DDT Gene
protein-coding GIFtS : 54
GCID: GC22 M024313
D-dopachrome tautomerase
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Aliasesfor DDT gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases D-Dopachrome Tautomerase 1 2 3 DDCT1 2 Phenylpyruvate Tautomerase II2 3 D-Dopachrome Decarboxylase2 EC 4.1.1.843
Export aliases for DDT gene to outside databases Previous GC identifers: GC22M021009 GC22M022638 GC22M007261
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Summariesfor DDT gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DDT : D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: DOPD_HUMAN, P30046 Function : Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)Gene Wiki entry for DDT
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Genomic Viewsfor DDT gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000022.10 NC_018933.1 NT_011520.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DDT gene promoter: p53 AP-1 ATF-2 c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for DDT Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDT
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23 DDT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22M024313: view genomic region
(about GC identifiers )
Start:
24,313,554 bp from pter
End:
24,322,660 bp from pter
Size:
9,107 bases
Orientation:
minus strand
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Proteinsfor DDT gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DOPD_HUMAN, P30046 (See
protein sequence )Recommended Name: D-dopachrome decarboxylase Size : 118 amino acids; 12712 Da
Subunit : Homotrimer
Subcellular location : Cytoplasm (By similarity)
2 PDB 3D structures from and Proteopedia for DDT :1DPT (3D)
  3KAN (3D)
 
Secondary accessions : O00774 O60787 Q13534Explore the universe of human proteins at neXtProt for DDT: NX_P30046 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P30046 DDT Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (2 alternative transcripts):
NP_001077861.1 NP_001346.1 ENSEMBL proteins: ENSP00000381386 ENSP00000215773 ENSP00000409440 ENSP00000385714 ENSP00000384866 ENSP00000399768 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
DDT for ontologies About GeneDecksing DDT Antibody Products: Assay Products for DDT:
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Protein
Domains / Familiesfor DDT gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DDT for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P30046 ProtoNet protein and cluster: P30046
1 Blocks protein family : IPB001398 Macrophage migration inhibitory factor UniProtKB/Swiss-Prot: DOPD_HUMAN, P30046 Similarity : Belongs to the MIF family
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Functionfor DDT gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DOPD_HUMAN, P30046 Function : Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)Catalytic activity : D-dopachrome = 5,6-dihydroxyindole + CO(2)
Genatlas biochemistry entry for DDT : D-dopachrome tautomerase,converting L-dopachrome into dihydroxyindole,highly homolog to and maybe same as MIF,tightly linked to GSTT2,in head to head disposition Enzyme Number (IUBMB): EC 4.1.1.84 1 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDT (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDT (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): DDT (NM_001355 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDT Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDT
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004167 dopachrome isomerase activity
TAS 9480844 GO:0033981 D-dopachrome decarboxylase activity
IEA --
DDT for ontologies About GeneDecksing
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Pathways & Interactionsfor DDT gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDT STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)5/11 Interacting proteins for DDT (P30046 3 ENSP00000215773 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 11 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0042438 melanin biosynthetic process
IEA --
DDT for ontologies About GeneDecksing
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Drugs & Compoundsfor DDT gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
DDT for compounds About GeneDecksing Browse Tocris compounds for DDT 3 HMDB Compounds for DDT About this table 4 Novoseek chemical compound relationships for DDT gene About this table
Search CenterWatch for drugs/clinical trials and news about DDT / DOPD
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Transcriptsfor DDT gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DDT gene (2 alternative transcripts): NM_001084392.1 NM_001355.3 Unigene Cluster for DDT:
D-dopachrome tautomerase Hs.656723 [show with all ESTs ] Unigene Representative Sequence: AK126983 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000398344 (uc002zyz.4 ) ENST00000350608 (uc002zza.4 ) ENST00000428792 ENST00000404092 ENST00000444947 (uc011ajj.2 ) ENST00000403754 ENST00000430101 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDT (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDT (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): DDT (NM_001355 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDT Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDT
Additional cDNA sequence: AK126983.1 AK292044.1 BC005971.1 BC015508.2 BT006970.1 CR456431.1 U49785.1 U84143.1
17 DOTS entries : DT.100793425 DT.100750927
DT.449123 DT.100679657 DT.100750896 DT.40265255 DT.91973351 DT.92456387 DT.120669486 DT.92456395 DT.100793421 DT.100793422 DT.120669487 DT.92434909 DT.92456374 DT.95211074 DT.95308228 24/289 AceView cDNA sequences (see all 289 ):
BE703692 BM835780 BE703683 CB127169 BQ650744 AA397824 BU753620 BM676255 BM712255 CB159751 BE703645 AI738576 BE467297 AA044388 BC015508 AA876330 BM986827 BI963061 BM709356 AI304569 BU732732 BQ025939 AI816115 AA641797 GeneLoc Exon Structure
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Expression for DDT gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DDT expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CAACATTCCT
