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DDR1 Gene

protein-coding   GIFtS: 65

GC06P030960
discoidin domain receptor tyrosine kinase 1
(Previous names: discoidin domain receptor family, member 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: NTRK4, PTK3A, NEP, CAK, EDDR1)
Services    

Aliases &
Descriptions
for DDR1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CAK 2, 3
CD167 1, 2
DDR 2
EC 2.7.10.1 3
EDDR1 2, 3
HGK2 3
MCK10 2
NEP 2, 3
NTRK4 2, 3
OTTHUMP00000029343 2
OTTHUMP00000029344 2
OTTHUMP00000029345 2
OTTHUMP00000029346 2
OTTHUMP00000029347 2
PTK3 2
PTK3A 2, 3
RTK6 1, 2, 3
TRKE 2, 3
Descriptions
CD167 antigen-like family member A 3
CD167a antigen 3
Cell adhesion kinase 2, 3
Discoidin receptor tyrosine kinase 2, 3
Epithelial discoidin domain receptor 1 2, 3
PTK3A protein tyrosine kinase 3A 2
Protein-tyrosine kinase RTK 6 3
TRK E 3
Tyrosine kinase DDR 3
Tyrosine-protein kinase CAK 3
discoidin domain receptor family, member 1 1, 2
discoidin domain receptor tyrosine kinase 1 2
mammarian carcinoma kinase 10 2
neuroepithelial tyrosine kinase 2
neurotrophic tyrosine kinase, receptor, type 4 2
External Ids
HGNC: 27301
Entrez Gene: 7802
UniProtKB: Q083453
Ensembl: ENSG000002045807
Search outside databases for aliases for DDR1 gene

Previous GC identifers: GC06P030907 GC06P030619 GC06P030959 GC06P030631

Summaries
for DDR1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for DDR1:
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their
microenvironment. These molecules are involved in the regulation of cell growth, differentiation
and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and
transformed epithelial cells and is activated by various types of collagen. This protein belongs
to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum
protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all
collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed
that expression of this encoded protein is restricted to epithelial cells, particularly in the
kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly
over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This
gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative
splicing of this gene results in multiple transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
Function: May be involved in cell-cell interactions and recognition

Gene Wiki entry for DDR1

Genomic Location
for DDR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the DDR1 gene  

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

DDR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030960:     (about GC identifiers)

Start:
 30,956,784 bp from pter
End:
 30,975,912 bp from pter
Size:
 19,129 bases
Orientation:
 plus strand

2 alternative locations:
Chr6+,c6_COX 30,989,009-31,005,083      Chr6+,c6_QBL 30,984,304-31,000,378     
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  NT_113891.1  NT_113893.1  

Proteins
for DDR1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345 (See protein sequence)
Recommended Name: Epithelial discoidin domain-containing receptor 1 precursor  
Size: 913 amino acids; 101128 Da
Subcellular location: Isoform 1: Membrane; Single-pass type I membrane protein
Subcellular location: Isoform 2: Membrane; Single-pass type I membrane protein
Subcellular location: Isoform 3: Secreted (Potential)
Subcellular location: Isoform 4: Secreted (Potential)
Secondary accessions: B5A975 B5A976 Q14196 Q16562 Q2L6H3 Q4LE50 Q5ST11 Q5ST12 Q6NSK4 Q9UD37
Alternative splicing: 4 isoforms:  Q08345-1   Q08345-2   Q08345-3   Q08345-4   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_001945.3  NP_054699.2  NP_054700.2  


    ENSEMBL proteins: 
    ENSP00000365753 ENSP00000365752 ENSP00000318217 ENSP00000354844 ENSP00000365751 ENSP00000379631 
    ENSP00000365759 ENSP00000365754 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    R&D Systems Recombinant & Natural Proteins for DDR1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (MCK10)
    Human Recombinant Proteins from Abnova (DDR1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887 integral to plasma membrane TAS8390675
    GO:0016020 membrane IEA--
    About this table

    Antibodies for DDR1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for DDR1
    R&D Systems Antibodies for DDR1
    Antibodies from Abcam (MCK10), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (DDR1)
    Novus Biologicals Antibodies for DDR1

