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Aliases for DDT Gene

Aliases for DDT Gene

  • D-Dopachrome Tautomerase 2 3 4
  • Phenylpyruvate Tautomerase II 3 4
  • D-Dopachrome Decarboxylase 2 3
  • EC 4.1.1.84 4
  • DDCT 3

External Ids for DDT Gene

Summaries for DDT Gene

Entrez Gene Summary for DDT Gene

  • D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDT Gene

DDT (D-Dopachrome Tautomerase) is a Protein Coding gene. GO annotations related to this gene include dopachrome isomerase activity and D-dopachrome decarboxylase activity. An important paralog of this gene is DDTL.

UniProtKB/Swiss-Prot for DDT Gene

  • Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)

Gene Wiki entry for DDT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDT Gene

Genomics for DDT Gene

Genomic Location for DDT Gene

Start:
23,971,365 bp from pter
End:
23,980,469 bp from pter
Size:
9,105 bases
Orientation:
Minus strand

Genomic View for DDT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDT Gene

Regulatory Elements for DDT Gene

Proteins for DDT Gene

  • Protein details for DDT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30046-DOPD_HUMAN
    Recommended name:
    D-dopachrome decarboxylase
    Protein Accession:
    P30046
    Secondary Accessions:
    • B7Z522
    • O00774
    • O60787
    • Q13534

    Protein attributes for DDT Gene

    Size:
    118 amino acids
    Molecular mass:
    12712 Da
    Quaternary structure:
    • Homotrimer.

    Three dimensional structures from OCA and Proteopedia for DDT Gene

    Alternative splice isoforms for DDT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDT Gene

Proteomics data for DDT Gene at MOPED

Post-translational modifications for DDT Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21

Other Protein References for DDT Gene

No data available for DME Specific Peptides for DDT Gene

Domains for DDT Gene

UniProtKB/Swiss-Prot:

DOPD_HUMAN
Family:
  • Belongs to the MIF family.:
    • P30046
genes like me logo Genes that share domains with DDT: view

No data available for Gene Families for DDT Gene

Function for DDT Gene

Molecular function for DDT Gene

GENATLAS Biochemistry: D-dopachrome tautomerase,converting L-dopachrome into dihydroxyindole,highly homolog to and maybe same as MIF,tightly linked to GSTT2,in head to head disposition
UniProtKB/Swiss-Prot CatalyticActivity: D-dopachrome = 5,6-dihydroxyindole + CO(2)
UniProtKB/Swiss-Prot Function: Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)

Enzyme Numbers (IUBMB) for DDT Gene

Gene Ontology (GO) - Molecular Function for DDT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004167 dopachrome isomerase activity TAS 9480844
GO:0033981 D-dopachrome decarboxylase activity IEA --
genes like me logo Genes that share ontologies with DDT: view

miRNA for DDT Gene

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DDT Gene

Localization for DDT Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDT Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for DDT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DDT: view

Pathways for DDT Gene

SuperPathways for DDT Gene

No Data Available

Interacting Proteins for DDT Gene

Gene Ontology (GO) - Biological Process for DDT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042438 melanin biosynthetic process IEA --
genes like me logo Genes that share ontologies with DDT: view

No data available for Pathways by source for DDT Gene

Compounds for DDT Gene

(3) HMDB Compounds for DDT Gene

Compound Synonyms Cas Number PubMed IDs
5,6-Dihydroxyindole
  • DHI
3131-52-0
Carbon dioxide
  • Carbon oxide
124-38-9
D-Dopachrome
  • (2R)-2,3,5,6-tetrahydro-5,6-dioxo-1H-Indole-2-carboxylic acid
203000-17-3

(4) Novoseek inferred chemical compound relationships for DDT Gene

Compound -log(P) Hits PubMed IDs
d-dopachrome 99.4 39
5-carboxymethyl-2-hydroxymuconate 95.5 2
5,6-dihydroxyindole 92.9 4
4-oxalocrotonate 84.7 1
genes like me logo Genes that share compounds with DDT: view

Transcripts for DDT Gene

Unigene Clusters for DDT Gene

D-dopachrome tautomerase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDT Gene

