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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DDN Gene

protein-coding GIFtS: 49
GCID: GC12M049388

dendrin

Explore 4 diseases affiliated with
DDN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dendrin¹
KIAA0749¹ ³ ⁵

External Ids:	HGNC: 24458¹	Entrez Gene: 23109²	Ensembl: ENSG00000181418⁷	OMIM: 610588⁵	UniProtKB: O94850³

Export aliases for DDN gene to outside databases

Previous GC identifers: GC12M049105 GC12M047675 GC12M046420

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DEND_HUMAN, O94850

Function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the

ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DDN gene promoter:
C/EBPbeta HOXA3 CUTL1 AP-2gamma SREBP-1b Egr-2 SREBP-1a AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDN promoter sequence

Search SABiosciences Chromatin IP Primers for DDN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13

DDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDN gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M049388: view genomic region (about GC identifiers)

Start:	49,388,932 bp from pter	End:	49,393,092 bp from pter
Size:	4,161 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DEND_HUMAN, O94850 (See protein sequence)

Recommended Name: Dendrin

Size: 711 amino acids; 75996 Da

Subunit: Forms a ternary complex with MAGI2 and SH3KBP1; recruits DDN to the cytoplasm. Interacts with MAGI1. Interacts

with ACTN1 and may interact with WWC1. Interacts with the podocyte slit diaphragm proteins CD2AP, NPHS1 and NPHS2; the

interaction with CD2AP and NPHS1 is direct (By similarity)

Subcellular location: Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic

reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Perikaryon (By similarity). Nucleus

(By similarity). Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes

and associated with polyribosomes in dendrites (By similarity)

Sequence caution: Sequence=BAA34469.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for DDN: NX_O94850

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O94850

DDN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_055901.2

ENSEMBL proteins:

ENSP00000390590

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Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	16464232
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0030425	dendrite	--	--
GO:0032591	dendritic spine membrane	IEA	--

DDN for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DDN for domains About GeneDecksing

1 InterPro domain/family:

IPR026500 Dendrin

Graphical View of Domain Structure for InterPro Entry O94850

ProtoNet protein and cluster: O94850

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DEND_HUMAN, O94850

Function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the

ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16751601

DDN for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for DDN:

Actin fiber cells

Increased gamma-H2AX phosphory

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ddn):

renal/urinary system

DDN for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ddn^tm1Ktry for DDN

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		hsa-miR-323-3p hsa-miR-485-5p hsa-miR-1321 hsa-miR-642a hsa-miR-4318 hsa-let-7d hsa-miR-24-1* hsa-miR-3616-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DDN 3' UTR sequence

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DDN

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/7 Interacting proteins for DDN (O94850^{1, 2, 3} ENSP00000390590⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SH3KBP1	Q96B97¹^,²^,³, ENSP00000380921⁴	EBI-5240523,EBI-346595 MINT-7137832 MINT-7137718 MINT-7137805 MINT-7137666 MINT-7137751 MINT-7137684 I2D: score=1 STRING: ENSP00000380921
MAGI2	Q86UL8³, ENSP00000346151⁴	I2D: score=1 STRING: ENSP00000346151
WWC1	Q8IX03³, ENSP00000265293⁴	I2D: score=1 STRING: ENSP00000265293
MAGI1	ENSP00000385450⁴	STRING: ENSP00000385450
ACTN1	ENSP00000377941⁴	STRING: ENSP00000377941

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DDN
Search CenterWatch for drugs/clinical trials and news about DDN / DEND

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DDN gene:

NM_015086.1

Unigene Cluster for DDN:

Dendrin

Hs.591044 [show with all ESTs]

Unigene Representative Sequence: BC039264

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000421952(uc001rsv.1)

miRNA Products:		OriGene 3'-UTR Clone: DDN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDN
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		hsa-miR-323-3p hsa-miR-485-5p hsa-miR-1321 hsa-miR-642a hsa-miR-4318 hsa-let-7d hsa-miR-24-1* hsa-miR-3616-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DDN 3' UTR sequence

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Additional cDNA sequence:

AB018292.1 BC039264.1 BC136398.1 BC136399.1

5 DOTS entries:

DT.400789 DT.100650370 DT.100719732 DT.100719731 DT.121192237

3 AceView cDNA sequences:

AB018292 CR591956 BC039264

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DDN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAACTTGGC

About this image

DDN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Glomerulus

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DDN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDN

SOURCE GeneReport for Unigene cluster: Hs.591044

UniProtKB/Swiss-Prot: DEND_HUMAN, O94850

Tissue specificity: Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at

protein level)

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DDN gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ddn^{1 , 5}	dendrin^{1, 5}	81.12(n)¹ 77.82(a)¹		15 (54.69 cM)⁵ 13199¹ NM_001013741.1¹ NP_001013763.1¹ 98803782⁵
lizard (Anolis carolinensis)	Reptilia	DDN⁶	--	34(a)	1 ↔ 1	2(93992945-93994252)

