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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCUN1D5 Gene

protein-coding   GIFtS: 44
GCID: GC11M102924

DCN1, Defective In Cullin Neddylation 1, Domain Containing...

(Previous names: DCN1, defective in cullin neddylation 1, domain containing...)
  Search for DCUN1D5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DCN1, Defective In Cullin Neddylation 1, Domain Containing 51 2
Defective In Cullin Neddylation Protein 1-Like Protein 52 3
DCUN1 Domain-Containing Protein 52 3
DCN1, Defective In Cullin Neddylation 1, Domain Containing 5 (S.
Cerevisiae)1
DCN1-Like Protein 52

External Ids:    HGNC: 284091   Entrez Gene: 842592   Ensembl: ENSG000001376927   UniProtKB: Q9BTE73   

Export aliases for DCUN1D5 gene to outside databases

Previous GC identifers: GC11M102439 GC11M102932 GC11M098850 GC11M102923


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DCUN1D5 Gene: 
DCUN1D5 (DCN1, defective in cullin neddylation 1, domain containing 5) is a protein-coding gene. GO annotations related to this gene include molecular_function. An important paralog of this gene is DCUN1D4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCUN1D5 gene promoter:
         c-Fos   ATF-2   MEF-2   FOXD3   MEF-2A   CRE-BP1   aMEF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCUN1D5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCUN1D5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

DCUN1D5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCUN1D5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M102924:  view genomic region     (about GC identifiers)

Start:
102,921,413 bp from pter      End:
102,962,944 bp from pter
Size:
41,532 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCNL5_HUMAN, Q9BTE7 (See protein sequence)
Recommended Name: DCN1-like protein 5  
Size: 237 amino acids; 27508 Da
Sequence caution: Sequence=AAQ76805.1; Type=Frameshift; Positions=222, 232;
Secondary accessions: Q3ZTT2

Explore the universe of human proteins at neXtProt for DCUN1D5: NX_Q9BTE7

Explore proteomics data for DCUN1D5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BTE7

  • DCUN1D5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCUN1D5 Protein Expression
    REFSEQ proteins: NP_115675.1  
    ENSEMBL proteins: 
     ENSP00000432027   ENSP00000260247   ENSP00000433073   ENSP00000435035   ENSP00000431311  
     ENSP00000433134   ENSP00000433344   ENSP00000432488   ENSP00000463796   ENSP00000437260  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    DCUN1D5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR005176 PONY_dom
     IPR014764 DCN-prot

    Graphical View of Domain Structure for InterPro Entry Q9BTE7

    ProtoNet protein and cluster: Q9BTE7

    UniProtKB/Swiss-Prot: DCNL5_HUMAN, Q9BTE7
    Similarity: Contains 1 DCUN1 domain


    DCUN1D5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    DCUN1D5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DCUN1D5:
     Decreased number of cells in m 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCUN1D5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for DCUN1D5 (Q9BTE73 ENSP000002602474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SUMO2ENSP000004059654STRING: ENSP00000405965
    RCHY1ENSP000003212394STRING: ENSP00000321239
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    DCUN1D5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCUN1D5 (DCNL5)

    Search CenterWatch for drugs/clinical trials and news about DCUN1D5 / DCNL5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCUN1D5 gene: 
    NM_032299.3  

    Unigene Cluster for DCUN1D5:

    DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
    Hs.503716  [show with all ESTs]
    Unigene Representative Sequence: NM_032299
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527260 ENST00000260247(uc001phm.3) ENST00000531571(uc010ruw.2)
    ENST00000531543 ENST00000529281 ENST00000529294 ENST00000527576 ENST00000527779
    ENST00000583974 ENST00000525420 ENST00000529076
    miRNA
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    hsa-miR-411* hsa-miR-579 hsa-miR-520f hsa-miR-361-5p hsa-miR-128 hsa-miR-3653 hsa-miR-502-3p hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidDCUN1D5 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF086195.1 AK056993.1 AK094744.1 AK298227.1 AY364246.1 BC004169.2 BC021074.1 BX648187.1 

    21 DOTS entries:

    DT.212627  DT.100009095  DT.99940780  DT.91753268  DT.100796234  DT.95213621  DT.204438  DT.40278853 
    DT.95150177  DT.100796240  DT.75145347  DT.75178755  DT.97845756  DT.99956733  DT.120714743  DT.120744690 
    DT.120760675  DT.95213622  DT.95213627  DT.97845758  DT.75123391 

    24/254 AceView cDNA sequences (see all 254):