    Assays for DDR1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for DDR1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR017441 Protein_kinase_ATP_BS
     IPR001245 Tyr_pkinase
     IPR000421 Coagulation_factor_5/8-type_C
     IPR002011 Recept_tyr_kinase-II_CS
     IPR000719 Prot_kinase_core


       GeneDecks  DDR1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q08345

    ProtoNet protein and cluster: Q08345

    3 Blocks protein families:
    IPB000421 Coagulation factor 5/8 type C domain (FA58C)
    IPB002011 Receptor tyrosine kinase
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
    Domain: The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand
    or substrates
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor
    subfamily
    Similarity: Contains 1 F5/8 type C domain
    Similarity: Contains 1 protein kinase domain

    Gene Function
    for DDR1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (DDR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (DDR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001954

                  Applied Biosystems Silencer® siRNAs for DDR1

                  Sigma-Aldrich siRNA and siRNA Panels for DDR1  
                         Sigma-Aldrich shRNA Panels and shRNA for DDR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for DDR1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001954
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001954
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001954 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_013994

    UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
    Function: May be involved in cell-cell interactions and recognition
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme Number (IUBMB): EC 2.7.10.1 

    Genatlas biochemistry entry for DDR1:
    discoidin domains receptor family,member 1

    7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ddr1):

    craniofacialembryogenesisendocrine/exocrine glandgrowth/sizehearing/vestibular/ear
    reproductive systemskeleton

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS9659899
    GO:0004872 receptor activity IEA--
    GO:0005515 protein binding IPI17721511
    GO:0005524 ATP binding IEA--
    About this table

    Pathways & Interactions
    for DDR1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  DDR1  (Your Favorite Gene powered by Ingenuity) 
     Dendritic Cell Maturation

       GeneDecks  DDR1 for the pathways selected above  
    About GeneDecksing

    2 Cell Signaling Technology (CST) Pathways for DDR1: 
     Translational Control: Regulation of eIF4E and p70 S6 Kinase
     Protein Acetylation

       GeneDecks  DDR1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  DDR1 


    5/12 Interacting proteins for DDR1 (ENSP000003182173 Q083451, 2) via UniProtKB, MINT, and/or STRING (see all 12 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRS1P355681EBI-711903, EBI-517592
    RGS2P412202MINT-63731
    SNAPINO952952MINT-64069
    SNRNP40Q96DI72MINT-64071
    TM4SF1P304082MINT-63643
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein amino acid phosphorylation IEA--
    GO:0007155 cell adhesion TAS8302582
    GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    About this table

    Drugs & Compounds
    for DDR1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for DDR1
    8 Novoseek chemical compound relationships for DDR1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 71.35 89 16440311 (4), 18938156 (3), 16611743 (3), 12628922 (2) (see all 46)
    matrigel 30.17 3 17970783 (1), 17001518 (1)
    ribonucleic acid 29.94 5 11126911 (1), 17001518 (1)
    wortmannin 16.21 1 10872813 (1)
    cgmp 1.47 2 12571245 (1), 8663415 (1)
    atp 0.00 6 8385768 (1)
    calcium 0.00 8 8385768 (1), 17064702 (1)
    phosphatidylinositol 0.00 3 12471617 (1), 10872813 (1)
    About this table


    Transcripts
    for DDR1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (DDR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (DDR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001954

                  Sigma-Aldrich siRNA and siRNA Panels for DDR1  
                         Sigma-Aldrich shRNA Panels and shRNA for DDR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001954  NM_013993  NM_013994  

    REFSEQ mRNAs for DDR1 gene (3 alternative transcripts): 

    NM_001954.4   NM_013993.2   NM_013994.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001954  NM_013993  NM_013994  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001954
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001954
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001954 

    Additional cDNA sequence: 

    AB210021.1 AF353182.1 AF353183.1 AK130776.1 AK291621.1 AK294793.1 AK295643.1 BC008716.2 
    BC013400.2 BC070070.1 CR605641.1 EU826613.1 EU826614.1 L11315.1 L20817.1 L57508.1 
    X74979.1 Z29093.1 

    24/42 DOTS entries (see all 42 ):

