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Aliases for DCUN1D5 Gene

Aliases for DCUN1D5 Gene

  • Defective In Cullin Neddylation 1 Domain Containing 5 2 3 5
  • Defective In Cullin Neddylation Protein 1-Like Protein 5 3 4
  • DCUN1 Domain-Containing Protein 5 3 4
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 5 (S. Cerevisiae) 2
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 5 3
  • DCN1-Like Protein 5 3
  • SCCRO5 3

External Ids for DCUN1D5 Gene

Previous GeneCards Identifiers for DCUN1D5 Gene

  • GC11M102439
  • GC11M102932
  • GC11M098850
  • GC11M102923
  • GC11M102924

Summaries for DCUN1D5 Gene

GeneCards Summary for DCUN1D5 Gene

DCUN1D5 (Defective In Cullin Neddylation 1 Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is DCUN1D4.

Additional gene information for DCUN1D5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D5 Gene

Genomics for DCUN1D5 Gene

GeneHancer (GH) Regulatory Elements for DCUN1D5 Gene

Promoters and enhancers for DCUN1D5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I103090 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 521 2.6 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 IRF4 SLC30A9 POLR2B ZNF766 DCUN1D5 DYNC2H1 ENSG00000260966
GH11I103069 Enhancer 0.4 ENCODE 12.3 +21.9 21895 0.9 ZNF316 NFATC1 DYNC2H1 DCUN1D5 ENSG00000260966
GH11I103089 Enhancer 0.3 Ensembl 0.8 +2.9 2914 0.6 PRDM6 DYNC2H1 DCUN1D5 ENSG00000260966
GH11I103055 Enhancer 0.5 ENCODE 0.3 +36.8 36828 0.1 CTCF ZNF654 TRIM22 ZNF143 SMC3 RAD21 ENSG00000260966 MMP13 MMP27 GC11P103046 DCUN1D5
GH11I103056 Enhancer 0.4 ENCODE 0.3 +36.6 36608 0.2 CTCF TRIM22 ENSG00000260966 MMP13 MMP27 GC11P103046 DCUN1D5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCUN1D5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCUN1D5 gene promoter:

Genomic Locations for DCUN1D5 Gene

Genomic Locations for DCUN1D5 Gene
41,532 bases
Minus strand

Genomic View for DCUN1D5 Gene

Genes around DCUN1D5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCUN1D5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCUN1D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D5 Gene

Proteins for DCUN1D5 Gene

  • Protein details for DCUN1D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DCN1-like protein 5
    Protein Accession:
    Secondary Accessions:
    • Q3ZTT2

    Protein attributes for DCUN1D5 Gene

    237 amino acids
    Molecular mass:
    27508 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ76805.1; Type=Frameshift; Positions=222, 232; Evidence={ECO:0000305};

neXtProt entry for DCUN1D5 Gene

Post-translational modifications for DCUN1D5 Gene

  • Ubiquitination at posLast=139139 and posLast=194194

No data available for DME Specific Peptides for DCUN1D5 Gene

Domains & Families for DCUN1D5 Gene

Gene Families for DCUN1D5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCUN1D5 Gene


Suggested Antigen Peptide Sequences for DCUN1D5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCUN1D5: view

No data available for UniProtKB/Swiss-Prot for DCUN1D5 Gene

Function for DCUN1D5 Gene

Phenotypes From GWAS Catalog for DCUN1D5 Gene

Gene Ontology (GO) - Molecular Function for DCUN1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0032182 ubiquitin-like protein binding IBA --
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with DCUN1D5: view
genes like me logo Genes that share phenotypes with DCUN1D5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D5 Gene

Localization for DCUN1D5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCUN1D5 gene
Compartment Confidence
nucleus 3
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCUN1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DCUN1D5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D5 Gene

Pathways & Interactions for DCUN1D5 Gene

SuperPathways for DCUN1D5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045116 protein neddylation IBA --
GO:0051443 positive regulation of ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with DCUN1D5: view

No data available for Pathways by source and SIGNOR curated interactions for DCUN1D5 Gene

Drugs & Compounds for DCUN1D5 Gene

No Compound Related Data Available

Transcripts for DCUN1D5 Gene

Unigene Clusters for DCUN1D5 Gene

DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for DCUN1D5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCUN1D5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCUN1D5 Gene

Protein differential expression in normal tissues from HIPED for DCUN1D5 Gene

This gene is overexpressed in Bone (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCUN1D5 Gene

Protein tissue co-expression partners for DCUN1D5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCUN1D5 Gene:


SOURCE GeneReport for Unigene cluster for DCUN1D5 Gene:


Evidence on tissue expression from TISSUES for DCUN1D5 Gene

  • Lung(4.3)
  • Muscle(4.2)
  • Nervous system(3.6)
  • Skin(2.5)
genes like me logo Genes that share expression patterns with DCUN1D5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCUN1D5 Gene

Orthologs for DCUN1D5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCUN1D5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCUN1D5 33 34
  • 100 (n)
(Monodelphis domestica)
Mammalia DCUN1D5 34
  • 97 (a)
(Bos Taurus)
Mammalia DCUN1D5 33 34
  • 96.89 (n)
(Canis familiaris)
Mammalia DCUN1D5 33 34
  • 95.92 (n)
(Rattus norvegicus)
Mammalia Dcun1d5 33
  • 93.95 (n)
(Mus musculus)
Mammalia Dcun1d5 33 16 34
  • 93.67 (n)
(Ornithorhynchus anatinus)
Mammalia DCUN1D5 34
  • 84 (a)
(Gallus gallus)
Aves DCUN1D5 33 34
  • 88.7 (n)
(Anolis carolinensis)
Reptilia DCUN1D5 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcun1d5 33
  • 80.38 (n)
Str.20280 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.7272 33
(Danio rerio)
Actinopterygii dcun1d5 33 34
  • 75.04 (n)
Dr.28279 33
fruit fly
(Drosophila melanogaster)
Insecta CG6597 34
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2971 34
  • 49 (a)
Species where no ortholog for DCUN1D5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCUN1D5 Gene

Gene Tree for DCUN1D5 (if available)
Gene Tree for DCUN1D5 (if available)

Paralogs for DCUN1D5 Gene

Paralogs for DCUN1D5 Gene

genes like me logo Genes that share paralogs with DCUN1D5: view

Variants for DCUN1D5 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D5 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000096707 -- 103,054,619(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000169709 -- 103,077,490(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000175232 -- 103,059,823(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000321727 -- 103,052,400(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000411967 -- 103,061,297(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D5 Gene

Variant ID Type Subtype PubMed ID
esv3627546 CNV gain 21293372
esv3627547 CNV gain 21293372
nsv1045952 CNV gain 25217958
nsv468855 CNV loss 19166990
nsv556165 CNV loss 21841781
nsv556166 CNV gain 21841781
nsv832253 CNV gain 17160897

Variation tolerance for DCUN1D5 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCUN1D5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D5 Gene

Disorders for DCUN1D5 Gene

Additional Disease Information for DCUN1D5

No disorders were found for DCUN1D5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCUN1D5 Gene

Publications for DCUN1D5 Gene

  1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T … Peter M (Nature 2005) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. (PMID: 26906416) Keuss MJ … Kurz T (Journal of cell science 2016) 3 58

Products for DCUN1D5 Gene

Sources for DCUN1D5 Gene

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