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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDR1 Gene

protein-coding   GIFtS: 70
GCID: GC06P030848

Discoidin Domain Receptor Tyrosine Kinase 1

(Previous names: discoidin domain receptor family, member 1)
(Previous symbols: NTRK4, PTK3A, NEP, CAK, EDDR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Discoidin Domain Receptor Tyrosine Kinase 11 2     CD1672
NEP1 2 3 5     DDR2
CAK1 2 3     MCK102
EDDR11 2 3     PTK32
NTRK41 2 3     Epithelial Discoidin Domain-Containing Receptor 12
PTK3A1 2 3     Neuroepithelial Tyrosine Kinase2
TRKE2 3 5     Neurotrophic Tyrosine Kinase, Receptor, Type 42
Cell Adhesion Kinase2 3     PTK3A Protein Tyrosine Kinase 3A2
Mammary Carcinoma Kinase 102 3     MCK-103
Protein-Tyrosine Kinase RTK-62 3     CD167a Antigen3
Tyrosine Kinase DDR2 3     Discoidin Receptor Tyrosine Kinase3
Tyrosine-Protein Kinase CAK2 3     Epithelial Discoidin Domain Receptor 13
HGK22 3     Protein-Tyrosine Kinase 3A3
RTK62 3     TRK E3
CD167 Antigen-Like Family Member A2 3     ENTRK45
EC 2.7.10.13 8     EC 2.7.108
Discoidin Domain Receptor Family, Member 11     

External Ids:    HGNC: 27301   Entrez Gene: 7802   Ensembl: ENSG000002045807   OMIM: 6004085   UniProtKB: Q083453   

Export aliases for DDR1 gene to outside databases

Previous GC identifers: GC06P030907 GC06P030619 GC06P030959 GC06P030960 GC06P030631 GC06P030653


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDR1 Gene:
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases
are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene
belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I
in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is
restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition,
it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript
variants encoding different isoforms have been described for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for DDR1 Gene: 
DDR1 (discoidin domain receptor tyrosine kinase 1) is a protein-coding gene. Diseases associated with DDR1 include retinoschisis, and keloids, and among its related super-pathways are p53 Signaling and Ras Pathway. GO annotations related to this gene include collagen binding and protein tyrosine kinase collagen receptor activity. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell
attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation,
survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the
activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix
metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for
normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation.
Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and
thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11

Gene Wiki entry for DDR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167248.1  NC_018917.2  NT_167244.1  
NT_167247.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDR1 gene promoter:
         STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

DDR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDR1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030848:  view genomic region     (about GC identifiers)

Start:
30,844,198 bp from pter      End:
30,867,933 bp from pter
Size:
23,736 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167247 2,233,818-2,254,651      Chr6+,NT_167245 2,145,963-2,162,051      Chr6+,NT_167244 2,164,481-2,168,878     
Chr6+,NT_113891.2 2,363,959-2,380,033      Chr6+,NT_167246 2,199,946-2,216,014      Chr6+,NT_167248 2,144,848-2,160,922     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 (See protein sequence)
Recommended Name: Epithelial discoidin domain-containing receptor 1 precursor  
Size: 913 amino acids; 101128 Da
Subunit: Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms a
tripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine
phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11.
Interacts with NCK2
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Cell membrane; Single-pass type I membrane protein
Subcellular location: Isoform 3: Secreted (Potential)
Subcellular location: Isoform 4: Cell membrane; Single-pass type I membrane protein
Sequence caution: Sequence=ACF47649.1; Type=Erroneous termination; Positions=287; Note=Translated as Cys;
Sequence=BAE06103.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for DDR1:
3ZOS (3D)        4AG4 (3D)        4BKJ (3D)    
Secondary accessions: B5A975 B5A976 B7Z2K0 Q14196 Q16562 Q2L6H3 Q4LE50 Q5ST11 Q5ST12 Q6NSK4
Q9UD35 Q9UD36 Q9UD37 Q9UD86 Q9UDL2
Alternative splicing: 5 isoforms:  Q08345-1   Q08345-2   Q08345-4   Q08345-5   Q08345-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDR1: NX_Q08345

Explore proteomics data for DDR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Autophosphorylated in response to fibrillar collagen binding
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q08345

  • 4/16 DME Specific Peptides for DDR1 (Q08345) (see all 16)
     GDGAWCP  FVHRDLA  DPLCMIT  PPRGPGPP 

