Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDC Gene

protein-coding   GIFtS: 73
GCID: GC07M050526

Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dopa Decarboxylase (Aromatic L-Amino Acid Decarboxylase)1 2
AADC2 3
EC 4.1.1.283 8
Aromatic-L-Amino-Acid Decarboxylase2
DOPA Decarboxylase3
EC 4.1.18

External Ids:    HGNC: 27191   Entrez Gene: 16442   Ensembl: ENSG000001324377   OMIM: 1079305   UniProtKB: P207113   

Export aliases for DDC gene to outside databases

Previous GC identifers: GC07M049990 GC07M050233 GC07M050267 GC07M050300 GC07M050493 GC07M050377


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDC Gene:
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine,
L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic
L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism
that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants
encoding different isoforms have been identified for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for DDC Gene: 
DDC (dopa decarboxylase (aromatic L-amino acid decarboxylase)) is a protein-coding gene. Diseases associated with DDC include aromatic amino acid decarboxylase deficiency, and postural hypotension, and among its related super-pathways are Amine-derived hormones and Catecholamine biosynthesis. GO annotations related to this gene include amino acid binding and protein domain specific binding. An important paralog of this gene is GAD1.

UniProtKB/Swiss-Prot: DDC_HUMAN, P20711
Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan
to serotonin and L-tryptophan to tryptamine

summary for DDC Gene:
L-aromatic amino-acid decarboxylase (AADC) (EC: 4.1.1.28) is involved in conversion of L-dopa to dopamine and
5-HTP to serotonin.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_033968.6  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDC gene promoter:
         SRF   HNF-1   SRF (504 AA)   NRSF form 1   NRSF form 2   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDC promoter sequence
   Search SABiosciences Chromatin IP Primers for DDC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p12.2   Ensembl cytogenetic band:  7p12.1   HGNC cytogenetic band: 7p12.1

DDC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDC gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M050526:  view genomic region     (about GC identifiers)

Start:
50,526,134 bp from pter      End:
50,633,154 bp from pter
Size:
107,021 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 50,532,205-50,639,203     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDC_HUMAN, P20711 (See protein sequence)
Recommended Name: Aromatic-L-amino-acid decarboxylase  
Size: 480 amino acids; 53926 Da
Cofactor: Pyridoxal phosphate
Subunit: Homodimer
3 PDB 3D structures from and Proteopedia for DDC:
3RBF (3D)        3RBL (3D)        3RCH (3D)    
Secondary accessions: C9IYA0 E7ER62 E7EU95 Q16723 Q5W5T9 Q75MJ6
Alternative splicing: 4 isoforms:  P20711-1   P20711-2   P20711-3   P20711-4   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for DDC: NX_P20711

Explore proteomics data for DDC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20711

  • 4/16 DME Specific Peptides for DDC (P20711) (see all 16)
     GGGVIQG  RRFRSLK  HVDAAYAG  SPACTELE 

    DDC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDC Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_000781.1  NP_001076440.1  NP_001229815.1  NP_001229816.1  NP_001229817.1  NP_001229818.1  NP_001229819.1  

    ENSEMBL proteins: 
     ENSP00000350616   ENSP00000399184   ENSP00000393724   ENSP00000395069   ENSP00000403644  
     ENSP00000389422   ENSP00000370371   ENSP00000408626  
    Reactome Protein details: P20711
    Human Recombinant Protein Products for DDC: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DDC (Dopa Decarboxylase/DDC)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for DDC
    OriGene Protein Over-expression Lysate for DDC
    OriGene MassSpec for DDC 
    OriGene Custom Protein Services for DDC
    GenScript Custom Purified and Recombinant Proteins Services for DDC
    Novus Biologicals DDC Proteins
    Novus Biologicals DDC Lysates
    Sino Biological Recombinant Protein for DDC
    Sino Biological Cell Lysate for DDC 
    ProSpec Recombinant Protein for DDC
    Cloud-Clone Corp. Proteins for DDC 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0008021synaptic vesicle IEA--
    GO:0030424axon IEA--
    GO:0043025neuronal cell body IEA--

