DDR1 Gene
protein-coding GIFtS : 65
GC06P030960
discoidin domain receptor tyrosine kinase 1 (Previous names: discoidin domain receptor family, member 1 )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: NTRK4, PTK3A, NEP, CAK, EDDR1 )
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Aliases & Descriptions for DDR1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CAK 2 , 3 CD167 1 , 2 DDR 2 EC 2.7.10.1 3 EDDR1 2 , 3 HGK2 3 MCK10 2 NEP 2 , 3 NTRK4 2 , 3 OTTHUMP00000029343 2 OTTHUMP00000029344 2 OTTHUMP00000029345 2 OTTHUMP00000029346 2 OTTHUMP00000029347 2 PTK3 2 PTK3A 2 , 3 RTK6 1 , 2 , 3 TRKE 2 , 3
Descriptions CD167 antigen-like family member A 3 CD167a antigen 3 Cell adhesion kinase 2 , 3 Discoidin receptor tyrosine kinase 2 , 3 Epithelial discoidin domain receptor 1 2 , 3 PTK3A protein tyrosine kinase 3A 2 Protein-tyrosine kinase RTK 6 3 TRK E 3 Tyrosine kinase DDR 3 Tyrosine-protein kinase CAK 3 discoidin domain receptor family, member 1 1 , 2 discoidin domain receptor tyrosine kinase 1 2 mammarian carcinoma kinase 10 2 neuroepithelial tyrosine kinase 2 neurotrophic tyrosine kinase, receptor, type 4 2
Search outside databases for aliases for DDR1 genePrevious GC identifers: GC06P030907 GC06P030619 GC06P030959 GC06P030631
Summaries for DDR1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for DDR1 : Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with theirmicroenvironment. These molecules are involved in the regulation of cell growth, differentiationand metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal andtransformed epithelial cells and is activated by various types of collagen. This protein belongsto a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideumprotein discoidin I in their extracellular domain. Its autophosphorylation is achieved by allcollagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showedthat expression of this encoded protein is restricted to epithelial cells, particularly in thekidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantlyover-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. Thisgene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternativesplicing of this gene results in multiple transcript variants. [provided by RefSeq] UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 Function : May be involved in cell-cell interactions and recognition
Gene Wiki entry for DDR1
Genomic Location for DDR1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DDR1 gene Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33 DDR1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P030960:
(about GC identifiers )
Start:
30,956,784 bp from pter
End:
30,975,912 bp from pter
Size:
19,129 bases
Orientation:
plus strand
2 alternative locations : Chr 6+,c6_COX 30,989,009-31,005,083 Chr 6+,c6_QBL 30,984,304-31,000,378
RefSeq DNA sequence: NC_000006.10 NT_007592.14 NT_113891.1 NT_113893.1 Proteins for DDR1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 (See
protein sequence )Recommended Name: Epithelial discoidin domain-containing receptor 1 precursor Size : 913 amino acids; 101128 Da
Subcellular location : Isoform 1: Membrane; Single-pass type I membrane protein
Subcellular location : Isoform 2: Membrane; Single-pass type I membrane protein
Subcellular location : Isoform 3: Secreted (Potential)
Subcellular location : Isoform 4: Secreted (Potential)
Secondary accessions : B5A975 B5A976 Q14196 Q16562 Q2L6H3 Q4LE50 Q5ST11 Q5ST12 Q6NSK4 Q9UD37Alternative splicing : 4 isoforms : Q08345-1 Q08345-2 Q08345-3 Q08345-4
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001945.3 NP_054699.2 NP_054700.2 ENSEMBL proteins: ENSP00000365753 ENSP00000365752 ENSP00000318217 ENSP00000354844 ENSP00000365751 ENSP00000379631 ENSP00000365759 ENSP00000365754 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for DDR1: Assays for DDR1:
Protein
Domains/ Families for DDR1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q08345 ProtoNet protein and cluster: Q08345
3 Blocks protein families : IPB000421 Coagulation factor 5/8 type C domain (FA58C) IPB002011 Receptor tyrosine kinase IPB008266 Tyrosine protein kinase UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 Domain : The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligandor substrates Similarity : Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptorsubfamily Similarity : Contains 1 F5/8 type C domainSimilarity : Contains 1 protein kinase domain
Gene Function for DDR1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001954 Applied Biosystems Silencer ® siRNAs for DDR1 Sigma-Aldrich siRNA and siRNA Panels for DDR1 Sigma-Aldrich shRNA Panels and shRNA for DDR1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001954                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001954                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001954  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_013994 UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 Function : May be involved in cell-cell interactions and recognitionCatalytic activity : ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme Number (IUBMB): EC 2.7.10.1
Genatlas biochemistry entry for DDR1 :discoidin domains receptor family,member 1
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ddr1) :5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
):
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Pathways & Interactions for DDR1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for DDR1 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for DDR1 5/12 Interacting proteins for DDR1 (ENSP00000318217 3 Q08345 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 12
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006468 protein amino acid phosphorylation
IEA -- GO:0007155 cell adhesion
TAS 8302582 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
IEA --
