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Aliases for DDAH1 Gene

Aliases for DDAH1 Gene

  • Dimethylarginine Dimethylaminohydrolase 1 2 3 4
  • Dimethylargininase-1 3 4
  • EC 3.5.3.18 4 64
  • DDAH-1 3 4
  • DDAHI 3 4
  • DDAH 3 4
  • N(G),N(G)-Dimethylarginine Dimethylaminohydrolase 1 3
  • NG, NG-Dimethylarginine Dimethylaminohydrolase 3
  • Epididymis Secretory Protein Li 16 3
  • HEL-S-16 3

External Ids for DDAH1 Gene

Summaries for DDAH1 Gene

Entrez Gene Summary for DDAH1 Gene

  • This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for DDAH1 Gene

DDAH1 (Dimethylarginine Dimethylaminohydrolase 1) is a Protein Coding gene. GO annotations related to this gene include amino acid binding and dimethylargininase activity. An important paralog of this gene is DDAH2.

UniProtKB/Swiss-Prot for DDAH1 Gene

  • Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDAH1 Gene

Genomics for DDAH1 Gene

Genomic Location for DDAH1 Gene

Start:
85,318,481 bp from pter
End:
85,578,363 bp from pter
Size:
259,883 bases
Orientation:
Minus strand

Genomic View for DDAH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDAH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDAH1 Gene

Regulatory Elements for DDAH1 Gene

Proteins for DDAH1 Gene

  • Protein details for DDAH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94760-DDAH1_HUMAN
    Recommended name:
    N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
    Protein Accession:
    O94760
    Secondary Accessions:
    • Q5HYC8
    • Q86XK5

    Protein attributes for DDAH1 Gene

    Size:
    285 amino acids
    Molecular mass:
    31122 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DDAH1 Gene

    Alternative splice isoforms for DDAH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DDAH1 Gene

Proteomics data for DDAH1 Gene at MOPED

Post-translational modifications for DDAH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDAH1 Gene

Domains for DDAH1 Gene

Protein Domains for DDAH1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

DDAH1_HUMAN
Family:
  • Belongs to the DDAH family.:
    • O94760
genes like me logo Genes that share domains with DDAH1: view

Function for DDAH1 Gene

Molecular function for DDAH1 Gene

GENATLAS Biochemistry: N-omega,N-omega dimethylarginine dimethylaminohydrolase 1
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=69 uM for asymmetric dimethylarginine (ADMA) {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; KM=54 uM for monomethyl-L-arginine (MMA) {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; KM=3.1 uM for S-methyl-L-thiocitrulline {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; Vmax=356 nmol/min/mg enzyme with ADMA {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; Vmax=154 nmol/min/mg enzyme with NMA {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506}; pH dependence: Optimum pH is 8.5. {ECO:0000269 PubMed:18171027, ECO:0000269 PubMed:19663506};
UniProtKB/Swiss-Prot CatalyticActivity: N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by zinc ions (By similarity). Enzyme purified in the absence of 1,10-phenanthroline contains on average 0.4 zinc atoms per subunit. Inhibited by 4-hydroxy-nonenal through the formation of a covalent adduct with His-173. Competitively inhibited by N(5)-iminopropyl-ornithine.
UniProtKB/Swiss-Prot Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation

Enzyme Numbers (IUBMB) for DDAH1 Gene

Gene Ontology (GO) - Molecular Function for DDAH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 9874257
GO:0016403 dimethylargininase activity IDA 19663506
GO:0016597 amino acid binding IEA --
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DDAH1: view
genes like me logo Genes that share phenotypes with DDAH1: view

Animal Models for DDAH1 Gene

MGI Knock Outs for DDAH1:

No data available for Transcription Factor Targeting and HOMER Transcription for DDAH1 Gene

Localization for DDAH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DDAH1 Gene COMPARTMENTS Subcellular localization image for DDAH1 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DDAH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DDAH1: view

Pathways for DDAH1 Gene

SuperPathways for DDAH1 Gene

No Data Available

Interacting Proteins for DDAH1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000284031%0d%0a9606.ENSP00000217958%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000311505%0d%0a9606.ENSP00000349467%0d%0a
Selected Interacting proteins: ENSP00000284031 O94760-DDAH1_HUMAN for DDAH1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DDAH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000052 citrulline metabolic process IDA 19663506
GO:0003073 regulation of systemic arterial blood pressure ISS --
GO:0006525 arginine metabolic process --
GO:0006527 arginine catabolic process TAS 9874257
GO:0007263 nitric oxide mediated signal transduction TAS 9874257
genes like me logo Genes that share ontologies with DDAH1: view

No data available for Pathways by source for DDAH1 Gene

Compounds for DDAH1 Gene

(1) HMDB Compounds for DDAH1 Gene

Compound Synonyms Cas Number PubMed IDs
Dimethylamine
  • Dimethylamine
124-40-3

(1) Drugbank Compounds for DDAH1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Citrulline
  • 2-Amino-5-uredovaleric acid
372-75-8 target

(9) Novoseek inferred chemical compound relationships for DDAH1 Gene

Compound -log(P) Hits PubMed IDs
adma 95.1 63
n(g),n(g)-dimethylarginine 87.9 3
dimethylamine 83.5 6
nitric oxide 71.2 25
citrulline 68.4 6
genes like me logo Genes that share compounds with DDAH1: view

