRF-2 Nkx6-1 HNF-1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDX1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p24 Ensembl cytogenetic band: 2p24.3 HGNC cytogenetic band: 2p24DDX1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P015731: view genomic region
(about GC identifiers)
Start:
|
15,731,302 bp from pter |
End:
|
15,771,225 bp from pter |
Size:
|
39,924 bases |
Orientation:
|
plus strand |
|
Proteins
for DDX1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDX1_HUMAN, Q92499 (See
protein sequence)Recommended Name: ATP-dependent RNA helicase DDX1 Size: 740 amino acids; 82432 Da
Subunit: Interacts with PHF5A (via C-terminus) (By similarity). Interacts with MBNL1. Interacts with CSTF2. Interactswith HNRNPK. Interacts with ATM. Interacts with RELA (via C-terminus). Interacts (via C-terminus) with the replicasepolyprotein 1ab Nsp14 of the avian infectious bronchitis virus (IBV). Interacts with Rev of HIV-1. Interacts withsevere acute respiratory syndrome coronavirus (SARS-CoV) (via N-terminus). Component of the tRNA-splicing ligasecomplex
Subcellular location: Nucleus. Cytoplasm. Cytoplasmic granule. Note=Localized with MBNL1, TIAL1 and YBX1 in stressgranules upon stress. Localized with CSTF2 in cleavage bodies. Forms large aggregates called DDX1 bodies. Relocalizedinto multiple foci (IR-induced foci or IRIF) after IR treatment, a process that depends on the presence of chromosomalDNA and/or RNA-DNA duplexes. Relocalized at sites of DNA double-strand breaks (DSBs) in an ATM-dependent manner afterIR treatment. Colocalized with RELA in the nucleus upon TNF-alpha induction. Relocalized to the cytoplasm with aperinuclear staining pattern in avian infectious bronchitis virus (IBV)-infected cells. Required for properlocalization of HIV-1 Rev
Caution: According to some authors the unwinding activity is ADP-dependent and not ATP-dependent (PubMed:18710941)Explore the universe of human proteins at neXtProt for DDX1: NX_Q92499
Post-translational modifications:
Phosphorylated. Phosphorylated by ATM kinase; phosphorylation is increased in response to ionizing radiation (IR)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92499
4/34 DME Specific Peptides for DDX1 (Q92499) (see all 34)
DDX1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004930.1
ENSEMBL proteins: ENSP00000370745 ENSP00000413767 ENSP00000233084
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
DDX1 for ontologies About GeneDecksing
DDX1 Antibody Products:
Assay Products for DDX1: |
Protein
Domains /
Families
for DDX1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDX1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q92499ProtoNet protein and cluster: Q92499 1 Blocks protein family: IPB000629 ATP-dependent helicase
UniProtKB/Swiss-Prot: DDX1_HUMAN, Q92499Domain: The helicase domain is involved in the stimulation of RELA transcriptional activitySimilarity: Belongs to the DEAD box helicase family. DDX1 subfamilySimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domain |
Function
for DDX1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DDX1_HUMAN, Q92499Function: Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5'single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides.May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repairof transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhanceNF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region viaassociation with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs.Required for HIV-1 Rev function as well as for HIV-1 replication. Binds to the RRE sequence of HIV-1 mRNAsCatalytic activity: ATP + H(2)O = ADP + phosphate Genatlas biochemistry entry for DDX1:DEAD/H box protein 1,frequently amplified in retinoblastoma,neuroblastoma,small cell carcinoma of the lung,with poorprognosis
Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.1.102 EC 3.6.4.131
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DDX1 (NM_004939) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX1 |
Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13): About this table
DDX1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for DDX1:
|
Pathways & Interactions
for DDX1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA Splicing - Major Pathway | |
1  BioSystems Pathway for DDX1
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDX1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/624 Interacting proteins for DDX1 (Q924992, 3 ENSP000002330844) via UniProtKB, MINT, STRING, and/or I2D (see all 624)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
DDX1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DDX1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DDX1 for compounds About GeneDecksing
 Browse Tocris compounds for DDX1
1 Novoseek chemical compound relationship for DDX1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ornithine |
29.7 |
3 |
8622876 (2), 9516849 (1) |
Search CenterWatch for drugs/clinical trials and news about DDX1
|
Transcripts
for DDX1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DDX1 gene: NM_004939.2 Unigene Cluster for DDX1: DEAD (Asp-Glu-Ala-Asp) box helicase 1 Hs.440599 [show with all ESTs]Unigene Representative Sequence: NM_0049396 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000381341 ENST00000434671 ENST00000459706 ENST00000470674 ENST00000478695
ENST00000233084(uc010yjq.1 uc002rce.3 uc021vee.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DDX1 (NM_004939) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDX1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX1 |
Additional cDNA sequence: AB073360.1 AB593031.1 AB593032.1 AB593033.1 AB593034.1 AK297432.1 AK298212.1 AK298426.1 AK313933.1 BC012132.1 BC012739.2 BC053673.1 EF418570.1 EF418571.1 X70649.1 19 DOTS entries: DT.216759 DT.97781891 DT.121033032 DT.216760 DT.121033071 DT.121032940 DT.92456116 DT.95370517 DT.100836226 DT.121032951 DT.92456115 DT.100661145 DT.100782941 DT.121032866 DT.121032966 DT.121032987 DT.86845309 DT.95283542 DT.97857850 24/613 AceView cDNA sequences (see all 613): BI819059 AI001170 BQ431462 BQ012281 BE794719 BQ068892 BF001359 BE784443 BQ068757 BU150851 BU167745 BQ071940 CB137442 BM451829 BI492047 NM_004939 BQ071203 CR598216 BX457707 BM667077 BG742257 CA951149 BG762760 CB131864
