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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDAH2 Gene

protein-coding   GIFtS: 60
GCID: GC06M031694

Dimethylarginine Dimethylaminohydrolase 2

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dimethylarginine Dimethylaminohydrolase 21 2 3     G6a2
Protein G6a2 3     Alternative Name: NG30, G6a2
DDAH2 3     dimethylargininase-22
DDAH-22 3     Dimethylarginine Dimethylaminohydrolase II2
DDAHII2 3     N(G),N(G)-Dimethylarginine Dimethylaminohydrolase 22
NG302 3     NG-Dimethylarginine Dimethylamino Hydrolase Homolog2
S-Phase Protein2 3     Dimethylargininase-23
EC 3.5.3.183 8     G6A3

External Ids:    HGNC: 27161   Entrez Gene: 235642   Ensembl: ENSG000002137227   OMIM: 6047445   UniProtKB: O958653   

Export aliases for DDAH2 gene to outside databases

Previous GC identifers: GC06M031758 GC06M031465 GC06M031799 GC06M031803 GC06M031481


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DDAH2 Gene:
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a
role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit
nitric oxide synthase activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDAH2 Gene: 
DDAH2 (dimethylarginine dimethylaminohydrolase 2) is a protein-coding gene. Diseases associated with DDAH2 include asphyxiating thoracic dystrophy, and cytomegalovirus infection. GO annotations related to this gene include dimethylargininase activity and catalytic activity. An important paralog of this gene is DDAH1.

UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865
Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as
inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  NT_167249.1  
NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDAH2 gene promoter:
         AREB6   Sp1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): DDAH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDAH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDAH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

DDAH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDAH2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031694:  view genomic region     (about GC identifiers)

Start:
31,694,815 bp from pter      End:
31,698,394 bp from pter
Size:
3,580 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167245 2,980,386-2,983,608      Chr6-,NT_113891.2 3,204,434-3,207,656      Chr6-,NT_167247 3,074,500-3,077,722     
Chr6-,NT_167246 3,037,707-3,040,929      Chr6-,NT_167249 3,025,634-3,028,856      Chr6-,NT_167248 2,988,447-2,991,669     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865 (See protein sequence)
Recommended Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 2  
Size: 285 amino acids; 29644 Da
Subcellular location: Cytoplasm. Mitochondrion. Note=Translocates from cytosol to mitochondrion upon IL-1beta
stimulation in chondrocytes
Secondary accessions: A2BEZ7

Explore the universe of human proteins at neXtProt for DDAH2: NX_O95865

Explore proteomics data for DDAH2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95865

  • 4/5 DME Specific Peptides for DDAH2 (O95865) (see all 5)
     AVSTVPV  DENATLDG  DVLFTGREFFVGLSK  SHLRGLCGMGGPRTVVAGSS 

    DDAH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DDAH2 Protein Expression
    REFSEQ proteins: NP_039268.1  
    ENSEMBL proteins: 
     ENSP00000413164   ENSP00000364945   ENSP00000364943   ENSP00000364949   ENSP00000397466  
     ENSP00000395759  

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    Cloud-Clone Corp. Proteins for DDAH2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--

    DDAH2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: NG,NG-Dimethylarginine dimethylaminohydrolase 2 
    Dimethylarginine dimethylaminohydrolases

    1 InterPro protein domain:
     IPR003198 Amidino_trans

    Graphical View of Domain Structure for InterPro Entry O95865

    ProtoNet protein and cluster: O95865

    1 Blocks protein domain: IPB003198 Amidinotransferase

    UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865
    Similarity: Belongs to the DDAH family


    DDAH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDAH2_HUMAN, O95865
    Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as
    inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation
    Catalytic activity: N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline

         Genatlas biochemistry entry for DDAH2:
    N-omega,N-omega dimethylarginine dimethylaminohydrolase,endogenous inhibitor of nitric oxide synthesis,encoded by
    G6A,member of MHC3

         Enzyme Number (IUBMB): EC 3.5.3.181 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS10493931
    GO:0005515protein binding IPI16189514
    GO:0016403dimethylargininase activity IDA10493931
    GO:0016597amino acid binding IEA--
    GO:0016813hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines ----
         
    DDAH2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DDAH2:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Ddah2):
     mortality/aging 

    DDAH2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ddah2tm1Roab for DDAH2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DDAH2 
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    SwitchGear 3'UTR luciferase reporter plasmidDDAH2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDAH2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/23 Interacting proteins for DDAH2 (O958651, 2, 3 ENSP000003649434) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271036 I2D: score=2 
    SMN2Q166372, 3MINT-8271036 I2D: score=2 
    ANXA7P200732, 3MINT-8248252 I2D: score=2 
    ATP1B1P050262, 3MINT-8249135 I2D: score=2 
    CDC73Q6P1J92, 3MINT-8251087 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000052citrulline metabolic process IDA10493931
    GO:0006525arginine metabolic process ----
    GO:0006527arginine catabolic process TAS10493931
    GO:0006809nitric oxide biosynthetic process TAS10493931
    GO:0007263nitric oxide mediated signal transduction TAS10493931

