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DDIT4 Gene

protein-coding   GIFtS: 58
GCID: GC10P074033

DNA-Damage-Inducible Transcript 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DNA-Damage-Inducible Transcript 41 2     RTP8013 5
REDD12 3 5     HIF-1 Responsive RTP8011
Protein Regulated In Development And DNA Damage Response 12 3     Dig22
REDD-12 3     DNA Damage-Inducible Transcript 4 Protein2
HIF-1 Responsive Protein RTP8012 3     

External Ids:    HGNC: 249441   Entrez Gene: 545412   Ensembl: ENSG000001682097   OMIM: 6077295   UniProtKB: Q9NX093   

Export aliases for DDIT4 gene to outside databases

Previous GC identifers: GC00U914339 GC10P073379 GC10P073703 GC10P068028


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DDIT4 Gene:
DDIT4 (DNA-damage-inducible transcript 4) is a protein-coding gene. GO annotations related to this gene include 14-3-3 protein binding. An important paralog of this gene is DDIT4L.

UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
Function: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target
of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1,
the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and
cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response
to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it
mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for
mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal
differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal
neuron migration during embryonic brain development. Plays a role in neuronal cell death

Gene Wiki entry for DDIT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DDIT4 gene promoter:
         GR   FOXF2   p53   Brachyury   FOXD3   Nkx2-5   Arnt   MEF-2A   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDIT4 promoter sequence
   Search Chromatin IP Primers for DDIT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDIT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

DDIT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDIT4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P074033:  view genomic region     (about GC identifiers)

Start:
74,033,677 bp from pter      End:
74,035,797 bp from pter
Size:
2,121 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09 (See protein sequence)
Recommended Name: DNA damage-inducible transcript 4 protein  
Size: 232 amino acids; 25371 Da
Subunit: Monomer. Interacts with BTRC. Identified in a complex with CUL4A, DDB1 and BTRC. Interacts with TXNIP;
this inhibits the proteasomal degradation of DDIT4
1 PDB 3D structure from and Proteopedia for DDIT4:
3LQ9 (3D)    
Secondary accessions: Q9H0S3

Explore the universe of human proteins at neXtProt for DDIT4: NX_Q9NX09

Explore proteomics data for DDIT4 at MOPED

Post-translational modifications: 

  • Phosphorylated by GSK3B; this promotes proteasomal degradation1
  • Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as
    substrate-recognition component, leading to its proteasomal degradation1
  • Ubiquitination2 at Lys129, Lys188, Lys220
  • Modification sites at PhosphoSitePlus

  • See DDIT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061931.1  
    ENSEMBL proteins: 
     ENSP00000307305  

    DDIT4 Human Recombinant Protein Products:

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    Novus Biologicals DDIT4 Proteins
    Novus Biologicals DDIT4 Lysates
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    ProSpec Recombinant Protein for DDIT4
    Cloud-Clone Corp. Proteins for DDIT4

     
    Search eBioscience for Proteins for DDIT4 

     
    antibodies-online proteins for DDIT4 (14 products) 

     
    antibodies-online peptides for DDIT4

    DDIT4 Antibody Products:

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    antibodies-online antibodies for DDIT4 (66 products) 

    DDIT4 Assay Products:

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    antibodies-online kits for DDIT4 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012918 RTP801-like

    Graphical View of Domain Structure for InterPro Entry Q9NX09

    ProtoNet protein and cluster: Q9NX09

    1 Blocks protein domain: IPB012918 RTP801

    UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
    Similarity: Belongs to the DDIT4 family


    Find genes that share domains with DDIT4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDIT4_HUMAN, Q9NX09
    Function: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target
    of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1,
    the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and
    cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response
    to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it
    mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for
    mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal
    differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal
    neuron migration during embryonic brain development. Plays a role in neuronal cell death
    Induction: Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63
    in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA
    alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and
    HIF1A-dependent but TP53/TP63-independent mechanism (at protein level)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:007188914-3-3 protein binding IEA--
         
    Find genes that share ontologies with DDIT4           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ddit4):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  nervous system 
     reproductive system  vision/eye 

    Find genes that share phenotypes with DDIT4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ddit4tm1.1Sinc for DDIT4

       genOway: Develop your customized and physiologically relevant rodent model for DDIT4

