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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDIT4 Gene

protein-coding   GIFtS: 59
GCID: GC10P074033

DNA-damage-inducible transcript 4
 Explore 12 diseases affiliated with
DDIT4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DDIT4    

Aliases
for DDIT4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DNA-Damage-Inducible Transcript 41 2     Protein Regulated In Development And DNA Damage Response 12 3
REDD11 2 3 5     HIF-1 Responsive Protein RTP8012 3
REDD-11 2 3     FLJ205001
RTP8011 3 5     DNA Damage-Inducible Transcript 4 Protein2
Dig21 2     

External Ids:    HGNC: 249441   Entrez Gene: 545412   Ensembl: ENSG000001682097   OMIM: 6077295   UniProtKB: Q9NX093   

Export aliases for DDIT4 gene to outside databases

Previous GC identifers: GC00U914339 GC10P073379 GC10P073703 GC10P068028


Summaries
for DDIT4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
Function: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of
rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the
TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular
stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage
via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1
inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense
against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite
outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic
brain development. Plays a role in neuronal cell death

Gene Wiki entry for DDIT4


Genomic Views
for DDIT4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDIT4 gene promoter:
         GR   FOXF2   p53   Brachyury   FOXD3   Nkx2-5   Arnt   MEF-2A   GR-alpha   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDIT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDIT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDIT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

DDIT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDIT4 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P074033:  view genomic region     (about GC identifiers)

Start:
 74,033,677 bp from pter      End:
 74,035,797 bp from pter
Size:
 2,121 bases      Orientation:
 plus strand

Proteins
for DDIT4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09 (See protein sequence)
Recommended Name: DNA damage-inducible transcript 4 protein  
Size: 232 amino acids; 25371 Da
Subunit: Monomer. Interacts with BTRC. Identified in a complex with CUL4A, DDB1 and BTRC. Interacts with TXNIP; this
inhibits the proteasomal degradation of DDIT4
Subcellular location: Mitochondrion (By similarity). Cytoplasm, cytosol
1 PDB 3D structure from and Proteopedia for DDIT4:
3LQ9 (3D)    
Secondary accessions: Q9H0S3

Explore the universe of human proteins at neXtProt for DDIT4: NX_Q9NX09

Post-translational modifications:

  • Phosphorylated by GSK3B; this promotes proteasomal degradation1
  • Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as substrate-recognition
    • component, leading to its proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NX09

    • DDIT4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061931.1  
    ENSEMBL proteins: 
     ENSP00000307305  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: DDIT4
    OriGene Protein Over-expression Lysate: DDIT4
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    Novus Biologicals DDIT4 Proteins
    Novus Biologicals DDIT4 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for DDIT4
    Uscn Proteins for DDIT4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol IEA--


    DDIT4 for ontologies           About GeneDecksing



    DDIT4 Antibody Products: 
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    Abcam antibodies for DDIT4 
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    ThermoFisher Antibodies for DDIT4

    Assay Products for DDIT4: 
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    Uscn ELISAs and CLIAs for DDIT4

    Protein Domains /
    Families
    for DDIT4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DDIT4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR012918 RTP801-like

    Graphical View of Domain Structure for InterPro Entry Q9NX09

    ProtoNet protein and cluster: Q9NX09

    1 Blocks protein family: IPB012918 RTP801

    UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
    Similarity: Belongs to the DDIT4 family


    Function
    for DDIT4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
    Function: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of
    rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the
    TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular
    stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage
    via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1
    inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense
    against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite
    outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic
    brain development. Plays a role in neuronal cell death
    Induction: Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in
    primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation.
    Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but
    TP53/TP63-independent mechanism (at protein level)

    miRNA
    Products:            		miRTarBase miRNAs that target DDIT4:
    hsa-mir-181a (MIRT005575), hsa-mir-221 (MIRT003358)

    OriGene 3'-UTR Clone: DDIT4
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDIT4
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate DDIT4 (see all 65):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: DDIT4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDIT4 (see all 7)
    OriGene shRNA RFP: DDIT4
    OriGene siRNA: DDIT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDIT4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DDIT4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDIT4 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: DDIT4 (NM_019058)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDIT4 

    Cell Line
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    Search LifeMap BioReagents cell lines for DDIT4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:007188914-3-3 protein binding IEA--


    DDIT4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Ddit4tm1.1Sinc for DDIT4
         6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Ddit4):
     cardiovascular system  cellular  homeostasis/metabolism  mortality/aging  reproductive system 
     vision/eye 

