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Aliases for DDRGK1 Gene

Aliases for DDRGK1 Gene

  • DDRGK Domain Containing 1 2 3
  • UFM1-Binding And PCI Domain-Containing Protein 1 3 4
  • C20orf116 3 4
  • Dashurin 2 3
  • UFBP1 3 4
  • UFM1-Binding Protein 1 Containing A PCI Domain 3
  • Chromosome 20 Open Reading Frame 116 2
  • DDRGK Domain-Containing Protein 1 3
  • DJ1187M17.3 3

External Ids for DDRGK1 Gene

Previous Symbols for DDRGK1 Gene

  • C20orf116

Summaries for DDRGK1 Gene

GeneCards Summary for DDRGK1 Gene

DDRGK1 (DDRGK Domain Containing 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DDRGK1 Gene

  • Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIB, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDRGK1 Gene

Genomics for DDRGK1 Gene

Genomic Location for DDRGK1 Gene

Start:
3,190,350 bp from pter
End:
3,204,685 bp from pter
Size:
14,336 bases
Orientation:
Minus strand

Genomic View for DDRGK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDRGK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDRGK1 Gene

Regulatory Elements for DDRGK1 Gene

Proteins for DDRGK1 Gene

  • Protein details for DDRGK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HY6-DDRGK_HUMAN
    Recommended name:
    DDRGK domain-containing protein 1
    Protein Accession:
    Q96HY6
    Secondary Accessions:
    • A6NIU5
    • C9JSZ5
    • Q9BW47

    Protein attributes for DDRGK1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35611 Da
    Quaternary structure:
    • Interacts with TRIP4; the interaction with TRIP4 is direct (PubMed:25219498). Interacts with UFL1 (PubMed:25219498). Interacts with NFKBIB (PubMed:23675531). Interacts with CDK5RAP3 (PubMed:20228063).

    Alternative splice isoforms for DDRGK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDRGK1 Gene

Proteomics data for DDRGK1 Gene at MOPED

Post-translational modifications for DDRGK1 Gene

  • Ubiquitinated. Ubiquitination probably triggers proteasomal degradation and is negatively regulated by UFL1, the enzyme involved in the ufmylation of DDRGK1.
  • Ufmylated. Conjugated to ubiquitin-like protein UFM1, probably at Lys-267 by UFL1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys227

Other Protein References for DDRGK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDRGK1 Gene

Domains for DDRGK1 Gene

Protein Domains for DDRGK1 Gene

UniProtKB/Swiss-Prot:

DDRGK_HUMAN
Domain:
  • Contains 1 PCI domain.:
    • Q96HY6
Family:
  • Belongs to the DDRGK1 family.:
    • Q96HY6
genes like me logo Genes that share domains with DDRGK1: view

No data available for Gene Families for DDRGK1 Gene

Function for DDRGK1 Gene

Molecular function for DDRGK1 Gene

UniProtKB/Swiss-Prot Function: Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIB, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity).

Gene Ontology (GO) - Molecular Function for DDRGK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20018847
GO:0044389 ubiquitin-like protein ligase binding IPI 25219498
genes like me logo Genes that share ontologies with DDRGK1: view

miRNA for DDRGK1 Gene

miRTarBase miRNAs that target DDRGK1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DDRGK1 Gene

Localization for DDRGK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDRGK1 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDRGK1 Gene COMPARTMENTS Subcellular localization image for DDRGK1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DDRGK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 20018847
GO:0005789 endoplasmic reticulum membrane IDA 20228063
genes like me logo Genes that share ontologies with DDRGK1: view

Pathways for DDRGK1 Gene

SuperPathways for DDRGK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDRGK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033146 regulation of intracellular estrogen receptor signaling pathway IDA 25219498
GO:0034976 response to endoplasmic reticulum stress ISS --
GO:0051092 positive regulation of NF-kappaB transcription factor activity IMP 23675531
GO:1901800 positive regulation of proteasomal protein catabolic process IMP 23675531
GO:1903721 positive regulation of I-kappaB phosphorylation IMP 23675531
genes like me logo Genes that share ontologies with DDRGK1: view

