DDR1 Gene
protein-coding GIFtS : 66
GCID: GC06 P030848
discoidin domain receptor tyrosine kinase 1 (Previous names: discoidin domain receptor family, member 1 ) (Previous symbols: NTRK4, PTK3A, NEP, CAK, EDDR1 )
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Aliasesfor DDR1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Discoidin Domain Receptor Tyrosine Kinase 1 1 2 Discoidin Domain Receptor Family, Member 11 NEP1 2 3 5 DDR2 CAK1 2 3 MCK102 EDDR11 2 3 PTK32 NTRK41 2 3 Epithelial Discoidin Domain-Containing Receptor 12 PTK3A1 2 3 Neuroepithelial Tyrosine Kinase2 RTK61 2 3 Neurotrophic Tyrosine Kinase, Receptor, Type 42 TRKE2 3 5 PTK3A Protein Tyrosine Kinase 3A2 CD1671 2 MCK-103 Cell Adhesion Kinase2 3 CD167a Antigen3 Mammary Carcinoma Kinase 102 3 Discoidin Receptor Tyrosine Kinase3 Protein-Tyrosine Kinase RTK-62 3 Epithelial Discoidin Domain Receptor 13 Tyrosine Kinase DDR2 3 Protein-Tyrosine Kinase 3A3 Tyrosine-Protein Kinase CAK2 3 TRK E3 HGK22 3 ENTRK45 CD167 Antigen-Like Family Member A2 3 EC 2.7.108 EC 2.7.10.13 8
Export aliases for DDR1 gene to outside databases Previous GC identifers: GC06P030907 GC06P030619 GC06P030959 GC06P030960 GC06P030631 GC06P030653
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Summariesfor DDR1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DDR1 : Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. (provided by RefSeq, Feb 2011) UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 Function : Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachmentto the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11 Gene Wiki entry for DDR1
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Genomic Viewsfor DDR1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DDR1 gene promoter: STAT3 Other transcription factors Search SABiosciences Chromatin IP Primers for DDR1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDR1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33 DDR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P030848: view genomic region
(about GC identifiers )
Start:
30,844,198 bp from pter
End:
30,867,933 bp from pter
Size:
23,736 bases
Orientation:
plus strand
6 alternative locations : Chr 6+,ALT_REF_LOCI_3 30,839,458-30,869,692 Chr 6+,ALT_REF_LOCI_4 30,819,605-30,835,673 Chr 6+,ALT_REF_LOCI_2 30,838,646-30,897,017 Chr 6+,ALT_REF_LOCI_5 30,845,241-30,866,077 Chr 6+,ALT_REF_LOCI_1 30,861,248-30,873,781 Chr 6+,ALT_REF_LOCI_6 30,838,342-30,893,106
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Proteinsfor DDR1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 (See
protein sequence )Recommended Name: Epithelial discoidin domain-containing receptor 1 precursor Size : 913 amino acids; 101128 Da
Subunit : Homodimer. Interacts (via PPxY motif) with WWC1 (via WW domains) in a collagen-regulated manner. Forms atripartite complex with WWC1 and PRKCZ, but predominantly in the absence of collagen. Interacts (tyrosine phosphorylated) with SHC1. Interacts with SRC. Interacts with MYH9. Interacts with CDH1. Interacts with PTPN11. Interacts with NCK2
Subcellular location : Isoform 1: Cell membrane; Single-pass type I membrane protein
Subcellular location : Isoform 2: Cell membrane; Single-pass type I membrane protein
Subcellular location : Isoform 3: Secreted (Potential)
Subcellular location : Isoform 4: Cell membrane; Single-pass type I membrane protein
Sequence caution : Sequence=ACF47649.1; Type=Erroneous termination; Positions=287; Note=Translated as Cys;Sequence=BAE06103.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for DDR1 :4AG4 (3D)
 
Secondary accessions : B5A975 B5A976 B7Z2K0 Q14196 Q16562 Q2L6H3 Q4LE50 Q5ST11 Q5ST12 Q6NSK4 Q9UD35Q9UD36 Q9UD37 Q9UD86 Q9UDL2 Alternative splicing : 5 isoforms : Q08345-1 Q08345-2 Q08345-4 Q08345-5 Q08345-6 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DDR1: NX_Q08345 Post-translational modifications:
Autophosphorylated in response to fibrillar collagen binding1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q08345 4/16 DME Specific Peptides for DDR1 (Q08345 ) (see all 16 )DDR1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (6 alternative transcripts):
