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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDR1 Gene

protein-coding   GIFtS: 66
GCID: GC06P030848

discoidin domain receptor tyrosine kinase 1

(Previous names: discoidin domain receptor family, member 1 )
(Previous symbols: NTRK4, PTK3A, NEP, CAK, EDDR1)
 Explore 53 diseases affiliated with
DDR1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DDR1    

Aliases
for DDR1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Discoidin Domain Receptor Tyrosine Kinase 11 2     Discoidin Domain Receptor Family, Member 11
NEP1 2 3 5     DDR2
CAK1 2 3     MCK102
EDDR11 2 3     PTK32
NTRK41 2 3     Epithelial Discoidin Domain-Containing Receptor 12
PTK3A1 2 3     Neuroepithelial Tyrosine Kinase2
RTK61 2 3     Neurotrophic Tyrosine Kinase, Receptor, Type 42
TRKE2 3 5     PTK3A Protein Tyrosine Kinase 3A2
CD1671 2     MCK-103
Cell Adhesion Kinase2 3     CD167a Antigen3
Mammary Carcinoma Kinase 102 3     Discoidin Receptor Tyrosine Kinase3
Protein-Tyrosine Kinase RTK-62 3     Epithelial Discoidin Domain Receptor 13
Tyrosine Kinase DDR2 3     Protein-Tyrosine Kinase 3A3
Tyrosine-Protein Kinase CAK2 3     TRK E3
HGK22 3     ENTRK45
CD167 Antigen-Like Family Member A2 3     EC 2.7.108
EC 2.7.10.13 8     

External Ids:    HGNC: 27301   Entrez Gene: 7802   Ensembl: ENSG000002045807   OMIM: 6004085   UniProtKB: Q083453   

Export aliases for DDR1 gene to outside databases

Previous GC identifers: GC06P030907 GC06P030619 GC06P030959 GC06P030960 GC06P030631 GC06P030653


Summaries
for DDR1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DDR1:
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are
involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to
a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their
extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to
epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown
to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding
different isoforms have been described for this gene. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment
to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and
cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP
kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7
and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during
pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and
normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound
healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11

Gene Wiki entry for DDR1


Genomic Views
for DDR1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDR1 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

DDR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDR1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030848:  view genomic region     (about GC identifiers)

Start:
 30,844,198 bp from pter      End:
 30,867,933 bp from pter
Size:
 23,736 bases      Orientation:
 plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_3 30,839,458-30,869,692      Chr6+,ALT_REF_LOCI_4 30,819,605-30,835,673      Chr6+,ALT_REF_LOCI_2 30,838,646-30,897,017     
Chr6+,ALT_REF_LOCI_5 30,845,241-30,866,077      Chr6+,ALT_REF_LOCI_1 30,861,248-30,873,781      Chr6+,ALT_REF_LOCI_6 30,838,342-30,893,106     

Proteins
for DDR1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 (See protein sequence)
Recommended Name: Epithelial discoidin domain-containing receptor 1 precursor  
Size: 913 amino acids; 101128 Da
Subunit: Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a
tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine
phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11.
Interacts with NCK2
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 3: Secreted (Potential)
Subcellular location: Isoform 4: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=ACF47649.1; Type=Erroneous termination; Positions=287; Note=Translated as Cys;
Sequence=BAE06103.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for DDR1:
4AG4 (3D)    
Secondary accessions: B5A975 B5A976 B7Z2K0 Q14196 Q16562 Q2L6H3 Q4LE50 Q5ST11 Q5ST12 Q6NSK4 Q9UD35
Q9UD36 Q9UD37 Q9UD86 Q9UDL2
Alternative splicing: 5 isoforms:  Q08345-1   Q08345-2   Q08345-4   Q08345-5   Q08345-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDR1: NX_Q08345

Post-translational modifications:

  • Autophosphorylated in response to fibrillar collagen binding1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q08345

    • 4/16 DME Specific Peptides for DDR1 (Q08345) (see all 16)
     GDGAWCP  FVHRDLA  DPLCMIT  PPRGPGPP 

