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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DDR2 Gene

protein-coding GIFtS: 68
GCID: GC01P162601

discoidin domain receptor tyrosine kinase 2

(Previous names: discoidin domain receptor family, member 2 )
(Previous symbols: TYRO10, NTRKR3)

Explore 32 diseases affiliated with
DDR2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Discoidin Domain Receptor Tyrosine Kinase 2¹ ²		EC 2.7.10.1³ ⁸
NTRKR3¹ ² ³ ⁵		MIG20a²
TKT¹ ² ³ ⁵		Cell Migration-Inducing Protein 20²
TYRO10¹ ² ³		Discoidin Domain-Containing Receptor 2²
Discoidin Domain Receptor Family, Member 2¹ ²		Hydroxyaryl-Protein Kinase²
Discoidin Domain Receptor 2² ³		Migration-Inducing Gene 16 Protein²
Discoidin Domain-Containing Receptor Tyrosine Kinase 2² ³		Neurotrophic Tyrosine Kinase Receptor Related 3²
Neurotrophic Tyrosine Kinase, Receptor-Related 3² ³		Tyrosylprotein Kinase²
Receptor Protein-Tyrosine Kinase TKT² ³		CD167b Antigen³
Tyrosine-Protein Kinase TYRO10² ³		EC 2.7.10⁸
CD167 Antigen-Like Family Member B² ³

External Ids:	HGNC: 2731¹	Entrez Gene: 4921²	Ensembl: ENSG00000162733⁷	OMIM: 191311⁵	UniProtKB: Q16832³

Export aliases for DDR2 gene to outside databases

Previous GC identifers: GC01P160237 GC01P158253 GC01P159297 GC01P159789 GC01P159333 GC01P160868 GC01P133847

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDR2:

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These

molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the

biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor

oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of

cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal

transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene

encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor

VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same

protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832

Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell

differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal

bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that

involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the

extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration

and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound

healing

Gene Wiki entry for DDR2 (Discoidin domain-containing receptor 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DDR2 gene promoter:
p53 SREBP-1c Nkx2-5 HNF-3beta SREBP-1b Evi-1 MEF-2A SREBP-1a aMEF-2 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDR2 promoter sequence

Search SABiosciences Chromatin IP Primers for DDR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.3 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q12-q23

DDR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDR2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P162601: view genomic region (about GC identifiers)

Start:	162,601,163 bp from pter	End:	162,750,255 bp from pter
Size:	149,093 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832 (See protein sequence)

Recommended Name: Discoidin domain-containing receptor 2 precursor

Size: 855 amino acids; 96736 Da

Subunit: Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif,

where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1

Subcellular location: Cell membrane; Single-pass type I membrane protein

2 PDB 3D structures from and Proteopedia for DDR2:

2WUH (3D)

2Z4F (3D)

Secondary accessions: Q7Z730

Explore the universe of human proteins at neXtProt for DDR2: NX_Q16832

Post-translational modifications:

N-glycosylated¹

Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and

subsequent autophosphorylation on additional tyrosine residues¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16832

4/15 DME Specific Peptides for DDR2 (Q16832) (see all 15)

YSGDYYR

FVHRDLA

GDGAWCP

DPLCMIT

DDR2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001014796.1 NP_006173.2

ENSEMBL proteins:

ENSP00000400309 ENSP00000391310 ENSP00000356899 ENSP00000356898 ENSP00000417030

ENSP00000396864

Human Recombinant Protein Products for DDR2:

	EMD Millipore Purified and/or Recombinant DDR2 Protein
	R&D Systems Recombinant & Natural Proteins for DDR2
	Enzo Life Sciences proteins for DDR2
	OriGene Purified Proteins (see all 2): DDR2 OriGene Protein Over-expression Lysate (see all 3): DDR2 OriGene Custom Protein Services for DDR2
	GenScript Custom Purified and Recombinant Proteins Services for DDR2
	Novus Biologicals DDR2 Proteins Novus Biologicals DDR2 Lysates
	Sino Biological Recombinant Protein for DDR2
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DDR2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005887	integral to plasma membrane	TAS	9659899

