Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DDB1 Gene

protein-coding   GIFtS: 65
GCID: GC11M061066

Damage-Specific DNA Binding Protein 1, 127kDa

(Previous name: damage-specific DNA binding protein 1 (127kD))
  See DDB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Damage-Specific DNA Binding Protein 1, 127kDa1 2     XPE-Binding Factor2 3
Xeroderma Pigmentosum Group E-Complementing Protein2 3     Damage-Specific DNA Binding Protein 1 (127kD)1
XAP-12 3     DDBA2
XAP12 3     UV-DDB12
XPE-BF2 3     XPCE2
DDB P127 Subunit2 3     XPE2
DNA Damage-Binding Protein A2 3     DNA Damage-Binding Protein 12
HBV X-Associated Protein 12 3     DDBa3
UV-Damaged DNA-Binding Factor2 3     XPCe3
UV-Damaged DNA-Binding Protein 12 3     Damage-Specific DNA-Binding Protein 13
UV-DDB 12 3     

External Ids:    HGNC: 27171   Entrez Gene: 16422   Ensembl: ENSG000001679867   OMIM: 6000455   UniProtKB: Q165313   

Export aliases for DDB1 gene to outside databases

Previous GC identifers: GC11P063499 GC11M062579 GC11M061317 GC11M060842 GC11M060823 GC11M057394


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DDB1 Gene:
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex
while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair
and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients
with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by
photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether
the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform
mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene
are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule
for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and
the ubiquitination of proteins. (provided by RefSeq, May 2012)

GeneCards Summary for DDB1 Gene:
DDB1 (damage-specific DNA binding protein 1, 127kDa) is a protein-coding gene. Diseases associated with DDB1 include photosensitive trichothiodystrophy, and xeroderma pigmentosum. GO annotations related to this gene include damaged DNA binding. An important paralog of this gene is SF3B3.

UniProtKB/Swiss-Prot: DDB1_HUMAN, Q16531
Function: Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB
complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision
repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane
pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to
function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which
mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity
of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component
recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate
histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may
facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC,
which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination
of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA
replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a
role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2

Gene Wiki entry for DDB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDB1 gene promoter:
         NF-1   STAT3   CUTL1   Tal-1beta   ITF-2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDB1 promoter sequence
   Search Chromatin IP Primers for DDB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12-q13   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12-q13

DDB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDB1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M061066:  view genomic region     (about GC identifiers)

Start:
61,066,919 bp from pter      End:
61,110,068 bp from pter
Size:
43,150 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DDB1_HUMAN, Q16531 (See protein sequence)
Recommended Name: DNA damage-binding protein 1  
Size: 1140 amino acids; 126968 Da
Subunit: Component of the UV-DDB complex which includes DDB1 and DDB2. The UV-DDB complex interacts with
monoubiquitinated histone H2A and binds to XPC via the DDB2 subunit. Component of numerous DCX (DDB1-CUL4-X-box)
E3 ubiquitin-protein ligase complexes which consist of a core of DDB1, CUL4A or CUL4B and RBX1. DDB1 may recruit
specific substrate targeting subunits to the DCX complex. These substrate targeting subunits are generally known
as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Interacts with
AMBRA1, ATG16L1, BTRC, DCAF1, DCAF17, DCAF16, DCAF15, DDA1, DET1, DTL, ERCC8, FBXW5, FBXW8, GRWD1, DCAF6, KATNB1,
NLE1, NUP43, PAFAH1B1, PHIP, PWP1, RBBP4, RBBP5, RBBP7, RFWD2, SNRNP40, VPRBP, WDR5, WDR5B, WDR12, DCAF4, DCAF5,
DCAF11, WDR26, DCAF10, WDR39, DCAF12, WDR42, DCAF8, WDR53, WDR59, WDR61, DCAF7, WSB1, WSB2, LRWD1 and WDTC1. DCX
complexes may associate with the COP9 signalosome, and this inhibits the E3 ubiquitin-protein ligase activity of
the complex. Interacts with NF2, TSC1 and TSC2. Interacts with Simian virus 5 protein V and the HBV X protein.
Interaction with SV5 protein V may prevent the recruitment of DCAF proteins to DCX complexes. Interacts with AGO1
and AGO2. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and VPRBP proteins (EDVP
complex). Interacts directly with DYRK2. DCX(DTL) complex interacts with FBXO11; does not ubiquitinate and
degradate FBXO11
Selected PDB 3D structures from and Proteopedia for DDB1 (see all 27):
2B5L (3D)        2B5M (3D)        2B5N (3D)        2HYE (3D)        3E0C (3D)        3EI1 (3D)    
Secondary accessions: A6NG77 B2R648 O15176 Q13289 Q58F96