    DDC for ontologies           About GeneDecksing



    DDC Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DDC
    R&D Systems Antibodies for DDC (Dopa Decarboxylase/DDC)
    Cell Signaling Technology (CST) Antibodies for DDC 
    OriGene Antibodies for DDC
    OriGene Custom Antibody Services for DDC
    GenScript Custom Superior Antibodies Services for DDC
    Novus Biologicals DDC Antibodies
    Abcam antibodies for DDC
    Cloud-Clone Corp. Antibodies for DDC 
    ThermoFisher Antibody for DDC
    LSBio Antibodies in human, mouse, rat for DDC 

    Assay Products for DDC: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDC 
    Cloud-Clone Corp. CLIAs for DDC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: L-Aromatic amino-acid decarboxylase  
    Decarboxylases

    5/6 InterPro protein domains (see all 6):
     IPR002129 PyrdxlP-dep_de-COase
     IPR021115 Pyridoxal-P_BS
     IPR010977 Aromatic_deC
     IPR015422 PyrdxlP-dep_Trfase_major_sub2
     IPR015424 PyrdxlP-dep_Trfase

    Graphical View of Domain Structure for InterPro Entry P20711

    ProtoNet protein and cluster: P20711

    2 Blocks protein domains:
    IPB002129 Pyridoxal-dependent decarboxylase
    IPB010977 Aromatic-L-amino-acid decarboxylase


    UniProtKB/Swiss-Prot: DDC_HUMAN, P20711
    Similarity: Belongs to the group II decarboxylase family


    DDC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDC_HUMAN, P20711
    Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan
    to serotonin and L-tryptophan to tryptamine
    Catalytic activity: L-dopa = dopamine + CO(2)
    Catalytic activity: 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2)

         Genatlas biochemistry entry for DDC:
    DOPA decarboxylase,aromatic L-amino acid decarboxylase

         Enzyme Numbers (IUBMB): EC 4.1.1.281 2 EC 4.1.12

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004058aromatic-L-amino-acid decarboxylase activity TAS--
    GO:0005515protein binding IPI12864730
    GO:0016597amino acid binding IEA--
    GO:0016829lyase activity ----
    GO:0016831carboxy-lyase activity ----
         
    DDC for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ddc):
     behavior/neurological  cardiovascular system  cellular  growth/size  homeostasis/metabolism 
     immune system  mortality/aging  nervous system  renal/urinary system  vision/eye 

    DDC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDC 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDC
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DDC:
    hsa-miR-3065-5p
    SwitchGear 3'UTR luciferase reporter plasmidDDC 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDC
    Sirion Biotech Customized adenovirus for overexpression of DDC

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DDC (see all 12)
    OriGene ORF clones in mouse, rat for DDC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DDC (NM_000790)
    Sino Biological Human cDNA Clone for DDC
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDC
    Sirion Biotech Customized lentivirus for stable overexpression of DDC 
                         Customized lentivirus expression plasmids for stable overexpression of DDC 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDC
    Search LifeMap BioReagents cell lines for DDC
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DDC About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Regulation of thyroid hormone activity
    Amine-derived hormones0.43
    Serotonin and melatonin biosynthesis0.36
    serotonin and melatonin biosynthesis0.36
    Biogenic Amine Synthesis0.32
    2catecholamine biosynthesis
    Catecholamine biosynthesis0.50
    catecholamine biosynthesis0.50
    3Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan metabolism0.46
    4Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics0.44
    Nicotine Activity on Dopaminergic Neurons0.44
    5Metabolism
    Metabolism0.40
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for DDC
        Tyrosine metabolism p.1 (dopamine)


    1 Cell Signaling Technology (CST) Pathway for DDC
        Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for DDC
        Tyrosine metabolism p.1 (dopamine)

    5/11 BioSystems Pathways for DDC (see all 11)
        Biogenic Amine Synthesis
    Nicotine Activity on Dopaminergic Neurons
    SIDS Susceptibility Pathways
    Parkinsons Disease Pathway
    catecholamine biosynthesis


