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Aliases for DDIAS Gene

Aliases for DDIAS Gene

  • DNA Damage Induced Apoptosis Suppressor 2 3 5
  • Nitric Oxide-Inducible Gene Protein 3 4
  • C11orf82 3 4
  • Noxin 3 4
  • DNA Damage-Induced Apoptosis Suppressor Protein 3
  • Chromosome 11 Open Reading Frame 82 2
  • Nitric Oxide-Inducible 2

External Ids for DDIAS Gene

Previous HGNC Symbols for DDIAS Gene

  • C11orf82

Summaries for DDIAS Gene

GeneCards Summary for DDIAS Gene

DDIAS (DNA Damage Induced Apoptosis Suppressor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DDIAS Gene

  • May be an anti-apoptotic protein involved in DNA repair or cell survival.

Additional gene information for DDIAS Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDIAS Gene

Genomics for DDIAS Gene

GeneHancer (GH) Regulatory Elements for DDIAS Gene

Promoters and enhancers for DDIAS Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I082899 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 575.5 +1.0 980 3.8 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B DDIAS PRCP PCF11 ENSG00000254676 ENSG00000254551 ANKRD42 RAB30 RPL7AP54
GH11I082914 Promoter 0.5 EPDnew 550.4 +14.4 14362 0.1 DDIAS RAB30-AS1 RAB30 RPL7AP54 PRCP
GH11I082863 Enhancer 1.2 Ensembl ENCODE dbSUPER 28.7 -35.5 -35521 1.2 RAD21 ZBTB40 RFX5 DEK RXRA USF2 CEBPB REST NR2F2 KAT8 DDIAS FAM181B PRCP ENSG00000254441
GH11I082888 Enhancer 1.1 Ensembl ENCODE dbSUPER 23 -9.4 -9415 3.3 HDGF MEIS2 PKNOX1 MTA2 JUN HLF TAL1 CBFA2T3 ZBTB40 MTA1 DDIAS PRCP RAB30 RAB30-AS1 ENSG00000254441
GH11I083033 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 14.2 +135.1 135060 3.8 NFIB RFX5 ZSCAN5C RCOR1 RUNX3 CEBPB SMARCB1 PPARG NR2F2 NFIC RAB30 DDIAS RAB30-AS1 PRCP ENSG00000254698 GC11M082975
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DDIAS on UCSC Golden Path with GeneCards custom track

Genomic Locations for DDIAS Gene

Genomic Locations for DDIAS Gene
chr11:82,899,975-82,958,277
(GRCh38/hg38)
Size:
58,303 bases
Orientation:
Plus strand
chr11:82,611,017-82,669,319
(GRCh37/hg19)

Genomic View for DDIAS Gene

Genes around DDIAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDIAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDIAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDIAS Gene

Proteins for DDIAS Gene

  • Protein details for DDIAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXT1-DDIAS_HUMAN
    Recommended name:
    DNA damage-induced apoptosis suppressor protein
    Protein Accession:
    Q8IXT1
    Secondary Accessions:
    • Q96LK6
    • Q9H856

    Protein attributes for DDIAS Gene

    Size:
    998 amino acids
    Molecular mass:
    111616 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DDIAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDIAS Gene

Post-translational modifications for DDIAS Gene

No Post-translational modifications

No data available for DME Specific Peptides for DDIAS Gene

Domains & Families for DDIAS Gene

Gene Families for DDIAS Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for DDIAS Gene

Suggested Antigen Peptide Sequences for DDIAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DDIAS: view

No data available for UniProtKB/Swiss-Prot for DDIAS Gene

Function for DDIAS Gene

Molecular function for DDIAS Gene

UniProtKB/Swiss-Prot Function:
May be an anti-apoptotic protein involved in DNA repair or cell survival.
UniProtKB/Swiss-Prot Induction:
Induced by UV irradiation. Expression starts to increase in early S phase and is steady high until late S phase in both cancer and normal cells.