    DDR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (6 alternative transcripts): 
    NP_001189450.1  NP_001189451.1  NP_001189452.1  NP_001945.3  NP_054699.2  NP_054700.2  

    ENSEMBL proteins: 
     ENSP00000424346   ENSP00000421189   ENSP00000426420   ENSP00000318217   ENSP00000420833  
     ENSP00000421753   ENSP00000424468   ENSP00000427369   ENSP00000407699   ENSP00000422331  
     ENSP00000392413   ENSP00000424703   ENSP00000406091   ENSP00000425713   ENSP00000394273  
     ENSP00000379631   ENSP00000424758   ENSP00000426229   ENSP00000426799   ENSP00000422467  
     ENSP00000423492   ENSP00000423928   ENSP00000365753   ENSP00000425113   ENSP00000427597  
     ENSP00000390593   ENSP00000365752   ENSP00000421152   ENSP00000421978   ENSP00000422442  
     ENSP00000421719   ENSP00000409682   ENSP00000422108   ENSP00000423906   ENSP00000423749  
     ENSP00000422974   ENSP00000365751   ENSP00000427552   ENSP00000409400   ENSP00000398682  
     ENSP00000427124   ENSP00000424003   ENSP00000365759   ENSP00000365754   ENSP00000405039  
     ENSP00000405998   ENSP00000354844  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DDR1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): DDR1
    OriGene Protein Over-expression Lysate (see all 5): DDR1
    OriGene Custom Protein Services for DDR1 
    GenScript Custom Purified and Recombinant Proteins Services for DDR1
    Novus Biologicals DDR1 Proteins
    Novus Biologicals DDR1 Lysates
    Sino Biological Recombinant Protein for DDR1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DDR1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane TAS8390675
    GO:0016323basolateral plasma membrane ----


    DDR1 for ontologies           About GeneDecksing



    DDR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DDR1
    Cell Signaling Technology (CST) Antibodies for DDR1 
    OriGene Antibodies: DDR1
    OriGene Custom Antibody Services for DDR1 
    GenScript Custom Superior Antibodies Services for DDR1
    Novus Biologicals DDR1 Antibodies
    Abcam antibodies for DDR1 
    Uscn Antibodies for DDR1
    ThermoFisher Antibodies for DDR1

    Assay Products for DDR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for DDR1         (see all)
    GenScript Custom Assay Services for DDR1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for DDR1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DDR1

    Protein Domains /
    Families
    for DDR1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DDR1 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR011009 Kinase-like_dom
     IPR002011 Tyr_kinase_rcpt_2_CS
     IPR000719 Prot_kinase_cat_dom
     IPR008979 Galactose-bd-like
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q08345

    ProtoNet protein and cluster: Q08345

    3 Blocks protein families:
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB002011 Receptor tyrosine kinase
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
    Domain: The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 1 F5/8 type C domain
    Similarity: Contains 1 protein kinase domain


    Function
    for DDR1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
    Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment
    to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and
    cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP
    kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7
    and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during
    pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and
    normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound
    healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for DDR1:
    discoidin domains receptor family,member 1

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		miRTarBase miRNAs that target DDR1:
    hsa-mir-199a-5p (MIRT004674)

    OriGene 3'-UTR Clone (see all 3): DDR1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDR1
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DDR1 (see all 13):
    hsa-miR-194* hsa-miR-199a-5p hsa-miR-656 hsa-miR-1207-3p hsa-miR-199b-5p hsa-miR-542-3p hsa-miR-4302 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: DDR1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDR1 (see all 7)
    OriGene shRNA RFP: DDR1
    OriGene siRNA: DDR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDR1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DDR1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDR1 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDR1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): DDR1 (NM_013993)
    Sino Biological Human cDNA Clone for DDR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDR1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DDR1
    Search LifeMap BioReagents cell lines for DDR1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR1

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS9659899
    GO:0004872receptor activity ----
    GO:0005515protein binding IPI18190796
    GO:0005518collagen binding IMP12065315


    DDR1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for DDR1:
     Increased cell death HMECs cel  Increased cell death in breast  Synthetic lethal with cisplati 

    Animal Models:
         Mouse knock-out Ddr1tm1Wfv for DDR1
         14 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ddr1):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  renal/urinary system  reproductive system  skeleton 