    5        Reactome Pathways for DDC
        Catecholamine biosynthesis
    Amine-derived hormones
    Serotonin and melatonin biosynthesis
    Metabolism
    Metabolism of amino acids and derivatives

    3 PharmGKB Pathways for DDC
        Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
    Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

    5/10         Kegg Pathways  (Kegg details for DDC) (see all 10):
        Histidine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism
    Tryptophan metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: DDC_HUMAN, P20711
    Pathway: Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2


    DDC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for DDC (P207111, 3 ENSP000003506164) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARP102751, 3, ENSP000003638224EBI-1632155,EBI-608057 I2D: score=2 STRING: ENSP00000363822
    THP071013, ENSP000003705714I2D: score=1 STRING: ENSP00000370571
    CSNK2A1P684003I2D: score=2 
    EEF1A1P681043I2D: score=2 
    KIF5BP331763I2D: score=2 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006520cellular amino acid metabolic process IEA--
    GO:0007623circadian rhythm IEA--
    GO:0009636response to toxic substance ----
    GO:0010259multicellular organismal aging IEA--
    GO:0015842synaptic vesicle amine transport IEA--

    DDC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DDC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Enzo Life Sciences drugs & compounds for DDC

    Compounds for DDC available from Tocris Bioscience    About this table
    CompoundAction CAS #
    DFMOOrnithine decarboxylase inhibitor[70052-12-9]
    L-(-)-alpha-MethyldopaAromatic L-amino acid decarboxylase inhibitor[555-30-6]

    10/18 HMDB Compounds for DDC (see all 18)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1,2-Dehydrosalsolinol3,4-dihydro-1-methyl-6,7-Isoquinolinediol (see all 2)4602-81-7--
    1-Phenylethylaminea-phenylethylamine (see all 17)98-84-0--
    5-Hydroxy-L-tryptophan(+-)-5-Hydroxytryptophan (see all 21)4350-09-8--
    5-Hydroxykynurenamine5-Hydroxykynuramine (see all 3)708-23-6--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    DL-Dopa2-Amino-3-(3,4-dihydroxyphenyl)propanoate (see all 19)63-84-3--
    Dopamine2-(3,4-Dihydroxyphenyl)ethylamine (see all 22)62-31-7--
    Histamine1H-Imidazole-4-ethanamine (see all 27)51-45-6--
    Hydroxykynurenine3-(3-hydroxyanthraniloyl)-Alanine (see all 7)484-78-6--
    L-Dopa(-)-Dopa (see all 58)59-92-7--

    1 DrugBank Compound for DDC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor11709201 11085948 12679420 15070923 15965967

    10/48 Novoseek inferred chemical compound relationships for DDC gene (see all 48)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-amino acid 98.4 413 1357595 (4), 16876014 (3), 9309516 (3), 9924972 (3) (see all 99)
    levodopa 90.3 231 11144954 (5), 10439935 (4), 10569946 (4), 9633680 (3) (see all 91)
    vanillactic acid 88.4 1 16288991 (1)
    carbidopa 85.9 22 10934669 (2), 7475917 (1), 9633680 (1), 19922897 (1) (see all 17)
    entacapone 85 17 10439935 (3), 19039224 (1), 19570145 (1), 15907741 (1) (see all 7)
    3-hydroxybenzylhydrazine 84.7 8 8783276 (1), 10411985 (1), 17437548 (1), 8095975 (1) (see all 8)
    dopamine 83.3 248 10877910 (3), 1350071 (3), 10821639 (3), 8458598 (2) (see all 99)
    l-dops 82.4 3 17214596 (1), 12169865 (1), 8836986 (1)
    benserazide 81.6 13 7475917 (1), 9633680 (1), 11459076 (1), 19922897 (1) (see all 12)
    dl-threo-dihydroxyphenylserine 80.4 2 8486891 (1), 2217667 (1)

    Search CenterWatch for drugs/clinical trials and news about DDC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDC gene (7 alternative transcripts): 
    NM_000790.3  NM_001082971.1  NM_001242886.1  NM_001242887.1  NM_001242888.1  NM_001242889.1  NM_001242890.1  

