Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDO Gene

protein-coding   GIFtS: 57
GCID: GC06M110672

D-aspartate oxidase
 Explore 3 diseases affiliated with
DDO via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DDO    

Aliases
for DDO gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
D-Aspartate Oxidase1 2     DDO-22
DASOX2 3     Aspartic Oxidase2
EC 1.4.3.13 8     D-Aspartate Oxidase, DDO2
DDO-12     

External Ids:    HGNC: 27271   Entrez Gene: 85282   Ensembl: ENSG000002037977   OMIM: 1244505   UniProtKB: Q994893   

Export aliases for DDO gene to outside databases

Previous GC identifers: GC06M110539 GC06M110736 GC06M110758 GC06M110820 GC06M108280


Summaries
for DDO gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DDO:
The protein encoded by this gene is a peroxisomal flavoprotein that catalyzes the oxidative deamination of D-aspartate
and N-methyl D-aspartate. Flavin adenine dinucleotide or 6-hydroxyflavin adenine dinucleotide can serve as the
cofactor in this reaction. Two transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OXDD_HUMAN, Q99489
Function: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl
D-aspartate

Gene Wiki entry for DDO


Genomic Views
for DDO gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDO gene promoter:
         MEF-2   HNF-1A   AREB6   MEF-2A   HNF-1   Cart-1   aMEF-2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDO promoter sequence
   Search SABiosciences Chromatin IP Primers for DDO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q22.1

DDO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDO gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M110672:  view genomic region     (about GC identifiers)

Start:
 110,712,974 bp from pter      End:
 110,740,732 bp from pter
Size:
 27,759 bases      Orientation:
 minus strand

Proteins
for DDO gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OXDD_HUMAN, Q99489 (See protein sequence)
Recommended Name: D-aspartate oxidase  
Size: 341 amino acids; 37535 Da
Cofactor: FAD or 6-hydroxyflavin adenine dinucleotide
Subcellular location: Peroxisome
Secondary accessions: A8KAG4 Q5JXM4 Q5JXM5 Q5JXM6 Q8N552
Alternative splicing: 4 isoforms:  Q99489-1   Q99489-2   Q99489-3   Q99489-4   (Ref.6 (DN990727) sequence is in conflict in position: 9:T->N)

Explore the universe of human proteins at neXtProt for DDO: NX_Q99489

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99489

    • 2 DME Specific Peptides for DDO (Q99489)
     VVHHYGHG  VTLGGTRQKGDWN 

    DDO Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_003640.2  NP_004023.2  

    ENSEMBL proteins: 
     ENSP00000357920   ENSP00000357919   ENSP00000436642   ENSP00000357921  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: DDO
    OriGene Protein Over-expression Lysate (see all 3): DDO
    OriGene Custom Protein Services for DDO 
    GenScript Custom Purified and Recombinant Proteins Services for DDO
    Novus Biologicals DDO Proteins
    Novus Biologicals DDO Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DDO

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome NAS9820813


    DDO for ontologies           About GeneDecksing



    DDO Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DDO 
    GenScript Custom Superior Antibodies Services for DDO
    Novus Biologicals DDO Antibodies
    Search for Antibodies for DDO at Abcam  
    Uscn Antibodies for DDO
    ThermoFisher Antibody for DDO

    Assay Products for DDO: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDO
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DDO

    Protein Domains /
    Families
    for DDO gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DDO for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006076 FAD-dep_OxRdtase
     IPR006181 D-amino_acid_oxidase_CS
     IPR023209 D-aa_oxidase

    Graphical View of Domain Structure for InterPro Entry Q99489

    ProtoNet protein and cluster: Q99489

    1 Blocks protein family: IPB006181 D-amino acid oxidase

    UniProtKB/Swiss-Prot: OXDD_HUMAN, Q99489
    Similarity: Belongs to the DAMOX/DASOX family


    Function
    for DDO gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OXDD_HUMAN, Q99489
    Function: Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl
    D-aspartate
    Catalytic activity: D-aspartate + H(2)O + O(2) = oxaloacetate + NH(3) + H(2)O(2)

    Enzyme Number (IUBMB): EC 1.4.3.11 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): DDO
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDO
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate DDO:
    hsa-miR-587 hsa-miR-590-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: DDO 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDO (see all 7)
    OriGene shRNA RFP: DDO
    OriGene siRNA: DDO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDO

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DDO

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDO (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDO (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DDO (NM_005216)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDO 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for DDO
    Search LifeMap BioReagents cell lines for DDO

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDO

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003884D-amino-acid oxidase activity IEA--
    GO:0005102receptor binding IPI--
    GO:0005515protein binding IPI9820813
    GO:0008445D-aspartate oxidase activity IDA--


