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Aliases for DDIT4 Gene

Aliases for DDIT4 Gene

  • DNA-Damage-Inducible Transcript 4 2 3
  • REDD1 3 4 6
  • Protein Regulated In Development And DNA Damage Response 1 3 4
  • HIF-1 Responsive Protein RTP801 3 4
  • REDD-1 3 4
  • RTP801 4 6
  • DNA Damage-Inducible Transcript 4 Protein 3
  • HIF-1 Responsive RTP801 2
  • Dig2 3

External Ids for DDIT4 Gene

Previous GeneCards Identifiers for DDIT4 Gene

  • GC00U914339
  • GC10P073379
  • GC10P073703
  • GC10P074033
  • GC10P068028

Summaries for DDIT4 Gene

GeneCards Summary for DDIT4 Gene

DDIT4 (DNA-Damage-Inducible Transcript 4) is a Protein Coding gene. Diseases associated with DDIT4 include renal cell carcinoma. Among its related pathways are PI3K-Akt signaling pathway and p70S6K Signaling. GO annotations related to this gene include 14-3-3 protein binding. An important paralog of this gene is DDIT4L.

UniProtKB/Swiss-Prot for DDIT4 Gene

  • Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.

Gene Wiki entry for DDIT4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDIT4 Gene

Genomics for DDIT4 Gene

Regulatory Elements for DDIT4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDIT4 Gene

Start:
72,273,919 bp from pter
End:
72,276,039 bp from pter
Size:
2,121 bases
Orientation:
Plus strand

Genomic View for DDIT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDIT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDIT4 Gene

Proteins for DDIT4 Gene

  • Protein details for DDIT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX09-DDIT4_HUMAN
    Recommended name:
    DNA damage-inducible transcript 4 protein
    Protein Accession:
    Q9NX09
    Secondary Accessions:
    • Q9H0S3

    Protein attributes for DDIT4 Gene

    Size:
    232 amino acids
    Molecular mass:
    25371 Da
    Quaternary structure:
    • Monomer. Interacts with BTRC. Identified in a complex with CUL4A, DDB1 and BTRC. Interacts with TXNIP; this inhibits the proteasomal degradation of DDIT4.

    Three dimensional structures from OCA and Proteopedia for DDIT4 Gene

neXtProt entry for DDIT4 Gene

Proteomics data for DDIT4 Gene at MOPED

Post-translational modifications for DDIT4 Gene

  • Phosphorylated by GSK3B; this promotes proteasomal degradation.
  • Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as substrate-recognition component, leading to its proteasomal degradation.
  • Ubiquitination at Lys129, Lys188, and Lys220
  • Modification sites at PhosphoSitePlus

Other Protein References for DDIT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DDIT4 (DDIT4)

No data available for DME Specific Peptides for DDIT4 Gene

Domains for DDIT4 Gene

Protein Domains for DDIT4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DDIT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NX09

UniProtKB/Swiss-Prot:

DDIT4_HUMAN :
  • Q9NX09
Family:
  • Belongs to the DDIT4 family.
genes like me logo Genes that share domains with DDIT4: view

No data available for Gene Families for DDIT4 Gene

Function for DDIT4 Gene

Molecular function for DDIT4 Gene

UniProtKB/Swiss-Prot Function: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.
UniProtKB/Swiss-Prot Induction: Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism (at protein level).

Gene Ontology (GO) - Molecular Function for DDIT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071889 14-3-3 protein binding IEA --
genes like me logo Genes that share ontologies with DDIT4: view
genes like me logo Genes that share phenotypes with DDIT4: view

Animal Models for DDIT4 Gene

MGI Knock Outs for DDIT4:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDIT4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DDIT4 Gene

Localization for DDIT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDIT4 Gene

Mitochondrion. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDIT4 Gene COMPARTMENTS Subcellular localization image for DDIT4 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DDIT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DDIT4: view

Pathways for DDIT4 Gene

genes like me logo Genes that share pathways with DDIT4: view

Pathways by source for DDIT4 Gene

1 Qiagen pathway for DDIT4 Gene
2 Cell Signaling Technology pathways for DDIT4 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DDIT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 20166753
GO:0001764 neuron migration ISS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007420 brain development ISS --
GO:0008283 cell proliferation ISS --
genes like me logo Genes that share ontologies with DDIT4: view