    DDR1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DDR1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    4Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		CDC42 Pathway0.34
    		Actin Nucleation and Branching0.66
    5Akt Signaling
    		Akt Signaling1.00
    		p38 Signaling0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DDR1 (see all 30)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for DDR1
        Tyrosine Kinases / Adaptors



    DDR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/19 Interacting proteins for DDR1 (Q083452, 3 ENSP000004060914) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-74883 MINT-74885 MINT-74882 MINT-8035995 I2D: score=3 STRING: ENSP00000340944
    RGS2P412202, 3MINT-8268735 MINT-63731 I2D: score=5 
    SNAPINO952952, 3MINT-64069 I2D: score=5 
    SNRNP40Q96DI72, 3MINT-64071 I2D: score=5 
    TM4SF1P304082, 3MINT-63643 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0001952regulation of cell-matrix adhesion IEA--
    GO:0007155cell adhesion TAS8302582
    GO:0007566embryo implantation IEA--
    GO:0007595lactation IEA--


    DDR1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DDR1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DDR1 for compounds           About GeneDecksing

    EMD Millipore small molecules for DDR1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDR1

    2 HMDB Compounds for DDR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for DDR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ImatinibImatinib Mesylate (see all 3)152459-95-5targetantagonist16401709 16168515 15972446 16298518 15994946

    8 Novoseek chemical compound relationships for DDR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 71 93 16440311 (4), 18938156 (3), 16611743 (3), 12628922 (2) (see all 50)
    ribonucleic acid 28 5 11126911 (1), 17001518 (1)
    matrigel 27.2 3 17970783 (1), 17001518 (1)
    wortmannin 13.8 1 10872813 (1)
    cgmp 12.6 5 12571245 (1), 8663415 (1), 20487500 (1)
    atp 0 6 8385768 (1)
    calcium 0 8 8385768 (1), 17064702 (1)
    phosphatidylinositol 0 3 12471617 (1), 10872813 (1)

    Search CenterWatch for drugs/clinical trials and news about DDR1 

    Transcripts
    for DDR1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDR1 gene (6 alternative transcripts): 
    NM_001202521.1  NM_001202522.1  NM_001202523.1  NM_001954.4  NM_013993.2  NM_013994.2  

    Unigene Cluster for DDR1:

    Discoidin domain receptor tyrosine kinase 1
    Hs.631988  [show with all ESTs]
    Unigene Representative Sequence: NM_013993
    18/59 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 59):
    ENST00000502955 ENST00000505066 ENST00000460944 ENST00000324771(uc003nrr.3 uc003nrs.3)
    ENST00000505534 ENST00000513749 ENST00000503180 ENST00000508317 ENST00000482050
    ENST00000418800 ENST00000509639 ENST00000515529 ENST00000412274 ENST00000507901
    ENST00000454612(uc010jse.3 uc003nrq.3) ENST00000507046 ENST00000437124
    ENST00000396342

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): DDR1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDR1
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DDR1 (see all 13):
    hsa-miR-194* hsa-miR-199a-5p hsa-miR-656 hsa-miR-1207-3p hsa-miR-199b-5p hsa-miR-542-3p hsa-miR-4302 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: DDR1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDR1 (see all 7)
    OriGene shRNA RFP: DDR1
    OriGene siRNA: DDR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDR1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDR1 (see all 8)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDR1 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 6): DDR1 (NM_013993)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDR1 
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    Additional cDNA sequence: 

    AB210021.1 AF353182.1 AF353183.1 AK130776.1 AK291621.1 AK294793.1 AK295643.1 BC008716.2 
    BC013400.2 BC070070.1 EU826613.1 EU826614.1 L11315.1 L20817.1 L57508.1 X74979.1 
    Z29093.1 

    24/40 DOTS entries (see all 40):

    DT.100705281  DT.100815634  DT.99935384  DT.95158982  DT.75123383  DT.121354427  DT.102832990  DT.121354374 
    DT.100815626  DT.100815625  DT.92447581  DT.92050162  DT.95291688  DT.100815632  DT.121354367  DT.102832991 
    DT.121354412  DT.121354430  DT.95303275  DT.100815633  DT.121354409  DT.100815629  DT.121354388  DT.121354402 

    24/392 AceView cDNA sequences (see all 392):

    CB305834 CA488551 AA364485 BQ953137 BM702318 AW197078 CA495354 AL043251 
    BQ447333 BQ671817 AI382495 AL045220 CB129633 AA583577 CD519016 AA487526 
    AA487745 CA487269 AW860441 BQ448674 BM929712 AL539517 AF353183 CA448451 

    GeneLoc Exon Structure


    Expression
    for DDR1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCATTGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DDR1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Cardiomyocyte-like cells (Spontaneous differen...)

