Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DDR2 Gene

protein-coding   GIFtS: 72
GCID: GC01P162601

Discoidin Domain Receptor Tyrosine Kinase 2

(Previous names: discoidin domain receptor family, member 2)
(Previous symbols: TYRO10, NTRKR3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Discoidin Domain Receptor Tyrosine Kinase 21 2     EC 2.7.10.13 8
NTRKR31 2 3 5     MIG20a2
TYRO101 2 3     Cell Migration-Inducing Protein 202
TKT2 3 5     Discoidin Domain-Containing Receptor 22
Discoidin Domain Receptor Family, Member 21 2     Hydroxyaryl-Protein Kinase2
Discoidin Domain Receptor 22 3     Migration-Inducing Gene 16 Protein2
Discoidin Domain-Containing Receptor Tyrosine Kinase 22 3     Neurotrophic Tyrosine Kinase Receptor Related 32
Neurotrophic Tyrosine Kinase, Receptor-Related 32 3     Tyrosylprotein Kinase2
Receptor Protein-Tyrosine Kinase TKT2 3     CD167b Antigen3
Tyrosine-Protein Kinase TYRO102 3     EC 2.7.108
CD167 Antigen-Like Family Member B2 3     

External Ids:    HGNC: 27311   Entrez Gene: 49212   Ensembl: ENSG000001627337   OMIM: 1913115   UniProtKB: Q168323   

Export aliases for DDR2 gene to outside databases

Previous GC identifers: GC01P160237 GC01P158253 GC01P159297 GC01P159789 GC01P159333 GC01P160868 GC01P133847


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DDR2 Gene:
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These
molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the
biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced
receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to
phosphorylation of cytosolic targets as well as association with other molecules, which are involved in
pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane,
and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct
extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in
multiple transcript variants encoding the same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDR2 Gene:
DDR2 (discoidin domain receptor tyrosine kinase 2) is a protein-coding gene. Diseases associated with DDR2 include spondylometaepiphyseal dysplasia short limb-hand type, and spondyloepiphyseal dysplasia congenita. GO annotations related to this gene include collagen binding and protein tyrosine kinase collagen receptor activity. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832
Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell
differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for
normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway
that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of
the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell
migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to
cutaneous wound healing

Gene Wiki entry for DDR2 (Discoidin domain-containing receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDR2 gene promoter:
         p53   SREBP-1c   Nkx2-5   HNF-3beta   SREBP-1b   Evi-1   MEF-2A   SREBP-1a   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDR2 promoter sequence
   Search Chromatin IP Primers for DDR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3   Ensembl cytogenetic band:  1q23.3   HGNC cytogenetic band: 1q12-q23

DDR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDR2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P162601:  view genomic region     (about GC identifiers)

Start:
162,601,163 bp from pter      End:
162,757,190 bp from pter
Size:
156,028 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832 (See protein sequence)
Recommended Name: Discoidin domain-containing receptor 2 precursor  
Size: 855 amino acids; 96736 Da
Subunit: Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO
motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1
2 PDB 3D structures from and Proteopedia for DDR2:
2WUH (3D)        2Z4F (3D)    
Secondary accessions: Q7Z730

Explore the universe of human proteins at neXtProt for DDR2: NX_Q16832

Explore proteomics data for DDR2 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation
    and subsequent autophosphorylation on additional tyrosine residues1
  • Glycosylation2 at Asn121, Asn213, Asn261, Asn280, Asn372
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDR2 (Q16832) (see all 15)
     YSGDYYR  FVHRDLA  GDGAWCP  DPLCMIT 


    See DDR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001014796.1  NP_006173.2  

    ENSEMBL proteins: 
     ENSP00000400309   ENSP00000391310   ENSP00000356899   ENSP00000356898   ENSP00000417030  
     ENSP00000396864  
    Reactome Protein details: Q16832

