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Aliases for DDTL Gene

Aliases for DDTL Gene

  • D-Dopachrome Tautomerase-Like 2 3
  • D-Dopachrome Decarboxylase-Like Protein 2 3
  • D-Dopachrome Tautomerase-Like Protein 3 4
  • KB-226F1.2 3
  • EC 4.1.1.- 4

External Ids for DDTL Gene

Previous GeneCards Identifiers for DDTL Gene

  • GC22U900384
  • GC22P022639
  • GC22P024309
  • GC22P007252

Summaries for DDTL Gene

GeneCards Summary for DDTL Gene

DDTL (D-Dopachrome Tautomerase-Like) is a Protein Coding gene. GO annotations related to this gene include lyase activity. An important paralog of this gene is DDT.

UniProtKB/Swiss-Prot for DDTL Gene

  • May have lyase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDTL Gene

Genomics for DDTL Gene

Regulatory Elements for DDTL Gene

Genomic Location for DDTL Gene

Start:
23,966,838 bp from pter
End:
23,972,559 bp from pter
Size:
5,722 bases
Orientation:
Plus strand

Genomic View for DDTL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDTL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDTL Gene

Proteins for DDTL Gene

  • Protein details for DDTL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHG4-DDTL_HUMAN
    Recommended name:
    D-dopachrome decarboxylase-like protein
    Protein Accession:
    A6NHG4
    Secondary Accessions:
    • B4DJJ7

    Protein attributes for DDTL Gene

    Size:
    134 amino acids
    Molecular mass:
    14195 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDTL Gene

Proteomics data for DDTL Gene at MOPED

Post-translational modifications for DDTL Gene

  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for DDTL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDTL Gene

Domains for DDTL Gene

Protein Domains for DDTL Gene

Suggested Antigen Peptide Sequences for DDTL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHG4

UniProtKB/Swiss-Prot:

DDTL_HUMAN :
  • A6NHG4
Family:
  • Belongs to the MIF family.
genes like me logo Genes that share domains with DDTL: view

No data available for Gene Families for DDTL Gene

Function for DDTL Gene

Molecular function for DDTL Gene

UniProtKB/Swiss-Prot Function: May have lyase activity.

Enzyme Numbers (IUBMB) for DDTL Gene

Gene Ontology (GO) - Molecular Function for DDTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with DDTL: view

Animal Model Products

CRISPR Products

miRNA for DDTL Gene

miRTarBase miRNAs that target DDTL

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DDTL Gene

Localization for DDTL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDTL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDTL Gene COMPARTMENTS Subcellular localization image for DDTL gene
Compartment Confidence
cytosol 3
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DDTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with DDTL: view

Pathways for DDTL Gene

SuperPathways for DDTL Gene

No Data Available

Interacting Proteins for DDTL Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000215770%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000216802%0d%0a9606.ENSP00000384863%0d%0a9606.ENSP00000418447%0d%0a
Selected Interacting proteins: ENSP00000215770 for DDTL Gene via STRING

Gene Ontology (GO) - Biological Process for DDTL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with DDTL: view

No data available for Pathways by source for DDTL Gene

Transcripts for DDTL Gene

mRNA/cDNA for DDTL Gene

(4) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDTL Gene

D-dopachrome tautomerase-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDTL

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DDTL
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDTL Gene

No ASD Table

Relevant External Links for DDTL Gene

GeneLoc Exon Structure for
DDTL
ECgene alternative splicing isoforms for
DDTL

Expression for DDTL Gene

mRNA expression in normal human tissues for DDTL Gene

mRNA differential expression in normal tissues according to GTEx for DDTL Gene

This gene is overexpressed in Heart - Left Ventricle (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DDTL Gene

SOURCE GeneReport for Unigene cluster for DDTL Gene Hs.744172

genes like me logo Genes that share expressions with DDTL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DDTL Gene

Orthologs for DDTL Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDTL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC747294 35
  • 95.79 (n)
  • 94.74 (a)
mouse
(Mus musculus)
Mammalia Ddt 36
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
chicken
(Gallus gallus)
Aves DDT 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ddt 36
  • 41 (a)
OneToMany
Species with no ortholog for DDTL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDTL Gene

ENSEMBL:
Gene Tree for DDTL (if available)
TreeFam:
Gene Tree for DDTL (if available)

Paralogs for DDTL Gene

Paralogs for DDTL Gene

Selected SIMAP similar genes for DDTL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDTL: view

Variants for DDTL Gene

Sequence variations from dbSNP and Humsavar for DDTL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs4822466 -- 23,970,015(+) ACAGG(A/G)AAGGG intron-variant, downstream-variant-500B
rs9620341 -- 23,970,400(+) tgggt(A/G)GATAA intron-variant
rs9624362 -- 23,967,433(+) AGCGG(A/G)TCCAC synonymous-codon, reference
rs9624363 -- 23,969,149(+) CATGA(A/G)GTAGA intron-variant, utr-variant-3-prime
rs9624364 -- 23,969,285(+) TGTTG(A/G)CTTAT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDTL Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
dgv1390e1 CNV Complex 17122850
nsv3578 CNV Loss 18451855
nsv197 CNV Loss 15895083
dgv4909n71 CNV Gain 21882294
nsv469844 CNV Complex 16826518
dgv4910n71 CNV Gain+Loss 21882294
nsv914610 CNV Gain 21882294
dgv4911n71 CNV Loss 21882294
nsv436348 CNV Deletion 17901297
esv999560 CNV Deletion 20482838
esv2430597 CNV Loss 19546169
esv22760 CNV Gain+Loss 19812545
esv2593346 CNV Deletion 19546169
nsv512650 CNV Loss 21212237
nsv829105 CNV Loss 20364138
esv2724066 CNV Deletion 23290073
nsv9878 CNV Gain+Loss 18304495
esv2667916 CNV Deletion 23128226
dgv35n47 CNV Loss 21111241
esv6716 CNV Loss 19470904
esv2421686 OTHER Complex 20811451
nsv442792 CNV CNV 18776908
essv6078 CNV CNV 17122850
esv2656467 CNV Deletion 23128226
nsv511643 CNV Loss 21212237
esv2656800 CNV Deletion 23128226
nsv471423 CNV Duplication 19718026
nsv482073 CNV Gain 20164927
dgv751n67 CNV Loss 20364138
nsv914614 CNV Loss 21882294
dgv826e199 CNV Deletion 23128226
nsv829109 CNV Loss 20364138
dgv4912n71 CNV Gain 21882294
nsv914616 CNV Gain 21882294

Relevant External Links for DDTL Gene

HapMap Linkage Disequilibrium report
DDTL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDTL Gene

Disorders for DDTL Gene

Relevant External Links for DDTL

Genetic Association Database (GAD)
DDTL
Human Genome Epidemiology (HuGE) Navigator
DDTL
genes like me logo Genes that share disorders with DDTL: view

No data available for UniProtKB/Swiss-Prot for DDTL Gene

Publications for DDTL Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M. … Board P. (Biochem. J. 1998) 2 3
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for DDTL Gene

Sources for DDTL Gene

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