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Aliases for DCUN1D4 Gene

Aliases for DCUN1D4 Gene

  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 4 2 3
  • KIAA0276 4 6
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 4 (S. Cerevisiae) 2
  • Defective In Cullin Neddylation Protein 1-Like Protein 4 4
  • DCUN1 Domain-Containing Protein 4 4

External Ids for DCUN1D4 Gene

Previous GeneCards Identifiers for DCUN1D4 Gene

  • GC04P052551
  • GC04P052404
  • GC04P052709
  • GC04P048650

Summaries for DCUN1D4 Gene

GeneCards Summary for DCUN1D4 Gene

DCUN1D4 (DCN1, Defective In Cullin Neddylation 1, Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is DCUN1D1.

Gene Wiki entry for DCUN1D4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D4 Gene

Genomics for DCUN1D4 Gene

Regulatory Elements for DCUN1D4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCUN1D4 Gene

Start:
51,833,844 bp from pter
End:
51,916,837 bp from pter
Size:
82,994 bases
Orientation:
Plus strand

Genomic View for DCUN1D4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCUN1D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D4 Gene

Proteins for DCUN1D4 Gene

  • Protein details for DCUN1D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92564-DCNL4_HUMAN
    Recommended name:
    DCN1-like protein 4
    Protein Accession:
    Q92564
    Secondary Accessions:
    • B4DH25
    • Q7Z3F3
    • Q7Z6B8

    Protein attributes for DCUN1D4 Gene

    Size:
    292 amino acids
    Molecular mass:
    34068 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13405.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97912.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCUN1D4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCUN1D4 Gene

Proteomics data for DCUN1D4 Gene at MOPED

Post-translational modifications for DCUN1D4 Gene

  • Ubiquitination at Lys194
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DCUN1D4

No data available for DME Specific Peptides for DCUN1D4 Gene

Domains for DCUN1D4 Gene

Protein Domains for DCUN1D4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q92564

UniProtKB/Swiss-Prot:

DCNL4_HUMAN :
  • Q92564
Domain:
  • Contains 1 DCUN1 domain.
genes like me logo Genes that share domains with DCUN1D4: view

No data available for Gene Families for DCUN1D4 Gene

Function for DCUN1D4 Gene

Gene Ontology (GO) - Molecular Function for DCUN1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21911577
genes like me logo Genes that share ontologies with DCUN1D4: view
genes like me logo Genes that share phenotypes with DCUN1D4: view

Animal Model Products

CRISPR Products

miRNA for DCUN1D4 Gene

miRTarBase miRNAs that target DCUN1D4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCUN1D4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCUN1D4 Gene

Localization for DCUN1D4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCUN1D4 Gene COMPARTMENTS Subcellular localization image for DCUN1D4 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCUN1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with DCUN1D4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D4 Gene

Pathways for DCUN1D4 Gene

SuperPathways for DCUN1D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DCUN1D4: view

No data available for Pathways by source for DCUN1D4 Gene

Transcripts for DCUN1D4 Gene

Unigene Clusters for DCUN1D4 Gene

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCUN1D4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11: - - - - - - -
SP12: - - -
SP13:
SP14: - - - - - -
SP15: -
SP16: - - - -
SP17:

ExUns: 17b · 17c ^ 18 ^ 19a · 19b · 19c · 19d · 19e ^ 20
SP1:
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DCUN1D4 Gene

GeneLoc Exon Structure for
DCUN1D4
ECgene alternative splicing isoforms for
DCUN1D4

Expression for DCUN1D4 Gene

mRNA expression in normal human tissues for DCUN1D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DCUN1D4 Gene

This gene is overexpressed in Bone (48.2) and Adipocyte (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCUN1D4 Gene

SOURCE GeneReport for Unigene cluster for DCUN1D4 Gene Hs.605388

genes like me logo Genes that share expressions with DCUN1D4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for DCUN1D4 Gene

Orthologs for DCUN1D4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCUN1D4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DCUN1D4 35
  • 88.09 (n)
  • 91.22 (a)
DCUN1D4 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcun1d4 35
  • 91.7 (n)
  • 95.79 (a)
Dcun1d4 16
Dcun1d4 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcun1d4 35
  • 91.11 (n)
  • 96.14 (a)
cow
(Bos Taurus)
Mammalia DCUN1D4 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCUN1D4 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCUN1D4 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCUN1D4 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCUN1D4 35
  • 87.02 (n)
  • 93.33 (a)
DCUN1D4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCUN1D4 36
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dcun1d4 35
  • 74.79 (n)
  • 85.45 (a)
Dr.16505 35
dcun1d4 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002513 35
  • 60.63 (n)
  • 67.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6597 35
  • 59.11 (n)
  • 64 (a)
CG6597 36
  • 59 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2971 36
  • 50 (a)
OneToMany
Species with no ortholog for DCUN1D4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCUN1D4 Gene

ENSEMBL:
Gene Tree for DCUN1D4 (if available)
TreeFam:
Gene Tree for DCUN1D4 (if available)

Paralogs for DCUN1D4 Gene

Paralogs for DCUN1D4 Gene

genes like me logo Genes that share paralogs with DCUN1D4: view

Variants for DCUN1D4 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs13531 -- 51,913,882(+) AAAAG(C/G)TTCAC utr-variant-3-prime, nc-transcript-variant
rs15919 -- 51,916,866(-) AGCCA(A/G)AAGAG downstream-variant-500B
rs1875917 -- 51,895,655(-) GCCCC(C/T)GCCCC intron-variant
rs1875918 -- 51,895,649(-) GCCCC(C/T)TCACT intron-variant
rs1875919 -- 51,855,850(+) CATGG(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D4 Gene

Variant ID Type Subtype PubMed ID
dgv1620e1 CNV Complex 17122850
nsv428444 CNV Gain 18775914

Relevant External Links for DCUN1D4 Gene

HapMap Linkage Disequilibrium report
DCUN1D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D4 Gene

Disorders for DCUN1D4 Gene

No disorders were found for DCUN1D4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DCUN1D4 Gene

Publications for DCUN1D4 Gene

  1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T. … Peter M. (Nature 2005) 2 3
  2. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3

Products for DCUN1D4 Gene

Sources for DCUN1D4 Gene

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