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Aliases for DDI2 Gene

Aliases for DDI2 Gene

  • DNA Damage Inducible 1 Homolog 2 2 3 5
  • DDI1, DNA-Damage Inducible 1, Homolog 2 (S. Cerevisiae) 2
  • DNA-Damage Inducible 1 Homolog 2 (S. Cerevisiae) 2
  • DNA-Damage Inducible 1 Homolog 2 2

External Ids for DDI2 Gene

Previous GeneCards Identifiers for DDI2 Gene

  • GC01P015211
  • GC01P015306
  • GC01P015689
  • GC01P015816
  • GC01P015943
  • GC01P014463

Summaries for DDI2 Gene

GeneCards Summary for DDI2 Gene

DDI2 (DNA Damage Inducible 1 Homolog 2) is a Protein Coding gene. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is DDI1.

Additional gene information for DDI2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDI2 Gene

Genomics for DDI2 Gene

Regulatory Elements for DDI2 Gene

Enhancers for DDI2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H016012 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +399.6 399578 9.7 HDGF PKNOX1 ARNT ZFP64 ARID4B ZNF766 ZNF207 ZNF143 FOS SP5 HSPB7 CLCNKA ENSG00000237938 CROCCP3 ARHGEF19 RPS16P1 CROCC SPEN CASP9 ENSG00000224621
GH01H016498 1.6 FANTOM5 ENCODE dbSUPER 9.9 +881.6 881613 2 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF121 GTF3C2 GLIS2 ZNF143 ZNF207 ENSG00000237938 NECAP2 CROCCP3 ARHGEF19 SPATA21 SPEN RPS16P1 ENSG00000224621 DDI2 RCC2
GH01H015787 1.4 Ensembl ENCODE dbSUPER 9.9 +171.0 171032 2 HDAC1 PKNOX1 ATF1 ZSCAN9 RARA GTF3C2 EGR1 FOS ATF7 THAP11 ENSG00000237938 ARHGEF19 SPEN RPS16P1 ENSG00000224621 DDI2 FBLIM1 SLC25A34 RPL12P14
GH01H016544 1.4 Ensembl ENCODE 9.9 +927.9 927857 2 HDGF MLX ARNT ARID4B SIN3A FEZF1 ZNF2 SP3 JUNB REST SPEN CROCC ENSG00000237938 LINC01772 CROCCP3 FLJ37453 ARHGEF19 TRE-TTC3-1 FBXO42 MFAP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDI2 on UCSC Golden Path with GeneCards custom track

Promoters for DDI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for DDI2 Gene

Genomic Locations for DDI2 Gene
51,587 bases
Plus strand

Genomic View for DDI2 Gene

Genes around DDI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDI2 Gene

Proteins for DDI2 Gene

  • Protein details for DDI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DDI1 homolog 2
    Protein Accession:
    Secondary Accessions:
    • A8KAE1
    • Q7RTZ0
    • Q9BRT1

    Protein attributes for DDI2 Gene

    399 amino acids
    Molecular mass:
    44523 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DDI2 Gene

    Alternative splice isoforms for DDI2 Gene


neXtProt entry for DDI2 Gene

Post-translational modifications for DDI2 Gene

  • Ubiquitination at isoforms=2, 367, posLast=7777, posLast=153153, isoforms=2, 3170, isoforms=3283, posLast=289289, isoforms=3338, and posLast=389389
  • Modification sites at PhosphoSitePlus

Other Protein References for DDI2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDI2 Gene

Domains & Families for DDI2 Gene

Gene Families for DDI2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DDI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DDI1 family.
  • Belongs to the DDI1 family.
genes like me logo Genes that share domains with DDI2: view

Function for DDI2 Gene

Phenotypes From GWAS Catalog for DDI2 Gene

Gene Ontology (GO) - Molecular Function for DDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 NOT peptidase activity IDA 27461074
GO:0042802 identical protein binding IDA 27461074
GO:0043130 ubiquitin binding IDA 27461074
genes like me logo Genes that share ontologies with DDI2: view
genes like me logo Genes that share phenotypes with DDI2: view

