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DDN Gene

protein-coding   GIFtS: 49
GCID: GC12M049388

Dendrin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
dendrin1 2
KIAA07493 5

External Ids:    HGNC: 244581   Entrez Gene: 231092   Ensembl: ENSG000001814187   OMIM: 6105885   UniProtKB: O948503   

Export aliases for DDN gene to outside databases

Previous GC identifers: GC12M049105 GC12M047675 GC12M046420


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DDN Gene:
DDN (dendrin) is a protein-coding gene.

UniProtKB/Swiss-Prot: DEND_HUMAN, O94850
Function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to
the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDN gene promoter:
         C/EBPbeta   HOXA3   CUTL1   AP-2gamma   SREBP-1b   Egr-2   SREBP-1a   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDN promoter sequence
   Search Chromatin IP Primers for DDN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13

DDN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDN gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049388:  view genomic region     (about GC identifiers)

Start:
49,388,932 bp from pter      End:
49,393,092 bp from pter
Size:
4,161 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DEND_HUMAN, O94850 (See protein sequence)
Recommended Name: Dendrin  
Size: 711 amino acids; 75996 Da
Subunit: Forms a ternary complex with MAGI2 and SH3KBP1; recruits DDN to the cytoplasm. Interacts with MAGI1.
Interacts with ACTN1 and may interact with WWC1. Interacts with the podocyte slit diaphragm proteins CD2AP, NPHS1
and NPHS2; the interaction with CD2AP and NPHS1 is direct (By similarity)
Sequence caution: Sequence=BAA34469.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for DDN: NX_O94850

Explore proteomics data for DDN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DDN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055901.2  
    ENSEMBL proteins: 
     ENSP00000390590  

    DDN Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DDN

     
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    antibodies-online antibodies for DDN 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026500 Dendrin

    Graphical View of Domain Structure for InterPro Entry O94850

    ProtoNet protein and cluster: O94850


    Find genes that share domains with DDN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DEND_HUMAN, O94850
    Function: Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to
    the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16464232
         
    Find genes that share ontologies with DDN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDN:
     Actin fiber cells  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ddn):
     renal/urinary system 

    Find genes that share phenotypes with DDN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ddntm1Ktry for DDN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDN
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDN

    miRNA
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    miRTarBase miRNAs that target DDN:
    hsa-mir-16-5p (MIRT051128), hsa-mir-335-5p (MIRT018142)

    Block miRNA regulation of human, mouse, rat DDN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDN (see all 29):
    hsa-miR-323-3p hsa-miR-485-5p hsa-miR-1321 hsa-miR-642a hsa-miR-4318 hsa-let-7d hsa-miR-24-1* hsa-miR-3616-5p
    SwitchGear 3'UTR luciferase reporter plasmidDDN 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for DDN 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DEND_HUMAN, O94850: Cell projection, dendritic spine membrane; Peripheral membrane protein. Cytoplasm.
    Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Perikaryon (By
    similarity). Nucleus (By similarity). Note=Enriched at the cytoplasmic insertion of the slit diaphragm into the
    foot process of podocytes and associated with polyribosomes in dendrites (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    nucleus3
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA16464232
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0030425dendrite ----
    GO:0032591dendritic spine membrane IEA--

    Find genes that share ontologies with DDN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDN
    Interactions:

        Search GeneGlobe Interaction Network for DDN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for DDN (O948501, 2, 3 ENSP000003905904) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3KBP1Q96B971, 2, 3, ENSP000003809214EBI-5240523,EBI-346595 MINT-7137832 MINT-7137718 MINT-7137805 MINT-7137666 MINT-7137751 MINT-7137684 I2D: score=1 STRING: ENSP00000380921
    MAGI2Q86UL83, ENSP000003461514I2D: score=1 STRING: ENSP00000346151
    WWC1Q8IX033, ENSP000002652934I2D: score=1 STRING: ENSP00000265293
    ACTN1ENSP000003779414STRING: ENSP00000377941
    MAGI1ENSP000003854504STRING: ENSP00000385450
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDN (DEND)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDN gene: 
    NM_015086.1  

    Unigene Cluster for DDN:

    Dendrin
    Hs.591044  [show with all ESTs]
    Unigene Representative Sequence: BC039264
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000421952(uc001rsv.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DDN (see all 29):
    hsa-miR-323-3p hsa-miR-485-5p hsa-miR-1321 hsa-miR-642a hsa-miR-4318 hsa-let-7d hsa-miR-24-1* hsa-miR-3616-5p
    SwitchGear 3'UTR luciferase reporter plasmidDDN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDN
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    GenScript: all cDNA clones in your preferred vector: DDN (NM_015086)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDN
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      QuantiTect SYBR Green Assays in human, mouse, rat DDN
      QuantiFast Probe-based Assays in human, mouse, rat DDN

    Additional mRNA sequence: 

    AB018292.1 BC039264.1 BC136398.1 BC136399.1 

    5 DOTS entries:

    DT.400789  DT.100650370  DT.100719732  DT.100719731  DT.121192237 

    3 AceView cDNA sequences:

    AB018292 CR591956 BC039264 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAACTTGGC
    DDN Expression
    About this image


    DDN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
    DDN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591044

    UniProtKB/Swiss-Prot: DEND_HUMAN, O94850
    Tissue specificity: Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at
    protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DDN gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddn1 , 5 dendrin1, 5 81.03(n)1
    77.68(a)1
      15 (54.69 cM)5
    131991  NM_001013741.11  NP_001013763.11 
     988037825 
    lizard
    (Anolis carolinensis)
    Reptilia DDN6
    dendrin
    33(a)
    1 ↔ 1
    2(93992945-93994252)