    DDIT4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DDIT4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PI3K / Akt Signaling
    		PI3K / Akt Signaling1.00
    2mTOR signaling pathway
    		mTOR signaling pathway1.00
    3Direct p53 effectors
    		Direct p53 effectors1.00
    4DNA Damage
    		DNA Damage1.00
    5p70S6K Signaling
    		mTOR Pathway0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DDIT4
        mTOR Pathway

    2 Cell Signaling Technology (CST) Pathways for DDIT4
        PI3K / Akt Signaling
    DNA Damage

    3 BioSystems Pathways for DDIT4 
        TOR signaling
    mTOR signaling pathway
    Direct p53 effectors


    1         Kegg Pathway  (Kegg details for DDIT4):
        mTOR signaling pathway


    DDIT4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDIT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/19 Interacting proteins for DDIT4 (Q9NX092, 3 ENSP000003073054) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2972, 3, ENSP000003592064MINT-7255840 MINT-7255886 I2D: score=1 STRING: ENSP00000359206
    PDPK1O155302, 3, ENSP000003442204MINT-8265522 I2D: score=2 STRING: ENSP00000344220
    PLCG1P191742, 3, ENSP000002440074MINT-7255813 I2D: score=1 STRING: ENSP00000244007
    LRIF1Q5T3J32, 3MINT-65448 I2D: score=4 
    DDB1Q165312, 3, ENSP000003017644MINT-7255853 MINT-7255865 I2D: score=1 STRING: ENSP00000301764
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA--
    GO:0001764neuron migration ISS--
    GO:0006915apoptotic process ----
    GO:0007420brain development ISS--
    GO:0008283cell proliferation ISS--


    DDIT4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DDIT4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDIT4
    Search CenterWatch for drugs/clinical trials and news about DDIT4 

    Transcripts
    for DDIT4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDIT4 gene: 
    NM_019058.2  

    Unigene Cluster for DDIT4:

    DNA-damage-inducible transcript 4
    Hs.523012  [show with all ESTs]
    Unigene Representative Sequence: AF335324
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307365(uc001jsx.1) ENST00000473155 ENST00000471240 ENST00000491934


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDIT4
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate DDIT4 (see all 65):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-199a-3p hsa-miR-30d hsa-miR-30a hsa-miR-548a-5p hsa-miR-200b hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: DDIT4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDIT4 (see all 7)
    OriGene shRNA RFP: DDIT4
    OriGene siRNA: DDIT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDIT4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDIT4 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDIT4
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DDIT4 (NM_019058)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDIT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDIT4 
    Primer
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    Additional cDNA sequence: 

    AF335324.1 AK000507.1 AL136668.1 AY090097.1 BC000708.1 BC007714.1 BC015236.1 

    24/25 DOTS entries (see all 25):

    DT.100866166  DT.119273  DT.100676352  DT.100869730  DT.95278034  DT.91860446  DT.91769173  DT.100765333 
    DT.95278047  DT.121283561  DT.91769145  DT.100676361  DT.121283566  DT.100038734  DT.86840422  DT.100035460 
    DT.100676350  DT.100716484  DT.100864346  DT.121283621  DT.91769164  DT.95278033  DT.100059763  DT.95233975 

    24/902 AceView cDNA sequences (see all 902):

    AI690851 CD518235 BQ881033 CA417402 BM561714 BE888365 AW316834 BC007714 
    AW006110 BU500762 BI832495 BM353038 AA256134 T35952 BI257940 AW469295 
    AI890084 BM888117 CR624887 BX335728 BQ063169 CF139120 AI275808 BI160581 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DDIT4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:              -                     
    SP2:                                    
    SP3:        -     -                     
    SP4:              -                     


    ECgene alternative splicing isoforms for DDIT4

    Expression
    for DDIT4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDIT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGTTAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DDIT4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Adult human kidney epithelial cells (Primary Cell)Kidney
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DDIT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDIT4

    SOURCE GeneReport for Unigene cluster: Hs.523012

    UniProtKB/Swiss-Prot: DDIT4_HUMAN, Q9NX09
    Tissue specificity: Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in
    substantia nigra neurons from Parkinson disease patients (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including DDIT4: 
              mTOR Signaling in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDIT4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDIT4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDIT4

