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DDAH1 Gene

protein-coding   GIFtS: 60
GCID: GC01M085785

Dimethylarginine Dimethylaminohydrolase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dimethylarginine Dimethylaminohydrolase 11 2 3     dimethylargininase-12
DDAH2 3     Epididymis Secretory Protein Li 162
DDAH-12 3     N(G),N(G)-Dimethylarginine Dimethylaminohydrolase 12
DDAHI2 3     NG, NG-Dimethylarginine Dimethylaminohydrolase2
EC 3.5.3.183 8     Dimethylargininase-13
HEL-S-162     

External Ids:    HGNC: 27151   Entrez Gene: 235762   Ensembl: ENSG000001539047   OMIM: 6047435   UniProtKB: O947603   

Export aliases for DDAH1 gene to outside databases

Previous GC identifers: GC01M086186 GC01M084928 GC01M085072 GC01M085206 GC01M085496 GC01M083894


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DDAH1 Gene:
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a
role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit
nitric oxide synthase activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for DDAH1 Gene:
DDAH1 (dimethylarginine dimethylaminohydrolase 1) is a protein-coding gene. GO annotations related to this gene include dimethylargininase activity and amino acid binding. An important paralog of this gene is DDAH2.

UniProtKB/Swiss-Prot: DDAH1_HUMAN, O94760
Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as
inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DDAH1 gene promoter:
         E2F-4   E2F-3a   SRF   E2F-5   E2F-1   E2F   SRF (504 AA)   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDAH1 promoter sequence
   Search Chromatin IP Primers for DDAH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDAH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22

DDAH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDAH1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M085785:  view genomic region     (about GC identifiers)

Start:
85,784,164 bp from pter      End:
86,044,046 bp from pter
Size:
259,883 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DDAH1_HUMAN, O94760 (See protein sequence)
Recommended Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1  
Size: 285 amino acids; 31122 Da
Subunit: Monomer
6 PDB 3D structures from and Proteopedia for DDAH1:
2JAI (3D)        2JAJ (3D)        3I2E (3D)        3I4A (3D)        3P8E (3D)        3P8P (3D)    
Secondary accessions: Q5HYC8 Q86XK5
Alternative splicing: 2 isoforms:  O94760-1   O94760-2   

Explore the universe of human proteins at neXtProt for DDAH1: NX_O94760

Explore proteomics data for DDAH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DDAH1 (O94760) (see all 5)
     AVSTVPV  DENATLDG  AANCIYLNIP  DVLFTGREFFVGLSK 


    See DDAH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127917.1  NP_036269.1  

    ENSEMBL proteins: 
     ENSP00000439045   ENSP00000284031   ENSP00000438604   ENSP00000411189   ENSP00000438202  

    DDAH1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: NG,NG-Dimethylarginine dimethylaminohydrolase 1
    Dimethylarginine dimethylaminohydrolases

    1 InterPro protein domain:
     IPR003198 Amidino_trans

    Graphical View of Domain Structure for InterPro Entry O94760

    ProtoNet protein and cluster: O94760

    1 Blocks protein domain: IPB003198 Amidinotransferase

    UniProtKB/Swiss-Prot: DDAH1_HUMAN, O94760
    Similarity: Belongs to the DDAH family


    Find genes that share domains with DDAH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDAH1_HUMAN, O94760
    Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as
    inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation
    Catalytic activity: N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline
    Enzyme regulation: Inhibited by zinc ions (By similarity). Enzyme purified in the absence of 1,10-phenanthroline
    contains on average 0.4 zinc atoms per subunit. Inhibited by 4-hydroxy-nonenal through the formation of a
    covalent adduct with His-173. Competitively inhibited by N(5)-iminopropyl-ornithine
    Biophysicochemical properties: Kinetic parameters: KM=69 uM for asymmetric dimethylarginine (ADMA); KM=54 uM for
    monomethyl-L-arginine (MMA); KM=3.1 uM for S-methyl-L-thiocitrulline; Vmax=356 nmol/min/mg enzyme with ADMA;
    Vmax=154 nmol/min/mg enzyme with NMA; pH dependence: Optimum pH is 8.5;

         Genatlas biochemistry entry for DDAH1:
    N-omega,N-omega dimethylarginine dimethylaminohydrolase 1

         Enzyme Number (IUBMB): EC 3.5.3.181 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS9874257
    GO:0016403dimethylargininase activity IDA19663506
    GO:0016597amino acid binding IEA--
    GO:0016813hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines ----
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with DDAH1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDAH1:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ddah1):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle 

    Find genes that share phenotypes with DDAH1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DDAH1: Ddah1tm1Pval Ddah1tm1.1Yjch