    DDAH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DDAH2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDAH2

    4 HMDB Compounds for DDAH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Citrulline(2S)-2-amino-5-(carbamoylamino)pentanoic acid (see all 55)372-75-8--
    Dimethyl-L-arginine2-amino-5-(amino-dimethylamino-methylidene)amino-pentanoate (see all 9)102783-24-4--
    DimethylamineDimethylamine (see all 10)124-40-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for DDAH2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--10950934 17653133

    10/26 Novoseek inferred chemical compound relationships for DDAH2 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adma 97.5 272 20209122 (8), 17141242 (6), 18342305 (6), 16897158 (5) (see all 91)
    demethylbellidifolin 85.3 2 15234768 (1)
    n(g),n(g)-dimethylarginine 84.8 3 16472125 (1), 8982498 (1), 19682580 (1)
    dimethylamine 82.8 7 19682581 (1), 16702618 (1), 14664899 (1), 11168975 (1) (see all 7)
    citrulline 80.8 18 17205823 (2), 17653133 (2), 10377069 (1), 8982498 (1) (see all 15)
    nitric oxide 77.8 91 18167189 (6), 12370443 (6), 18342305 (5), 17097077 (3) (see all 34)
    arginine 74 26 17075694 (2), 11473257 (2), 16897158 (1), 16358064 (1) (see all 19)
    2,4-dichlorophenoxyacetic acid 73 10 18292189 (2), 17977009 (1), 19178698 (1), 14664899 (1) (see all 6)
    xanthone 63.2 3 14604680 (2)
    lysophosphatidylcholine 53.7 15 18342305 (4), 16309971 (3), 16897158 (1), 12750878 (1)

    Search CenterWatch for drugs/clinical trials and news about DDAH2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DDAH2 gene: 
    NM_013974.1  

    Unigene Cluster for DDAH2:

    Dimethylarginine dimethylaminohydrolase 2
    Hs.247362  [show with all ESTs]
    Unigene Representative Sequence: BM460795
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437288 ENST00000469963 ENST00000375789(uc003nwp.3) ENST00000480913
    ENST00000483792 ENST00000375787 ENST00000375792(uc003nwq.3) ENST00000416410
    ENST00000436437 ENST00000488119
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate DDAH2:
    hsa-miR-3130-5p
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    Additional mRNA sequence: 

    AF070667.1 AF087894.1 AK026191.1 AK098671.1 AK310024.1 BC001435.2 

    13 DOTS entries:

    DT.100820948  DT.100820945  DT.448917  DT.100820947  DT.102841783  DT.95153733  DT.97768715  DT.100820952 
    DT.121408303  DT.91769251  DT.121408228  DT.91769254  DT.91769255 

    24/1684 AceView cDNA sequences (see all 1684):

    BM829930 BM832075 BU627322 CR622923 CB109671 CR613259 BM809147 BM769104 
    BQ217079 BM763365 CR596711 BE349449 BM981100 CR624716 AI343691 CR542071 
    BU617961 AA330292 CB113843 CB242623 BE273418 CD370803 BQ219435 BM765793 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDAH2 expression in normal human tissues (normalized intensities)      DDAH2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGACCTC
    DDAH2 Expression
    About this image


    DDAH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
             superior temporal gyrus   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   

    See DDAH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDAH2

    SOURCE GeneReport for Unigene cluster: Hs.247362

    UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865
    Tissue specificity: Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very
    low levels in brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including DDAH2: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDAH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DDAH2 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddah21 , 5 dimethylarginine dimethylaminohydrolase 21, 5 89.44(n)1
    97.54(a)1
      17 (18.59 cM)5
    517931  NM_001190449.11  NP_001177378.11 
     350590355 
    lizard
    (Anolis carolinensis)
    Reptilia DDAH26
    dimethylarginine dimethylaminohydrolase 2
    52(a)
    1 ↔ 1
    GL343570.1(332689-381570)
    zebrafish
    (Danio rerio)
    Actinopterygii ddah21 dimethylarginine dimethylaminohydrolase 2 55.97(n)
    50.92(a)
      799954  NM_001100065.2  NP_001093535.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG17643 dimethylargininase 33(a)   11E9   --


    ENSEMBL Gene Tree for DDAH2 (if available)
    TreeFam Gene Tree for DDAH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDAH2 gene
    DDAH12  
    1 SIMAP similar gene for DDAH2 using alignment to 5 protein entries:     DDAH2_HUMAN (see all proteins):
    DDAH1

