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DDAH2 Gene

protein-coding   GIFtS: 59
GCID: GC06M031694

Dimethylarginine Dimethylaminohydrolase 2

  Search for DDAH2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dimethylarginine Dimethylaminohydrolase 21 2 3     HEL-S-2772
Protein G6a2 3     Alternative Name: NG30, G6a2
DDAH2 3     dimethylargininase-22
DDAH-22 3     Dimethylarginine Dimethylaminohydrolase II2
DDAHII2 3     Epididymis Secretory Protein Li 2772
NG302 3     N(G),N(G)-Dimethylarginine Dimethylaminohydrolase 22
S-Phase Protein2 3     NG-Dimethylarginine Dimethylamino Hydrolase Homolog2
EC 3.5.3.183 8     Dimethylargininase-23
G6a2     G6A3

External Ids:    HGNC: 27161   Entrez Gene: 235642   Ensembl: ENSG000002137227   OMIM: 6047445   UniProtKB: O958653   

Export aliases for DDAH2 gene to outside databases

Previous GC identifers: GC06M031758 GC06M031465 GC06M031799 GC06M031803 GC06M031481


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDAH2 Gene:
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a
role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit
nitric oxide synthase activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDAH2 Gene:
DDAH2 (dimethylarginine dimethylaminohydrolase 2) is a protein-coding gene. GO annotations related to this gene include dimethylargininase activity and amino acid binding. An important paralog of this gene is DDAH1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  NT_167249.2  
NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDAH2 gene promoter:
         AREB6   Sp1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): DDAH2 promoter sequence
   Search Chromatin IP Primers for DDAH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDAH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

DDAH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDAH2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M031694:  view genomic region     (about GC identifiers)

Start:
31,694,815 bp from pter      End:
31,698,394 bp from pter
Size:
3,580 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_113891.2 3,204,434-3,207,656      Chr6-,NT_167249 3,025,634-3,028,856      Chr6-,NT_167246 3,037,707-3,040,929     
Chr6-,NT_167247 3,074,500-3,077,722      Chr6-,NT_167245 2,980,386-2,983,608      Chr6-,NT_167248 2,988,447-2,991,669     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDAH2_HUMAN, O95865 (See protein sequence)
Recommended Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 2  
Size: 285 amino acids; Da
Secondary accessions: A2BEZ7

Explore the universe of human proteins at neXtProt for DDAH2: NX_O95865

Explore proteomics data for DDAH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDAH2 (O95865) (see all 5)
     AVSTVPV  DENATLDG  DVLFTGREFFVGLSK  SHLRGLCGMGGPRTVVAGSS 


    See DDAH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_039268.1  
    ENSEMBL proteins: 
     ENSP00000413164   ENSP00000364945   ENSP00000364943   ENSP00000364949   ENSP00000397466  
     ENSP00000395759  

    DDAH2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DDAH2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DDAH2
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    Novus Biologicals DDAH2 Proteins
    Novus Biologicals DDAH2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DDAH2

     
    Search eBioscience for Proteins for DDAH2 

    DDAH2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for DDAH2
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    ThermoFisher Antibody for DDAH2
    LSBio Antibodies in human, mouse, rat for DDAH2

    DDAH2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DDAH2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DDAH2
    Cloud-Clone Corp. CLIAs for DDAH2
    Search eBioscience for ELISAs for DDAH2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: NG,NG-Dimethylarginine dimethylaminohydrolase 2
    Dimethylarginine dimethylaminohydrolases

    ProtoNet protein and cluster: O95865

    1 Blocks protein domain: IPB003198 Amidinotransferase


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for DDAH2:
    N-omega,N-omega dimethylarginine dimethylaminohydrolase,endogenous inhibitor of nitric oxide synthesis,encoded by
    G6A,member of MHC3

         Enzyme Number (IUBMB): EC 3.5.3.181 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS10493931
    GO:0005515protein binding IPI16189514
    GO:0016403dimethylargininase activity IDA10493931
    GO:0016597amino acid binding IEA--
    GO:0016813hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines ----
         
