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DDIT4L Gene

protein-coding   GIFtS: 53
GCID: GC04M101107

DNA-Damage-Inducible Transcript 4-Like

  See DDIT4L-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DNA-Damage-Inducible Transcript 4-Like1 2      Similar To Smhs1 Protein1
REDD22 3 5     Rtp801L2
Regulated In Development And DNA Damage Response 21 2     DNA Damage-Inducible Transcript 4-Like Protein2
Protein Regulated In Development And DNA Damage Response 22 3     Homolog Of Mouse SMHS12
REDD-22 3     RTP801L3
HIF-1 Responsive Protein RTP801-Like2 3     

External Ids:    HGNC: 305551   Entrez Gene: 1152652   Ensembl: ENSG000001453587   OMIM: 6077305   UniProtKB: Q96D033   

Export aliases for DDIT4L gene to outside databases

Previous GC identifers: GC00U914340 GC04M101567 GC04M101464 GC04M101326 GC04M096845


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DDIT4L Gene:
DDIT4L (DNA-damage-inducible transcript 4-like) is a protein-coding gene. Diseases associated with DDIT4L include mature teratoma. An important paralog of this gene is DDIT4.

UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03
Function: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and
downstream of AKT1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDIT4L gene promoter:
         SRF   HOXA3   FOXF2   SREBP-1c   Brachyury   SRF (504 AA)   CUTL1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDIT4L promoter sequence
   Search Chromatin IP Primers for DDIT4L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDIT4L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q23

DDIT4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDIT4L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M101107:  view genomic region     (about GC identifiers)

Start:
101,107,027 bp from pter      End:
101,111,939 bp from pter
Size:
4,913 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03 (See protein sequence)
Recommended Name: DNA damage-inducible transcript 4-like protein  
Size: 193 amino acids; 21740 Da
Secondary accessions: B2R7C3

Explore the universe of human proteins at neXtProt for DDIT4L: NX_Q96D03

Explore proteomics data for DDIT4L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DDIT4L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_660287.1  
    ENSEMBL proteins: 
     ENSP00000354830   ENSP00000427301   ENSP00000427040  

    DDIT4L Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DDIT4L

     
    Search eBioscience for Proteins for DDIT4L 

     
    antibodies-online proteins for DDIT4L (8 products) 

     
    antibodies-online peptides for DDIT4L

    DDIT4L Antibody Products:

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    antibodies-online antibodies for DDIT4L (28 products) 

    DDIT4L Assay Products:

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    Cloud-Clone Corp. ELISAs for DDIT4L
    Cloud-Clone Corp. CLIAs for DDIT4L
    Search eBioscience for ELISAs for DDIT4L 
    antibodies-online kits for DDIT4L (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012918 RTP801-like

    Graphical View of Domain Structure for InterPro Entry Q96D03

    ProtoNet protein and cluster: Q96D03

    1 Blocks protein domain: IPB012918 RTP801

    UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03
    Similarity: Belongs to the DDIT4 family


    Find genes that share domains with DDIT4L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDT4L_HUMAN, Q96D03
    Function: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and
    downstream of AKT1
    Induction: Up-regulated by oxidized LDL and hypoxia in macrophages

    Phenotypes:
         1 GenomeRNAi human phenotype for DDIT4L:

     Increased HPV18 LCR reporter a 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DDIT4L

    miRNA
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    Block miRNA regulation of human, mouse, rat DDIT4L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDIT4L (see all 11):
    hsa-miR-21* hsa-miR-607 hsa-miR-429 hsa-miR-1283 hsa-miR-200a hsa-miR-141 hsa-miR-200c hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidDDIT4L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDIT4L
    Predesigned siRNA for gene silencing in human, mouse, rat DDIT4L

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for DDIT4L (see all 7)
    OriGene ORF clones in mouse, rat for DDIT4L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDIT4L (NM_145244)
    Sino Biological Human cDNA Clone for DDIT4L
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDIT4L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDIT4L

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDT4L_HUMAN, Q96D03: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ISS--

    Find genes that share ontologies with DDIT4L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDIT4L About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor signalling cascade
    TOR signaling0.32


    1 BioSystems Pathway for DDIT4L
        TOR signaling



        Pathway & Disease-focused RT2 Profiler PCR Arrays including DDIT4L: 
              mTOR Signaling in human mouse rat
              Hepatotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DDIT4L

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for DDIT4L (Q96D032, 3 ENSP000003548304) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNRPGP623083, ENSP000002723484I2D: score=3 STRING: ENSP00000272348
    PRKAB2ENSP000002541014STRING: ENSP00000254101
    --Q49AN93, 2MINT-66235 I2D: score=1 
    --Q49AN93, 2MINT-66235 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009968negative regulation of signal transduction IEA--

    Find genes that share ontologies with DDIT4L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDIT4L (DDT4L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDIT4L gene: 
    NM_145244.3  

    Unigene Cluster for DDIT4L:

    DNA-damage-inducible transcript 4-like
    Hs.480378  [show with all ESTs]
    Unigene Representative Sequence: NM_145244
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273990(uc003hvq.3) ENST00000502763 ENST00000513992
    miRNA
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    Block miRNA regulation of human, mouse, rat DDIT4L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDIT4L (see all 11):
    hsa-miR-21* hsa-miR-607 hsa-miR-429 hsa-miR-1283 hsa-miR-200a hsa-miR-141 hsa-miR-200c hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidDDIT4L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDIT4L
    Predesigned siRNA for gene silencing in human, mouse, rat DDIT4L
    Clone
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    GenScript: all cDNA clones in your preferred vector: DDIT4L (NM_145244)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDIT4L
    Primer
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    OriGene qPCR primer pairs and template standards for DDIT4L
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDIT4L
      QuantiTect SYBR Green Assays in human, mouse, rat DDIT4L
      QuantiFast Probe-based Assays in human, mouse, rat DDIT4L