    DDO for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for DDO: Ddotm1Rdl Ddotm1Snyd
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ddo):
     behavior/neurological  endocrine/exocrine gland  growth/size  homeostasis/metabolism  nervous system 
     reproductive system 

    DDO for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DDO gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Alanine, aspartate and glutamate metabolism
    		Alanine, aspartate and glutamate metabolism1.00
    2Peroxisome
    		Peroxisome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for DDO):
        Alanine, aspartate and glutamate metabolism
    Peroxisome


    DDO for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for DDO (Q994893 ENSP000003579204) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PEX5P505423, ENSP000004074014I2D: score=1 STRING: ENSP00000407401
    IL4I1ENSP000003425574STRING: ENSP00000342557
    GOT1ENSP000003595394STRING: ENSP00000359539
    GOT2ENSP000002452064STRING: ENSP00000245206
    NIT2ENSP000003776964STRING: ENSP00000377696
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006531aspartate metabolic process IEA--
    GO:0006533aspartate catabolic process IDA9163533
    GO:0007320insemination IEA--
    GO:0007625grooming behavior IEA--
    GO:0019478D-amino acid catabolic process IDA--


    DDO for ontologies           About GeneDecksing



    Drugs & Compounds
    for DDO gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DDO for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDO

    7 HMDB Compounds for DDO    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    D-Aspartic acid(-)-Aspartic acid (see all 19)1783-96-6--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    Hydrogen peroxideHydrogen peroxide (see all 44)7722-84-1--
    Oxalacetic acid2-Ketosuccinate (see all 20)328-42-7--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    3 Novoseek chemical compound relationships for DDO gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pipecolic acid 79.5 1 8556358 (1)
    aspartate 74.3 34 9820813 (3), 11713869 (3), 12209855 (3), 9163533 (2) (see all 14)
    nmda 21.1 1 9163533 (1)

    Search CenterWatch for drugs/clinical trials and news about DDO / OXDD 

    Transcripts
    for DDO gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDO gene (2 alternative transcripts): 
    NM_003649.2  NM_004032.2  

    Unigene Cluster for DDO:

    D-aspartate oxidase
    Hs.591348  [show with all ESTs]
    Unigene Representative Sequence: NM_003649
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368924(uc003puc.3) ENST00000368923(uc003pud.3) ENST00000479373
    ENST00000368925

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): DDO
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDO
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate DDO:
    hsa-miR-587 hsa-miR-590-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmid: DDO 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDO (see all 7)
    OriGene shRNA RFP: DDO
    OriGene siRNA: DDO
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDO
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDO (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDO (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DDO (NM_005216)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDO 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDO
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDO
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDO
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDO

    Additional cDNA sequence: 

    AB496420.1 AK293029.1 BC032786.1 D89858.1 

    3 DOTS entries:

    DT.310390  DT.100746843  DT.121322695 

    24/46 AceView cDNA sequences (see all 46):

    AL553190 NM_004032 BX489908 NM_003649 BF436252 BM544810 D89858 AI733581 
    AX786391 AA555279 CR590300 BM807293 T26465 AL576258 BE502807 BI517640 
    BE277493 CD677087 BI765288 AI792161 AI470186 AA994974 BX500405 CD251036 

    GeneLoc Exon Structure


    Expression
    for DDO gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGCTTACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DDO expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    AdiposeInterscapular Brown Adipose DepotAdipose
    AdiposeThoracic Perivascular AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primordial germ cell-like cells (Reconstitution of mo...)

    See DDO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDO

    SOURCE GeneReport for Unigene cluster: Hs.591348
        SABiosciences Custom PCR Arrays for DDO
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDO
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDO
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDO
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDO
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDO

    Orthologs
    for DDO gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DDO gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DDO1 D-aspartate oxidase 66.76(n)
    64.22(a)    		   770953  XM_001234268.1  XP_001234269.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DDO6
    		 --
    		 65(a)
    		 1 ↔ 1
    		 1(191743314-191748050)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003327331 d-aspartate oxidase-like 58.87(n)
    55.08(a)    		   100332733  XM_002665140.1  XP_002665186.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG112363
    CG123381    		 D-aspartate oxidase3
    CG123381    		 35(a)3
    48.79(n)1
    40.06(a)1    		   27B13
    361281  NM_136759.21  NP_610603.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y69A2AR.53
    daao-11    		 Protein DAAO-11 37(a)3
    46.62(n)1
    40.52(a)1    		   IV(2614205-2617036)3
    35657751  NM_067833.41  NP_500234.31 
    K. lactis yeast
    (Kluyveromyces lactis)    		 Saccharomycetes KLLA0A02475g1 hypothetical protein 41.8(n)
    31.11(a)    		   2896688  XM_451109.1  XP_451109.1 