    See DDR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDR1

    SOURCE GeneReport for Unigene cluster: Hs.631988

    UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
    Tissue specificity: Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells,
    SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most
    adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in
    melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic
    mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed
    in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the
    surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules.
    Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin

        SABiosciences Custom PCR Arrays for DDR1
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    In Situ
    Assay Products:     
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    Orthologs
    for DDR1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DDR1 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia DDR16
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343438.1(572460-608771)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC690832 hypothetical protein MGC69083 76.26(n)    BC060755.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ddr11 discoidin domain receptor family, member 1 65.28(n)
    64.74(a)    		   100007346  XM_001345793.5  XP_001345829.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ddr6
    		 Discoidin domain receptor
    		 18(a)
    		 1 → many
    		 2L(6253123-6322251)
    worm
    (Caenorhabditis elegans)    		 Secernentea ddr-26
    cam-16
    		 Discoidin Domain Receptor family member (ddr-2)
    CAN cell Migration defective family member (cam-1)...
    		 31(a)
    14(a)
    		 1 ↔ many
    possible ortholog
    		 X(3315309-3324216)
    II(9295877-9310242)


    ENSEMBL Gene Tree for DDR1 (if available)
    TreeFam Gene Tree for DDR1 (if available) 

    Paralogs
    for DDR1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDR1 gene
    INSR2  ROR12  ROS12  NTRK22  LTK2  IGF1R2  NTRK32  ROR22  
    INSRR2  DDR22  MUSK2  ALK2  NTRK12  
    18/45 SIMAP similar genes for DDR1 using alignment to 44 protein entries:     DDR1_HUMAN (see all proteins) (see all similar genes):
    ABL1    DDR2    TXK    NTRK1    NTRK3    DKFZp686M05208
    MET    SRC    BTK kinase deficient isoform 6    EPHA2    DKFZp434L0319    DKFZp686D1354
    NRP2    PTK7    NRP1    CCDC6-RETa    CCDC6-RETc    EZR-ROS1

    DDR1 for paralogs           About GeneDecksing



    Genomic Variants
    for DDR1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/401 NCBI SNPs in DDR1 are shown (see all 401)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs283626091,2
    		F,--30849877(+) AGCTGC/GAGCTC 5 -- us2k11Minor allele frequency- G:0.06EA 120
    rs283626101,2
    		F,--30850028(+) CCTCAC/TATTTT 5 -- us2k13Minor allele frequency- T:0.00MN EA 1372
    rs1901098011,2
    		--30850040(+) TCAGCC/TGTTTC 1 -- us2k10--------
    rs1420451291,2
    		--30850071(+) AGCAGA/GCTGCC 1 -- us2k10--------
    rs12643291,2
    		C,F,--30850113(-) CCATCC/TCCTCC 5 -- us2k11Minor allele frequency- T:0.17NA 120
    rs131975611,2
    		H--30850132(+) CATTTG/TGGGGT 5 -- us2k14Minor allele frequency- T:0.00NS EA 406
    rs12643281,2
    		C,F,A,H,--30850142(-) GTCCCC/TGAGAA 3 -- us2k117Minor allele frequency- T:0.49NS EA NA WA CSA 912
    rs95010321,2
    		C,F,A,H,--30850191(+) TGGAAT/CGGGCT 4 -- us2k122Minor allele frequency- C:0.37NS EA NA WA CSA 2350
    rs30941081,2
    		C,F,A,--30850395(-) AGCTCC/TAGGCT 4 -- us2k113Minor allele frequency- T:0.19MN EA NA WA CSA 1624
    rs283626111,2
    		F,--30850436(+) TCTCCT/CGAGGC 10 -- us2k13Minor allele frequency- C:0.03MN EA 1372

