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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DDAH1 Gene

protein-coding   GIFtS: 63
GCID: GC01M085785

dimethylarginine dimethylaminohydrolase 1
 Explore 20 diseases affiliated with
DDAH1 via
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our new
 Human Malady Compendium 
Biological research products
for DDAH1    

Aliases
for DDAH1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dimethylarginine Dimethylaminohydrolase 11 2 3     Dimethylargininase-13
DDAH1 2 3     N(G),N(G)-Dimethylarginine Dimethylaminohydrolase 12
DDAH-12 3     NG, NG-Dimethylarginine Dimethylaminohydrolase2
DDAHI2 3     Dimethylargininase-13
EC 3.5.3.183 8     

External Ids:    HGNC: 27151   Entrez Gene: 235762   Ensembl: ENSG000001539047   OMIM: 6047435   UniProtKB: O947603   

Export aliases for DDAH1 gene to outside databases

Previous GC identifers: GC01M086186 GC01M084928 GC01M085072 GC01M085206 GC01M085496 GC01M083894


Summaries
for DDAH1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DDAH1:
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in
nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide
synthase activity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DDAH1_HUMAN, O94760
Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors
of NOS. Has therefore a role in the regulation of nitric oxide generation




Genomic Views
for DDAH1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DDAH1 gene promoter:
         E2F-4   E2F-3a   SRF   E2F-5   E2F-1   E2F   SRF (504 AA)   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DDAH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DDAH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDAH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22   Ensembl cytogenetic band:  1p22.3   HGNC cytogenetic band: 1p22

DDAH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDAH1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M085785:  view genomic region     (about GC identifiers)

Start:
 85,784,168 bp from pter      End:
 86,044,046 bp from pter
Size:
 259,879 bases      Orientation:
 minus strand

Proteins
for DDAH1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DDAH1_HUMAN, O94760 (See protein sequence)
Recommended Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1  
Size: 285 amino acids; 31122 Da
Subunit: Monomer
6 PDB 3D structures from and Proteopedia for DDAH1:
2JAI (3D)        2JAJ (3D)        3I2E (3D)        3I4A (3D)        3P8E (3D)        3P8P (3D)    
Secondary accessions: Q5HYC8 Q86XK5
Alternative splicing: 2 isoforms:  O94760-1   O94760-2   

Explore the universe of human proteins at neXtProt for DDAH1: NX_O94760

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O94760

    • 4/5 DME Specific Peptides for DDAH1 (O94760) (see all 5)
     AVSTVPV  DENATLDG  AANCIYLNIP  DVLFTGREFFVGLSK 

    DDAH1 Protein expression data from MOPED and PaxDb:    About this image 
    DDAH1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001127917.1  NP_036269.1  

    ENSEMBL proteins: 
     ENSP00000284031   ENSP00000438604   ENSP00000411189   ENSP00000438202   ENSP00000439045  

    Human Recombinant Protein Products for DDAH1: 
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    Uscn Proteins for DDAH1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--

    DDAH1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DDAH1

    Protein Domains /
    Families
    for DDAH1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DDAH1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003198 Amidino_trans

    Graphical View of Domain Structure for InterPro Entry O94760

    ProtoNet protein and cluster: O94760

    1 Blocks protein family: IPB003198 Amidinotransferase

    UniProtKB/Swiss-Prot: DDAH1_HUMAN, O94760
    Similarity: Belongs to the DDAH family


    Function
    for DDAH1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDAH1_HUMAN, O94760
    Function: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors
    of NOS. Has therefore a role in the regulation of nitric oxide generation
    Catalytic activity: N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline
    Enzyme regulation: Inhibited by zinc ions (By similarity). Enzyme purified in the absence of 1,10-phenanthroline
    contains on average 0.4 zinc atoms per subunit. Inhibited by 4-hydroxy-nonenal through the formation of a covalent
    adduct with His-173. Competitively inhibited by N(5)-iminopropyl-ornithine
    Biophysicochemical properties: Kinetic parameters: KM=69 uM for asymmetric dimethylarginine (ADMA); KM=54 uM for
    monomethyl-L-arginine (MMA); KM=3.1 uM for S-methyl-L-thiocitrulline; Vmax=356 nmol/min/mg enzyme with ADMA; Vmax=154
    nmol/min/mg enzyme with NMA; pH dependence: Optimum pH is 8.5;

         Genatlas biochemistry entry for DDAH1:
    N-omega,N-omega dimethylarginine dimethylaminohydrolase 1

         Enzyme Number (IUBMB): EC 3.5.3.181 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity TAS9874257
    GO:0016403dimethylargininase activity IDA19663506
    GO:0016597amino acid binding IEA--
    GO:0016813hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines ----
    GO:0046872metal ion binding IEA--
         
    DDAH1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DDAH1:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ddah1):
     cardiovascular system  homeostasis/metabolism  mortality/aging  muscle 

    DDAH1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for DDAH1: Ddah1tm1Pval Ddah1tm1.1Yjch
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    hsa-miR-21* hsa-miR-3164 hsa-miR-330-5p hsa-miR-548k hsa-miR-513a-5p hsa-miR-128 hsa-miR-30d hsa-miR-219-5p
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDAH1


