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DDO Gene

protein-coding   GIFtS: 59
GCID: GC06M110672

D-Aspartate Oxidase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
D-Aspartate Oxidase1 2     DDO-22
DASOX2 3 5     Aspartic Oxidase2
EC 1.4.3.13 8     D-Aspartate Oxidase, DDO2
DDO-12     

External Ids:    HGNC: 27271   Entrez Gene: 85282   Ensembl: ENSG000002037977   OMIM: 1244505   UniProtKB: Q994893   

Export aliases for DDO gene to outside databases

Previous GC identifers: GC06M110539 GC06M110736 GC06M110758 GC06M110820 GC06M108280


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDO Gene:
The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of
D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can
serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDO Gene:
DDO (D-aspartate oxidase) is a protein-coding gene. GO annotations related to this gene include D-amino-acid oxidase activity and receptor binding. An important paralog of this gene is DAO.

UniProtKB/Swiss-Prot: OXDD_HUMAN, Q99489
Function: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl
D-aspartate

Gene Wiki entry for DDO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDO gene promoter:
         MEF-2   HNF-1A   AREB6   MEF-2A   HNF-1   Cart-1   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDO promoter sequence
   Search Chromatin IP Primers for DDO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q22.1

DDO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDO gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M110672:  view genomic region     (about GC identifiers)

Start:
110,712,974 bp from pter      End:
110,736,765 bp from pter
Size:
23,792 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: OXDD_HUMAN, Q99489 (See protein sequence)
Recommended Name: D-aspartate oxidase  
Size: 341 amino acids; 37535 Da
Cofactor: FAD or 6-hydroxyflavin adenine dinucleotide
Secondary accessions: A8KAG4 Q5JXM4 Q5JXM5 Q5JXM6 Q8N552
Alternative splicing: 4 isoforms:  Q99489-1   Q99489-2   Q99489-3   Q99489-4   (Ref.6 (DN990727) sequence is in conflict in position: 9:T->N)

Explore the universe of human proteins at neXtProt for DDO: NX_Q99489

Explore proteomics data for DDO at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for DDO (Q99489)
     VVHHYGHG  VTLGGTRQKGDWN 


    See DDO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003640.2  NP_004023.2  

    ENSEMBL proteins: 
     ENSP00000357920   ENSP00000357919   ENSP00000436642  

    DDO Human Recombinant Protein Products:

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    GenScript Custom Purified and Recombinant Proteins Services for DDO
    Novus Biologicals DDO Proteins
    Novus Biologicals DDO Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDO

     
    Search eBioscience for Proteins for DDO 

     
    antibodies-online proteins for DDO (14 products) 

     
    antibodies-online peptides for DDO

    DDO Antibody Products:

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    Abcam antibodies for DDO
    Cloud-Clone Corp. Antibodies for DDO
    ThermoFisher Antibody for DDO
    antibodies-online antibodies for DDO (35 products) 

    DDO Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDO
    Cloud-Clone Corp. CLIAs for DDO
    Search eBioscience for ELISAs for DDO 
    antibodies-online kits for DDO (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006076 FAD-dep_OxRdtase
     IPR006181 D-amino_acid_oxidase_CS
     IPR023209 D-aa_oxidase

    Graphical View of Domain Structure for InterPro Entry Q99489

    ProtoNet protein and cluster: Q99489

    1 Blocks protein domain: IPB006181 D-amino acid oxidase

    UniProtKB/Swiss-Prot: OXDD_HUMAN, Q99489
    Similarity: Belongs to the DAMOX/DASOX family


    Find genes that share domains with DDO           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OXDD_HUMAN, Q99489
    Function: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl
    D-aspartate
    Catalytic activity: D-aspartate + H(2)O + O(2) = oxaloacetate + NH(3) + H(2)O(2)

         Enzyme Number (IUBMB): EC 1.4.3.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0005515protein binding IPI9820813
    GO:0008445D-aspartate oxidase activity IDA--
    GO:0016491oxidoreductase activity ----
    GO:0016641oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor ----
         
    Find genes that share ontologies with DDO           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ddo):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  nervous system 
     reproductive system 