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Drugs & Compounds for DDR1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for DDR1 8 Novoseek chemical compound relationships for DDR1 gene
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Transcripts for DDR1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001954 Sigma-Aldrich siRNA and siRNA Panels for DDR1 Sigma-Aldrich shRNA Panels and shRNA for DDR1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001954 NM_013993 NM_013994
REFSEQ mRNAs for DDR1 gene (3 alternative transcripts): NM_001954.4 NM_013993.2 NM_013994.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001954 NM_013993 NM_013994
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001954                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001954                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001954  
Additional cDNA sequence: AB210021.1 AF353182.1 AF353183.1 AK130776.1 AK291621.1 AK294793.1 AK295643.1 BC008716.2 BC013400.2 BC070070.1 CR605641.1 EU826613.1 EU826614.1 L11315.1 L20817.1 L57508.1 X74979.1 Z29093.1
24/42 DOTS entries (see all 42
): DT.100705281 DT.100815634 DT.99935384 DT.95158982 DT.75123383 DT.121354427 DT.102832990 DT.121354374 DT.100815626 DT.100815625 DT.92447581 DT.92050162 DT.95291688 DT.100815632 DT.121354367 DT.102832991 DT.121354412 DT.121354430 DT.95303275 DT.100815633 DT.121354388 DT.121354409 DT.100815629 DT.121354402
24/392 AceView cDNA sequences (see all 392
):BM262997 BQ919243 BQ671817 AI821641 AI382495 CB305834 BQ953137 AA487526 AF353183 AW860441 AI880304 AI457229 CA448451 AI251921 AK130776 AI275058 BG059813 AI813770 AA425346 AW591308 CR605641 BE018074 AA364485 BQ777533
highest scoring ESTs for DDR1 :L20817 AA329834 AA338319 AA341471 AA364485 AA385987 AA401005 AA425346 AA430320 AA464551
Unigene Cluster for DDR1: Discoidin domain receptor tyrosine kinase 1 Hs.631988 [show with all ESTs ] Unigene Representative Sequence: NM_013993 GeneLoc Exon Structure 8 Ensembl transcripts including schematic representations : ENST00000376569
ENST00000376568
ENST00000324771
ENST00000361741
ENST00000376567
ENST00000396342
ENST00000376575
ENST00000376570
Expression for DDR1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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DDR1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DDR1 1 / 2 / 3
10 probe-sets matching DDR1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCCCATTGGASOURCE GeneReport for Unigene cluster: Hs.631988 Expression variation in blood from EXPOLDB for DDR1
UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 Tissue specificity : Expressed at low levels in most adult tissues and is highest in the brain andlung. Abundant in breast carcinoma cell lines
Orthologs for DDR1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for DDR1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for DDR1 ENSEMBL Gene Tree for DDR1 Paralogs for DDR1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for DDR1 gene ROS1 2 DDR2 2
SNPs/Variants for DDR1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for DDR1 (up to first 250kb)
Disorders & Mutations for DDR1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600408 10/18 Novoseek disease relationships for DDR1 gene (see all 18
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
fibrosis idiopathic pulmonary
46.59
5
16690978 (1), 16507902 (1), 15879152 (1), 16424224 (1)
pediatric brain tumor
44.18
4
9075249 (2), 11126911 (1)
keloid
34.98
3
17554880 (2), 11129182 (1)
bronchoalveolar lavage fluid
33.46
4
15879152 (2), 18941260 (1), 16166739 (1)
pulmonary fibrosis
29.79
4
16690978 (2), 18065762 (1), 16424224 (1)
tumors
23.19
21
11126911 (5), 11606478 (2), 14500648 (1), 16440311 (1) (see all 10 )
glioblastoma multiforme
22.13
1
16234985 (1)
breast cancer
14.71
5
15701836 (1), 17690741 (1), 16912190 (1), 11493640 (1) (see all 5 )
cancer
13.44
7
17970783 (1), 17690741 (1), 7845687 (1), 16912190 (1) (see all 7 )
colon carcinoma
12.23
1
7845687 (1)
About this table 1 PharmGKB disease relationship for DDR1 gene About this table Human Gene Mutation Database : DDR1 Genetic Association Database: DDR1 Human Genome Epidemiology Navigator: DDR1 (3 documents)
Medical News for DDR1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for DDR1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/132 PubMed articles for DDR1 gene (see all 132
): Linkage and association studies of discoidin domain receptor 1 (DDR1) single nucleotide polymorphisms (SNPs) in juvenile oligoarthritis. (PubMed id 15213330) 1, 3, 6 Zeggini E....Donn R. (2004) The genomic structure of discoidin receptor tyrosine kinase. (PubMed id 8796349) 1, 3, 4 Playford M.P....Ganesan T.S. (1996) Receptor protein tyrosine kinase DDR is up-regulated by p53 protein. (PubMed id 8977099) 1, 3, 4 Sakuma S.... Abe H. (1996) Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain. (PubMed id 8302582) 1, 3, 4 Perez J.L.... Wong T.W. (1994) Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis. (PubMed id 18593464) 3, 4 Jin P.... Paleolog E.M. (2008) Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PubMed id 16702430) 3, 4 Shiina T.... Bahram S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 3, 4 Mungall A.J.... Beck S. (2003) Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines. (PubMed id 8622863) 3, 4 Perez J.L.... Wong T.W. (1996) Localization of an epithelial-specific receptor kinase (EDDR1) to chromosome 6q16. (PubMed id 7789998) 2, 3 Shelling A.N....Ganesan T.S. (1995)
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Genome Databases showing DDR1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing DDR1
(According to HUGE )
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Specialized Databases showing DDR1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for DDR1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009