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DDAH1
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    miRTarBase miRNAs that target DDAH1:
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    Block miRNA regulation of human, mouse, rat DDAH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DDAH1 (see all 38):
    hsa-miR-21* hsa-miR-3164 hsa-miR-330-5p hsa-miR-548k hsa-miR-513a-5p hsa-miR-128 hsa-miR-30d hsa-miR-219-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat DDAH1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with DDAH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DDAH1
    Interactions:

        GeneGlobe Interaction Network for DDAH1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for DDAH1 (O947603 ENSP000002840314) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    RPS6KA1Q154183I2D: score=2 
    DLG4P783523I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000052citrulline metabolic process IDA19663506
    GO:0003073regulation of systemic arterial blood pressure ISS--
    GO:0006525arginine metabolic process ----
    GO:0006527arginine catabolic process TAS9874257
    GO:0007263nitric oxide mediated signal transduction TAS9874257

    Find genes that share ontologies with DDAH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDAH1

    1 HMDB Compound for DDAH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    DimethylamineDimethylamine (see all 10)124-40-3--

    1 DrugBank Compound for DDAH1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--10950934 12615801 14766200

    9 Novoseek inferred chemical compound relationships for DDAH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adma 95.1 96 20209122 (6), 19331593 (4), 19820234 (4), 20219849 (4) (see all 33)
    n(g),n(g)-dimethylarginine 87.9 5 7608105 (1), 15292099 (1), 15865451 (1)
    dimethylamine 83.5 6 17400039 (2), 19331593 (1), 15465797 (1), 17011246 (1) (see all 5)
    nitric oxide 71.2 34 20219849 (4), 16920729 (2), 19663506 (2), 15865451 (2) (see all 18)
    citrulline 68.4 6 19331593 (1), 19820234 (1), 17400039 (1), 12615801 (1) (see all 6)
    l-nmma 65.5 6 12941821 (1), 17273169 (1), 11811522 (1)
    arginine 60 10 15325021 (1), 20167924 (1), 18171027 (1), 19013076 (1) (see all 5)
    2,4-dichlorophenoxyacetic acid 55.8 2 14553822 (1)
    oxygen 0 3 15256062 (1), 18171027 (1)



    Find genes that share compounds with DDAH1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDAH1 gene (2 alternative transcripts): 
    NM_001134445.1  NM_012137.3  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535924(uc001dlc.3) ENST00000284031(uc001dlb.3) ENST00000483110(uc010osb.2 uc009wco.3)
    ENST00000488557 ENST00000498304 ENST00000467530 ENST00000472448 ENST00000467666
    ENST00000539042 ENST00000426972 ENST00000542148
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    hsa-miR-21* hsa-miR-3164 hsa-miR-330-5p hsa-miR-548k hsa-miR-513a-5p hsa-miR-128 hsa-miR-30d hsa-miR-219-5p
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    Selected AceView cDNA sequences (see all 249):

    BM985268 CB105401 AA729920 CA441647 AV728374 AI753284 AI127358 NM_012137 
    AA633809 AA433886 AA972450 BE221291 AI087223 BG152516 AA452502 AA433895 
    AA304527 AW661908 BM971417 BC033680 BU732812 AW196691 AI650308 AI150719 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDAH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATACCAATC
    DDAH1 Expression
    About this image


    DDAH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Dental pulp stem cells
    DDAH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDAH1 Protein Expression

    UniProtKB/Swiss-Prot: DDAH1_HUMAN, O94760
    Tissue specificity: Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDAH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DDAH1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ddah11 , 5 dimethylarginine dimethylaminohydrolase 11, 5 89.24(n)1
    93.68(a)1
      3 (70.63 cM)5
    692191  NM_026993.31  NP_081269.11 
     1457586755 
    chicken
    (Gallus gallus)
    Aves DDAH11 dimethylarginine dimethylaminohydrolase 1 81.85(n)
    87.19(a)
      378898  NM_204382.1  NP_989713.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDAH16
    dimethylarginine dimethylaminohydrolase 1
    79(a)
    1 ↔ 1
    GL343194.1(10322420-10402441)
    African clawed frog
    (Xenopus laevis)
    Amphibia ddah1-prov2 dimethylarginine dimethylaminohydrolase 1 77.98(n)    BC056074.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:858291 zgc:85829 67.94(n)
    72.9(a)
      406561  NM_213276.1  NP_998441.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG17641 , 3 dimethylargininase3
    CG17641
    38(a)3
    49.61(n)1
    41.34(a)1
      11E93
    322811  NM_132643.21  NP_572871.11 