    Find genes that share phenotypes with DDO           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DDO: Ddotm1Rdl Ddotm1Snyd

       genOway: Develop your customized and physiologically relevant rodent model for DDO

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate DDO:
    hsa-miR-587 hsa-miR-590-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDDO 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDO
    Predesigned siRNA for gene silencing in human, mouse, rat DDO

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DDO

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    GenScript: all cDNA clones in your preferred vector: DDO (NM_005216)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDO

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    Browse ESI BIO Cell Lines and PureStem Progenitors for DDO 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OXDD_HUMAN, Q99489: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome NAS9820813

    Find genes that share ontologies with DDO           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDO About    
    See pathways by source

    SuperPathContained pathways About
    1Peroxisome
    Peroxisome
    2Alanine, aspartate and glutamate metabolism
    Alanine, aspartate and glutamate metabolism


    Find genes that share SuperPaths with DDO           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for DDO):
        Alanine, aspartate and glutamate metabolism
    Peroxisome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDO
    Interactions:

        Search GeneGlobe Interaction Network for DDO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for DDO (Q994893 ENSP000003579204) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PEX5P505423, ENSP000004074014I2D: score=1 STRING: ENSP00000407401
    IL4I1ENSP000003425574STRING: ENSP00000342557
    GOT1ENSP000003595394STRING: ENSP00000359539
    GOT2ENSP000002452064STRING: ENSP00000245206
    NIT2ENSP000003776964STRING: ENSP00000377696
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006531aspartate metabolic process IEA--
    GO:0006533aspartate catabolic process IDA9163533
    GO:0007320insemination IEA--
    GO:0007625grooming behavior IEA--
    GO:0019478D-amino acid catabolic process IDA--

    Find genes that share ontologies with DDO           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDO (OXDD)

    7 HMDB Compounds for DDO    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    D-Aspartic acid(-)-Aspartic acid (see all 19)1783-96-6--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    Oxalacetic acid2-Ketosuccinate (see all 20)328-42-7--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    3 Novoseek inferred chemical compound relationships for DDO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pipecolic acid 79.5 1 8556358 (1)
    aspartate 74.3 34 9820813 (3), 11713869 (3), 12209855 (3), 9163533 (2) (see all 14)
    nmda 21.1 1 9163533 (1)



    Find genes that share compounds with DDO           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDO gene (2 alternative transcripts): 
    NM_003649.2  NM_004032.2  

    Unigene Cluster for DDO:

    D-aspartate oxidase
    Hs.591348  [show with all ESTs]
    Unigene Representative Sequence: NM_003649
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368924(uc003puc.3) ENST00000368923(uc003pud.3) ENST00000479373

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDO using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DDO:
    hsa-miR-587 hsa-miR-590-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDDO 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDO
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDO (NM_005216)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDO
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDO
    OriGene qSTAR qPCR primer pairs in human, mouse for DDO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDO
      QuantiTect SYBR Green Assays in human, mouse, rat DDO
      QuantiFast Probe-based Assays in human, mouse, rat DDO

    Additional mRNA sequence: 

    AB496420.1 AK293029.1 BC032786.1 D89858.1 

    3 DOTS entries:

    DT.310390  DT.100746843  DT.121322695 

    Selected AceView cDNA sequences (see all 46):

    BM544810 BM807293 AL553190 BX489908 AI733581 D89858 NM_004032 AA555279 
    BF436252 NM_003649 AX786391 CR590300 CD251036 AI470186 CD677087 BX500405 
    BI824425 BI819188 BE502807 BE277493 T26465 AK127146 BE788738 AA994974 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGCTTACT
    DDO Expression
    About this image


    DDO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Gonad
             Primordial germ cell-like cells
     