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDIT4:
    hsa-mir-615-3p (MIRT040402), hsa-mir-124-3p (MIRT022661), hsa-mir-181a-5p (MIRT005575), hsa-mir-101-3p (MIRT027381), hsa-mir-221-3p (MIRT003358)

    Block miRNA regulation of human, mouse, rat DDIT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDIT4 (see all 65):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidDDIT4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDIT4
    Predesigned siRNA for gene silencing in human, mouse, rat DDIT4

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: DDIT4 (NM_019058)
    Sino Biological Human cDNA Clone for DDIT4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDIT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDIT4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DDIT4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12007) for DDIT4 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DDIT4_HUMAN, Q9NX09: Mitochondrion (By similarity). Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IDA12453409
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IEA--

    Find genes that share ontologies with DDIT4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DDIT4 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1p70S6K Signaling
    mTOR Pathway0.54
    2Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    3Insulin receptor signalling cascade
    TOR signaling0.32
    4Cell Cycle / Checkpoint Control
    DNA Damage0.32
    5PI3K / Akt Signaling
    PI3K / Akt Signaling


    Find genes that share SuperPaths with DDIT4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DDIT4
        mTOR Pathway

    2 Cell Signaling Technology (CST) Pathways for DDIT4
        PI3K / Akt Signaling
    DNA Damage

    3 BioSystems Pathways for DDIT4
        TOR signaling
    mTOR signaling pathway
    Direct p53 effectors



    3 Kegg Pathways  (Kegg details for DDIT4):
        mTOR signaling pathway
    PI3K-Akt signaling pathway
    MicroRNAs in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DDIT4: 
              mTOR Signaling in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DDIT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for DDIT4 (Q9NX092, 3 ENSP000003073054) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2972, 3, ENSP000003592064MINT-7255840 MINT-7255886 I2D: score=1 STRING: ENSP00000359206
    PDPK1O155302, 3, ENSP000003442204MINT-8265522 I2D: score=2 STRING: ENSP00000344220
    PLCG1P191742, 3, ENSP000002440074MINT-7255813 I2D: score=1 STRING: ENSP00000244007
    LRIF1Q5T3J32, 3MINT-65448 I2D: score=4 
    DDB1Q165312, 3, ENSP000003017644MINT-7255853 MINT-7255865 I2D: score=1 STRING: ENSP00000301764
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA--
    GO:0001764neuron migration ISS--
    GO:0007420brain development ISS--
    GO:0008283cell proliferation ISS--
    GO:0009968negative regulation of signal transduction ----

    Find genes that share ontologies with DDIT4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDIT4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDIT4 gene: 
    NM_019058.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307365(uc001jsx.1) ENST00000473155 ENST00000471240
    miRNA
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    Block miRNA regulation of human, mouse, rat DDIT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDIT4 (see all 65):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidDDIT4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DDIT4
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    GenScript: all cDNA clones in your preferred vector: DDIT4 (NM_019058)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDIT4
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      QuantiFast Probe-based Assays in human, mouse, rat DDIT4
    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-12007) for DDIT4 

    Selected AceView cDNA sequences (see all 902):

    CR591852 BX357889 CR619259 AW192865 CA395008 AI469090 BI092847 AW316834 
    AI765626 CA417513 BM854380 AI459590 AI984063 AA643059 AA429539 BI869888 
    CA844015 BQ939730 AI813922 CA426328 BM790825 CR622434 AW029181 CR601977 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DDIT4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:              -                     
    SP2:                                    
    SP3:        -     -                     
    SP4:              -                     


    ECgene alternative splicing isoforms for DDIT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDIT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTTAAAA
    DDIT4 Expression
    About this image


    DDIT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             pre Conventional Dendritic Cells Peripheral Blood
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Uterus (Reproductive System)
     
     Ovary (Reproductive System)
    DDIT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDIT4 Protein Expression

    UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
    Tissue specificity: Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in
    substantia nigra neurons from Parkinson disease patients (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DDIT4: 
              mTOR Signaling in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDIT4
    OriGene qSTAR qPCR primer pairs in human, mouse for DDIT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDIT4
    QuantiTect SYBR Green Assays in human, mouse, rat DDIT4
    QuantiFast Probe-based Assays in human, mouse, rat DDIT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DDIT4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddit41 , 5 DNA-damage-inducible transcript 41, 5 87.34(n)1
    92.14(a)1
      10 (29.66 cM)5
    747471  NM_029083.21  NP_083359.11 
     599496755 
    lizard
    (Anolis carolinensis)
    Reptilia DDIT46
    DNA-damage-inducible transcript 4
    71(a)
    1 ↔ 1
    3(51710509-51715418)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC644532 hypothetical protein MGC64453 73.26(n)    BC054246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb8212 sbcb821 73.33(n)   378866  BC053258.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta chrb6
    scyl6
    scylla
    15(a)
    15(a)
    many ↔ many
    many ↔ many
    3L(11480650-11492212)
    3L(11245410-11248343)


