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DCX Gene

protein-coding   GIFtS: 66
GCID: GC0XM110537

Doublecortin

(Previous names: doublecortex; lissencephaly, X-linked (doublecortin))
  See DCX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
doublecortin1 2     doublin2
DBCN2 3 5     lis-X2
LISX2 3 5     lissencephalin-X2
doublecortex1 2     Neuronal Migration Protein Doublecortin2
Doublecortex; Lissencephaly, X-Linked (Doublecortin)1     Doublin3
DC2     Lis-X3
SCLH2     Lissencephalin-X3
XLIS2     

External Ids:    HGNC: 27141   Entrez Gene: 16412   Ensembl: ENSG000000772797   OMIM: 3001215   UniProtKB: O436023   

Export aliases for DCX gene to outside databases

Previous GC identifers: GC0XM105840 GC0XM107683 GC0XM108562 GC0XM109300 GC0XM110343 GC0XM110423 GC0XM100159


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCX Gene:
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein
and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must
migrate over long distances to reach the site of their final differentiation. The encoded protein appears to
direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded
protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this
interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause
abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy,
mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth
brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Sep 2010)

GeneCards Summary for DCX Gene:
DCX (doublecortin) is a protein-coding gene. Diseases associated with DCX include subcortical laminal heteropia, x-linked, and dcx-related disorders. GO annotations related to this gene include microtubule binding and protein kinase binding. An important paralog of this gene is PNCK.

UniProtKB/Swiss-Prot: DCX_HUMAN, O43602
Function: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination
during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in
binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal
interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway.
May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration

Gene Wiki entry for DCX (Doublecortin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCX gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCX promoter sequence
   Search Chromatin IP Primers for DCX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq22.3-q23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq22.3-q23

DCX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCX gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM110537:  view genomic region     (about GC identifiers)

Start:
110,537,007 bp from pter      End:
110,655,603 bp from pter
Size:
118,597 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DCX_HUMAN, O43602 (See protein sequence)
Recommended Name: Neuronal migration protein doublecortin  
Size: 441 amino acids; 49318 Da
Subunit: Interacts with tubulin
4 PDB 3D structures from and Proteopedia for DCX:
1MJD (3D)        2BQQ (3D)        2XRP (3D)        4ATU (3D)    
Secondary accessions: A6NFY6 A9Z1V8 D3DUY8 D3DUY9 D3DUZ0 O43911 Q5JYZ5
Alternative splicing: 5 isoforms:  O43602-1   O43602-2   O43602-3   O43602-4   O43602-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCX: NX_O43602

Explore proteomics data for DCX at MOPED

Post-translational modifications: 

  • Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (By similarity)1
  • Phosphorylation at Ser-346 and Ser-378 seems to occur only in neonatal brain, the levels falling precipitously by
    postnatal day 21 (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DCX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000546.2  NP_001182482.1  NP_835364.1  NP_835365.1  NP_835366.1  

    ENSEMBL proteins: 
     ENSP00000350776   ENSP00000337697   ENSP00000348553   ENSP00000419861   ENSP00000418811  
     ENSP00000349385   ENSP00000361061  
    Reactome Protein details: O43602

    DCX Human Recombinant Protein Products:

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    OriGene Purified Proteins for DCX
    OriGene Protein Over-expression Lysate for DCX
    OriGene MassSpec for DCX
    OriGene Custom Protein Services for DCX
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    Novus Biologicals DCX Protein
    Novus Biologicals DCX Lysates
    Sino Biological Recombinant Protein for DCX
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCX

     
    Search eBioscience for Proteins for DCX 

     
    antibodies-online proteins for DCX (9 products) 

     
    antibodies-online peptides for DCX

    DCX Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DCX
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for DCX  (doublecortin)
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    Novus Biologicals DCX Antibodies
    Abcam antibodies for DCX
    Cloud-Clone Corp. Antibodies for DCX
    ThermoFisher Antibody for DCX
    antibodies-online antibodies for DCX (102 products) 

