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Aliases for DCUN1D5 Gene

Aliases for DCUN1D5 Gene

  • Defective In Cullin Neddylation 1 Domain Containing 5 2 3
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 5 3 5
  • Defective In Cullin Neddylation Protein 1-Like Protein 5 3 4
  • DCUN1 Domain-Containing Protein 5 3 4
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 5 (S. Cerevisiae) 2
  • SCCRO5 3

External Ids for DCUN1D5 Gene

Previous GeneCards Identifiers for DCUN1D5 Gene

  • GC11M102439
  • GC11M102932
  • GC11M098850
  • GC11M102923
  • GC11M102924

Summaries for DCUN1D5 Gene

GeneCards Summary for DCUN1D5 Gene

DCUN1D5 (Defective In Cullin Neddylation 1 Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is DCUN1D1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D5 Gene

Genomics for DCUN1D5 Gene

Regulatory Elements for DCUN1D5 Gene

Promoters for DCUN1D5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCUN1D5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCUN1D5 Gene

103,050,684 bp from pter
103,092,215 bp from pter
41,532 bases
Minus strand

Genomic View for DCUN1D5 Gene

Genes around DCUN1D5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCUN1D5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCUN1D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D5 Gene

Proteins for DCUN1D5 Gene

  • Protein details for DCUN1D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DCN1-like protein 5
    Protein Accession:
    Secondary Accessions:
    • Q3ZTT2

    Protein attributes for DCUN1D5 Gene

    237 amino acids
    Molecular mass:
    27508 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ76805.1; Type=Frameshift; Positions=222, 232; Evidence={ECO:0000305};

neXtProt entry for DCUN1D5 Gene

Proteomics data for DCUN1D5 Gene at MOPED

Post-translational modifications for DCUN1D5 Gene

  • Ubiquitination at Lys 139 and Lys 194
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCUN1D5 Gene

Domains & Families for DCUN1D5 Gene

Protein Domains for DCUN1D5 Gene


Suggested Antigen Peptide Sequences for DCUN1D5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DCUN1 domain.
  • Contains 1 DCUN1 domain.
genes like me logo Genes that share domains with DCUN1D5: view

No data available for Gene Families for DCUN1D5 Gene

Function for DCUN1D5 Gene

Gene Ontology (GO) - Molecular Function for DCUN1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with DCUN1D5: view
genes like me logo Genes that share phenotypes with DCUN1D5: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D5 Gene

Localization for DCUN1D5 Gene

Subcellular locations from

Jensen Localization Image for DCUN1D5 Gene COMPARTMENTS Subcellular localization image for DCUN1D5 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCUN1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with DCUN1D5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D5 Gene

Pathways & Interactions for DCUN1D5 Gene

SuperPathways for DCUN1D5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D5 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCUN1D5 Gene

Drugs & Compounds for DCUN1D5 Gene

No Compound Related Data Available

Transcripts for DCUN1D5 Gene

Unigene Clusters for DCUN1D5 Gene

DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for DCUN1D5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCUN1D5 Gene

mRNA expression in normal human tissues for DCUN1D5 Gene

Protein differential expression in normal tissues from HIPED for DCUN1D5 Gene

This gene is overexpressed in Bone (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCUN1D5 Gene

SOURCE GeneReport for Unigene cluster for DCUN1D5 Gene Hs.503716

genes like me logo Genes that share expression patterns with DCUN1D5: view

Protein tissue co-expression partners for DCUN1D5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCUN1D5 Gene

Orthologs for DCUN1D5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCUN1D5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCUN1D5 35
  • 100 (n)
  • 100 (a)
DCUN1D5 36
  • 100 (a)
(Bos Taurus)
Mammalia DCUN1D5 36
  • 99 (a)
DCUN1D5 35
  • 96.89 (n)
  • 98.73 (a)
(Canis familiaris)
Mammalia DCUN1D5 35
  • 95.92 (n)
  • 98.73 (a)
DCUN1D5 36
  • 99 (a)
(Mus musculus)
Mammalia Dcun1d5 16
Dcun1d5 35
  • 93.67 (n)
  • 96.62 (a)
Dcun1d5 36
  • 97 (a)
(Monodelphis domestica)
Mammalia DCUN1D5 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia DCUN1D5 36
  • 84 (a)
(Rattus norvegicus)
Mammalia Dcun1d5 35
  • 93.95 (n)
  • 97.05 (a)
(Gallus gallus)
Aves DCUN1D5 36
  • 93 (a)
DCUN1D5 35
  • 88.7 (n)
  • 92.8 (a)
(Anolis carolinensis)
Reptilia DCUN1D5 36
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7272 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dcun1d5 35
  • 80.38 (n)
  • 89.18 (a)
Str.20280 35
(Danio rerio)
Actinopterygii dcun1d5 36
  • 74 (a)
dcun1d5 35
  • 75.04 (n)
  • 80.09 (a)
Dr.28279 35
fruit fly
(Drosophila melanogaster)
Insecta CG6597 36
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2971 36
  • 49 (a)
Species with no ortholog for DCUN1D5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCUN1D5 Gene

Gene Tree for DCUN1D5 (if available)
Gene Tree for DCUN1D5 (if available)

Paralogs for DCUN1D5 Gene

Paralogs for DCUN1D5 Gene

genes like me logo Genes that share paralogs with DCUN1D5: view

Variants for DCUN1D5 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12999 -- 103,062,228(+) AAAAA(G/T)GAAAA utr-variant-3-prime
rs508674 -- 103,074,410(-) caaac(A/C)aacaC intron-variant
rs509491 -- 103,079,679(+) cttga(A/G)aggct intron-variant
rs510396 -- 103,086,323(+) atttg(A/G)gttct intron-variant
rs726316 -- 103,088,416(+) TATAT(A/G)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D5 Gene

Variant ID Type Subtype PubMed ID
nsv832253 CNV Gain 17160897
nsv483025 CNV Loss 15286789
nsv468855 CNV Loss 19166990
dgv1305n71 CNV Loss 21882294

Variation tolerance for DCUN1D5 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCUN1D5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D5 Gene

Disorders for DCUN1D5 Gene

Relevant External Links for DCUN1D5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCUN1D5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCUN1D5 Gene

Publications for DCUN1D5 Gene

  1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T. … Peter M. (Nature 2005) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis M.C. … He K. (Hum. Mol. Genet. 2015) 3
  5. Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization. (PMID: 24192928) BommeljAc C.C. … Singh B. (Clin. Cancer Res. 2014) 3

Products for DCUN1D5 Gene

Sources for DCUN1D5 Gene

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