    DDR2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant DDR2 Protein
    R&D Systems Recombinant & Natural Proteins for DDR2
    Enzo Life Sciences proteins for DDR2
    OriGene Purified Proteins for DDR2
    OriGene Protein Over-expression Lysate for DDR2
    OriGene MassSpec for DDR2
    OriGene Custom Protein Services for DDR2
    GenScript Custom Purified and Recombinant Proteins Services for DDR2
    Novus Biologicals DDR2 Proteins
    Novus Biologicals DDR2 Lysates
    Sino Biological Recombinant Protein for DDR2
    Sino Biological Cell Lysate for DDR2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDR2

    DDR2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DDR2
    Cell Signaling Technology (CST) Antibodies for DDR2 
    OriGene Antibodies for DDR2
    OriGene Custom Antibody Services for DDR2
    Novus Biologicals DDR2 Antibodies
    Abcam antibodies for DDR2
    Cloud-Clone Corp. Antibodies for DDR2
    ThermoFisher Antibody for DDR2
    LSBio Antibodies in human, mouse, rat for DDR2

    DDR2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDR2
    R&D Systems ELISAs for DDR2         (see all)
    GenScript Custom Assay Services for DDR2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDR2
    Cloud-Clone Corp. CLIAs for DDR2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: discoidin domain receptor tyrosine kinase 2
    DDR (collagen receptor) family
    DDR (collagen receptor) family

    Selected InterPro protein domains (see all 8):
     IPR011009 Kinase-like_dom
     IPR002011 Tyr_kinase_rcpt_2_CS
     IPR000719 Prot_kinase_dom
     IPR008979 Galactose-bd-like
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q16832

    ProtoNet protein and cluster: Q16832

    3 Blocks protein domains:
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB002011 Receptor tyrosine kinase
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 1 F5/8 type C domain
    Similarity: Contains 1 protein kinase domain


    DDR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDR2_HUMAN, Q16832
    Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell
    differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for
    normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway
    that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of
    the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell
    migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to
    cutaneous wound healing
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Present in an inactive state in the absence of collagen binding and phosphorylation by SRC.
    Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity
    Induction: Up-regulated during osteoblast differentiation (in vitro). Up-regulated in cartilage from
    osteoarthritis patients

         Genatlas biochemistry entry for DDR2:
    discoidin domain recptor family,member 2,expressed in heart and lung

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA--
    GO:0005515protein binding IPI17703188
    GO:0005518collagen binding IDA--
         
    DDR2 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ddr2):
     adipose tissue  cellular  craniofacial  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  mortality/aging  nervous system  reproductive system  skeleton 
     vision/eye 

    DDR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ddr2tm1Kln for DDR2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDR2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDR2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDR2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDR2:
    hsa-mir-21-5p (MIRT030671)

    Block miRNA regulation of human, mouse, rat DDR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DDR2
    SwitchGear 3'UTR luciferase reporter plasmidDDR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDR2
    Predesigned siRNA for gene silencing in human, mouse, rat DDR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDR2

    Clone
    Products:
         
    OriGene clones in human, mouse for DDR2 (see all 13)
    OriGene ORF clones in mouse, rat for DDR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DDR2 (NM_006182)
    Sino Biological Human cDNA Clone for DDR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDR2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for DDR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DDR2_HUMAN, Q16832: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9659899
    GO:0016324apical plasma membrane IEA--

    DDR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DDR2 About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    CDC42 Pathway0.41
    Actin Nucleation by ARP-WASP Complex0.66
    5Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DDR2
        Articular Cartilage Extracellular Matrix

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DDR2 (see all 29)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    2 Cell Signaling Technology (CST) Pathways for DDR2
        Tyrosine Kinases / Adaptors
    Adhesion

    1 BioSystems Pathway for DDR2
        Endochondral Ossification


    1 Reactome Pathway for DDR2
        Non-integrin membrane-ECM interactions



    DDR2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDR2
    Interactions:

        GeneGlobe Interaction Network for DDR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for DDR2 (Q168321, 2, 3 ENSP000003568984) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COL11A2P139421, 2, 3EBI-1381484,EBI-2515504 MINT-5222456 MINT-6167968 I2D: score=1 
    ENSG00000206290P139421, 2, 3EBI-1381484,EBI-2515504 MINT-5222456 MINT-6167968 I2D: score=1 
    ENSG00000227801P139421, 2, 3EBI-1381484,EBI-2515504 MINT-5222456 MINT-6167968 I2D: score=1 
    ENSG00000230930P139421, 2, 3EBI-1381484,EBI-2515504 MINT-5222456 MINT-6167968 I2D: score=1 
    ENSG00000235708P139421, 2, 3EBI-1381484,EBI-2515504 MINT-5222456 MINT-6167968 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0003416endochondral bone growth ISS--
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS9659899

