DDIT4L Gene
protein-coding GIFtS : 52
GCID: GC04 M101107
DNA-damage-inducible transcript 4-like
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Aliasesfor DDIT4L gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases DNA-Damage-Inducible Transcript 4-Like 1 2 HIF-1 Responsive Protein RTP801-Like2 3 REDD21 2 3 5 DNA Damage-Inducible Transcript 4-Like Protein2 Rtp801L1 2 Homolog Of Mouse SMHS12 Protein Regulated In Development And DNA Damage Response 22 3 Regulated In Development And DNA Damage Response 22 REDD-22 3 RTP801L3
Export aliases for DDIT4L gene to outside databases Previous GC identifers: GC00U914340 GC04M101567 GC04M101464 GC04M101326 GC04M096845
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Summariesfor DDIT4L gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03 Function : Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstreamof AKT1
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Genomic Viewsfor DDIT4L gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000004.11 NC_018915.1 NT_016354.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DDIT4L gene promoter: SRF HOXA3 FOXF2 SREBP-1c Brachyury SRF (504 AA) CUTL1 C/EBPalpha Other transcription factors Search SABiosciences Chromatin IP Primers for DDIT4L Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DDIT4L
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q23 DDIT4L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M101107: view genomic region
(about GC identifiers )
Start:
101,107,027 bp from pter
End:
101,111,939 bp from pter
Size:
4,913 bases
Orientation:
minus strand
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Proteinsfor DDIT4L gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03 (See
protein sequence )Recommended Name: DNA damage-inducible transcript 4-like protein Size : 193 amino acids; 21740 Da
Subcellular location : Cytoplasm (By similarity)
Secondary accessions : B2R7C3Explore the universe of human proteins at neXtProt for DDIT4L: NX_Q96D03 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96D03 DDIT4L Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_660287.1 ENSEMBL proteins: ENSP00000354830 ENSP00000427301 ENSP00000427040 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
ISS --
DDIT4L for ontologies About GeneDecksing DDIT4L Antibody Products: Assay Products for DDIT4L:
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Protein
Domains / Familiesfor DDIT4L gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DDIT4L for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q96D03 ProtoNet protein and cluster: Q96D03
1 Blocks protein family : IPB012918 RTP801 UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03 Similarity : Belongs to the DDIT4 family
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Functionfor DDIT4L gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03 Function : Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstreamof AKT1 Induction : Up-regulated by oxidized LDL and hypoxia in macrophages
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDIT4L (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDIT4L (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DDIT4L (NM_145244 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDIT4L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDIT4L
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4L
1 GenomeRNAi human phenotype for DDIT4L :
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Pathways & Interactionsfor DDIT4L gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 mTOR signalling
1 BioSystems Pathway for DDIT4L Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDIT4L STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)4 Interacting proteins for DDIT4L (Q96D03 2 , 3 ENSP00000354830 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0009968 negative regulation of signal transduction
IEA --
DDIT4L for ontologies About GeneDecksing
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Drugs & Compoundsfor DDIT4L gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DDIT4L Search CenterWatch for drugs/clinical trials and news about DDIT4L / DDT4L
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Transcriptsfor DDIT4L gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DDIT4L gene: NM_145244.3 Unigene Cluster for DDIT4L:
DNA-damage-inducible transcript 4-like Hs.480378 [show with all ESTs ] Unigene Representative Sequence: NM_145244 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000273990 (uc003hvq.3 ) ENST00000502763 ENST00000513992 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDIT4L (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDIT4L (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DDIT4L (NM_145244 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDIT4L Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDIT4L
Additional cDNA sequence: AK094236.1 AK312926.1 AL832277.1 BC013592.2
3 DOTS entries : DT.97803632 DT.95359179
DT.100665431 24/69 AceView cDNA sequences (see all 69 ):
BE613690 CB305849 BE886599 AI624952 AK094236 BF971140 BQ432373 Z43131 BX417608 BU552568 CF890855 BQ015667 BE889624 AA528140 BX451396 BM800486 AI670890 BQ438284 BM463587 BG428930 BE613468 NM_145244 BM800359 BQ231185 GeneLoc Exon Structure
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Expression for DDIT4L gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DDIT4L expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GATGTAGAAC
About this image DDIT4L expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See DDIT4L Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DDIT4L SOURCE GeneReport for Unigene cluster: Hs.480378 UniProtKB/Swiss-Prot: DDT4L_HUMAN, Q96D03 Tissue specificity : Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery SABiosciences Expression via Pathway-Focused PCR Arrays including DDIT4L : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DDIT4LBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DDIT4L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DDIT4L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DDIT4L In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4L
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Orthologsfor DDIT4L gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for DDIT4L gene from 2/12 species (see all 12 ) About this table
ENSEMBL Gene Tree for DDIT4L (if available)TreeFam Gene Tree for DDIT4L (if available)
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Paralogsfor DDIT4L gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DDIT4L gene DDIT4 2 1 SIMAP similar gene for DDIT4L using alignment to 3 protein entries: DDT4L_HUMAN (see all proteins ):DDIT4
DDIT4L for paralogs About GeneDecksing
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Genomic Variantsfor DDIT4L gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor DDIT4L gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DDIT4L for disorders About GeneDecksing
OMIM gene information: 607730
OMIM disorders : --4 diseases for DDIT4L : About MalaCards mature teratoma teratoma hypoxia melanoma 1 disease from the University of Copenhagen DISEASES database for DDIT4L :Mature teratoma Human Genome Epidemiology (HuGE) Navigator: DDIT4L (1 document)Export disorders for DDIT4L gene to outside databases
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Publicationsfor DDIT4L gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DDIT4L gene, integrated from 9 sources (see all 14 ): (articles sorted by number of sources associating them with DDIT4L) Utopia : connect your pdf to the dynamic world of online information
REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. (PubMed id 15308555) 1 , 2 , 9 Cuaz-Perolin C.... Rouis M. (2004) The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PubMed id 15632201) 1 , 2 , 9 Corradetti M.N.... Guan K.-L. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. (PubMed id 12453409) 1 , 2 Ellisen L.W.... Haber D.A. (2002) Two-hybrid analysis identifies PSMD11, a non-ATPase s ubunit of the proteasome, as a novel interaction partner of AMP-activated prote in kinase. (PubMed id 19616115) 1 Moreno D....Sanz P. (2009) Genome-wide screen of promoter methylation identifies novel markers in melanoma. (PubMed id 19491193) 1 Koga Y....Weissman S.M. (2009) The regulated in development and DNA damage response 2 (REDD2) gene mediates human monocyte cell death through a reduction in thiore doxin-1 expression. (PubMed id 19268525) 1 Imen J.S....Rouis M. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007)
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External Searches for DDIT4L gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DDIT4L gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DDIT4L gene
(According to HUGE )
About This Section --
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Specialized Databases showing DDIT4L gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DDIT4L Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DDIT4L gene: Search GeneIP for patents involving DDIT4L GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DDIT4L gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DDIT4L OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DDIT4L OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DDIT4L Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DDIT4L OriGene 3'-UTR Clone for DDIT4L OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DDIT4L OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DDIT4L Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DDIT4L OriGene Custom Protein Services for DDIT4L OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDIT4L Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDIT4L QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DDIT4L QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DDIT4L QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DDIT4L QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DDIT4L
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DDIT4L Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4L
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DDIT4L
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