Aliases for DDC Gene
External Ids for DDC Gene
Previous GeneCards Identifiers for DDC Gene
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
GeneCards Summary for DDC Gene
DDC (Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase)) is a Protein Coding gene. Diseases associated with DDC include aromatic l-amino acid decarboxylase deficiency and aromatic amino acid decarboxylase deficiency. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein domain specific binding and amino acid binding. An important paralog of this gene is GAD1.
UniProtKB/Swiss-Prot for DDC Gene
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine
L-aromatic amino-acid decarboxylase (AADC) (EC: 126.96.36.199) is involved in conversion of L-dopa to dopamine and 5-HTP to serotonin.