Explore the universe of human proteins at neXtProt for DDB1: NX_Q16531

Explore proteomics data for DDB1 at MOPED

Post-translational modifications: 

  • Phosphorylated by ABL1 (By similarity)1
  • Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin-dependent proteolysis1
  • Ubiquitination2 at Lys92, Lys141, Lys153, Lys191, Lys298, Lys383, Lys408, Lys484, Lys570, Lys579,
                                 Lys723, Lys823, Lys857, Lys897, Lys917, Lys936, Lys1067, Lys1081, Lys1121, Lys1131
  • Modification sites at PhosphoSitePlus

  • See DDB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001914.3  
    ENSEMBL proteins: 
     ENSP00000301764   ENSP00000399813   ENSP00000440269   ENSP00000441522   ENSP00000439787  
     ENSP00000445844   ENSP00000444650   ENSP00000442732   ENSP00000437713   ENSP00000445563  
     ENSP00000446044   ENSP00000442660   ENSP00000445554   ENSP00000441825   ENSP00000444105  
     ENSP00000440660   ENSP00000388705  
    Reactome Protein details: Q16531

    DDB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DDB1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DDB1
    GenScript Custom Purified and Recombinant Proteins Services for DDB1
    Novus Biologicals DDB1 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDB1

     
    Search eBioscience for Proteins for DDB1 

     
    antibodies-online proteins for DDB1 (4 products) 

     
    antibodies-online peptides for DDB1

    DDB1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DDB1 
    OriGene Antibodies for DDB1
    OriGene Custom Antibody Services for DDB1
    Novus Biologicals DDB1 Antibodies
    Abcam antibodies for DDB1
    Cloud-Clone Corp. Antibodies for DDB1
    ThermoFisher Antibody for DDB1
    antibodies-online antibodies for DDB1 

    DDB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DDB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DDB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDB1
    Cloud-Clone Corp. CLIAs for DDB1
    Search eBioscience for ELISAs for DDB1 
    antibodies-online kits for DDB1 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR004871 Cleavage/polyA-sp_fac_asu_C
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q16531

    ProtoNet protein and cluster: Q16531

    1 Blocks protein domain: IPB004871 CPSF A subunit C-terminal

    UniProtKB/Swiss-Prot: DDB1_HUMAN, Q16531
    Similarity: Belongs to the DDB1 family


    Find genes that share domains with DDB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDB1_HUMAN, Q16531
    Function: Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB
    complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision
    repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane
    pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to
    function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which
    mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity
    of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component
    recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate
    histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may
    facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC,
    which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination
    of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA
    replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a
    role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2

         Genatlas biochemistry entry for DDB1:
    damage specific DNA binding protein 1,p127 subunit,absent from cell strains from a minority of individuals with
    XP-E,possibly involved in nucleotide excision repair

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding TAS8798680
    GO:0003684damaged DNA binding TAS8407967
    GO:0003824catalytic activity ----
    GO:0005515protein binding IPI12732143
         
