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DDI2 Gene

protein-coding   GIFtS: 46
GCID: GC01P015943

DNA-Damage Inducible 1 Homolog 2 (S. Cerevisiae)

(Previous names: DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae))
  Search for DDI2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DNA-Damage Inducible 1 Homolog 2 (S. Cerevisiae)1 2
DDI1, DNA-Damage Inducible 1, Homolog 2 (S. Cerevisiae)1
DDI1, DNA-Damage Inducible 1, Homolog 22
DNA-Damage Inducible Protein 2 (DDI2)2
Protein DDI1 Homolog 22

External Ids:    HGNC: 245781   Entrez Gene: 843012   Ensembl: ENSG000001973127   UniProtKB: Q5TDH03   

Export aliases for DDI2 gene to outside databases

Previous GC identifers: GC01P015211 GC01P015306 GC01P015689 GC01P015816 GC01P014463


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DDI2 Gene:
DDI2 (DNA-damage inducible 1 homolog 2 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is DDI1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DDI2 gene promoter:
         Bach1   AML1a   FOXD1   E2F-2   E4BP4   S8   E2F   E2F-1   SEF-1 (1)   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDI2 promoter sequence
   Search Chromatin IP Primers for DDI2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDI2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.13

DDI2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDI2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P015943:  view genomic region     (about GC identifiers)

Start:
15,943,953 bp from pter      End:
15,995,539 bp from pter
Size:
51,587 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDI2_HUMAN, Q5TDH0 (See protein sequence)
Recommended Name: Protein DDI1 homolog 2  
Size: 399 amino acids; 44523 Da
Secondary accessions: A8KAE1 Q7RTZ0 Q9BRT1
Alternative splicing: 3 isoforms:  Q5TDH0-1   Q5TDH0-2   Q5TDH0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DDI2: NX_Q5TDH0

Explore proteomics data for DDI2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys67, Lys77, Lys153, Lys170, Lys283, Lys289, Lys338, Lys389
  • Modification sites at PhosphoSitePlus

  • See DDI2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115717.3  
    ENSEMBL proteins: 
     ENSP00000417748   ENSP00000449475   ENSP00000448878  

    DDI2 Human Recombinant Protein Products:

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    OriGene MassSpec for DDI2
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    Novus Biologicals DDI2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDI2

     
    Search eBioscience for Proteins for DDI2 

    DDI2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for DDI2
    Cloud-Clone Corp. Antibodies for DDI2
    ThermoFisher Antibodies for DDI2
    LSBio Antibodies in human, mouse, rat for DDI2

    DDI2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDI2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDI2
    Cloud-Clone Corp. CLIAs for DDI2
    Search eBioscience for ELISAs for DDI2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR021109 Peptidase_aspartic_dom
     IPR019103 Peptidase_aspartic_DDI1-type
     IPR000626 Ubiquitin_dom

    Graphical View of Domain Structure for InterPro Entry Q5TDH0

    ProtoNet protein and cluster: Q5TDH0

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: DDI2_HUMAN, Q5TDH0
    Similarity: Belongs to the DDI1 family
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with DDI2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004190aspartic-type endopeptidase activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with DDI2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDI2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDI2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDI2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDI2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDI2:
    hsa-mir-484 (MIRT042045), hsa-mir-7-5p (MIRT047754)

    Block miRNA regulation of human, mouse, rat DDI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDI2 (see all 19):
    hsa-miR-362-3p hsa-let-7d hsa-miR-330-5p hsa-miR-202 hsa-let-7c hsa-miR-766 hsa-miR-4267 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidDDI2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDI2
    Predesigned siRNA for gene silencing in human, mouse, rat DDI2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDI2

    Clone
    Products:
         
    OriGene clones in human, mouse for DDI2 (see all 8)
    OriGene ORF clones in mouse, rat for DDI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDI2 (NM_032341)
    Sino Biological Human cDNA Clone for DDI2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDI2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DDI2
    Browse ESI BIO Cell Lines and PureStem Progenitors for DDI2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDI2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    extracellular1
    nucleus1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDI2
    Interactions:

        Search GeneGlobe Interaction Network for DDI2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDI2 (Q5TDH03 ENSP000004177484) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMC5P621953, ENSP000003105724I2D: score=1 STRING: ENSP00000310572
    PUF60Q9UHX13, ENSP000003220164I2D: score=1 STRING: ENSP00000322016
    UBA52P629873, ENSP000003881074I2D: score=1 STRING: ENSP00000388107
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    RPS27AP629793, ENSP000002723174I2D: score=2 STRING: ENSP00000272317
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with DDI2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDI2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDI2 gene: 
    NM_032341.4  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480945(uc001awx.2) ENST00000486680(uc001aww.3) ENST00000546927
    ENST00000320153(uc009voj.2) ENST00000483899 ENST00000548451
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDI2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDI2 (see all 19):
    hsa-miR-362-3p hsa-let-7d hsa-miR-330-5p hsa-miR-202 hsa-let-7c hsa-miR-766 hsa-miR-4267 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidDDI2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDI2
    Predesigned siRNA for gene silencing in human, mouse, rat DDI2
    Clone
    Products:
         