NP_001189450.1 NP_001189451.1 NP_001189452.1 NP_001945.3 NP_054699.2 NP_054700.2 ENSEMBL proteins: ENSP00000424346 ENSP00000421189 ENSP00000426420 ENSP00000318217 ENSP00000420833 ENSP00000421753 ENSP00000424468 ENSP00000427369 ENSP00000407699 ENSP00000422331 ENSP00000392413 ENSP00000424703 ENSP00000406091 ENSP00000425713 ENSP00000394273 ENSP00000379631 ENSP00000424758 ENSP00000426229 ENSP00000426799 ENSP00000422467 ENSP00000423492 ENSP00000423928 ENSP00000365753 ENSP00000425113 ENSP00000427597 ENSP00000390593 ENSP00000365752 ENSP00000421152 ENSP00000421978 ENSP00000422442 ENSP00000421719 ENSP00000409682 ENSP00000422108 ENSP00000423906 ENSP00000423749 ENSP00000422974 ENSP00000365751 ENSP00000427552 ENSP00000409400 ENSP00000398682 ENSP00000427124 ENSP00000424003 ENSP00000365759 ENSP00000365754 ENSP00000405039 ENSP00000405998 ENSP00000354844 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
DDR1 for ontologies About GeneDecksing DDR1 Antibody Products: Assay Products for DDR1:
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Protein
Domains / Familiesfor DDR1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DDR1 for domains About GeneDecksing 5/8 InterPro domains/families (see all 8 ):
Graphical View of Domain Structure for InterPro Entry Q08345 ProtoNet protein and cluster: Q08345
3 Blocks protein families : IPB000421 Coagulation factor 5/8 type C domain (FA58C) IPB002011 Receptor tyrosine kinase IPB008266 Tyrosine protein kinase UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 Domain : The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substratesSimilarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamilySimilarity : Contains 1 F5/8 type C domainSimilarity : Contains 1 protein kinase domain
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Functionfor DDR1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 Function : Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachmentto the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11 Catalytic activity : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Genatlas biochemistry entry for DDR1 : discoidin domains receptor family,member 1 Enzyme Numbers (IUBMB): EC 2.7.10.1 1 2 EC 2.7.10 2 Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDR1 (see all 8 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDR1 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 6 ): DDR1 (NM_013993 ) Sino Biological Human cDNA Clone for DDR1 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDR1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDR1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR1
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8 ): About this table
DDR1 for ontologies About GeneDecksing 3 GenomeRNAi human phenotypes for DDR1 :Animal Models: Mouse knock-out Ddr1 tm1Wfv for DDR1 14 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ddr1) :
DDR1 for phenotypes About GeneDecksing
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Pathways & Interactionsfor DDR1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/12 super-pathways (see all 12 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 GPCR Pathway 2 Rho Family GTPases 3 Nanog in Mammalian ESC Pluripotency 4 Actin Nucleation by ARP-WASP Complex 5 Akt Signaling
Pathway sources See GeneCards unified pathways Show all pathways 5/30 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DDR1 (see all 30 )1
Cell Signaling Technology (CST) Pathway for DDR1
DDR1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDR1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)5/19 Interacting proteins for DDR1 (Q08345 2 , 3 ENSP00000406091 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 19 )About this table Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19 ): About this table
DDR1 for ontologies About GeneDecksing
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Drugs & Compoundsfor DDR1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
