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Aliases for DDI1 Gene

Aliases for DDI1 Gene

  • DNA Damage Inducible 1 Homolog 1 2 3 5
  • DDI1, DNA-Damage Inducible 1, Homolog 1 (S. Cerevisiae) 2
  • DNA-Damage Inducible 1 Homolog 1 (S. Cerevisiae) 2
  • DNA-Damage Inducible 1 Homolog 1 2

External Ids for DDI1 Gene

Previous GeneCards Identifiers for DDI1 Gene

  • GC00U915586
  • GC11P103412
  • GC11U900686
  • GC11P103907
  • GC11P099836

Summaries for DDI1 Gene

GeneCards Summary for DDI1 Gene

DDI1 (DNA Damage Inducible 1 Homolog 1) is a Protein Coding gene. GO annotations related to this gene include aspartic-type endopeptidase activity. An important paralog of this gene is DDI2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDI1 Gene

Genomics for DDI1 Gene

Regulatory Elements for DDI1 Gene

Genomic Location for DDI1 Gene

104,036,580 bp from pter
104,039,194 bp from pter
2,615 bases
Plus strand

Genomic View for DDI1 Gene

Genes around DDI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDI1 Gene

Proteins for DDI1 Gene

  • Protein details for DDI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein DDI1 homolog 1
    Protein Accession:
    Secondary Accessions:
    • Q7Z4U6
    • Q8WTS3

    Protein attributes for DDI1 Gene

    396 amino acids
    Molecular mass:
    44124 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DDI1 Gene

neXtProt entry for DDI1 Gene

Proteomics data for DDI1 Gene at MOPED

Post-translational modifications for DDI1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DDI1

No data available for DME Specific Peptides for DDI1 Gene

Domains & Families for DDI1 Gene

Suggested Antigen Peptide Sequences for DDI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ubiquitin-like domain.
  • Belongs to the DDI1 family.
  • Contains 1 ubiquitin-like domain.
  • Belongs to the DDI1 family.
genes like me logo Genes that share domains with DDI1: view

No data available for Gene Families for DDI1 Gene

Function for DDI1 Gene

Gene Ontology (GO) - Molecular Function for DDI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with DDI1: view
genes like me logo Genes that share phenotypes with DDI1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DDI1 Gene

Localization for DDI1 Gene

Subcellular locations from

Jensen Localization Image for DDI1 Gene COMPARTMENTS Subcellular localization image for DDI1 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDI1 Gene

Pathways & Interactions for DDI1 Gene

SuperPathways for DDI1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDI1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DDI1 Gene

Drugs & Compounds for DDI1 Gene

No Compound Related Data Available

Transcripts for DDI1 Gene

mRNA/cDNA for DDI1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DDI1 Gene

DNA-damage inducible 1 homolog 1 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDI1 Gene

No ASD Table

Relevant External Links for DDI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDI1 Gene

mRNA expression in normal human tissues for DDI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDI1 Gene

This gene is overexpressed in Bone marrow stromal cell (45.9), Peripheral blood mononuclear cells (17.1), and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DDI1 Gene

SOURCE GeneReport for Unigene cluster for DDI1 Gene Hs.591941

genes like me logo Genes that share expression patterns with DDI1: view

Protein tissue co-expression partners for DDI1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDI1 Gene

Orthologs for DDI1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DDI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDI1 35
  • 78.63 (n)
  • 80.26 (a)
DDI1 36
  • 79 (a)
(Canis familiaris)
Mammalia DDI1 35
  • 80.96 (n)
  • 83.76 (a)
DDI1 36
  • 82 (a)
(Mus musculus)
Mammalia Ddi1 35
  • 80.54 (n)
  • 82.74 (a)
Ddi1 16
Ddi1 36
  • 77 (a)
(Pan troglodytes)
Mammalia DDI1 35
  • 98.98 (n)
  • 98.98 (a)
(Rattus norvegicus)
Mammalia Ddi1 35
  • 80.05 (n)
  • 83.59 (a)
(Monodelphis domestica)
Mammalia DDI1 36
  • 69 (a)
fruit fly
(Drosophila melanogaster)
Insecta rngo 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea C01G5.6 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DDI1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9741 36
  • 41 (a)
Species with no ortholog for DDI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for DDI1 Gene

Gene Tree for DDI1 (if available)
Gene Tree for DDI1 (if available)

Paralogs for DDI1 Gene

Paralogs for DDI1 Gene

(1) SIMAP similar genes for DDI1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DDI1: view

Variants for DDI1 Gene

Sequence variations from dbSNP and Humsavar for DDI1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_032259 -
VAR_032260 -
VAR_032261 -

Structural Variations from Database of Genomic Variants (DGV) for DDI1 Gene

Variant ID Type Subtype PubMed ID
esv2750977 CNV Gain 17911159

Variation tolerance for DDI1 Gene

Residual Variation Intolerance Score: 81.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDI1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDI1 Gene

Disorders for DDI1 Gene

Relevant External Links for DDI1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDI1 Gene

Publications for DDI1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3

Products for DDI1 Gene

Sources for DDI1 Gene

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