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Aliases for DDAH1 Gene

Aliases for DDAH1 Gene

  • Dimethylarginine Dimethylaminohydrolase 1 2 3 4 5
  • Dimethylargininase-1 3 4
  • EC 3.5.3.18 4 63
  • DDAH-1 3 4
  • DDAHI 3 4
  • DDAH 3 4
  • NG, NG-Dimethylarginine Dimethylaminohydrolase 3
  • Epididymis Secretory Protein Li 16 3
  • HEL-S-16 3

External Ids for DDAH1 Gene

Previous GeneCards Identifiers for DDAH1 Gene

  • GC01M086186
  • GC01M084928
  • GC01M085072
  • GC01M085206
  • GC01M085496
  • GC01M085785
  • GC01M083894

Summaries for DDAH1 Gene

Entrez Gene Summary for DDAH1 Gene

  • This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDAH1 Gene

DDAH1 (Dimethylarginine Dimethylaminohydrolase 1) is a Protein Coding gene. Among its related pathways are eNOS activation and regulation and Metabolism. GO annotations related to this gene include amino acid binding and dimethylargininase activity. An important paralog of this gene is DDAH2.

UniProtKB/Swiss-Prot for DDAH1 Gene

  • Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

Tocris Summary for DDAH1 Gene

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDAH1 Gene

Genomics for DDAH1 Gene

Regulatory Elements for DDAH1 Gene

Enhancers for DDAH1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDAH1 on UCSC Golden Path with GeneCards custom track

Promoters for DDAH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDAH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDAH1 Gene

Chromosome:
1
Start:
85,318,481 bp from pter
End:
85,578,363 bp from pter
Size:
259,883 bases
Orientation:
Minus strand

Genomic View for DDAH1 Gene

Genes around DDAH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDAH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDAH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDAH1 Gene

Proteins for DDAH1 Gene

  • Protein details for DDAH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94760-DDAH1_HUMAN
    Recommended name:
    N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
    Protein Accession:
    O94760
    Secondary Accessions:
    • Q5HYC8
    • Q86XK5

    Protein attributes for DDAH1 Gene

    Size:
    285 amino acids
    Molecular mass:
    31122 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DDAH1 Gene

    Alternative splice isoforms for DDAH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDAH1 Gene

Proteomics data for DDAH1 Gene at MOPED

Post-translational modifications for DDAH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDAH1 Gene

Antibody Products

  • R&D Systems Antibodies for DDAH1 (Dimethylarginine Dimethylaminohydrolase 1/DDAH1)

Domains & Families for DDAH1 Gene

Protein Domains for DDAH1 Gene

Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O94760

UniProtKB/Swiss-Prot:

DDAH1_HUMAN :
  • Belongs to the DDAH family.
Family:
  • Belongs to the DDAH family.
genes like me logo Genes that share domains with DDAH1: view

Function for DDAH1 Gene

Molecular function for DDAH1 Gene

GENATLAS Biochemistry:
N-omega,N-omega dimethylarginine dimethylaminohydrolase 1
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=69 uM for asymmetric dimethylarginine (ADMA) {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; KM=54 uM for monomethyl-L-arginine (MMA) {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; KM=3.1 uM for S-methyl-L-thiocitrulline {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; Vmax=356 nmol/min/mg enzyme with ADMA {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; Vmax=154 nmol/min/mg enzyme with NMA {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506};
UniProtKB/Swiss-Prot CatalyticActivity:
N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by zinc ions (By similarity). Enzyme purified in the absence of 1,10-phenanthroline contains on average 0.4 zinc atoms per subunit. Inhibited by 4-hydroxy-nonenal through the formation of a covalent adduct with His-173. Competitively inhibited by N(5)-iminopropyl-ornithine.
UniProtKB/Swiss-Prot Function:
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

Enzyme Numbers (IUBMB) for DDAH1 Gene

genes like me logo Genes that share phenotypes with DDAH1: view

Animal Models for DDAH1 Gene

MGI Knock Outs for DDAH1:

Animal Model Products

  • Taconic Biosciences Mouse Models for DDAH1

miRNA for DDAH1 Gene

miRTarBase miRNAs that target DDAH1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DDAH1 Gene

Localization for DDAH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDAH1 Gene COMPARTMENTS Subcellular localization image for DDAH1 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3
nucleus 3
plasma membrane 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDAH1 Gene

Pathways & Interactions for DDAH1 Gene

genes like me logo Genes that share pathways with DDAH1: view

Pathways by source for DDAH1 Gene

Interacting Proteins for DDAH1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284031%0d%0a9606.ENSP00000217958%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000311505%0d%0a9606.ENSP00000349467%0d%0a
Selected Interacting proteins: ENSP00000284031 O94760-DDAH1_HUMAN for DDAH1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DDAH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000052 citrulline metabolic process IDA 19663506
GO:0003073 regulation of systemic arterial blood pressure ISS --
GO:0008152 metabolic process IEA --
GO:0046209 nitric oxide metabolic process TAS --
GO:0050999 regulation of nitric-oxide synthase activity TAS --
genes like me logo Genes that share ontologies with DDAH1: view