DDR2 for ontologies About GeneDecksing

DDR2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for DDR2
	Cell Signaling Technology (CST) Antibodies for DDR2
	OriGene Antibodies: DDR2 OriGene Custom Antibody Services for DDR2
	GenScript Custom Superior Antibodies Services for DDR2
	Novus Biologicals DDR2 Antibodies
	Abcam antibodies for DDR2
	Uscn Antibodies for DDR2
	ThermoFisher Antibody for DDR2

Assay Products for DDR2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for DDR2 (see all)
	GenScript Custom Assay Services for DDR2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DDR2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DDR2 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR011009 Kinase-like_dom

IPR002011 Tyr_kinase_rcpt_2_CS

IPR000719 Prot_kinase_cat_dom

IPR008979 Galactose-bd-like

IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q16832

ProtoNet protein and cluster: Q16832

3 Blocks protein families:

IPB000421 Coagulation factor 5/8 type C domain (FA58C)

IPB002011 Receptor tyrosine kinase

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily

Similarity: Contains 1 F5/8 type C domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DDR2_HUMAN, Q16832

Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell

differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal

bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that

involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the

extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration

and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound

healing

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme regulation: Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine

phosphorylation enhances the affinity for ATP and the catalytic activity

Induction: Up-regulated during osteoblast differentiation (in vitro). Up-regulated in cartilage from osteoarthritis

patients

Genatlas biochemistry entry for DDR2:

discoidin domain recptor family,member 2,expressed in heart and lung

Enzyme Numbers (IUBMB): EC 2.7.10.1¹ ² EC 2.7.10²

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IDA	--
GO:0004872	receptor activity	--	--
GO:0005515	protein binding	IPI	--
GO:0005518	collagen binding	IDA	--
GO:0005524	ATP binding	IEA	--

DDR2 for ontologies About GeneDecksing

Phenotypes:
11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ddr2):

adipose tissue	cellular	craniofacial	endocrine/exocrine gland	growth/size
homeostasis/metabolism	mortality/aging	nervous system	reproductive system	skeleton
vision/eye

DDR2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ddr2^tm1Kln for DDR2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DDR2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): DDR2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDR2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DDR2
		SwitchGear 3'UTR luciferase reporter plasmid: DDR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDR2 (see all 7) OriGene shRNA RFP: DDR2 OriGene siRNA: DDR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDR2
		Sirion Biotech Custom design and validation of potent shRNA sequences against DDR2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for DDR2
			Sirion Biotech Customized adenovirus for overexpression of DDR2 Sirion Biotech Customized adenovirus for potent knockdown of DDR2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDR2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDR2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DDR2 (NM_006182)
		Sino Biological Human cDNA Clone for DDR2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDR2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DDR2
		Search LifeMap BioReagents cell lines for DDR2
		Sirion Biotech Customized stable knockdown cell line services for DDR2 Sirion Biotech Customized inducible knockdown cell line services for DDR2 Sirion Biotech Customized stable overexpressing cell line services for DDR2 Sirion Biotech Customized inducible overexpressing cell line services for DDR2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation by ARP-WASP Complex	1.00			CDC42 Pathway	0.34
	Actin Nucleation and Branching	0.66

Akt Signaling

Akt Signaling

1.00

p38 Signaling

0.60

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for DDR2

Articular Cartilage Extracellular Matrix

5/29 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DDR2 (see all 29)

	MAPK Signaling
	Paxillin Interactions
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling

