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DDA1 Gene

protein-coding   GIFtS: 45
GCID: GC19P017420

DET1 And DDB1 Associated 1

(Previous name: chromosome 19 open reading frame 58)
(Previous symbol: C19orf58)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
DET1 And DDB1 Associated 11 2     PCIA12 3
C19orf581 2 3     Chromosome 19 Open Reading Frame 581
Placenta Cross-Immune Reaction Antigen 12 3     Cross-Immune Reaction Antigen PCIA12
PCIA-12 3     DET1- And DDB1-Associated Protein 12

External Ids:    HGNC: 283601   Entrez Gene: 790162   Ensembl: ENSG000001303117   UniProtKB: Q9BW613   
ORGUL members:         

Export aliases for DDA1 gene to outside databases

Previous GC identifers: GC19P017284 GC19P016986


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DDA1 Gene:
DDA1 (DET1 and DDB1 associated 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: DDA1_HUMAN, Q9BW61
Function: May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component
of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the DDA1 gene promoter:
         C/EBPbeta   AML1a   AP-1   p53   MAZR   SRF (504 AA)   Olf-1   E47   GATA-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDDA1 promoter sequence
   Search Chromatin IP Primers for DDA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DDA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

DDA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DDA1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P017420:  view genomic region     (about GC identifiers)

Start:
17,420,327 bp from pter      End:
17,434,110 bp from pter
Size:
13,784 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DDA1_HUMAN, Q9BW61 (See protein sequence)
Recommended Name: DET1- and DDB1-associated protein 1  
Size: 102 amino acids; 11835 Da
Subunit: Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific
UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes

Explore the universe of human proteins at neXtProt for DDA1: NX_Q9BW61

Explore proteomics data for DDA1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys71
  • Modification sites at PhosphoSitePlus

  • See DDA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076955.1  
    ENSEMBL proteins: 
     ENSP00000473086   ENSP00000352928   ENSP00000472171  

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for DDA1 (7 products) 

     
    antibodies-online peptides for DDA1

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    antibodies-online antibodies for DDA1 (14 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018276 Ub_ligase_Det1/DDB1-complexing

    Graphical View of Domain Structure for InterPro Entry Q9BW61

    ProtoNet protein and cluster: Q9BW61

    UniProtKB/Swiss-Prot: DDA1_HUMAN, Q9BW61
    Similarity: Belongs to the DDA1 family


    Find genes that share domains with DDA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DDA1_HUMAN, Q9BW61
    Function: May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component
    of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins

    Phenotypes:
         2 GenomeRNAi human phenotypes for DDA1:

     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DDA1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DDA1 (see all 25):
    hsa-miR-3138 hsa-miR-1285 hsa-miR-421 hsa-miR-124 hsa-miR-342-5p hsa-miR-548x hsa-miR-205* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidDDA1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DDA1: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DDA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DDA1 (Q9BW613 ENSP000003529284) via UniProtKB, MINT, STRING, and/or I2D (see all 658)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    ENSG00000232804P081073I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DDA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DDA1 gene: 
    NM_024050.5  

    Unigene Cluster for DDA1:

    DET1 and DDB1 associated 1
    Hs.466154  [show with all ESTs]
    Unigene Representative Sequence: NM_024050
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593466 ENST00000359866(uc002ngd.3) ENST00000596582 ENST00000596925
    ENST00000594501
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DDA1 (see all 25):
    hsa-miR-3138 hsa-miR-1285 hsa-miR-421 hsa-miR-124 hsa-miR-342-5p hsa-miR-548x hsa-miR-205* hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidDDA1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat DDA1

    Additional mRNA sequence: 

    AL832922.1 AY563006.2 BC000615.2 DQ090952.1 

    9 DOTS entries:

    DT.446827  DT.100837505  DT.95242677  DT.100825312  DT.120788987  DT.100825315  DT.97845657  DT.91732791 
    DT.91859248 

    Selected AceView cDNA sequences (see all 317):