    DDR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for DDR2
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDR2

    2 HMDB Compounds for DDR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 Novoseek inferred chemical compound relationship for DDR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 66.1 46 16186108 (3), 18938156 (2), 17712722 (2), 11884411 (2) (see all 26)



    DDR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DDR2 gene (2 alternative transcripts): 
    NM_001014796.1  NM_006182.2  

    Unigene Clusters for DDR2:

    Discoidin domain receptor tyrosine kinase 2
    Hs.275757  [show with all ESTs], Hs.593833  [show with all ESTs]
    Unigene Representative Sequences: BX537651, BC052998
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000446985 ENST00000415555 ENST00000367922(uc001gcf.3 uc001gcg.3)
    ENST00000367921 ENST00000458105 ENST00000433757
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDR2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DDR2
    SwitchGear 3'UTR luciferase reporter plasmidDDR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDR2
    Predesigned siRNA for gene silencing in human, mouse, rat DDR2
    Clone
    Products:
         
    OriGene clones in human, mouse for DDR2 (see all 13)
    OriGene ORF clones in mouse, rat for DDR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DDR2 (NM_006182)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDR2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDR2
    OriGene qSTAR qPCR primer pairs in human, mouse for DDR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDR2
      QuantiTect SYBR Green Assays in human, mouse, rat DDR2
      QuantiFast Probe-based Assays in human, mouse, rat DDR2

    Additional mRNA sequence: 

    AK095975.1 AK225063.1 AK225196.1 AK314388.1 BC052998.2 BX640899.1 X74764.1 

    9 DOTS entries:

    DT.314246  DT.40232391  DT.121365239  DT.99974734  DT.121365274  DT.97766383  DT.98082904  DT.100786284 
    DT.40115230 

    Selected AceView cDNA sequences (see all 359):

    W58588 AA029184 CA416400 AI610743 BQ682363 AA625532 BF433752 BE645834 
    NM_006182 BQ182509 AK093908 W61267 BU168475 AA155952 AI686162 AA910805 
    BU623939 BQ005646 CB143655 AA902526 BU625513 X74764 AA155907 BQ717033 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DDR2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19
    SP1:                                      -                                                                       -                                 
    SP2:                    -                 -                                                                       -                                 
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for DDR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DDR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTACTGAAAA
    DDR2 Expression
    About this image


    DDR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Intermediate Mesoderm (Gastrulation Derivatives)
             Mesonephros
    DDR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDR2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.275757 Hs.593833

    UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832
    Tissue specificity: Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and
    cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta,
    liver, skeletal muscle, pancreas, and kidney

        Custom PCR Arrays for DDR2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDR2
    OriGene qSTAR qPCR primer pairs in human, mouse for DDR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDR2
    QuantiTect SYBR Green Assays in human, mouse, rat DDR2
    QuantiFast Probe-based Assays in human, mouse, rat DDR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DDR2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddr21 , 5 discoidin domain receptor family, member 21, 5 90.24(n)1
    96.02(a)1
      1 (76.84 cM)5
    182141  NM_022563.21  NP_072075.21 
     1699723075 
    chicken
    (Gallus gallus)
    Aves DDR21 discoidin domain receptor tyrosine kinase 2 76.75(n)
    85.77(a)
      396404  XM_004943146.1  XP_004943203.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDR26
    discoidin domain receptor tyrosine kinase 2
    86(a)
    1 ↔ 1
    GL343300.1(1081483-1135581)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004978891 discoidin domain-containing receptor 2-like 75.13(n)
    83.56(a)
      100497889  XM_002933778.2  XP_002933824.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ddr2a1 discoidin domain receptor tyrosine kinase 2a 72.78(n)
    79.25(a)
      556380  XM_005166263.1  XP_005166320.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ddr1 Discoidin domain receptor 49.78(n)
    42.03(a)
      3346209  NM_001014474.3  NP_001014474.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F11D5.3a3
    ddr-21
    tyrosine kinase3
    ddr-21
    32(a)
    (best of 3)3
    47.54(n)1
    36.81(a)1
      X(3350646-3359262)3
    1806221  NM_076171.41  NP_508572.11 