    DDR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDR1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001189450.1  NP_001189451.1  NP_001189452.1  NP_001945.3  NP_054699.2  NP_054700.2  

    ENSEMBL proteins: 
     ENSP00000424346   ENSP00000421189   ENSP00000426420   ENSP00000318217   ENSP00000420833  
     ENSP00000421753   ENSP00000424468   ENSP00000427369   ENSP00000407699   ENSP00000422331  
     ENSP00000392413   ENSP00000424703   ENSP00000425713   ENSP00000394273   ENSP00000406091  
     ENSP00000379631   ENSP00000424758   ENSP00000426229   ENSP00000426799   ENSP00000422467  
     ENSP00000423492   ENSP00000423928   ENSP00000425113   ENSP00000365753   ENSP00000427597  
     ENSP00000390593   ENSP00000365752   ENSP00000421152   ENSP00000421978   ENSP00000422442  
     ENSP00000421719   ENSP00000409682   ENSP00000422108   ENSP00000423906   ENSP00000423749  
     ENSP00000422974   ENSP00000365751   ENSP00000427552   ENSP00000409400   ENSP00000398682  
     ENSP00000427124   ENSP00000424003   ENSP00000365759   ENSP00000365754   ENSP00000405039  
     ENSP00000405998   ENSP00000354844  
    Reactome Protein details: Q08345
    Human Recombinant Protein Products for DDR1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DDR1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for DDR1
    OriGene Protein Over-expression Lysate for DDR1
    OriGene MassSpec for DDR1 
    OriGene Custom Protein Services for DDR1
    GenScript Custom Purified and Recombinant Proteins Services for DDR1
    Novus Biologicals DDR1 Proteins
    Novus Biologicals DDR1 Lysates
    Sino Biological Recombinant Protein for DDR1
    Sino Biological Cell Lysate for DDR1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDR1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8390675

    DDR1 for ontologies           About GeneDecksing



    DDR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DDR1
    Cell Signaling Technology (CST) Antibodies for DDR1 
    OriGene Antibodies for DDR1
    OriGene Custom Antibody Services for DDR1
    GenScript Custom Superior Antibodies Services for DDR1
    Novus Biologicals DDR1 Antibodies
    Abcam antibodies for DDR1
    Cloud-Clone Corp. Antibodies for DDR1 
    ThermoFisher Antibody for DDR1
    LSBio Antibodies in human, mouse, rat for DDR1 

    Assay Products for DDR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDR1
    R&D Systems ELISAs for DDR1         (see all)
    GenScript Custom Assay Services for DDR1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for DDR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDR1 
    Cloud-Clone Corp. CLIAs for DDR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    IUPHAR Guide to PHARMACOLOGY protein family classification: discoidin domain receptor tyrosine kinase 1 
    DDR (collagen receptor) family
    DDR (collagen receptor) family

    5/8 InterPro protein domains (see all 8):
     IPR011009 Kinase-like_dom
     IPR002011 Tyr_kinase_rcpt_2_CS
     IPR000719 Prot_kinase_cat_dom
     IPR008979 Galactose-bd-like
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q08345

    ProtoNet protein and cluster: Q08345

    3 Blocks protein domains:
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB002011 Receptor tyrosine kinase
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
    Domain: The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 1 F5/8 type C domain
    Similarity: Contains 1 protein kinase domain


    DDR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDR1_HUMAN, Q08345
    Function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell
    attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation,
    survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the
    activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix
    metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for
    normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation.
    Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and
    thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for DDR1:
    discoidin domains receptor family,member 1

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity TAS9659899
    GO:0005515protein binding IPI16337946
    GO:0005518collagen binding IMP12065315
         
    DDR1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DDR1:
     Increased cell death HMECs cel  Increased cell death in breast  Synthetic lethal with cisplati 

         14 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ddr1):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system 
     integument  renal/urinary system  reproductive system  skeleton 