    Pathways & Interactions
    for DDAH1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DDAH1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/8 Interacting proteins for DDAH1 (O947603 ENSP000002840314) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583I2D: score=1 
    CALM3P621583I2D: score=1 
    RPS6KA1Q154183I2D: score=2 
    DLG4P783523I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000052citrulline metabolic process IDA19663506
    GO:0003073regulation of systemic arterial blood pressure ISS--
    GO:0006525arginine metabolic process ----
    GO:0006527arginine catabolic process TAS9874257
    GO:0007263nitric oxide mediated signal transduction TAS9874257

    DDAH1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DDAH1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DDAH1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DDAH1

    1 HMDB Compound for DDAH1    About this table
    CompoundSynonyms CAS #PubMed Ids
    DimethylamineDimethylamine (see all 10)124-40-3--

    1 DrugBank Compound for DDAH1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Citrulline2-Amino-5-uredovaleric acid (see all 8)372-75-8target--10950934 12615801 14766200

    9 Novoseek chemical compound relationships for DDAH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adma 95.1 96 20209122 (6), 19331593 (4), 19820234 (4), 20219849 (4) (see all 33)
    n(g),n(g)-dimethylarginine 87.9 5 7608105 (1), 15292099 (1), 15865451 (1)
    dimethylamine 83.5 6 17400039 (2), 19331593 (1), 15465797 (1), 17011246 (1) (see all 5)
    nitric oxide 71.2 34 20219849 (4), 16920729 (2), 19663506 (2), 15865451 (2) (see all 18)
    citrulline 68.4 6 19331593 (1), 19820234 (1), 17400039 (1), 12615801 (1) (see all 6)
    l-nmma 65.5 6 12941821 (1), 17273169 (1), 11811522 (1)
    arginine 60 10 15325021 (1), 20167924 (1), 18171027 (1), 19013076 (1) (see all 5)
    2,4-dichlorophenoxyacetic acid 55.8 2 14553822 (1)
    oxygen 0 3 15256062 (1), 18171027 (1)

    Search CenterWatch for drugs/clinical trials and news about DDAH1 

    Transcripts
    for DDAH1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DDAH1 gene (2 alternative transcripts): 
    NM_001134445.1  NM_012137.3  

    Unigene Cluster for DDAH1:

    Dimethylarginine dimethylaminohydrolase 1
    Hs.713411  [show with all ESTs]
    Unigene Representative Sequence: NM_001134445
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284031(uc001dlb.3) ENST00000483110(uc010osb.2 uc009wco.3)
    ENST00000474200 ENST00000488557 ENST00000498304 ENST00000467530 ENST00000472448
    ENST00000467666 ENST00000539042 ENST00000426972 ENST00000542148 ENST00000535924(uc001dlc.3)


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    hsa-miR-21* hsa-miR-3164 hsa-miR-330-5p hsa-miR-548k hsa-miR-513a-5p hsa-miR-128 hsa-miR-30d hsa-miR-219-5p
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    Additional cDNA sequence: 

    AK024917.1 AK024926.1 AK026093.1 AK055626.1 AK098405.1 AK294752.1 AK302531.1 AK304876.1 
    AK309225.1 AK312432.1 BC033680.1 BC036432.2 BC043235.2 BX648145.1 

    11 DOTS entries:

    DT.443074  DT.99932765  DT.100060510  DT.110088  DT.303572  DT.438141  DT.121403946  DT.121403874 
    DT.121403899  DT.40276748  DT.92410304 

    24/249 AceView cDNA sequences (see all 249):

    BM473823 BQ187861 AA235983 AI241946 AI084610 AW295895 BQ637130 F01543 
    AW298727 CA414398 AI022958 Z40676 AA454088 BX107654 BU679894 AI024638 
    AI281073 AV722412 AI885718 BM971417 CK823288 BC033680 BU732812 AW196691 

    GeneLoc Exon Structure


    Expression
    for DDAH1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DDAH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATACCAATC
    DDAH1 Expression
    About this image

    DDAH1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive ErythrocytesBlood
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    CyT49 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Dorsal forebrain-like neurons (Generation of midbra...)Brain
    Matrigel embedded cells (Derivation of cardio...)
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See DDAH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DDAH1

    SOURCE GeneReport for Unigene cluster: Hs.713411

    UniProtKB/Swiss-Prot: DDAH1_HUMAN, O94760
    Tissue specificity: Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle

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    In Situ
    Assay Products:     
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    Orthologs
    for DDAH1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DDAH1 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DDAH11 dimethylarginine dimethylaminohydrolase 1 81.85(n)
    87.19(a)    		   378898  NM_204382.1  NP_989713.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DDAH16
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343194.1(10322420-10402441)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ddah1-prov2 dimethylarginine dimethylaminohydrolase 1 77.98(n)    BC056074.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:858291 zgc:85829 67.94(n)
    72.9(a)    		   406561  NM_213276.1  NP_998441.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG17641 , 3 dimethylargininase3
    CG17641    		 38(a)3
    49.74(n)1
    41.67(a)1    		   11E93
    322811  NM_132643.21  NP_572871.11 


