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Aliases for DDT Gene

Aliases for DDT Gene

  • D-Dopachrome Tautomerase 2 3 4 5
  • Phenylpyruvate Tautomerase II 3 4
  • D-Dopachrome Decarboxylase 2
  • EC 4.1.1.84 4
  • DDCT 3

External Ids for DDT Gene

Previous GeneCards Identifiers for DDT Gene

  • GC22M021009
  • GC22M022638
  • GC22M024313
  • GC22M007261

Summaries for DDT Gene

Entrez Gene Summary for DDT Gene

  • D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDT Gene

DDT (D-Dopachrome Tautomerase) is a Protein Coding gene. GO annotations related to this gene include dopachrome isomerase activity and D-dopachrome decarboxylase activity. An important paralog of this gene is MIF.

UniProtKB/Swiss-Prot for DDT Gene

  • Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).

Gene Wiki entry for DDT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDT Gene

Genomics for DDT Gene

Regulatory Elements for DDT Gene

Enhancers for DDT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDT on UCSC Golden Path with GeneCards custom track

Promoters for DDT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDT on UCSC Golden Path with GeneCards custom track

Genomic Location for DDT Gene

Chromosome:
22
Start:
23,971,365 bp from pter
End:
23,980,469 bp from pter
Size:
9,105 bases
Orientation:
Minus strand

Genomic View for DDT Gene

Genes around DDT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDT Gene

Proteins for DDT Gene

  • Protein details for DDT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30046-DOPD_HUMAN
    Recommended name:
    D-dopachrome decarboxylase
    Protein Accession:
    P30046
    Secondary Accessions:
    • B7Z522
    • O00774
    • O60787
    • Q13534

    Protein attributes for DDT Gene

    Size:
    118 amino acids
    Molecular mass:
    12712 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for DDT Gene

    Alternative splice isoforms for DDT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDT Gene

Proteomics data for DDT Gene at MOPED

Post-translational modifications for DDT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDT Gene

No data available for DME Specific Peptides for DDT Gene

Domains & Families for DDT Gene

Graphical View of Domain Structure for InterPro Entry

P30046

UniProtKB/Swiss-Prot:

DOPD_HUMAN :
  • Belongs to the MIF family.
Family:
  • Belongs to the MIF family.
genes like me logo Genes that share domains with DDT: view

No data available for Gene Families for DDT Gene

Function for DDT Gene

Molecular function for DDT Gene

GENATLAS Biochemistry:
D-dopachrome tautomerase,converting L-dopachrome into dihydroxyindole,highly homolog to and maybe same as MIF,tightly linked to GSTT2,in head to head disposition
UniProtKB/Swiss-Prot CatalyticActivity:
D-dopachrome = 5,6-dihydroxyindole + CO(2).
UniProtKB/Swiss-Prot Function:
Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).

Enzyme Numbers (IUBMB) for DDT Gene

Gene Ontology (GO) - Molecular Function for DDT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033981 D-dopachrome decarboxylase activity IEA --
genes like me logo Genes that share ontologies with DDT: view

Animal Model Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDT Gene

Localization for DDT Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDT Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DDT Gene

Pathways & Interactions for DDT Gene

SuperPathways for DDT Gene

No Data Available

Interacting Proteins for DDT Gene

Gene Ontology (GO) - Biological Process for DDT Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DDT Gene

Drugs & Compounds for DDT Gene

(6) Drugs for DDT Gene - From: ClinicalTrials, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
5,6-Dihydroxyindole Experimental Pharma 0
Androgen Antagonists Pharma 297
Androgens Pharma 1232
Hormone Antagonists Pharma 12130
Hormones Pharma 13269

(4) Additional Compounds for DDT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
D-Dopachrome
  • (2R)-2,3,5,6-tetrahydro-5,6-dioxo-1H-Indole-2-carboxylic acid
203000-17-3
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
124-38-9
genes like me logo Genes that share compounds with DDT: view

Transcripts for DDT Gene

Unigene Clusters for DDT Gene

D-dopachrome tautomerase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDT Gene

No ASD Table

Relevant External Links for DDT Gene

GeneLoc Exon Structure for
DDT
ECgene alternative splicing isoforms for
DDT

Expression for DDT Gene

mRNA expression in normal human tissues for DDT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDT Gene

This gene is overexpressed in Liver (x7.2).

