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Aliases for DDIAS Gene

Aliases for DDIAS Gene

  • DNA Damage-Induced Apoptosis Suppressor 2 3
  • Nitric Oxide-Inducible Gene Protein 3 4
  • C11orf82 3 4
  • Noxin 3 4
  • DNA Damage-Induced Apoptosis Suppressor Protein 3
  • Chromosome 11 Open Reading Frame 82 2
  • Nitric Oxide-Inducible 2

External Ids for DDIAS Gene

Previous HGNC Symbols for DDIAS Gene

  • C11orf82

Summaries for DDIAS Gene

GeneCards Summary for DDIAS Gene

DDIAS (DNA Damage-Induced Apoptosis Suppressor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DDIAS Gene

  • May be an anti-apoptotic protein involved in DNA repair or cell survival.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDIAS Gene

Genomics for DDIAS Gene

Genomic Location for DDIAS Gene

82,899,975 bp from pter
82,958,277 bp from pter
58,303 bases
Plus strand

Genomic View for DDIAS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDIAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDIAS Gene

No data available for Regulatory Elements for DDIAS Gene

Proteins for DDIAS Gene

  • Protein details for DDIAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA damage-induced apoptosis suppressor protein
    Protein Accession:
    Secondary Accessions:
    • Q96LK6
    • Q9H856

    Protein attributes for DDIAS Gene

    998 amino acids
    Molecular mass:
    111616 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DDIAS Gene


neXtProt entry for DDIAS Gene

Proteomics data for DDIAS Gene at MOPED

Post-translational modifications for DDIAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDIAS Gene

Domains for DDIAS Gene

Protein Domains for DDIAS Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DDIAS: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for DDIAS Gene

Function for DDIAS Gene

Molecular function for DDIAS Gene

UniProtKB/Swiss-Prot Function:
May be an anti-apoptotic protein involved in DNA repair or cell survival.
UniProtKB/Swiss-Prot Induction:
Induced by UV irradiation. Expression starts to increase in early S phase and is steady high until late S phase in both cancer and normal cells.

Phenotypes for DDIAS Gene

GenomeRNAi human phenotypes for DDIAS:
genes like me logo Genes that share phenotypes with DDIAS: view

miRNA for DDIAS Gene

miRTarBase miRNAs that target DDIAS

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDIAS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for DDIAS Gene

Localization for DDIAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDIAS Gene

Cytoplasm. Nucleus. Note=Accumulates in the nucleus in response to stress. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for DDIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DDIAS: view

No data available for Subcellular locations from COMPARTMENTS for DDIAS Gene

Pathways for DDIAS Gene

SuperPathways for DDIAS Gene

No Data Available

Interacting Proteins for DDIAS Gene

Gene Ontology (GO) - Biological Process for DDIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007286 spermatid development IEA --
GO:0030097 hemopoiesis IEA --
GO:0034644 cellular response to UV IEA --
genes like me logo Genes that share ontologies with DDIAS: view

No data available for Pathways by source for DDIAS Gene

Transcripts for DDIAS Gene

Alternative Splicing Database (ASD) splice patterns (SP) for DDIAS Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - -
SP3: - - - -
SP5: - - - - - -
SP6: - -

Relevant External Links for DDIAS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDIAS Gene

mRNA expression in normal human tissues for DDIAS Gene

Protein differential expression in normal tissues for DDIAS Gene

This gene is overexpressed in Plasma (68.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DDIAS Gene

mRNA Expression by UniProt/SwissProt for DDIAS Gene

Tissue specificity: Highly expressed in colorectal and lung cancer tissues.
genes like me logo Genes that share expressions with DDIAS: view

Expression partners for DDIAS Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DDIAS Gene

Orthologs for DDIAS Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDIAS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C29H11orf82 35
  • 81.31 (n)
  • 69.01 (a)
C11orf82 36
  • 69 (a)
(Canis familiaris)
Mammalia C21H11orf82 35
  • 83.46 (n)
  • 70.16 (a)
C11orf82 36
  • 70 (a)
(Mus musculus)
Mammalia 4632434I11Rik 35
  • 73.55 (n)
  • 55.19 (a)
4632434I11Rik 16
4632434I11Rik 36
  • 54 (a)
(Pan troglodytes)
Mammalia C11H11orf82 35
  • 99.2 (n)
  • 98.1 (a)
C11orf82 36
  • 98 (a)
(Rattus norvegicus)
Mammalia RGD1559690 35
  • 73.52 (n)
  • 57.47 (a)
(Monodelphis domestica)
Mammalia C11orf82 36
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf82 36
  • 30 (a)
(Gallus gallus)
Aves C1H11orf82 35
  • 50.95 (n)
  • 36.58 (a)
C11orf82 36
  • 36 (a)
(Anolis carolinensis)
Reptilia C11orf82 36
  • 58 (a)
(Danio rerio)
Actinopterygii C21H11orf82 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for DDIAS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDIAS Gene

Gene Tree for DDIAS (if available)
Gene Tree for DDIAS (if available)

Paralogs for DDIAS Gene

No data available for Paralogs for DDIAS Gene

Variants for DDIAS Gene

Sequence variations from dbSNP and Humsavar for DDIAS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs610862 -- 82,924,764(+) gagcc(A/C)agatc intron-variant
rs611225 -- 82,924,797(-) tgctt(G/T)gttgc intron-variant
rs627570 -- 82,913,966(+) agttt(G/T)gctct intron-variant
rs646981 -- 82,919,803(-) agtgc(A/G)ctgag intron-variant
rs657014 -- 82,924,815(+) gtctc(A/C)aaaaa intron-variant

Relevant External Links for DDIAS Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DDIAS Gene

Disorders for DDIAS Gene

No disorders were found for DDIAS Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DDIAS Gene

Publications for DDIAS Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma. (PMID: 24214091) Won K.J. … Won M. (Int. J. Cancer 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for DDIAS Gene

Sources for DDIAS Gene

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