DDR1 for compounds About GeneDecksing Browse Tocris compounds for DDR1 2 HMDB Compounds for DDR1 About this table 1 DrugBank Compound for DDR1 About this table 8 Novoseek chemical compound relationships for DDR1 gene About this table
Search CenterWatch for drugs/clinical trials and news about DDR1
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Transcriptsfor DDR1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DDR1 gene (6 alternative transcripts): NM_001202521.1 NM_001202522.1 NM_001202523.1 NM_001954.4 NM_013993.2 NM_013994.2 Unigene Cluster for DDR1:
Discoidin domain receptor tyrosine kinase 1 Hs.631988 [show with all ESTs ] Unigene Representative Sequence: NM_013993 18/59 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 59 ): ENST00000502955 ENST00000505066 ENST00000460944 ENST00000324771 (uc003nrr.3 uc003nrs.3 )ENST00000505534 ENST00000513749 ENST00000503180 ENST00000508317 ENST00000482050 ENST00000418800 ENST00000509639 ENST00000515529 ENST00000412274 ENST00000507901 ENST00000454612 (uc010jse.3 uc003nrq.3 ) ENST00000507046 ENST00000437124 ENST00000396342 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDR1 (see all 8 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDR1 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 6 ): DDR1 (NM_013993 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDR1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDR1
Additional cDNA sequence: AB210021.1 AF353182.1 AF353183.1 AK130776.1 AK291621.1 AK294793.1 AK295643.1 BC008716.2 BC013400.2 BC070070.1 EU826613.1 EU826614.1 L11315.1 L20817.1 L57508.1 X74979.1 Z29093.1
24/40 DOTS entries (see all 40 ): DT.100705281 DT.100815634
DT.99935384 DT.95158982 DT.75123383 DT.121354427 DT.102832990 DT.121354374 DT.100815626 DT.100815625 DT.92447581 DT.92050162 DT.95291688 DT.100815632 DT.121354367 DT.102832991 DT.121354412 DT.121354430 DT.95303275 DT.100815633 DT.121354409 DT.100815629 DT.121354388 DT.121354402 24/392 AceView cDNA sequences (see all 392 ):
CB305834 CA488551 AA364485 BQ953137 BM702318 AW197078 CA495354 AL043251 BQ447333 BQ671817 AI382495 AL045220 CB129633 AA583577 CD519016 AA487526 AA487745 CA487269 AW860441 BQ448674 BM929712 AL539517 AF353183 CA448451 GeneLoc Exon Structure
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Expression for DDR1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DDR1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCCCATTGGA
About this image DDR1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Heart Endocardium Cushion Mesenchymal Cells Endocardium Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category Cardiomyocyte-like cells (Spontaneous differen... )
See DDR1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DDR1 SOURCE GeneReport for Unigene cluster: Hs.631988 UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 Tissue specificity : Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells,SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not expressed in connective tissue, endothelial cells, adipose tissue, muscle cells or cells of hematopoietic origin SABiosciences Custom PCR Arrays for DDR1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DDR1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DDR1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DDR1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DDR1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR1
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Orthologsfor DDR1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for DDR1 gene from 5/18 species (see all 18 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
lizard (Anolis carolinensis)
Reptilia
DDR16
--
68(a)
1 ↔ 1
GL343438.1(572460-608771)
African clawed frog (Xenopus laevis)
Amphibia
MGC690832
hypothetical protein MGC69083
76.26(n)
 
BC060755.1
zebrafish (Danio rerio)
Actinopterygii
ddr11
discoidin domain receptor family, member 1
65.28(n) 64.74(a)
 
100007346 XM_001345793.5 XP_001345829.4
fruit fly (Drosophila melanogaster)
Insecta
Ddr6
Discoidin domain receptor
18(a)
1 → many
2L(6253123-6322251)
worm (Caenorhabditis elegans)
Secernentea
ddr-26 cam-16
Discoidin Domain Receptor family member (ddr-2)CAN cell Migration defective family member (cam-1)...