    ENSEMBL Gene Tree for DDIT4 (if available)
    TreeFam Gene Tree for DDIT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDIT4 gene
    DDIT4L2  
    1 SIMAP similar gene for DDIT4 using alignment to 1 protein entry:     DDIT4_HUMAN:
    DDIT4L

    Find genes that share paralogs with DDIT4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDIT4 (see all 122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs64806081,2
    C,F,A--74031694(+) ACCTGT/CAGTTC 1 -- us2k16Minor allele frequency- C:0.45NA WA CSA 11
    rs1848365421,2
    --74031748(+) GAGGCA/GGAGCT 1 -- us2k10--------
    rs1879814871,2
    --74031830(+) AAAAAA/GAAGAA 1 -- us2k10--------
    rs578196401,2
    C--74031832(+) AAAAAAA/-GAAGA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs2014721791,2
    C--74031833(-) TTCTTC/TTNNNN 1 -- us2k10--------
    rs2001219681,2
    C--74031851(+) AAAAA-/AC    
       ATCGT
    AACTC
    1 -- us2k10--------
    rs38344181,2
    C--74031942(+) GATCT-/TCTCTCTG 2 -- us2k1 cds10--------
    rs341652101,2
    C--74031942(+) TCAGA-/TCTTCTCT 1 -- us2k11Minor allele frequency- TCT:0.00NA 2
    rs2004117181,2
    --74031946(+) ATCTT-/CTCTCTGG 1 -- us2k10--------
    rs1464711331,2
    --74032116(+) TAAGGC/TTCCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDIT4 (74033677 - 74035797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDIT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895721CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDIT4
    DNA2.0 Custom Variant and Variant Library Synthesis for DDIT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607729    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DDIT4:
    Tuberous sclerosis

    Find genes that share disorders with DDIT4           About GenesLikeMe

    Genetic Association Database (GAD): DDIT4
    Human Genome Epidemiology (HuGE) Navigator: DDIT4 (1 document)

    Export disorders for DDIT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDIT4 gene, integrated from 10 sources (see all 63):
    (articles sorted by number of sources associating them with DDIT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. (PubMed id 11884613)1, 2, 3 Shoshani T....Feinstein E. (Mol. Cell. Biol. 2002)
    2. Regulation of mTOR and cell growth in response to energy stress by REDD1. (PubMed id 15988001)1, 2, 9 Sofer A.... Ellisen L.W. (Mol. Cell. Biol. 2005)
    3. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PubMed id 15632201)1, 2, 9 Corradetti M.N.... Guan K.-L. (J. Biol. Chem. 2005)
    4. TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1. (PubMed id 21460850)1, 2 Jin H.O.... Park I.C. (Oncogene 2011)
    5. Structural analysis and functional implications of the negative mTORC1 regulator REDD1. (PubMed id 20166753)1, 2 Vega-Rubin-de-Celis S.... Zhang X. (Biochemistry 2010)
    6. REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A- DDB1 ubiquitin ligase. (PubMed id 19557001)1, 2 Katiyar S.... Chiang G.G. (EMBO Rep. 2009)
    7. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. (PubMed id 17005863)1, 2 Malagelada C.... Greene L.A. (J. Neurosci. 2006)
    8. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. (PubMed id 15592522)1, 2 Schwarzer R....Kaufmann J. (Oncogene 2005)
    9. Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity. (PubMed id 14646594)1, 2 Kim J.-R....Kim Y.-S. (Exp. Mol. Med. 2003)
    10. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. (PubMed id 12453409)1, 2 Ellisen L.W.... Haber D.A. (Mol. Cell 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54541 HGNC: 24944 AceView: DDIT4 Ensembl:ENSG00000168209 euGenes: HUgn54541
    ECgene: DDIT4 Kegg: 54541 H-InvDB: DDIT4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDIT4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDIT4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDIT4 gene:
    Search GeneIP for patents involving DDIT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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