Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDIT4 Gene

protein-coding   GIFtS: 60
GCID: GC10P074033

DNA-Damage-Inducible Transcript 4

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DNA-Damage-Inducible Transcript 41 2     RTP8013 5
REDD12 3 5     HIF-1 Responsive RTP8011
Protein Regulated In Development And DNA Damage Response 12 3     Dig22
REDD-12 3     DNA Damage-Inducible Transcript 4 Protein2
HIF-1 Responsive Protein RTP8012 3     

External Ids:    HGNC: 249441   Entrez Gene: 545412   Ensembl: ENSG000001682097   OMIM: 6077295   UniProtKB: Q9NX093   

Export aliases for DDIT4 gene to outside databases

Previous GC identifers: GC00U914339 GC10P073379 GC10P073703 GC10P068028


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DDIT4 Gene: 
DDIT4 (DNA-damage-inducible transcript 4) is a protein-coding gene. Diseases associated with DDIT4 include oral lichen planus, and lichen planus, and among its related super-pathways are p70S6K Signaling and Transcription Receptor-mediated HIF regulation. GO annotations related to this gene include 14-3-3 protein binding. An important paralog of this gene is DDIT4L.

UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
Function: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target
of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1,
the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and
cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response
to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it
mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for
mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal
differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal
neuron migration during embryonic brain development. Plays a role in neuronal cell death

Gene Wiki entry for DDIT4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDIT4 gene promoter:
         GR   FOXF2   p53   Brachyury   FOXD3   Nkx2-5   Arnt   MEF-2A   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDIT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDIT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDIT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

DDIT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDIT4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P074033:  view genomic region     (about GC identifiers)

Start:
74,033,677 bp from pter      End:
74,035,797 bp from pter
Size:
2,121 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09 (See protein sequence)
Recommended Name: DNA damage-inducible transcript 4 protein  
Size: 232 amino acids; 25371 Da
Subunit: Monomer. Interacts with BTRC. Identified in a complex with CUL4A, DDB1 and BTRC. Interacts with TXNIP;
this inhibits the proteasomal degradation of DDIT4
Subcellular location: Mitochondrion (By similarity). Cytoplasm, cytosol
1 PDB 3D structure from and Proteopedia for DDIT4:
3LQ9 (3D)    
Secondary accessions: Q9H0S3

Explore the universe of human proteins at neXtProt for DDIT4: NX_Q9NX09

Explore proteomics data for DDIT4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by GSK3B; this promotes proteasomal degradation
  • UniProtKB: Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as
    substrate-recognition component, leading to its proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NX09

  • DDIT4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDIT4 Protein Expression
    REFSEQ proteins: NP_061931.1  
    ENSEMBL proteins: 
     ENSP00000307305  

    Human Recombinant Protein Products for DDIT4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DDIT4
    OriGene Protein Over-expression Lysate for DDIT4
    OriGene MassSpec for DDIT4 
    OriGene Custom Protein Services for DDIT4
    GenScript Custom Purified and Recombinant Proteins Services for DDIT4
    Novus Biologicals DDIT4 Proteins
    Novus Biologicals DDIT4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for DDIT4
    Cloud-Clone Corp. Proteins for DDIT4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IEA--

    DDIT4 for ontologies           About GeneDecksing



    DDIT4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DDIT4
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DDIT4 
    OriGene Antibodies for DDIT4
    OriGene Custom Antibody Services for DDIT4
    GenScript Custom Superior Antibodies Services for DDIT4
    Novus Biologicals DDIT4 Antibodies
    Abcam antibodies for DDIT4
    Cloud-Clone Corp. Antibodies for DDIT4 
    ThermoFisher Antibodies for DDIT4
    LSBio Antibodies in human, mouse, rat for DDIT4 

    Assay Products for DDIT4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDIT4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDIT4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDIT4 
    Cloud-Clone Corp. CLIAs for DDIT4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR012918 RTP801-like

    Graphical View of Domain Structure for InterPro Entry Q9NX09

    ProtoNet protein and cluster: Q9NX09

    1 Blocks protein domain: IPB012918 RTP801

    UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
    Similarity: Belongs to the DDIT4 family