    Find genes that share ontologies with DDB1           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for DDB1:
     Decreased cell number, increas  Decreased homologous recombina  Decreased nuclei size in G2M  Decreased number of cells in m 
     Decreased viability of wild-ty  Increased circadian rhythm amp  Increased gamma-H2AX phosphory  S arrest 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ddb1):
     cardiovascular system  cellular  mortality/aging  nervous system  vision/eye 

    Find genes that share phenotypes with DDB1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ddb1tm1.1Spg for DDB1

       genOway: Develop your customized and physiologically relevant rodent model for DDB1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDB1:
    hsa-mir-3200-3p (MIRT052820), hsa-mir-149-5p (MIRT045485), hsa-mir-193b-3p (MIRT016411), hsa-mir-26a-5p (MIRT050184), hsa-mir-30c-5p (MIRT047942), hsa-mir-941 (MIRT036583), hsa-mir-186-5p (MIRT045270)

    Block miRNA regulation of human, mouse, rat DDB1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DDB1:
    hsa-miR-138-1* hsa-miR-548a-3p hsa-miR-548e hsa-miR-323-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidDDB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDB1
    Predesigned siRNA for gene silencing in human, mouse, rat DDB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DDB1

    Clone
    Products:
         
    OriGene clones in human, mouse for DDB1 (see all 7)
    OriGene ORF clones in mouse, rat for DDB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDB1 (NM_001923)
    Sino Biological Human cDNA Clone for DDB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDB1
    Addgene plasmids for DDB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DDB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DDB1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DDB1_HUMAN, Q16531: Cytoplasm. Nucleus. Note=Primarily cytoplasmic. Translocates to the nucleus following UV
    irradiation and subsequently accumulates at sites of DNA damage
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IDA18593899
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA18593899
    GO:0031464Cul4A-RING ubiquitin ligase complex IDA12732143

    Find genes that share ontologies with DDB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DDB1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Global Genomic NER (GG-NER)
    Global Genomic NER (GG-NER)0.69
    Dual incision reaction in GG-NER0.62
    Nucleotide excision repair0.69
    Formation of incision complex in GG-NER0.62
    2DNA Repair
    Nucleotide Excision Repair0.90
    DNA Repair0.45
    3Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35
    4Cell Cycle / Checkpoint Control
    DNA Damage0.32
    5Toll-like receptor signaling pathway
    Hepatitis B0.31


    Find genes that share SuperPaths with DDB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for DDB1
        DNA Damage
    Protein Stability


    2 Reactome Pathways for DDB1
        Formation of incision complex in GG-NER
    Dual incision reaction in GG-NER


    4 Kegg Pathways  (Kegg details for DDB1):
        Nucleotide excision repair
    Ubiquitin mediated proteolysis
    Hepatitis B
    Viral carcinogenesis

    UniProtKB/Swiss-Prot: DDB1_HUMAN, Q16531
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DDB1: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DDB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDB1 (Q165311, 2, 3 ENSP000003017644) via UniProtKB, MINT, STRING, and/or I2D (see all 991)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000718nucleotide-excision repair, DNA damage removal TAS--
    GO:0006281DNA repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0016032viral process IEA--
    GO:0016055Wnt signaling pathway IEA--

    Find genes that share ontologies with DDB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDB1

    1 HMDB Compound for DDB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Pyrimidine1,3-Diazabenzene (see all 10)25247-63-6--

    3 Novoseek inferred chemical compound relationships for DDB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cisplatin 18.8 5 2333286 (3), 2201976 (1), 8252487 (1)
    zinc 0 2 9740790 (1)
    cysteine 0 3 16112766 (1), 9740790 (1)



    Find genes that share compounds with DDB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DDB1 gene: 
    NM_001923.4  

    Unigene Cluster for DDB1:

