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Aliases for DDI2 Gene

Aliases for DDI2 Gene

  • DNA-Damage Inducible 1 Homolog 2 (S. Cerevisiae) 2 3
  • DDI1, DNA-Damage Inducible 1, Homolog 2 (S. Cerevisiae) 2

External Ids for DDI2 Gene

Previous GeneCards Identifiers for DDI2 Gene

  • GC01P015211
  • GC01P015306
  • GC01P015689
  • GC01P015816
  • GC01P015943
  • GC01P014463

Summaries for DDI2 Gene

GeneCards Summary for DDI2 Gene

DDI2 (DNA-Damage Inducible 1 Homolog 2 (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is DDI1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDI2 Gene

Genomics for DDI2 Gene

Regulatory Elements for DDI2 Gene

Genomic Location for DDI2 Gene

Start:
15,617,458 bp from pter
End:
15,669,044 bp from pter
Size:
51,587 bases
Orientation:
Plus strand

Genomic View for DDI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDI2 Gene

Proteins for DDI2 Gene

  • Protein details for DDI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TDH0-DDI2_HUMAN
    Recommended name:
    Protein DDI1 homolog 2
    Protein Accession:
    Q5TDH0
    Secondary Accessions:
    • A8KAE1
    • Q7RTZ0
    • Q9BRT1

    Protein attributes for DDI2 Gene

    Size:
    399 amino acids
    Molecular mass:
    44523 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DDI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDI2 Gene

Proteomics data for DDI2 Gene at MOPED

Post-translational modifications for DDI2 Gene

  • Ubiquitination at Lys67, Lys77, Lys153, Lys170, Lys283, Lys289, Lys338, and Lys389
  • Modification sites at PhosphoSitePlus

Other Protein References for DDI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDI2 Gene

Domains for DDI2 Gene

Suggested Antigen Peptide Sequences for DDI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TDH0

UniProtKB/Swiss-Prot:

DDI2_HUMAN :
  • Q5TDH0
Domain:
  • Contains 1 ubiquitin-like domain.
Family:
  • Belongs to the DDI1 family.
genes like me logo Genes that share domains with DDI2: view

No data available for Gene Families for DDI2 Gene

Function for DDI2 Gene

Gene Ontology (GO) - Molecular Function for DDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DDI2: view

Animal Model Products

CRISPR Products

miRNA for DDI2 Gene

miRTarBase miRNAs that target DDI2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DDI2 Gene

Localization for DDI2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDI2 Gene COMPARTMENTS Subcellular localization image for DDI2 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with DDI2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDI2 Gene

Pathways for DDI2 Gene

SuperPathways for DDI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with DDI2: view

No data available for Pathways by source for DDI2 Gene

Transcripts for DDI2 Gene

Unigene Clusters for DDI2 Gene

DNA-damage inducible 1 homolog 2 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDI2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DDI2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDI2 Gene

No ASD Table

Relevant External Links for DDI2 Gene

GeneLoc Exon Structure for
DDI2
ECgene alternative splicing isoforms for
DDI2

Expression for DDI2 Gene

mRNA expression in normal human tissues for DDI2 Gene

mRNA differential expression in normal tissues according to GTEx for DDI2 Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDI2 Gene

SOURCE GeneReport for Unigene cluster for DDI2 Gene Hs.718857

genes like me logo Genes that share expressions with DDI2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DDI2 Gene

Orthologs for DDI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDI2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDI2 35
  • 99.67 (n)
  • 100 (a)
DDI2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDI2 35
  • 93.01 (n)
  • 96.21 (a)
DDI2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDI2 35
  • 94.78 (n)
  • 96.97 (a)
DDI2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddi2 35
  • 89.22 (n)
  • 95.99 (a)
Ddi2 16
Ddi2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDI2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDI2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddi2 35
  • 88.33 (n)
  • 94.61 (a)
chicken
(Gallus gallus)
Aves DDI2 35
  • 80.69 (n)
  • 89.92 (a)
DDI2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDI2 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53726 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ddi2 35
  • 75.89 (n)
  • 86.29 (a)
zebrafish
(Danio rerio)
Actinopterygii ddi2 35
  • 72.15 (n)
  • 81.27 (a)
ddi2 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rngo 35
  • 55.37 (n)
  • 53.06 (a)
rngo 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C01G5.6 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DDI1 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G13235 35
  • 50.11 (n)
  • 41.99 (a)
rice
(Oryza sativa)
Liliopsida Os02g0198600 35
  • 50.59 (n)
  • 42.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9928 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9741 36
  • 42 (a)
OneToMany
Species with no ortholog for DDI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDI2 Gene

ENSEMBL:
Gene Tree for DDI2 (if available)
TreeFam:
Gene Tree for DDI2 (if available)

Paralogs for DDI2 Gene

Paralogs for DDI2 Gene

Selected SIMAP similar genes for DDI2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DDI2 Gene

genes like me logo Genes that share paralogs with DDI2: view

Variants for DDI2 Gene

Sequence variations from dbSNP and Humsavar for DDI2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs941686 -- 15,656,806(-) GCTAG(C/T)TGTAA intron-variant
rs1122386 -- 15,620,382(+) CATCA(C/T)TATAG intron-variant
rs1122387 -- 15,620,787(+) TAATA(C/T)GTTAT intron-variant
rs1980607 -- 15,648,742(+) AAAGC(A/G)AATTC intron-variant
rs2104038 -- 15,649,492(+) ATGGC(A/G)AAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDI2 Gene

Variant ID Type Subtype PubMed ID
esv259731 OTHER Complex 20981092

Relevant External Links for DDI2 Gene

HapMap Linkage Disequilibrium report
DDI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDI2 Gene

Disorders for DDI2 Gene

Relevant External Links for DDI2

Genetic Association Database (GAD)
DDI2
Human Genome Epidemiology (HuGE) Navigator
DDI2
genes like me logo Genes that share disorders with DDI2: view

No data available for UniProtKB/Swiss-Prot for DDI2 Gene

Publications for DDI2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente X.S. … Lopez-Otin C. (Nat. Rev. Genet. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  5. Affinity purification strategy to capture human endogenous proteasome complexes diversity and to identify proteasome-interacting proteins. (PMID: 19193609) Bousquet-Dubouch M.P. … Monsarrat B. (Mol. Cell Proteomics 2009) 3

Products for DDI2 Gene

Sources for DDI2 Gene

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