    DDIT4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDIT4_HUMAN, Q9NX09
    Function: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target
    of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1,
    the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and
    cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response
    to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it
    mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for
    mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal
    differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal
    neuron migration during embryonic brain development. Plays a role in neuronal cell death
    Induction: Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63
    in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA
    alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and
    HIF1A-dependent but TP53/TP63-independent mechanism (at protein level)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:007188914-3-3 protein binding IEA--
         
    DDIT4 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ddit4):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  reproductive system 
     vision/eye 

    DDIT4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ddit4tm1.1Sinc for DDIT4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDIT4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDIT4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDIT4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDIT4 

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDIT4:
    hsa-mir-181a (MIRT005575), hsa-mir-221 (MIRT003358)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDIT4
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate DDIT4 (see all 65):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidDDIT4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDIT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDIT4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDIT4
    Sirion Biotech Customized adenovirus for overexpression of DDIT4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DDIT4 (see all 7)
    OriGene ORF clones in mouse, rat for DDIT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDIT4 (NM_019058)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDIT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDIT4
    Sirion Biotech Customized lentivirus for stable overexpression of DDIT4 
                         Customized lentivirus expression plasmids for stable overexpression of DDIT4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDIT4
    Search LifeMap BioReagents cell lines for DDIT4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DDIT4 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1p70S6K Signaling
    mTOR Pathway0.54
    2Translation Insulin regulation of translation
    mTOR signaling pathway0.34
    3Energy dependent regulation of mTOR by LKB1-AMPK
    TOR signaling0.33
    4DNA Damage
    DNA Damage0.32
    5mTOR signaling pathway
    mTOR signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DDIT4
        mTOR Pathway

    2 Cell Signaling Technology (CST) Pathways for DDIT4
        PI3K / Akt Signaling
    DNA Damage

    3 BioSystems Pathways for DDIT4
        TOR signaling
    mTOR signaling pathway
    Direct p53 effectors


    3         Kegg Pathways  (Kegg details for DDIT4):
        mTOR signaling pathway
    PI3K-Akt signaling pathway
    MicroRNAs in cancer


    DDIT4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDIT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/19 Interacting proteins for DDIT4 (Q9NX092, 3 ENSP000003073054) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2972, 3, ENSP000003592064MINT-7255840 MINT-7255886 I2D: score=1 STRING: ENSP00000359206
    PDPK1O155302, 3, ENSP000003442204MINT-8265522 I2D: score=2 STRING: ENSP00000344220
    PLCG1P191742, 3, ENSP000002440074MINT-7255813 I2D: score=1 STRING: ENSP00000244007
    LRIF1Q5T3J32, 3MINT-65448 I2D: score=4 
    DDB1Q165312, 3, ENSP000003017644MINT-7255853 MINT-7255865 I2D: score=1 STRING: ENSP00000301764
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA--
    GO:0001764neuron migration ISS--
    GO:0007420brain development ISS--
    GO:0008283cell proliferation ISS--
    GO:0009968negative regulation of signal transduction ----

    DDIT4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDIT4

    Search CenterWatch for drugs/clinical trials and news about DDIT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDIT4 gene: 
    NM_019058.2  

    Unigene Cluster for DDIT4:

    DNA-damage-inducible transcript 4
    Hs.744875  [show with all ESTs]
    Unigene Representative Sequence: AF335324
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307365(uc001jsx.1) ENST00000473155 ENST00000471240
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDIT4
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate DDIT4 (see all 65):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidDDIT4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDIT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDIT4
    Clone
    Products:
         
    OriGene clones in human, mouse for DDIT4 (see all 7)
    OriGene ORF clones in mouse, rat for DDIT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDIT4 (NM_019058)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDIT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDIT4
    Sirion Biotech Customized lentivirus for stable overexpression of DDIT4 
                         Customized lentivirus expression plasmids for stable overexpression of DDIT4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDIT4
    OriGene qSTAR qPCR primer pairs in human, mouse for DDIT4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDIT4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDIT4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDIT4

    Additional mRNA sequence: 

    AF335324.1 AK000507.1 AL136668.1 AY090097.1 BC000708.1 BC007714.1 BC015236.1 

    23 DOTS entries:

    DT.100866166  DT.119273  DT.100676352  DT.100869730  DT.95278034  DT.91860446  DT.91769173  DT.100765333 
    DT.95278047  DT.91769145  DT.121283566  DT.121283561  DT.100038734  DT.100676361  DT.86840422  DT.100035460 
    DT.100676350  DT.100716484  DT.91769164  DT.100864346  DT.95233975  DT.95278033  DT.97770089 