    Orthologs
    for DDIT4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DDIT4 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ddit41 , 5 DNA-damage-inducible transcript 41, 5 87.77(n)1
    92.58(a)1    		   10 (29.66 cM)5
    747471  NM_029083.21  NP_083359.11 
     599496755 
    lizard
    (Anolis carolinensis)    		 Reptilia DDIT46
    		 --
    		 71(a)
    		 1 ↔ 1
    		 3(51711251-51713703)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC644532 hypothetical protein MGC64453 73.26(n)    BC054246.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb8212 sbcb821 73.33(n)   378866  BC053258.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta chrb6
    scyl6
    		 scylla
    		 18(a)
    16(a)
    		 many ↔ many
    many ↔ many
    		 3L(11480650-11492212)
    3L(11245410-11248343)


    ENSEMBL Gene Tree for DDIT4 (if available)
    TreeFam Gene Tree for DDIT4 (if available) 

    Paralogs
    for DDIT4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDIT4 gene
    DDIT4L2  
    1 SIMAP similar gene for DDIT4 using alignment to 1 protein entry:     DDIT4_HUMAN:
    DDIT4L

    DDIT4 for paralogs           About GeneDecksing



    Genomic Variants
    for DDIT4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/96 NCBI SNPs in DDIT4 are shown (see all 96)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs64806081,2
    		C,F,A,--74031694(+) ACCTGT/CAGTTC 1 -- us2k16Minor allele frequency- C:0.45NA WA CSA 11
    rs1848365421,2
    		--74031748(+) GAGGCA/GGAGCT 1 -- us2k10--------
    rs578196401,2
    		C--74031816(+) AAAAGAA/-AAGAA 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1879814871,2
    		--74031830(+) AAAAAA/GAAGAA 1 -- us2k10--------
    rs2014721791,2
    		C--74031833(-) TTCTTC/TTNNNN 1 -- us2k10--------
    rs2001219681,2
    		--74031851(+) AAAAA-/AC    
       ATCGT    AACTC     		1 -- us2k10--------
    rs2022387121,2
    		--74031941(+) TTCAG-/ATCTTCTC 1 -- us2k10--------
    rs38344181,2
    		C--74031942(+) GATCT-/TCTCTCTG 1 -- us2k10--------
    rs341652101,2
    		C,--74031942(+) TCAGA-/TCTTCTCT 1 -- us2k11Minor allele frequency- TCT:0.00NA 2
    rs2004117181,2
    		--74031946(+) ATCTT-/CTCTCTGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DDIT4 (74033677 - 74035797 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DDIT4: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDIT4
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    Disorders / Diseases
    for DDIT4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DDIT4 for disorders           About GeneDecksing

    OMIM gene information: 607729    OMIM disorders: --

    12 diseases for DDIT4:    About MalaCards
    lichen planus    oral lichen planus    tuberous sclerosis    renal cell carcinoma
    squamous cell carcinoma    emphysema    parkinson's disease    breast cancer
    ataxia    carcinoma    hypoxia    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: DDIT4 (1 document)

    Export disorders for DDIT4 gene to outside databases

    Publications
    for DDIT4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDIT4 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with DDIT4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. (PubMed id 11884613)1, 2, 3 Shoshani T....Feinstein E. (2002)
    2. Regulation of mTOR and cell growth in response to energy stress by REDD1. (PubMed id 15988001)1, 2, 9 Sofer A.... Ellisen L.W. (2005)
    3. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PubMed id 15632201)1, 2, 9 Corradetti M.N.... Guan K.-L. (2005)
    4. TXNIP potentiates Redd1-induced mTOR suppression thro ugh stabilization of Redd1. (PubMed id 21460850)1, 2 Jin H.O....Park I.C. (2011)
    5. Structural analysis and functional implications of th e negative mTORC1 regulator REDD1. (PubMed id 20166753)1, 2 Vega-Rubin-de-Celis S....Zhang X. (2010)
    6. REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase. (PubMed id 19557001)1, 2 Katiyar S....Chiang G.G. (2009)
    7. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. (PubMed id 17005863)1, 2 Malagelada C.... Greene L.A. (2006)
    8. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. (PubMed id 15592522)1, 2 Schwarzer R....Kaufmann J. (2005)
    9. Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: involvement of RTP801 in amyloid beta-peptide toxicity. (PubMed id 14646594)1, 2 Kim J.-R....Kim Y.-S. (2003)
    10. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. (PubMed id 12453409)1, 2 Ellisen L.W.... Haber D.A. (2002)

    External Searches for DDIT4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing DDIT4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54541 HGNC: 24944 AceView: DDIT4 Ensembl:ENSG00000168209 euGenes: HUgn54541
    ECgene: DDIT4 Kegg: 54541 H-InvDB: DDIT4

    Other Databases showing DDIT4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDIT4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDIT4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DDIT4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDIT4 gene:
    Search GeneIP for patents involving DDIT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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