    Damage-specific DNA binding protein 1, 127kDa
    Hs.290758  [show with all ESTs]
    Unigene Representative Sequence: NM_001923
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000301764(uc001nrc.4 uc010rle.1 uc001nrd.2 uc009ynl.1)
    ENST00000451943 ENST00000545894 ENST00000540166(uc010rlf.1) ENST00000538470
    ENST00000539332 ENST00000543658 ENST00000535147 ENST00000537877 ENST00000414411
    ENST00000535967 ENST00000539739 ENST00000540784 ENST00000538280 ENST00000545930(uc010rlg.1)
    ENST00000535174 ENST00000539712 ENST00000541513
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDB1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DDB1:
    hsa-miR-138-1* hsa-miR-548a-3p hsa-miR-548e hsa-miR-323-5p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidDDB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDB1
    Predesigned siRNA for gene silencing in human, mouse, rat DDB1
    Clone
    Products:
         
    OriGene clones in human, mouse for DDB1 (see all 7)
    OriGene ORF clones in mouse, rat for DDB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDB1 (NM_001923)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDB1
    Addgene plasmids for DDB1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DDB1
    OriGene qSTAR qPCR primer pairs in human, mouse for DDB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDB1
      QuantiTect SYBR Green Assays in human, mouse, rat DDB1
      QuantiFast Probe-based Assays in human, mouse, rat DDB1

    Additional mRNA sequence: 

    AJ002955.1 AK294341.1 AK294493.1 AK302924.1 AK303032.1 AK311112.1 AK311476.1 AK312436.1 
    BC011686.2 BC021044.1 BC032080.1 BC050530.1 BC051764.2 L40326.1 U18299.1 U32986.1 

    Selected DOTS entries (see all 48):

    DT.100887611  DT.100887618  DT.92463405  DT.97808133  DT.95139100  DT.87017915  DT.95082821  DT.95244963 
    DT.100887634  DT.120694269  DT.100887610  DT.120694373  DT.87017916  DT.100887613  DT.120694240  DT.120694233 
    DT.95138822  DT.99963513  DT.99999519  DT.100887633  DT.120694209  DT.120694248  DT.450673  DT.95138964 

    Selected AceView cDNA sequences (see all 1044):

    BG008638 BI256199 AU140418 AI868981 AI354776 BE302344 BU154345 CD368560 
    BU685166 BG751027 AI129611 AA315928 BM710668 BQ642180 BM927667 BF980710 
    BE386091 AI862879 BM469013 BQ642770 AI919339 BM474381 BQ447288 BE255880 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DDB1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                    -           -                                                                                                                           
    SP2:                                -                                                                                                                           
    SP3:                                                                                                                                -     -     -     -     -   
    SP4:        -           -           -                                                                                                                           
    SP5:                    -           -     -     -                                                                                                               

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b · 26c · 26d ^ 27a · 27b · 27c · 27d · 27e ^ 28 ^ 29a · 29b
    SP1:              -                                   -                                             
    SP2:                                                                                                
    SP3:  -     -     -     -     -                       -                                             
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for DDB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DDB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTAGCCTGG
    DDB1 Expression
    About this image


