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Aliases for DDIT4L Gene

Aliases for DDIT4L Gene

  • DNA Damage Inducible Transcript 4 Like 2 3 5
  • Protein Regulated In Development And DNA Damage Response 2 3 4
  • Regulated In Development And DNA Damage Response 2 2 3
  • DNA-Damage-Inducible Transcript 4-Like 2 3
  • HIF-1 Responsive Protein RTP801-Like 3 4
  • Rtp801L 3 4
  • REDD-2 3 4
  • REDD2 3 4
  • Similar To Smhs1 Protein 2
  • Homolog Of Mouse SMHS1 3

External Ids for DDIT4L Gene

Previous GeneCards Identifiers for DDIT4L Gene

  • GC00U914340
  • GC04M101567
  • GC04M101464
  • GC04M101326
  • GC04M101107
  • GC04M096845

Summaries for DDIT4L Gene

GeneCards Summary for DDIT4L Gene

DDIT4L (DNA Damage Inducible Transcript 4 Like) is a Protein Coding gene. Among its related pathways are mTOR signalling. An important paralog of this gene is DDIT4.

UniProtKB/Swiss-Prot for DDIT4L Gene

  • Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDIT4L Gene

Genomics for DDIT4L Gene

Regulatory Elements for DDIT4L Gene

Enhancers for DDIT4L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDIT4L on UCSC Golden Path with GeneCards custom track

Promoters for DDIT4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDIT4L on UCSC Golden Path with GeneCards custom track

Genomic Location for DDIT4L Gene

100,185,110 bp from pter
100,190,782 bp from pter
5,673 bases
Minus strand

Genomic View for DDIT4L Gene

Genes around DDIT4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDIT4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDIT4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDIT4L Gene

Proteins for DDIT4L Gene

  • Protein details for DDIT4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA damage-inducible transcript 4-like protein
    Protein Accession:
    Secondary Accessions:
    • B2R7C3

    Protein attributes for DDIT4L Gene

    193 amino acids
    Molecular mass:
    21740 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDIT4L Gene

Proteomics data for DDIT4L Gene at MOPED

Post-translational modifications for DDIT4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDIT4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDIT4L Gene

Domains & Families for DDIT4L Gene

Protein Domains for DDIT4L Gene


Suggested Antigen Peptide Sequences for DDIT4L Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DDIT4 family.
  • Belongs to the DDIT4 family.
genes like me logo Genes that share domains with DDIT4L: view

No data available for Gene Families for DDIT4L Gene

Function for DDIT4L Gene

Molecular function for DDIT4L Gene

UniProtKB/Swiss-Prot Function:
Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
UniProtKB/Swiss-Prot Induction:
Up-regulated by oxidized LDL and hypoxia in macrophages.

Phenotypes for DDIT4L Gene

genes like me logo Genes that share phenotypes with DDIT4L: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDIT4L Gene

Localization for DDIT4L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDIT4L Gene


Subcellular locations from

Jensen Localization Image for DDIT4L Gene COMPARTMENTS Subcellular localization image for DDIT4L gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for DDIT4L Gene

Pathways & Interactions for DDIT4L Gene

SuperPathways for DDIT4L Gene

Superpath Contained pathways
1 mTOR signalling
genes like me logo Genes that share pathways with DDIT4L: view

Pathways by source for DDIT4L Gene

1 GeneTex pathway for DDIT4L Gene
1 BioSystems pathway for DDIT4L Gene

Gene Ontology (GO) - Biological Process for DDIT4L Gene


No data available for SIGNOR curated interactions for DDIT4L Gene

Drugs & Compounds for DDIT4L Gene

No Compound Related Data Available

Transcripts for DDIT4L Gene

mRNA/cDNA for DDIT4L Gene

Unigene Clusters for DDIT4L Gene

DNA-damage-inducible transcript 4-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDIT4L Gene

No ASD Table

Relevant External Links for DDIT4L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDIT4L Gene

mRNA expression in normal human tissues for DDIT4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDIT4L Gene

This gene is overexpressed in Muscle - Skeletal (x33.1).

Protein differential expression in normal tissues from HIPED for DDIT4L Gene

This gene is overexpressed in Kidney (40.6), Heart (22.3), and Bone marrow mesenchymal stem cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DDIT4L Gene

SOURCE GeneReport for Unigene cluster for DDIT4L Gene Hs.480378

mRNA Expression by UniProt/SwissProt for DDIT4L Gene

Tissue specificity: Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery.
genes like me logo Genes that share expression patterns with DDIT4L: view

Protein tissue co-expression partners for DDIT4L Gene

Primer Products

Orthologs for DDIT4L Gene

This gene was present in the common ancestor of animals.

Orthologs for DDIT4L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDIT4L 35
  • 90.4 (n)
  • 94.24 (a)
  • 93 (a)
(Canis familiaris)
Mammalia DDIT4L 35
  • 90.58 (n)
  • 94.24 (a)
  • 71 (a)
(Mus musculus)
Mammalia Ddit4l 35
  • 89.88 (n)
  • 93.72 (a)
Ddit4l 16
Ddit4l 36
  • 93 (a)
(Pan troglodytes)
Mammalia DDIT4L 35
  • 99.31 (n)
  • 99.48 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC100363484 35
  • 88.13 (n)
  • 93.72 (a)
(Monodelphis domestica)
Mammalia DDIT4L 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia DDIT4L 36
  • 66 (a)
(Anolis carolinensis)
Reptilia DDIT4L 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddit4l 35
  • 55.73 (n)
  • 49.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta chrb 36
  • 17 (a)
scyl 36
  • 16 (a)
Species with no ortholog for DDIT4L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DDIT4L Gene

Gene Tree for DDIT4L (if available)
Gene Tree for DDIT4L (if available)

Paralogs for DDIT4L Gene

Paralogs for DDIT4L Gene

(1) SIMAP similar genes for DDIT4L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDIT4L: view

Variants for DDIT4L Gene

Sequence variations from dbSNP and Humsavar for DDIT4L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11553154 - 100,187,777(-) CTTCT(C/T)CTCTG reference, missense
rs957239 -- 100,185,209(+) TCCTA(A/G)AATCT utr-variant-3-prime
rs1053225 -- 100,186,034(-) GGCAT(C/G)GATGT utr-variant-3-prime
rs1053227 -- 100,186,011(-) CTTTT(C/T)CCACT utr-variant-3-prime
rs1063821 -- 100,186,119(-) GCATG(G/T)CTATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDIT4L Gene

Variant ID Type Subtype PubMed ID
nsv830019 CNV Gain 17160897

Variation tolerance for DDIT4L Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDIT4L Gene

Disorders for DDIT4L Gene

Relevant External Links for DDIT4L

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDIT4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDIT4L Gene

Publications for DDIT4L Gene

  1. REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. (PMID: 15308555) Cuaz-Perolin C. … Rouis M. (Arterioscler. Thromb. Vasc. Biol. 2004) 3 4 23 67
  2. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PMID: 15632201) Corradetti M.N. … Guan K.-L. (J. Biol. Chem. 2005) 3 23
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for DDIT4L Gene

Sources for DDIT4L Gene