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Aliases for DDIT4 Gene

Aliases for DDIT4 Gene

  • DNA Damage Inducible Transcript 4 2 3 5
  • Protein Regulated In Development And DNA Damage Response 1 3 4
  • HIF-1 Responsive Protein RTP801 3 4
  • REDD-1 3 4
  • REDD1 3 4
  • DNA Damage-Inducible Transcript 4 Protein 3
  • DNA-Damage-Inducible Transcript 4 2
  • HIF-1 Responsive RTP801 2
  • RTP801 4
  • Dig2 3

External Ids for DDIT4 Gene

Previous GeneCards Identifiers for DDIT4 Gene

  • GC00U914339
  • GC10P073379
  • GC10P073703
  • GC10P074033
  • GC10P068028

Summaries for DDIT4 Gene

GeneCards Summary for DDIT4 Gene

DDIT4 (DNA Damage Inducible Transcript 4) is a Protein Coding gene. Among its related pathways are mTOR signaling pathway (KEGG) and TP53 Regulates Metabolic Genes. GO annotations related to this gene include 14-3-3 protein binding. An important paralog of this gene is DDIT4L.

UniProtKB/Swiss-Prot for DDIT4 Gene

  • Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.

Gene Wiki entry for DDIT4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDIT4 Gene

Genomics for DDIT4 Gene

Regulatory Elements for DDIT4 Gene

Enhancers for DDIT4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F072318 1.3 FANTOM5 ENCODE 21.8 +48.2 48175 8.0 CREB3L1 YBX1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D DNAJB12 DDIT4 ECD PSAP DNAJC9 ANAPC16 NUDT13 MICU1 ENSG00000269926
GH10F072307 1.4 FANTOM5 Ensembl ENCODE 19.4 +36.0 35982 5.0 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF766 CBX5 FOS KLF13 ZNF263 DNAJB12 DDIT4 ENSG00000200170 ANAPC16 ASCC1 PSAP DNAJC9 ENSG00000269926
GH10F072241 1.4 VISTA FANTOM5 Ensembl ENCODE 15.5 -20.1 -20119 25.2 MLX CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 ECD ANAPC16 DNAJC9 ENSG00000272599 ASCC1 DNAJB12 DDIT4 C10orf105 ENSG00000200170 RPL17P50
GH10F072314 1.3 FANTOM5 ENCODE 14.7 +42.1 42091 3.3 PKNOX1 MLX ARID4B DMAP1 YY1 SP5 MXD4 REST KAT8 MEF2D DNAJB12 DDIT4 DNAJC9 PSAP ENSG00000269926
GH10F072305 1.1 Ensembl ENCODE 12.7 +32.2 32182 2.2 BCOR SMARCA5 RNF2 NR4A1 ZMYM3 ZNF175 EBF1 ZFHX2 ADNP THRAP3 DNAJB12 DDIT4 ANAPC16 ENSG00000269926
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DDIT4 on UCSC Golden Path with GeneCards custom track

Promoters for DDIT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001016962 781 3801 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for DDIT4 Gene

Chromosome:
10
Start:
72,273,919 bp from pter
End:
72,276,039 bp from pter
Size:
2,121 bases
Orientation:
Plus strand

Genomic View for DDIT4 Gene

Genes around DDIT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDIT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDIT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDIT4 Gene

Proteins for DDIT4 Gene

  • Protein details for DDIT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX09-DDIT4_HUMAN
    Recommended name:
    DNA damage-inducible transcript 4 protein
    Protein Accession:
    Q9NX09
    Secondary Accessions:
    • Q9H0S3

    Protein attributes for DDIT4 Gene

    Size:
    232 amino acids
    Molecular mass:
    25371 Da
    Quaternary structure:
    • Monomer. Interacts with BTRC. Identified in a complex with CUL4A, DDB1 and BTRC. Interacts with TXNIP; this inhibits the proteasomal degradation of DDIT4.

    Three dimensional structures from OCA and Proteopedia for DDIT4 Gene

neXtProt entry for DDIT4 Gene

Post-translational modifications for DDIT4 Gene

  • Phosphorylated by GSK3B; this promotes proteasomal degradation.
  • Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as substrate-recognition component, leading to its proteasomal degradation.
  • Ubiquitination at Lys 129, Lys 188, and Lys 220
  • Modification sites at PhosphoSitePlus

Other Protein References for DDIT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DDIT4 (DDIT4)

No data available for DME Specific Peptides for DDIT4 Gene

Domains & Families for DDIT4 Gene

Protein Domains for DDIT4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DDIT4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NX09

UniProtKB/Swiss-Prot:

DDIT4_HUMAN :
  • Belongs to the DDIT4 family.
Family:
  • Belongs to the DDIT4 family.
genes like me logo Genes that share domains with DDIT4: view

No data available for Gene Families for DDIT4 Gene

Function for DDIT4 Gene

Molecular function for DDIT4 Gene

UniProtKB/Swiss-Prot Function:
Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.
UniProtKB/Swiss-Prot Induction:
Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism (at protein level).

