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Aliases for DDIAS Gene

Aliases for DDIAS Gene

  • DNA Damage Induced Apoptosis Suppressor 2 3 5
  • Nitric Oxide-Inducible Gene Protein 3 4
  • C11orf82 3 4
  • Noxin 3 4
  • DNA Damage-Induced Apoptosis Suppressor Protein 3
  • Chromosome 11 Open Reading Frame 82 2
  • Nitric Oxide-Inducible 2

External Ids for DDIAS Gene

Previous HGNC Symbols for DDIAS Gene

  • C11orf82

Summaries for DDIAS Gene

GeneCards Summary for DDIAS Gene

DDIAS (DNA Damage Induced Apoptosis Suppressor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DDIAS Gene

  • May be an anti-apoptotic protein involved in DNA repair or cell survival.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDIAS Gene

Genomics for DDIAS Gene

Regulatory Elements for DDIAS Gene

Enhancers for DDIAS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DDIAS on UCSC Golden Path with GeneCards custom track

Promoters for DDIAS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DDIAS Gene

82,899,975 bp from pter
82,958,277 bp from pter
58,303 bases
Plus strand

Genomic View for DDIAS Gene

Genes around DDIAS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDIAS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDIAS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDIAS Gene

Proteins for DDIAS Gene

  • Protein details for DDIAS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DNA damage-induced apoptosis suppressor protein
    Protein Accession:
    Secondary Accessions:
    • Q96LK6
    • Q9H856

    Protein attributes for DDIAS Gene

    998 amino acids
    Molecular mass:
    111616 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14764.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DDIAS Gene


neXtProt entry for DDIAS Gene

Post-translational modifications for DDIAS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DDIAS Gene

Domains & Families for DDIAS Gene

Protein Domains for DDIAS Gene


Suggested Antigen Peptide Sequences for DDIAS Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DDIAS: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DDIAS Gene

Function for DDIAS Gene

Molecular function for DDIAS Gene

UniProtKB/Swiss-Prot Function:
May be an anti-apoptotic protein involved in DNA repair or cell survival.
UniProtKB/Swiss-Prot Induction:
Induced by UV irradiation. Expression starts to increase in early S phase and is steady high until late S phase in both cancer and normal cells.
genes like me logo Genes that share phenotypes with DDIAS: view

Animal Model Products

miRNA for DDIAS Gene

miRTarBase miRNAs that target DDIAS

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDIAS Gene

Localization for DDIAS Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDIAS Gene

Cytoplasm. Nucleus. Note=Accumulates in the nucleus in response to stress. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for DDIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DDIAS: view

No data available for Subcellular locations from COMPARTMENTS for DDIAS Gene

Pathways & Interactions for DDIAS Gene

SuperPathways for DDIAS Gene

No Data Available

Interacting Proteins for DDIAS Gene

Selected Interacting proteins: Q8IXT1-DDIAS_HUMAN for DDIAS Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for DDIAS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007050 cell cycle arrest IEA --
genes like me logo Genes that share ontologies with DDIAS: view

No data available for Pathways by source and SIGNOR curated interactions for DDIAS Gene

Drugs & Compounds for DDIAS Gene

No Compound Related Data Available

Transcripts for DDIAS Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDIAS Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - -
SP2: - -
SP3: - - - -
SP5: - - - - - -
SP6: - -

Relevant External Links for DDIAS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDIAS Gene

mRNA expression in normal human tissues for DDIAS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDIAS Gene

This gene is overexpressed in Plasma (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DDIAS Gene

Protein tissue co-expression partners for DDIAS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDIAS Gene:


mRNA Expression by UniProt/SwissProt for DDIAS Gene:

Tissue specificity: Highly expressed in colorectal and lung cancer tissues.
genes like me logo Genes that share expression patterns with DDIAS: view

Primer Products

No data available for mRNA differential expression in normal tissues for DDIAS Gene

Orthologs for DDIAS Gene

This gene was present in the common ancestor of chordates.

Orthologs for DDIAS Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C29H11orf82 34
  • 81.31 (n)
  • 69.01 (a)
C11orf82 35
  • 69 (a)
(Canis familiaris)
Mammalia C21H11orf82 34
  • 83.46 (n)
  • 70.16 (a)
C11orf82 35
  • 70 (a)
(Mus musculus)
Mammalia 4632434I11Rik 34
  • 73.55 (n)
  • 55.19 (a)
Ddias 16
4632434I11Rik 35
  • 54 (a)
(Rattus norvegicus)
Mammalia RGD1559690 34
  • 73.52 (n)
  • 57.47 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf82 35
  • 30 (a)
(Monodelphis domestica)
Mammalia C11orf82 35
  • 40 (a)
(Pan troglodytes)
Mammalia C11orf82 35
  • 98 (a)
C11H11orf82 34
  • 99.2 (n)
  • 98.1 (a)
(Gallus gallus)
Aves C1H11orf82 34
  • 50.95 (n)
  • 36.58 (a)
C11orf82 35
  • 36 (a)
(Anolis carolinensis)
Reptilia C11orf82 35
  • 58 (a)
(Danio rerio)
Actinopterygii C21H11orf82 35
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for DDIAS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDIAS Gene

Gene Tree for DDIAS (if available)
Gene Tree for DDIAS (if available)

Paralogs for DDIAS Gene

No data available for Paralogs for DDIAS Gene

Variants for DDIAS Gene

Sequence variations from dbSNP and Humsavar for DDIAS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17853911 - 82,931,988(+) CAGCA(C/T)ATATA reference, missense, utr-variant-5-prime
rs7947780 - 82,932,718(+) AGCAG(G/T)TTATC reference, missense
rs35711622 - 82,933,607(+) AATCA(A/G)ATTCA reference, missense
rs11826199 - 82,933,722(+) AAAAC(C/G)TGTAT reference, missense
rs7130899 - 82,933,862(+) CTGGT(A/G)TTTCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DDIAS Gene

Variant ID Type Subtype PubMed ID
dgv2038n54 CNV loss 21841781
esv2744837 CNV deletion 23290073
esv33531 CNV loss 17666407
esv3579916 CNV gain 25503493
nsv515868 CNV gain 19592680
nsv555602 CNV gain 21841781

Variation tolerance for DDIAS Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDIAS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDIAS Gene

Disorders for DDIAS Gene

Relevant External Links for DDIAS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDIAS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDIAS Gene

Publications for DDIAS Gene

  1. Human Noxin is an anti-apoptotic protein in response to DNA damage of A549 non-small cell lung carcinoma. (PMID: 24214091) Won K.J. … Won M. (Int. J. Cancer 2013) 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. DNA damage-induced apoptosis suppressor (DDIAS), a novel target of NFATc1, is associated with cisplatin resistance in lung cancer. (PMID: 26493727) Im J.Y. … Won M. (Biochim. Biophys. Acta 2016) 3 65
  5. NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma. (PMID: 25612832) Zhang Z.Z. … Han Z.G. (Int. J. Cancer 2015) 3 65

Products for DDIAS Gene

Sources for DDIAS Gene

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