    DCX Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DCX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DCX
    Cloud-Clone Corp. CLIAs for DCX
    Search eBioscience for ELISAs for DCX 
    antibodies-online kits for DCX (30 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003533 Doublecortin_dom
     IPR017302 Doublecortin_chordata

    Graphical View of Domain Structure for InterPro Entry O43602

    ProtoNet protein and cluster: O43602

    1 Blocks protein domain: IPB003533 Doublecortin

    UniProtKB/Swiss-Prot: DCX_HUMAN, O43602
    Similarity: Contains 2 doublecortin domains


    Find genes that share domains with DCX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCX_HUMAN, O43602
    Function: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination
    during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in
    binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal
    interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway.
    May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration

         Genatlas biochemistry entry for DCX:
    doublecortin,microtubule associated protein,brain specific,intracellular signaling molecule,likely required for
    neural migration from the ventricular zone to the developing cortex and differentiation,involved in calcium
    dependent signaling of neuronal migration,expressed in multiple regions of embryonic brain including the
    developing cerebral cortex

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008017microtubule binding IDA14741102
    GO:0019901protein kinase binding IPI14741102
         
    Find genes that share ontologies with DCX           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DCX:
     Decreased viability with cispl  Increased number of cells in m  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Dcx):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  no phenotypic analysis 
     reproductive system 

    Find genes that share phenotypes with DCX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dcxtm1.2Ffr for DCX

       genOway: Develop your customized and physiologically relevant rodent model for DCX

    miRNA
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    miRTarBase miRNAs that target DCX:
    hsa-mir-128-3p (MIRT001070)

    Block miRNA regulation of human, mouse, rat DCX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCX (see all 220):
    hsa-miR-194* hsa-miR-26a-2* hsa-miR-128 hsa-miR-138-2* hsa-miR-3921 hsa-miR-342-3p hsa-miR-4275 hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DCX
    Predesigned siRNA for gene silencing in human, mouse, rat DCX

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for DCX (see all 32)
    OriGene ORF clones in mouse, rat for DCX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): DCX (NM_001195553)
    Sino Biological Human cDNA Clone for DCX
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCX
    Addgene plasmids for DCX 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DCX 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCX_HUMAN, O43602: Cytoplasm. Cell projection (By similarity). Note=Localizes at neurite tips (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    nucleus3
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS11001923
    GO:0005874microtubule IEA--
    GO:0005875microtubule associated complex TAS11001923

    Find genes that share ontologies with DCX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCX About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    Neurofascin interactions0.00
    2TGF-Beta Pathway
    JNK Pathway0.51
    3Neuroscience
    Neuroscience
    4Lissencephaly gene (LIS1) in neuronal migration and development
    Lissencephaly gene (LIS1) in neuronal migration and development
    5Cytoskeletal Signaling
    Cytoskeletal Signaling


    Find genes that share SuperPaths with DCX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DCX
        JNK Pathway

    2 Cell Signaling Technology (CST) Pathways for DCX
        Neuroscience
    Cytoskeletal Signaling

    1 BioSystems Pathway for DCX
        Lissencephaly gene (LIS1) in neuronal migration and development


    1 Reactome Pathway for DCX
        Neurofascin interactions


        Pathway & Disease-focused RT2 Profiler PCR Arrays including DCX: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DCX

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for DCX (O436023 ENSP000003376974) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM39Q9HCM93, ENSP000003658444I2D: score=1 STRING: ENSP00000365844
    ENSG00000206495Q9HCM93I2D: score=1 
    ENSG00000224994Q9HCM93I2D: score=1 
    ENSG00000226437Q9HCM93I2D: score=1 
    ENSG00000229929Q9HCM93I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IDA14741102
    GO:0007399nervous system development TAS9489699
    GO:0007411axon guidance TAS--
    GO:0007417central nervous system development TAS9489699
    GO:0007420brain development IEA--

    Find genes that share ontologies with DCX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCX

    1 HMDB Compound for DCX    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    5 Novoseek inferred chemical compound relationships for DCX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bromodeoxyuridine 67.2 22 12812760 (1), 15023573 (1), 17854417 (1), 20025852 (1) (see all 14)
    kainate 24.8 2 16624297 (1), 16641251 (1)
    calcium 0 2 10550327 (1)
    serine 0 1 9817918 (1)
    vegf 0 1 15178821 (1)



    Find genes that share compounds with DCX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCX gene (5 alternative transcripts): 
    NM_000555.3  NM_001195553.1  NM_178151.2  NM_178152.2  NM_178153.2  

    Unigene Cluster for DCX:

    Doublecortin
    Hs.34780  [show with all ESTs]
    Unigene Representative Sequence: NM_000555
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358070 ENST00000338081(uc004epd.3 uc011msv.2) ENST00000356220
    ENST00000488120 ENST00000496551 ENST00000468911 ENST00000356915(uc004epf.3 uc004epg.3)
    ENST00000371993(uc004epe.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat DCX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCX (see all 220):
    hsa-miR-194* hsa-miR-26a-2* hsa-miR-128 hsa-miR-138-2* hsa-miR-3921 hsa-miR-342-3p hsa-miR-4275 hsa-miR-3916
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Addgene plasmids for DCX 
    Primer
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    OriGene qPCR primer pairs and template standards for DCX
    OriGene qSTAR qPCR primer pairs in human, mouse for DCX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCX
      QuantiTect SYBR Green Assays in human, mouse, rat DCX
      QuantiFast Probe-based Assays in human, mouse, rat DCX

    Additional mRNA sequence: 

    AF034634.1 AF040254.1 AF040255.1 AK002120.1 AK290455.1 AK297297.1 BC027925.1 

    7 DOTS entries:

    DT.95366810  DT.92421438  DT.417323  DT.121323776  DT.100784134  DT.121323767  DT.95366813 

    Selected AceView cDNA sequences (see all 115):

    AL134341 D59885 AA133236 BI522791 AA676664 AA932391 NM_178152 D80599 
    BM722413 NM_178153 BU741997 AI553841 AI654908 BX505302 AA460623 BC027925 
    AI937317 AA455927 AI879528 AW160376 AA447721 AU120758 D81042 AW163329 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCX (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c
    SP1:              -     -     -                                                     -                           
    SP2:                                                                                -                           
    SP3:                                                                                                            
    SP4:              -     -     -                                                                                 
    SP5:                    -     -                                                                                 


    ECgene alternative splicing isoforms for DCX

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTAAGGT
    DCX Expression
    About this image


    DCX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Endothelial Cells Blood Brain Barrier
             Cerebellum
             Neural progenitor cells
     
     Eye (Sensory Organs)    fully expand to see all 5 entries
             Mature Horizontal Cells Inner Nuclear Layer
             Retinal Pigmented Epithelium
     
     Neurons
             Mature Horizontal Cells Inner Nuclear Layer
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
    DCX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.34780

    UniProtKB/Swiss-Prot: DCX_HUMAN, O43602
    Tissue specificity: Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical
    plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly
    expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in
    heart, placenta, lung, liver, skeletal muscles, kidney and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DCX: 
              Neurogenesis in human mouse rat
              Cell Lineage Identification in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DCX
    OriGene qSTAR qPCR primer pairs in human, mouse for DCX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCX
    QuantiTect SYBR Green Assays in human, mouse, rat DCX
    QuantiFast Probe-based Assays in human, mouse, rat DCX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DCX gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcx1 , 5 doublecortin1, 5 89.72(n)1
    99.44(a)1
      X (64.89 cM)5
    131931  NM_001110223.11  NP_001103693.11 
     1438558425 
    chicken
    (Gallus gallus)
    Aves DCX1 doublecortin 85.09(n)
    96.39(a)
      374242  NM_204335.1  NP_989666.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCX6
    doublecortin
    88(a)
    1 ↔ 1
    4(125741547-125742855)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dcx1 doublecortin 79.61(n)
    91.9(a)
      100493401  XM_004916847.1  XP_004916904.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-290k24.16
    si:ch73-290k24.1
    27(a)
    many ↔ many
    23(45901894-45934726) ENSDARG00000079882
    fruit fly
    (Drosophila melanogaster)
    Insecta CG175286
    --
    18(a)
    1 → many
    2R(704674-711821)
    worm
    (Caenorhabditis elegans)
    Secernentea zyg-86
    Protein ZYG-8 (zyg-8) mRNA, complete cds
    16(a)
    1 → many
    III(12061739-12072276) WBGene00006993


