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Aliases for DDIT4L Gene

Aliases for DDIT4L Gene

  • DNA-Damage-Inducible Transcript 4-Like 2 3
  • REDD2 3 4 6
  • Protein Regulated In Development And DNA Damage Response 2 3 4
  • Regulated In Development And DNA Damage Response 2 2 3
  • HIF-1 Responsive Protein RTP801-Like 3 4
  • Rtp801L 3 4
  • REDD-2 3 4
  • DNA Damage-Inducible Transcript 4-Like Protein 3
  • Similar To Smhs1 Protein 2
  • Homolog Of Mouse SMHS1 3

External Ids for DDIT4L Gene

Previous GeneCards Identifiers for DDIT4L Gene

  • GC00U914340
  • GC04M101567
  • GC04M101464
  • GC04M101326
  • GC04M101107
  • GC04M096845

Summaries for DDIT4L Gene

GeneCards Summary for DDIT4L Gene

DDIT4L (DNA-Damage-Inducible Transcript 4-Like) is a Protein Coding gene. Diseases associated with DDIT4L include mature teratoma. Among its related pathways are Insulin receptor signalling cascade. An important paralog of this gene is DDIT4.

UniProtKB/Swiss-Prot for DDIT4L Gene

  • Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDIT4L Gene

Genomics for DDIT4L Gene

Regulatory Elements for DDIT4L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDIT4L Gene

100,185,110 bp from pter
100,190,782 bp from pter
5,673 bases
Minus strand

Genomic View for DDIT4L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDIT4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDIT4L Gene

Proteins for DDIT4L Gene

  • Protein details for DDIT4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA damage-inducible transcript 4-like protein
    Protein Accession:
    Secondary Accessions:
    • B2R7C3

    Protein attributes for DDIT4L Gene

    193 amino acids
    Molecular mass:
    21740 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDIT4L Gene

Proteomics data for DDIT4L Gene at MOPED

Post-translational modifications for DDIT4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDIT4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDIT4L Gene

Domains for DDIT4L Gene

Protein Domains for DDIT4L Gene


Suggested Antigen Peptide Sequences for DDIT4L Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96D03
  • Belongs to the DDIT4 family.
genes like me logo Genes that share domains with DDIT4L: view

No data available for Gene Families for DDIT4L Gene

Function for DDIT4L Gene

Molecular function for DDIT4L Gene

UniProtKB/Swiss-Prot Function: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1.
UniProtKB/Swiss-Prot Induction: Up-regulated by oxidized LDL and hypoxia in macrophages.

Gene Ontology (GO) - Molecular Function for DDIT4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DDIT4L: view

Phenotypes for DDIT4L Gene

GenomeRNAi human phenotypes for DDIT4L:
genes like me logo Genes that share phenotypes with DDIT4L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DDIT4L Gene

Localization for DDIT4L Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDIT4L Gene


Subcellular locations from

Jensen Localization Image for DDIT4L Gene COMPARTMENTS Subcellular localization image for DDIT4L gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DDIT4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with DDIT4L: view

Pathways for DDIT4L Gene

SuperPathways for DDIT4L Gene

Superpath Contained pathways
1 Insulin receptor signalling cascade
genes like me logo Genes that share pathways with DDIT4L: view

Pathways by source for DDIT4L Gene

1 BioSystems pathway for DDIT4L Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for DDIT4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009968 negative regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with DDIT4L: view

Transcripts for DDIT4L Gene

mRNA/cDNA for DDIT4L Gene

Unigene Clusters for DDIT4L Gene

DNA-damage-inducible transcript 4-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDIT4L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDIT4L Gene

No ASD Table

Relevant External Links for DDIT4L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDIT4L Gene

mRNA expression in normal human tissues for DDIT4L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DDIT4L Gene

This gene is overexpressed in Muscle - Skeletal (33.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DDIT4L Gene

SOURCE GeneReport for Unigene cluster for DDIT4L Gene Hs.480378

mRNA Expression by UniProt/SwissProt for DDIT4L Gene

Tissue specificity: Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery.
genes like me logo Genes that share expressions with DDIT4L: view

In Situ Assay Products

Orthologs for DDIT4L Gene

This gene was present in the common ancestor of animals.

Orthologs for DDIT4L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDIT4L 35
  • 99.31 (n)
  • 99.48 (a)
  • 99 (a)
(Bos Taurus)
Mammalia DDIT4L 35
  • 90.4 (n)
  • 94.24 (a)
  • 93 (a)
(Canis familiaris)
Mammalia DDIT4L 35
  • 90.58 (n)
  • 94.24 (a)
  • 71 (a)
(Mus musculus)
Mammalia Ddit4l 35
  • 89.88 (n)
  • 93.72 (a)
Ddit4l 16
Ddit4l 36
  • 93 (a)
(Monodelphis domestica)
Mammalia DDIT4L 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia DDIT4L 36
  • 66 (a)
(Rattus norvegicus)
Mammalia LOC100363484 35
  • 88.13 (n)
  • 93.72 (a)
(Anolis carolinensis)
Reptilia DDIT4L 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddit4l 35
  • 55.73 (n)
  • 49.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta chrb 36
  • 17 (a)
scyl 36
  • 16 (a)
Species with no ortholog for DDIT4L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DDIT4L Gene

Gene Tree for DDIT4L (if available)
Gene Tree for DDIT4L (if available)

Paralogs for DDIT4L Gene

Paralogs for DDIT4L Gene

Selected SIMAP similar genes for DDIT4L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDIT4L: view

Variants for DDIT4L Gene

Sequence variations from dbSNP and Humsavar for DDIT4L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs957239 -- 100,185,209(+) TCCTA(A/G)AATCT utr-variant-3-prime
rs1053225 -- 100,186,034(-) GGCAT(C/G)GATGT utr-variant-3-prime
rs1053227 -- 100,186,011(-) CTTTT(C/T)CCACT utr-variant-3-prime
rs1063821 -- 100,186,119(-) GCATG(G/T)CTATT utr-variant-3-prime
rs2866196 -- 100,184,954(+) taata(C/T)agcct downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DDIT4L Gene

Variant ID Type Subtype PubMed ID
nsv830019 CNV Gain 17160897

Relevant External Links for DDIT4L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDIT4L Gene

Disorders for DDIT4L Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DDIT4L Gene including...

Search for DDIT4L Gene in MalaCards »

(1) University of Copenhagen DISEASES for DDIT4L Gene

Relevant External Links for DDIT4L

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DDIT4L: view

No data available for UniProtKB/Swiss-Prot for DDIT4L Gene

Publications for DDIT4L Gene

  1. REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death. (PMID: 15308555) Cuaz-Perolin C. … Rouis M. (Arterioscler. Thromb. Vasc. Biol. 2004) 3 4 23
  2. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PMID: 15632201) Corradetti M.N. … Guan K.-L. (J. Biol. Chem. 2005) 3 4 23
  3. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. (PMID: 12453409) Ellisen L.W. … Haber D.A. (Mol. Cell 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for DDIT4L Gene

Sources for DDIT4L Gene

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