    BM129640 BM726463 BQ955369 BX457368 BI030860 BC000615 BF514995 CA495281 
    CA488788 AL832922 BM661618 BM910207 BM128561 CR614550 BI039370 BQ923586 
    BQ230161 BQ018728 AI816214 AI143995 BQ652029 BF475946 AI925348 BQ673955 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DDA1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
    SP1:                                                  -     -                     
    SP2:                                                  -     -     -               
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for DDA1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DDA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTAGTGCG
    DDA1 Expression
    About this image

    DDA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DDA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.466154
        Pathway & Disease-focused RT2 Profiler PCR Array including DDA1: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DDA1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dda11 , 5 DET1 and DDB1 associated 11, 5 86.27(n)1
    98.04(a)1
      8 (34.43 cM)5
    664981  NM_025600.11  NP_079876.11 
     714691995 
    chicken
    (Gallus gallus)
    Aves DDA11 DET1 and DDB1 associated 1 78.1(n)
    95.1(a)
      426942  NM_001031408.1  NP_001026579.1 
    lizard
    (Anolis carolinensis)
    Reptilia DDA16
    DET1 and DDB1 associated 1
    93(a)
    1 ↔ 1
    GL344948.1(1232-8033)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247362 Xenopus laevis transcribed sequence with moderate similarity more 77.34(n)    CB199002.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BC054628.12   -- 78.21(n)    BC054628.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG318556
    --
    38(a)
    1 ↔ 1
    2L(13369193-13370334)


    ENSEMBL Gene Tree for DDA1 (if available)
    TreeFam Gene Tree for DDA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DDA1 gene

    Find genes that share paralogs with DDA1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DDA1
    PGOHUM00000247789


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DDA1 (see all 436)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1477658521,2
    --17418390(+) TTCTGA/GTGCCT 1 -- us2k10--------
    rs769030311,2
    C,F--17418729(+) GGAAGG/ACAGTT 1 -- us2k12Minor allele frequency- A:0.13NA 122
    rs1922236571,2
    --17418744(+) CACAGA/TGGTGT 1 -- us2k10--------
    rs38102031,2
    C,F,H--17418859(+) TCTGGG/AAGAGC 1 -- us2k15Minor allele frequency- A:0.01NS EA NA 502
    rs1841767991,2
    --17418940(+) GGGGCC/TAAGGA 1 -- us2k10--------
    rs104063951,2
    C--17418981(+) GGTGGT/CTGAGC 1 -- us2k12Minor allele frequency- C:0.19WA 120
    rs72605731,2
    C,F,A,H--17419047(+) CTTTAA/GAAACG 1 -- us2k18Minor allele frequency- G:0.23NA WA EA 370
    rs1450989081,2
    --17419201(+) AGGGAG/TTTTAG 1 -- us2k10--------
    rs792817481,2
    F--17419268(+) CCTCCC/TGGGTT 1 -- us2k11Minor allele frequency- T:0.50NA 4
    rs793087751,2
    C--17419276(-) AATCAG/CCTGAA 1 -- us2k11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for DDA1 (17420327 - 17434110 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DDA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657177CNV Deletion23128226
    esv2718275CNV Deletion23290073
    esv1347676CNV Deletion17803354
    dgv3760n71CNV Loss21882294
    nsv911182CNV Loss21882294
    nsv911198CNV Loss21882294
    nsv911200CNV Loss21882294
    nsv470129CNV Loss18288195
    dgv3758n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DDA1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DDA1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with DDA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PubMed id 17452440)1, 2, 3 Pick E.... Wei N. (Mol. Cell. Biol. 2007)
    2. The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection. (PubMed id 23849790)1 Casey Klockow L....de Noronha C.M. (Virology 2013)
    3. Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. (PubMed id 23273568)1 Yang W....Lau Y.L. (Am. J. Hum. Genet. 2013)
    4. Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response. (PubMed id 22072767)1 Salsman J....Frappier L. (J. Virol. 2012)
    5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79016 HGNC: 28360 AceView: PCIA1 Ensembl:ENSG00000130311 euGenes: HUgn79016
    ECgene: DDA1 H-InvDB: DDA1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DDA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DDA1 gene:
    Search GeneIP for patents involving DDA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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