    24/902 AceView cDNA sequences (see all 902):

    AI679365 BM854380 T33871 AA548372 BE907496 AI559582 AI978661 BU682691 
    CD629632 BM561714 AI765626 CF264802 AW151738 BQ435193 BP374482 AA236317 
    BC007714 BE888365 AW316834 BQ062249 BI518919 AI963444 CA395008 T32842 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DDIT4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:              -                     
    SP2:                                    
    SP3:        -     -                     
    SP4:              -                     


    ECgene alternative splicing isoforms for DDIT4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDIT4 expression in normal human tissues (normalized intensities)      DDIT4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTTAAAA
    DDIT4 Expression
    About this image


    DDIT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Fibroblast (Uncategorized)    fully expand to see all 2 entries
             Human Prostate Fibroblasts (HPrF)   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             pre Conventional Dendritic Cells Peripheral Blood
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Uterus (Reproductive System)
             CERVIX   
     
     Lymph (Cardiovascular System)
             Human Lymphatic Fibroblasts (HLF)   

    See DDIT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDIT4

    SOURCE GeneReport for Unigene cluster: Hs.744875

    UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
    Tissue specificity: Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in
    substantia nigra neurons from Parkinson disease patients (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including DDIT4: 
              mTOR Signaling in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDIT4
    OriGene qSTAR qPCR primer pairs in human, mouse for DDIT4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDIT4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDIT4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDIT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DDIT4 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddit41 , 5 DNA-damage-inducible transcript 41, 5 87.77(n)1
    92.58(a)1
      10 (29.66 cM)5
    747471  NM_029083.21  NP_083359.11 
     599496755 
    lizard
    (Anolis carolinensis)
    Reptilia DDIT46
    Uncharacterized protein
    72(a)
    1 ↔ 1
    3(51710509-51715418)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC644532 hypothetical protein MGC64453 73.26(n)    BC054246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb8212 sbcb821 73.33(n)   378866  BC053258.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta chrb6
    scyl6
    scylla
    15(a)
    14(a)
    many ↔ many
    many ↔ many
    3L(11480650-11492212)
    3L(11245410-11248343)


    ENSEMBL Gene Tree for DDIT4 (if available)
    TreeFam Gene Tree for DDIT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDIT4 gene
    DDIT4L2  
    1 SIMAP similar gene for DDIT4 using alignment to 1 protein entry:     DDIT4_HUMAN:
    DDIT4L

    DDIT4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/122 SNPs in DDIT4 are shown (see all 122)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs64806081,2
    C,F,A--74031694(+) ACCTGT/CAGTTC 1 -- us2k16Minor allele frequency- C:0.45NA WA CSA 11
    rs1848365421,2
    --74031748(+) GAGGCA/GGAGCT 1 -- us2k10--------
    rs1879814871,2
    --74031830(+) AAAAAA/GAAGAA 1 -- us2k10--------
    rs578196401,2
    C--74031832(+) AAAAAAA/-GAAGA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs2014721791,2
    C--74031833(-) TTCTTC/TTNNNN 1 -- us2k10--------
    rs2001219681,2
    C--74031851(+) AAAAA-/AC    
       ATCGT
    AACTC
    1 -- us2k10--------
    rs38344181,2
    C--74031942(+) GATCT-/TCTCTCTG 2 -- us2k1 cds10--------
    rs341652101,2
    C--74031942(+) TCAGA-/TCTTCTCT 1 -- us2k11Minor allele frequency- TCT:0.00NA 2
    rs2004117181,2
    --74031946(+) ATCTT-/CTCTCTGG 1 -- us2k10--------
    rs1464711331,2
    --74032116(+) TAAGGC/TTCCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDIT4 (74033677 - 74035797 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDIT4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv895721CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DDIT4
    DNA2.0 Custom Variant and Variant Library Synthesis for DDIT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607729    OMIM disorders: --

