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Aliases for DCUN1D3 Gene

Aliases for DCUN1D3 Gene

  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 3 2 3
  • Defective In Cullin Neddylation Protein 1-Like Protein 3 3 4
  • Squamous Cell Carcinoma-Related Oncogene 3 3 4
  • DCUN1 Domain-Containing Protein 3 3 4
  • SCCRO3 3 4
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 3 (S. Cerevisiae) 2
  • 44M2.4 3

External Ids for DCUN1D3 Gene

Previous GeneCards Identifiers for DCUN1D3 Gene

  • GC16M020776
  • GC16M019404

Summaries for DCUN1D3 Gene

GeneCards Summary for DCUN1D3 Gene

DCUN1D3 (DCN1, Defective In Cullin Neddylation 1, Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is DCUN1D1.

UniProtKB/Swiss-Prot for DCUN1D3 Gene

  • Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D3 Gene

Genomics for DCUN1D3 Gene

Regulatory Elements for DCUN1D3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCUN1D3 Gene

Chromosome:
16
Start:
20,854,925 bp from pter
End:
20,900,384 bp from pter
Size:
45,460 bases
Orientation:
Minus strand

Genomic View for DCUN1D3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for DCUN1D3 Gene

Proteins for DCUN1D3 Gene

  • Protein details for DCUN1D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWE4-DCNL3_HUMAN
    Recommended name:
    DCN1-like protein 3
    Protein Accession:
    Q8IWE4
    Secondary Accessions:
    • B3KVY4

    Protein attributes for DCUN1D3 Gene

    Size:
    304 amino acids
    Molecular mass:
    34291 Da
    Quaternary structure:
    • Interacts with CAND1, CUL1, CUL3 and RBX1 through the DCUN1 domain. In vitro, the DCUN1/PONY domain binds UBE2F and, with lower affinity, UBE2M (PubMed:23201271). This interaction is not detected in vivo with full length protein (PubMed:25349211).

    Three dimensional structures from OCA and Proteopedia for DCUN1D3 Gene

neXtProt entry for DCUN1D3 Gene

Proteomics data for DCUN1D3 Gene at MOPED

Post-translational modifications for DCUN1D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCUN1D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCUN1D3 Gene

Domains & Families for DCUN1D3 Gene

Protein Domains for DCUN1D3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCUN1D3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWE4

UniProtKB/Swiss-Prot:

DCNL3_HUMAN :
  • The DCUN1 domain, also known as PONY domain, mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme. This domain is also involved in CAND1-, CUL1-, CUL3- and RBX1-binding.
Domain:
  • The DCUN1 domain, also known as PONY domain, mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme. This domain is also involved in CAND1-, CUL1-, CUL3- and RBX1-binding.
  • Contains 1 DCUN1 domain.
genes like me logo Genes that share domains with DCUN1D3: view

No data available for Gene Families for DCUN1D3 Gene

Function for DCUN1D3 Gene

Molecular function for DCUN1D3 Gene

UniProtKB/Swiss-Prot Function:
Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

Gene Ontology (GO) - Molecular Function for DCUN1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0032182 ubiquitin-like protein binding IBA --
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with DCUN1D3: view

Phenotypes for DCUN1D3 Gene

genes like me logo Genes that share phenotypes with DCUN1D3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCUN1D3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D3 Gene

Localization for DCUN1D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D3 Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCUN1D3 Gene COMPARTMENTS Subcellular localization image for DCUN1D3 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DCUN1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005886 plasma membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 18823379
genes like me logo Genes that share ontologies with DCUN1D3: view

Pathways & Interactions for DCUN1D3 Gene

SuperPathways for DCUN1D3 Gene

No Data Available

Interacting Proteins for DCUN1D3 Gene

Gene Ontology (GO) - Biological Process for DCUN1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010225 response to UV-C IDA 18823379
GO:0010332 response to gamma radiation IDA 18823379
GO:0030308 negative regulation of cell growth IMP 18823379
GO:0043065 positive regulation of apoptotic process IMP 18823379
GO:0045116 protein neddylation IBA --
genes like me logo Genes that share ontologies with DCUN1D3: view

No data available for Pathways by source and SIGNOR curated interactions for DCUN1D3 Gene