Gene Ontology (GO) - Molecular Function for DDIT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071889 14-3-3 protein binding IEA --
genes like me logo Genes that share ontologies with DDIT4: view
genes like me logo Genes that share phenotypes with DDIT4: view

Animal Models for DDIT4 Gene

MGI Knock Outs for DDIT4:

Animal Model Products

miRNA for DDIT4 Gene

miRTarBase miRNAs that target DDIT4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDIT4 Gene

Localization for DDIT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDIT4 Gene

Mitochondrion. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDIT4 Gene COMPARTMENTS Subcellular localization image for DDIT4 gene
Compartment Confidence
cytosol 5
mitochondrion 4
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DDIT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm IEA,IDA 12453409
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DDIT4: view

Pathways & Interactions for DDIT4 Gene

genes like me logo Genes that share pathways with DDIT4: view

Pathways by source for DDIT4 Gene

1 GeneTex pathway for DDIT4 Gene
2 Cell Signaling Technology pathways for DDIT4 Gene
3 BioSystems pathways for DDIT4 Gene
2 R&D Systems pathways for DDIT4 Gene
1 Qiagen pathway for DDIT4 Gene

Gene Ontology (GO) - Biological Process for DDIT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 20166753
GO:0001764 neuron migration ISS --
GO:0006915 apoptotic process IEA --
GO:0007420 brain development ISS --
GO:0008283 cell proliferation ISS --
genes like me logo Genes that share ontologies with DDIT4: view

No data available for SIGNOR curated interactions for DDIT4 Gene

Transcripts for DDIT4 Gene

mRNA/cDNA for DDIT4 Gene

Unigene Clusters for DDIT4 Gene

DNA-damage-inducible transcript 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDIT4 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2:
SP3: - -
SP4: -

Relevant External Links for DDIT4 Gene

GeneLoc Exon Structure for
DDIT4
ECgene alternative splicing isoforms for
DDIT4

Expression for DDIT4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DDIT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDIT4 Gene

This gene is overexpressed in Cardia (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DDIT4 Gene



Protein tissue co-expression partners for DDIT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of DDIT4 Gene:

DDIT4

SOURCE GeneReport for Unigene cluster for DDIT4 Gene:

Hs.744875

mRNA Expression by UniProt/SwissProt for DDIT4 Gene:

Q9NX09-DDIT4_HUMAN
Tissue specificity: Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients (at protein level).
genes like me logo Genes that share expression patterns with DDIT4: view

Primer Products

No data available for mRNA differential expression in normal tissues for DDIT4 Gene

Orthologs for DDIT4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDIT4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDIT4 34 35
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia DDIT4 34 35
  • 93.19 (n)
cow
(Bos Taurus)
Mammalia DDIT4 34 35
  • 90.68 (n)
mouse
(Mus musculus)
Mammalia Ddit4 34 16 35
  • 87.34 (n)
rat
(Rattus norvegicus)
Mammalia Ddit4 34
  • 87.34 (n)
oppossum
(Monodelphis domestica)
Mammalia DDIT4 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDIT4 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDIT4 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddit4 34
  • 60.11 (n)
MGC76013 34
African clawed frog
(Xenopus laevis)
Amphibia MGC64453 34
zebrafish
(Danio rerio)
Actinopterygii ddit4 34 35
  • 57.63 (n)
sbcb821 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10950 34
fruit fly
(Drosophila melanogaster)
Insecta chrb 35
  • 15 (a)
ManyToMany
scyl 35
  • 15 (a)
ManyToMany
Species where no ortholog for DDIT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDIT4 Gene

ENSEMBL:
Gene Tree for DDIT4 (if available)
TreeFam:
Gene Tree for DDIT4 (if available)

Paralogs for DDIT4 Gene

Paralogs for DDIT4 Gene

(1) SIMAP similar genes for DDIT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDIT4: view

Variants for DDIT4 Gene

Sequence variations from dbSNP and Humsavar for DDIT4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1053639 -- 72,275,283(+) ATTCC(A/T)GTGGT utr-variant-3-prime
rs10566169 -- 72,275,493(+) TTAAC(-/AGT)GGTGT cds-indel
rs1063932 -- 72,275,890(+) ACCCC(C/T)CCCCG utr-variant-3-prime
rs11000247 -- 72,273,609(+) CAACC(C/T)TATAA upstream-variant-2KB
rs111443920 -- 72,274,702(+) ACGGC(A/T)TACCT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DDIT4 Gene

Variant ID Type Subtype PubMed ID
esv2761604 CNV loss 21179565
nsv551514 CNV loss 21841781

Variation tolerance for DDIT4 Gene

Residual Variation Intolerance Score: 39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.78; 16.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDIT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDIT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDIT4 Gene

Disorders for DDIT4 Gene

Relevant External Links for DDIT4

Genetic Association Database (GAD)
DDIT4
Human Genome Epidemiology (HuGE) Navigator
DDIT4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDIT4

No disorders were found for DDIT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDIT4 Gene

Publications for DDIT4 Gene

  1. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. (PMID: 15632201) Corradetti M.N. … Guan K.-L. (J. Biol. Chem. 2005) 3 4 22 64
  2. Regulation of mTOR and cell growth in response to energy stress by REDD1. (PMID: 15988001) Sofer A. … Ellisen L.W. (Mol. Cell. Biol. 2005) 3 4 22 64
  3. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. (PMID: 11884613) Shoshani T. … Feinstein E. (Mol. Cell. Biol. 2002) 2 3 4 64
  4. TXNIP potentiates Redd1-induced mTOR suppression through stabilization of Redd1. (PMID: 21460850) Jin H.O. … Park I.C. (Oncogene 2011) 3 4 64
  5. Structural analysis and functional implications of the negative mTORC1 regulator REDD1. (PMID: 20166753) Vega-Rubin-de-Celis S. … Zhang X. (Biochemistry 2010) 3 4 64

Products for DDIT4 Gene

Sources for DDIT4 Gene

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