    10 diseases for DDIT4:    About MalaCards
    oral lichen planus    lichen planus    tuberous sclerosis    hypoxia
    parkinson's disease    renal cell carcinoma    squamous cell carcinoma    gastric cancer
    neuronitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for DDIT4:
    Tuberous sclerosis

    DDIT4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): DDIT4
    Human Genome Epidemiology (HuGE) Navigator: DDIT4 (1 document)

    Export disorders for DDIT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDIT4 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with DDIT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. (PubMed id 11884613)1, 2, 3 Shoshani T....Feinstein E. (2002)
    2. Regulation of mTOR and cell growth in response to energy stress by REDD1. (PubMed id 15988001)1, 2, 9 Sofer A.... Ellisen L.W. (2005)
    3. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PubMed id 15632201)1, 2, 9 Corradetti M.N.... Guan K.-L. (2005)
    4. TXNIP potentiates Redd1-induced mTOR suppression thro ugh stabilization of Redd1. (PubMed id 21460850)1, 2 Jin H.O....Park I.C. (2011)
    5. Structural analysis and functional implications of th e negative mTORC1 regulator REDD1. (PubMed id 20166753)1, 2 Vega-Rubin-de-Celis S....Zhang X. (2010)
    6. REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. (PubMed id 19557001)1, 2 Katiyar S....Chiang G.G. (2009)
    7. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. (PubMed id 17005863)1, 2 Malagelada C.... Greene L.A. (2006)
    8. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. (PubMed id 15592522)1, 2 Schwarzer R....Kaufmann J. (2005)
    9. Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity. (PubMed id 14646594)1, 2 Kim J.-R....Kim Y.-S. (2003)
    10. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. (PubMed id 12453409)1, 2 Ellisen L.W.... Haber D.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54541 HGNC: 24944 AceView: DDIT4 Ensembl:ENSG00000168209 euGenes: HUgn54541
    ECgene: DDIT4 Kegg: 54541 H-InvDB: DDIT4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDIT4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDIT4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDIT4 gene:
    Search GeneIP for patents involving DDIT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of DDIT4
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DDIT4   OriGene RNAi products in human, mouse, rat for DDIT4  
     OriGene qPCR primer pairs and template standards for DDIT4   OriGene Protein Over-expression Lysate for DDIT4  
     OriGene MassSpec something-or-other for DDIT4   OriGene clones in human, mouse for DDIT4  
     OriGene qSTAR qPCR primer pairs in human, mouse for DDIT4   OriGene Purified Protein for DDIT4  
     OriGene ORF clones in mouse, rat for DDIT4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDIT4   OriGene Custom Protein Services for DDIT4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDIT4
     QIAGEN SeqTarget long-range PCR primers for resequencing DDIT4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDIT4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDIT4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDIT4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDIT4
     GenScript Custom Purified and Recombinant Proteins Services for DDIT4 GenScript cDNA clones with any tag delivered in your preferred vector for DDIT4
     GenScript Custom Assay Services for DDIT4 GenScript Custom Superior Antibodies Services for DDIT4
     GenScript Custom overexpressing Cell Line Services for DDIT4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for DDIT4 

     Regulatory tfbs in DDIT4 promoter
     Search Chromatin IP Primers for DDIT4
     RT2 qPCR Primer Assay in human, mouse, rat DDIT4
     GNC Network for DDIT4
     SABiosciences PCR Arrays including human, mouse, rat DDIT4
     Search Tocris compounds for DDIT4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DDIT4 antibodies
     DDIT4 proteins
     DDIT4 lysates
     Antibodies for DDIT4
     See all of Abcam's Antibodies, Kits and Proteins for DDIT4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DDIT4




     Proteins for DDIT4
     Antibodies for DDIT4
     ELISAs for DDIT4
     CLIAs for DDIT4
     Search LifeMap BioReagents cell lines for DDIT4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4
     SwitchGear 3'UTR luciferase reporter plasmids for DDIT4
     SwitchGear Promoter luciferase reporter plasmids for DDIT4
     ThermoFisher Antibodies for DDIT4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDIT4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DDIT4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDIT4
    Customized:
     lentivirus for stable overexpression of DDIT4
     lentivirus expression plasmids for stable overexpression of DDIT4
     adenovirus for overexpression of DDIT4
     LSBio Antibodies in human, mouse, rat for DDIT4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DDIT4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4