    ENSEMBL Gene Tree for DDR2 (if available)
    TreeFam Gene Tree for DDR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DDR2 gene
    ROR12  INSR2  ROS12  NTRK22  LTK2  IGF1R2  DDR12  NTRK32  
    INSRR2  ROR22  MUSK2  ALK2  NTRK12  
    5 SIMAP similar genes for DDR2 using alignment to 5 protein entries:     DDR2_HUMAN (see all proteins):
    DKFZp686D1354    DDR1    NRP2    NRP1    MFGE8

    DDR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DDR2 (see all 3118)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0630514
    Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL)4--see VAR_0630512 I R mis40--------
    VAR_0630504
    Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL)4--see VAR_0630502 T I mis40--------
    VAR_0414984
    A lung large cell carcinoma sample4--see VAR_0414982 R S mis40--------
    VAR_0630524
    Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL)4--see VAR_0630522 R C mis40--------
    VAR_0657194
    Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL)4--see VAR_0657192 E K mis40--------
    rs2010297491,2
    --133904720(+) TCTAC-/TTAAAA 2 -- int10--------
    rs748365951,2
    C--133913949(+) GTTGT-/TA    
       AATAG
    CTGCA
    2 -- int10--------
    rs799505741,2
    C--133957768(-) TCTTCC/GTCATT 2 -- int11Minor allele frequency- G:0.00NA 2
    rs759174591,2
    C--133992378(+) GTACA-/CACGTTT 2 -- int10--------
    rs3718509371,2
    C--133992680(+) TGAGG-/CT/TC 
            
    GGAGG
    2 -- int10--------

    HapMap Linkage Disequilibrium report for DDR2 (162601163 - 162757190 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DDR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3299CNV Insertion18451855
    esv268951CNV Insertion20981092
    nsv516482CNV Gain+Loss19592680

    Human Gene Mutation Database (HGMD): DDR2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDR2
    DNA2.0 Custom Variant and Variant Library Synthesis for DDR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 191311   
    OMIM disorders: 271665  
    UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832
  • Spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL) [MIM:271665]: A bone disease
    characterized by short-limbed dwarfism, a narrow chest with pectus excavatum, brachydactyly in the hands and
    feet, a characteristic craniofacial appearance and premature calcifications. The radiological findings are
    distinctive and comprise short long bones throughout the skeleton with striking epiphyses that are stippled,
    flattened and fragmented and flared, irregular metaphyses. Platyspondyly in the spine with wide intervertebral
    spaces is observed and some vertebral bodies are pear-shaped with central humps, anterior protrusions and
    posterior scalloping. Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for DDR2 (see all 28):    
    About MalaCards
    spondylometaepiphyseal dysplasia short limb-hand type    spondyloepiphyseal dysplasia congenita    retinoschisis    lymphangioleiomyomatosis
    brachydactyly    dwarfism    osteoarthritis    fibrosarcoma
    primary biliary cirrhosis    papillary thyroid carcinoma    scleroderma    essential hypertension
    atherosclerosis    hypertension    hodgkin's lymphoma    thyroiditis
    rheumatoid arthritis    arthritis    hypoxia    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for DDR2:
    Osteoarthritis

    DDR2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for DDR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoarthritis 44.4 10 17968949 (2), 17665456 (1), 12419287 (1), 19267386 (1) (see all 5)
    liver fibrosis 42.9 5 12220173 (1), 15591520 (1), 17024850 (1)
    fibrosarcoma 26.4 1 12935821 (1)
    atherosclerosis 0 1 15111304 (1)
    tumors 0 7 17427955 (1), 16186104 (1), 9075249 (1)

    Genetic Association Database (GAD): DDR2
    Human Genome Epidemiology (HuGE) Navigator: DDR2 (3 documents)