2 Cell Signaling Technology (CST) Pathways for DDR2

	Tyrosine Kinases / Adaptors
	Adhesion

1 BioSystems Pathway for DDR2

Endochondral Ossification

DDR2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DDR2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/8 Interacting proteins for DDR2 (Q16832^{1, 2, 3} ENSP00000356898⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SHC1	P29353²^,³, ENSP00000401303⁴	MINT-13958 MINT-13959 I2D: score=3 STRING: ENSP00000401303
COL11A2	P13942²^,³	MINT-5222456 MINT-6167968 I2D: score=1
SRC	P12931²^,³, ENSP00000350941⁴	MINT-14765 I2D: score=3 STRING: ENSP00000350941
COL1A1	P02452³, ENSP00000225964⁴	I2D: score=1 STRING: ENSP00000225964
COL3A1	P02461³, ENSP00000304408⁴	I2D: score=1 STRING: ENSP00000304408

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0003416	endochondral bone growth	ISS	--
GO:0007155	cell adhesion	IEA	--
GO:0007165	signal transduction	TAS	9659899
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	--	--

DDR2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DDR2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Enzo Life Sciences drugs & compounds for DDR2

Browse Tocris compounds for DDR2

2 HMDB Compounds for DDR2 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

1 Novoseek chemical compound relationship for DDR2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	66.1	46	16186108 (3), 18938156 (2), 17712722 (2), 11884411 (2) (see all 26)

Search CenterWatch for drugs/clinical trials and news about DDR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DDR2 gene (2 alternative transcripts):

NM_001014796.1 NM_006182.2

Unigene Clusters for DDR2:

Discoidin domain receptor tyrosine kinase 2

Hs.275757 [show with all ESTs], Hs.593833 [show with all ESTs]

Unigene Representative Sequences: BX537651, BC052998

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000446985 ENST00000415555 ENST00000367922(uc001gcf.3 uc001gcg.3)

ENST00000367921 ENST00000458105 ENST00000433757

miRNA Products:		OriGene 3'-UTR Clone (see all 2): DDR2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDR2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DDR2
		SwitchGear 3'UTR luciferase reporter plasmid: DDR2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDR2 (see all 7) OriGene shRNA RFP: DDR2 OriGene siRNA: DDR2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDR2
		Sirion Biotech Custom design and validation of potent shRNA sequences against DDR2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDR2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDR2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DDR2 (NM_006182)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDR2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDR2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DDR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDR2

Additional cDNA sequence:

AK095975.1 AK225063.1 AK225196.1 AK314388.1 BC052998.2 BX640899.1 X74764.1

9 DOTS entries:

DT.314246 DT.40232391 DT.121365239 DT.99974734 DT.121365274 DT.97766383 DT.98082904 DT.100786284

DT.40115230

24/359 AceView cDNA sequences (see all 359):

BQ678490 BQ019968 BQ695041 AW298079 AA032248 AA155907 BQ717033 BQ017707

X74764 AA621907 AA736386 AI193399 AL598098 BX503825 AI754442 CD558167

BF197697 N70026 BE550765 AA621726 BM694230 BE328844 AA029183 AA034139

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DDR2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b	^	15	^	16	^	17	^	18	^	19
SP1:													-																								-
SP2:							-						-																								-
SP3:
SP4:

ECgene alternative splicing isoforms for DDR2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DDR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTACTGAAAA

About this image

DDR2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Myocardium

Cardiac Fibroblasts

Selective marker (cell-identifying gene)

Epicardium

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

See DDR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDR2

SOURCE GeneReport for Unigene clusters: Hs.275757 Hs.593833

UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832

Tissue specificity: Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and

cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver,

skeletal muscle, pancreas, and kidney

SABiosciences Custom PCR Arrays for DDR2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDR2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DDR2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDR2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDR2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DDR2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DDR2¹	discoidin domain receptor tyrosine kinase 2	78.75(n) 88.65(a)		396404 XM_422211.3 XP_422211.3
lizard (Anolis carolinensis)	Reptilia	DDR2⁶	--	86(a)	1 ↔ 1	GL343300.1(1083068-1124723)
zebrafish (Danio rerio)	Actinopterygii	ddr2a¹	discoidin domain receptor tyrosine kinase 2a	73.55(n) 79.98(a)		556380 XM_679169.4 XP_684261.4
fruit fly (Drosophila melanogaster)	Insecta	Ddr¹	Discoidin domain receptor	48.86(n) 40.96(a)		3346209 NM_001014474.3 NP_001014474.2
worm (Caenorhabditis elegans)	Secernentea	F11D5.3a³	tyrosine kinase	32(a) (best of 3)		X(3350646-3359262) --