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DDX1 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
| ExUns: | 22 | ^ | 23a | · | 23b | · | 23c | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b |
|---|
|
| SP1: | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DDX1
|
Expression
for DDX1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAAGAAACA
About this image
See DDX1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDX1
SOURCE GeneReport for Unigene cluster: Hs.440599
UniProtKB/Swiss-Prot: DDX1_HUMAN, Q92499Tissue specificity: Highest levels of transcription in 2 retinoblastoma cell lines and in tissues of neuroectodermalorigin including the retina, brain, and spinal cord
SABiosciences Custom PCR Arrays for DDX1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX1 |
Orthologs
for DDX1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DDX1 gene from 6/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DDX11 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 |
83.06(n)
93.24(a) |
|
395249 NM_204563.1 NP_989894.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DDX16 |
-- |
90(a) |
1 ↔ 1 |
1(144532860-144560410) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.15452 |
Xenopus laevis transcribed sequence with moderate similarity more |
78.77(n) |
|
CA973691.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.194662 |
Transcribed sequence with moderate similarity to protein more |
76.87(n) |
|
CB357242.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Ddx11 , 3 |
regulation of translational initiation
helicase3
Dead-box-11 |
58(a)3
57.75(n)1
60.86(a)1 |
|
3 79D33
404571 NM_079488.41 NP_524212.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y55F3BR.11 , 3 |
Protein Y55F3BR.11 |
47(a)
(best of 2)3
53.38(n)1
50.35(a)1 |
|
IV(874988-881841)3
1769131 NM_067603.51 NP_500004.21 |
ENSEMBL Gene Tree for DDX1 (if available)
TreeFam Gene Tree for DDX1 (if available) |
Paralogs
for DDX1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DDX1 gene
- DDX412 DDX52 DDX172 DDX432 DDX532
2 SIMAP similar genes for DDX1 using alignment to 4 protein entries: DDX1_HUMAN (see all proteins):DDX59 DDX39B
DDX1 for paralogs About GeneDecksing
|
Genomic Variants
for DDX1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DDX1 (15731302 - 15771225 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DDX1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX1 |
|
Disorders
/ Diseases
for DDX1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DDX1 for disorders About GeneDecksing
OMIM gene information: 601257
OMIM disorders: --
16  diseases for DDX1: About MalaCardsretinoblastoma heavy chain disease b-cell lymphomas alveolar rhabdomyosarcoma
small cell carcinoma rhabdomyosarcoma hepatitis c medulloblastoma
prostate cancer breast cancer glioblastoma hepatitis
neuroblastoma prostatitis carcinoma malaria
1 disease from the University of Copenhagen DISEASES database for DDX1:Neuroblastoma 3 Novoseek disease relationships for DDX1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: DDX1 (2 documents)
Export disorders for DDX1 gene to outside databases
|
Publications
for DDX1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DDX1 gene, integrated from 9 sources (see all 92):
(articles sorted by number of sources associating them with DDX1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription. (PubMed id 19058135)1, 2, 3, 9 Ishaq M....Guo D. (2009)
- Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA. (PubMed id 11598190)1, 2, 9 Bleoo S....Godbout R. (2001)
- MBNL1 associates with YB-1 in cytoplasmic stress granules. (PubMed id 18335541)1, 2, 9 Onishi H.... Ishiura S. (2008)
- The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication. (PubMed id 20573827)1, 2 Xu L.... Liu D.X. (2010)
- A role for DEAD box 1 at DNA double-strand breaks. (PubMed id 18710941)1, 2 Li L....Godbout R. (2008)
- A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev. (PubMed id 15567440)1, 2 Fang J....Pomerantz R.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K. (PubMed id 12183465)1, 2 Chen H.C....Chang C.J. (2002)
- Amplification of a DEAD box protein gene in retinoblastoma cell lines. (PubMed id 7689221)1, 2 Godbout R. and Squire J. (1993)
- D-E-A-D protein family of putative RNA helicases. (PubMed id 1552844)1, 3 Schmid S.R. and Linder P. (1992)
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External Searches for DDX1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing DDX1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing DDX1 gene
(According to HUGE)
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Specialized Databases showing DDX1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for DDX1 gene:
Search GeneIP for patents involving DDX1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DDX1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DDX1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDX1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDX1 | | | OriGene Protein Over-expression Lysate for DDX1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DDX1 | | OriGene 3'-UTR Clone for DDX1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDX1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDX1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DDX1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DDX1 | | OriGene Custom Protein Services for DDX1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDX1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDX1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDX1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDX1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDX1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDX1 |
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| | | | Search Tocris compounds for DDX1 |
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 | | | DDX1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDX1 |
|  |  |  | | | | ThermoFisher Antibodies for DDX1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDX1 |
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