    Find genes that share ontologies with DDAH2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DDAH2:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Ddah2):
     mortality/aging 

    Find genes that share phenotypes with DDAH2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ddah2tm1Roab for DDAH2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDAH2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DDAH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DDAH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DDAH2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DDAH2:
    hsa-mir-34a-5p (MIRT025565)

    Block miRNA regulation of human, mouse, rat DDAH2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DDAH2:
    hsa-miR-3130-5p
    SwitchGear 3'UTR luciferase reporter plasmidDDAH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DDAH2
    Predesigned siRNA for gene silencing in human, mouse, rat DDAH2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DDAH2

    Clone
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    OriGene clones in human, mouse for DDAH2 (see all 7)
    OriGene ORF clones in mouse, rat for DDAH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDAH2 (NM_013974)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDAH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDAH2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DDAH2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDAH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with DDAH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including DDAH2: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DDAH2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for DDAH2 (O958652, 3 ENSP000003649434) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMN1Q166372, 3MINT-8271036 I2D: score=2 
    SMN2Q166372, 3MINT-8271036 I2D: score=2 
    ANXA7P200732, 3MINT-8248252 I2D: score=2 
    ATP1B1P050262, 3MINT-8249135 I2D: score=2 
    CDC73Q6P1J92, 3MINT-8251087 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000052citrulline metabolic process IDA10493931
    GO:0006525arginine metabolic process ----
    GO:0006527arginine catabolic process TAS10493931
    GO:0006809nitric oxide biosynthetic process TAS10493931
    GO:0007263nitric oxide mediated signal transduction TAS10493931

    Find genes that share ontologies with DDAH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDAH2

    4 HMDB Compounds for DDAH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Citrulline(2S)-2-amino-5-(carbamoylamino)pentanoic acid (see all 55)372-75-8--
    Dimethyl-L-arginine2-amino-5-(amino-dimethylamino-methylidene)amino-pentanoate (see all 9)102783-24-4--
    DimethylamineDimethylamine (see all 10)124-40-3--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for DDAH2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--10950934 17653133

    Selected Novoseek inferred chemical compound relationships for DDAH2 gene (see all 26)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adma 97.5 272 20209122 (8), 17141242 (6), 18342305 (6), 16897158 (5) (see all 91)
    demethylbellidifolin 85.3 2 15234768 (1)
    n(g),n(g)-dimethylarginine 84.8 3 16472125 (1), 8982498 (1), 19682580 (1)
    dimethylamine 82.8 7 19682581 (1), 16702618 (1), 14664899 (1), 11168975 (1) (see all 7)
    citrulline 80.8 18 17205823 (2), 17653133 (2), 10377069 (1), 8982498 (1) (see all 15)
    nitric oxide 77.8 91 18167189 (6), 12370443 (6), 18342305 (5), 17097077 (3) (see all 34)
    arginine 74 26 17075694 (2), 11473257 (2), 16897158 (1), 16358064 (1) (see all 19)
    2,4-dichlorophenoxyacetic acid 73 10 18292189 (2), 17977009 (1), 19178698 (1), 14664899 (1) (see all 6)
    xanthone 63.2 3 14604680 (2)
    lysophosphatidylcholine 53.7 15 18342305 (4), 16309971 (3), 16897158 (1), 12750878 (1)



    Find genes that share compounds with DDAH2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDAH2 gene: 
    NM_013974.1  

    Unigene Cluster for DDAH2:

    Dimethylarginine dimethylaminohydrolase 2
    Hs.247362  [show with all ESTs]
    Unigene Representative Sequence: BM460795
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437288 ENST00000469963 ENST00000375789(uc003nwp.3) ENST00000480913
    ENST00000483792 ENST00000375787 ENST00000375792(uc003nwq.3) ENST00000416410
    ENST00000436437 ENST00000488119
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DDAH2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DDAH2:
    hsa-miR-3130-5p
    SwitchGear 3'UTR luciferase reporter plasmidDDAH2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DDAH2
    Predesigned siRNA for gene silencing in human, mouse, rat DDAH2
    Clone
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    OriGene clones in human, mouse for DDAH2 (see all 7)
    OriGene ORF clones in mouse, rat for DDAH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DDAH2 (NM_013974)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DDAH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDAH2
    Primer
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    OriGene qPCR primer pairs and template standards for DDAH2
    OriGene qSTAR qPCR primer pairs in human, mouse for DDAH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDAH2
      QuantiTect SYBR Green Assays in human, mouse, rat DDAH2
      QuantiFast Probe-based Assays in human, mouse, rat DDAH2

    Additional mRNA sequence: 

    AF070667.1 AF087894.1 AK026191.1 AK098671.1 AK310024.1 BC001435.2 

    13 DOTS entries:

    DT.100820948  DT.100820945  DT.448917  DT.100820947  DT.102841783  DT.95153733  DT.97768715  DT.100820952 
    DT.121408303  DT.91769251  DT.121408228  DT.91769254  DT.91769255 

    Selected AceView cDNA sequences (see all 1684):

    BM910588 BQ773342 BM986754 BM808624 CF527794 BX479253 CF527747 BM808153 
    H97066 BU159329 BU845424 N81116 CA848437 BQ691712 AI292229 AI242404 
    BI828473 BM798925 BI819181 CA426738 BM550884 BM842478 BG573922 AI343691 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDAH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGACCTC
    DDAH2 Expression
    About this image


    DDAH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cushion Mesenchymal Cells Endocardium
     
     Thymus (Hematopoietic System)
             Thymus
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
    DDAH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDAH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.247362
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DDAH2: 
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DDAH2
    OriGene qSTAR qPCR primer pairs in human, mouse for DDAH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DDAH2
    QuantiTect SYBR Green Assays in human, mouse, rat DDAH2
    QuantiFast Probe-based Assays in human, mouse, rat DDAH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDAH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DDAH2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddah21 , 5 dimethylarginine dimethylaminohydrolase 21, 5 89.44(n)1
    97.54(a)1
      17 (18.59 cM)5
    517931  NM_001190449.11  NP_001177378.11 
     350590355 
    lizard
    (Anolis carolinensis)
    Reptilia DDAH26
    dimethylarginine dimethylaminohydrolase 2
    53(a)
    1 ↔ 1
    GL343570.1(332689-381570)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ddah21 dimethylarginine dimethylaminohydrolase 2 60.78(n)
    59.4(a)
      448306  NM_001004924.1  NP_001004924.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ddah21 dimethylarginine dimethylaminohydrolase 2 55.85(n)
    51.12(a)
      799954  NM_001100065.2  NP_001093535.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG17643 dimethylargininase 33(a)   11E9   --


    ENSEMBL Gene Tree for DDAH2 (if available)
    TreeFam Gene Tree for DDAH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDAH2 gene
    DDAH12  
    1 SIMAP similar gene for DDAH2 using alignment to 4 protein entries:     DDAH2_HUMAN (see all proteins):
    DDAH1

    Find genes that share paralogs with DDAH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDAH2 (see all 44)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454476271,2
    C,F--31695043(+) CACCAA/GGCAGA 2 L syn12Minor allele frequency- G:0.00NA EU 5733
    rs115403211,2
    C,F,H--31695368(+) AAAGGG/AGGCAC 2 /P syn15Minor allele frequency- A:0.09NS NA EU 6379
    rs2001262041,2
    C,F--31695391(+) AGGACG/AAAGAA 2 /R /C mis11Minor allele frequency- A:0.00EU 1323
    rs1389079401,2
    C,F--31695437(+) AGGGAG/AGCATA 2 /A syn12Minor allele frequency- A:0.00NA EU 5865
    rs283661621,2
    C,F,H--31695590(+) GCACAT/CAGAGC 1 -- int112Minor allele frequency- C:0.09NS NA WA 1704
    rs69125151,2
    C,H--31696070(+) AAGTCC/TTAGGG 1 -- spa14Minor allele frequency- T:0.00NS EA 416
    rs1508321841,2
    C--31696235(+) GGAACG/ATGTCC 2 /T /M mis11Minor allele frequency- A:0.00NA 3666
    rs1390068701,2
    C,F--31696321(+) CCGCGG/AAGGTT 1 -- int11Minor allele frequency- A:0.01EU 1153
    rs1137694251,2
    C,F--31696394(+) CTGTGG/CCAAGA 1 -- int12Minor allele frequency- C:0.50CSA 4
    rs117524931,2
    C,F,H--31696413(+) TCCCCC/GCAGCC 1 -- int12Minor allele frequency- G:0.01CSA EU 1313