    AL559387 CR606085 CR625325 CR619246 BG283627 AI767753 BM741543 CB129919 
    BQ649694 CR601995 CN481423 AK056993 BQ652992 BU859384 BQ680253 AI948835 
    BM841562 CR590369 CA455200 BQ682473 CR602483 BM723994 AL527399 AA186873 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D5    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                    -                                                               
    SP2:                                      -                                             
    SP3:                    -                 -                                             
    SP4:                    -     -                                                         


    ECgene alternative splicing isoforms for DCUN1D5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCUN1D5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGGGCAT
    DCUN1D5 Expression
    About this image


    See DCUN1D5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCUN1D5

    SOURCE GeneReport for Unigene cluster: Hs.503716
        SABiosciences Custom PCR Arrays for DCUN1D5
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DCUN1D5 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcun1d51 , 5 DCN1, defective in cullin neddylation 1, domain containing more1, 5 93.67(n)1
    96.62(a)1
      9 (2.46 cM)5
    768631  NM_029775.21  NP_084051.11 
     71845665 
    chicken
    (Gallus gallus)
    Aves DCUN1D51 DCN1, defective in cullin neddylation 1, domain containing more 88.7(n)
    92.8(a)
      418980  XM_417174.3  XP_417174.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCUN1D56
    Uncharacterized protein
    91(a)
    1 ↔ 1
    3(191953272-191978920)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.72722 Xenopus laevis transcribed sequence with moderate similarity more 82.17(n)    BX854190.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.282792 Danio rerio cDNA clone MGC65817 IMAGE6793074, complete more 78.79(n)    BC056731.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65976
    --
    53(a)
    1 → many
    3L(20295531-20302611)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCN16
    Scaffold-type E3 ligase required for cullin neddyl...
    20(a)
    1 → many
    XII(398530-399433)


    ENSEMBL Gene Tree for DCUN1D5 (if available)
    TreeFam Gene Tree for DCUN1D5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCUN1D5 gene
    DCUN1D42  DCUN1D12  DCUN1D32  DCUN1D22  
    4 SIMAP similar genes for DCUN1D5 using alignment to 10 protein entries:     DCNL5_HUMAN (see all proteins):
    DCUN1D4    DCUN1D2    DCUN1D1    DCUN1D3

    DCUN1D5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/770 SNPs in DCUN1D5 are shown (see all 770)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844921621,2
    --102920913(+) GAAAAC/TACAGT 1 -- ds50010--------
    rs1498080551,2
    C--102920960(+) AAATAC/TGCTGT 1 -- ds50010--------
    rs1161001581,2
    C,F--102921013(+) TTCATT/CTTTTC 1 -- ds50011Minor allele frequency- C:0.07WA 118
    rs1457035181,2
    --102921180(+) TTCCCC/TCCAGC 1 -- ds50010--------
    rs781468731,2
    C,F--102921326(+) ATTCCT/CTTAAT 1 -- ds50017Minor allele frequency- C:0.20WA NA CSA EA 366
    rs1895250511,2
    --102921397(+) AATACA/GCAAAA 1 -- ds50010--------
    rs1815288691,2
    --102921491(+) CTGTGG/TATAGT 1 -- ut310--------
    rs1489406421,2
    --102921523(+) AGCAAA/GAACAC 1 -- ut310--------
    rs1126909381,2
    C--102921590(+) CTGTAA/GTATGG 1 -- ut312Minor allele frequency- G:0.04CSA WA 120
    rs1427970261,2
    C--102921918(+) TAACAC/TTGGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DCUN1D5 (102921413 - 102962944 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DCUN1D5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv483025CNV Loss15286789
    dgv1305n71CNV Loss21882294
    nsv468855CNV Loss19166990
    nsv832253CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DCUN1D5 for disorders           About MalaCards
    1 disease from the University of Copenhagen DISEASES database for DCUN1D5:
    Laryngeal squamous cell carcinoma

    DCUN1D5 for disorders           About GeneDecksing


    Export disorders for DCUN1D5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCUN1D5 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with DCUN1D5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PubMed id 15988528)1, 3 Kurz T....Peter M. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Structural conservation of distinctive N-terminal acet ylation-dependent interactions across a family of mammalian NEDD8 ligation enzym es. (PubMed id 23201271)1 Monda J.K....Schulman B.A. (2013)
    5. In vitro biological characterization of DCUN1D5 in DNA damage response. (PubMed id 23098533)1 Guo W....Huang Z.G. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84259 HGNC: 28409 AceView: MGC2714 Ensembl:ENSG00000137692 euGenes: HUgn84259
    ECgene: DCUN1D5 H-InvDB: DCUN1D5

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCUN1D5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for DCUN1D5 gene:
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