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Aliases for DDO Gene

Aliases for DDO Gene

  • D-Aspartate Oxidase 2 3
  • EC 1.4.3.1 4 63
  • DASOX 3 4
  • D-Aspartate Oxidase, DDO 3
  • Aspartic Oxidase 3
  • DDO-1 3
  • DDO-2 3

External Ids for DDO Gene

Previous GeneCards Identifiers for DDO Gene

  • GC06M110539
  • GC06M110736
  • GC06M110758
  • GC06M110672
  • GC06M110820
  • GC06M108280

Summaries for DDO Gene

Entrez Gene Summary for DDO Gene

  • The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDO Gene

DDO (D-Aspartate Oxidase) is a Protein Coding gene. Among its related pathways are Peroxisome and Alanine, aspartate and glutamate metabolism. GO annotations related to this gene include receptor binding and cofactor binding. An important paralog of this gene is DAO.

UniProtKB/Swiss-Prot for DDO Gene

  • Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate

Gene Wiki entry for DDO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDO Gene

Genomics for DDO Gene

Regulatory Elements for DDO Gene

Genomic Location for DDO Gene

Chromosome:
6
Start:
110,391,771 bp from pter
End:
110,415,562 bp from pter
Size:
23,792 bases
Orientation:
Minus strand

Genomic View for DDO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDO Gene

Proteins for DDO Gene

  • Protein details for DDO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99489-OXDD_HUMAN
    Recommended name:
    D-aspartate oxidase
    Protein Accession:
    Q99489
    Secondary Accessions:
    • A8KAG4
    • Q5JXM4
    • Q5JXM5
    • Q5JXM6
    • Q8N552

    Protein attributes for DDO Gene

    Size:
    341 amino acids
    Molecular mass:
    37535 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692; Name=6-hydroxy-FAD; Xref=ChEBI:CHEBI:60470;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDO Gene

Proteomics data for DDO Gene at MOPED

Selected DME Specific Peptides for DDO Gene

Post-translational modifications for DDO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDO Gene

Antibody Products

Domains & Families for DDO Gene

Protein Domains for DDO Gene

Suggested Antigen Peptide Sequences for DDO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99489

UniProtKB/Swiss-Prot:

OXDD_HUMAN :
  • Belongs to the DAMOX/DASOX family.
Family:
  • Belongs to the DAMOX/DASOX family.
genes like me logo Genes that share domains with DDO: view

No data available for Gene Families for DDO Gene

Function for DDO Gene

Molecular function for DDO Gene

UniProtKB/Swiss-Prot CatalyticActivity:
D-aspartate + H(2)O + O(2) = oxaloacetate + NH(3) + H(2)O(2)
UniProtKB/Swiss-Prot Function:
Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate

Enzyme Numbers (IUBMB) for DDO Gene

Gene Ontology (GO) - Molecular Function for DDO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003884 D-amino-acid oxidase activity --
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 9820813
GO:0008445 D-aspartate oxidase activity IDA 9163533
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with DDO: view
genes like me logo Genes that share phenotypes with DDO: view

Animal Models for DDO Gene

MGI Knock Outs for DDO:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDO

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DDO Gene

Localization for DDO Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDO Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDO Gene COMPARTMENTS Subcellular localization image for DDO gene
Compartment Confidence
peroxisome 5
cytosol 3

Gene Ontology (GO) - Cellular Components for DDO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005777 peroxisome NAS 9820813
genes like me logo Genes that share ontologies with DDO: view

Pathways & Interactions for DDO Gene

genes like me logo Genes that share pathways with DDO: view

Pathways by source for DDO Gene

Gene Ontology (GO) - Biological Process for DDO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006531 aspartate metabolic process IEA --
GO:0006533 aspartate catabolic process IDA 9163533
GO:0007320 insemination IEA --
GO:0007625 grooming behavior IEA --
GO:0019478 D-amino acid catabolic process IDA 20603179
genes like me logo Genes that share ontologies with DDO: view

No data available for SIGNOR curated interactions for DDO Gene

Drugs & Compounds for DDO Gene

(4) Drugs for DDO Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
D-Aspartic acid Experimental Pharma 0
Hydrogen peroxide Pharma 42
NMDA Pharma Full agonist, Agonist 0

(6) Additional Compounds for DDO Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Oxalacetic acid
  • 2-Ketosuccinate
  • 2-Ketosuccinic acid
  • 2-Oxobutanedioate
  • 2-Oxobutanedioic acid
  • 2-Oxosuccinate
328-42-7
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
aspartate
genes like me logo Genes that share compounds with DDO: view

Transcripts for DDO Gene

mRNA/cDNA for DDO Gene

Unigene Clusters for DDO Gene

D-aspartate oxidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDO

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDO Gene

No ASD Table

Relevant External Links for DDO Gene

GeneLoc Exon Structure for
DDO
ECgene alternative splicing isoforms for
DDO

Expression for DDO Gene

mRNA expression in normal human tissues for DDO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDO Gene

This gene is overexpressed in Heart - Left Ventricle (x6.8).