    DT.100705281  DT.100815634  DT.99935384  DT.95158982  DT.75123383  DT.121354427  DT.102832990  DT.121354374 
    DT.100815626  DT.100815625  DT.92447581  DT.92050162  DT.95291688  DT.100815632  DT.121354367  DT.102832991 
    DT.121354412  DT.121354430  DT.95303275  DT.100815633  DT.121354388  DT.121354409  DT.100815629  DT.121354402 

    24/392 AceView cDNA sequences (see all 392 ):

    BM262997 BQ919243 BQ671817 AI821641 AI382495 CB305834 BQ953137 AA487526 
    AF353183 AW860441 AI880304 AI457229 CA448451 AI251921 AK130776 AI275058 
    BG059813 AI813770 AA425346 AW591308 CR605641 BE018074 AA364485 BQ777533 

    highest scoring ESTs for DDR1:

    L20817 AA329834 AA338319 AA341471 AA364485 AA385987 AA401005 AA425346 AA430320 AA464551 

    Unigene Cluster for DDR1:

    Discoidin domain receptor tyrosine kinase 1
    Hs.631988  [show with all ESTs]
    Unigene Representative Sequence: NM_013993


    GeneLoc Exon Structure

    8 Ensembl transcripts including schematic representations:
    ENST00000376569  ENST00000376568  ENST00000324771  ENST00000361741  ENST00000376567  ENST00000396342  
    ENST00000376575  ENST00000376570  

    Expression
    for DDR1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    DDR1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for DDR1

    1 / 2 / 3

    10 probe-sets matching DDR1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		1007_s_at2, 3 U133-A 3 1.00 0.33 0.99 1.04 U48705 0.20 1.00 0.72 1
    36643_at2, 3 U95-A 3 0.94 0.33 1.00 0.97 L20817 1.00 1.00 1.00 1

    		208779_x_at2, 3 U133-A 3 1.00 0.46 -- -- L20817 1.00 1.00 1.00 1

    		207169_x_at2, 3 U133-A 3 1.00 0.33 -- -- NM_001954 0.60 1.00 0.82 1

    		210749_x_at2, 3 U133-A 3 1.00 0.33 -- -- L11315 0.80 1.00 0.91 1

    		1007_s_at2, 3 U133-A 3 1.00 0.33 -- -- U48705 0.20 1.00 0.72 1

    		208779_x_at2 U133Plus2 3 1.00 0.46 -- -- -- -- -- -- --

    		207169_x_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --

    		210749_x_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --

    		1007_s_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --
    GeneDecks  DDR1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCCATTGGA

    SOURCE GeneReport for Unigene cluster: Hs.631988

    Expression variation in blood from EXPOLDB for DDR1

    UniProtKB/Swiss-Prot: DDR1_HUMAN, Q08345
    Tissue specificity: Expressed at low levels in most adult tissues and is highest in the brain and
    lung. Abundant in breast carcinoma cell lines

    Orthologs
    for DDR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for DDR1 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 DDR11   -- discoidin domain receptor tyrosine kinase 1 91.16(n)
    95.84(a)    		 474832  XM_532062.2  XP_532062.2 
    chimpanzee
    (Pan troglodytes)    		 DDR11   -- discoidin domain receptor tyrosine kinase 1 99.66(n)
    100(a)    		 462548  XM_001150248.1  XP_001150248.1 
    cow
    (Bos taurus)    		 DDR11   -- discoidin domain receptor tyrosine kinase 1 91.25(n)
    95.38(a)    		 534092  NM_001076012.1  NP_001069480.1 
    rat
    (Rattus norvegicus)    		 Ddr11   -- discoidin domain receptor tyrosine kinase 1 87.13(n)
    94.06(a)    		 25678  NM_013137.1  NP_037269.1 
    mouse
    (Mus musculus)    		 Ddr11, 5 17 (21.50 cM)5
    		 discoidin domain receptor family, member 11, 5 87.75(n)1
    93.95(a)1    		 123051  NM_007584.21  NP_031610.11 
     AF0262595  AI3236815  (see all 18)
    About this table        Species with no ortholog for DDR1

    ENSEMBL Gene Tree for DDR1

    Paralogs
    for DDR1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for DDR1 gene
    ROS12  DDR22  