No data available for Pathways by source for DDRGK1 Gene

Compounds for DDRGK1 Gene

(1) PharmGKB related drug/compound annotations for DDRGK1 Gene

Drug/compound Annotation
azathioprine CA
genes like me logo Genes that share compounds with DDRGK1: view

Transcripts for DDRGK1 Gene

mRNA/cDNA for DDRGK1 Gene

Unigene Clusters for DDRGK1 Gene

DDRGK domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDRGK1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for DDRGK1 Gene

GeneLoc Exon Structure for
DDRGK1
ECgene alternative splicing isoforms for
DDRGK1

Expression for DDRGK1 Gene

mRNA expression in normal human tissues for DDRGK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDRGK1 Gene

SOURCE GeneReport for Unigene cluster for DDRGK1 Gene Hs.471975

mRNA Expression by UniProt/SwissProt for DDRGK1 Gene

Q96HY6-DDRGK_HUMAN
Tissue specificity: Ubiquitously expressed (at protein level).
genes like me logo Genes that share expressions with DDRGK1: view

Orthologs for DDRGK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDRGK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDRGK1 36
  • 99.47 (n)
  • 99.36 (a)
DDRGK1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDRGK1 36
  • 89.1 (n)
  • 91.67 (a)
DDRGK1 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDRGK1 36
  • 87.69 (n)
  • 90.13 (a)
DDRGK1 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddrgk1 36
  • 85.24 (n)
  • 84.39 (a)
Ddrgk1 16
Ddrgk1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDRGK1 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDRGK1 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddrgk1 36
  • 85.9 (n)
  • 85.9 (a)
chicken
(Gallus gallus)
Aves DDRGK1 36
  • 67.36 (n)
  • 66.9 (a)
DDRGK1 37
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDRGK1 37
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4129 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485538 36
  • 70.15 (n)
  • 73.64 (a)
zebrafish
(Danio rerio)
Actinopterygii ddrgk1 36
  • 61.54 (n)
  • 59.44 (a)
ddrgk1 37
  • 25 (a)
OneToOne
zgc56488 36
fruit fly
(Drosophila melanogaster)
Insecta CG5862 37
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ufbp-1 37
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToOne
Species with no ortholog for DDRGK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDRGK1 Gene

ENSEMBL:
Gene Tree for DDRGK1 (if available)
TreeFam:
Gene Tree for DDRGK1 (if available)

Paralogs for DDRGK1 Gene

No data available for Paralogs for DDRGK1 Gene

Variants for DDRGK1 Gene

Sequence variations from dbSNP and Humsavar for DDRGK1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs11591 - 3,190,691(-) TCATC(A/G)CCTGG missense, reference
rs731281 -- 3,202,789(+) TATGG(A/G)GGCCT intron-variant
rs731282 -- 3,202,758(+) GAGGG(C/T)TCTCC intron-variant
rs1046644 -- 3,190,584(-) TCCCC(A/C)CCATC utr-variant-3-prime
rs2295546 -- 3,190,982(+) ATCAG(A/G)CTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDRGK1 Gene

Variant ID Type Subtype PubMed ID
nsv833898 CNV Gain+Loss 17160897
nsv912604 CNV Loss 21882294
nsv528355 CNV Loss 19592680
dgv4519n71 CNV Loss 21882294
dgv4520n71 CNV Loss 21882294

Relevant External Links for DDRGK1 Gene

HapMap Linkage Disequilibrium report
DDRGK1

Disorders for DDRGK1 Gene

Relevant External Links for DDRGK1

Genetic Association Database (GAD)
DDRGK1
genes like me logo Genes that share disorders with DDRGK1: view

No data available for UniProtKB/Swiss-Prot for DDRGK1 Gene

Publications for DDRGK1 Gene

  1. A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. (PMID: 20228063) Wu J. … Li H. (J. Biol. Chem. 2010) 2 3 4
  2. A novel type of E3 ligase for the Ufm1 conjugation system. (PMID: 20018847) Tatsumi K. … Komatsu M. (J. Biol. Chem. 2010) 3 4
  3. Cloning and molecular characterization of Dashurin encoded by C20orf116, a PCI-domain containing protein. (PMID: 20036718) Neziri D. … Wagner L. (Biochim. Biophys. Acta 2010) 2 3
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DDRGK1 Gene

Sources for DDRGK1 Gene

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