    ENSEMBL Gene Tree for DDAH1 (if available)
    TreeFam Gene Tree for DDAH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDAH1 gene
    DDAH22  
    1 SIMAP similar gene for DDAH1 using alignment to 4 protein entries:     DDAH1_HUMAN (see all proteins):
    DDAH2

    Find genes that share paralogs with DDAH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDAH1 (see all 4880)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352796621,2
    C--84003660(+) AAAAA-/A/AAAA
            
    GTGGG
    2 -- int11NA 2
    rs576779541,2
    C--84095566(+) TTTTT-/T/TT  
            
    GAGAC
    1 -- int11NA 2
    rs1883621501,2
    --85783739(+) CATTTA/TAAAAA 2 -- ds50010--------
    rs121386211,2
    C,F,H--85783970(+) TTAAGT/CGCCTG 2 -- ds500119Minor allele frequency- C:0.12NS EA NA CSA WA 2344
    rs780978211,2
    C,F--85784101(+) GACAGC/AAAAGA 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1489133291,2
    --85784166(+) CTGTTC/GATCAC 2 -- ds50010--------
    rs1160898401,2
    C,F--85784200(+) ATTGTG/CATTGG 2 -- ut311Minor allele frequency- C:0.03WA 118
    rs1926484541,2
    --85784212(+) ATACAG/TGTAAG 2 -- ut310--------
    rs1845303621,2
    --85784219(+) TAAGAC/TTGAGA 2 -- ut310--------
    rs1435946391,2
    --85784314(+) TAACCA/GTACAT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DDAH1 (85784164 - 86034164 bp, first 250kb of DDAH1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DDAH1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714296CNV Deletion23290073
    esv2663134CNV Deletion23128226
    esv2440186CNV Deletion19546169
    nsv821007CNV Duplication20802225
    nsv1766CNV Insertion18451855
    nsv436030CNV Insertion17901297
    nsv830470CNV Loss17160897
    nsv830459CNV Loss17160897
    esv34165CNV Loss18971310
    nsv823398CNV Loss20364138

    Human Gene Mutation Database (HGMD): DDAH1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDAH1
    DNA2.0 Custom Variant and Variant Library Synthesis for DDAH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604743    OMIM disorders: --


    Find genes that share disorders with DDAH1           About GenesLikeMe

    5 Novoseek inferred disease relationships for DDAH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiovascular diseases 49 2 17881609 (1), 16444868 (1)
    atherosclerosis 34.9 2 19331593 (1), 17881609 (1)
    glioma 6.53 8 12941821 (3), 15256062 (2)
    tumors 4.37 8 15256062 (2), 12941821 (2)
    shock 0 2 17273169 (1), 15292099 (1)

    Genetic Association Database (GAD): DDAH1
    Human Genome Epidemiology (HuGE) Navigator: DDAH1 (13 documents)

    Export disorders for DDAH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDAH1 gene, integrated from 10 sources (see all 100):
    (articles sorted by number of sources associating them with DDAH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, cDNA cloning and expression of human NG,NG- dimethylarginine dimethylaminohydrolase. (PubMed id 9874257)1, 2, 3 Kimoto M.... Tsuji H. (Eur. J. Biochem. 1998)
    2. A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease. (PubMed id 20167924)1, 4, 9 Ding H....Wang D.W. (Circ. Res. 2010)
    3. Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. (PubMed id 20209122)1, 4, 9 Abhary S....Craig J.E. (PLoS ONE 2010)
    4. Haplotypic association of DDAH1 with susceptibility to pre-eclampsia. (PubMed id 15501905)1, 4, 9 Akbar F....Salonen J.T. (Mol. Hum. Reprod. 2005)
    5. Circulating methylarginine levels and the decline in renal function in patients with chronic kidney disease are modulated by DDAH1 polymorphisms. (PubMed id 20010544)1, 4, 9 Caplin B....Leiper J.M. (Kidney Int. 2010)
    6. Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. (PubMed id 10950934)1, 7, 9 Tran C.T....Leiper J.M. (Genomics 2000)
    7. Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide. (PubMed id 19663506)1, 2, 9 Wang Y.... Fast W. (Biochemistry 2009)
    8. Disruption of methylarginine metabolism impairs vascular homeostasis. (PubMed id 17273169)1, 2, 9 Leiper J....Vallance P. (Nat. Med. 2007)
    9. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23576 HGNC: 2715 AceView: DDAH1 Ensembl:ENSG00000153904 euGenes: HUgn23576
    ECgene: DDAH1 H-InvDB: DDAH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDAH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDAH1 gene:
    Search GeneIP for patents involving DDAH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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