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Aliases for DDIAS Gene

Aliases for DDIAS Gene

  • DNA Damage Induced Apoptosis Suppressor 2 3 5
  • Nitric Oxide-Inducible Gene Protein 3 4
  • C11orf82 3 4
  • Noxin 3 4
  • DNA Damage-Induced Apoptosis Suppressor Protein 3
  • Chromosome 11 Open Reading Frame 82 2
  • Nitric Oxide-Inducible 2

External Ids for DDIAS Gene

Previous HGNC Symbols for DDIAS Gene

  • C11orf82

Summaries for DDIAS Gene

GeneCards Summary for DDIAS Gene

DDIAS (DNA Damage Induced Apoptosis Suppressor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DDIAS Gene

  • May be an anti-apoptotic protein involved in DNA repair or cell survival.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDIAS Gene

Genomics for DDIAS Gene

Regulatory Elements for DDIAS Gene

Enhancers for DDIAS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G082899 1.7 FANTOM5 ENCODE dbSUPER 25.4 +1.0 981 3.8 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 DDIAS PRCP PCF11 ENSG00000254676 ANKRD42 RAB30 RPL7AP54
GH11G082863 1.3 Ensembl ENCODE dbSUPER 28.6 -35.5 -35522 1.2 CTCF ESRRA MAX CEBPG ZBTB40 RAD21 RFX5 GATA3 GATA2 SMC3 DDIAS FAM181B PRCP ENSG00000254441
GH11G082888 1.2 Ensembl ENCODE dbSUPER 23 -9.4 -9416 3.3 HDGF PKNOX1 TAL1 JUN ZBTB40 GATA2 ETV6 L3MBTL2 MTA2 HLF DDIAS PRCP RAB30 RAB30-AS1 ENSG00000254441
GH11G082959 1.3 Ensembl ENCODE dbSUPER 20.7 +60.5 60517 2.1 PKNOX1 FEZF1 ZIC2 ARID3A CBX5 ETV6 RELB IKZF2 CREM MTA2 DDIAS RAB30-AS1 RAB30 ENSG00000254698 SNORA70E ENSG00000254522 PRCP ENSG00000242279
GH11G082971 1.4 Ensembl ENCODE dbSUPER 16.8 +71.9 71915 1.2 TBP PKNOX1 BMI1 ZNF2 RAD21 ZNF366 CBX5 ZNF143 RELB ETV6 DDIAS RAB30-AS1 PRCP GC11M082975
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDIAS on UCSC Golden Path with GeneCards custom track

Promoters for DDIAS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042748 925 3001 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for DDIAS Gene

Chromosome:
11
Start:
82,899,975 bp from pter
End:
82,958,277 bp from pter
Size:
58,303 bases
Orientation:
Plus strand

Genomic View for DDIAS Gene

Genes around DDIAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDIAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDIAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDIAS Gene

Proteins for DDIAS Gene

  • Protein details for DDIAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXT1-DDIAS_HUMAN
    Recommended name:
    DNA damage-induced apoptosis suppressor protein
    Protein Accession:
    Q8IXT1
    Secondary Accessions:
    • Q96LK6
    • Q9H856

    Protein attributes for DDIAS Gene

    Size:
    998 amino acids
    Molecular mass:
    111616 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DDIAS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDIAS Gene

Post-translational modifications for DDIAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDIAS Gene

Domains & Families for DDIAS Gene

Protein Domains for DDIAS Gene

Suggested Antigen Peptide Sequences for DDIAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DDIAS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DDIAS Gene

Function for DDIAS Gene

Molecular function for DDIAS Gene

UniProtKB/Swiss-Prot Function:
May be an anti-apoptotic protein involved in DNA repair or cell survival.
UniProtKB/Swiss-Prot Induction:
Induced by UV irradiation. Expression starts to increase in early S phase and is steady high until late S phase in both cancer and normal cells.
genes like me logo Genes that share phenotypes with DDIAS: view

Animal Model Products

CRISPR Products

miRNA for DDIAS Gene

miRTarBase miRNAs that target DDIAS

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDIAS Gene

Localization for DDIAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDIAS Gene