    DDB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
    DDB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.290758
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DDB1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDB1
    OriGene qSTAR qPCR primer pairs in human, mouse for DDB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDB1
    QuantiTect SYBR Green Assays in human, mouse, rat DDB1
    QuantiFast Probe-based Assays in human, mouse, rat DDB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DDB1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddb11 , 5 damage specific DNA binding protein 11, 5 90.7(n)1
    99.65(a)1
      19 (6.66 cM)5
    131941  NM_015735.11  NP_056550.11 
     106056255 
    chicken
    (Gallus gallus)
    Aves DDB11 damage-specific DNA binding protein 1, 127kDa 83.77(n)
    97.11(a)
      374050  NM_204216.2  NP_989547.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDB16
    damage-specific DNA binding protein 1, 127kDa
    97(a)
    1 ↔ 1
    GL343235.1(747177-783410)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC684762 hypothetical protein MGC68476 78.85(n)    BC061946.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638402 hypothetical protein MGC63840 78.83(n)   393599  BC056837.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta DDB13
    pic1
    nucleotide-excision repair damaged DNA
    binding3
    piccolo1
    60(a)3
    60.42(n)1
    61.27(a)1
      87D113
    416111  NM_142000.31  NP_650257.11 
    worm
    (Caenorhabditis elegans)
    Secernentea M18.53 DNA repair protein like 37(a)   IV(12115373-12121295)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RSE16
    Protein involved in pre-mRNA splicing; component o...
    14(a)
    1 → many
    XIII(174220-178305) YML049C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons DDB1A1 DDB1A 55.67(n)
    55.89(a)
      825890  NM_116781.2  NP_192451.1 
    rice
    (Oryza sativa)
    Liliopsida Os.4192 Oryza sativa (japonica cultivar-group) OsUV-DDB mRNA more 73.64(n)    AK065508.1 


    ENSEMBL Gene Tree for DDB1 (if available)
    TreeFam Gene Tree for DDB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DDB1 gene
    SF3B32  

    Find genes that share paralogs with DDB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DDB1 (see all 895)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887595761,2
    --57412273(+) ATATAC/TATATA 1 -- int10--------
    rs1818653401,2
    --57412285(+) ATATAG/TATATA 1 -- int10--------
    rs745714511,2
    C--57415834(+) TACTTT/CTTTTT 1 -- int13Minor allele frequency- C:0.23WA CSA 121
    rs611882381,2
    C--57425728(+) AAAGA-/GGAAAA 1 -- int12Minor allele frequency- G:0.25NA CSA 4
    rs2017428251,2
    C--57425728(+) AAAGAA/GGAAAA 1 -- int10--------
    rs287202561,2
    F--57425729(-) TTTTT-/TTCTCT 1 -- int1 trp35Minor allele frequency- T:0.07NS 186
    rs785584481,2
    F--60987169(+) GGGCAT/GGTGGC 1 -- int11Minor allele frequency- G:0.06WA 118
    rs1468903401,2
    C--60987304(+) GTTACC/TGACAG 1 -- int10--------
    rs287569681,2
    C--60987353(-) TCACTG/AGTCTT 1 -- int15Minor allele frequency- A:0.01NS 172
    rs112306601,2
    C,F,A,H--60987373(+) CCCATC/AATCCT 1 -- int120Minor allele frequency- A:0.10NS EA NA WA 1736

    HapMap Linkage Disequilibrium report for DDB1 (61066919 - 61110068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DDB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509415CNV Insertion20534489
    nsv832177CNV Loss17160897
    nsv428259CNV Gain+Loss18775914
    dgv390e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDB1
    DNA2.0 Custom Variant and Variant Library Synthesis for DDB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600045    OMIM disorders: --

    3 diseases for DDB1:    
    About MalaCards
    photosensitive trichothiodystrophy    xeroderma pigmentosum    vitelliform macular dystrophy

    3 diseases from the University of Copenhagen DISEASES database for DDB1:
    Xeroderma pigmentosum     Cockayne syndrome     Photosensitive trichothiodystrophy

    Find genes that share disorders with DDB1           About GenesLikeMe

    7 Novoseek inferred disease relationships for DDB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum, complementation group e 95.4 5 16260596 (1), 7523888 (1), 8538642 (1), 19382146 (1)
    xeroderma pigmentosum 87 8 9632823 (1), 7523888 (1), 12181326 (1), 19181111 (1) (see all 6)
    macular dystrophy, vitelliform 63.9 1 9781049 (1)
    parainfluenza 44.8 2 9740790 (1)
    hepatitis b 22.6 5 9020796 (2), 9740790 (1)
    cancer 18.5 1 16260596 (1)
    tumors 7.61 6 2333286 (2), 2201976 (1), 18324346 (1)