    HapMap Linkage Disequilibrium report for DDAH2 (31694815 - 31698394 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DDAH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv349349CNV Loss16902084
    nsv349350CNV Loss16902084
    nsv884425CNV Loss21882294
    nsv884418CNV Gain21882294

    Human Gene Mutation Database (HGMD): DDAH2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDAH2
    DNA2.0 Custom Variant and Variant Library Synthesis for DDAH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604744    OMIM disorders: --


    Find genes that share disorders with DDAH2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DDAH2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiovascular diseases 51.6 2 14550280 (1), 20219849 (1)
    atherosclerosis 41 2 17293168 (1), 18991678 (1), 17368960 (1)
    preeclampsia 35.6 11 18251679 (3), 19570459 (2), 15501905 (1), 16508323 (1)
    renal failure chronic 33.3 1 16932427 (1)
    diabetes mellitus 18.4 3 19775692 (2)
    necrosis 18.2 4 10377069 (1), 14604680 (1), 14750034 (1), 11168975 (1)
    hypercholesterolemia 11.5 2 10377069 (1), 17293168 (1)
    stroke 0 1 19250061 (1)
    hypertension pulmonary 0 2 12615801 (1), 15827267 (1)
    tumors 0 4 10377069 (1), 14604680 (1), 14750034 (1), 11168975 (1)

    Genetic Association Database (GAD): DDAH2
    Human Genome Epidemiology (HuGE) Navigator: DDAH2 (14 documents)

    Export disorders for DDAH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDAH2 gene, integrated from 10 sources (see all 149):
    (articles sorted by number of sources associating them with DDAH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. (PubMed id 10493931)1, 2, 3, 9 Leiper J.M.... Vallance P. (Biochem. J. 1999)
    2. Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. (PubMed id 10950934)1, 7, 9 Tran C.T....Leiper J.M. (Genomics 2000)
    3. Common genetic variation in DDAH2 is associated with intracerebral haemorrhage in a Chinese population: a multi-centre case-control study in China. (PubMed id 19250061)1, 4, 9 Bai Y....Hui R. (Clin. Sci. 2009)
    4. Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. (PubMed id 20209122)1, 4, 9 Abhary S....Craig J.E. (PLoS ONE 2010)
    5. Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension. (PubMed id 19666123)1, 4, 9 Maas R....Lieb W. (Pharmacol. Res. 2009)
    6. Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study. (PubMed id 17002794)1, 4, 9 O'Dwyer M.J....Ryan T. (Crit Care 2006)
    7. Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms. (PubMed id 20010544)1, 4, 9 Caplin B....Leiper J.M. (Kidney Int. 2010)
    8. Assessment of serum levels of asymmetric dimethylarginine, symmetric dimethylarginine and L-arginine in coronary artery disease. (PubMed id 20936901)1, 4 Gad M.Z....Elgabarty H.A. (Biomarkers 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. (PubMed id 19143821)1, 4 McKinnon E....James I. (amp 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23564 HGNC: 2716 AceView: CLIC1 Ensembl:ENSG00000213722 euGenes: HUgn23564
    ECgene: DDAH2 H-InvDB: DDAH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DDAH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DDAH2 gene:
    Search GeneIP for patents involving DDAH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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