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Aliases for DDA1 Gene

Aliases for DDA1 Gene

  • DET1 And DDB1 Associated 1 2 3 5
  • Placenta Cross-Immune Reaction Antigen 1 3 4
  • C19orf58 3 4
  • PCIA-1 3 4
  • PCIA1 3 4
  • Chromosome 19 Open Reading Frame 58 2
  • Cross-Immune Reaction Antigen PCIA1 3

External Ids for DDA1 Gene

Previous HGNC Symbols for DDA1 Gene

  • C19orf58

Previous GeneCards Identifiers for DDA1 Gene

  • GC19P017284
  • GC19P017420
  • GC19P016986
  • GC19P017421
  • GC19P017684

Summaries for DDA1 Gene

GeneCards Summary for DDA1 Gene

DDA1 (DET1 And DDB1 Associated 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DDA1 Gene

  • May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDA1 Gene

Genomics for DDA1 Gene

Regulatory Elements for DDA1 Gene

Enhancers for DDA1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DDA1 on UCSC Golden Path with GeneCards custom track

Promoters for DDA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DDA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DDA1 Gene

17,309,518 bp from pter
17,323,301 bp from pter
13,784 bases
Plus strand

Genomic View for DDA1 Gene

Genes around DDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDA1 Gene

Proteins for DDA1 Gene

  • Protein details for DDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DET1- and DDB1-associated protein 1
    Protein Accession:

    Protein attributes for DDA1 Gene

    102 amino acids
    Molecular mass:
    11835 Da
    Quaternary structure:
    • Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.

neXtProt entry for DDA1 Gene

Proteomics data for DDA1 Gene at MOPED

Post-translational modifications for DDA1 Gene

  • Ubiquitination at Lys 71
  • Modification sites at PhosphoSitePlus

Other Protein References for DDA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DDA1
  • Santa Cruz Biotechnology (SCBT) Antibodies for DDA1

No data available for DME Specific Peptides for DDA1 Gene

Domains & Families for DDA1 Gene

Protein Domains for DDA1 Gene

Suggested Antigen Peptide Sequences for DDA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DDA1 family.
  • Belongs to the DDA1 family.
genes like me logo Genes that share domains with DDA1: view

No data available for Gene Families for DDA1 Gene

Function for DDA1 Gene

Molecular function for DDA1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.
genes like me logo Genes that share phenotypes with DDA1: view

Animal Model Products

miRNA for DDA1 Gene

miRTarBase miRNAs that target DDA1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDA1 Gene

Localization for DDA1 Gene

Subcellular locations from

Jensen Localization Image for DDA1 Gene COMPARTMENTS Subcellular localization image for DDA1 gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DDA1 Gene

Pathways & Interactions for DDA1 Gene

SuperPathways for DDA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDA1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DDA1 Gene

Drugs & Compounds for DDA1 Gene

No Compound Related Data Available

Transcripts for DDA1 Gene

Unigene Clusters for DDA1 Gene

DET1 and DDB1 associated 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -

Relevant External Links for DDA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DDA1 Gene

mRNA expression in normal human tissues for DDA1 Gene

Protein differential expression in normal tissues from HIPED for DDA1 Gene

This gene is overexpressed in Lung (22.0), Placenta (7.4), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DDA1 Gene

SOURCE GeneReport for Unigene cluster for DDA1 Gene Hs.466154

genes like me logo Genes that share expression patterns with DDA1: view

Protein tissue co-expression partners for DDA1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DDA1 Gene

Orthologs for DDA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DDA1 35
  • 91.83 (n)
  • 100 (a)
DDA1 36
  • 100 (a)
MGC137055 36
  • 72 (a)
(Canis familiaris)
Mammalia DDA1 35
  • 91.18 (n)
  • 99.02 (a)
DDA1 36
  • 99 (a)
(Mus musculus)
Mammalia Dda1 35
  • 86.27 (n)
  • 98.04 (a)
Dda1 16
Dda1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dda1 35
  • 87.58 (n)
  • 98.04 (a)
(Monodelphis domestica)
Mammalia DDA1 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia DDA1 36
  • 80 (a)
(Pan troglodytes)
Mammalia DDA1 36
  • 100 (a)
(Gallus gallus)
Aves DDA1 35
  • 78.1 (n)
  • 95.1 (a)
DDA1 36
  • 95 (a)
(Anolis carolinensis)
Reptilia DDA1 36
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dda1 35
  • 77.56 (n)
  • 90.1 (a)
Str.6079 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24736 35
(Danio rerio)
Actinopterygii dda1 35
  • 78.22 (n)
  • 89.11 (a)
dda1 36
  • 87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5435 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008078 35
  • 58.33 (n)
  • 57.61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31855 36
  • 38 (a)
Species with no ortholog for DDA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDA1 Gene

Gene Tree for DDA1 (if available)
Gene Tree for DDA1 (if available)

Paralogs for DDA1 Gene Pseudogenes for DDA1 Gene

genes like me logo Genes that share paralogs with DDA1: view

No data available for Paralogs for DDA1 Gene

Variants for DDA1 Gene

Sequence variations from dbSNP and Humsavar for DDA1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7259941 -- 17,317,236(+) cgggc(A/G)cggtg intron-variant
rs7260573 -- 17,308,238(+) CTTTA(A/G)AAACG upstream-variant-2KB
rs8100232 -- 17,312,142(+) CCCTC(A/G)TCCCA intron-variant
rs8100448 -- 17,311,593(+) CCACT(A/C)TGTCT intron-variant
rs8100463 -- 17,312,335(+) ACCTC(A/G)CCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDA1 Gene

Variant ID Type Subtype PubMed ID
dgv3758n71 CNV Loss 21882294
nsv911182 CNV Loss 21882294
nsv470129 CNV Loss 18288195
dgv3760n71 CNV Loss 21882294
nsv911198 CNV Loss 21882294
nsv911200 CNV Loss 21882294
esv2718275 CNV Deletion 23290073
esv1347676 CNV Deletion 17803354
esv2657177 CNV Deletion 23128226

Variation tolerance for DDA1 Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.88% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DDA1 Gene

Disorders for DDA1 Gene

Relevant External Links for DDA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DDA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDA1 Gene

Publications for DDA1 Gene

  1. Mammalian DET1 regulates Cul4A Activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PMID: 17452440) Pick E. … Wei N. (Mol. Cell. Biol. 2007) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing. (PMID: 24412650) Laguette N. … Benkirane M. (Cell 2014) 3

Products for DDA1 Gene

Sources for DDA1 Gene