    ENSEMBL Gene Tree for DDO (if available)
    TreeFam Gene Tree for DDO (if available) 

    Paralogs
    for DDO gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDO gene
    DAO2  
    3 SIMAP similar genes for DDO using alignment to 2 protein entries:     OXDD_HUMAN (see all proteins):
    ddo    DAO    DKFZp686F04272

    DDO for paralogs           About GeneDecksing



    Genomic Variants
    for DDO gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/533 NCBI SNPs in DDO are shown (see all 533)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1460128511,2
    		--110712898(+) TTTCCA/GTCCAC 2 -- ds50010--------
    rs93741701,2
    		C,F,A,H,--110712991(+) ATTTAA/GCTCAA 2 -- ds500115Minor allele frequency- G:0.48NS EA NA CSA WA 787
    rs10553011,2
    		C,F,A,H,--110713042(-) AAGTAT/CTGGGG 2 -- ds500116Minor allele frequency- C:0.45MN NS EA NA CSA WA 965
    rs412885881,2
    		C,--110713060(+) AACTGA/C/TGGAGT 2 -- ds50011NA 2
    rs1493330911,2
    		--110713103(+) CCACCC/TTAATT 2 -- ds50010--------
    rs765291521,2
    		F,--110713231(+) TGTTTG/AACCCC 2 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1446660611,2
    		--110713382(+) GCACTA/GTGTGA 2 -- ds50010--------
    rs1931306161,2
    		--110713413(+) GAGGAA/CTTATG 2 -- ut310--------
    rs1133891331,2
    		--110713460(+) AGCTCA/TGCAAT 2 -- ut312Minor allele frequency- T:0.33CSA 3
    rs1428134701,2
    		--110713492(+) CCATAC/TATTAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DDO (110712974 - 110740732 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for DDO
         5 CNVs: 81546 93957 93958 93959 81545

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDO
    DNA2.0 Custom Variant and Variant Library Synthesis for DDO

    Disorders / Diseases
    for DDO gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DDO for disorders           About GeneDecksing

    OMIM gene information: 124450    OMIM disorders: --

    3 diseases for DDO:    About MalaCards
    schizophrenia    tuberculosis    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: DDO (2 documents)

    Export disorders for DDO gene to outside databases

    Publications
    for DDO gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDO gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with DDO)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural and functional characterization of the human brain D- aspartate oxidase. (PubMed id 9163533)1, 2, 3, 9 Setoyama C. and Miura R. (1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain. (PubMed id 12209855)1, 9 Zaar K....Fahimi H.D. (2002)
    5. C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome-targeting signal. (PubMed id 9820813)1, 9 Amery L....Van Veldhoven P.P. (1998)
    6. D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man. (PubMed id 1991137)1, 9 Van Veldhoven P.P....Mannaerts G.P. (1991)
    7. No association between the D-aspartate oxidase locus and schizophrenia. (PubMed id 19125110)1, 9 Jamra R.A....Schumacher J. (2009)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Comparative characterization of three D-aspartate oxi dases and one D-amino acid oxidase from Caenorhabditis elegans. (PubMed id 20564561)1 Katane M....Homma H. (2010)
    10. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1 Joslyn G....White R.L. (2010)

    External Searches for DDO gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DDO gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8528 HGNC: 2727 AceView: DDO Ensembl:ENSG00000203797 euGenes: HUgn8528
    ECgene: DDO Kegg: 8528 H-InvDB: DDO

    Other Databases showing DDO gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDO gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDO Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DDO gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDO gene:
    Search GeneIP for patents involving DDO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for DDO gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for DDO  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDO   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDO  
     OriGene Protein Over-expression Lysate for DDO   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for DDO   OriGene 3'-UTR Clone for DDO  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDO   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDO  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for DDO   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDO   OriGene Custom Protein Services for DDO  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDO
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDO
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDO
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDO
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDO
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDO
     GenScript Custom Purified and Recombinant Proteins Services for DDO GenScript cDNA clones with any tag delivered in your preferred vector for DDO
     GenScript Custom Assay Services for DDO GenScript Custom Superior Antibodies Services for DDO
     GenScript Custom overexpressing Cell Line Services for DDO CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DDO promoter
     Search Chromatin IP Primers for DDO
     RT2 qPCR Primer Assay in human, mouse, rat DDO
     Search GNC Networks for DDO
     SABiosciences Custom PCR Arrays for DDO
     Search Tocris compounds for DDO
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DDO antibodies
     DDO proteins
     DDO lysates
     Search for Antibodies for DDO at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DDO
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     DDO Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for DDO
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDO
     SwitchGear 3'UTR luciferase reporter plasmids for DDO
     SwitchGear Promoter luciferase reporter plasmids for DDO
     ThermoFisher Antibody for DDO
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDO
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      DDO gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4