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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DDI1 Gene

protein-coding GIFtS: 45
GCID: GC11P103907

DNA-damage inducible 1 homolog 1 (S. cerevisiae)

(Previous names: DDI1, DNA-damage inducible 1, homolog 1 (S. cerevisiae)...)

Explore 1 disease affiliated with
DDI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DNA-Damage Inducible 1 Homolog 1 (S. Cerevisiae)¹ ²
FLJ36017¹
DDI1, DNA-Damage Inducible 1, Homolog 1 (S. Cerevisiae)¹
DDI1, DNA-Damage Inducible 1, Homolog 1²
DNA-Damage Inducible Protein 1²
Protein DDI1 Homolog 1²

External Ids:	HGNC: 18961¹	Entrez Gene: 414301²	Ensembl: ENSG00000170967⁷	UniProtKB: Q8WTU0³

Export aliases for DDI1 gene to outside databases

Previous GC identifers: GC00U915586 GC11P103412 GC11U900686 GC11P099836

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DDI1 gene promoter:
AML1a RREB-1 MyoD HNF-3beta Cdc5 Tal-1beta CREB deltaCREB ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DDI1 promoter sequence

Search SABiosciences Chromatin IP Primers for DDI1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3

DDI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDI1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P103907: view genomic region (about GC identifiers)

Start:	103,907,308 bp from pter	End:	103,909,922 bp from pter
Size:	2,615 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DDI1_HUMAN, Q8WTU0 (See protein sequence)

Recommended Name: Protein DDI1 homolog 1

Size: 396 amino acids; 44124 Da

1 PDB 3D structure from and Proteopedia for DDI1:

3S8I (3D)

Secondary accessions: Q7Z4U6 Q8WTS3

Explore the universe of human proteins at neXtProt for DDI1: NX_Q8WTU0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WTU0

DDI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001001711.1

ENSEMBL proteins:

ENSP00000302805

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DDI1 for domains About GeneDecksing

4 InterPro domains/families:

IPR021109 Peptidase_aspartic

IPR019103 Peptidase_aspartic_DDI1-type

IPR000626 Ubiquitin

IPR019955 Ubiquitin_supergroup

Graphical View of Domain Structure for InterPro Entry Q8WTU0

ProtoNet protein and cluster: Q8WTU0

1 Blocks protein family: IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: DDI1_HUMAN, Q8WTU0

Similarity: Belongs to the DDI1 family

Similarity: Contains 1 ubiquitin-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004190	aspartic-type endopeptidase activity	IEA	--

DDI1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for DDI1:

Big cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DDI1

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/13 Interacting proteins for DDI1 (Q8WTU0^{2, 3} ENSP00000302805⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DVL2	O14641²^,³, ENSP00000005340⁴	MINT-67236 I2D: score=4 STRING: ENSP00000005340
ADRM1	Q16186³, ENSP00000253003⁴	I2D: score=1 STRING: ENSP00000253003
RAD23B	P54727³, ENSP00000350708⁴	I2D: score=5 STRING: ENSP00000350708
CCL28	Q9NRJ3³	I2D: score=1
PSMD2	ENSP00000310129⁴	STRING: ENSP00000310129

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--

DDI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for DDI1 gene:

NM_001001711.2

Unigene Cluster for DDI1:

DNA-damage inducible 1 homolog 1 (S. cerevisiae)

Hs.591941 [show with all ESTs]

Unigene Representative Sequence: NM_001001711

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000302259(uc001phr.2)

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Additional cDNA sequence:

AF429971.1 AK093336.1 BC021172.2 BC021710.1 BC022017.2 BC022018.1

1 DOTS entry:

DT.99958084

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DDI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

DDI1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DDI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDI1

SOURCE GeneReport for Unigene cluster: Hs.591941

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDI1 gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
zebrafish (Danio rerio)	Actinopterygii	ddi2⁶	DNA-damage inducible protein 2	66(a)	1 → many	6(40485495-40494338)
fruit fly (Drosophila melanogaster)	Insecta	rngo⁶	rings lost	40(a)	1 → many	X(16335466-16339400)
worm (Caenorhabditis elegans)	Secernentea	C01G5.6⁶	Protein C01G5.6	26(a)	1 → many	IV(6522863-6524557)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G13235⁶	DNA damage-inducible protein 1	31(a)	possible ortholog	3(4271212-4274455)
rice (Oryza sativa)	Liliopsida	--	Ubiquitin family domain containing protein, expres...	32(a)	possible ortholog	2(5523987-5528724)

ENSEMBL Gene Tree for DDI1 (if available)
TreeFam Gene Tree for DDI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DDI1 gene

DDI2²

1 SIMAP similar gene for DDI1 using alignment to 1 protein entry: DDI1_HUMAN:

DDI2

DDI1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DDI1
1 CNV: 8694

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DDI1 for disorders About GeneDecksing

1 disease for DDI1: About MalaCards

malaria

Human Genome Epidemiology (HuGE) Navigator: DDI1 (3 documents)

Export disorders for DDI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DDI1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DDI1)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
A genomic analysis of rat proteases and protease inhibitors. (PubMed id 15060002)¹ Puente X.S. and Lopez-Otin C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 414301	HGNC: 18961	Ensembl:ENSG00000170967	euGenes: HUgn414301	ECgene: DDI1
H-InvDB: DDI1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DDI1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DDI1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DDI1 gene:
Search GeneIP for patents involving DDI1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDI1

	SwitchGear 3'UTR luciferase reporter plasmids for DDI1
	SwitchGear Promoter luciferase reporter plasmids for DDI1

Search ThermoFisher Antibodies for DDI1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDI1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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DDI1 Gene

DNA-damage inducible 1 homolog 1 (S. cerevisiae)

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DDI1 Gene

DNA-damage inducible 1 homolog 1 (S. cerevisiae)

Aliasesfor DDI1 gene

Summariesfor DDI1 gene

Genomic Viewsfor DDI1 gene

Proteinsfor DDI1 gene

Protein Domains /Familiesfor DDI1 gene

Functionfor DDI1 gene

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Genome Databases showing DDI1 gene

Other Databases showing DDI1 gene

Specialized Databases showing DDI1 gene

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Aliases
for DDI1 gene

Summaries
for DDI1 gene

Genomic Views
for DDI1 gene

Proteins
for DDI1 gene

Protein Domains /
Families
for DDI1 gene

Function
for DDI1 gene

Pathways & Interactions
for DDI1 gene

Drugs & Compounds
for DDI1 gene

Transcripts
for DDI1 gene

Expression
for DDI1 gene

Orthologs
for DDI1 gene

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for DDI1 gene

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for DDI1 gene

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for DDI1 gene

Publications
for DDI1 gene

Intellectual Property
for DDI1 gene

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for DDI1 gene