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Aliases for DCUN1D4 Gene

Aliases for DCUN1D4 Gene

  • Defective In Cullin Neddylation 1 Domain Containing 4 2 3 5
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 4 (S. Cerevisiae) 2
  • Defective In Cullin Neddylation Protein 1-Like Protein 4 4
  • DCUN1 Domain-Containing Protein 4 4
  • KIAA0276 4

External Ids for DCUN1D4 Gene

Previous GeneCards Identifiers for DCUN1D4 Gene

  • GC04P052551
  • GC04P052404
  • GC04P052709
  • GC04P048650

Summaries for DCUN1D4 Gene

GeneCards Summary for DCUN1D4 Gene

DCUN1D4 (Defective In Cullin Neddylation 1 Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is DCUN1D5.

Gene Wiki entry for DCUN1D4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D4 Gene

Genomics for DCUN1D4 Gene

Regulatory Elements for DCUN1D4 Gene

Enhancers for DCUN1D4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DCUN1D4 on UCSC Golden Path with GeneCards custom track

Promoters for DCUN1D4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DCUN1D4 Gene

Chromosome:
4
Start:
51,843,000 bp from pter
End:
51,916,837 bp from pter
Size:
73,838 bases
Orientation:
Plus strand

Genomic View for DCUN1D4 Gene

Genes around DCUN1D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCUN1D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCUN1D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D4 Gene

Proteins for DCUN1D4 Gene

  • Protein details for DCUN1D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92564-DCNL4_HUMAN
    Recommended name:
    DCN1-like protein 4
    Protein Accession:
    Q92564
    Secondary Accessions:
    • B4DH25
    • Q7Z3F3
    • Q7Z6B8

    Protein attributes for DCUN1D4 Gene

    Size:
    292 amino acids
    Molecular mass:
    34068 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13405.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD97912.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCUN1D4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCUN1D4 Gene

Post-translational modifications for DCUN1D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DCUN1D4 Gene

Domains & Families for DCUN1D4 Gene

Protein Domains for DCUN1D4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q92564

UniProtKB/Swiss-Prot:

DCNL4_HUMAN :
  • Contains 1 DCUN1 domain.
Domain:
  • Contains 1 DCUN1 domain.
genes like me logo Genes that share domains with DCUN1D4: view

No data available for Gene Families for DCUN1D4 Gene

Function for DCUN1D4 Gene

Gene Ontology (GO) - Molecular Function for DCUN1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21911577
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0032182 ubiquitin-like protein binding IBA --
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with DCUN1D4: view
genes like me logo Genes that share phenotypes with DCUN1D4: view

Animal Model Products

CRISPR Products

miRNA for DCUN1D4 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D4 Gene

Localization for DCUN1D4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCUN1D4 Gene COMPARTMENTS Subcellular localization image for DCUN1D4 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCUN1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with DCUN1D4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D4 Gene

Pathways & Interactions for DCUN1D4 Gene

SuperPathways for DCUN1D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0045116 protein neddylation IBA --
GO:0051443 positive regulation of ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with DCUN1D4: view

No data available for Pathways by source and SIGNOR curated interactions for DCUN1D4 Gene

Drugs & Compounds for DCUN1D4 Gene

No Compound Related Data Available

Transcripts for DCUN1D4 Gene

Unigene Clusters for DCUN1D4 Gene

DCN1, defective in cullin neddylation 1, domain containing 4 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - -
SP7: - - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - -
SP10: - - - - - - -
SP11: - - - - - - -
SP12: - - -
SP13:
SP14: - - - - - -
SP15: -
SP16: - - - -
SP17:

ExUns: 17b · 17c ^ 18 ^ 19a · 19b · 19c · 19d · 19e ^ 20
SP1:
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DCUN1D4 Gene

GeneLoc Exon Structure for
DCUN1D4
ECgene alternative splicing isoforms for
DCUN1D4

Expression for DCUN1D4 Gene

mRNA expression in normal human tissues for DCUN1D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCUN1D4 Gene

This gene is overexpressed in Bone (48.2) and Adipocyte (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCUN1D4 Gene



NURSA nuclear receptor signaling pathways regulating expression of DCUN1D4 Gene:

DCUN1D4

SOURCE GeneReport for Unigene cluster for DCUN1D4 Gene:

Hs.605388
genes like me logo Genes that share expression patterns with DCUN1D4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DCUN1D4 Gene

Orthologs for DCUN1D4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCUN1D4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DCUN1D4 34
  • 88.09 (n)
  • 91.22 (a)
DCUN1D4 35
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcun1d4 34
  • 91.7 (n)
  • 95.79 (a)
Dcun1d4 16
Dcun1d4 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcun1d4 34
  • 91.11 (n)
  • 96.14 (a)
cow
(Bos Taurus)
Mammalia DCUN1D4 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCUN1D4 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCUN1D4 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCUN1D4 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCUN1D4 34
  • 87.02 (n)
  • 93.33 (a)
DCUN1D4 35
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCUN1D4 35
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dcun1d4 34
  • 74.79 (n)
  • 85.45 (a)
Dr.16505 34
dcun1d4 35
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002513 34
  • 60.63 (n)
  • 67.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6597 34
  • 59.11 (n)
  • 64 (a)
CG6597 35
  • 59 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 35
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2971 35
  • 50 (a)
OneToMany
Species where no ortholog for DCUN1D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCUN1D4 Gene

ENSEMBL:
Gene Tree for DCUN1D4 (if available)
TreeFam:
Gene Tree for DCUN1D4 (if available)

Paralogs for DCUN1D4 Gene

Paralogs for DCUN1D4 Gene

genes like me logo Genes that share paralogs with DCUN1D4: view

Variants for DCUN1D4 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs13531 -- 51,913,882(+) AAAAG(C/G)TTCAC nc-transcript-variant, utr-variant-3-prime
rs15919 -- 51,916,866(-) AGCCA(A/G)AAGAG downstream-variant-500B
rs1875917 -- 51,895,655(-) GCCCC(C/T)GCCCC intron-variant
rs1875918 -- 51,895,649(-) GCCCC(C/T)TCACT intron-variant
rs1875919 -- 51,855,850(+) CATGG(A/G)AAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D4 Gene

Variant ID Type Subtype PubMed ID
esv2759252 CNV gain 17122850
nsv1012793 CNV gain 25217958
nsv1073759 CNV deletion 25765185
nsv428444 CNV gain 18775914

Variation tolerance for DCUN1D4 Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCUN1D4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCUN1D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D4 Gene

Disorders for DCUN1D4 Gene

Relevant External Links for DCUN1D4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCUN1D4

No disorders were found for DCUN1D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCUN1D4 Gene

Publications for DCUN1D4 Gene

  1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T. … Peter M. (Nature 2005) 2 3 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 65
  4. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. (PMID: 26906416) Keuss M.J. … Kurz T. (J. Cell. Sci. 2016) 3 65
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65

Products for DCUN1D4 Gene

Sources for DCUN1D4 Gene

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