    ENSEMBL Gene Tree for DCX (if available)
    TreeFam Gene Tree for DCX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCX gene
    PNCK2  CAMK1G2  PSKH22  DCLK22  CAMK2A2  CAMK1D2  DCLK12  PSKH12  
    CAMK42  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    2 SIMAP similar genes for DCX using alignment to 3 protein entries:     DCX_HUMAN (see all proteins):
    DCLK1    DCLK2

    Find genes that share paralogs with DCX           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCX (see all 1610)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs560303721,2,,4
    CLissencephaly, X-linked 1 (LISX1)4 pathogenic1110624379(-) TGTGCA/GTGTGC 10 H R mis10--------
    VAR_0260334
    Subcortical band heterotopia X-linked (SBHX)4--see VAR_0260332 N I mis40--------
    VAR_0078274
    Lissencephaly, X-linked 1 (LISX1)4--see VAR_0078272 R S mis40--------
    VAR_0260344
    Subcortical band heterotopia X-linked (SBHX)4--see VAR_0260342 T A mis40--------
    VAR_0078384
    Subcortical band heterotopia X-linked (SBHX)4--see VAR_0078382 G E mis40--------
    VAR_0078264
    Subcortical band heterotopia X-linked (SBHX)4--see VAR_0078262 G A mis40--------
    VAR_0078214
    Subcortical band heterotopia X-linked (SBHX)4--see VAR_0078212 R L mis40--------
    VAR_0260244
    Lissencephaly, X-linked 1 (LISX1)4--see VAR_0260242 N D mis40--------
    VAR_0260304
    Subcortical band heterotopia X-linked (SBHX)4--see VAR_0260302 P L mis40--------
    VAR_0078244
    Subcortical band heterotopia X-linked (SBHX)4--see VAR_0078242 R L mis40--------

    HapMap Linkage Disequilibrium report for DCX (110537007 - 110655603 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DCX:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677714CNV Deletion23128226
    nsv7038CNV Insertion18451855

    Human Gene Mutation Database (HGMD): DCX
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCX
    DNA2.0 Custom Variant and Variant Library Synthesis for DCX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 300121   
    OMIM disorders: 300067  
    UniProtKB/Swiss-Prot: DCX_HUMAN, O43602
  • Lissencephaly, X-linked 1 (LISX1) [MIM:300067]: A classic lissencephaly characterized by mental
    retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex
    with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone,
    seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred
    to as 'doublecortex'. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Subcortical band heterotopia X-linked (SBHX) [MIM:300067]: SBHX is a mild brain malformation of the
    lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in
    the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing
    normal. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=A chromosomal aberration involving DCX is found in lissencephaly. Translocation t(X;2)(q22.3;p25.1)

  • 15 diseases for DCX:    
    About MalaCards
    subcortical laminal heteropia, x-linked    dcx-related disorders    subcortical band heterotopia    lissencephaly x-linked
    stargardt disease 4    lissencephaly    pachygyria    periventricular nodular heterotopia
    neuronal migration disorders    subcortical laminar heterotopia    lennox-gastaut syndrome    ganglioneuroma
    status epilepticus    stargardt disease    pilocytic astrocytoma

    5 diseases from the University of Copenhagen DISEASES database for DCX:
    Lissencephaly     Periventricular nodular heterotopia     Intellectual disability     Cerebrovascular accident
    Focal epilepsy