Cytoplasm. Nucleus. Note=Accumulates in the nucleus in response to stress. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDIAS gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DDIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DDIAS: view

Pathways & Interactions for DDIAS Gene

SuperPathways for DDIAS Gene

No Data Available

Interacting Proteins for DDIAS Gene

Selected Interacting proteins: Q8IXT1-DDIAS_HUMAN for DDIAS Gene via IID

Symbol External ID(s) Details
SMC2
VCP

Gene Ontology (GO) - Biological Process for DDIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IEA --
genes like me logo Genes that share ontologies with DDIAS: view

No data available for Pathways by source and SIGNOR curated interactions for DDIAS Gene

Drugs & Compounds for DDIAS Gene

No Compound Related Data Available

Transcripts for DDIAS Gene

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDIAS Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - -
SP3: - - - -
SP4:
SP5: - - - - - -
SP6: - -

Relevant External Links for DDIAS Gene

GeneLoc Exon Structure for
DDIAS
ECgene alternative splicing isoforms for
DDIAS

Expression for DDIAS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDIAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDIAS Gene

This gene is overexpressed in Plasma (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DDIAS Gene



Protein tissue co-expression partners for DDIAS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDIAS Gene:

DDIAS

mRNA Expression by UniProt/SwissProt for DDIAS Gene:

Q8IXT1-DDIAS_HUMAN
Tissue specificity: Highly expressed in colorectal and lung cancer tissues.

Evidence on tissue expression from TISSUES for DDIAS Gene

  • Heart(5)
  • Liver(2.9)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with DDIAS: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDIAS Gene

Orthologs for DDIAS Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDIAS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf82 34
  • 99.2 (n)
C11orf82 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C21H11orf82 34
  • 83.46 (n)
C11orf82 35
  • 70 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C29H11orf82 34
  • 81.31 (n)
C11orf82 35
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4632434I11Rik 34 35
  • 73.55 (n)
Ddias 16
rat
(Rattus norvegicus)
Mammalia RGD1559690 34
  • 73.52 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf82 35
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf82 35
  • 30 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H11orf82 34
  • 50.95 (n)
C11orf82 35
  • 36 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf82 35
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C21H11orf82 35
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToOne
Species where no ortholog for DDIAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDIAS Gene

ENSEMBL:
Gene Tree for DDIAS (if available)
TreeFam:
Gene Tree for DDIAS (if available)

Paralogs for DDIAS Gene

No data available for Paralogs for DDIAS Gene

Variants for DDIAS Gene

Sequence variations from dbSNP and Humsavar for DDIAS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000024943 -- 82,907,612(+) ACCGC(A/G)CACTG intron-variant
rs1000311161 -- 82,921,835(+) CAGCC(C/T)CCCAA intron-variant, upstream-variant-2KB
rs1000357582 -- 82,913,336(+) AGCTC(A/G)CTATG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000386511 -- 82,921,576(+) CTTTT(G/T)TTTTT intron-variant, upstream-variant-2KB
rs1000468462 -- 82,906,182(+) TAACA(A/G)TAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDIAS Gene

Variant ID Type Subtype PubMed ID
dgv2038n54 CNV loss 21841781
esv2744837 CNV deletion 23290073
esv33531 CNV loss 17666407
esv3579916 CNV gain 25503493
nsv515868 CNV gain 19592680
nsv555602 CNV gain 21841781

Variation tolerance for DDIAS Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDIAS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDIAS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDIAS Gene

Disorders for DDIAS Gene

Relevant External Links for DDIAS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDIAS

No disorders were found for DDIAS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDIAS Gene

Publications for DDIAS Gene

  1. Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma. (PMID: 24214091) Won K.J. … Won M. (Int. J. Cancer 2013) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Stability of the cancer target DDIAS is regulated by the CHIP/HSP70 pathway in lung cancer cells. (PMID: 28079882) Won K.J. … Won M. (Cell Death Dis 2017) 3 64
  5. DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer. (PMID: 26493727) Im J.Y. … Won M. (Biochim. Biophys. Acta 2016) 3 64

Products for DDIAS Gene

Sources for DDIAS Gene

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