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Aliases for DDA1 Gene

Aliases for DDA1 Gene

  • DET1 And DDB1 Associated 1 2 3
  • Placenta Cross-Immune Reaction Antigen 1 3 4
  • C19orf58 3 4
  • PCIA-1 3 4
  • PCIA1 3 4
  • Chromosome 19 Open Reading Frame 58 2
  • DET1- And DDB1-Associated Protein 1 3
  • Cross-Immune Reaction Antigen PCIA1 3

External Ids for DDA1 Gene

Previous HGNC Symbols for DDA1 Gene

  • C19orf58

Previous GeneCards Identifiers for DDA1 Gene

  • GC19P017284
  • GC19P017420
  • GC19P016986

Summaries for DDA1 Gene

GeneCards Summary for DDA1 Gene

DDA1 (DET1 And DDB1 Associated 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DDA1 Gene

  • May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDA1 Gene

Genomics for DDA1 Gene

Regulatory Elements for DDA1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DDA1 Gene

17,309,518 bp from pter
17,323,301 bp from pter
13,784 bases
Plus strand

Genomic View for DDA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDA1 Gene

Proteins for DDA1 Gene

  • Protein details for DDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DET1- and DDB1-associated protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for DDA1 Gene

    102 amino acids
    Molecular mass:
    11835 Da
    Quaternary structure:
    • Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.

neXtProt entry for DDA1 Gene

Proteomics data for DDA1 Gene at MOPED

Post-translational modifications for DDA1 Gene

  • Ubiquitination at Lys71
  • Modification sites at PhosphoSitePlus

Other Protein References for DDA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DDA1

No data available for DME Specific Peptides for DDA1 Gene

Domains for DDA1 Gene

Protein Domains for DDA1 Gene

Suggested Antigen Peptide Sequences for DDA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DDA1 family.
  • Belongs to the DDA1 family.
genes like me logo Genes that share domains with DDA1: view

No data available for Gene Families for DDA1 Gene

Function for DDA1 Gene

Molecular function for DDA1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.

Gene Ontology (GO) - Molecular Function for DDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DDA1: view
genes like me logo Genes that share phenotypes with DDA1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDA1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DDA1 Gene

Localization for DDA1 Gene

Subcellular locations from

Jensen Localization Image for DDA1 Gene COMPARTMENTS Subcellular localization image for DDA1 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDA1 Gene

Pathways for DDA1 Gene

SuperPathways for DDA1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DDA1 Gene


No data available for Pathways by source for DDA1 Gene

Transcripts for DDA1 Gene

mRNA/cDNA for DDA1 Gene

Unigene Clusters for DDA1 Gene

DET1 and DDB1 associated 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DDA1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -

Relevant External Links for DDA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDA1 Gene

mRNA expression in normal human tissues for DDA1 Gene

Protein differential expression in normal tissues for DDA1 Gene

This gene is overexpressed in Lung (22.0), Placenta (7.4), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDA1 Gene

SOURCE GeneReport for Unigene cluster for DDA1 Gene Hs.466154

genes like me logo Genes that share expressions with DDA1: view

Expression partners for DDA1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDA1 Gene

Orthologs for DDA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDA1 35
  • 91.83 (n)
  • 100 (a)
DDA1 36
  • 100 (a)
MGC137055 36
  • 72 (a)
(Canis familiaris)
Mammalia DDA1 35
  • 91.18 (n)
  • 99.02 (a)
DDA1 36
  • 99 (a)
(Mus musculus)
Mammalia Dda1 35
  • 86.27 (n)
  • 98.04 (a)
Dda1 16
Dda1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dda1 35
  • 87.58 (n)
  • 98.04 (a)
(Monodelphis domestica)
Mammalia DDA1 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia DDA1 36
  • 80 (a)
(Pan troglodytes)
Mammalia DDA1 36
  • 100 (a)
(Gallus gallus)
Aves DDA1 35
  • 78.1 (n)
  • 95.1 (a)
DDA1 36
  • 95 (a)
(Anolis carolinensis)
Reptilia DDA1 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dda1 35
  • 77.56 (n)
  • 90.1 (a)
Str.6079 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24736 35
(Danio rerio)
Actinopterygii dda1 35
  • 78.22 (n)
  • 89.11 (a)
dda1 36
  • 87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5435 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008078 35
  • 58.33 (n)
  • 57.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31855 36
  • 38 (a)
Species with no ortholog for DDA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDA1 Gene

Gene Tree for DDA1 (if available)
Gene Tree for DDA1 (if available)

Paralogs for DDA1 Gene Pseudogenes for DDA1 Gene

genes like me logo Genes that share paralogs with DDA1: view

No data available for Paralogs for DDA1 Gene

Variants for DDA1 Gene

Sequence variations from dbSNP and Humsavar for DDA1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7888 -- 17,320,047(+) GGGGC(A/G)GGCCC utr-variant-3-prime
rs9234 -- 17,319,948(+) CCATC(A/G)GGCCA utr-variant-3-prime
rs10259 -- 17,320,106(-) CTGGA(C/T)CGGTG utr-variant-3-prime
rs13238 -- 17,320,037(+) CCGGG(C/T)GACAG utr-variant-3-prime
rs971693 -- 17,311,840(+) AGTGC(C/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDA1 Gene

Variant ID Type Subtype PubMed ID
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
dgv3760n71 CNV Loss 21882294
nsv911198 CNV Loss 21882294
nsv911200 CNV Loss 21882294
esv2718275 CNV Deletion 23290073
esv1347676 CNV Deletion 17803354
esv2657177 CNV Deletion 23128226

Relevant External Links for DDA1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDA1 Gene

Disorders for DDA1 Gene

No disorders were found for DDA1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DDA1 Gene

Publications for DDA1 Gene

  1. Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PMID: 17452440) Pick E. … Wei N. (Mol. Cell. Biol. 2007) 2 3 4
  2. [Searching for genes interacting with human PCIA1 gene by using the bacterial two-hybrid system]. (PMID: 17557237) Li Z.M. … Jia Y.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007) 3
  3. Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle. (PMID: 17609381) Hrecka K. … Skowronski J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3
  4. Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. (PMID: 18464893) Srivastava S. … Skowronski J. (PLoS Pathog. 2008) 3
  5. An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PMID: 19295130) Olma M.H. … Pintard L. (J. Cell. Sci. 2009) 3

Products for DDA1 Gene

Sources for DDA1 Gene

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