DDRGK1 Gene
protein-coding GIFtS: 45
GCID: GC20M003170
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DDRGK domain containing 1(Previous name: chromosome 20 open reading frame 116 )
(Previous symbol: C20orf116)
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Aliases
for DDRGK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DDRGK Domain Containing 11 2 | | Dashurin2 | | C20orf1161 2 3 | | UFBP12 | | DJ1187M17.31 | | DDRGK Domain-Containing Protein 12 | | Chromosome 20 Open Reading Frame 1161 | | UFM1-Binding Protein 1 Containing A PCI Domain2 |
Export aliases for DDRGK1 gene to outside databasesPrevious GC identifers: GC20M003120 GC20M003121 GC20M003122 |
Summaries
for DDRGK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DDRGK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDRGK1 gene promoter:
RFX1 Spz1 ISGF-3 Sp1 Pbx1a LUN-1 c-Ets-1 Ik-2 CP2 Sox9
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDRGK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDRGK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13DDRGK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M003170: view genomic region
(about GC identifiers)
Start:
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3,170,996 bp from pter |
End:
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3,185,331 bp from pter |
Size:
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14,336 bases |
Orientation:
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minus strand |
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Proteins
for DDRGK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDRGK_HUMAN, Q96HY6 (See
protein sequence)Recommended Name: DDRGK domain-containing protein 1 precursor Size: 314 amino acids; 35611 Da
Subcellular location: Endoplasmic reticulum
Secondary accessions: A6NIU5 C9JSZ5 Q9BW47Alternative splicing: 2 isoforms: Q96HY6-1 Q96HY6-2 Explore the universe of human proteins at neXtProt for DDRGK1: NX_Q96HY6
Post-translational modifications:
Ufmylated. Conjugated to ubiquitin-like protein UFM1, probably at Lys-267. The role of ufmylation is unclear1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96HY6
DDRGK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076424.1
ENSEMBL proteins: ENSP00000346483 ENSP00000369548
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
IDA | -- |
DDRGK1 for ontologies About GeneDecksing
DDRGK1 Antibody Products:
Assay Products for DDRGK1: |
Protein
Domains /
Families
for DDRGK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDRGK1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96HY6ProtoNet protein and cluster: Q96HY6 1 Blocks protein family: IPB000717 Domain in components of the proteasome
UniProtKB/Swiss-Prot: DDRGK_HUMAN, Q96HY6Similarity: Belongs to the DDRGK1 familySimilarity: Contains 1 PCI domain |
Function
for DDRGK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDRGK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDRGK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DDRGK1 (NM_023935) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDRGK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDRGK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDRGK1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
DDRGK1 for ontologies About GeneDecksing
|
Pathways & Interactions
for DDRGK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDRGK1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for DDRGK1 (Q96HY61, 3 ENSP000003464834) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for DDRGK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DDRGK1 for compounds About GeneDecksing
 Browse Tocris compounds for DDRGK1
1 PharmGKB related drug/compound annotation for DDRGK1 geneAbout this table
Search CenterWatch for drugs/clinical trials and news about DDRGK1 / DDRGK
|
Transcripts
for DDRGK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DDRGK1 gene: NM_023935.1 Unigene Cluster for DDRGK1: DDRGK domain containing 1 Hs.471975 [show with all ESTs]Unigene Representative Sequence: AK3108094 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000354488(uc002wic.3) ENST00000496781 ENST00000470203 ENST00000380201(uc010gax.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDRGK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDRGK1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DDRGK1 (NM_023935) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDRGK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDRGK1 |
Additional cDNA sequence: AF086090.1 AK310809.1 BC000643.1 BC007957.1 BC011851.1 10 DOTS entries: DT.100816724 DT.116418 DT.40305266 DT.120819851 DT.100816718 DT.100816722 DT.91812988 DT.120819836 DT.91746425 DT.95099689 24/233 AceView cDNA sequences (see all 233): AW328644 CR625227 BM763524 BU683068 CF127486 BM703050 CF127530 BM799784 CA412597 BM782105 CA423158 BQ574491 CA307728 AA532363 BM545118 AA484806 CA488019 BM765927 AA075563 BU846419 BM564917 BF725333 BF528118 BP431648
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DDRGK1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
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| SP1: | | | | | - | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DDRGK1
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Expression
for DDRGK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDRGK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGAGGAAC
About this image
See DDRGK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDRGK1
SOURCE GeneReport for Unigene cluster: Hs.471975
UniProtKB/Swiss-Prot: DDRGK_HUMAN, Q96HY6Tissue specificity: Ubiquitously expressed (at protein level)
SABiosciences Custom PCR Arrays for DDRGK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDRGK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDRGK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDRGK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDRGK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDRGK1 |
Orthologs
for DDRGK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DDRGK1 gene from 9/24 species (see all 24) About this table
ENSEMBL Gene Tree for DDRGK1 (if available)
TreeFam Gene Tree for DDRGK1 (if available) |
Paralogs
for DDRGK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DDRGK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DDRGK1 (3170996 - 3185331 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DDRGK1
1 CNV: 5121
Human Gene Mutation Database (HGMD): DDRGK1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDRGK1 |
|
Disorders
/ Diseases
for DDRGK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DDRGK1 for disorders About GeneDecksing
5  diseases for DDRGK1: About MalaCardshepatitis c thrombocytopenia anemia hepatitis
pancreatitis
Export disorders for DDRGK1 gene to outside databases
|
Publications
for DDRGK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DDRGK1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with DDRGK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. (PubMed id 21494687)1, 3 Lemaire K....Schuit F. (2011)
- Cloning and molecular characterization of Dashurin en coded by C20orf116, a PCI-domain containing protein. (PubMed id 20036718)1, 3 Neziri D....Wagner L. (2010)
- A novel type of E3 ligase for the Ufm1 conjugation system. (PubMed id 20018847)1, 2 Tatsumi K.... Komatsu M. (2010)
- A novel C53/LZAP-interacting protein regulates stabil ity of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF -kappaB signaling. (PubMed id 20228063)1, 3 Wu J....Li H. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for DDRGK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DDRGK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDRGK1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDRGK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DDRGK1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DDRGK1 gene:
Search GeneIP for patents involving DDRGK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDRGK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DDRGK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDRGK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDRGK1 | | | OriGene Protein Over-expression Lysate for DDRGK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DDRGK1 | | OriGene 3'-UTR Clone for DDRGK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDRGK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDRGK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DDRGK1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DDRGK1 | | OriGene Custom Protein Services for DDRGK1 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDRGK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDRGK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDRGK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDRGK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDRGK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDRGK1 |
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| | | | Search Tocris compounds for DDRGK1 |
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 | | | DDRGK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDRGK1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DDRGK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDRGK1 |
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