    OriGene clones in human, mouse for DDI2 (see all 8)
    OriGene ORF clones in mouse, rat for DDI2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDI2 (NM_032341)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDI2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDI2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DDI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDI2
      QuantiTect SYBR Green Assays in human, mouse, rat DDI2
      QuantiFast Probe-based Assays in human, mouse, rat DDI2

    Selected AceView cDNA sequences (see all 39):

    NM_006511 BQ344702 BQ900982 CB118357 BC006011 AW022594 AI174890 BN000122 
    BX282087 BX090334 CB132209 BI003879 BE093517 AI268381 BX482682 AK057374 
    BP356564 BE246849 BM454852 AL598343 AL707355 BE720494 AW937766 H61016 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDI2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTTTGGT
    DDI2 Expression
    About this image

    DDI2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDI2 Protein Expression
        Custom PCR Arrays for DDI2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DDI2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDI2
    QuantiTect SYBR Green Assays in human, mouse, rat DDI2
    QuantiFast Probe-based Assays in human, mouse, rat DDI2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDI2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDI2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddi21 , 5 DNA-damage inducible protein 21, 5 89.22(n)1
    95.99(a)1
      4 (74.69 cM)5
    688171  NM_001017966.21  NP_001017966.11 
     1416775495 
    chicken
    (Gallus gallus)
    Aves DDI21 DNA-damage inducible 1 homolog 2 (S. cerevisiae) 80.69(n)
    89.92(a)
      425541  XM_004947545.1  XP_004947602.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDI26
    DNA-damage inducible 1 homolog 2 (S. cerevisiae)
    90(a)
    1 ↔ 1
    GL343609.1(137359-143660)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC537262 hypothetical protein MGC53726 77.72(n)    BC043869.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ddi22 DNA-damage inducible protein 2 73.54(n)   386644  AY398334.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rngo1 rings lost 55.37(n)
    53.06(a)
      32616  NM_132901.2  NP_573129.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C01G5.66
    Protein C01G5.6 (C01G5.6) mRNA, complete cds
    27(a)
    1 → many
    IV(6522874-6524568) WBGene00015308
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DDI16
    DNA damage-inducible v-SNARE binding protein with ...
    28(a)
    1 → many
    V(456319-457605) YER143W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G132351 AT3G13235 50.11(n)
    41.99(a)
      820522  NM_001202947.1  NP_001189876.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01986001 Os02g0198600 50.59(n)
    42.17(a)
      4328632  NM_001052744.1  NP_001046209.1 


    ENSEMBL Gene Tree for DDI2 (if available)
    TreeFam Gene Tree for DDI2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDI2 gene
    DDI12  
    1 SIMAP similar gene for DDI2 using alignment to 3 protein entries:     DDI2_HUMAN (see all proteins):
    DDI1

    Find genes that share paralogs with DDI2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DDI2
    PGOHUM00000261125


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDI2 (see all 847)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877946611,2
    --15942145(+) GCAATG/TGTTAT 1 -- us2k10--------
    rs1483149121,2
    --15942161(+) ACATTC/TACTGT 1 -- us2k10--------
    rs1141199311,2
    F--15942365(+) GATGCG/ATGCAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1405011501,2
    --15942969(+) ACCTAC/GTTACC 1 -- us2k10--------
    rs120689501,2
    C,H--15943132(+) CCTTAG/ATTCTG 1 -- us2k15Minor allele frequency- A:0.00NS EA NA 420
    rs2012000731,2
    C--15943143(+) GGCCT-/TACCAC 1 -- us2k10--------
    rs1405764941,2
    C--15943215(+) TAAGC-/TTGTGC 1 -- us2k10--------
    rs1167088901,2
    F--15943478(+) GGAAGT/CGAATT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1146349091,2
    F--15943547(+) CTAGAT/CTGAGA 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1164047521,2
    F--15943709(+) TCCTTC/TTCCGC 1 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for DDI2 (15943953 - 15995539 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DDI2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv259731OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDI2
    DNA2.0 Custom Variant and Variant Library Synthesis for DDI2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with DDI2           About GenesLikeMe

    Genetic Association Database (GAD): DDI2
    Human Genome Epidemiology (HuGE) Navigator: DDI2 (1 document)

    Export disorders for DDI2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDI2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with DDI2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 2 Puente X.S.... Lopez-Otin C. (Nat. Rev. Genet. 2003)
    4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    5. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84301 HGNC: 24578 AceView: RSC1A1andDDI2 Ensembl:ENSG00000197312 euGenes: HUgn84301
    ECgene: DDI2 H-InvDB: DDI2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDI2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDI2 gene:
    Search GeneIP for patents involving DDI2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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