About this image DDT expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 2 LifeMap In Vivo Development Anatomical Compartments/Cells Tissue Anatomical Compartment
Cell Category (developmental path) Kidney Metanephros Kidney Reproductive System Mesonephros Reproductive System Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See DDT Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DDT SOURCE GeneReport for Unigene cluster: Hs.656723 SABiosciences Custom PCR Arrays for DDT Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DDTBrowse OriGene validated miRNA SYBR primer pairs Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat DDT QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DDT QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DDT
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Orthologsfor DDT gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for DDT gene from 5/12 species (see all 12 ) About this table
ENSEMBL Gene Tree for DDT (if available)TreeFam Gene Tree for DDT (if available)
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Paralogsfor DDT gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DDT gene MIF 2 DDTL 2 2 SIMAP similar genes for DDT using alignment to 6 protein entries: DOPD_HUMAN (see all proteins ):DDTL MIF
DDT for paralogs About GeneDecksing 3 Pseudogenes.org Pseudogenes for DDT PGOHUM00000259720 PGOHUM00000246535 PGOHUM00000237591
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Genomic Variantsfor DDT gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 22 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DDT (24313554 - 24322660 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 11 variations for DDT 11 CNVs : 67856 36014 73792 3238 36013 0548 36012 32452 73786 73794 38793
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DDT
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Disorders
/ Diseasesfor DDT gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DDT for disorders About GeneDecksing
OMIM gene information: 602750
OMIM disorders : --5 diseases for DDT : About MalaCards non-small cell lung carcinoma lung carcinoma prostate cancer carcinoma prostatitis 1 Novoseek disease relationship for DDT gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation
0
4
12823441 (3), 10079069 (1)
Human Genome Epidemiology (HuGE) Navigator: DDT (11 documents) Export disorders for DDT gene to outside databases
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Publicationsfor DDT gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DDT gene, integrated from 9 sources (see all 37 ): (articles sorted by number of sources associating them with DDT) Utopia : connect your pdf to the dynamic world of online information
Molecular cloning of human D-dopachrome tautomerase cDNA: N-terminal proline is essential for enzyme activation. (PubMed id 9480844) 1 , 2 , 3, 9 Nishihira J.... Sakai M. (1998) Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF. (PubMed id 9716662) 1 , 2 , 9 Esumi N....Wistow G. (1998) Crystal structure of human D-dopachrome tautomerase, a homologue of macrophage migration inhibitory factor, at 1.54-A resolution. (PubMed id 10079069) 1 , 2 , 9 Sugimoto H....Nishihira J. (1999) Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex. (PubMed id 9729470) 1 , 3, 9 Coggan M....Board P. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802) 1 , 2 Collins J.E.... Dunham I. (2004) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801) 1 , 2 Gevaert K.... Vandekerckhove J. (2003) The DNA sequence of human chromosome 22. (PubMed id 10591208) 1 , 2 Dunham I....O'Brien K.P. (1999) Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669) 1 , 2 Hochstrasser D.F.... Hughes G.J. (1992) UVB-induced inflammation gives increased d-dopachrome tautomerase activity in blister fluid which correlates with macrophage migration inhibitory factor. (PubMed id 12823441) 1 , 9 Sonesson B....Hansson C. (2003)
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External Searches for DDT gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DDT gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DDT gene
(According to HUGE )
About This Section --
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Specialized Databases showing DDT gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for DDT gene: Search GeneIP for patents involving DDT GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DDT gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for DDT OriGene shRNA RFP for DDT OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DDT OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DDT OriGene Protein Over-expression Lysate for DDT Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DDT OriGene 3'-UTR Clone for DDT OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDT OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDT Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for DDT OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DDT OriGene Custom Protein Services for DDT OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDT QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DDT QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDT QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DDT QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DDT QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DDT
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Recombinant Protein for DDT
DDT Proteins, Antibodies, CLIAs, and ELISAs
ThermoFisher Antibodies for DDT
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDT
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Aliases for DDT
Databases for DDT
Disorders / Diseases for DDT
Domains / Families for DDT
Drugs / Compounds for DDT
Expression for DDT
Function for DDT
Genomic Views for DDT
Intellectual Property for DDT
Orthologs for DDT
Paralogs for DDT
Pathways / Interactions for DDT
Products for DDT
Proteins for DDT
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Transcripts for DDT
Variants for DDT
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