Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCUN1D4 Gene

protein-coding   GIFtS: 51
GCID: GC04P052709

DCN1, Defective In Cullin Neddylation 1, Domain Containing...

(Previous names: DCN1, defective in cullin neddylation 1, domain containing...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DCN1, Defective In Cullin Neddylation 1, Domain Containing 41 2
Defective In Cullin Neddylation Protein 1-Like Protein 42 3
DCUN1 Domain-Containing Protein 42 3
KIAA02763 5
DCN1, Defective In Cullin Neddylation 1, Domain Containing 4 (S.
Cerevisiae)1
DCN1-Like Protein 42

External Ids:    HGNC: 289981   Entrez Gene: 231422   Ensembl: ENSG000001091847   OMIM: 6129775   UniProtKB: Q925643   

Export aliases for DCUN1D4 gene to outside databases

Previous GC identifers: GC04P052551 GC04P052404 GC04P048650


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DCUN1D4 Gene: 
DCUN1D4 (DCN1, defective in cullin neddylation 1, domain containing 4) is a protein-coding gene. Diseases associated with DCUN1D4 include pancreatic cancer, and pancreatitis. GO annotations related to this gene include molecular_function. An important paralog of this gene is DCUN1D5.

Gene Wiki entry for DCUN1D4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022853.15  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCUN1D4 gene promoter:
         TBP   AhR   ATF-2   HSF1 (long)   Arnt   GATA-2   RORalpha1   Ik-2   HSF1short   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCUN1D4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCUN1D4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q11

DCUN1D4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCUN1D4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P052709:  view genomic region     (about GC identifiers)

Start:
52,709,166 bp from pter      End:
52,783,003 bp from pter
Size:
73,838 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCNL4_HUMAN, Q92564 (See protein sequence)
Recommended Name: DCN1-like protein 4  
Size: 292 amino acids; 34068 Da
Sequence caution: Sequence=BAA13405.1; Type=Erroneous initiation; Sequence=CAD97912.1; Type=Erroneous initiation;
Secondary accessions: Q7Z3F3 Q7Z6B8
Alternative splicing: 2 isoforms:  Q92564-1   Q92564-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCUN1D4: NX_Q92564

Explore proteomics data for DCUN1D4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92564

  • DCUN1D4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCUN1D4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001035492.1  NP_055930.2  

    ENSEMBL proteins: 
     ENSP00000425644   ENSP00000334625   ENSP00000370850   ENSP00000421127   ENSP00000425792  
     ENSP00000423808   ENSP00000424476   ENSP00000421699   ENSP00000426982   ENSP00000422711  
     ENSP00000426048   ENSP00000423794   ENSP00000389900   ENSP00000370846  

    Human Recombinant Protein Products for DCUN1D4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DCUN1D4
    OriGene Protein Over-expression Lysate for DCUN1D4
    OriGene MassSpec for DCUN1D4 
    OriGene Custom Protein Services for DCUN1D4
    GenScript Custom Purified and Recombinant Proteins Services for DCUN1D4
    Novus Biologicals DCUN1D4 Proteins
    Novus Biologicals DCUN1D4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCUN1D4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus ----

    DCUN1D4 for ontologies           About GeneDecksing



    DCUN1D4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DCUN1D4
    GenScript Custom Superior Antibodies Services for DCUN1D4
    Novus Biologicals DCUN1D4 Antibodies
    Abcam antibodies for DCUN1D4
    Cloud-Clone Corp. Antibodies for DCUN1D4 
    ThermoFisher Antibody for DCUN1D4
    LSBio Antibodies in human, mouse, rat for DCUN1D4 

    Assay Products for DCUN1D4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DCUN1D4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DCUN1D4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DCUN1D4 
    Cloud-Clone Corp. CLIAs for DCUN1D4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR005176 PONY_dom
     IPR014764 DCN-prot

    Graphical View of Domain Structure for InterPro Entry Q92564

    ProtoNet protein and cluster: Q92564

    UniProtKB/Swiss-Prot: DCNL4_HUMAN, Q92564
    Similarity: Contains 1 DCUN1 domain


    DCUN1D4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    DCUN1D4 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DCUN1D4:
     Increased gamma-H2AX phosphory  Increased number of cells in m  Metaphase cells 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DCUN1D4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DCUN1D4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCUN1D4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCUN1D4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCUN1D4
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate DCUN1D4 (see all 100):
    hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-4274 hsa-miR-200b hsa-miR-3148 hsa-miR-130b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidDCUN1D4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DCUN1D4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCUN1D4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DCUN1D4
    Sirion Biotech Customized adenovirus for overexpression of DCUN1D4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DCUN1D4 (see all 16)
    OriGene ORF clones in mouse, rat for DCUN1D4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DCUN1D4 (NM_015115)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCUN1D4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D4
    Sirion Biotech Customized lentivirus for stable overexpression of DCUN1D4 
                         Customized lentivirus expression plasmids for stable overexpression of DCUN1D4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DCUN1D4
    Search LifeMap BioReagents cell lines for DCUN1D4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCUN1D4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for DCUN1D4 (Q925643 ENSP000003346254) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    UBE2MENSP000002530234STRING: ENSP00000253023
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    DCUN1D4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCUN1D4 (DCNL4)

    Search CenterWatch for drugs/clinical trials and news about DCUN1D4 / DCNL4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCUN1D4 gene (2 alternative transcripts): 
    NM_001040402.1  NM_015115.2  

    Unigene Cluster for DCUN1D4:

    DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae)
    Hs.605388  [show with all ESTs]
    Unigene Representative Sequence: NM_001040402
    18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000509376 ENST00000511675 ENST00000334635(uc003gze.3 uc011bzn.2 uc011bzo.2)
    ENST00000381441(uc003gzf.3) ENST00000506673 ENST00000504113 ENST00000502930
    ENST00000513800 ENST00000507741 ENST00000477560(uc003gzg.3 uc003gzh.3)
    ENST00000509068 ENST00000505403 ENST00000504661 ENST00000504923 ENST00000510587
    ENST00000507659 ENST00000505634 ENST00000510808
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCUN1D4
    8/100 QIAGEN miScript miRNA Assays for microRNAs that regulate DCUN1D4 (see all 100):
    hsa-miR-300 hsa-miR-15a hsa-miR-128 hsa-miR-4274 hsa-miR-200b hsa-miR-3148 hsa-miR-130b hsa-miR-374b*
    SwitchGear 3'UTR luciferase reporter plasmidDCUN1D4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DCUN1D4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCUN1D4
    Clone
    Products:
         
    OriGene clones in human, mouse for DCUN1D4 (see all 16)
    OriGene ORF clones in mouse, rat for DCUN1D4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DCUN1D4 (NM_015115)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCUN1D4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D4
    Sirion Biotech Customized lentivirus for stable overexpression of DCUN1D4 
                         Customized lentivirus expression plasmids for stable overexpression of DCUN1D4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DCUN1D4
    OriGene qSTAR qPCR primer pairs in human, mouse for DCUN1D4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCUN1D4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCUN1D4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCUN1D4

    Additional mRNA sequence: 

    AK027051.1 AK124346.1 AK294894.1 AK294896.1 BC015240.1 BC041702.1 BC053897.1 BX537944.1 
    BX640660.1 D87466.1 

    16 DOTS entries:

    DT.100726691  DT.445259  DT.91658198  DT.86854420  DT.101984033  DT.95317671  DT.216963  DT.91917580 
    DT.92011120  DT.97789117  DT.100709206  DT.100721365  DT.100821535  DT.121232849  DT.121232856  DT.97765242 

    24/209 AceView cDNA sequences (see all 209):

    BF061427 AI419011 BX477958 AI433882 BU195694 CB268080 AI032291 BC015240 
    AL047872 AL700442 AW195432 BM699002 BM979576 AI352435 CB118671 BF110371 
    AA854727 CD300375 AA410430 AW131406 BQ675161 CD677232 AW263041 AI625850 

    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D4 (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                                            -     -                       -           -     -     -                                   -     -     -     -   
    SP2:                                            -     -                       -           -     -     -                                   -     -     -     -   
    SP3:                                                                                      -     -     -                                   -           -     -   
    SP4:                                            -     -                       -           -                                                                     
    SP5:                                                                                                                                      -     -     -     -   

    ExUns: 17b · 17c ^ 18 ^ 19a · 19b · 19c · 19d · 19e ^ 20
    SP1:                                                      
    SP2:  -     -                                             
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for DCUN1D4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCUN1D4 expression in normal human tissues (normalized intensities)      DCUN1D4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAAAGT
    DCUN1D4 Expression
    About this image


    DCUN1D4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             bone marrow cd34+   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             posterior singulate   
     
     Eye (Sensory Organs)
             Retina
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   
     
     Testis (Reproductive System)
             sperm   

    See DCUN1D4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCUN1D4

    SOURCE GeneReport for Unigene cluster: Hs.605388
        SABiosciences Custom PCR Arrays for DCUN1D4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DCUN1D4
    OriGene qSTAR qPCR primer pairs in human, mouse for DCUN1D4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCUN1D4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCUN1D4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCUN1D4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DCUN1D4 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcun1d41 , 5 DCN1, defective in cullin neddylation 1, domain containing more1, 5 92.01(n)1
    96.58(a)1
      5 (38.85 cM)5
    1007371  NM_178896.51  NP_849227.11 
     734810025 
    chicken
    (Gallus gallus)
    Aves DCUN1D41 DCN1, defective in cullin neddylation 1, domain containing more 87.67(n)
    94.18(a)
      422762  XM_420715.2  XP_420715.2 
    lizard
    (Anolis carolinensis)
    Reptilia DCUN1D46
    DCN1, defective in cullin neddylation 1, domain co...
    91(a)
    1 ↔ 1
    GL343293.1(1166318-1202827)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.165052 Transcribed sequence with moderate similarity to protein more 78.19(n)    CF550505.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65971 CG6597 59.11(n)
    64(a)
      40231  NM_001202210.2  NP_001189139.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCN16
    Scaffold-type E3 ligase required for cullin neddyl...
    20(a)
    1 → many
    XII(398530-399433)


    ENSEMBL Gene Tree for DCUN1D4 (if available)
    TreeFam Gene Tree for DCUN1D4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCUN1D4 gene
    DCUN1D52  DCUN1D12  DCUN1D32  DCUN1D22  
    5 SIMAP similar genes for DCUN1D4 using alignment to 12 protein entries:     DCNL4_HUMAN (see all proteins):
    RBMS2    DCUN1D5    DCUN1D2    DCUN1D1    SNRPF

    DCUN1D4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1185 SNPs in DCUN1D4 are shown (see all 1185)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822415911,2
    --52707356(+) CCTTTC/TCTGTG 2 -- us2k10--------
    rs1155937341,2
    F--52707367(+) CAAAAT/CAACAT 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1438730831,2
    C--52707371(+) ATAAC-/ATTGTGT 2 -- us2k10--------
    rs1468714861,2
    --52707387(+) TCTTTC/GAAGTA 2 -- us2k10--------
    rs1407413261,2
    C--52707583(+) CCCAAA/CAAGCA 2 -- us2k10--------
    rs1857848401,2
    --52707781(+) AATGAC/TAAAAA 2 -- us2k10--------
    rs1143357921,2
    F--52707845(+) TAAGAT/GGGAGG 2 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1890383321,2
    --52707851(+) GGAGGA/GAGCAT 2 -- us2k10--------
    rs1809107491,2
    --52708008(+) CCGTGC/TGTTCT 2 -- us2k10--------
    rs1855248641,2
    --52708128(+) GATGAA/GGGTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DCUN1D4 (52709166 - 52783003 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DCUN1D4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428444CNV Gain18775914
    dgv1620e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DCUN1D4
    DNA2.0 Custom Variant and Variant Library Synthesis for DCUN1D4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612977    OMIM disorders: --

