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Aliases for DDTL Gene

Aliases for DDTL Gene

  • D-Dopachrome Tautomerase-Like 2 3 5
  • D-Dopachrome Tautomerase-Like Protein 3 4
  • D-Dopachrome Decarboxylase-Like Protein 2
  • KB-226F1.2 3
  • EC 4.1.1.- 4

External Ids for DDTL Gene

Previous GeneCards Identifiers for DDTL Gene

  • GC22U900384
  • GC22P022639
  • GC22P024309
  • GC22P007252

Summaries for DDTL Gene

GeneCards Summary for DDTL Gene

DDTL (D-Dopachrome Tautomerase-Like) is a Protein Coding gene. GO annotations related to this gene include lyase activity. An important paralog of this gene is MIF.

UniProtKB/Swiss-Prot for DDTL Gene

  • May have lyase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDTL Gene

Genomics for DDTL Gene

Regulatory Elements for DDTL Gene

Enhancers for DDTL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDTL on UCSC Golden Path with GeneCards custom track

Promoters for DDTL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDTL on UCSC Golden Path with GeneCards custom track

Genomic Location for DDTL Gene

23,966,838 bp from pter
23,972,559 bp from pter
5,722 bases
Plus strand

Genomic View for DDTL Gene

Genes around DDTL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDTL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDTL Gene

Proteins for DDTL Gene

  • Protein details for DDTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    D-dopachrome decarboxylase-like protein
    Protein Accession:
    Secondary Accessions:
    • B4DJJ7

    Protein attributes for DDTL Gene

    134 amino acids
    Molecular mass:
    14195 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDTL Gene

Proteomics data for DDTL Gene at MOPED

Post-translational modifications for DDTL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDTL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDTL Gene

Domains & Families for DDTL Gene

Protein Domains for DDTL Gene

Suggested Antigen Peptide Sequences for DDTL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MIF family.
  • Belongs to the MIF family.
genes like me logo Genes that share domains with DDTL: view

No data available for Gene Families for DDTL Gene

Function for DDTL Gene

Molecular function for DDTL Gene

UniProtKB/Swiss-Prot Function:
May have lyase activity.

Enzyme Numbers (IUBMB) for DDTL Gene

Phenotypes for DDTL Gene

GenomeRNAi human phenotypes for DDTL:
genes like me logo Genes that share phenotypes with DDTL: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDTL Gene

Localization for DDTL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDTL Gene


Subcellular locations from

Jensen Localization Image for DDTL Gene COMPARTMENTS Subcellular localization image for DDTL gene
Compartment Confidence
extracellular 5
cytosol 3
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for DDTL Gene

Pathways & Interactions for DDTL Gene

SuperPathways for DDTL Gene

No Data Available

Interacting Proteins for DDTL Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000215770 for DDTL Gene via STRING

Gene Ontology (GO) - Biological Process for DDTL Gene


No data available for Pathways by source and SIGNOR curated interactions for DDTL Gene

Drugs & Compounds for DDTL Gene

No Compound Related Data Available

Transcripts for DDTL Gene

mRNA/cDNA for DDTL Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDTL Gene

D-dopachrome tautomerase-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDTL Gene

No ASD Table

Relevant External Links for DDTL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDTL Gene

mRNA expression in normal human tissues for DDTL Gene

mRNA differential expression in normal tissues according to GTEx for DDTL Gene

This gene is overexpressed in Heart - Left Ventricle (x6.2).

Protein differential expression in normal tissues from HIPED for DDTL Gene

This gene is overexpressed in Liver, secretome (44.8) and Liver (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DDTL Gene

SOURCE GeneReport for Unigene cluster for DDTL Gene Hs.744172

genes like me logo Genes that share expression patterns with DDTL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DDTL Gene

Orthologs for DDTL Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDTL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC747294 35
  • 95.79 (n)
  • 94.74 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
(Mus musculus)
Mammalia Ddt 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
(Gallus gallus)
Aves DDT 36
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
(Danio rerio)
Actinopterygii ddt 36
  • 41 (a)
Species with no ortholog for DDTL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDTL Gene

Gene Tree for DDTL (if available)
Gene Tree for DDTL (if available)

Paralogs for DDTL Gene

Paralogs for DDTL Gene

(2) SIMAP similar genes for DDTL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDTL: view

Variants for DDTL Gene

Sequence variations from dbSNP and Humsavar for DDTL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs9620341 -- 23,970,400(+) tgggt(A/G)GATAA intron-variant
rs9624362 -- 23,967,433(+) AGCGG(A/G)TCCAC reference, synonymous-codon
rs9624363 -- 23,969,149(+) CATGA(A/G)GTAGA intron-variant, downstream-variant-500B
rs76904099 -- 23,969,309(+) GTGGT(G/T)GGGGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DDTL Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
dgv1390e1 CNV Complex 17122850
nsv3578 CNV Loss 18451855
nsv197 CNV Loss 15895083
dgv4909n71 CNV Gain 21882294
nsv469844 CNV Complex 16826518
dgv4910n71 CNV Gain+Loss 21882294
nsv914610 CNV Gain 21882294
dgv4911n71 CNV Loss 21882294
nsv436348 CNV Deletion 17901297
esv999560 CNV Deletion 20482838
esv2430597 CNV Loss 19546169
esv22760 CNV Gain+Loss 19812545
esv2593346 CNV Deletion 19546169
nsv512650 CNV Loss 21212237
nsv829105 CNV Loss 20364138
esv2724066 CNV Deletion 23290073
nsv9878 CNV Gain+Loss 18304495
esv2667916 CNV Deletion 23128226
dgv35n47 CNV Loss 21111241
esv6716 CNV Loss 19470904
esv2421686 OTHER Complex 20811451
nsv442792 CNV CNV 18776908
essv6078 CNV CNV 17122850
esv2656467 CNV Deletion 23128226
nsv511643 CNV Loss 21212237
esv2656800 CNV Deletion 23128226
nsv471423 CNV Duplication 19718026
nsv482073 CNV Gain 20164927
dgv751n67 CNV Loss 20364138
nsv914614 CNV Loss 21882294
dgv826e199 CNV Deletion 23128226
nsv829109 CNV Loss 20364138
dgv4912n71 CNV Gain 21882294
nsv914616 CNV Gain 21882294

Variation tolerance for DDTL Gene

Gene Damage Index Score: 1.72; 32.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDTL Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDTL Gene

Disorders for DDTL Gene

Relevant External Links for DDTL

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDTL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDTL Gene

Publications for DDTL Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 67
  2. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M. … Board P. (Biochem. J. 1998) 2 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PMID: 22001757) Chambers J.C. … Kooner J.S. (Nat. Genet. 2011) 3

Products for DDTL Gene

Sources for DDTL Gene