Transcripts for DDIT4 Gene

mRNA/cDNA for DDIT4 Gene

Unigene Clusters for DDIT4 Gene

DNA-damage-inducible transcript 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDIT4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDIT4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for DDIT4 Gene

GeneLoc Exon Structure for
DDIT4
ECgene alternative splicing isoforms for
DDIT4

Expression for DDIT4 Gene

mRNA expression in normal human tissues for DDIT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DDIT4 Gene

SOURCE GeneReport for Unigene cluster for DDIT4 Gene Hs.744875

mRNA Expression by UniProt/SwissProt for DDIT4 Gene

Q9NX09-DDIT4_HUMAN
Tissue specificity: Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level).
genes like me logo Genes that share expressions with DDIT4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DDIT4 Gene

Orthologs for DDIT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDIT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDIT4 35
  • 99.43 (n)
  • 99.57 (a)
DDIT4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDIT4 35
  • 90.68 (n)
  • 94.32 (a)
DDIT4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDIT4 35
  • 93.19 (n)
  • 94.35 (a)
DDIT4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddit4 35
  • 87.34 (n)
  • 92.14 (a)
Ddit4 16
Ddit4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDIT4 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDIT4 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddit4 35
  • 87.34 (n)
  • 91.7 (a)
lizard
(Anolis carolinensis)
Reptilia DDIT4 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64453 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ddit4 35
  • 60.11 (n)
  • 62.84 (a)
MGC76013 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10950 35
zebrafish
(Danio rerio)
Actinopterygii ddit4 35
  • 57.63 (n)
  • 54.24 (a)
ddit4 36
  • 43 (a)
OneToOne
sbcb821 35
fruit fly
(Drosophila melanogaster)
Insecta chrb 36
  • 15 (a)
ManyToMany
scyl 36
  • 15 (a)
ManyToMany
Species with no ortholog for DDIT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDIT4 Gene

ENSEMBL:
Gene Tree for DDIT4 (if available)
TreeFam:
Gene Tree for DDIT4 (if available)

Paralogs for DDIT4 Gene

Paralogs for DDIT4 Gene

Selected SIMAP similar genes for DDIT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDIT4: view

Variants for DDIT4 Gene

Sequence variations from dbSNP and Humsavar for DDIT4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs8316 -- 72,275,539(+) CAGCC(C/T)GGCCC utr-variant-3-prime
rs11192 -- 72,275,958(-) TCATG(A/G)ACAGT utr-variant-3-prime
rs13618 -- 72,275,589(-) CCCCC(C/T)TCCCT utr-variant-3-prime
rs877767 -- 72,272,608(+) TCTAA(A/G)TTGGG upstream-variant-2KB
rs1053639 -- 72,275,283(+) ATTCC(A/T)GTGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DDIT4 Gene

Variant ID Type Subtype PubMed ID
nsv895721 CNV Gain 21882294

Relevant External Links for DDIT4 Gene

HapMap Linkage Disequilibrium report
DDIT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDIT4 Gene

Disorders for DDIT4 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DDIT4 Gene including...

Search for DDIT4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DDIT4 Gene

Relevant External Links for DDIT4

Genetic Association Database (GAD)
DDIT4
Human Genome Epidemiology (HuGE) Navigator
DDIT4
genes like me logo Genes that share disorders with DDIT4: view

No data available for UniProtKB/Swiss-Prot for DDIT4 Gene

Publications for DDIT4 Gene

  1. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PMID: 15632201) Corradetti M.N. … Guan K.-L. (J. Biol. Chem. 2005) 3 4 23
  2. Regulation of mTOR and cell growth in response to energy stress by REDD1. (PMID: 15988001) Sofer A. … Ellisen L.W. (Mol. Cell. Biol. 2005) 3 4 23
  3. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. (PMID: 11884613) Shoshani T. … Feinstein E. (Mol. Cell. Biol. 2002) 2 3 4
  4. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. (PMID: 12453409) Ellisen L.W. … Haber D.A. (Mol. Cell 2002) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for DDIT4 Gene

Sources for DDIT4 Gene

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