DDA1 Gene
protein-coding GIFtS: 43
GCID: GC19P017420
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DET1 and DDB1 associated 1(Previous name: chromosome 19 open reading frame 58 )
(Previous symbol: C19orf58)
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Aliases
for DDA1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DET1 And DDB1 Associated 11 2 | | MGC25941 | | C19orf581 2 3 | | Chromosome 19 Open Reading Frame 581 | | PCIA11 2 3 | | Cross-Immune Reaction Antigen PCIA12 | | Placenta Cross-Immune Reaction Antigen 12 3 | | DET1- And DDB1-Associated Protein 12 | | PCIA-12 3 | | |
Export aliases for DDA1 gene to outside databasesPrevious GC identifers: GC19P017284 GC19P016986 |
Summaries
for DDA1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DDA1_HUMAN, Q9BW61Function: May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of theDDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins
|
Genomic Views
for DDA1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DDA1 gene promoter:
C/EBPbeta AML1a AP-1 p53 MAZR SRF (504 AA) Olf-1 E47 GATA-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for DDA1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDA1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.11 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p13.11DDA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P017420: view genomic region
(about GC identifiers)
Start:
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17,420,337 bp from pter |
End:
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17,434,107 bp from pter |
Size:
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13,771 bases |
Orientation:
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plus strand |
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Proteins
for DDA1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DDA1_HUMAN, Q9BW61 (See
protein sequence)Recommended Name: DET1- and DDB1-associated protein 1 Size: 102 amino acids; 11835 Da
Subunit: Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2Eenzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexesExplore the universe of human proteins at neXtProt for DDA1: NX_Q9BW61
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BW61
DDA1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076955.1
ENSEMBL proteins: ENSP00000352928
Human Recombinant Protein Products:
DDA1 Antibody Products:
Assay Products for DDA1: |
Protein
Domains /
Families
for DDA1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DDA1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BW61ProtoNet protein and cluster: Q9BW61 UniProtKB/Swiss-Prot: DDA1_HUMAN, Q9BW61Similarity: Belongs to the DDA1 family |
Function
for DDA1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DDA1_HUMAN, Q9BW61Function: May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of theDDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DDA1 (NM_024050) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDA1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDA1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDA1 |
2 GenomeRNAi human phenotypes for DDA1:
|
Pathways & Interactions
for DDA1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DDA1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/621 Interacting proteins for DDA1 (Q9BW613 ENSP000003529284) via UniProtKB, MINT, STRING, and/or I2D (see all 621)About this table
|
Drugs & Compounds
for DDA1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DDA1
Search CenterWatch for drugs/clinical trials and news about DDA1
|
Transcripts
for DDA1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DDA1 gene: NM_024050.5 Unigene Cluster for DDA1: DET1 and DDB1 associated 1 Hs.466154 [show with all ESTs]Unigene Representative Sequence: NM_0240501 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000359866(uc002ngd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDA1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDA1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DDA1 (NM_024050) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DDA1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDA1 |
Additional cDNA sequence: AL832922.1 AY563006.2 BC000615.2 DQ090952.1 9 DOTS entries: DT.446827 DT.100837505 DT.95242677 DT.100825312 DT.120788987 DT.100825315 DT.97845657 DT.91732791 DT.91859248 24/317 AceView cDNA sequences (see all 317): AI925348 BM912431 AA861667 BM662473 AI566544 BI030860 BM687125 AI570603 BM673380 BF475946 BM090919 BU552541 AI190592 BQ955369 BX473050 BQ230161 AI337834 CR599345 BQ050744 BG232047 BQ920669 R56268 BC000615 BM661618
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for DDA1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DDA1
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Expression
for DDA1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DDA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTAGTGCG
About this image
See DDA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DDA1
SOURCE GeneReport for Unigene cluster: Hs.466154
SABiosciences Expression via Pathway-Focused PCR Array including DDA1:
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DDA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDA1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDA1 |
Orthologs
for DDA1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for DDA1 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for DDA1 (if available)
TreeFam Gene Tree for DDA1 (if available) |
Paralogs
for DDA1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DDA1 gene
DDA1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DDA1
PGOHUM00000247789
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Genomic Variants
for DDA1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DDA1 (17420337 - 17434107 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DDA1
2 CNVs: 30071 39226 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDA1 |
|
Disorders
/ Diseases
for DDA1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DDA1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DDA1 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with DDA1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PubMed id 17452440)1, 2, 3 Pick E.... Wei N. (2007)
- Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response. (PubMed id 22072767)1 Salsman J....Frappier L. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Myc protein is stabilized by suppression of a novel E 3 ligase complex in cancer cells. (PubMed id 20551172)1 Choi S.H....Cole M.D. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (2010)
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External Searches for DDA1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DDA1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DDA1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DDA1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DDA1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DDA1 gene:
Search GeneIP for patents involving DDA1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DDA1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DDA1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DDA1 | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for DDA1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DDA1 | | OriGene 3'-UTR Clone for DDA1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DDA1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DDA1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DDA1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DDA1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DDA1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DDA1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DDA1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DDA1 |
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| | | | Search Tocris compounds for DDA1 |
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 | | | DDA1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DDA1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DDA1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DDA1 |
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