     Neural Tube (Nervous System)
             Metencephalon
    DDO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591348
        Custom PCR Arrays for DDO
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DDO gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddo1 , 5 D-aspartate oxidase1, 5 80.65(n)1
    80.35(a)1
      10 (22.00 cM)5
    705031  NM_027442.51  NP_081718.21 
     406300115 
    chicken
    (Gallus gallus)
    Aves DDO1 D-aspartate oxidase 66.76(n)
    64.22(a)
      770953  XM_004940306.1  XP_004940363.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDO6
    D-aspartate oxidase
    65(a)
    1 ↔ 1
    1(191741401-191753554)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ddo1 D-aspartate oxidase 60.93(n)
    59.94(a)
      100488513  XM_004914560.1  XP_004914617.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003327331 D-aspartate oxidase-like 58.87(n)
    54.41(a)
      100332733  XM_002665140.2  XP_002665186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112363
    CG123381
    D-aspartate oxidase3
    CG123381
    35(a)3
    48.19(n)1
    38.39(a)1
      27B13
    361281  NM_136759.21  NP_610603.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y69A2AR.53
    daao-11
    daao-11 37(a)3
    45.64(n)1
    39.43(a)1
      IV(2614205-2617036)3
    35657751  NM_067833.51  NP_500234.31 
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0A02475g1 KLLA0A02475g 42.25(n)
    32.17(a)
      2896688  XM_451109.1  XP_451109.1 


    ENSEMBL Gene Tree for DDO (if available)
    TreeFam Gene Tree for DDO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDO gene
    DAO2  
    3 SIMAP similar genes for DDO using alignment to 2 protein entries:     OXDD_HUMAN (see all proteins):
    ddo    DAO    DKFZp686F04272

    Find genes that share paralogs with DDO           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDO (see all 656)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362444
    A breast cancer sample4--see VAR_0362442 F L mis40--------
    rs1460128511,2
    C--110712898(+) TTTCCA/GTCCAC 2 -- ds50010--------
    rs93741701,2
    C,F,A,H--110712991(+) ATTTAA/GCTCAA 2 -- ds500115Minor allele frequency- G:0.48NS EA NA CSA WA 787
    rs10553011,2
    C,F,A,H--110713042(-) AAGTAT/CTGGGG 2 -- ds500116Minor allele frequency- C:0.45MN NS EA NA CSA WA 965
    rs412885881,2
    C,F--110713060(+) AACTGA/C/TGGAGT 2 -- ds50011NA 2
    rs1493330911,2
    --110713103(+) CCACCC/TTAATT 2 -- ds50010--------
    rs765291521,2
    C,F--110713231(+) TGTTTG/AACCCC 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1446660611,2
    --110713382(+) GCACTA/GTGTGA 2 -- ds50010--------
    rs1931306161,2
    --110713413(+) GAGGAA/CTTATG 2 -- ut310--------
    rs1133891331,2
    C,F--110713460(+) AGCTCA/TGCAAT 2 -- ut312Minor allele frequency- T:0.33CSA 3

    HapMap Linkage Disequilibrium report for DDO (110712974 - 110736765 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DDO:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732570CNV Deletion23290073
    nsv516397CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 124450    OMIM disorders: --


    Find genes that share disorders with DDO           About GenesLikeMe

    Genetic Association Database (GAD): DDO
    Human Genome Epidemiology (HuGE) Navigator: DDO (2 documents)

    Export disorders for DDO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDO gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with DDO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional characterization of the human brain D- aspartate oxidase. (PubMed id 9163533)1, 2, 3, 9 Setoyama C. and Miura R. (J. Biochem. 1997)
    2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain. (PubMed id 12209855)1, 9 Zaar K....Fahimi H.D. (J. Comp. Neurol. 2002)
    6. C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal. (PubMed id 9820813)1, 9 Amery L....Van Veldhoven P.P. (Biochem. J. 1998)
    7. D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man. (PubMed id 1991137)1, 9 Van Veldhoven P.P....Mannaerts G.P. (Biochim. Biophys. Acta 1991)
    8. No association between the D-aspartate oxidase locus and schizophrenia. (PubMed id 19125110)1, 9 Jamra R.A....Schumacher J. (Psychiatr. Genet. 2009)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8528 HGNC: 2727 AceView: DDO Ensembl:ENSG00000203797 euGenes: HUgn8528
    ECgene: DDO Kegg: 8528 H-InvDB: DDO

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDO gene:
    Search GeneIP for patents involving DDO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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