DCUN1D5 Gene
protein-coding GIFtS: 45
GCID: GC11M102923
|
|
DCN1, defective in cullin neddylation 1, domain containing...
| |
Aliases
for DCUN1D5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DCN1, Defective In Cullin Neddylation 1, Domain Containing 5 (S.Cerevisiae)1 2 | | Defective In Cullin Neddylation Protein 1-Like Protein 52 3 | | DCUN1 Domain-Containing Protein 52 3 | | FLJ324311 | | MGC27141 | | DCN1-Like Protein 52 |
Export aliases for DCUN1D5 gene to outside databasesPrevious GC identifers: GC11M102439 GC11M102932 GC11M098850 |
Summaries
for DCUN1D5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DCUN1D5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DCUN1D5 gene promoter:
c-Fos ATF-2 MEF-2 FOXD3 MEF-2A CRE-BP1 aMEF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCUN1D5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3DCUN1D5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M102923: view genomic region
(about GC identifiers)
Start:
|
102,921,413 bp from pter |
End:
|
102,962,944 bp from pter |
Size:
|
41,532 bases |
Orientation:
|
minus strand |
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Proteins
for DCUN1D5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCNL5_HUMAN, Q9BTE7 (See
protein sequence)Recommended Name: DCN1-like protein 5 Size: 237 amino acids; 27508 Da
Sequence caution: Sequence=AAQ76805.1; Type=Frameshift; Positions=222, 232;
Secondary accessions: Q3ZTT2Explore the universe of human proteins at neXtProt for DCUN1D5: NX_Q9BTE7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BTE7
DCUN1D5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115675.1
ENSEMBL proteins: ENSP00000432027 ENSP00000260247 ENSP00000433073 ENSP00000435035 ENSP00000431311 ENSP00000433134 ENSP00000433344 ENSP00000432488 ENSP00000463796 ENSP00000437260 ENSP00000434336
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
DCUN1D5 for ontologies About GeneDecksing
DCUN1D5 Antibody Products:
Assay Products for DCUN1D5: |
Protein
Domains /
Families
for DCUN1D5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCUN1D5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BTE7ProtoNet protein and cluster: Q9BTE7 UniProtKB/Swiss-Prot: DCNL5_HUMAN, Q9BTE7Similarity: Contains 1 DCUN1 domain |
Function
for DCUN1D5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
DCUN1D5 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DCUN1D5:
|
Pathways & Interactions
for DCUN1D5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCUN1D5
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for DCUN1D5 (Q9BTE73 ENSP000002602474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
DCUN1D5 for ontologies About GeneDecksing
|
Drugs & Compounds
for DCUN1D5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCUN1D5
Search CenterWatch for drugs/clinical trials and news about DCUN1D5 / DCNL5
|
Transcripts
for DCUN1D5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCUN1D5 gene: NM_032299.3 Unigene Cluster for DCUN1D5: DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) Hs.503716 [show with all ESTs]Unigene Representative Sequence: NM_03229912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000527260 ENST00000260247(uc001phm.3) ENST00000531571(uc010ruw.2)
ENST00000531543 ENST00000529281 ENST00000529294 ENST00000527576 ENST00000527779
ENST00000583974 ENST00000525420 ENST00000525454 ENST00000529076
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCUN1D5 (NM_032299) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF086195.1 AK056993.1 AK094744.1 AK298227.1 AY364246.1 BC004169.2 BC021074.1 BX648187.1 21 DOTS entries: DT.212627 DT.100009095 DT.99940780 DT.91753268 DT.100796234 DT.95213621 DT.204438 DT.40278853 DT.95150177 DT.100796240 DT.75145347 DT.75178755 DT.97845756 DT.99956733 DT.120714743 DT.120744690 DT.120760675 DT.95213622 DT.95213627 DT.97845758 DT.75123391 24/254 AceView cDNA sequences (see all 254): BE888955 CR625928 CA455200 CR602483 AI948835 BE397321 BU845614 BU859384 BU182055 AI962602 AA583830 BM563001 BQ648864 AI767753 CB129919 BU902674 BM841562 CR599845 AA186873 CR619246 AL527399 CN481423 AK056993 BM846688
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DCUN1D5
|
Expression
for DCUN1D5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCUN1D5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATGGGCAT
About this image
See DCUN1D5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCUN1D5
SOURCE GeneReport for Unigene cluster: Hs.503716
SABiosciences Custom PCR Arrays for DCUN1D5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCUN1D5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCUN1D5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCUN1D5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCUN1D5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D5 |
Orthologs
for DCUN1D5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DCUN1D5 gene from 7/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DCUN1D51 |
DCN1, defective in cullin neddylation 1, domain containing more |
88.7(n)
92.8(a) |
|
418980 XM_417174.3 XP_417174.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DCUN1D56 |
-- |
90(a) |
1 ↔ 1 |
3(191953647-191978920) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.72722 |
Xenopus laevis transcribed sequence with moderate similarity more |
82.17(n) |
|
BX854190.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.282792 |
Danio rerio cDNA clone MGC65817 IMAGE6793074, complete more |
78.79(n) |
|
BC056731.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG65976 |
-- |
53(a) |
1 → many |
3L(20295531-20302611) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G158606 |
uncharacterized protein |
28(a) |
1 → many |
1(5454785-5457022) |
rice
(Oryza sativa) |
Liliopsida |
-- |
DCN1, putative, expressed |
28(a) |
1 → many |
8(21352670-21358025) |
ENSEMBL Gene Tree for DCUN1D5 (if available)
TreeFam Gene Tree for DCUN1D5 (if available) |
Paralogs
for DCUN1D5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DCUN1D5 gene
- DCUN1D42 DCUN1D12 DCUN1D32 DCUN1D22
4 SIMAP similar genes for DCUN1D5 using alignment to 10 protein entries: DCNL5_HUMAN (see all proteins):DCUN1D4 DCUN1D2 DCUN1D1 DCUN1D3
DCUN1D5 for paralogs About GeneDecksing
|
Genomic Variants
for DCUN1D5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCUN1D5 (102921413 - 102962944 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DCUN1D5
2 CNVs: 0155 85983 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCUN1D5 |
|
Disorders
/ Diseases
for DCUN1D5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 DCUN1D5 for disorders About MalaCards
DCUN1D5 for disorders About GeneDecksing
1 disease from the University of Copenhagen DISEASES database for DCUN1D5:Laryngeal squamous cell carcinoma Export disorders for DCUN1D5 gene to outside databases
|
Publications
for DCUN1D5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCUN1D5 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with DCUN1D5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PubMed id 15988528)1, 3 Kurz T....Peter M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for DCUN1D5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCUN1D5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCUN1D5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCUN1D5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCUN1D5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCUN1D5 gene:
Search GeneIP for patents involving DCUN1D5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCUN1D5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | DCUN1D5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D5 |
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