    Export disorders for DDR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DDR2 gene, integrated from 10 sources (see all 100):
    (articles sorted by number of sources associating them with DDR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The discoidin domain receptor tyrosine kinases are activated by collagen. (PubMed id 9659899)1, 2, 3 Vogel W.... Pawson T. (Mol. Cell 1997)
    2. Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. (PubMed id 16186108)1, 2, 9 Yang K.... Yang B.S. (J. Biol. Chem. 2005)
    3. Trafficking defects and loss of ligand binding are the underlying causes of all reported DDR2 missense mutations found in SMED-SL patients. (PubMed id 20223752)1, 2, 9 Ali B.R.... Leitinger B. (Hum. Mol. Genet. 2010)
    4. Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen. (PubMed id 18201965)1, 2, 9 Konitsiotis A.D....Leitinger B. (J. Biol. Chem. 2008)
    5. Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications. (PubMed id 19110212)1, 2, 9 Bargal R....Raas-Rothschild A. (Am. J. Hum. Genet. 2009)
    6. Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII- like domain. (PubMed id 8247548)1, 2, 9 Karn T.... Strebhardt K. (Oncogene 1993)
    7. Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. (PubMed id 16186104)1, 2, 9 Wall S.J.... DeClerck Y.A. (J. Biol. Chem. 2005)
    8. Structural basis of the collagen-binding mode of discoidin domain receptor 2. (PubMed id 17703188)1, 2, 9 Ichikawa O.... Shimada I. (EMBO J. 2007)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4921 HGNC: 2731 AceView: DDR2 Ensembl:ENSG00000162733 euGenes: HUgn4921
    ECgene: DDR2 H-InvDB: DDR2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DDR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDR2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DDR2 gene:
    Search GeneIP for patents involving DDR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant DDR2 Protein
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for DDR2 (DDR2)   Browse Cell Culture Products  
     ELISAs for DDR2 (DDR2)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for DDR2 (DDR2)   Browse Stem Cell Products  
     Browse cDNA Clones   Proteome Profiler Antibody Arrays for DDR2 (DDR2)  
     OriGene Antibodies for DDR2   OriGene RNAi products in human, mouse, rat for DDR2  
     OriGene qPCR primer pairs and template standards for DDR2   OriGene Protein Over-expression Lysate for DDR2  
     OriGene MassSpec something-or-other for DDR2   OriGene clones in human, mouse for DDR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for DDR2   OriGene Purified Protein for DDR2  
     OriGene ORF clones in mouse, rat for DDR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDR2   OriGene Custom Protein Services for DDR2  

     
     
     Block miRNA regulation of human, mouse, rat DDR2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DDR2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDR2 Predesigned siRNA for gene silencing in human, mouse, rat DDR2
     QuantiFast Probe-based Assays in human, mouse, rat DDR2 QuantiTect SYBR Green Assays in human, mouse, rat DDR2
     Custom PCR Arrays for DDR2 Search Chromatin IP Primers for DDR2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDR2  GeneGlobe Interaction Network for DDR2
     Regulatory tfbs in DDR2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DDR2 GenScript cDNA clones with any tag delivered in your preferred vector for DDR2
     GenScript Custom Assay Services for DDR2 GenScript Custom overexpressing Cell Line Services for DDR2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for DDR2 

     Search Tocris compounds for DDR2
     Proteins for DDR2
     Cell Lysates for DDR2
     cDNA Clones for DDR2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs/Proteins for DDR2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DDR2 antibodies
     DDR2 proteins
     DDR2 lysates
     Antibodies for DDR2
     See all of Abcam's Antibodies, Kits and Proteins for DDR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DDR2
     Antibodies for DDR2
     ELISAs for DDR2
     CLIAs for DDR2



     Browse ESI BIO Cell Lines and PureStem Progenitors for DDR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR2
     SwitchGear 3'UTR luciferase reporter plasmids for DDR2
     SwitchGear Promoter luciferase reporter plasmids for DDR2
     ThermoFisher Antibody for DDR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDR2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDR2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDR2
     LSBio Antibodies in human, mouse, rat for DDR2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DDR2 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4