    Find genes that share disorders with DCX           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DCX gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lissencephaly, x-linked 96.9 23 9097958 (2), 9489700 (2), 10369164 (1), 12223548 (1) (see all 20)
    lissencephaly sequence, isolated 86.7 8 12552055 (1), 11429281 (1), 10494089 (1), 11262729 (1) (see all 7)
    periventricular nodular heterotopia 83.1 1 16538086 (1)
    cerebellar hypoplasia 75.9 1 16538086 (1)
    epilepsy 59.7 9 12027577 (1), 18575605 (1), 16957770 (1), 19144832 (1) (see all 9)
    mental retardation 52.5 6 18575605 (1), 16957770 (1), 19144832 (1), 15632197 (1) (see all 6)
    tuberous sclerosis 47.7 1 12200630 (1)
    ganglioglioma 45.4 4 12200628 (2), 16520969 (1)
    zellweger syndrome 40.2 2 10963364 (2)
    pilocytic astrocytoma 31.6 1 16520969 (1)

    Genatlas disease: DCX
    lissencephaly syndrome 2 (or smooth brain),neuronal migration disorder resulting,associated with agenesis of
    corpus callosum,resulting in mixed agyria and pachygyria associated with agenesis of corpus
    callosum,characterized by epilepsy and mental retardation,including mild form in heterozygote female with mental
    retardation and subcortical band heterotopia (double cortex)

    GeneTests: DCX
    GeneReviews: DCX
    Genetic Association Database (GAD): DCX
    Human Genome Epidemiology (HuGE) Navigator: DCX (3 documents)

    Export disorders for DCX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for DCX gene, integrated from 10 sources (see all 222):
    (articles sorted by number of sources associating them with DCX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. (PubMed id 9489700)1, 2, 3, 9 Gleeson J.G....Walsh C.A. (Cell 1998)
    2. A novel CNS gene required for neuronal migration and involved in X- linked subcortical laminar heterotopia and lissencephaly syndrome. (PubMed id 9489699)1, 2, 3 Des Portes V.... Chelly J. (Cell 1998)
    3. LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation. (PubMed id 9817918)1, 2, 9 Pilz D.T....Ross M.E. (Hum. Mol. Genet. 1998)
    4. The DCX-domain tandems of doublecortin and doublecortin-like kinase. (PubMed id 12692530)1, 2, 9 Kim M.H....Derewenda Z.S. (Nat. Struct. Biol. 2003)
    5. Human doublecortin (DCX) and the homologous gene in mouse encode a putative Ca2+-dependent signaling protein which is mutated in human X- linked neuronal migration defects. (PubMed id 9668176)1, 2, 9 Sossey-Alaoui K.... Srivastava A.K. (Hum. Mol. Genet. 1998)
    6. Doublecortin is the major gene causing X-linked subcortical laminar heterotopia (SCLH). (PubMed id 9618162)1, 2, 9 Des Portes V.... Beldjord C. (Hum. Mol. Genet. 1998)
    7. Characterization of mutations in the gene doublecortin in patients with double cortex syndrome. (PubMed id 9989615)1, 2, 9 Gleeson J.G....Walsh C.A. (Ann. Neurol. 1999)
    8. Subcortical band heterotopia in rare affected males can be caused by missense mutations in DCX (XLIS) or LIS1. (PubMed id 10441340)1, 2, 9 Pilz D.T.... Ledbetter D.H. (Hum. Mol. Genet. 1999)
    9. Somatic mosaicism and variable penetrance in doublecortin-associated migration disorders. (PubMed id 12552055)1, 2, 9 Aigner L.... Winkler J. (Neurology 2003)
    10. Subcortical band heterotopia (SBH) in males: clinical, imaging and genetic findings in comparison with females. (PubMed id 12390976)1, 2, 9 D'Agostino M.D.... Andermann E. (Brain 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1641 HGNC: 2714 AceView: DCX Ensembl:ENSG00000077279 euGenes: HUgn1641
    ECgene: DCX H-InvDB: DCX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DCX Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=DCX[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCX gene:
    Search GeneIP for patents involving DCX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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