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Aliases for DDAH2 Gene

Aliases for DDAH2 Gene

  • Dimethylarginine Dimethylaminohydrolase 2 2 3 4
  • Dimethylargininase-2 3 4
  • S-Phase Protein 3 4
  • EC 4 63
  • DDAHII 3 4
  • DDAH 3 4
  • NG30 3 4
  • G6a 3 4
  • N(G),N(G)-Dimethylarginine Dimethylaminohydrolase 2 3
  • Dimethylarginine Dimethylaminohydrolase II 3
  • Epididymis Secretory Protein Li 277 3
  • Protein G6a 4
  • HEL-S-277 3
  • DDAH-2 4

External Ids for DDAH2 Gene

Previous GeneCards Identifiers for DDAH2 Gene

  • GC06M031758
  • GC06M031465
  • GC06M031799
  • GC06M031803
  • GC06M031694
  • GC06M031481

Summaries for DDAH2 Gene

Entrez Gene Summary for DDAH2 Gene

  • This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for DDAH2 Gene

DDAH2 (Dimethylarginine Dimethylaminohydrolase 2) is a Protein Coding gene. GO annotations related to this gene include amino acid binding and dimethylargininase activity. An important paralog of this gene is DDAH1.

UniProtKB/Swiss-Prot for DDAH2 Gene

  • Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDAH2 Gene

Genomics for DDAH2 Gene

Regulatory Elements for DDAH2 Gene

Transcription factor binding sites by QIAGEN in the DDAH2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDAH2 Gene

31,727,038 bp from pter
31,730,617 bp from pter
3,580 bases
Minus strand

Genomic View for DDAH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDAH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for DDAH2 Gene

  • Protein details for DDAH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
    Protein Accession:
    Secondary Accessions:
    • A2BEZ7

    Protein attributes for DDAH2 Gene

    285 amino acids
    Molecular mass:
    29644 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DDAH2 Gene

Proteomics data for DDAH2 Gene at MOPED

Post-translational modifications for DDAH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for DDAH2 Gene

Protein Domains for DDAH2 Gene


Suggested Antigen Peptide Sequences for DDAH2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DDAH family.
  • Belongs to the DDAH family.
genes like me logo Genes that share domains with DDAH2: view

Function for DDAH2 Gene

Molecular function for DDAH2 Gene

GENATLAS Biochemistry:
N-omega,N-omega dimethylarginine dimethylaminohydrolase,endogenous inhibitor of nitric oxide synthesis,encoded by G6A,member of MHC3
UniProtKB/Swiss-Prot CatalyticActivity:
N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.
UniProtKB/Swiss-Prot Function:
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

Enzyme Numbers (IUBMB) for DDAH2 Gene

Gene Ontology (GO) - Molecular Function for DDAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 10493931
GO:0005515 protein binding IPI 16189514
GO:0016403 dimethylargininase activity IDA 10493931
GO:0016597 amino acid binding IEA --
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines --
genes like me logo Genes that share ontologies with DDAH2: view

Phenotypes for DDAH2 Gene

MGI mutant phenotypes for DDAH2:
inferred from 1 alleles
GenomeRNAi human phenotypes for DDAH2:
genes like me logo Genes that share phenotypes with DDAH2: view

Animal Models for DDAH2 Gene

MGI Knock Outs for DDAH2:

Animal Model Products

miRNA for DDAH2 Gene

miRTarBase miRNAs that target DDAH2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDAH2

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DDAH2 Gene

Localization for DDAH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDAH2 Gene

Cytoplasm. Mitochondrion. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes.

Subcellular locations from

Jensen Localization Image for DDAH2 Gene COMPARTMENTS Subcellular localization image for DDAH2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DDAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005813 centrosome IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DDAH2: view

Pathways for DDAH2 Gene

SuperPathways for DDAH2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DDAH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000052 citrulline metabolic process IDA 10493931
GO:0006525 arginine metabolic process --
GO:0006527 arginine catabolic process TAS 10493931
GO:0006809 nitric oxide biosynthetic process TAS 10493931
GO:0007263 nitric oxide mediated signal transduction TAS 10493931
genes like me logo Genes that share ontologies with DDAH2: view

No data available for Pathways by source for DDAH2 Gene

Drugs for DDAH2 Gene

(1) Drugbank Compounds for DDAH2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (S)-2-Amino-5-ureidopentanoic acid
372-75-8 9750 Target approved, nutraceutical

(4) HMDB Compounds for DDAH2 Gene

Compound Synonyms Cas Number PubMed IDs
Asymmetric dimethylarginine
  • 2-Amino-5-(amino-dimethylamino-methylidene)amino-pentanoate
  • (2S)-2-amino-5-(carbamoylamino)pentanoate
  • Dimethylamine
  • Dihydrogen oxide