    Unigene Cluster for DDC:

    Dopa decarboxylase (aromatic L-amino acid decarboxylase)
    Hs.359698  [show with all ESTs]
    Unigene Representative Sequence: NM_001082971
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357936(uc003tpf.4 uc022adb.1 uc022adc.1 uc022add.1 uc022ade.1)
    ENST00000431062 ENST00000444733 ENST00000426377 ENST00000495320 ENST00000444124(uc003tpg.4)
    ENST00000430300 ENST00000494914 ENST00000380984(uc022adf.1) ENST00000489162
    ENST00000420203
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DDC
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DDC:
    hsa-miR-3065-5p
    SwitchGear 3'UTR luciferase reporter plasmidDDC 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DDC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDC
    Clone
    Products:
         
    OriGene clones in human, mouse for DDC (see all 12)
    OriGene ORF clones in mouse, rat for DDC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DDC (NM_000790)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDC
    Sirion Biotech Customized lentivirus for stable overexpression of DDC 
                         Customized lentivirus expression plasmids for stable overexpression of DDC 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDC
    OriGene qSTAR qPCR primer pairs in human, mouse for DDC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDC

    Additional mRNA sequence: 

    AJ310724.1 AK298321.1 AK298392.1 BC000485.1 BC008366.1 BT007009.1 CR456724.1 M76180.1 
    M88700.1 

    12 DOTS entries:

    DT.100746972  DT.75124942  DT.91717614  DT.121106040  DT.100759329  DT.121106025  DT.40245842  DT.101981525 
    DT.100746974  DT.100701656  DT.75124943  DT.86844598 

    24/116 AceView cDNA sequences (see all 116):

    AW026053 BI963083 BC008366 CD013934 CA396773 BT007009 BM852976 BI765169 
    BC000485 CD013938 AA341220 CD013937 AI651192 NM_000790 AI291396 CD013935 
    CK903649 CR612794 CR623782 CD013936 CB121989 BM692558 BQ638460 BQ070282 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDC expression in normal human tissues (normalized intensities)      DDC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTAAATG
    DDC Expression
    About this image


    DDC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 28 entries
             Embryonic Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Substantia Nigra   
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Dopaminergic Amacrine Cells Inner Nuclear Layer
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/atrium   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Rhombencephalon

    See DDC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDC

    SOURCE GeneReport for Unigene cluster: Hs.359698
        SABiosciences Expression via Pathway-Focused PCR Arrays including DDC: 
              Parkinson's Disease in human mouse rat
              Amino Acid Metabolism II in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDC
    OriGene qSTAR qPCR primer pairs in human, mouse for DDC
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDC
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDC
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDC gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddc1 , 5 dopa decarboxylase1, 5 83.96(n)1
    89.37(a)1
      11 (7.09 cM)5
    131951  NM_001190448.11  NP_001177377.11 
     118141015 
    chicken
    (Gallus gallus)
    Aves DDC1 dopa decarboxylase (aromatic L-amino acid decarboxylase) 73.53(n)
    77.52(a)
      420947  XM_419032.3  XP_419032.3 
    lizard
    (Anolis carolinensis)
    Reptilia DDC6
    Uncharacterized protein
    74(a)
    1 ↔ 1
    6(54416220-54482195)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.81462 Transcribed sequence with moderate similarity to protein more 77.19(n)    CF151014.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa56d052 Danio rerio cDNA clone MGC65801 IMAGE6791927, complete more 77.05(n)    BC056292.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ddc1 , 3 dopamine biosynthesis from tyrosine
    aromatic-L-amino more3
    Dopa decarboxylase1
    60(a)
    (best of 5)3
    61.61(n)1
    61.05(a)1
      2 37C13
    351901  NM_165279.11  NP_724163.11 
    worm
    (Caenorhabditis elegans)
    Secernentea tdc-13 aromatic-L-amino-acid decarboxylase 55(a)
    (best of 4)
      II(8270530-8273464)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G203401 Tyrosine decarboxylase 1 53.12(n)
    50.75(a)
      816553  NM_179668.1  NP_849999.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g04375001 hypothetical protein 53.41(n)
    49.46(a)
      4343080  NM_001066044.1  NP_001059509.1 


