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DDIT3 Gene

protein-coding GIFtS: 63

GC12M056196

DNA-damage-inducible transcript 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CEBPZ ^²
CHOP ^¹, ², ³
CHOP10 ^¹, ², ⁵
DDIT-3 ^³
GADD153 ^¹, ², ³, ⁵
MGC4154 ^²

Descriptions
C/EBP homologous protein ^²
C/EBP zeta ^²
C/EBP-homologous protein ^³
CCAAT/enhancer-binding protein homologous protein ^²
DNA-damage-inducible transcript 3 ^²
Growth arrest and DNA-damage-inducible protein GADD153 ^³
growth arrest- and DNA damage-inducible ^²

External Ids
HGNC: 2726¹
Entrez Gene: 1649²
UniProtKB: P35638³
Ensembl: ENSG00000175197⁷

Search outside databases for aliases for DDIT3 gene

Previous GC identifers: GC12M059181 GC12M058053 GC12M057627

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DDIT3_HUMAN, P35638

Function: Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot

bind DNA

Gene Wiki entry for DDIT3 (DNA_damage-inducible_transcript_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DDIT3 gene

Entrez Gene cytogenetic band: 12q13.1-q13.2 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.1-q13.2

DDIT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M056196: (about GC identifiers)

Start:	56,196,638 bp from pter
End:	56,200,567 bp from pter
Size:	3,930 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DDIT3_HUMAN, P35638 (See protein sequence)

Recommended Name: DNA damage-inducible transcript 3

Size: 169 amino acids; 19175 Da

Subunit: Heterodimer

Subcellular location: Nucleus

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004074.2

ENSEMBL proteins:

ENSP00000340671

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (GADD153)
	Human Recombinant Proteins from Abnova (DDIT3)

OriGene Purified Recombinant Human Protein: DDIT3

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for DDIT3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for DDIT3
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for DDIT3 (CHOP)
	Antibodies from Abcam (GADD153), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DDIT3)
	Novus Biologicals Antibodies for DDIT3

Assays for DDIT3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35638

ProtoNet protein and cluster: P35638

UniProtKB/Swiss-Prot: DDIT3_HUMAN, P35638

Similarity: Belongs to the bZIP family

Similarity: Contains 1 bZIP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DDIT3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DDIT3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004083

Applied Biosystems Silencer® siRNAs for DDIT3

Sigma-Aldrich siRNA for DDIT3

Sigma-Aldrich shRNA Panels and shRNA for DDIT3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DDIT3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004083
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004083
untagged cDNA clones in CMV expression vector (see all 2): NM_004083

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004083

UniProtKB/Swiss-Prot: DDIT3_HUMAN, P35638

Function: Inhibits the DNA-binding activity of C/EBP and LAP by forming heterodimers that cannot

bind DNA

Genatlas biochemistry entry for DDIT3:

DDIT3 dominant negative regulator of several C/EBP transcription factors,involved in t(12;16)

translocation (see FUS),involved in erythroid growth and differentiation possibly through

interaction with both C/EBP and non C/EBP family members

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ddit3):

cellular

endocrine/exocrine gland

homeostasis/metabolism

immune system

nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	NAS	8510758
GO:0003714	transcription corepressor activity	TAS	7503811
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0046983	protein dimerization activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for DDIT3 (Your Favorite Gene powered by Ingenuity)

p38 MAPK Signaling

GeneDecks DDIT3 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for DDIT3

5/60 Interacting proteins for DDIT3 (P35638² ENSP00000340671³) via UniProtKB, MINT, and/or STRING (see all 60 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BATF	Q16520²	MINT-68453
C10orf119	Q9BTE3²	MINT-67504
CEBPG	P53567²	MINT-68484
HSD17B14	Q9BPX1²	MINT-66282
SPOP	O43791²	MINT-67967

About this table

5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001975	response to amphetamine	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	TAS	7503811
GO:0006974	response to DNA damage stimulus	TAS	1339368
GO:0006979	response to oxidative stress	IEA	--
GO:0006983	ER overload response	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DDIT3
10/26 Novoseek chemical compound relationships for DDIT3 gene (see all 26 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
l-(4,5-3h)leucine	72.55	1	11113529 (1)
pga2	64.23	12	1735464 (6), 7926370 (1)
sp 600125	48.01	6	15466475 (1), 15680548 (1), 18767967 (1), 19139269 (1)
deferoxamine mesylate	45.66	2	14604972 (1)
oxygen	31.66	19	12880976 (1), 16972258 (1), 17695528 (1), 9250393 (1) (see all 14)
asparagine	28.79	3	17276738 (1), 10827209 (1), 12700400 (1)
leucine	28.09	4	8125258 (1), 8510758 (1), 7987849 (1)
amino acid	26.74	5	14630918 (5)
1 methyl 4 phenylpyridinium	24.03	2	14649730 (1), 17631803 (1)
bapta	23.34	3	9365549 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DDIT3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DDIT3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004083

Sigma-Aldrich siRNA for DDIT3

Sigma-Aldrich shRNA Panels and shRNA for DDIT3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004083

REFSEQ mRNAs for DDIT3 gene:

NM_004083.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004083

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004083
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004083
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004083

Additional cDNA sequence:

BT006691.1 CR616853.1

12 DOTS entries:

DT.91780645 DT.100045496 DT.97810576 DT.40306179 DT.95193903 DT.100687083 DT.121187388 DT.91780612

DT.40236699 DT.100687093 DT.121187409 DT.91780636

24/277 AceView cDNA sequences (see all 277 ):

BM823128 CD675012 BM830943 BM669449 BU664440 CB144081 BU664077 AW043601

CN482753 CR616853 BM830819 CD678684 BM823617 R51042 BM759769 BM831039

AA812094 BM977799 BU682572 AA128239 CN482428 BM823190 BQ694049 BU783563

highest scoring ESTs for DDIT3:

AA476561 AJ712787 AJ712803 AV729744 AV751742 AV764496 BC003637 BE295222 BE299745 BE300044

Unigene Clusters for DDIT3:

DNA-damage-inducible transcript 3

Hs.505777 [show with all ESTs], Hs.690217 [show with all ESTs]

Unigene Representative Sequences: BC107859, BE299644

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DDIT3 (see all 8 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	·	3e	·	3f	^	4a	·	4b	·	4c	·	4d	·	4e
SP1:					-				-		-		-		-
SP2:					-				-		-		-
SP3:					-
SP4:					-				-
SP5:					-				-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for DDIT3

1 Ensembl transcript including schematic representation:

ENST00000346473

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DDIT3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DDIT3

¹ / ² / ³

5 probe-sets matching DDIT3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1842_at²^{, 3}	U95-A	2	1.00	0.50	0.91	1.17	HG2724-HT2820	0.20	1.00	0.72	1
39420_at²^{, 3}	U95-A	2	1.00	0.50	0.93	1.15	S62138	0.20	0.33	0.27	2
77662_at*²^{, 3}	U95-E	2	1.00	0.50	0.77	0.69	AI567086	0.60	0.83	0.73	1
209383_at²^{, 3}	U133-A	2	1.00	0.50	--	--	BC003637	0.80	0.88	0.84	1
209383_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.505777 Hs.690217
Expression variation in blood from EXPOLDB for DDIT3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DDIT3 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DDIT3¹	--	DNA-damage-inducible transcript 3	92.46(n) 92.86(a)	607439 XM_844109.1 XP_849202.1
chimpanzee (Pan troglodytes)	DDIT3¹	--	DNA-damage-inducible transcript 3	99.01(n) 99.41(a)	452017 XM_509165.2 XP_509165.2
rat (Rattus norvegicus)	Ddit3¹	--	DNA-damage inducible transcript 3	88.29(n) 89.29(a)	29467 NM_024134.1 NP_077048.1
mouse (Mus musculus)	Ddit3^{1, 5}	10⁵	DNA-damage inducible transcript 3^{1, 5}	87.9(n)¹ 89.29(a)¹	13198¹ NM_007837.2¹ NP_031863.2¹ AK028120⁵ AK040004⁵ (see all 9)

About this table Species with no ortholog for DDIT3

ENSEMBL Gene Tree for DDIT3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/28 NCBI SNPs in DDIT3 are shown (see all 28 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 45)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs28382839^1,2	F	56200531(-)	`CGTATC/TATGTT`	1	--	ut5¹ ese³		5	NS	190
	rs28382838^1,2	F	56200536(-)	`CTGAGC/TGTATC`	1	--	ut5¹ ese³		5	NS	190
	rs28382837^1,2	F	56200577(-)	`CAGCCA/TGGCGC`	1	--	ng3¹ tfbs³		5	NS	190
	rs697221^1,2	A,C,F,H	56197427(+)	`GTCCCG/AAAGGA`	1	F/F	syn¹ trp³		12	NA MN NS EU EA WA	878
--	rs703835^1,2	A,C,F,H	56197735(+)	`TTTGGA/GAAAGG`	1	--	int¹		9	EU EA WA NS	592
--	rs4760298^1,2	A,C,F	56197996(+)	`CTCGGC/TCTCCC`	1	--	int¹		5	NS	184
--	rs703836^1,2	A,C,F	56198823(+)	`cctgcT/Ctcagc`	1	--	int¹		5	NS	178
	rs28382842^1,2	F	56200007(-)	`CCACCT/CTGGTA`	1	--	int¹		5	NS	190
	rs28382841^1,2	F	56200230(-)	`AAAGGG/AACCTC`	1	--	int¹		5	NS	190
--	rs28382844^1,2	F	56198278(-)	`TAAAGAAAG/- TCAGG`	1	--	int¹		5	NS	184

About this table

HapMap Linkage Disequilibrium images for DDIT3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 126337

