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Aliases for DDN Gene

Aliases for DDN Gene

  • Dendrin 2 3 3 5
  • KIAA0749 4

External Ids for DDN Gene

Previous GeneCards Identifiers for DDN Gene

  • GC12M049105
  • GC12M047675
  • GC12M049388
  • GC12M046420

Summaries for DDN Gene

GeneCards Summary for DDN Gene

DDN (Dendrin) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding.

UniProtKB/Swiss-Prot for DDN Gene

  • Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDN Gene

Genomics for DDN Gene

Regulatory Elements for DDN Gene

Enhancers for DDN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G049055 1.8 FANTOM5 ENCODE dbSUPER 20 -57.4 -57412 6.7 CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 DDX23 LOC390314 CCNT1 KANSL2 SENP1 PRPF40B DDN LOC100422296 LOC101927267 CCDC184
GH12G049017 1.1 ENCODE 30.8 -17.9 -17931 4.0 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 DDN DDX23 CCNT1 LOC390314 CACNB3 PRPF40B SENP1 PRKAG1
GH12G049063 1.1 Ensembl ENCODE 30 -63.0 -63010 0.6 HDAC1 HDGF PKNOX1 CBX3 SIN3A ZSCAN9 RAD21 YY1 RFX5 ZNF143 DDN GC12M049057 RHEBL1
GH12G048996 0.8 ENCODE 30.3 +4.2 4189 0.2 ATF1 RB1 TBL1XR1 ARID4B ZNF48 ZSCAN9 RAD21 YY1 ZNF143 CREM DDN DDN-AS1 ENSG00000258283
GH12G049068 1.1 ENCODE 20.5 -68.8 -68755 1.7 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B DDN CACNB3 PRPF40B RHEBL1 GC12M049057
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDN on UCSC Golden Path with GeneCards custom track

Promoters for DDN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051561 1791 201 HDAC1 ZSCAN4 SIN3A GLIS2 EGR1 ZNF366 ZNF143 PCBP1 KLF7 ETV6

Genomic Location for DDN Gene

Chromosome:
12
Start:
48,995,149 bp from pter
End:
49,001,091 bp from pter
Size:
5,943 bases
Orientation:
Minus strand

Genomic View for DDN Gene

Genes around DDN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDN Gene

Proteins for DDN Gene

  • Protein details for DDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94850-DEND_HUMAN
    Recommended name:
    Dendrin
    Protein Accession:
    O94850

    Protein attributes for DDN Gene

    Size:
    711 amino acids
    Molecular mass:
    75996 Da
    Quaternary structure:
    • Forms a ternary complex with MAGI2 and SH3KBP1; recruits DDN to the cytoplasm. Interacts with MAGI1. Interacts with ACTN1 and may interact with WWC1. Interacts with the podocyte slit diaphragm proteins CD2AP, NPHS1 and NPHS2; the interaction with CD2AP and NPHS1 is direct (By similarity).
    SequenceCaution:
    • Sequence=BAA34469.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DDN Gene

Post-translational modifications for DDN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDN Gene

Domains & Families for DDN Gene

Protein Domains for DDN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DDN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DDN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DDN Gene

Function for DDN Gene

Molecular function for DDN Gene

UniProtKB/Swiss-Prot Function:
Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).

Gene Ontology (GO) - Molecular Function for DDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0005515 protein binding IPI 16464232
genes like me logo Genes that share ontologies with DDN: view
genes like me logo Genes that share phenotypes with DDN: view

Animal Models for DDN Gene

MGI Knock Outs for DDN:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DDN
  • Applied Biological Materials Clones for DDN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDN Gene

Localization for DDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDN Gene

Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Nucleus. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDN gene
Compartment Confidence
nucleus 5
plasma membrane 3
endoplasmic reticulum 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
GO:0005737 cytoplasm IEA,IDA 16464232
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with DDN: view

Pathways & Interactions for DDN Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with DDN: view

No data available for Pathways by source and SIGNOR curated interactions for DDN Gene