    DDR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ddr1tm1Wfv for DDR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDR1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDR1:
    hsa-mir-199a-5p (MIRT004674)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDR1
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DDR1 (see all 13):
    hsa-miR-194* hsa-miR-199a-5p hsa-miR-656 hsa-miR-1207-3p hsa-miR-199b-5p hsa-miR-542-3p hsa-miR-4302 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidDDR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDR1
    Sirion Biotech Customized adenovirus for overexpression of DDR1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DDR1 (see all 23)
    OriGene ORF clones in mouse, rat for DDR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): DDR1 (NM_013993)
    Sino Biological Human cDNA Clone for DDR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDR1
    Sirion Biotech Customized lentivirus for stable overexpression of DDR1 
                         Customized lentivirus expression plasmids for stable overexpression of DDR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDR1
    Search LifeMap BioReagents cell lines for DDR1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DDR1 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1p53 Pathway
    p53 Signaling0.38
    p53 Pathway0.38
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    4Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    CDC42 Pathway0.41
    Actin Nucleation and Branching0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DDR1 (see all 30)
        MAPK Signaling
    Paxillin Interactions
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling

    1 Cell Signaling Technology (CST) Pathway for DDR1
        Tyrosine Kinases / Adaptors

    1 Sino Biological Pathway for DDR1 
        p53 Pathway

    2        Reactome Pathways for DDR1
        Extracellular matrix organization
    Non-integrin membrane-ECM interactions



    DDR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/19 Interacting proteins for DDR1 (Q083452, 3 ENSP000004060914) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN11Q061242, 3, ENSP000003409444MINT-74883 MINT-74885 MINT-74882 MINT-8035995 I2D: score=3 STRING: ENSP00000340944
    RGS2P412202, 3MINT-8268735 MINT-63731 I2D: score=5 
    SNAPINO952952, 3MINT-64069 I2D: score=5 
    SNRNP40Q96DI72, 3MINT-64071 I2D: score=5 
    TM4SF1P304082, 3MINT-63643 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0001952regulation of cell-matrix adhesion IEA--
    GO:0006468protein phosphorylation ----
    GO:0007155cell adhesion TAS8302582
    GO:0007566embryo implantation IEA--

    DDR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DDR1 for compounds           About GeneDecksing

    EMD Millipore small molecules for DDR1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDR1

    2 HMDB Compounds for DDR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for DDR1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ImatinibCGP-57148B (see all 4)152459-95-5targetantagonist16401709 16168515 15972446 16298518 15994946

    8 Novoseek inferred chemical compound relationships for DDR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 71 93 16440311 (4), 18938156 (3), 16611743 (3), 12628922 (2) (see all 50)
    ribonucleic acid 28 5 11126911 (1), 17001518 (1)
    matrigel 27.2 3 17970783 (1), 17001518 (1)
    wortmannin 13.8 1 10872813 (1)
    cgmp 12.6 5 12571245 (1), 8663415 (1), 20487500 (1)
    atp 0 6 8385768 (1)
    calcium 0 8 8385768 (1), 17064702 (1)
    phosphatidylinositol 0 3 12471617 (1), 10872813 (1)

    Search CenterWatch for drugs/clinical trials and news about DDR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDR1 gene (6 alternative transcripts): 
    NM_001202521.1  NM_001202522.1  NM_001202523.1  NM_001954.4  NM_013993.2  NM_013994.2  

    Unigene Cluster for DDR1:

    Discoidin domain receptor tyrosine kinase 1
    Hs.631988  [show with all ESTs]
    Unigene Representative Sequence: NM_013993
    18/59 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 59):
    ENST00000502955 ENST00000505066 ENST00000460944 ENST00000324771(uc003nrr.3 uc003nrs.3)
    ENST00000505534 ENST00000513749 ENST00000503180 ENST00000508317 ENST00000482050
    ENST00000418800 ENST00000509639 ENST00000515529 ENST00000412274 ENST00000507901
    ENST00000507046 ENST00000437124 ENST00000454612(uc010jse.3 uc003nrq.3)
    ENST00000396342
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDR1
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DDR1 (see all 13):
    hsa-miR-194* hsa-miR-199a-5p hsa-miR-656 hsa-miR-1207-3p hsa-miR-199b-5p hsa-miR-542-3p hsa-miR-4302 hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidDDR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDR1
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    Additional mRNA sequence: 

    AB210021.1 AF353182.1 AF353183.1 AK130776.1 AK291621.1 AK294793.1 AK295643.1 BC008716.2 
    BC013400.2 BC070070.1 EU826613.1 EU826614.1 L11315.1 L20817.1 L57508.1 X74979.1 
    Z29093.1 

    24/40 DOTS entries (see all 40):

    DT.100705281  DT.100815634  DT.99935384  DT.95158982  DT.75123383  DT.121354427  DT.102832990  DT.121354374 
    DT.100815626  DT.100815625  DT.92447581  DT.92050162  DT.95291688  DT.100815632  DT.121354367  DT.102832991 
    DT.121354412  DT.121354430  DT.95303275  DT.100815633  DT.121354409  DT.100815629  DT.121354388  DT.121354402 

