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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDIT4L Gene

protein-coding   GIFtS: 52
GCID: GC04M101107

DNA-damage-inducible transcript 4-like

 Explore 4 diseases affiliated with
DDIT4L via our new
 Human Malady Compendium 
Biological research products
for DDIT4L
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DNA-Damage-Inducible Transcript 4-Like1 2     HIF-1 Responsive Protein RTP801-Like2 3
REDD21 2 3 5     DNA Damage-Inducible Transcript 4-Like Protein2
Rtp801L1 2     Homolog Of Mouse SMHS12
Protein Regulated In Development And DNA Damage Response 22 3     Regulated In Development And DNA Damage Response 22
REDD-22 3     RTP801L3

External Ids:    HGNC: 305551   Entrez Gene: 1152652   Ensembl: ENSG000001453587   OMIM: 6077305   UniProtKB: Q96D033   

Export aliases for DDIT4L gene to outside databases

Previous GC identifers: GC00U914340 GC04M101567 GC04M101464 GC04M101326 GC04M096845


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03
Function: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream
of AKT1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDIT4L gene promoter:
         SRF   HOXA3   FOXF2   SREBP-1c   Brachyury   SRF (504 AA)   CUTL1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDIT4L promoter sequence
   Search SABiosciences Chromatin IP Primers for DDIT4L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDIT4L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q23

DDIT4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDIT4L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M101107:  view genomic region     (about GC identifiers)

Start:
101,107,027 bp from pter      End:
101,111,939 bp from pter
Size:
4,913 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03 (See protein sequence)
Recommended Name: DNA damage-inducible transcript 4-like protein  
Size: 193 amino acids; 21740 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: B2R7C3

Explore the universe of human proteins at neXtProt for DDIT4L: NX_Q96D03

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96D03

  • DDIT4L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_660287.1  
    ENSEMBL proteins: 
     ENSP00000354830   ENSP00000427301   ENSP00000427040  

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    Uscn Proteins for DDIT4L

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--


    DDIT4L for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DDIT4L for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR012918 RTP801-like

    Graphical View of Domain Structure for InterPro Entry Q96D03

    ProtoNet protein and cluster: Q96D03

    1 Blocks protein family: IPB012918 RTP801

    UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03
    Similarity: Belongs to the DDIT4 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03
    Function: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream
    of AKT1
    Induction: Up-regulated by oxidized LDL and hypoxia in macrophages

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    hsa-miR-21* hsa-miR-607 hsa-miR-429 hsa-miR-1283 hsa-miR-200a hsa-miR-141 hsa-miR-200c hsa-miR-3613-3p
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    1 GenomeRNAi human phenotype for DDIT4L:
     Increased HPV18 LCR reporter a 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mTOR signalling
    TOR signaling0.33


    1 BioSystems Pathway for DDIT4L 
        TOR signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDIT4L

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for DDIT4L (Q96D032, 3 ENSP000003548304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPGP623083, ENSP000002723484I2D: score=3 STRING: ENSP00000272348
    PRKAB2ENSP000002541014STRING: ENSP00000254101
    --Q49AN93, 2MINT-66235 I2D: score=1 
    --Q49AN93, 2MINT-66235 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009968negative regulation of signal transduction IEA--


    DDIT4L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDIT4L
    Search CenterWatch for drugs/clinical trials and news about DDIT4L / DDT4L 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDIT4L gene: 
    NM_145244.3  

    Unigene Cluster for DDIT4L:

    DNA-damage-inducible transcript 4-like
    Hs.480378  [show with all ESTs]
    Unigene Representative Sequence: NM_145244
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273990(uc003hvq.3) ENST00000502763 ENST00000513992

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    hsa-miR-21* hsa-miR-607 hsa-miR-429 hsa-miR-1283 hsa-miR-200a hsa-miR-141 hsa-miR-200c hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidDDIT4L 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK094236.1 AK312926.1 AL832277.1 BC013592.2 

    3 DOTS entries:

    DT.97803632  DT.95359179  DT.100665431 

    24/69 AceView cDNA sequences (see all 69):

    BE613690 CB305849 BE886599 AI624952 AK094236 BF971140 BQ432373 Z43131 
    BX417608 BU552568 CF890855 BQ015667 BE889624 AA528140 BX451396 BM800486 
    AI670890 BQ438284 BM463587 BG428930 BE613468 NM_145244 BM800359 BQ231185 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDIT4L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GATGTAGAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    DDIT4L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    BoneZeugopod Growth PlateBone
    EyeCorneaEye
    Head MesenchymeHead MesenchymeHead Mesenchyme
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (Generation of mesend...)

    See DDIT4L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDIT4L

    SOURCE GeneReport for Unigene cluster: Hs.480378

    UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03
    Tissue specificity: Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery

        SABiosciences Expression via Pathway-Focused PCR Arrays including DDIT4L: 
              mTOR Signaling in human mouse rat
              Hepatotoxicity in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DDIT4L gene from 2/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia DDIT4L6
    --
    71(a)
    1 ↔ 1
    GL343323.1(953501-956650)
    fruit fly
    (Drosophila melanogaster)
    Insecta scyl6
    chrb6
    charybde
    18(a)
    16(a)
    many ↔ many
    many ↔ many
    3L(11245410-11248343)
    3L(11480650-11492212)


    ENSEMBL Gene Tree for DDIT4L (if available)
    TreeFam Gene Tree for DDIT4L (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDIT4L gene
    DDIT42  
    1 SIMAP similar gene for DDIT4L using alignment to 3 protein entries:     DDT4L_HUMAN (see all proteins):
    DDIT4

    DDIT4L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDIT4L
    DNA2.0 Custom Variant and Variant Library Synthesis for DDIT4L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DDIT4L for disorders           About GeneDecksing

    OMIM gene information: 607730    OMIM disorders: --

    4 diseases for DDIT4L:    About MalaCards
    mature teratoma    teratoma    hypoxia    melanoma

    1 disease from the University of Copenhagen DISEASES database for DDIT4L:
    Mature teratoma
    Human Genome Epidemiology (HuGE) Navigator: DDIT4L (1 document)

    Export disorders for DDIT4L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDIT4L gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with DDIT4L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. (PubMed id 15308555)1, 2, 9 Cuaz-Perolin C.... Rouis M. (2004)
    2. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PubMed id 15632201)1, 2, 9 Corradetti M.N.... Guan K.-L. (2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. (PubMed id 12453409)1, 2 Ellisen L.W.... Haber D.A. (2002)
    6. Two-hybrid analysis identifies PSMD11, a non-ATPase s ubunit of the proteasome, as a novel interaction partner of AMP-activated prote in kinase. (PubMed id 19616115)1 Moreno D....Sanz P. (2009)
    7. Genome-wide screen of promoter methylation identifies novel markers in melanoma. (PubMed id 19491193)1 Koga Y....Weissman S.M. (2009)
    8. The regulated in development and DNA damage response 2 (REDD2) gene mediates human monocyte cell death through a reduction in thiore doxin-1 expression. (PubMed id 19268525)1 Imen J.S....Rouis M. (2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115265 HGNC: 30555 AceView: DDIT4L Ensembl:ENSG00000145358 euGenes: HUgn115265
    ECgene: DDIT4L H-InvDB: DDIT4L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDIT4L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDIT4L gene:
    Search GeneIP for patents involving DDIT4L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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