Protein differential expression in normal tissues from HIPED for DDT Gene

This gene is overexpressed in Gallbladder (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDT Gene



SOURCE GeneReport for Unigene cluster for DDT Gene Hs.656723

genes like me logo Genes that share expression patterns with DDT: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DDT Gene

Orthologs for DDT Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDT 35
  • 84.75 (n)
  • 79.66 (a)
DDT 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856501 35
  • 86.44 (n)
  • 83.9 (a)
mouse
(Mus musculus)
Mammalia Ddt 35
  • 77.4 (n)
  • 73.73 (a)
Ddt 16
Ddt 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ddt 35
  • 78.25 (n)
  • 74.58 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia DDT 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDT 35
  • 74.01 (n)
  • 69.49 (a)
DDT 36
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ddt 35
  • 64.97 (n)
  • 64.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23562 35
zebrafish
(Danio rerio)
Actinopterygii ddt 35
  • 56.78 (n)
  • 53.39 (a)
ddt 36
  • 53 (a)
OneToMany
Species with no ortholog for DDT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDT Gene

ENSEMBL:
Gene Tree for DDT (if available)
TreeFam:
Gene Tree for DDT (if available)

Paralogs for DDT Gene

Paralogs for DDT Gene

(2) SIMAP similar genes for DDT Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DDT Gene

genes like me logo Genes that share paralogs with DDT: view

Variants for DDT Gene

Sequence variations from dbSNP and Humsavar for DDT Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs9612529 -- 23,976,413(+) CTGGA(C/G)AAGAG intron-variant, upstream-variant-2KB
rs9624365 -- 23,973,190(+) CCTGT(A/T)TTCAC intron-variant
rs9624366 -- 23,976,812(+) GCTCC(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDT Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
dgv1390e1 CNV Complex 17122850
nsv3578 CNV Loss 18451855
nsv197 CNV Loss 15895083
dgv4909n71 CNV Gain 21882294
nsv469844 CNV Complex 16826518
dgv4910n71 CNV Gain+Loss 21882294
nsv914610 CNV Gain 21882294
dgv4911n71 CNV Loss 21882294
esv2430597 CNV Loss 19546169
esv22760 CNV Gain+Loss 19812545
nsv9878 CNV Gain+Loss 18304495
esv2421686 OTHER Complex 20811451
nsv442792 CNV CNV 18776908
essv6078 CNV CNV 17122850
nsv511643 CNV Loss 21212237
esv2656800 CNV Deletion 23128226
nsv471423 CNV Duplication 19718026
nsv482073 CNV Gain 20164927
dgv751n67 CNV Loss 20364138
nsv914614 CNV Loss 21882294
dgv826e199 CNV Deletion 23128226
nsv829109 CNV Loss 20364138
dgv4912n71 CNV Gain 21882294
nsv914616 CNV Gain 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for DDT Gene

Disorders for DDT Gene

Relevant External Links for DDT

Genetic Association Database (GAD)
DDT
Human Genome Epidemiology (HuGE) Navigator
DDT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDT

No disorders were found for DDT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDT Gene

Publications for DDT Gene

  1. Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. (PMID: 9480844) Nishihira J. … Sakai M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23 67
  2. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M. … Board P. (Biochem. J. 1998) 2 3 23
  3. Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase. (PMID: 18684922) Coleman A.M. … Mitchell R.A. (J. Immunol. 2008) 3 23
  4. UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor. (PMID: 12823441) Sonesson B. … Hansson C. (Exp. Dermatol. 2003) 3 23
  5. Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54-A resolution. (PMID: 10079069) Sugimoto H. … Nishihira J. (Biochemistry 1999) 3 23

Products for DDT Gene

Sources for DDT Gene

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