DDI2 Gene
protein-coding GIFtS: 45
GCID: GC01P015943
|
|
DNA-damage inducible 1 homolog 2 (S. cerevisiae)(Previous names: DDI1, DNA-damage inducible 1, homolog 2 (S. cerevisiae)...)
| |
Aliases
for DDI2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DNA-Damage Inducible 1 Homolog 2 (S. Cerevisiae)1 2 | | DDI1, DNA-Damage Inducible 1, Homolog 22 | | MGC148441 | | DNA-Damage Inducible Protein 2 (DDI2)2 | | DDI1, DNA-Damage Inducible 1, Homolog 2 (S. Cerevisiae)1 | | Protein DDI1 Homolog 22 | | RP4-680D5.52 | | |
Export aliases for DDI2 gene to outside databasesPrevious GC identifers: GC01P015211 GC01P015306 GC01P015689 GC01P015816 GC01P014463 |
Summaries
for DDI2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DDI2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDI2 gene promoter:
Bach1 AML1a FOXD1 E2F-2 E4BP4 S8 E2F E2F-1 SEF-1 (1) En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDI2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDI2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36.13DDI2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P015943: view genomic region
(about GC identifiers)
Start:
|
15,943,953 bp from pter |
End:
|
15,995,539 bp from pter |
Size:
|
51,587 bases |
Orientation:
|
plus strand |
|
Proteins
for DDI2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDI2_HUMAN, Q5TDH0 (See
protein sequence)Recommended Name: Protein DDI1 homolog 2 Size: 399 amino acids; 44523 Da
Secondary accessions: A8KAE1 Q7RTZ0 Q9BRT1Alternative splicing: 3 isoforms: Q5TDH0-1 Q5TDH0-2 Q5TDH0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DDI2: NX_Q5TDH0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TDH0
DDI2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115717.3
ENSEMBL proteins: ENSP00000417748 ENSP00000449475 ENSP00000448878
Human Recombinant Protein Products:
DDI2 Antibody Products:
Assay Products for DDI2: |
Protein
Domains /
Families
for DDI2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDI2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5TDH0ProtoNet protein and cluster: Q5TDH0 1 Blocks protein family: IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: DDI2_HUMAN, Q5TDH0Similarity: Belongs to the DDI1 familySimilarity: Contains 1 ubiquitin-like domain |
Function
for DDI2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDI2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDI2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DDI2 (NM_032341) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDI2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDI2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDI2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004190 | aspartic-type endopeptidase activity |
IEA | -- |
DDI2 for ontologies About GeneDecksing
|
Pathways & Interactions
for DDI2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDI2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/14 Interacting proteins for DDI2 (Q5TDH03 ENSP000004177484) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
DDI2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DDI2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DDI2
Search CenterWatch for drugs/clinical trials and news about DDI2
|
Transcripts
for DDI2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DDI2 gene: NM_032341.4 Unigene Cluster for DDI2: DNA-damage inducible 1 homolog 2 (S. cerevisiae) Hs.718857 [show with all ESTs]Unigene Representative Sequence: NM_0323416 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000480945(uc001awx.2) ENST00000486680(uc001aww.3) ENST00000546927
ENST00000320153(uc009voj.2) ENST00000483899 ENST00000548451
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDI2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDI2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DDI2 (NM_032341) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDI2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDI2 |
Additional cDNA sequence: AK057374.1 AK293006.1 BC006011.1 5 DOTS entries: DT.40207652 DT.86837752 DT.100725088 DT.91663529 DT.95304867 24/39 AceView cDNA sequences (see all 39): CB118357 BX090334 BX282087 AW022594 BQ900982 AI174890 BI003879 BN000122 CB132209 NM_006511 BQ344702 BC006011 BP356564 BX482682 BM454852 AK057374 AI268381 AL598343 BE093517 BE246849 AL707355 AW937766 BE720494 BI003878
GeneLoc Exon Structure
|
Expression
for DDI2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDI2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACTTTTGGT
About this image
See DDI2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDI2
SOURCE GeneReport for Unigene cluster: Hs.718857
SABiosciences Custom PCR Arrays for DDI2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDI2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDI2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDI2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDI2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDI2 |
Orthologs
for DDI2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DDI2 gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for DDI2 (if available)
TreeFam Gene Tree for DDI2 (if available) |
Paralogs
for DDI2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DDI2 gene
- DDI12
1 SIMAP similar gene for DDI2 using alignment to 3 protein entries: DDI2_HUMAN (see all proteins):DDI1
DDI2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DDI2
PGOHUM00000261125
|
Genomic Variants
for DDI2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DDI2 (15943953 - 15995539 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DDI2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDI2 |
|
Disorders
/ Diseases
for DDI2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DDI2 for disorders About GeneDecksing
1  disease for DDI2: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: DDI2 (1 document)
Export disorders for DDI2 gene to outside databases
|
Publications
for DDI2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DDI2 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with DDI2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 2 Puente X.S.... Lopez-Otin C. (2003)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
|
External Searches for DDI2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DDI2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDI2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDI2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DDI2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DDI2 gene:
Search GeneIP for patents involving DDI2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDI2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DDI2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDI2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DDI2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DDI2 | | OriGene 3'-UTR Clone for DDI2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDI2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDI2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DDI2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DDI2 | | OriGene Custom Protein Services for DDI2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDI2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDI2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDI2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDI2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDI2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDI2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DDI2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DDI2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDI2 |
|  |  |  | | | | ThermoFisher Antibodies for DDI2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDI2 |
|
|
|
|
