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DDT Gene

protein-coding   GIFtS: 57
GCID: GC22M024313

D-Dopachrome Tautomerase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
D-Dopachrome Tautomerase1 2 3
D-Dopachrome Decarboxylase1 2
Phenylpyruvate Tautomerase II2 3
DDCT2
EC 4.1.1.843

External Ids:    HGNC: 27321   Entrez Gene: 16522   Ensembl: ENSG000000999777   OMIM: 6027505   UniProtKB: P300463   
ORGUL members:         

Export aliases for DDT gene to outside databases

Previous GC identifers: GC22M021009 GC22M022638 GC22M007261


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDT Gene:
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration
inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked
on chromosome 22. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDT Gene:
DDT (D-dopachrome tautomerase) is a protein-coding gene. Diseases associated with DDT include sinusitis, and prostate cancer. GO annotations related to this gene include D-dopachrome decarboxylase activity and dopachrome isomerase activity. An important paralog of this gene is DDTL.

UniProtKB/Swiss-Prot: DOPD_HUMAN, P30046
Function: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)

Gene Wiki entry for DDT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NT_187633.1  NC_000022.11  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDT gene promoter:
         p53   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDT promoter sequence
   Search Chromatin IP Primers for DDT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

DDT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDT gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M024313:  view genomic region     (about GC identifiers)

Start:
24,313,554 bp from pter      End:
24,322,660 bp from pter
Size:
9,107 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DOPD_HUMAN, P30046 (See protein sequence)
Recommended Name: D-dopachrome decarboxylase  
Size: 118 amino acids; 12712 Da
Subunit: Homotrimer
2 PDB 3D structures from and Proteopedia for DDT:
1DPT (3D)        3KAN (3D)    
Secondary accessions: O00774 O60787 Q13534

Explore the universe of human proteins at neXtProt for DDT: NX_P30046

Explore proteomics data for DDT at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21
  • Modification sites at PhosphoSitePlus

  • See DDT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001077861.1  NP_001346.1  

    ENSEMBL proteins: 
     ENSP00000381386   ENSP00000215773   ENSP00000409440   ENSP00000385714   ENSP00000384866  
     ENSP00000399768  

    DDT Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014347 Tautomerase/MIF_sf
     IPR001398 Macrophage_inhib_fac
     IPR019829 Macrophage_inhib_fac_CS

    Graphical View of Domain Structure for InterPro Entry P30046

    ProtoNet protein and cluster: P30046

    1 Blocks protein domain: IPB001398 Macrophage migration inhibitory factor

    UniProtKB/Swiss-Prot: DOPD_HUMAN, P30046
    Similarity: Belongs to the MIF family


    DDT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DOPD_HUMAN, P30046
    Function: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)
    Catalytic activity: D-dopachrome = 5,6-dihydroxyindole + CO(2)

         Genatlas biochemistry entry for DDT:
    D-dopachrome tautomerase,converting L-dopachrome into dihydroxyindole,highly homolog to and maybe same as
    MIF,tightly linked to GSTT2,in head to head disposition

         Enzyme Number (IUBMB): EC 4.1.1.841

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004167dopachrome isomerase activity TAS9480844
    GO:0033981D-dopachrome decarboxylase activity IEA--
         
    DDT for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDT
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    miRNA
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    miRTarBase miRNAs that target DDT:
    hsa-mir-149-5p (MIRT045554), hsa-mir-1226-3p (MIRT036520), hsa-mir-92b-5p (MIRT037798), hsa-mir-1 (MIRT024080)

    Block miRNA regulation of human, mouse, rat DDT using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate DDT:
    hsa-miR-320e hsa-miR-330-5p hsa-miR-326 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidDDT 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DOPD_HUMAN, P30046: Cytoplasm (By similarity)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    DDT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDT
    Interactions:

        Search GeneGlobe Interaction Network for DDT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for DDT (P300463 ENSP000002157734) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DSTYKQ6XUX33, ENSP000003561304I2D: score=2 STRING: ENSP00000356130
    ATG5Q9H1Y03I2D: score=1 
    DDIT3P356383I2D: score=1 
    EIF1BO607393I2D: score=1 
    HLA-BP304803I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042438melanin biosynthetic process IEA--

    DDT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDT (DOPD)

    3 HMDB Compounds for DDT    About this table
    CompoundSynonyms CAS #PubMed Ids
    5,6-DihydroxyindoleDHI;dopaminochrome (see all 2)3131-52-0--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    D-Dopachrome(2R)-2,3,5,6-tetrahydro-5,6-dioxo-1H-Indole-2-carboxylic acid (see all 2)203000-17-3--

    4 Novoseek inferred chemical compound relationships for DDT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    d-dopachrome 99.4 47 10079069 (6), 9480844 (5), 7589466 (5), 9356298 (4) (see all 19)
    5-carboxymethyl-2-hydroxymuconate 95.5 2 9854138 (1), 12382291 (1)
    5,6-dihydroxyindole 92.9 4 9480844 (2), 8267597 (1), 9356298 (1)
    4-oxalocrotonate 84.7 1 12382291 (1)



    DDT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DDT gene (2 alternative transcripts): 
    NM_001084392.1  NM_001355.3  

    Unigene Cluster for DDT:

    D-dopachrome tautomerase
    Hs.656723  [show with all ESTs]
    Unigene Representative Sequence: AK126983
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398344(uc002zyz.4) ENST00000350608(uc002zza.4) ENST00000428792
    ENST00000404092 ENST00000444947(uc011ajj.2) ENST00000403754 ENST00000430101

    miRNA
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    4 qRT-PCR Assays for microRNAs that regulate DDT:
    hsa-miR-320e hsa-miR-330-5p hsa-miR-326 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidDDT 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDT
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    GenScript: all cDNA clones in your preferred vector (see all 2): DDT (NM_001355)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDT
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    OriGene qPCR primer pairs and template standards for DDT
    OriGene qSTAR qPCR primer pairs in human, mouse for DDT
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DDT
      QuantiTect SYBR Green Assays in human, mouse, rat DDT
      QuantiFast Probe-based Assays in human, mouse, rat DDT