Phenotypes From GWAS Catalog for DDIAS Gene

Gene Ontology (GO) - Molecular Function for DDIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DDIAS: view
genes like me logo Genes that share phenotypes with DDIAS: view

miRNA for DDIAS Gene

miRTarBase miRNAs that target DDIAS

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDIAS Gene

Localization for DDIAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDIAS Gene

Cytoplasm. Nucleus. Note=Accumulates in the nucleus in response to stress. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDIAS gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DDIAS: view

Pathways & Interactions for DDIAS Gene

SuperPathways for DDIAS Gene

No Data Available

Interacting Proteins for DDIAS Gene

Selected Interacting proteins: Q8IXT1-DDIAS_HUMAN for DDIAS Gene via IID

Symbol External ID(s) Details
SMC2
VCP

Gene Ontology (GO) - Biological Process for DDIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IEA --
GO:0097752 regulation of DNA stability IMP 24214091
GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP 24214091
genes like me logo Genes that share ontologies with DDIAS: view

No data available for Pathways by source and SIGNOR curated interactions for DDIAS Gene

Drugs & Compounds for DDIAS Gene

No Compound Related Data Available

Transcripts for DDIAS Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDIAS Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - -
SP3: - - - -
SP4:
SP5: - - - - - -
SP6: - -

Relevant External Links for DDIAS Gene

GeneLoc Exon Structure for
DDIAS
ECgene alternative splicing isoforms for
DDIAS

Expression for DDIAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDIAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDIAS Gene

This gene is overexpressed in Plasma (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DDIAS Gene



Protein tissue co-expression partners for DDIAS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDIAS Gene:

DDIAS

mRNA Expression by UniProt/SwissProt for DDIAS Gene:

Q8IXT1-DDIAS_HUMAN
Tissue specificity: Highly expressed in colorectal and lung cancer tissues.

Evidence on tissue expression from TISSUES for DDIAS Gene

  • Heart(5)
  • Liver(2.9)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with DDIAS: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDIAS Gene

Orthologs for DDIAS Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDIAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf82 33
  • 99.2 (n)
C11orf82 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C21H11orf82 33
  • 83.46 (n)
C11orf82 34
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C29H11orf82 33
  • 81.31 (n)
C11orf82 34
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4632434I11Rik 34 33
  • 73.55 (n)
OneToOne
Ddias 16
rat
(Rattus norvegicus)
Mammalia RGD1559690 33
  • 73.52 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf82 34
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf82 34
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H11orf82 33
  • 50.95 (n)
C11orf82 34
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf82 34
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C21H11orf82 34
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToOne
Species where no ortholog for DDIAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDIAS Gene

ENSEMBL:
Gene Tree for DDIAS (if available)
TreeFam:
Gene Tree for DDIAS (if available)

Paralogs for DDIAS Gene

No data available for Paralogs for DDIAS Gene

Variants for DDIAS Gene

Sequence variations from dbSNP and Humsavar for DDIAS Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000024943 -- 82,907,612(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000311161 -- 82,921,835(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000357582 -- 82,913,336(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000386511 -- 82,921,576(+) T/C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000468462 -- 82,906,182(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDIAS Gene

Variant ID Type Subtype PubMed ID
dgv2038n54 CNV loss 21841781
esv2744837 CNV deletion 23290073
esv33531 CNV loss 17666407
esv3579916 CNV gain 25503493
nsv515868 CNV gain 19592680
nsv555602 CNV gain 21841781

Variation tolerance for DDIAS Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDIAS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDIAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDIAS Gene

Disorders for DDIAS Gene

Additional Disease Information for DDIAS

No disorders were found for DDIAS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDIAS Gene

Publications for DDIAS Gene

  1. Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma. (PMID: 24214091) Won KJ … Won M (International journal of cancer 2014) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells. (PMID: 28079882) Won KJ … Won M (Cell death & disease 2017) 3 58
  5. Noxin promotes proliferation of breast cancer cells via P38-ATF2 signaling pathway. (PMID: 28618963) Zhang X … Miao Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 58

Products for DDIAS Gene

Sources for DDIAS Gene

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