ENSEMBL Gene Tree for DDR2 (if available)
TreeFam Gene Tree for DDR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DDR2 gene

INSR² ROR1² ROS1² NTRK2² LTK² IGF1R² DDR1² NTRK3²

ROR2² INSRR² MUSK² ALK² NTRK1²

5 SIMAP similar genes for DDR2 using alignment to 5 protein entries: DDR2_HUMAN (see all proteins):

DKFZp686D1354 DDR1 NRP2 NRP1 MFGE8

DDR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75551760^1,2	C,F	--	133846987(+)	`GGCGGG/AGGGGT`	2	--	us2k¹		1		NA	120
rs2292335^1,2	C,H	--	133847465(-)	`TTGGAA/GAGAAG`	2	--	ut5¹ trp³		5		NS EA NA	420
rs11803810^1,2	H	--	133849074(+)	`TGATTA/TCTGGG`	2	--	int¹		0	--	--	--	--
rs72707617^1,2	C	--	133849544(+)	`TTAAAC/TTCTCC`	2	--	int¹		0	--	--	--	--
rs73016517^1,2	C,F	--	133849779(+)	`CTTTCC/TCTGGC`	2	--	int¹		4		WA CSA	124
rs6658082^1,2	C,F,H	--	133850423(+)	`ACTGGA/GCTCTT`	2	--	int¹		5		NS EA WA	534
rs61810405^1,2	C,F	--	133850872(+)	`TTGGAA/GCATCA`	2	--	int¹		6		NA CSA WA EA	364
rs78980207^1,2	F	--	133850981(+)	`ATGTAC/TGATTT`	2	--	int¹		1		WA	118
rs113275618^1,2	C	--	133851427(+)	`CTTCAG/CATGCG`	2	--	int¹		1		NA	2
rs61810406^1,2	C,F	--	133851984(+)	`TCTCTG/CCTGGA`	2	--	int¹		4		NA CSA	126

HapMap Linkage Disequilibrium report for DDR2 (162601163 - 162750255 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DDR2
1 CNV: 48150
Human Gene Mutation Database (HGMD): DDR2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDR2

DNA2.0 Custom Variant and Variant Library Synthesis for DDR2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DDR2 for disorders           About GeneDecksing

OMIM gene information: 191311
OMIM disorders: 271665
UniProtKB/Swiss-Prot: DDR2_HUMAN, Q16832

Defects in DDR2 are the cause of spondyloepimetaphyseal dysplasia short limb-hand type (SEMD-SL) [MIM:271665].

A bone disease characterized by short-limbed dwarfism, a narrow chest with pectus excavatum, brachydactyly in the

hands and feet, a characteristic craniofacial appearance and premature calcifications. The radiological findings are

distinctive and comprise short long bones throughout the skeleton with striking epiphyses that are stippled, flattened

and fragmented and flared, irregular metaphyses. Platyspondyly in the spine with wide intervertebral spaces is

observed and some vertebral bodies are pear-shaped with central humps, anterior protrusions and posterior scalloping

20/32 diseases for DDR2 (see all 32): About MalaCards

spondylometaepiphyseal dysplasia short limb-hand type spondyloepiphyseal dysplasia congenita non-small cell lung carcinoma spondyloepiphyseal dysplasia

primary biliary cirrhosis semd retinoschisis papillary thyroid carcinoma

essential hypertension lymphangioleiomyomatosis fibrosarcoma brachydactyly

dwarfism hodgkin's lymphoma thyroid carcinoma rheumatoid arthritis

osteoarthritis lung carcinoma atherosclerosis thyroiditis

1 disease from the University of Copenhagen DISEASES database for DDR2:

Osteoarthritis

5 Novoseek disease relationships for DDR2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
osteoarthritis	44.4	10	17968949 (2), 17665456 (1), 12419287 (1), 19267386 (1) (see all 5)
liver fibrosis	42.9	5	12220173 (1), 15591520 (1), 17024850 (1)
fibrosarcoma	26.4	1	12935821 (1)
atherosclerosis	0	1	15111304 (1)
tumors	0	7	17427955 (1), 16186104 (1), 9075249 (1)

Human Genome Epidemiology (HuGE) Navigator: DDR2 (3 documents)

Export disorders for DDR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DDR2 gene, integrated from 9 sources (see all 88):
(articles sorted by number of sources associating them with DDR2)

Utopia: connect your pdf to the dynamic
world of online information

The discoidin domain receptor tyrosine kinases are activated by collagen. (PubMed id 9659899)^{1, 2, 3} Vogel W....Pawson T. (1997)
Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Src stimulates intramolecular autophosphorylation and Shc signaling complex formation. (PubMed id 16186108)^{1, 2, 9} Yang K....Yang B.S. (2005)
Trafficking defects and loss of ligand binding are th e underlying causes of all reported DDR2 missense mutations found in SMED-SL pa tients. (PubMed id 20223752)^{1, 2, 9} Ali B.R....Leitinger B. (2010)
Characterization of high affinity binding motifs for the discoidin domain receptor DDR2 in collagen. (PubMed id 18201965)^{1, 2, 9} Konitsiotis A.D....Leitinger B. (2008)
Mutations in DDR2 gene cause SMED with short limbs and abnormal calcifications. (PubMed id 19110212)^{1, 2, 9} Bargal R....Raas-Rothschild A. (2009)
Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII- like domain. (PubMed id 8247548)^{1, 2, 9} Karn T.... Strebhardt K. (1993)
Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen. (PubMed id 16186104)^{1, 2, 9} Wall S.J....DeClerck Y.A. (2005)
Structural basis of the collagen-binding mode of discoidin domain receptor 2. (PubMed id 17703188)^{1, 2, 9} Ichikawa O.... Shimada I. (2007)
Transcriptional upregulation of DDR2 by ATF4 facilita tes osteoblastic differentiation through p38 MAPK-mediated Runx2 activation. (PubMed id 20564243)^{1, 2} Lin K.L....Wang F.F. (2010)
Sensing extracellular matrix: an update on discoidin domain receptor function. (PubMed id 16626936)^{1, 2} Vogel W.F....Ford C.E. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4921	HGNC: 2731	AceView: DDR2	Ensembl:ENSG00000162733	euGenes: HUgn4921
ECgene: DDR2	H-InvDB: DDR2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DDR2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DDR2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DDR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DDR2 gene:
Search GeneIP for patents involving DDR2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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DDR2 Gene

discoidin domain receptor tyrosine kinase 2

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DDR2 (Gene Symbol)
Discoidin Domain Receptor Tyrosine Kinase 2
NTRKR3
TKT
TYRO10
Discoidin Domain Receptor Family, Member 2
Discoidin Domain Receptor 2
Discoidin Domain-Containing Receptor Tyrosine Kinase 2
Neurotrophic Tyrosine Kinase, Receptor-Related 3
Receptor Protein-Tyrosine Kinase TKT
Tyrosine-Protein Kinase TYRO10
CD167 Antigen-Like Family Member B
EC 2.7.10.1
MIG20a
Cell Migration-Inducing Protein 20
Discoidin Domain-Containing Receptor 2
Hydroxyaryl-Protein Kinase
Migration-Inducing Gene 16 Protein
Neurotrophic Tyrosine Kinase Receptor Related 3
Tyrosylprotein Kinase
CD167b Antigen
EC 2.7.10

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DDR2 Gene

discoidin domain receptor tyrosine kinase 2

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