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Aliases for DDI2 Gene

Aliases for DDI2 Gene

  • DNA Damage Inducible 1 Homolog 2 2 3 5
  • DDI1, DNA-Damage Inducible 1, Homolog 2 (S. Cerevisiae) 2
  • DNA-Damage Inducible 1 Homolog 2 (S. Cerevisiae) 2
  • DNA-Damage Inducible 1 Homolog 2 2

External Ids for DDI2 Gene

Previous GeneCards Identifiers for DDI2 Gene

  • GC01P015211
  • GC01P015306
  • GC01P015689
  • GC01P015816
  • GC01P015943
  • GC01P014463

Summaries for DDI2 Gene

GeneCards Summary for DDI2 Gene

DDI2 (DNA Damage Inducible 1 Homolog 2) is a Protein Coding gene. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is DDI1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDI2 Gene

Genomics for DDI2 Gene

Regulatory Elements for DDI2 Gene

Enhancers for DDI2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDI2 on UCSC Golden Path with GeneCards custom track

Promoters for DDI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDI2 Gene

Chromosome:
1
Start:
15,617,458 bp from pter
End:
15,669,044 bp from pter
Size:
51,587 bases
Orientation:
Plus strand

Genomic View for DDI2 Gene

Genes around DDI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDI2 Gene

Proteins for DDI2 Gene

  • Protein details for DDI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TDH0-DDI2_HUMAN
    Recommended name:
    Protein DDI1 homolog 2
    Protein Accession:
    Q5TDH0
    Secondary Accessions:
    • A8KAE1
    • Q7RTZ0
    • Q9BRT1

    Protein attributes for DDI2 Gene

    Size:
    399 amino acids
    Molecular mass:
    44523 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DDI2 Gene

    Alternative splice isoforms for DDI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDI2 Gene

Proteomics data for DDI2 Gene at MOPED

Post-translational modifications for DDI2 Gene

  • Ubiquitination at Lys 67, Lys 77, Lys 153, Lys 170, Lys 283, Lys 289, Lys 338, and Lys 389
  • Modification sites at PhosphoSitePlus

Other Protein References for DDI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDI2 Gene

Domains & Families for DDI2 Gene

Suggested Antigen Peptide Sequences for DDI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5TDH0

UniProtKB/Swiss-Prot:

DDI2_HUMAN :
  • Contains 1 ubiquitin-like domain.
  • Belongs to the DDI1 family.
Domain:
  • Contains 1 ubiquitin-like domain.
Family:
  • Belongs to the DDI1 family.
genes like me logo Genes that share domains with DDI2: view

No data available for Gene Families for DDI2 Gene

Function for DDI2 Gene

Gene Ontology (GO) - Molecular Function for DDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with DDI2: view
genes like me logo Genes that share phenotypes with DDI2: view

Animal Model Products

miRNA for DDI2 Gene

miRTarBase miRNAs that target DDI2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDI2 Gene

Localization for DDI2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDI2 Gene COMPARTMENTS Subcellular localization image for DDI2 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with DDI2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDI2 Gene

Pathways & Interactions for DDI2 Gene

SuperPathways for DDI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDI2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DDI2 Gene

Drugs & Compounds for DDI2 Gene

No Compound Related Data Available

Transcripts for DDI2 Gene

Unigene Clusters for DDI2 Gene

DNA-damage inducible 1 homolog 2 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDI2 Gene

No ASD Table

Relevant External Links for DDI2 Gene

GeneLoc Exon Structure for
DDI2
ECgene alternative splicing isoforms for
DDI2

Expression for DDI2 Gene

mRNA expression in normal human tissues for DDI2 Gene

mRNA differential expression in normal tissues according to GTEx for DDI2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for DDI2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1) and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDI2 Gene



SOURCE GeneReport for Unigene cluster for DDI2 Gene Hs.718857

genes like me logo Genes that share expression patterns with DDI2: view

Protein tissue co-expression partners for DDI2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DDI2 Gene

Orthologs for DDI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDI2 35
  • 93.01 (n)
  • 96.21 (a)
DDI2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDI2 35
  • 94.78 (n)
  • 96.97 (a)
DDI2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddi2 35
  • 89.22 (n)
  • 95.99 (a)
Ddi2 16
Ddi2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDI2 35
  • 99.67 (n)
  • 100 (a)
DDI2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddi2 35
  • 88.33 (n)
  • 94.61 (a)
oppossum
(Monodelphis domestica)
Mammalia DDI2 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDI2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDI2 35
  • 80.69 (n)
  • 89.92 (a)
DDI2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDI2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddi2 35
  • 75.89 (n)
  • 86.29 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC53726 35
zebrafish
(Danio rerio)
Actinopterygii ddi2 35
  • 72.15 (n)
  • 81.27 (a)
ddi2 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta rngo 35
  • 55.37 (n)
  • 53.06 (a)
rngo 36
  • 42 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C01G5.6 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DDI1 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G13235 35
  • 50.11 (n)
  • 41.99 (a)
rice
(Oryza sativa)
Liliopsida Os02g0198600 35
  • 50.59 (n)
  • 42.17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9928 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9741 36
  • 42 (a)
OneToMany
Species with no ortholog for DDI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDI2 Gene

ENSEMBL:
Gene Tree for DDI2 (if available)
TreeFam:
Gene Tree for DDI2 (if available)

Paralogs for DDI2 Gene

Paralogs for DDI2 Gene

(1) SIMAP similar genes for DDI2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DDI2 Gene

genes like me logo Genes that share paralogs with DDI2: view

Variants for DDI2 Gene

Sequence variations from dbSNP and Humsavar for DDI2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1122386 -- 15,620,382(+) CATCA(C/T)TATAG intron-variant
rs1122387 -- 15,620,787(+) TAATA(C/T)GTTAT intron-variant
rs941686 -- 15,656,806(-) GCTAG(C/T)TGTAA intron-variant
rs2104038 -- 15,649,492(+) ATGGC(A/G)AAACC intron-variant
rs1980607 -- 15,648,742(+) AAAGC(A/G)AATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDI2 Gene

Variant ID Type Subtype PubMed ID
esv259731 OTHER Complex 20981092

Variation tolerance for DDI2 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDI2 Gene

Disorders for DDI2 Gene

Relevant External Links for DDI2

Genetic Association Database (GAD)
DDI2
Human Genome Epidemiology (HuGE) Navigator
DDI2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDI2

No disorders were found for DDI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDI2 Gene

Publications for DDI2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for DDI2 Gene

Sources for DDI2 Gene

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