Protein differential expression in normal tissues from HIPED for DDO Gene

This gene is overexpressed in Plasma (23.9), Heart (22.1), and Adrenal (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDO Gene



SOURCE GeneReport for Unigene cluster for DDO Gene Hs.591348

genes like me logo Genes that share expression patterns with DDO: view

Protein tissue co-expression partners for DDO Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DDO Gene

Orthologs for DDO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDO 35
  • 86.61 (n)
  • 84.46 (a)
DDO 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDO 35
  • 75.68 (n)
  • 74.92 (a)
DDO 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddo 35
  • 80.65 (n)
  • 80.35 (a)
Ddo 16
Ddo 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDO 35
  • 99.64 (n)
  • 99.46 (a)
DDO 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddo 35
  • 79.77 (n)
  • 81.82 (a)
oppossum
(Monodelphis domestica)
Mammalia DDO 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDO 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDO 35
  • 66.76 (n)
  • 64.22 (a)
DDO 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDO 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddo 35
  • 60.93 (n)
  • 59.94 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332733 35
  • 58.87 (n)
  • 54.41 (a)
DDO (1 of 2) 36
  • 53 (a)
OneToMany
DDO (2 of 2) 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11236 37
  • 35 (a)
CG12338 35
  • 48.19 (n)
  • 38.39 (a)
CG12338 36
  • 38 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005323 35
  • 45.82 (n)
  • 40.56 (a)
worm
(Caenorhabditis elegans)
Secernentea Y69A2AR.5 37
  • 37 (a)
daao-1 35
  • 45.64 (n)
  • 39.43 (a)
ddo-1 36
  • 32 (a)
ManyToMany
ddo-2 36
  • 29 (a)
ManyToMany
ddo-3 36
  • 27 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02475g 35
  • 42.25 (n)
  • 32.17 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06558 35
  • 43.48 (n)
  • 33.97 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC1450.07c 35
  • 43.55 (n)
  • 32.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
ManyToMany
Species with no ortholog for DDO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDO Gene

ENSEMBL:
Gene Tree for DDO (if available)
TreeFam:
Gene Tree for DDO (if available)

Paralogs for DDO Gene

Paralogs for DDO Gene

(3) SIMAP similar genes for DDO Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DDO: view

Variants for DDO Gene

Sequence variations from dbSNP and Humsavar for DDO Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs17621 - 110,393,113(-) CATCC(C/T)ATGTA reference, missense
rs17622 - 110,393,236(-) GCAGA(C/G)AGCTT reference, missense
rs17623 - 110,393,037(-) GATTC(G/T)TTCCC missense, reference
rs717600 -- 110,400,362(-) TGATG(A/G)GGCGC intron-variant
rs763563 -- 110,401,043(-) GGTGC(A/C)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDO Gene

Variant ID Type Subtype PubMed ID
esv2732570 CNV Deletion 23290073
nsv516397 CNV Gain 19592680

Variation tolerance for DDO Gene

Residual Variation Intolerance Score: 97.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDO Gene

HapMap Linkage Disequilibrium report
DDO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDO Gene

Disorders for DDO Gene

Relevant External Links for DDO

Genetic Association Database (GAD)
DDO
Human Genome Epidemiology (HuGE) Navigator
DDO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDO
genes like me logo Genes that share disorders with DDO: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDO Gene

Publications for DDO Gene

  1. Structural and functional characterization of the human brain D- aspartate oxidase. (PMID: 9163533) Setoyama C. … Miura R. (J. Biochem. 1997) 2 23 67
  2. No association between the D-aspartate oxidase locus and schizophrenia. (PMID: 19125110) Jamra R.A. … Schumacher J. (Psychiatr. Genet. 2009) 23 67
  3. Reproductive implication of D-aspartic acid in human pre-ovulatory follicular fluid. (PMID: 17951582) D'Aniello G. … Ronsini S. (Hum. Reprod. 2007) 23 67
  4. Engineering the substrate specificity of porcine kidney D-amino acid oxidase by mutagenesis of the "active-site lid". (PMID: 16751595) Setoyama C. … Miura R. (J. Biochem. 2006) 23 67
  5. Cloning and expression in Escherichia coli of the D-aspartate oxidase gene from the yeast Cryptococcus humicola and characterization of the recombinant enzyme. (PMID: 15115779) Takahashi S. … Yamada R.H. (J. Biochem. 2004) 23 67

Products for DDO Gene

Sources for DDO Gene

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