    Export disorders for DDB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DDB1 gene, integrated from 10 sources (see all 272):
    (articles sorted by number of sources associating them with DDB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein. (PubMed id 8530102)1, 2, 3 Dualan R.... Linn S. (Genomics 1995)
    2. DDB1 maintains genome integrity through regulation of Cdt1. (PubMed id 16940174)1, 2, 9 Lovejoy C.A.... Cortez D. (Mol. Cell. Biol. 2006)
    3. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. (PubMed id 15448697)1, 2, 9 Hu J.... Xiong Y. (Nat. Cell Biol. 2004)
    4. Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells. (PubMed id 8538642)1, 2, 9 Hwang B.J.... Chu G. (Mutat. Res. 1996)
    5. Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. (PubMed id 18606781)1, 2, 9 McCall C.M.... Xiong Y. (Mol. Cell. Biol. 2008)
    6. Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties. (PubMed id 16260596)1, 2, 9 Kulaksiz G.... Sancar A. (Mol. Cell. Biol. 2005)
    7. Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. (PubMed id 7815490)1, 2, 9 Lee T.H.... Butel J.S. (J. Virol. 1995)
    8. WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase. (PubMed id 18381890)1, 2, 9 Hu J....Xiong Y. (Genes Dev. 2008)
    9. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. (PubMed id 18593899)1, 2, 9 Guerrero-Santoro J.... Rapic-Otrin V. (Cancer Res. 2008)
    10. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2, 9 Jin J.... Walter J.C. (Mol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1642 HGNC: 2717 AceView: DDB1 Ensembl:ENSG00000167986 euGenes: HUgn1642
    ECgene: DDB1 Kegg: 1642 H-InvDB: DDB1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DDB1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DDB1 Genetics and Cytogenetics in Oncology and Haematology
    Allelic variations of the XP geneshttp://www.xpmutations.org/
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ddb1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DDB1 gene:
    Search GeneIP for patents involving DDB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DDB1   OriGene RNAi products in human, mouse, rat for DDB1  
     OriGene qPCR primer pairs and template standards for DDB1   OriGene Protein Over-expression Lysate for DDB1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DDB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DDB1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DDB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DDB1   OriGene Custom Protein Services for DDB1  

     
     
     Block miRNA regulation of human, mouse, rat DDB1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DDB1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDB1 Predesigned siRNA for gene silencing in human, mouse, rat DDB1
     QuantiFast Probe-based Assays in human, mouse, rat DDB1 QuantiTect SYBR Green Assays in human, mouse, rat DDB1
     PCR Arrays including human, mouse, rat DDB1 Search Chromatin IP Primers for DDB1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDB1  GeneGlobe Interaction Network for DDB1
     Regulatory tfbs in DDB1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DDB1 GenScript cDNA clones with any tag delivered in your preferred vector for DDB1
     GenScript Custom Assay Services for DDB1 GenScript Custom overexpressing Cell Line Services for DDB1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for DDB1 

     Search Tocris compounds for DDB1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DDB1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DDB1 antibodies
     DDB1 proteins
     Antibodies for DDB1
     See all of Abcam's Antibodies, Kits and Proteins for DDB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DDB1
     Antibodies for DDB1
     ELISAs for DDB1
     CLIAs for DDB1



     Browse ESI BIO Cell Lines and PureStem Progenitors for DDB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDB1
     SwitchGear 3'UTR luciferase reporter plasmids for DDB1
     SwitchGear Promoter luciferase reporter plasmids for DDB1
     ThermoFisher Antibody for DDB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDB1
     Browse compounds at ApexBio
     Addgene plasmids for DDB1
      Search eBioscience for proteins for DDB1
      Search eBioscience for elisas for DDB1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DDB1
     antibodies-online antibodies for DDB1
     antibodies-online kits for DDB1 (10 products)
     antibodies-online peptides for DDB1
     antibodies-online proteins for DDB1 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DDB1 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4