    24/392 AceView cDNA sequences (see all 392):

    BM702318 AW860441 AA425346 CA488551 BM142574 AA746483 AA487526 CB851548 
    BM262997 AI813770 AA583577 AI567223 BQ933041 BQ279169 CA489498 AW498978 
    AW591308 NM_001954 BQ919243 AI821641 AI342378 CA487269 BU685006 AF353183 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDR1 expression in normal human tissues (normalized intensities)      DDR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCATTGGA
    DDR1 Expression
    About this image


    DDR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Hippocampus
             Olfactory Bulb   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             pre Conventional Dendritic Cells Peripheral Blood
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e16.5   
     
     Lung (Respiratory System)
             trachea   
     
     Spinal Cord (Nervous System)
             Ventral Horn   

    See DDR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDR1

    SOURCE GeneReport for Unigene cluster: Hs.631988

    UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
    Tissue specificity: Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma
    cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low
    levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression
    are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines.
    In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the
    thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of
    Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in
    the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue,
    muscle cells or cells of hematopoietic origin

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DDR1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddr11 , 5 discoidin domain receptor family, member 11, 5 87.75(n)1
    93.95(a)1
      17 (18.70 cM)5
    123051  NM_007584.21  NP_031610.11 
     356815675 
    lizard
    (Anolis carolinensis)
    Reptilia DDR16
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343438.1(568113-608771)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690832 hypothetical protein MGC69083 76.26(n)    BC060755.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ddr11 discoidin domain receptor family, member 1 65.28(n)
    64.74(a)
      100007346  XM_001345793.5  XP_001345829.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ddr6
    CG343806
    --
    28(a)
    23(a)
    many ↔ many
    many ↔ many
    2L(6253123-6322251)
    2L(6179133-6211114)
    worm
    (Caenorhabditis elegans)
    Secernentea ddr-26
    ddr-16
    Protein DDR-1
    31(a)
    19(a)
    many ↔ many
    many ↔ many
    X(3315321-3324229)
    X(5461256-5466063)


    ENSEMBL Gene Tree for DDR1 (if available)
    TreeFam Gene Tree for DDR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDR1 gene
    ROR12  INSR2  ROS12  NTRK22  LTK2  IGF1R2  PTK72  NTRK32  
    INSRR2  ROR22  DDR22  MUSK2  ALK2  NTRK12  
    18/59 SIMAP similar genes for DDR1 using alignment to 36 protein entries:     DDR1_HUMAN (see all proteins) (see all similar genes):
    ABL1    NTRK1    NTRK3    DKFZp686M05208    DDR2    TXK
    BTK kinase deficient isoform 6    EPHA2    EZR-ROS1    FGFR4    LRIG3(NM_001136051)-ROS1    LRIG3(NM_153377)-ROS1
    R32    R34    SLC34A2-ROS1    TPM3-ROS1    NRP1    CCDC6-RETa

    DDR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/511 SNPs in DDR1 are shown (see all 511)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0414974
    A lung squamous cell carcinoma sample4--see VAR_0414972 S A mis40--------
    rs283626091,2
    F--30766753(+) AGCTGC/GAGCTC 1 -- us2k11Minor allele frequency- G:0.06EA 120
    rs283626101,2
    C,F--30766904(+) CCTCAC/TATTTT 1 -- us2k13Minor allele frequency- T:0.00MN EA 1372
    rs1901098011,2
    --30766916(+) TCAGCC/TGTTTC 1 -- us2k10--------
    rs1420451291,2
    --30766947(+) AGCAGA/GCTGCC 1 -- us2k10--------
    rs12643291,2
    C,F--30766989(-) CCATCC/TCCTCC 1 -- us2k11Minor allele frequency- T:0.17NA 120
    rs131975611,2
    H--30767008(+) CATTTG/TGGGGT 1 -- us2k14Minor allele frequency- T:0.00NS EA 406
    rs12643281,2
    C,F,A,H--30767018(-) GTCCCC/TGAGAA 1 -- us2k117Minor allele frequency- T:0.49NS EA NA WA CSA 912
    rs95010321,2
    C,F,A,H--30767067(+) TGGAAT/CGGGCT 1 -- us2k122Minor allele frequency- C:0.37NS EA NA WA CSA 2350
    rs30941081,2
    C,F,A--30767271(-) AGCTCC/TAGGCT 2 -- us2k113Minor allele frequency- T:0.19MN EA NA WA CSA 1624