    DDAH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/44 SNPs in DDAH2 are shown (see all 44)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454476271,2
    C,F--31695043(+) CACCAA/GGCAGA 2 L syn12Minor allele frequency- G:0.00NA EU 5733
    rs115403211,2
    C,F,H--31695368(+) AAAGGG/AGGCAC 2 /P syn15Minor allele frequency- A:0.09NS NA EU 6379
    rs2001262041,2
    C,F--31695391(+) AGGACG/AAAGAA 2 /R /C mis11Minor allele frequency- A:0.00EU 1323
    rs1389079401,2
    C,F--31695437(+) AGGGAG/AGCATA 2 /A syn12Minor allele frequency- A:0.00NA EU 5865
    rs283661621,2
    C,F,H--31695590(+) GCACAT/CAGAGC 1 -- int112Minor allele frequency- C:0.09NS NA WA 1704
    rs69125151,2
    C,H--31696070(+) AAGTCC/TTAGGG 1 -- spa14Minor allele frequency- T:0.00NS EA 416
    rs1508321841,2
    C--31696235(+) GGAACG/ATGTCC 2 /T /M mis11Minor allele frequency- A:0.00NA 3666
    rs1390068701,2
    C,F--31696321(+) CCGCGG/AAGGTT 1 -- int11Minor allele frequency- A:0.01EU 1153
    rs1137694251,2
    C,F--31696394(+) CTGTGG/CCAAGA 1 -- int12Minor allele frequency- C:0.50CSA 4
    rs117524931,2
    C,F,H--31696413(+) TCCCCC/GCAGCC 1 -- int12Minor allele frequency- G:0.01CSA EU 1313

    HapMap Linkage Disequilibrium report for DDAH2 (31694815 - 31698394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DDAH2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv349349CNV Loss16902084
    nsv349350CNV Loss16902084
    nsv884425CNV Loss21882294
    nsv884418CNV Gain21882294


    Human Gene Mutation Database (HGMD): DDAH2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DDAH2
    DNA2.0 Custom Variant and Variant Library Synthesis for DDAH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604744    OMIM disorders: --

    20 diseases for DDAH2:    About MalaCards
    asphyxiating thoracic dystrophy    cytomegalovirus infection    arteriosclerosis    hypercholesterolemia
    pre-eclampsia    eclampsia    hypertension    atherosclerosis
    hyperglycemia    essential hypertension    endotheliitis    kidney disease
    diabetes mellitus    type 1 diabetes    systemic lupus erythematosus    lupus erythematosus
    hypoxia    cerebritis    hepatitis    breast cancer


    DDAH2 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for DDAH2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiovascular diseases 51.6 2 14550280 (1), 20219849 (1)
    atherosclerosis 41 2 17293168 (1), 18991678 (1), 17368960 (1)
    preeclampsia 35.6 11 18251679 (3), 19570459 (2), 15501905 (1), 16508323 (1)
    renal failure chronic 33.3 1 16932427 (1)
    diabetes mellitus 18.4 3 19775692 (2)
    necrosis 18.2 4 10377069 (1), 14604680 (1), 14750034 (1), 11168975 (1)
    hypercholesterolemia 11.5 2 10377069 (1), 17293168 (1)
    stroke 0 1 19250061 (1)
    hypertension pulmonary 0 2 12615801 (1), 15827267 (1)
    tumors 0 4 10377069 (1), 14604680 (1), 14750034 (1), 11168975 (1)

    Genetic Association Database (GAD): DDAH2
    Human Genome Epidemiology (HuGE) Navigator: DDAH2 (14 documents)

    Export disorders for DDAH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDAH2 gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with DDAH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. (PubMed id 10493931)1, 2, 3, 9 Leiper J.M.... Vallance P. (1999)
    2. Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. (PubMed id 10950934)1, 7, 9 Tran C.T....Leiper J.M. (2000)
    3. Common genetic variation in DDAH2 is associated with intracerebral hemorrhage in Chinese population: a multicenter case-control study in China. (PubMed id 19250061)1, 4, 9 Bai Y....Hui R. (2009)
    4. Sequence variation in DDAH1 and DDAH2 genes is strong ly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. (PubMed id 20209122)1, 4, 9 Abhary S....Craig J.E. (2010)
    5. Polymorphisms in the promoter region of the dimethyla rginine dimethylaminohydrolase 2 gene are associated with prevalence of hyperte nsion. (PubMed id 19666123)1, 4, 9 Maas R....Lieb W. (2009)
    6. Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study. (PubMed id 17002794)1, 4, 9 O'Dwyer M.J....Ryan T. (2006)
    7. Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 p olymorphisms. (PubMed id 20010544)1, 4, 9 Caplin B....Leiper J.M. (2010)
    8. Dimethylarginine dimethylaminohydrolase 2, a newly ide ntified mitochondrial protein modulating nitric oxide synthesis in normal human chondrocytes. (PubMed id 21898353)1, 2 Cillero-Pastor B....Blanco F.J. (2012)
    9. Assessment of serum levels of asymmetric dimethylargi nine, symmetric dimethylarginine and L-arginine in coronary artery disease. (PubMed id 20936901)1, 4 Gad M.Z....Elgabarty H.A. (2010)
    10. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23564 HGNC: 2716 AceView: CLIC1 Ensembl:ENSG00000213722 euGenes: HUgn23564
    ECgene: DDAH2 H-InvDB: DDAH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDAH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DDAH2 gene:
    Search GeneIP for patents involving DDAH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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