Drugs & Compounds for DDN Gene

No Compound Related Data Available

Transcripts for DDN Gene

mRNA/cDNA for DDN Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDN Gene

Dendrin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DDN
  • Applied Biological Materials Clones for DDN

Alternative Splicing Database (ASD) splice patterns (SP) for DDN Gene

No ASD Table

Relevant External Links for DDN Gene

GeneLoc Exon Structure for
DDN
ECgene alternative splicing isoforms for
DDN

Expression for DDN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDN Gene

This gene is overexpressed in Muscle - Skeletal (x8.6), Brain - Amygdala (x6.0), Brain - Nucleus accumbens (basal ganglia) (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.8), Brain - Cortex (x5.6), Brain - Putamen (basal ganglia) (x4.9), Brain - Hippocampus (x4.8), Brain - Frontal Cortex (BA9) (x4.6), and Brain - Caudate (basal ganglia) (x4.5).

Protein differential expression in normal tissues from HIPED for DDN Gene

This gene is overexpressed in Salivary gland (45.7) and Heart (23.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DDN Gene



Protein tissue co-expression partners for DDN Gene

NURSA nuclear receptor signaling pathways regulating expression of DDN Gene:

DDN

SOURCE GeneReport for Unigene cluster for DDN Gene:

Hs.591044

mRNA Expression by UniProt/SwissProt for DDN Gene:

O94850-DEND_HUMAN
Tissue specificity: Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level).

Evidence on tissue expression from TISSUES for DDN Gene

  • Nervous system(4.6)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with DDN: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DDN Gene

Orthologs for DDN Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDN 34 35
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia DDN 34 35
  • 85.47 (n)
dog
(Canis familiaris)
Mammalia DDN 34 35
  • 84.81 (n)
mouse
(Mus musculus)
Mammalia Ddn 34 16 35
  • 81.03 (n)
rat
(Rattus norvegicus)
Mammalia Ddn 34
  • 80.24 (n)
lizard
(Anolis carolinensis)
Reptilia DDN 35
  • 33 (a)
OneToOne
Species where no ortholog for DDN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DDN Gene

ENSEMBL:
Gene Tree for DDN (if available)
TreeFam:
Gene Tree for DDN (if available)

Paralogs for DDN Gene

No data available for Paralogs for DDN Gene

Variants for DDN Gene

Sequence variations from dbSNP and Humsavar for DDN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000060268 -- 48,995,518(+) GACCC(C/G)CGCTC utr-variant-3-prime
rs1000594281 -- 48,997,406(+) TGGCT(A/G)GGGGA upstream-variant-2KB, reference, synonymous-codon
rs1000603715 -- 48,999,503(+) GCCGC(C/G)CCCTG intron-variant, upstream-variant-2KB
rs1001545392 -- 48,999,541(+) CTGCT(C/G)TTGTC intron-variant, upstream-variant-2KB
rs1001717698 -- 48,998,371(+) AGGCG(C/T)CAGGC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DDN Gene

Variant ID Type Subtype PubMed ID
nsv558833 CNV loss 21841781
nsv820277 CNV gain 19587683
nsv832404 CNV gain 17160897

Variation tolerance for DDN Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.34; 85.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDN Gene

Disorders for DDN Gene

Relevant External Links for DDN

Genetic Association Database (GAD)
DDN
Human Genome Epidemiology (HuGE) Navigator
DDN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDN

No disorders were found for DDN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDN Gene

Publications for DDN Gene

  1. Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome. (PMID: 18356187) Duner F. … Wernerson A. (Nephrol. Dial. Transplant. 2008) 3 4 22 64
  2. Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring. (PMID: 16464232) Kremerskothen J. … Barnekow A. (J. Neurochem. 2006) 3 4 22 64
  3. Characterization of KIBRA, a novel WW domain-containing protein. (PMID: 12559952) Kremerskothen J. … Barnekow A. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin. (PMID: 16751601) Kawata A. … Hata Y. (J. Biochem. 2006) 3 4 64

Products for DDN Gene

  • Addgene plasmids for DDN

Sources for DDN Gene

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