No ASD Table

Relevant External Links for DDT Gene

GeneLoc Exon Structure for
DDT
ECgene alternative splicing isoforms for
DDT

Expression for DDT Gene

mRNA expression in normal human tissues for DDT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDT Gene

This gene is overexpressed in Liver (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDT Gene

SOURCE GeneReport for Unigene cluster for DDT Gene Hs.656723

genes like me logo Genes that share expressions with DDT: view

Orthologs for DDT Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDT 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDT 36
  • 84.75 (n)
  • 79.66 (a)
DDT 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100856501 36
  • 86.44 (n)
  • 83.9 (a)
mouse
(Mus musculus)
Mammalia Ddt 36
  • 77.4 (n)
  • 73.73 (a)
Ddt 16
Ddt 37
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 65 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ddt 36
  • 78.25 (n)
  • 74.58 (a)
chicken
(Gallus gallus)
Aves DDT 36
  • 74.01 (n)
  • 69.49 (a)
DDT 37
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 60 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.23562 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ddt 36
  • 64.97 (n)
  • 64.41 (a)
zebrafish
(Danio rerio)
Actinopterygii ddt 36
  • 56.78 (n)
  • 53.39 (a)
ddt 37
  • 53 (a)
OneToMany
Species with no ortholog for DDT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDT Gene

ENSEMBL:
Gene Tree for DDT (if available)
TreeFam:
Gene Tree for DDT (if available)

Paralogs for DDT Gene

Paralogs for DDT Gene

Selected SIMAP similar genes for DDT Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for DDT Gene

genes like me logo Genes that share paralogs with DDT: view

Variants for DDT Gene

Sequence variations from dbSNP and Humsavar for DDT Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs9612529 -- 23,976,413(+) CTGGA(C/G)AAGAG upstream-variant-2KB, intron-variant
rs9624365 -- 23,973,190(+) CCTGT(A/T)TTCAC intron-variant
rs9624366 -- 23,976,812(+) GCTCC(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDT Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
nsv834155 CNV Gain+Loss 17160897
nsv914605 CNV Gain 21882294
dgv1390e1 CNV Complex 17122850
nsv3578 CNV Loss 18451855
nsv197 CNV Loss 15895083
dgv4909n71 CNV Gain 21882294
nsv469844 CNV Complex 16826518
dgv4910n71 CNV Gain+Loss 21882294
nsv914610 CNV Gain 21882294
dgv4911n71 CNV Loss 21882294
esv2430597 CNV Loss 19546169
esv22760 CNV Gain+Loss 19812545
nsv9878 CNV Gain+Loss 18304495
esv2421686 OTHER Complex 20811451
nsv442792 CNV CNV 18776908
essv6078 CNV CNV 17122850
nsv511643 CNV Loss 21212237
esv2656800 CNV Deletion 23128226
nsv471423 CNV Duplication 19718026
nsv482073 CNV Gain 20164927
dgv751n67 CNV Loss 20364138
nsv914614 CNV Loss 21882294
dgv826e199 CNV Deletion 23128226
nsv829109 CNV Loss 20364138
dgv4912n71 CNV Gain 21882294
nsv914616 CNV Gain 21882294

Relevant External Links for DDT Gene

HapMap Linkage Disequilibrium report
DDT

Disorders for DDT Gene

(1) Novoseek inferred disease relationships for DDT Gene

Disease -log(P) Hits PubMed IDs
inflammation 0 4

Relevant External Links for DDT

Genetic Association Database (GAD)
DDT
Human Genome Epidemiology (HuGE) Navigator
DDT
genes like me logo Genes that share disorders with DDT: view

No data available for UniProtKB/Swiss-Prot for DDT Gene

Publications for DDT Gene

  1. Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. (PMID: 9480844) Nishihira J. … Sakai M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 23
  2. Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF. (PMID: 9716662) Esumi N. … Wistow G. (Mamm. Genome 1998) 3 4 23
  3. Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PMID: 9729470) Coggan M. … Board P. (Biochem. J. 1998) 2 3 23
  4. Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54-A resolution. (PMID: 10079069) Sugimoto H. … Nishihira J. (Biochemistry 1999) 3 4 23
  5. UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor. (PMID: 12823441) Sonesson B. … Hansson C. (Exp. Dermatol. 2003) 3 23

Products for DDT Gene

Sources for DDT Gene

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