    HapMap Linkage Disequilibrium report for DDR1 (30844198 - 30867933 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DDR1: --
    Human Gene Mutation Database (HGMD): DDR1

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    Disorders / Diseases
    for DDR1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DDR1 for disorders           About GeneDecksing

    OMIM gene information: 600408    OMIM disorders: --

    20/53 diseases for DDR1 (see all 53):    About MalaCards
    churg-strauss syndrome    non-small cell lung carcinoma    carcinoma    pulmonary fibrosis
    idiopathic pulmonary fibrosis    cervical squamous cell carcinoma    systemic lupus erythematosus    squamous cell carcinoma
    pancreatic endocrine tumors    lupus erythematosus    retinoschisis    acute lymphoblastic leukemia
    keloids    lymphoblastic leukemia    acute myeloid leukemia    pulmonary sarcoidosis
    pituitary adenoma    myeloid leukemia    lymphangioleiomyomatosis    malignant glioma

    10/19 Novoseek disease relationships for DDR1 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosis idiopathic pulmonary 44 5 16690978 (1), 16507902 (1), 15879152 (1), 16424224 (1)
    pediatric brain tumor 41.2 4 9075249 (2), 11126911 (1)
    pulmonary fibrosis 35.6 4 16690978 (2), 18065762 (1), 16424224 (1)
    keloid 32.4 3 17554880 (2), 11129182 (1)
    bronchoalveolar lavage fluid 31 4 15879152 (2), 18941260 (1), 16166739 (1)
    tumors 19.8 21 11126911 (5), 11606478 (2), 14500648 (1), 16440311 (1) (see all 10)
    glioblastoma multiforme 18.9 1 16234985 (1)
    breast cancer 11.3 5 15701836 (1), 17690741 (1), 16912190 (1), 11493640 (1) (see all 5)
    colon carcinoma 9.74 1 7845687 (1)
    cancer 9.43 7 17970783 (1), 17690741 (1), 7845687 (1), 16912190 (1) (see all 7)

    Genetic Association Database (GAD): DDR1
    Human Genome Epidemiology (HuGE) Navigator: DDR1 (11 documents)

    Export disorders for DDR1 gene to outside databases

    Publications
    for DDR1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDR1 gene, integrated from 9 sources (see all 177):
    (articles sorted by number of sources associating them with DDR1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis. (PubMed id 15213330)1, 4, 9 Zeggini E....Donn R. (2004)
    2. The genomic structure of discoidin receptor tyrosine kinase. (PubMed id 8796349)1, 2, 9 Playford M.P....Ganesan T.S. (1996)
    3. The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. (PubMed id 19401332)1, 2, 9 Huang Y....Vogel W.F. (2009)
    4. Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. (PubMed id 8977099)1, 2, 9 Sakuma S.... Abe H. (1996)
    5. KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. (PubMed id 18190796)1, 2, 9 Hilton H.N.... Ormandy C.J. (2008)
    6. Collagen stimulates discoidin domain receptor 1-media ted migration of smooth muscle cells through Src. (PubMed id 20093046)1, 2 Lu K.K....Bendeck M.P. (2011)
    7. Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. (PubMed id 21044884)1, 2 Xu H....Leitinger B. (2011)
    8. Discoidin domain receptor 1 regulates bronchial epith elial repair and matrix metalloproteinase production. (PubMed id 20884741)1, 2 Roberts M.E....Johnson S.R. (2011)
    9. Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464)1, 2 Jin P.... Paleolog E.M. (2008)
    10. Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1. (PubMed id 16337946)1, 2 Koo D.H....Vogel W.F. (2006)

    External Searches for DDR1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DDR1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 780 HGNC: 2730 AceView: DDR1 Ensembl:ENSG00000204580 euGenes: HUgn780
    ECgene: DDR1 H-InvDB: DDR1

    Other Databases showing DDR1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDR1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDR1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DDR1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDR1 gene:
    Search GeneIP for patents involving DDR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DDR1 gene

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    About This Section

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