(26) Novoseek inferred chemical compound relationships for DDAH2 Gene

Compound -log(P) Hits PubMed IDs
adma 97.5 202
demethylbellidifolin 85.3 1
n(g),n(g)-dimethylarginine 84.8 3
dimethylamine 82.8 7
citrulline 80.8 17
genes like me logo Genes that share compounds with DDAH2: view

Transcripts for DDAH2 Gene

Unigene Clusters for DDAH2 Gene

Dimethylarginine dimethylaminohydrolase 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDAH2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDAH2 Gene

No ASD Table

Relevant External Links for DDAH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDAH2 Gene

mRNA expression in normal human tissues for DDAH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DDAH2 Gene

This gene is overexpressed in Fetal Brain (6.8) and Nasopharynx (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DDAH2 Gene

SOURCE GeneReport for Unigene cluster for DDAH2 Gene Hs.247362

mRNA Expression by UniProt/SwissProt for DDAH2 Gene

Tissue specificity: Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain.
genes like me logo Genes that share expressions with DDAH2: view

Expression partners for DDAH2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DDAH2 Gene

Orthologs for DDAH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDAH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDAH2 35
  • 89.82 (n)
  • 96.49 (a)
DDAH2 36
  • 96 (a)
(Canis familiaris)
Mammalia DDAH2 35
  • 91.23 (n)
  • 98.25 (a)
DDAH2 36
  • 97 (a)
(Mus musculus)
Mammalia Ddah2 35
  • 89.44 (n)
  • 97.54 (a)
Ddah2 16
Ddah2 36
  • 97 (a)
(Pan troglodytes)
Mammalia DDAH2 35
  • 99.65 (n)
  • 99.65 (a)
DDAH2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ddah2 35
  • 88.15 (n)
  • 97.18 (a)
(Monodelphis domestica)
Mammalia DDAH2 36
  • 90 (a)
(Anolis carolinensis)
Reptilia DDAH2 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ddah2 35
  • 60.78 (n)
  • 59.4 (a)
(Danio rerio)
Actinopterygii ddah2 35
  • 55.85 (n)
  • 51.12 (a)
ddah2 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1764 37
  • 33 (a)
CG1764 36
  • 33 (a)
Species with no ortholog for DDAH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDAH2 Gene

Gene Tree for DDAH2 (if available)
Gene Tree for DDAH2 (if available)

Paralogs for DDAH2 Gene

Paralogs for DDAH2 Gene

(1) SIMAP similar genes for DDAH2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DDAH2: view

Variants for DDAH2 Gene

Sequence variations from dbSNP and Humsavar for DDAH2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs453560 -- 31,729,899(-) CGGGT(C/G)CTGGA upstream-variant-2KB, intron-variant
rs707916 -- 31,729,781(-) GGTCG(C/T)GCTAG utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs805305 -- 31,729,610(-) GGGTC(C/G)CGGGC utr-variant-5-prime, intron-variant, upstream-variant-2KB
rs3116672 -- 31,726,548(-) GGGTG(C/T)GCCCT downstream-variant-500B
rs3763297 -- 31,729,889(+) TACTC(C/G)CGGCT upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDAH2 Gene

Variant ID Type Subtype PubMed ID
nsv884418 CNV Gain 21882294
nsv884425 CNV Loss 21882294
nsv349349 CNV Loss 16902084
nsv349350 CNV Loss 16902084

Relevant External Links for DDAH2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDAH2 Gene

Disorders for DDAH2 Gene

(11) Novoseek inferred disease relationships for DDAH2 Gene

Disease -log(P) Hits PubMed IDs
cardiovascular diseases 51.6 2
atherosclerosis 41 3
preeclampsia 35.6 7
renal failure chronic 33.3 1
diabetes mellitus 18.4 2

Relevant External Links for DDAH2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DDAH2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for DDAH2 Gene

Publications for DDAH2 Gene

  1. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. (PMID: 10493931) Leiper J.M. … Vallance P. (Biochem. J. 1999) 2 3 4 23
  2. Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. (PMID: 10950934) Tran C.T. … Leiper J.M. (Genomics 2000) 3 23 25 26
  3. Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study. (PMID: 17002794) O'Dwyer M.J. … Ryan T. (Crit Care 2006) 3 23 48
  4. Common genetic variation in DDAH2 is associated with intracerebral haemorrhage in a Chinese population: a multi-centre case-control study in China. (PMID: 19250061) Bai Y. … Hui R. (Clin. Sci. 2009) 3 23 48
  5. Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension. (PMID: 19666123) Maas R. … Lieb W. (Pharmacol. Res. 2009) 3 23 48

Products for DDAH2 Gene

Sources for DDAH2 Gene

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