No data available for SIGNOR curated interactions for DDAH1 Gene

Drugs & Compounds for DDAH1 Gene

(5) Drugs for DDAH1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Citrulline Approved Nutra Full agonist, Agonist, Target 0
N,N-dimethylarginine Experimental Pharma 17

(6) Additional Compounds for DDAH1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dimethylamine
  • Dimethylamine
  • Dimethylamine anhydrous
  • Dimethylamine anhydrous (dot)
  • Dimethylamine aqueous solution
  • Dimethylamine hydrobromide
124-40-3
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DDAH1: view

Transcripts for DDAH1 Gene

Unigene Clusters for DDAH1 Gene

Dimethylarginine dimethylaminohydrolase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDAH1 Gene

No ASD Table

Relevant External Links for DDAH1 Gene

GeneLoc Exon Structure for
DDAH1
ECgene alternative splicing isoforms for
DDAH1

Expression for DDAH1 Gene

mRNA expression in normal human tissues for DDAH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DDAH1 Gene

This gene is overexpressed in Retina (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDAH1 Gene



SOURCE GeneReport for Unigene cluster for DDAH1 Gene Hs.713411

mRNA Expression by UniProt/SwissProt for DDAH1 Gene

O94760-DDAH1_HUMAN
Tissue specificity: Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle.
genes like me logo Genes that share expression patterns with DDAH1: view

Protein tissue co-expression partners for DDAH1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for DDAH1 Gene

Orthologs for DDAH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDAH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DDAH1 35
  • 91.46 (n)
  • 94.04 (a)
DDAH1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDAH1 35
  • 92.05 (n)
  • 94.04 (a)
DDAH1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddah1 35
  • 89.24 (n)
  • 93.68 (a)
Ddah1 16
Ddah1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DDAH1 35
  • 99.77 (n)
  • 99.65 (a)
DDAH1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddah1 35
  • 89.12 (n)
  • 93.33 (a)
oppossum
(Monodelphis domestica)
Mammalia DDAH1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDAH1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDAH1 35
  • 81.85 (n)
  • 87.19 (a)
DDAH1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDAH1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddah1 35
  • 71.99 (n)
  • 78.72 (a)
African clawed frog
(Xenopus laevis)
Amphibia ddah1-prov 35
zebrafish
(Danio rerio)
Actinopterygii zgc:85829 35
  • 67.94 (n)
  • 72.9 (a)
DDAH1 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1764 37
  • 38 (a)
CG1764 35
  • 49.61 (n)
  • 41.34 (a)
CG1764 36
  • 38 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001644 35
  • 48.51 (n)
  • 44.75 (a)
Species with no ortholog for DDAH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDAH1 Gene

ENSEMBL:
Gene Tree for DDAH1 (if available)
TreeFam:
Gene Tree for DDAH1 (if available)

Paralogs for DDAH1 Gene

Paralogs for DDAH1 Gene

(1) SIMAP similar genes for DDAH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DDAH1: view

Variants for DDAH1 Gene

Sequence variations from dbSNP and Humsavar for DDAH1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2613 -- 85,455,982(+) AAACT(C/G)CAATT intron-variant
rs2935 -- 85,451,880(+) AAGTG(A/G)TATGC intron-variant
rs3196 -- 85,318,632(+) AACCA(A/C/T)ACATT utr-variant-3-prime
rs9388 -- 85,318,585(+) CTAAA(G/T)GGCCG utr-variant-3-prime
rs18582 -- 85,329,136(+) AAGCA(A/G)AAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDAH1 Gene

Variant ID Type Subtype PubMed ID
esv34165 CNV Loss 18971310
nsv830459 CNV Loss 17160897
nsv830470 CNV Loss 17160897
nsv1766 CNV Insertion 18451855
esv2714296 CNV Deletion 23290073
esv2663134 CNV Deletion 23128226
nsv441699 CNV CNV 18776908
nsv821007 CNV Duplication 20802225
nsv823398 CNV Loss 20364138
esv21828 CNV Gain 19812545
esv2647869 CNV Gain 19546169
nsv436030 CNV Insertion 17901297
esv2440186 CNV Deletion 19546169

Variation tolerance for DDAH1 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.85; 34.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDAH1 Gene

Human Gene Mutation Database (HGMD)
DDAH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDAH1 Gene

Disorders for DDAH1 Gene

Relevant External Links for DDAH1

Genetic Association Database (GAD)
DDAH1
Human Genome Epidemiology (HuGE) Navigator
DDAH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDAH1

No disorders were found for DDAH1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDAH1 Gene

Publications for DDAH1 Gene

  1. Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. (PMID: 10950934) Tran C.T. … Leiper J.M. (Genomics 2000) 3 23 25 26
  2. Purification, cDNA cloning and expression of human NG,NG- dimethylarginine dimethylaminohydrolase. (PMID: 9874257) Kimoto M. … Tsuji H. (Eur. J. Biochem. 1998) 2 3 4 67
  3. Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia. (PMID: 12615801) Arrigoni F.I. … Leiper J.M. (Circulation 2003) 23 25 26
  4. Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms. (PMID: 20010544) Caplin B. … Leiper J.M. (Kidney Int. 2010) 3 23
  5. A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease. (PMID: 20167924) Ding H. … Wang D.W. (Circ. Res. 2010) 3 23

Products for DDAH1 Gene

Sources for DDAH1 Gene

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