    SNPs/Variants
    for DDR1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/176 NCBI SNPs in DDR1 are shown (see all 176 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 109)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs12643281,2
    		A,C,F,H30958121(-) GTCCCC/TGAGAA 1 -- ng517Minor allele frequency- T:0.47EU EA WA NA 542
    rs10496281,2
    		A,C,F,H30975085(+) GGGAGC/TGATCC 3 -- ut319Minor allele frequency- T:0.49MN EA NA EU WA 2324
    rs12643271,2
    		A,C,F,H30958561(-) CAGCCC/TGTCAT 2 -- ng519Minor allele frequency- T:0.25NA MN EA EU WA 1802
    rs84081,2
    		A,C,F,H30975645(+) CCCACT/CTGCAG 3 -- ut31 ese311Minor allele frequency- C:0.29MN NA EU EA WA 1294
    rs10496331,2
    		A,C,F,H30975506(-) TTGTCC/TTCCTC 3 -- ut31 ese35Minor allele frequency- T:0.07EU EA WA MN 600
    rs95010321,2
    		A,C,F,H30958170(+) TGGAAT/CGGGCT 1 -- ng514Minor allele frequency- C:0.39EU EA WA 402
    rs94688431,2
    		A,C,F,H30975937(+) GGGAAT/CTTGGT 3 -- ng318Minor allele frequency- C:0.24EU EA WA 816
    rs12643231,2
    		A,C,F,H30963886(-) ttcacT/Cagcct 3 -- int1 ng519Minor allele frequency- C:0.45EU EA WA NS 1012
    rs94688441,2
    		A,C,F,H30976212(+) taaacG/Cccttt 3 -- ng314Minor allele frequency- C:0.38EU EA WA 414
    rs94616381,2
    		A,C,F,H30959284(+) TTTCAG/CTGTGC 2 -- ng514Minor allele frequency- C:0.39EU EA WA 416
    About this table

    HapMap Linkage Disequilibrium images for DDR1 (up to first 250kb)

    Disorders & Mutations
    for DDR1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 600408

    10/18 Novoseek disease relationships for DDR1 gene (see all 18 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrosis idiopathic pulmonary 46.59 5 16690978 (1), 16507902 (1), 15879152 (1), 16424224 (1)
    pediatric brain tumor 44.18 4 9075249 (2), 11126911 (1)
    keloid 34.98 3 17554880 (2), 11129182 (1)
    bronchoalveolar lavage fluid 33.46 4 15879152 (2), 18941260 (1), 16166739 (1)
    pulmonary fibrosis 29.79 4 16690978 (2), 18065762 (1), 16424224 (1)
    tumors 23.19 21 11126911 (5), 11606478 (2), 14500648 (1), 16440311 (1) (see all 10)
    glioblastoma multiforme 22.13 1 16234985 (1)
    breast cancer 14.71 5 15701836 (1), 17690741 (1), 16912190 (1), 11493640 (1) (see all 5)
    cancer 13.44 7 17970783 (1), 17690741 (1), 7845687 (1), 16912190 (1) (see all 7)
    colon carcinoma 12.23 1 7845687 (1)
    About this table

    1 PharmGKB disease relationship for DDR1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    Human Gene Mutation Database: DDR1
    Genetic Association Database: DDR1
    Human Genome Epidemiology Navigator: DDR1 (3 documents)

    Medical News
    for DDR1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for DDR1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/132 PubMed articles for DDR1 gene (see all 132 ):

    Search for DDR1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
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    Genome Databases showing DDR1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 780 HGNC: 2730 AceView: DDR1 Ensembl:ENSG00000204580 euGenes: HUgn780
    ECgene: DDR1 H-InvDB: DDR1

    Other Databases showing DDR1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing DDR1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for DDR1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for DDR1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for DDR1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for DDR1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for DDR1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for DDR1 Antibodies for DDR1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for DDR1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (DDR1)
     Antibodies (DDR1)
     Chimera RNAi (DDR1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (MCK10)
     Antibodies (MCK10)
     Search OriGene for DDR1
     Search Tocris compounds for DDR1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for DDR1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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