    ENSEMBL Gene Tree for DDC (if available)
    TreeFam Gene Tree for DDC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDC gene
    GAD12  GADL12  HDC2  GAD22  CSAD2  
    3 SIMAP similar genes for DDC using alignment to 6 protein entries:     DDC_HUMAN (see all proteins):
    HDC    CSAD    pcap

    DDC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2693 SNPs in DDC are shown (see all 2693)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0193094
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)4--see VAR_0193092 G S mis40--------
    VAR_0461384
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)4--see VAR_0461382 A V mis40--------
    VAR_0461414
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)4--see VAR_0461412 A T mis40--------
    VAR_0461374
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)4--see VAR_0461372 P H mis40--------
    VAR_0461444
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)4--see VAR_0461442 L I mis40--------
    VAR_0461434
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)4--see VAR_0461432 R Q mis40--------
    VAR_0461424
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)4--see VAR_0461422 F L mis40--------
    VAR_0461404
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)4--see VAR_0461402 S F mis40--------
    VAR_0461394
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)4--see VAR_0461392 S R mis40--------
    VAR_0147884
    ----see VAR_0147882 M V mis40--------

    HapMap Linkage Disequilibrium report for DDC (50526134 - 50633154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DDC:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2678897CNV Deletion23128226
    nsv507390CNV Insertion20534489
    nsv516640CNV Loss19592680
    nsv888021CNV Loss21882294


    Human Gene Mutation Database (HGMD): DDC

    Locus Specific Mutation Databases (LSDB): DDC
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DDC
    DNA2.0 Custom Variant and Variant Library Synthesis for DDC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 107930   
    OMIM disorders: 608643  
    UniProtKB/Swiss-Prot: DDC_HUMAN, P20711
  • Aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]: An inborn error in neurotransmitter
    metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor
    delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is
    early in infancy and inheritance is autosomal recessive. Note=The disease is caused by mutations affecting the
    gene represented in this entry

  • 20/59 diseases for DDC (see all 59):    About MalaCards
    aromatic amino acid decarboxylase deficiency    postural hypotension    dopamine beta-hydroxylase deficiency    peripheral nervous system disease
    autoimmune polyendocrine syndrome    paranoid schizophrenia    neuroepithelioma    supratentorial primitive neuroectodermal tumor
    addison's disease    nervous system disease    fabry disease    vitiligo
    angiomyolipoma    nicotine dependence    primitive neuroectodermal tumor    hyperinsulinism
    phaeochromocytoma    human immunodeficiency virus infectious disease    parkinson's disease    turner syndrome

    2 diseases from the University of Copenhagen DISEASES database for DDC:
    Parkinson's disease     Autoimmune polyendocrine syndrome

    DDC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/33 Novoseek inferred disease relationships for DDC gene (see all 33)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    apeced 83.3 34 8989249 (5), 17200166 (3), 10634424 (3), 9276443 (3) (see all 9)
    parkinson disease 77.2 36 7893377 (3), 10392841 (3), 10439935 (2), 19828868 (2) (see all 21)
    addisons disease 56.1 7 10634424 (3), 17200166 (2), 18088406 (1)
    neuroepithelioma 50.8 1 8510497 (1)
    hypotension orthostatic 46.3 1 2217667 (1)
    parkinsonism 42.7 1 9710269 (1)
    developmental delay 41.9 9 17240182 (1), 19231266 (1), 15079002 (1), 18754761 (1)
    vitiligo 33.1 3 8989249 (1), 10634424 (1)
    small cell lung cancer 30.8 2 8806108 (2)
    hepatitis autoimmune 30.8 2 17200166 (1)

    Genatlas disease: DDC
    hypotonia,developmental delay and paroxysmal movements with oculogyric crises

    Genetic Association Database (GAD): DDC
    Human Genome Epidemiology (HuGE) Navigator: DDC (33 documents)