    ENSEMBL Gene Tree for DDN (if available)
    TreeFam Gene Tree for DDN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDN (see all 111)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393194371,2
    --49388567(+) TCTGGA/GTTGGA 1 -- ds50010--------
    rs1500153141,2
    C--49388685(+) CCCGGA/CTGACT 1 -- ds50010--------
    rs1867269861,2
    --49389226(+) CCCGGA/CGGGCT 1 -- ut310--------
    rs1906847871,2
    --49389279(+) GGCTGA/GAGACT 1 -- ut310--------
    rs10544421,2
    C,F,A,H--49389320(-) AATCCT/GATCCC 1 -- ut3123Minor allele frequency- G:0.43EA MN NS WA NA CSA 4012
    rs108759071,2
    C,F--49389410(+) CCCACG/ACCTGC 1 -- ut311Minor allele frequency- A:0.02NA 120
    rs37416191,2
    C,F,H--49389476(+) GATGGG/AAGAAA 1 -- ut3119Minor allele frequency- A:0.37EA NS NA WA CSA 3282
    rs748910521,2
    C,F--49389571(+) TGGAGG/AAAAAG 1 -- ut311Minor allele frequency- A:0.06NA 120
    rs1159036311,2
    C,F--49389848(+) TTCTTG/AGCTTG 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1819271301,2
    --49389918(+) ATGGAA/CCTTAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DDN (49388932 - 49393092 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DDN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820277CNV Gain19587683
    nsv832404CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDN
    DNA2.0 Custom Variant and Variant Library Synthesis for DDN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610588    OMIM disorders: --


    Find genes that share disorders with DDN           About GenesLikeMe

    Genetic Association Database (GAD): DDN
    Human Genome Epidemiology (HuGE) Navigator: DDN (3 documents)

    Export disorders for DDN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDN gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with DDN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dendrin expression in glomerulogenesis and in human minimal change nephrotic syndrome. (PubMed id 18356187)1, 2, 9 Duner F.... Wernerson A. (Nephrol. Dial. Transplant. 2008)
    2. Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring. (PubMed id 16464232)1, 2, 9 Kremerskothen J.... Barnekow A. (J. Neurochem. 2006)
    3. Characterization of KIBRA, a novel WW domain-containing protein. (PubMed id 12559952)1, 2, 9 Kremerskothen J.... Barnekow A. (Biochem. Biophys. Res. Commun. 2003)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin. (PubMed id 16751601)1, 2 Kawata A.... Hata Y. (J. Biochem. 2006)
    6. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    7. Translocation of dendrin to the podocyte nucleus in acute glomerular injury in patients with IgA nephropathy. (PubMed id 23143340)1 Kodama F....Tomino Y. (Nephrol. Dial. Transplant. 2013)
    8. Yes-associated protein (YAP) promotes cell survival by inhibiting proapoptotic dendrin signaling. (PubMed id 23667252)1 Campbell K.N....Mundel P. (J. Biol. Chem. 2013)
    9. Dendrin location in podocytes is associated with disease progression in animal and human glomerulopathy. (PubMed id 21606645)1 Asanuma K....Tomino Y. (Am. J. Nephrol. 2011)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23109 HGNC: 24458 AceView: DDN Ensembl:ENSG00000181418 euGenes: HUgn23109
    ECgene: DDN H-InvDB: DDN

    (According to HUGE)
    About This Section

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    HUGE: KIAA0749

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDN gene:
    Search GeneIP for patents involving DDN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DDN  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DDN  
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     OriGene ORF clones in mouse, rat for DDN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDN   OriGene Custom Protein Services for DDN  

     
     
     Block miRNA regulation of human, mouse, rat DDN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DDN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDN Predesigned siRNA for gene silencing in human, mouse, rat DDN
     QuantiFast Probe-based Assays in human, mouse, rat DDN QuantiTect SYBR Green Assays in human, mouse, rat DDN
     Custom PCR Arrays for DDN Search Chromatin IP Primers for DDN
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDN  Search GeneGlobe Interaction Network for DDN
     Regulatory tfbs in DDN promoter
     GenScript Custom Purified and Recombinant Proteins Services for DDN GenScript cDNA clones with any tag delivered in your preferred vector for DDN
     GenScript Custom Assay Services for DDN GenScript Custom overexpressing Cell Line Services for DDN
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Search for Antibodies & Assays

     Search Tocris compounds for DDN (DEND)
     Browse Sino Biological Proteins
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
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     Search for Antibodies for DDN at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for DDN
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     Proteins for DDN
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     Browse ESI BIO Cell Lines and PureStem Progenitors for DDN
     Gene Synthesis
     Protein Engineering
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDN
     SwitchGear 3'UTR luciferase reporter plasmids for DDN
     SwitchGear Promoter luciferase reporter plasmids for DDN
     Search ThermoFisher Antibodies for DDN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDN
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDN
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDN
     Search LSBio for Antibodies for DDN
     Browse compounds at ApexBio
     Addgene plasmids for DDN
      Search eBioscience for proteins for DDN
      Search eBioscience for elisas for DDN
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
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     Tissue-specific gene expresssion
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     antibodies-online antibodies for DDN
     antibodies-online kits for DDN (6 products)
      Search antibodies-online for peptides for DDN
     antibodies-online proteins for DDN (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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