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Aliases for DCUN1D5 Gene

Aliases for DCUN1D5 Gene

  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 5 2 3
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 5 (S. Cerevisiae) 2
  • Defective In Cullin Neddylation Protein 1-Like Protein 5 4
  • DCUN1 Domain-Containing Protein 5 4

External Ids for DCUN1D5 Gene

Previous GeneCards Identifiers for DCUN1D5 Gene

  • GC11M102439
  • GC11M102932
  • GC11M098850
  • GC11M102923
  • GC11M102924

Summaries for DCUN1D5 Gene

GeneCards Summary for DCUN1D5 Gene

DCUN1D5 (DCN1, Defective In Cullin Neddylation 1, Domain Containing 5) is a Protein Coding gene. An important paralog of this gene is DCUN1D1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D5 Gene

Genomics for DCUN1D5 Gene

Regulatory Elements for DCUN1D5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCUN1D5 Gene

Start:
103,050,684 bp from pter
End:
103,092,215 bp from pter
Size:
41,532 bases
Orientation:
Minus strand

Genomic View for DCUN1D5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCUN1D5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D5 Gene

Proteins for DCUN1D5 Gene

  • Protein details for DCUN1D5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTE7-DCNL5_HUMAN
    Recommended name:
    DCN1-like protein 5
    Protein Accession:
    Q9BTE7
    Secondary Accessions:
    • Q3ZTT2

    Protein attributes for DCUN1D5 Gene

    Size:
    237 amino acids
    Molecular mass:
    27508 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ76805.1; Type=Frameshift; Positions=222, 232; Evidence={ECO:0000305};

neXtProt entry for DCUN1D5 Gene

Proteomics data for DCUN1D5 Gene at MOPED

Post-translational modifications for DCUN1D5 Gene

  • Ubiquitination at Lys139 and Lys194
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCUN1D5 Gene

Domains for DCUN1D5 Gene

Protein Domains for DCUN1D5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCUN1D5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BTE7

UniProtKB/Swiss-Prot:

DCNL5_HUMAN :
  • Q9BTE7
Domain:
  • Contains 1 DCUN1 domain.
genes like me logo Genes that share domains with DCUN1D5: view

No data available for Gene Families for DCUN1D5 Gene

Function for DCUN1D5 Gene

Gene Ontology (GO) - Molecular Function for DCUN1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DCUN1D5: view

Phenotypes for DCUN1D5 Gene

genes like me logo Genes that share phenotypes with DCUN1D5: view

Animal Model Products

CRISPR Products

miRNA for DCUN1D5 Gene

miRTarBase miRNAs that target DCUN1D5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCUN1D5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCUN1D5 Gene

Localization for DCUN1D5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCUN1D5 Gene COMPARTMENTS Subcellular localization image for DCUN1D5 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCUN1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with DCUN1D5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D5 Gene

Pathways for DCUN1D5 Gene

SuperPathways for DCUN1D5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DCUN1D5: view

No data available for Pathways by source for DCUN1D5 Gene

Transcripts for DCUN1D5 Gene

Unigene Clusters for DCUN1D5 Gene

DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCUN1D5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for DCUN1D5 Gene

GeneLoc Exon Structure for
DCUN1D5
ECgene alternative splicing isoforms for
DCUN1D5

Expression for DCUN1D5 Gene

mRNA expression in normal human tissues for DCUN1D5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCUN1D5 Gene

SOURCE GeneReport for Unigene cluster for DCUN1D5 Gene Hs.503716

genes like me logo Genes that share expressions with DCUN1D5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCUN1D5 Gene

Orthologs for DCUN1D5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCUN1D5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCUN1D5 35
  • 100 (n)
  • 100 (a)
DCUN1D5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCUN1D5 35
  • 96.89 (n)
  • 98.73 (a)
DCUN1D5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCUN1D5 35
  • 95.92 (n)
  • 98.73 (a)
DCUN1D5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcun1d5 35
  • 93.67 (n)
  • 96.62 (a)
Dcun1d5 16
Dcun1d5 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCUN1D5 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCUN1D5 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcun1d5 35
  • 93.95 (n)
  • 97.05 (a)
chicken
(Gallus gallus)
Aves DCUN1D5 35
  • 88.7 (n)
  • 92.8 (a)
DCUN1D5 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCUN1D5 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7272 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dcun1d5 35
  • 80.38 (n)
  • 89.18 (a)
Str.20280 35
zebrafish
(Danio rerio)
Actinopterygii dcun1d5 35
  • 75.04 (n)
  • 80.09 (a)
dcun1d5 36
  • 74 (a)
OneToOne
Dr.28279 35
fruit fly
(Drosophila melanogaster)
Insecta CG6597 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2971 36
  • 49 (a)
OneToMany
Species with no ortholog for DCUN1D5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCUN1D5 Gene

ENSEMBL:
Gene Tree for DCUN1D5 (if available)
TreeFam:
Gene Tree for DCUN1D5 (if available)

Paralogs for DCUN1D5 Gene

Paralogs for DCUN1D5 Gene

Selected SIMAP similar genes for DCUN1D5 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with DCUN1D5: view

Variants for DCUN1D5 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs12999 -- 103,062,228(+) AAAAA(G/T)GAAAA utr-variant-3-prime
rs508674 -- 103,074,410(-) caaac(A/C)aacaC intron-variant
rs509491 -- 103,079,679(+) cttga(A/G)aggct intron-variant
rs510396 -- 103,086,323(+) atttg(A/G)gttct intron-variant
rs511140 -- 103,065,041(-) AGTTT(G/T)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D5 Gene

Variant ID Type Subtype PubMed ID
nsv832253 CNV Gain 17160897
nsv483025 CNV Loss 15286789
nsv468855 CNV Loss 19166990
dgv1305n71 CNV Loss 21882294

Relevant External Links for DCUN1D5 Gene

HapMap Linkage Disequilibrium report
DCUN1D5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D5 Gene

Disorders for DCUN1D5 Gene

(1) University of Copenhagen DISEASES for DCUN1D5 Gene

genes like me logo Genes that share disorders with DCUN1D5: view

No data available for UniProtKB/Swiss-Prot for DCUN1D5 Gene

Publications for DCUN1D5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T. … Peter M. (Nature 2005) 2 3
  4. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DCUN1D5 Gene

Sources for DCUN1D5 Gene

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