    Additional mRNA sequence: 

    AK094236.1 AK312926.1 AL832277.1 BC013592.2 

    3 DOTS entries:

    DT.97803632  DT.95359179  DT.100665431 

    Selected AceView cDNA sequences (see all 69):

    BX417608 BF971140 AI624952 AK094236 Z43131 CB305849 BE613690 CF890855 
    BE886599 BU552568 BQ432373 BQ438284 BU175883 CD359119 BM463587 BF969068 
    AI375677 AL832277 AI624970 AI670890 BG772313 Z39216 BM470629 BE889624 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDIT4L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGTAGAAC
    DDIT4L Expression
    About this image


    DDIT4L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Growth Plate
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Mesoderm (Gastrulation Derivatives)
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Neural Tube (Nervous System)
             Diencephalic Ventricular Zone
    DDIT4L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDIT4L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480378

    UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03
    Tissue specificity: Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DDIT4L: 
              mTOR Signaling in human mouse rat
              Hepatotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDIT4L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DDIT4L gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddit4l1 , 5 DNA-damage-inducible transcript 4-like1, 5 89.88(n)1
    93.72(a)1
      3 (63.81 cM)5
    732841  NM_030143.41  NP_084419.21 
     1376216125 
    lizard
    (Anolis carolinensis)
    Reptilia DDIT4L6
    DNA-damage-inducible transcript 4-like
    71(a)
    1 ↔ 1
    GL343323.1(951527-959160)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ddit4l1 DNA-damage-inducible transcript 4-like 55.73(n)
    49.62(a)
      101733493  XM_004911448.1  XP_004911505.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta chrb6
    scyl6
    scylla
    17(a)
    16(a)
    many ↔ many
    many ↔ many
    3L(11480650-11492212)
    3L(11245410-11248343)


    ENSEMBL Gene Tree for DDIT4L (if available)
    TreeFam Gene Tree for DDIT4L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDIT4L gene
    DDIT42  
    1 SIMAP similar gene for DDIT4L using alignment to 3 protein entries:     DDT4L_HUMAN (see all proteins):
    DDIT4

    Find genes that share paralogs with DDIT4L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDIT4L (see all 155)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1851461081,2
    --101106696(+) TGCCTC/TCATTT 1 -- int10--------
    rs1483638261,2
    --101106728(+) GGAACA/GCAGCA 1 -- int10--------
    rs1156612661,2
    F--101106932(+) TATAAT/CGAGCC 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1899029621,2
    C--101106988(+) ACTGCA/GTCAAG 1 -- int10--------
    rs38191911,2
    C,F--101106989(-) ACTTGA/GTGCAG 1 -- int18Minor allele frequency- G:0.15NA WA CSA EA 367
    rs10532271,2
    C,F,O,H--101107168(-) CTTTTT/CCCACT 1 -- ut31 ese3 trp330Minor allele frequency- C:0.47MN NA EA NS WA CSA 3168
    rs10532251,2
    C,F--101107191(-) GGCATG/CGATGT 1 -- ut3113Minor allele frequency- C:0.49MN NA WA CSA EA 694
    rs38191881,2
    C,F--101107270(-) CTATTA/GTTAAG 1 -- ut31 ese30--------
    rs10638211,2
    C,F,A,H--101107276(-) GCATGT/GCTATT 1 -- ut31 ese327Minor allele frequency- G:0.45MN NS EA NA WA CSA 2846
    rs1177175561,2
    F--101107289(+) AACAAC/AATAGA 1 -- ut311Minor allele frequency- A:0.03EA 120

    HapMap Linkage Disequilibrium report for DDIT4L (101107027 - 101111939 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDIT4L:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830019CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DDIT4L
    DNA2.0 Custom Variant and Variant Library Synthesis for DDIT4L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607730    OMIM disorders: --

    1 disease for DDIT4L:    
    About MalaCards
    mature teratoma

    1 disease from the University of Copenhagen DISEASES database for DDIT4L:
    Mature teratoma

    Find genes that share disorders with DDIT4L           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: DDIT4L (1 document)

    Export disorders for DDIT4L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDIT4L gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DDIT4L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. (PubMed id 15308555)1, 2, 9 Cuaz-Perolin C.... Rouis M. (Arterioscler. Thromb. Vasc. Biol. 2004)
    2. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PubMed id 15632201)1, 2, 9 Corradetti M.N.... Guan K.-L. (J. Biol. Chem. 2005)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. (PubMed id 12453409)1, 2 Ellisen L.W.... Haber D.A. (Mol. Cell 2002)
    6. Two-hybrid analysis identifies PSMD11, a non-ATPase subunit of the proteasome, as a novel interaction partner of AMP-activated protein kinase. (PubMed id 19616115)1 Moreno D.... Sanz P. (Int. J. Biochem. Cell Biol. 2009)
    7. Genome-wide screen of promoter methylation identifies novel markers in melanoma. (PubMed id 19491193)1 Koga Y....Weissman S.M. (Genome Res. 2009)
    8. The regulated in development and DNA damage response 2 (REDD2) gene mediates human monocyte cell death through a reduction in thioredoxin-1 expression. (PubMed id 19268525)1 Imen J.S....Rouis M. (amp 2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115265 HGNC: 30555 AceView: DDIT4L Ensembl:ENSG00000145358 euGenes: HUgn115265
    ECgene: DDIT4L H-InvDB: DDIT4L

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDIT4L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDIT4L gene:
    Search GeneIP for patents involving DDIT4L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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