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Aliases for DDN Gene

Aliases for DDN Gene

  • Dendrin 2 3
  • KIAA0749 4 6

External Ids for DDN Gene

Summaries for DDN Gene

GeneCards Summary for DDN Gene

DDN (Dendrin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DDN Gene

  • Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDN Gene

Genomics for DDN Gene

Genomic Location for DDN Gene

Start:
48,995,149 bp from pter
End:
48,999,309 bp from pter
Size:
4,161 bases
Orientation:
Minus strand

Genomic View for DDN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDN Gene

Proteins for DDN Gene

  • Protein details for DDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94850-DEND_HUMAN
    Recommended name:
    Dendrin
    Protein Accession:
    O94850
    Secondary Accessions:

    Protein attributes for DDN Gene

    Size:
    711 amino acids
    Molecular mass:
    75996 Da
    Quaternary structure:
    • Forms a ternary complex with MAGI2 and SH3KBP1; recruits DDN to the cytoplasm. Interacts with MAGI1. Interacts with ACTN1 and may interact with WWC1. Interacts with the podocyte slit diaphragm proteins CD2AP, NPHS1 and NPHS2; the interaction with CD2AP and NPHS1 is direct (By similarity).
    SequenceCaution:
    • Sequence=BAA34469.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DDN Gene

Proteomics data for DDN Gene at MOPED

Post-translational modifications for DDN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDN Gene

Domains for DDN Gene

Protein Domains for DDN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DDN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DDN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DDN Gene

Function for DDN Gene

Molecular function for DDN Gene

UniProtKB/Swiss-Prot Function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).

Gene Ontology (GO) - Molecular Function for DDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000982 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16464232
genes like me logo Genes that share ontologies with DDN: view

Phenotypes for DDN Gene

MGI mutant phenotypes for DDN:
inferred from 1 alleles
GenomeRNAi human phenotypes for DDN:
genes like me logo Genes that share phenotypes with DDN: view

Animal Models for DDN Gene

MGI Knock Outs for DDN:

miRNA for DDN Gene

miRTarBase miRNAs that target DDN

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DDN Gene

Localization for DDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDN Gene

Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Perikaryon. Nucleus. Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the foot process of podocytes and associated with polyribosomes in dendrites. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDN Gene COMPARTMENTS Subcellular localization image for DDN gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
nucleus 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 16464232
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane --
genes like me logo Genes that share ontologies with DDN: view

Pathways for DDN Gene

SuperPathways for DDN Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with DDN: view

No data available for Pathways by source for DDN Gene

Transcripts for DDN Gene

mRNA/cDNA for DDN Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDN Gene

Dendrin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDN Gene

No ASD Table

Relevant External Links for DDN Gene

GeneLoc Exon Structure for
DDN
ECgene alternative splicing isoforms for
DDN

Expression for DDN Gene

mRNA expression in normal human tissues for DDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDN Gene

This gene is overexpressed in Muscle - Skeletal (8.6), Brain - Amygdala (6.0), Brain - Nucleus accumbens (basal ganglia) (5.8), Brain - Anterior cingulate cortex (BA24) (5.8), Brain - Cortex (5.6), Brain - Putamen (basal ganglia) (4.9), Brain - Hippocampus (4.8), Brain - Frontal Cortex (BA9) (4.6), and Brain - Caudate (basal ganglia) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DDN Gene

SOURCE GeneReport for Unigene cluster for DDN Gene Hs.591044

mRNA Expression by UniProt/SwissProt for DDN Gene

O94850-DEND_HUMAN
Tissue specificity: Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level).
genes like me logo Genes that share expressions with DDN: view

Orthologs for DDN Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDN 35
  • 99.44 (n)
  • 99.15 (a)
DDN 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDN 35
  • 85.47 (n)
  • 81.04 (a)
DDN 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDN 35
  • 84.81 (n)
  • 79.91 (a)
DDN 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddn 35
  • 81.03 (n)
  • 77.68 (a)
Ddn 16
Ddn 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddn 35
  • 80.24 (n)
  • 76.04 (a)
lizard
(Anolis carolinensis)
Reptilia DDN 36
  • 33 (a)
OneToOne
Species with no ortholog for DDN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DDN Gene

ENSEMBL:
Gene Tree for DDN (if available)
TreeFam:
Gene Tree for DDN (if available)

Paralogs for DDN Gene

No data available for Paralogs for DDN Gene

Variants for DDN Gene

Sequence variations from dbSNP and Humsavar for DDN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1054442 -- 48,995,537(-) AATCC(G/T)ATCCC utr-variant-3-prime
rs3741619 -- 48,995,693(+) GATGG(A/G)AGAAA utr-variant-3-prime
rs3803024 -- 48,997,337(+) GACAG(C/T)CGCTT synonymous-codon, reference
rs4018512 -- 49,000,343(+) TCAAT(A/G)TAGAA upstream-variant-2KB
rs4760659 -- 48,999,198(-) CAGAA(A/G)TCCAA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for DDN Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV Gain 17160897
nsv820277 CNV Gain 19587683

Relevant External Links for DDN Gene

HapMap Linkage Disequilibrium report
DDN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDN Gene

Disorders for DDN Gene

Relevant External Links for DDN

Genetic Association Database (GAD)
DDN
Human Genome Epidemiology (HuGE) Navigator
DDN
genes like me logo Genes that share disorders with DDN: view

No data available for UniProtKB/Swiss-Prot for DDN Gene

Publications for DDN Gene

  1. Characterization of KIBRA, a novel WW domain-containing protein. (PMID: 12559952) Kremerskothen J. … Barnekow A. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  2. Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring. (PMID: 16464232) Kremerskothen J. … Barnekow A. (J. Neurochem. 2006) 3 4 23
  3. Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome. (PMID: 18356187) Duner F. … Wernerson A. (Nephrol. Dial. Transplant. 2008) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for DDN Gene

Sources for DDN Gene

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