Drugs & Compounds for DCUN1D3 Gene

No Compound Related Data Available

Transcripts for DCUN1D3 Gene

mRNA/cDNA for DCUN1D3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(198) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCUN1D3 Gene

DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCUN1D3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D3 Gene

No ASD Table

Relevant External Links for DCUN1D3 Gene

GeneLoc Exon Structure for
DCUN1D3
ECgene alternative splicing isoforms for
DCUN1D3

Expression for DCUN1D3 Gene

mRNA expression in normal human tissues for DCUN1D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCUN1D3 Gene

This gene is overexpressed in Breast (47.1) and Bone (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCUN1D3 Gene



SOURCE GeneReport for Unigene cluster for DCUN1D3 Gene Hs.101007

mRNA Expression by UniProt/SwissProt for DCUN1D3 Gene

Q8IWE4-DCNL3_HUMAN
Tissue specificity: Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma.
genes like me logo Genes that share expression patterns with DCUN1D3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for DCUN1D3 Gene

Orthologs for DCUN1D3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCUN1D3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCUN1D3 35
  • 94.3 (n)
  • 97.04 (a)
DCUN1D3 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCUN1D3 35
  • 94.41 (n)
  • 97.37 (a)
DCUN1D3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcun1d3 35
  • 93.2 (n)
  • 97.7 (a)
Dcun1d3 16
Dcun1d3 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCUN1D3 35
  • 99.34 (n)
  • 99.67 (a)
DCUN1D3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcun1d3 35
  • 92.65 (n)
  • 98.03 (a)
oppossum
(Monodelphis domestica)
Mammalia DCUN1D3 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCUN1D3 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCUN1D3 35
  • 77.56 (n)
  • 82.18 (a)
DCUN1D3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCUN1D3 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcun1d3 35
  • 75.39 (n)
  • 78.15 (a)
Str.15235 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14461 35
zebrafish
(Danio rerio)
Actinopterygii zgc:154015 35
  • 67.63 (n)
  • 67.63 (a)
DCUN1D3 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13322 35
  • 54.69 (n)
  • 49.03 (a)
CG13322 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9470 36
  • 23 (a)
OneToOne
Species with no ortholog for DCUN1D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCUN1D3 Gene

ENSEMBL:
Gene Tree for DCUN1D3 (if available)
TreeFam:
Gene Tree for DCUN1D3 (if available)

Paralogs for DCUN1D3 Gene

Paralogs for DCUN1D3 Gene

(3) SIMAP similar genes for DCUN1D3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DCUN1D3 Gene

genes like me logo Genes that share paralogs with DCUN1D3: view

Variants for DCUN1D3 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs17510 -- 20,886,611(-) TTATC(A/G)TGCCA intron-variant
rs1016965 -- 20,872,593(+) ATCCA(C/T)ACAAT intron-variant
rs1858901 -- 20,859,551(+) AAAAA(A/C)AAAAA utr-variant-3-prime
rs1978091 -- 20,875,448(+) TGGAT(A/G)CAAAA intron-variant
rs1978092 -- 20,875,613(+) actat(A/C)tacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D3 Gene

Variant ID Type Subtype PubMed ID
nsv436835 CNV Insertion 17901297
nsv833165 CNV Loss 17160897
esv2714065 CNV Deletion 23290073

Variation tolerance for DCUN1D3 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCUN1D3 Gene

HapMap Linkage Disequilibrium report
DCUN1D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D3 Gene

Disorders for DCUN1D3 Gene

Relevant External Links for DCUN1D3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCUN1D3
genes like me logo Genes that share disorders with DCUN1D3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCUN1D3 Gene

Publications for DCUN1D3 Gene

  1. DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth. (PMID: 18823379) Ma T. … Qiu X. (Cancer Sci. 2008) 23 67
  2. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T. … Peter M. (Nature 2005) 2 67
  3. SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). (PMID: 25349211) Huang G. … Singh B. (J. Biol. Chem. 2014) 67
  4. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda J.K. … Schulman B.A. (Structure 2013) 67
  5. The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. (PMID: 19617556) Meyer-Schaller N. … Peter M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 67

Products for DCUN1D3 Gene

Sources for DCUN1D3 Gene

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