31(a) 14(a)
1 ↔ manypossible ortholog
X(3315309-3324216) II(9295877-9310242)
ENSEMBL Gene Tree for DDR1 (if available)TreeFam Gene Tree for DDR1 (if available)
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Paralogsfor DDR1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DDR1 gene INSR 2 ROR1 2 ROS1 2 NTRK2 2 LTK 2 IGF1R 2 NTRK3 2 ROR2 2 INSRR 2 DDR2 2 MUSK 2 ALK 2 NTRK1 2 18/45 SIMAP similar genes for DDR1 using alignment to 44 protein entries: DDR1_HUMAN (see all proteins )
(see all similar genes ):ABL1 DDR2 TXK NTRK1 NTRK3 DKFZp686M05208 MET SRC BTK kinase deficient isoform 6 EPHA2 DKFZp434L0319 DKFZp686D1354 NRP2 PTK7 NRP1 CCDC6-RETa CCDC6-RETc EZR-ROS1
DDR1 for paralogs About GeneDecksing
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Genomic Variantsfor DDR1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DDR1 (30844198 - 30867933 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DDR1: -- Human Gene Mutation Database (HGMD) : DDR1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DDR1
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Disorders
/ Diseasesfor DDR1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DDR1 for disorders About GeneDecksing
OMIM gene information: 600408
OMIM disorders : --20/53 diseases for DDR1 (see all 53 ): About MalaCards churg-strauss syndrome non-small cell lung carcinoma carcinoma pulmonary fibrosis idiopathic pulmonary fibrosis cervical squamous cell carcinoma systemic lupus erythematosus squamous cell carcinoma pancreatic endocrine tumors lupus erythematosus retinoschisis acute lymphoblastic leukemia keloids lymphoblastic leukemia acute myeloid leukemia pulmonary sarcoidosis pituitary adenoma myeloid leukemia lymphangioleiomyomatosis malignant glioma 10/19 Novoseek disease relationships for DDR1 gene (see all 19 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
fibrosis idiopathic pulmonary
44
5
16690978 (1), 16507902 (1), 15879152 (1), 16424224 (1)
pediatric brain tumor
41.2
4
9075249 (2), 11126911 (1)
pulmonary fibrosis
35.6
4
16690978 (2), 18065762 (1), 16424224 (1)
keloid
32.4
3
17554880 (2), 11129182 (1)
bronchoalveolar lavage fluid
31
4
15879152 (2), 18941260 (1), 16166739 (1)
tumors
19.8
21
11126911 (5), 11606478 (2), 14500648 (1), 16440311 (1) (see all 10 )
glioblastoma multiforme
18.9
1
16234985 (1)
breast cancer
11.3
5
15701836 (1), 17690741 (1), 16912190 (1), 11493640 (1) (see all 5 )
colon carcinoma
9.74
1
7845687 (1)
cancer
9.43
7
17970783 (1), 17690741 (1), 7845687 (1), 16912190 (1) (see all 7 )
Genetic Association Database (GAD): DDR1 Human Genome Epidemiology (HuGE) Navigator: DDR1 (11 documents) Export disorders for DDR1 gene to outside databases
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Publicationsfor DDR1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DDR1 gene, integrated from 9 sources (see all 177 ): (articles sorted by number of sources associating them with DDR1) Utopia : connect your pdf to the dynamic world of online information
Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis. (PubMed id 15213330) 1 , 4, 9 Zeggini E....Donn R. (2004) The genomic structure of discoidin receptor tyrosine kinase. (PubMed id 8796349) 1 , 2 , 9 Playford M.P....Ganesan T.S. (1996) The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA. (PubMed id 19401332) 1 , 2 , 9 Huang Y....Vogel W.F. (2009) Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. (PubMed id 8977099) 1 , 2 , 9 Sakuma S.... Abe H. (1996) KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling. (PubMed id 18190796) 1 , 2 , 9 Hilton H.N.... Ormandy C.J. (2008) Collagen stimulates discoidin domain receptor 1-media ted migration of smooth muscle cells through Src. (PubMed id 20093046) 1 , 2 Lu K.K....Bendeck M.P. (2011) Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1. (PubMed id 21044884) 1 , 2 Xu H....Leitinger B. (2011) Discoidin domain receptor 1 regulates bronchial epith elial repair and matrix metalloproteinase production. (PubMed id 20884741) 1 , 2 Roberts M.E....Johnson S.R. (2011) Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464) 1 , 2 Jin P.... Paleolog E.M. (2008) Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1. (PubMed id 16337946) 1 , 2 Koo D.H....Vogel W.F. (2006)
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External Searches for DDR1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DDR1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing DDR1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DDR1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for DDR1 gene: Search GeneIP for patents involving DDR1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DDR1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for DDR1 OriGene shRNA RFP for DDR1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DDR1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DDR1 OriGene Protein Over-expression Lysate for DDR1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DDR1 OriGene 3'-UTR Clone for DDR1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDR1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDR1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for DDR1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DDR1 OriGene Custom Protein Services for DDR1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDR1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DDR1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDR1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DDR1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DDR1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DDR1
Antibodies & Assays for DDR1  
Search Tocris compounds for DDR1
DDR1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDR1
ThermoFisher Antibodies for DDR1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDR1
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