    Additional mRNA sequence: 

    AK126983.1 AK292044.1 BC005971.1 BC015508.2 BT006970.1 CR456431.1 U49785.1 U84143.1 

    17 DOTS entries:

    DT.100793425  DT.100750927  DT.449123  DT.100679657  DT.100750896  DT.40265255  DT.91973351  DT.92456387 
    DT.120669486  DT.92456395  DT.100793421  DT.100793422  DT.120669487  DT.92434909  DT.92456374  DT.95211074 
    DT.95308228 

    Selected AceView cDNA sequences (see all 289):

    AV661233 BU753620 AA641797 CB127169 BM709356 AA876330 AI304569 AI816115 
    CD676257 BQ643878 BU732732 AI857553 BE703692 BM676255 CB159751 BE467297 
    BQ650744 BM712255 BE703645 BM924587 BQ070856 AV655183 BM701143 BE703796 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAACATTCCT
    DDT Expression
    About this image


    DDT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Kidney (Urinary System)
             Metanephros
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
     
     Colon (Gastrointestinal Tract)
     
     Adipose (Muscoskeletal System)
     
     Liver (Hepatobiliary System)
    DDT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656723
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DDT gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddt1 , 5 D-dopachrome tautomerase1, 5 77.4(n)1
    73.73(a)1
      10 (38.58 cM)5
    132021  NM_010027.11  NP_034157.11 
     757712305 
    chicken
    (Gallus gallus)
    Aves DDT1 D-dopachrome tautomerase 74.01(n)
    69.49(a)
      416937  NM_001030667.1  NP_001025838.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    60(a)
    1 → many
    GL343417.1(30352-31182)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.235622 Xenopus laevis, Similar to D-dopachrome tautomerase, more 70.97(n)    BC043871.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ddt1 D-dopachrome tautomerase 56.78(n)
    53.39(a)
      415237  NM_001002147.1  NP_001002147.1 


    ENSEMBL Gene Tree for DDT (if available)
    TreeFam Gene Tree for DDT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDT gene
    DDTL2  
    2 SIMAP similar genes for DDT using alignment to 6 protein entries:     DOPD_HUMAN (see all proteins):
    DDTL    MIF

    DDT for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for DDT
    PGOHUM00000259720 PGOHUM00000246535 PGOHUM00000237591


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDT (see all 30)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21863681,2
    C--8270214(-) GGTCAG/TAAGGA 2 -- int10--------
    rs21546021,2
    C--8270473(-) CATCAA/GGGTCT 2 -- int10--------
    rs6788631,2
    F--8276268(-) GCCGCA/GGGAGG 1 -- int11Minor allele frequency- G:0.09MN 184
    rs1401851,2
    C--8276393(+) TCCTTA/GACCCC 1 -- int13Minor allele frequency- G:0.45EA MN NA 1486
    rs725546671,2
    F--8276481(-) ATCCCT/CTAAAA 1 -- int15Minor allele frequency- C:0.40MN 404
    rs1401861,2
    C,F--8276482(+) TTTAGA/GGGATC 1 -- int17Minor allele frequency- C:0.01EA NA MN 1820
    rs725523781,2
    F--8276570(-) GAAAGT/CCCCCA 2 -- ut515Minor allele frequency- C:0.47MN 392
    rs2017285291,2
    --8277175(-) CTGGGA/GGTGCA 1 -- us2k10--------
    rs22670471,2
    C,F--8277336(+) GATAAC/TGTTAC 1 -- us2k11Minor allele frequency- T:0.33EA 1498
    rs96243691,2
    ----8276742(+) GAGGGC/TCCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDT (24313554 - 24322660 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DDT (see all 32):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724041CNV Deletion23290073
    esv2656800CNV Deletion23128226
    dgv826e199CNV Deletion23128226
    nsv471423CNV Duplication19718026
    nsv914614CNV Loss21882294
    dgv751n67CNV Loss20364138
    nsv511643CNV Loss21212237
    nsv197CNV Loss15895083
    nsv829109CNV Loss20364138
    dgv4911n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602750    OMIM disorders: --

    3 diseases for DDT:    
    About MalaCards
    sinusitis    prostate cancer    prostatitis


    DDT for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for DDT gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 4 12823441 (3), 10079069 (1)

    Genetic Association Database (GAD): DDT
    Human Genome Epidemiology (HuGE) Navigator: DDT (11 documents)

    Export disorders for DDT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDT gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with DDT)
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    1. Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. (PubMed id 9480844)1, 2, 3, 9 Nishihira J.... Sakai M. (Biochem. Biophys. Res. Commun. 1998)
    2. Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF. (PubMed id 9716662)1, 2, 9 Esumi N....Wistow G. (Mamm. Genome 1998)
    3. Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54-A resolution. (PubMed id 10079069)1, 2, 9 Sugimoto H....Nishihira J. (Biochemistry 1999)
    4. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PubMed id 9729470)1, 3, 9 Coggan M....Board P. (Biochem. J. 1998)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    10. Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)1, 2 Hochstrasser D.F.... Hughes G.J. (Electrophoresis 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1652 HGNC: 2732 AceView: DDT Ensembl:ENSG00000099977 euGenes: HUgn1652
    ECgene: DDT H-InvDB: DDT

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDT Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDT Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDT gene:
    Search GeneIP for patents involving DDT

    GeneCards and IP:
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