DCUN1D3 Gene
protein-coding GIFtS: 41
GCID: GC16M020869
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DCN1, defective in cullin neddylation 1, domain containing...
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Aliases
for DCUN1D3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DCN1, Defective In Cullin Neddylation 1, Domain Containing 3 (S.Cerevisiae)1 2 | | FLJ417251 | | Defective In Cullin Neddylation Protein 1-Like Protein 32 3 | | MGC489721 | | DCUN1 Domain-Containing Protein 32 3 | | 44M2.42 | | DKFZp686O02901 | | DCN1-Like Protein 32 |
Export aliases for DCUN1D3 gene to outside databasesPrevious GC identifers: GC16M020776 GC16M019404 |
Summaries
for DCUN1D3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DCUN1D3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DCUN1D3 gene promoter:
E2F-3a E2F-4 E2F-5 AP-1 E2F-2 RORalpha1 E2F-1 E2F STAT3 SEF-1 (1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCUN1D3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.3 Ensembl cytogenetic band: 16p12.3 HGNC cytogenetic band: 16p12.3DCUN1D3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M020869: view genomic region
(about GC identifiers)
Start:
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20,869,396 bp from pter |
End:
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20,911,706 bp from pter |
Size:
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42,311 bases |
Orientation:
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minus strand |
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Proteins
for DCUN1D3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCNL3_HUMAN, Q8IWE4 (See
protein sequence)Recommended Name: DCN1-like protein 3 Size: 304 amino acids; 34291 Da
1 PDB 3D structure from  and Proteopedia  for DCUN1D3:4GBA (3D)
Secondary accessions: B3KVY4Explore the universe of human proteins at neXtProt for DCUN1D3: NX_Q8IWE4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWE4
DCUN1D3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775746.1
ENSEMBL proteins: ENSP00000319482 ENSP00000454762
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0048471 | perinuclear region of cytoplasm |
IDA | 18823379 |
DCUN1D3 for ontologies About GeneDecksing
DCUN1D3 Antibody Products:
Assay Products for DCUN1D3: |
Protein
Domains /
Families
for DCUN1D3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCUN1D3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IWE4ProtoNet protein and cluster: Q8IWE4 UniProtKB/Swiss-Prot: DCNL3_HUMAN, Q8IWE4Similarity: Contains 1 DCUN1 domain |
Function
for DCUN1D3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for DCUN1D3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D3 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
DCUN1D3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DCUN1D3:
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Pathways & Interactions
for DCUN1D3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCUN1D3
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for DCUN1D3 (ENSP000003194824) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
DCUN1D3 for ontologies About GeneDecksing
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Drugs & Compounds
for DCUN1D3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCUN1D3
Search CenterWatch for drugs/clinical trials and news about DCUN1D3 / DCNL3
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Transcripts
for DCUN1D3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCUN1D3 gene: NM_173475.2 Unigene Cluster for DCUN1D3: DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae) Hs.101007 [show with all ESTs]Unigene Representative Sequence: BC0404422 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000324344(uc002dhz.3) ENST00000563934
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCUN1D3 (NM_173475) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCUN1D3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D3 |
Additional cDNA sequence: AY364247.1 BC040442.1 BX648998.1 6 DOTS entries: DT.307418 DT.100728255 DT.120704372 DT.100738741 DT.95206956 DT.120704358 24/198 AceView cDNA sequences (see all 198): AI950985 AA971261 D25640 BE467706 AI624936 AI018327 N75262 AA281408 AI424831 BX280488 AA234468 AW780059 AA301276 AK127391 AI282687 AW613517 AV727791 CA447047 BF435642 CA866766 AL704082 AA917668 AW341521 AL047528
GeneLoc Exon Structure
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Expression
for DCUN1D3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCUN1D3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DCUN1D3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCUN1D3
SOURCE GeneReport for Unigene cluster: Hs.101007
SABiosciences Custom PCR Arrays for DCUN1D3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCUN1D3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCUN1D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCUN1D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCUN1D3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D3 |
Orthologs
for DCUN1D3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for DCUN1D3 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for DCUN1D3 (if available)
TreeFam Gene Tree for DCUN1D3 (if available) |
Paralogs
for DCUN1D3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DCUN1D3 gene
- DCUN1D42 DCUN1D52 DCUN1D12 DCUN1D22
3 SIMAP similar genes for DCUN1D3 using alignment to 1 protein entry: DCNL3_HUMAN:DCUN1D1 DCUN1D2 DCUN1D5
DCUN1D3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DCUN1D3
PGOHUM00000235476
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Genomic Variants
for DCUN1D3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCUN1D3 (20869396 - 20911706 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DCUN1D3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCUN1D3 |
|
Disorders
/ Diseases
for DCUN1D3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DCUN1D3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCUN1D3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DCUN1D3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PubMed id 15988528)1, 3 Kurz T....Peter M. (2005)
- DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth. (PubMed id 18823379)1, 9 Ma T....Qiu X. (2008)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- NovelFam3000 -- uncharacterized human protein domains conserved across model organisms. (PubMed id 16533400)2 Kemmer D.... Wasserman W.W. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1 Loftus B.J.... Adams M.D. (1999)
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External Searches for DCUN1D3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DCUN1D3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCUN1D3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCUN1D3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCUN1D3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DCUN1D3 gene:
Search GeneIP for patents involving DCUN1D3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCUN1D3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DCUN1D3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCUN1D3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCUN1D3 | | | OriGene Protein Over-expression Lysate for DCUN1D3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DCUN1D3 | | OriGene 3'-UTR Clone for DCUN1D3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCUN1D3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DCUN1D3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | DCUN1D3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D3 |
|  |  |  | | | | ThermoFisher Antibodies for DCUN1D3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D3 |
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