Animal Model Products

miRNA for DDI2 Gene

miRTarBase miRNAs that target DDI2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDI2 Gene

Localization for DDI2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDI2 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DDI2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDI2 Gene

Pathways & Interactions for DDI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with DDI2: view

No data available for Pathways by source and SIGNOR curated interactions for DDI2 Gene

Drugs & Compounds for DDI2 Gene

No Compound Related Data Available

Transcripts for DDI2 Gene

Unigene Clusters for DDI2 Gene

DNA-damage inducible 1 homolog 2 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDI2 Gene

No ASD Table

Relevant External Links for DDI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDI2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDI2 Gene

mRNA differential expression in normal tissues according to GTEx for DDI2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.6).

Protein differential expression in normal tissues from HIPED for DDI2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.1) and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDI2 Gene

Protein tissue co-expression partners for DDI2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDI2 Gene:


SOURCE GeneReport for Unigene cluster for DDI2 Gene:


Evidence on tissue expression from TISSUES for DDI2 Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with DDI2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDI2 Gene

Orthologs for DDI2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DDI2 33 34
  • 99.67 (n)
(Ornithorhynchus anatinus)
Mammalia DDI2 34
  • 96 (a)
(Canis familiaris)
Mammalia DDI2 33 34
  • 94.78 (n)
(Bos Taurus)
Mammalia DDI2 33 34
  • 93.01 (n)
(Monodelphis domestica)
Mammalia DDI2 34
  • 93 (a)
(Mus musculus)
Mammalia Ddi2 33 16 34
  • 89.22 (n)
(Rattus norvegicus)
Mammalia Ddi2 33
  • 88.33 (n)
(Gallus gallus)
Aves DDI2 33 34
  • 80.69 (n)
(Anolis carolinensis)
Reptilia DDI2 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddi2 33
  • 75.89 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53726 33
(Danio rerio)
Actinopterygii ddi2 33 34
  • 72.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta rngo 33 34
  • 55.37 (n)
(Caenorhabditis elegans)
Secernentea C01G5.6 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DDI1 34
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G13235 33
  • 50.11 (n)
(Oryza sativa)
Liliopsida Os02g0198600 33
  • 50.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9741 34
  • 42 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9928 33
Species where no ortholog for DDI2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDI2 Gene

Gene Tree for DDI2 (if available)
Gene Tree for DDI2 (if available)

Paralogs for DDI2 Gene

Paralogs for DDI2 Gene

(1) SIMAP similar genes for DDI2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDI2: view

Variants for DDI2 Gene

Sequence variations from dbSNP and Humsavar for DDI2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000104427 -- 15,634,862(+) TTCTG(A/G)CCTCA intron-variant
rs1000114925 -- 15,653,253(+) GGACT(A/G)TTTTA intron-variant
rs1000119115 -- 15,617,041(+) TAACT(C/G)CTGTA upstream-variant-2KB
rs1000181848 -- 15,633,065(+) CTGGG(A/G)CTACA intron-variant
rs1000212771 -- 15,630,478(+) AGATA(C/T)GTTGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DDI2 Gene

Variant ID Type Subtype PubMed ID
nsv1006877 CNV gain 25217958
esv3302757 CNV tandem duplication 20981092

Variation tolerance for DDI2 Gene

Residual Variation Intolerance Score: 22.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.05; 21.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDI2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDI2 Gene

Disorders for DDI2 Gene

Relevant External Links for DDI2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDI2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDI2 Gene

Publications for DDI2 Gene

  1. Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog. (PMID: 27461074) Sivá M … Šašková KG (Scientific reports 2016) 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Human and mouse proteases: a comparative genomic approach. (PMID: 12838346) Puente XS … López-Otín C (Nature reviews. Genetics 2003) 3 4 60
  5. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 60

Products for DDI2 Gene

Sources for DDI2 Gene

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