Aliases for DDRGK1 Gene
External Ids for DDRGK1 Gene
Previous HGNC Symbols for DDRGK1 Gene
Previous GeneCards Identifiers for DDRGK1 Gene
The protein encoded by this gene interacts with components of the ubiquitin fold modifier 1 conjugation pathway and helps prevent apoptosis in ER-stressed secretory tissues. In addition, the encoded protein regulates nuclear factor-κB activity. [provided by RefSeq, Dec 2015]
GeneCards Summary for DDRGK1 Gene
DDRGK1 (DDRGK Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-like protein ligase binding.
UniProtKB/Swiss-Prot for DDRGK1 Gene
Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIB, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity).