Aliases for DCX Gene
External Ids for DCX Gene
Previous GeneCards Identifiers for DCX Gene
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
GeneCards Summary for DCX Gene
DCX (Doublecortin) is a Protein Coding gene. Diseases associated with DCX include lissencephaly, x-linked and lissencephaly type 1 due to doublecortin gene mutation. Among its related pathways are Developmental Biology and Lissencephaly gene (LIS1) in neuronal migration and development. GO annotations related to this gene include protein kinase binding and calmodulin binding. An important paralog of this gene is STK33.
UniProtKB/Swiss-Prot for DCX Gene
Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.