ENSEMBL Gene Tree for DDN (if available)
TreeFam Gene Tree for DDN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139319437^1,2		--	49388567(+)	`TCTGGA/GTTGGA`	1	--	ds500¹		0	--	--	--	--
rs150015314^1,2		--	49388685(+)	`CCCGGA/CTGACT`	1	--	ds500¹		0	--	--	--	--
rs186726986^1,2		--	49389226(+)	`CCCGGA/CGGGCT`	1	--	ut3¹		0	--	--	--	--
rs190684787^1,2		--	49389279(+)	`GGCTGA/GAGACT`	1	--	ut3¹		0	--	--	--	--
rs1054442^1,2	C,F,A,H	--	49389320(-)	`AATCCT/GATCCC`	1	--	ut3¹		23		EA MN NS WA NA CSA	4012
rs10875907^1,2	C,F	--	49389410(+)	`CCCACG/ACCTGC`	1	--	ut3¹		1		NA	120
rs3741619^1,2	C,F,H	--	49389476(+)	`GATGGG/AAGAAA`	1	--	ut3¹		19		EA NS NA WA CSA	3282
rs74891052^1,2	C,F	--	49389571(+)	`NNNNGG/AAAAAG`	1	--	ut3¹		1		NA	120
rs115903631^1,2		--	49389848(+)	`TTCTTG/AGCTTG`	1	--	ut3¹		1		WA	118
rs181927130^1,2		--	49389918(+)	`ATGGAA/CCTTAG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DDN (49388932 - 49393092 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DDN
1 CNV: 4777
1 Indel: 58574

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDN

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DDN for disorders           About GeneDecksing

OMIM gene information: 610588    OMIM disorders: --

4 diseases for DDN:    About MalaCards

mental retardation syndrome glomerulopathy nephrotic syndrome neuronitis

Human Genome Epidemiology (HuGE) Navigator: DDN (3 documents)

Export disorders for DDN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DDN gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with DDN)

Utopia: connect your pdf to the dynamic
world of online information

Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome. (PubMed id 18356187)^{1, 2, 9} Duner F.... Wernerson A. (2008)
Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring. (PubMed id 16464232)^{1, 2, 9} Kremerskothen J.... Barnekow A. (2006)
Characterization of KIBRA, a novel WW domain-containing protein. (PubMed id 12559952)^{1, 2, 9} Kremerskothen J.... Barnekow A. (2003)
CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin. (PubMed id 16751601)^{1, 2} Kawata A.... Hata Y. (2006)
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)^{1, 2} Nagase T.... Ohara O. (1998)
Dendrin location in podocytes is associated with dise ase progression in animal and human glomerulopathy. (PubMed id 21606645)¹ Asanuma K....Tomino Y. (2011)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
Expression and subcellular distribution of novel glomerulus- associated proteins Dendrin, Ehd3, Sh2d4a, Plekhh2, and 2310066E14Rik. (PubMed id 17251388)² Patrakka J.... Tryggvason K. (2007)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23109	HGNC: 24458	AceView: DDN	Ensembl:ENSG00000181418	euGenes: HUgn23109
ECgene: DDN	H-InvDB: DDN

(According to HUGE)
About This Section

HUGE: KIAA0749

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DDN	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DDN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DDN gene:
Search GeneIP for patents involving DDN

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for DDN
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDN		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDN
	OriGene Protein Over-expression Lysate for DDN		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DDN		OriGene 3'-UTR Clone for DDN
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDN		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDN
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DDN		OriGene Custom Protein Services for DDN
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDN
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDN
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDN
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDN
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDN
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDN

	GenScript Custom Purified and Recombinant Proteins Services for DDN		GenScript cDNA clones with any tag delivered in your preferred vector for DDN
	GenScript Custom Assay Services for DDN		GenScript Custom Superior Antibodies Services for DDN
	GenScript Custom overexpressing Cell Line Services for DDN		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DDN promoter
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	Browse Sino Biological Proteins and Antibodies
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Biologicals
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	Search for Antibodies for DDN at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for DDN
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DDN Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDN

	SwitchGear 3'UTR luciferase reporter plasmids for DDN
	SwitchGear Promoter luciferase reporter plasmids for DDN

Search ThermoFisher Antibodies for DDN

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDN

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DDN

Sirion Biotech Customized:

	stable knockdown cell line services for DDN
	inducible knockdown cell line services for DDN
	design and validation of potent shRNA sequences against DDN
	adenovirus for potent knockdown of DDN
	adenovirus for overexpression of DDN
	stable overexpressing cell line services for DDN
	inducible overexpressing cell line services for DDN

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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DDN Gene

dendrin

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DDN Gene

dendrin

Aliasesfor DDN gene

Summariesfor DDN gene

Genomic Viewsfor DDN gene

Proteinsfor DDN gene

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Functionfor DDN gene

Pathways & Interactionsfor DDN gene

Drugs & Compoundsfor DDN gene

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Orthologsfor DDN gene

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Genome Databases showing DDN gene

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Specialized Databases showing DDN gene

Intellectual Propertyfor DDN gene

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View Random Gene

Aliases
for DDN gene

Summaries
for DDN gene

Genomic Views
for DDN gene

Proteins
for DDN gene

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Families
for DDN gene

Function
for DDN gene

Pathways & Interactions
for DDN gene

Drugs & Compounds
for DDN gene

Transcripts
for DDN gene

Expression
for DDN gene

Orthologs
for DDN gene

Paralogs
for DDN gene

Genomic Variants
for DDN gene

Disorders / Diseases
for DDN gene

Publications
for DDN gene

Intellectual Property
for DDN gene

Products
for DDN gene