    2 diseases for DCUN1D4:    About MalaCards
    pancreatic cancer    pancreatitis


    DCUN1D4 for disorders           About GeneDecksing


    Export disorders for DCUN1D4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCUN1D4 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with DCUN1D4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PubMed id 15988528)1, 3 Kurz T....Peter M. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    4. Structural conservation of distinctive N-terminal acet ylation-dependent interactions across a family of mammalian NEDD8 ligation enzym es. (PubMed id 23201271)1 Monda J.K....Schulman B.A. (2013)
    5. N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. (PubMed id 21940857)1 Scott D.C.... Schulman B.A. (2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    8. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. (PubMed id 18654987)1 Thalappilly S....Dusetti N.J. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23142 HGNC: 28998 AceView: KIAA0276 Ensembl:ENSG00000109184 euGenes: HUgn23142
    ECgene: DCUN1D4 H-InvDB: DCUN1D4

    (According to HUGE)
    About This Section
    HUGE: KIAA0276

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCUN1D4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCUN1D4 gene:
    Search GeneIP for patents involving DCUN1D4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DCUN1D4  
     OriGene qPCR primer pairs and template standards for DCUN1D4   OriGene Protein Over-expression Lysate for DCUN1D4  
     OriGene MassSpec something-or-other for DCUN1D4   OriGene clones in human, mouse for DCUN1D4  
     OriGene qSTAR qPCR primer pairs in human, mouse for DCUN1D4   OriGene Purified Protein for DCUN1D4  
     OriGene ORF clones in mouse, rat for DCUN1D4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DCUN1D4   OriGene Custom Protein Services for DCUN1D4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCUN1D4
     QIAGEN SeqTarget long-range PCR primers for resequencing DCUN1D4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCUN1D4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCUN1D4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCUN1D4
     GenScript Custom Purified and Recombinant Proteins Services for DCUN1D4 GenScript cDNA clones with any tag delivered in your preferred vector for DCUN1D4
     GenScript Custom Assay Services for DCUN1D4 GenScript Custom Superior Antibodies Services for DCUN1D4
     GenScript Custom overexpressing Cell Line Services for DCUN1D4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DCUN1D4 promoter
     Search Chromatin IP Primers for DCUN1D4
     RT2 qPCR Primer Assay in human, mouse, rat DCUN1D4
     Search GNC Networks for DCUN1D4
     SABiosciences Custom PCR Arrays for DCUN1D4
     Search Tocris compounds for DCUN1D4 (DCNL4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DCUN1D4 antibodies
     DCUN1D4 proteins
     DCUN1D4 lysates
     Antibodies for DCUN1D4
     See all of Abcam's Antibodies, Kits and Proteins for DCUN1D4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DCUN1D4
     Antibodies for DCUN1D4
     ELISAs for DCUN1D4
     CLIAs for DCUN1D4
     Search LifeMap BioReagents cell lines for DCUN1D4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D4
     SwitchGear 3'UTR luciferase reporter plasmids for DCUN1D4
     SwitchGear Promoter luciferase reporter plasmids for DCUN1D4
     ThermoFisher Antibody for DCUN1D4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DCUN1D4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DCUN1D4
    Customized:
     lentivirus for stable overexpression of DCUN1D4
     lentivirus expression plasmids for stable overexpression of DCUN1D4
     adenovirus for overexpression of DCUN1D4
     LSBio Antibodies in human, mouse, rat for DCUN1D4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DCUN1D4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4