Transcripts for DDAH1 Gene

Unigene Clusters for DDAH1 Gene

Dimethylarginine dimethylaminohydrolase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDAH1 Gene

No ASD Table

Relevant External Links for DDAH1 Gene

GeneLoc Exon Structure for
DDAH1
ECgene alternative splicing isoforms for
DDAH1

Expression for DDAH1 Gene

mRNA expression in normal human tissues for DDAH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDAH1 Gene

SOURCE GeneReport for Unigene cluster for DDAH1 Gene Hs.713411

mRNA Expression by UniProt/SwissProt for DDAH1 Gene

O94760-DDAH1_HUMAN
Tissue specificity: Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle.
genes like me logo Genes that share expressions with DDAH1: view

Orthologs for DDAH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDAH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDAH1 36
  • 99.77 (n)
  • 99.65 (a)
DDAH1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDAH1 36
  • 91.46 (n)
  • 94.04 (a)
DDAH1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DDAH1 36
  • 92.05 (n)
  • 94.04 (a)
DDAH1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddah1 36
  • 89.24 (n)
  • 93.68 (a)
Ddah1 16
Ddah1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDAH1 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DDAH1 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ddah1 36
  • 89.12 (n)
  • 93.33 (a)
chicken
(Gallus gallus)
Aves DDAH1 36
  • 81.85 (n)
  • 87.19 (a)
DDAH1 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DDAH1 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ddah1-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ddah1 36
  • 71.99 (n)
  • 78.72 (a)
zebrafish
(Danio rerio)
Actinopterygii DDAH1 37
  • 77 (a)
OneToOne
zgc:85829 36
  • 67.94 (n)
  • 72.9 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001644 36
  • 48.51 (n)
  • 44.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1764 36
  • 49.61 (n)
  • 41.34 (a)
CG1764 37
  • 38 (a)
OneToMany
CG1764 38
  • 38 (a)
Species with no ortholog for DDAH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDAH1 Gene

ENSEMBL:
Gene Tree for DDAH1 (if available)
TreeFam:
Gene Tree for DDAH1 (if available)

Paralogs for DDAH1 Gene

Paralogs for DDAH1 Gene

Selected SIMAP similar genes for DDAH1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DDAH1: view

Variants for DDAH1 Gene

Sequence variations from dbSNP and Humsavar for DDAH1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2613 -- 85,455,982(+) AAACT(C/G)CAATT intron-variant
rs2935 -- 85,451,880(+) AAGTG(A/G)TATGC intron-variant
rs3196 -- 85,318,632(+) AACCA(A/C/T)ACATT utr-variant-3-prime
rs9388 -- 85,318,585(+) CTAAA(G/T)GGCCG utr-variant-3-prime
rs18582 -- 85,329,136(+) AAGCA(A/G)AAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDAH1 Gene

Variant ID Type Subtype PubMed ID
esv34165 CNV Loss 18971310
nsv830459 CNV Loss 17160897
nsv830470 CNV Loss 17160897
nsv1766 CNV Insertion 18451855
esv2714296 CNV Deletion 23290073
esv2663134 CNV Deletion 23128226
nsv441699 CNV CNV 18776908
nsv821007 CNV Duplication 20802225
nsv823398 CNV Loss 20364138
esv21828 CNV Gain 19812545
esv2647869 CNV Gain 19546169
nsv436030 CNV Insertion 17901297
esv2440186 CNV Deletion 19546169

Relevant External Links for DDAH1 Gene

HapMap Linkage Disequilibrium report
DDAH1
Human Gene Mutation Database (HGMD)
DDAH1

Disorders for DDAH1 Gene

(5) Novoseek inferred disease relationships for DDAH1 Gene

Disease -log(P) Hits PubMed IDs
cardiovascular diseases 49 2
atherosclerosis 34.9 2
glioma 6.53 5
tumors 4.37 4
shock 0 2

Relevant External Links for DDAH1

Genetic Association Database (GAD)
DDAH1
Human Genome Epidemiology (HuGE) Navigator
DDAH1
genes like me logo Genes that share disorders with DDAH1: view

No data available for UniProtKB/Swiss-Prot for DDAH1 Gene

Publications for DDAH1 Gene

  1. Haplotypic association of DDAH1 with susceptibility to pre-eclampsia. (PMID: 15501905) Akbar F. … Salonen J.T. (Mol. Hum. Reprod. 2005) 3 23 49
  2. Disruption of methylarginine metabolism impairs vascular homeostasis. (PMID: 17273169) Leiper J. … Vallance P. (Nat. Med. 2007) 3 4 23
  3. Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide. (PMID: 19663506) Wang Y. … Fast W. (Biochemistry 2009) 3 4 23
  4. A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease. (PMID: 20167924) Ding H. … Wang D.W. (Circ. Res. 2010) 3 23 49
  5. Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. (PMID: 20209122) Abhary S. … Craig J.E. (PLoS ONE 2010) 3 23 49

Products for DDAH1 Gene

Sources for DDAH1 Gene

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