    ENSEMBL Gene Tree for DDAH1 (if available)
    TreeFam Gene Tree for DDAH1 (if available) 

    Paralogs
    for DDAH1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DDAH1 gene
    DDAH22  
    1 SIMAP similar gene for DDAH1 using alignment to 4 protein entries:     DDAH1_HUMAN (see all proteins):
    DDAH2

    DDAH1 for paralogs           About GeneDecksing



    Genomic Variants
    for DDAH1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4356 NCBI SNPs in DDAH1 are shown (see all 4356)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1883621501,2
    		--85783739(+) CATTTA/TAAAAA 2 -- ds50010--------
    rs121386211,2
    		C,F,H--85783970(+) TTAAGT/CGCCTG 2 -- ds500119Minor allele frequency- C:0.12NS EA NA CSA WA 2344
    rs780978211,2
    		--85784101(+) GACAGC/AAAAGA 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1489133291,2
    		--85784166(+) CTGTTC/GATCAC 2 -- ds50010--------
    rs1160898401,2
    		F--85784200(+) ATTGTG/CATTGG 2 -- ut311Minor allele frequency- C:0.03WA 118
    rs1926484541,2
    		--85784212(+) ATACAG/TGTAAG 2 -- ut310--------
    rs1845303621,2
    		--85784219(+) TAAGAC/TTGAGA 2 -- ut310--------
    rs1435946391,2
    		--85784314(+) TAACCA/GTACAT 2 -- ut310--------
    rs31961,2
    		C--85784315(+) AACCAA/C/TACATT 4 -- ut311MN 184
    rs1509911361,2
    		--85784564(+) TTTCTA/GTAGCA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DDAH1 (85784168 - 86034168 bp, first 250kb of DDAH1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for DDAH1
         6 CNVs: 64124 84350 38186 97430 47846 97429
    Human Gene Mutation Database (HGMD): DDAH1

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    Disorders / Diseases
    for DDAH1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DDAH1 for disorders           About GeneDecksing

    OMIM gene information: 604743    OMIM disorders: --

    20 diseases for DDAH1:    About MalaCards
    pre-eclampsia    idiopathic pulmonary fibrosis    pulmonary fibrosis    eclampsia
    pulmonary hypertension    hyperhomocysteinemia    fibrosis    kidney disease
    liver disease    thrombosis    homocysteine    hypertension
    alzheimer's disease    infertility    prostate cancer    cerebritis
    hypoxia    prostatitis    schizophrenia    hepatitis

    5 Novoseek disease relationships for DDAH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cardiovascular diseases 49 2 17881609 (1), 16444868 (1)
    atherosclerosis 34.9 2 19331593 (1), 17881609 (1)
    glioma 6.53 8 12941821 (3), 15256062 (2)
    tumors 4.37 8 15256062 (2), 12941821 (2)
    shock 0 2 17273169 (1), 15292099 (1)

    Genetic Association Database (GAD): DDAH1
    Human Genome Epidemiology (HuGE) Navigator: DDAH1 (13 documents)

    Export disorders for DDAH1 gene to outside databases

    Publications
    for DDAH1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DDAH1 gene, integrated from 9 sources (see all 92):
    (articles sorted by number of sources associating them with DDAH1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification, cDNA cloning and expression of human NG,NG- dimethylarginine dimethylaminohydrolase. (PubMed id 9874257)1, 2, 3 Kimoto M.... Tsuji H. (1998)
    2. Haplotypic association of DDAH1 with susceptibility to pre-eclampsia. (PubMed id 15501905)1, 4, 9 Akbar F....Salonen J.T. (2005)
    3. Chromosomal localization, gene structure, and expression pattern of DDAH1: comparison with DDAH2 and implications for evolutionary origins. (PubMed id 10950934)1, 7, 9 Tran C.T....Leiper J.M. (2000)
    4. Developing dual and specific inhibitors of dimethylar ginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted po lypharmacology to control nitric oxide. (PubMed id 19663506)1, 2, 9 Wang Y....Fast W. (2009)
    5. Disruption of methylarginine metabolism impairs vascular homeostasis. (PubMed id 17273169)1, 2, 9 Leiper J....Vallance P. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases. (PubMed id 10493931)1, 2 Leiper J.M.... Vallance P. (1999)
    8. A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary h eart disease. (PubMed id 20167924)1, 9 Ding H....Wang D.W. (2010)
    9. Sequence variation in DDAH1 and DDAH2 genes is strong ly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. (PubMed id 20209122)1, 9 Abhary S....Craig J.E. (2010)
    10. Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation. (PubMed id 18171027)2, 9 Forbes S.P....Cardounel A.J. (2008)

    External Searches for DDAH1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DDAH1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23576 HGNC: 2715 AceView: DDAH1 Ensembl:ENSG00000153904 euGenes: HUgn23576
    ECgene: DDAH1 H-InvDB: DDAH1

    Other Databases showing DDAH1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DDAH1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DDAH1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DDAH1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DDAH1 gene:
    Search GeneIP for patents involving DDAH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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