    HapMap Linkage Disequilibrium report for DDR1 (30844198 - 30867933 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for DDR1 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670269CNV Deletion23128226
    esv2731791CNV Deletion23290073
    nsv5245CNV Insertion18451855
    dgv6533n71CNV Loss21882294
    dgv6532n71CNV Loss21882294
    dgv6531n71CNV Loss21882294
    nsv884122CNV Loss21882294
    dgv6534n71CNV Loss21882294
    dgv6530n71CNV Loss21882294
    nsv525438CNV Gain19592680


    Human Gene Mutation Database (HGMD): DDR1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600408    OMIM disorders: --

    20/49 diseases for DDR1 (see all 49):    About MalaCards
    retinoschisis    keloids    churg-strauss syndrome    lymphangioleiomyomatosis
    pulmonary fibrosis    pulmonary sarcoidosis    pancreatic endocrine tumor    cervical squamous cell carcinoma
    idiopathic pulmonary fibrosis    vitiligo    sarcoidosis    non-small cell lung carcinoma
    pituitary adenoma    esophageal cancer    malignant glioma    atherosclerosis
    glioblastoma    nasopharyngitis    acute myeloid leukemia    acute lymphoblastic leukemia


    DDR1 for disorders           About GeneDecksing

    10/19 Novoseek inferred disease relationships for DDR1 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosis idiopathic pulmonary 44 5 16690978 (1), 16507902 (1), 15879152 (1), 16424224 (1)
    pediatric brain tumor 41.2 4 9075249 (2), 11126911 (1)
    pulmonary fibrosis 35.6 4 16690978 (2), 18065762 (1), 16424224 (1)
    keloid 32.4 3 17554880 (2), 11129182 (1)
    bronchoalveolar lavage fluid 31 4 15879152 (2), 18941260 (1), 16166739 (1)
    tumors 19.8 21 11126911 (5), 11606478 (2), 14500648 (1), 16440311 (1) (see all 10)
    glioblastoma multiforme 18.9 1 16234985 (1)
    breast cancer 11.3 5 15701836 (1), 17690741 (1), 16912190 (1), 11493640 (1) (see all 5)
    colon carcinoma 9.74 1 7845687 (1)
    cancer 9.43 7 17970783 (1), 17690741 (1), 7845687 (1), 16912190 (1) (see all 7)

    Genetic Association Database (GAD): DDR1
    Human Genome Epidemiology (HuGE) Navigator: DDR1 (11 documents)

    Export disorders for DDR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDR1 gene, integrated from 9 sources (see all 190):
    (articles sorted by number of sources associating them with DDR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis. (PubMed id 15213330)1, 4, 9 Zeggini E....Donn R. (2004)
    2. The genomic structure of discoidin receptor tyrosine kinase. (PubMed id 8796349)1, 2, 9 Playford M.P....Ganesan T.S. (1996)
    3. Linkage and association study of discoidin domain rec eptor 1 as a novel susceptibility gene for childhood IgA nephropathy. (PubMed id 20372823)1, 4, 9 Hahn W.H....Kim S.D. (2010)
    4. The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. (PubMed id 19401332)1, 2, 9 Huang Y....Vogel W.F. (2009)
    5. The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia. (PubMed id 17440435)1, 4, 9 Roig B....Vilella E. (2007)
    6. Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. (PubMed id 8977099)1, 2, 9 Sakuma S.... Abe H. (1996)
    7. KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. (PubMed id 18190796)1, 2, 9 Hilton H.N.... Ormandy C.J. (2008)
    8. Collagen stimulates discoidin domain receptor 1-media ted migration of smooth muscle cells through Src. (PubMed id 20093046)1, 2 Lu K.K....Bendeck M.P. (2011)
    9. Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. (PubMed id 21044884)1, 2 Xu H....Leitinger B. (2011)
    10. Discoidin domain receptor 1 regulates bronchial epith elial repair and matrix metalloproteinase production. (PubMed id 20884741)1, 2 Roberts M.E....Johnson S.R. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 780 HGNC: 2730 AceView: DDR1 Ensembl:ENSG00000204580 euGenes: HUgn780
    ECgene: DDR1 H-InvDB: DDR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDR1 gene:
    Search GeneIP for patents involving DDR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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