UniProtKB/Swiss-Prot: DDIT3_HUMAN, P35638

A chromosomal aberration involving DDIT3 is found in a form of malignant myxoid

liposarcoma [MIM:126337]. Translocation t(12;16)(q13;p11) with FUS

10/35 Novoseek disease relationships for DDIT3 gene (see all 35 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
liposarcoma myxoid	91.81	26	18162764 (3), 8143276 (2), 8637704 (2), 8510758 (2) (see all 17)
liposarcoma	79.47	26	11126370 (2), 12168660 (2), 9676855 (1), 12169678 (1) (see all 16)
sarcoma	45.80	8	18162764 (2), 7687873 (2), 8117620 (1), 10448063 (1)
cancer	34.42	22	15322075 (3), 16463383 (2), 12138118 (2), 19276161 (1) (see all 12)
colon cancer	33.27	5	18534616 (1), 15271854 (1), 16434966 (1), 17180111 (1) (see all 5)
tumors	31.63	31	10430059 (4), 10803921 (3), 10534579 (2), 8117620 (2) (see all 20)
lipoma	31.23	1	9244875 (1)
ewings sarcoma	27.58	1	7493135 (1)
myeloma	24.63	7	16572396 (4), 12402318 (1)
malignant fibrous histiocytoma	24.49	1	8143276 (1)

About this table

Genatlas disease: DDIT3

myxoid liposarcoma,with breakpoint in t(12;16) translocation (see FUS)

Genetic Association Database: DDIT3
Human Genome Epidemiology Navigator: DDIT3 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/312 PubMed articles for DDIT3 gene (see all 312 ):

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. (PubMed id 8510758)^{1, 3, 4} Crozat A.... Ron D. (1993)
Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. (PubMed id 1990262)^{1, 2, 3} Papathanasiou M.A.... Fornace A.J. Jr. (1991)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. (PubMed id 7503811)^{3, 4} Rabbitts T.H....Nathan P. (1993)
Isolation, characterization and chromosomal localization of the human GADD153 gene. (PubMed id 1339368)^{3, 4} Park J.S.... Holbrook N.J. (1992)
Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion. (PubMed id 17872950)^{1, 3} Ohoka N....Hayashi H. (2007)
CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation. (PubMed id 12876286)^{1, 3} Ubeda M. and Habener J.F. (2003)
GADD153 is an independent prognostic factor in melanoma: immunohistochemical and molecular genetic analysis. (PubMed id 12168790)^{1, 3} Korabiowska M....Brinck U. (2002)
Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene. (PubMed id 16463383)^{1, 3} Suganuma M....Fujiki H. (2006)
Increased GADD gene expression in human colon epithelial cells exposed to deoxycholate. (PubMed id 15316935)^{1, 3} Scott D.W....Loo G. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1649	HGNC: 2726	AceView: DDIT3	Ensembl:ENSG00000175197	euGenes: HUgn1649
ECgene: DDIT3	H-InvDB: DDIT3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DDIT3	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ddit3/

Licensable Technologies for DDIT3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DDIT3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DDIT3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DDIT3		Antibodies for DDIT3
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DDIT3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (DDIT3)
	Antibodies (DDIT3)
	Chimera RNAi (DDIT3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for DDIT3 (CHOP)

	Recombinant Proteins (GADD153)
	Antibodies (GADD153)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for DDIT3

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for DDIT3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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DDIT3 Gene at Home site.
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DDIT3 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for DDIT3

Summaries
for DDIT3

Genomic Location
for DDIT3

Proteins
for DDIT3

Protein Domains/
Families
for DDIT3

Gene Function
for DDIT3

Pathways & Interactions
for DDIT3

Drugs & Compounds
for DDIT3

Transcripts
for DDIT3

Expression
for DDIT3

Orthologs
for DDIT3

Paralogs
for DDIT3

SNPs/Variants
for DDIT3

Disorders & Mutations
for DDIT3

Medical News
for DDIT3

Publications
for DDIT3

Search for DDIT3

Genome Databases showing DDIT3

Other Databases showing DDIT3

Specialized Databases showing DDIT3

Licensable Technologies
for DDIT3

Services
for DDIT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DDIT3 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor DDIT3

Summariesfor DDIT3

Genomic Locationfor DDIT3

Proteinsfor DDIT3

Protein Domains/Familiesfor DDIT3

Gene Functionfor DDIT3

Pathways & Interactionsfor DDIT3

Drugs & Compoundsfor DDIT3

Transcriptsfor DDIT3

Expression for DDIT3

Orthologsfor DDIT3

Paralogsfor DDIT3

SNPs/Variantsfor DDIT3

Disorders & Mutationsfor DDIT3

Medical Newsfor DDIT3

Publicationsfor DDIT3

Search for DDIT3

Genome Databases showing DDIT3

Other Databases showing DDIT3

Specialized Databases showing DDIT3

Licensable Technologiesfor DDIT3

Servicesfor DDIT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DDIT3

Summaries
for DDIT3

Genomic Location
for DDIT3

Proteins
for DDIT3

Protein Domains/
Families
for DDIT3

Gene Function
for DDIT3

Pathways & Interactions
for DDIT3

Drugs & Compounds
for DDIT3

Transcripts
for DDIT3

Expression
for DDIT3

Orthologs
for DDIT3

Paralogs
for DDIT3

SNPs/Variants
for DDIT3

Disorders & Mutations
for DDIT3

Medical News
for DDIT3

Publications
for DDIT3

Licensable Technologies
for DDIT3

Services
for DDIT3