    Export disorders for DDC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDC gene, integrated from 9 sources (see all 353):
    (articles sorted by number of sources associating them with DDC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs. (PubMed id 1612608)1, 2, 3, 9 Scherer L.J.... Marsh L.J. (1992)
    2. Aromatic L-amino acid decarboxylase deficiency: clinical features, treatment, and prognosis. (PubMed id 15079002)1, 2, 9 Pons R.... De Vivo D.C. (2004)
    3. Identification of a neuron-specific promoter of human aromatic L- amino acid decarboxylase gene. (PubMed id 8510497)1, 2, 9 Van Thai A.... Weber M.J. (1993)
    4. Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis. (PubMed id 1540578)1, 2, 9 Sumi-Ichinose C.... Nagatsu T. (1992)
    5. Localisation of the gene for human aromatic L-amino acid decarboxylase (DDC) to chromosome 7p13-->p11 by in situ hybridisation. (PubMed id 1395716)1, 2, 9 Craig S.P.... Craig I.W. (1992)
    6. Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases. (PubMed id 22143761)1, 2 Giardina G....Cutruzzola F. (2011)
    7. Genetic associations of brain structural networks in schizophrenia: a preliminary study. (PubMed id 20691427)1, 4 Jagannathan K....Pearlson G.D. (2010)
    8. Association study of the serotoninergic system in mig raine in the Spanish population. (PubMed id 19455600)1, 4 Corominas R....Cormand B. (2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    10. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1644 HGNC: 2719 AceView: DDC Ensembl:ENSG00000132437 euGenes: HUgn1644
    ECgene: DDC Kegg: 1644 H-InvDB: DDC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDC Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DDC
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ddc/
    Wikipedia http://en.wikipedia.org/wiki/Aromatic-L-amino-acid_decarboxylase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDC gene:
    Search GeneIP for patents involving DDC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of DDC
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for DDC (Dopa Decarboxylase/DDC)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for DDC (Dopa Decarboxylase/DDC)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DDC   OriGene RNAi products in human, mouse, rat for DDC  
     OriGene qPCR primer pairs and template standards for DDC   OriGene Protein Over-expression Lysate for DDC  
     OriGene MassSpec something-or-other for DDC   OriGene clones in human, mouse for DDC  
     OriGene qSTAR qPCR primer pairs in human, mouse for DDC   OriGene Purified Protein for DDC  
     OriGene ORF clones in mouse, rat for DDC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDC   OriGene Custom Protein Services for DDC  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDC
     QIAGEN SeqTarget long-range PCR primers for resequencing DDC
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDC
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDC
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDC
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDC
     GenScript Custom Purified and Recombinant Proteins Services for DDC GenScript cDNA clones with any tag delivered in your preferred vector for DDC
     GenScript Custom Assay Services for DDC GenScript Custom Superior Antibodies Services for DDC
     GenScript Custom overexpressing Cell Line Services for DDC CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for DDC 

     Regulatory tfbs in DDC promoter
     Search Chromatin IP Primers for DDC
     RT2 qPCR Primer Assay in human, mouse, rat DDC
     GNC Network for DDC
     SABiosciences PCR Arrays including human, mouse, rat DDC
     Tocris compounds for DDC
     Proteins and Antibodies for DDC
     Cell Lysates for DDC
     cDNA Clones for DDC
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for DDC
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DDC antibodies
     DDC proteins
     DDC lysates
     Antibodies for DDC
     See all of Abcam's Antibodies, Kits and Proteins for DDC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DDC




     Proteins for DDC
     Antibodies for DDC
     ELISAs for DDC
     CLIAs for DDC
     Search LifeMap BioReagents cell lines for DDC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDC
     SwitchGear 3'UTR luciferase reporter plasmids for DDC
     SwitchGear Promoter luciferase reporter plasmids for DDC
     ThermoFisher Antibody for DDC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDC
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DDC
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DDC
    Customized:
     lentivirus for stable overexpression of DDC
     lentivirus expression plasmids for stable overexpression of DDC
     adenovirus for overexpression of DDC
     LSBio Antibodies in human, mouse, rat for DDC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DDC gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4