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Aliases for DCUN1D3 Gene

Aliases for DCUN1D3 Gene

  • Defective In Cullin Neddylation 1 Domain Containing 3 2 3 5
  • Defective In Cullin Neddylation Protein 1-Like Protein 3 3 4
  • Squamous Cell Carcinoma-Related Oncogene 3 3 4
  • DCUN1 Domain-Containing Protein 3 3 4
  • SCCRO3 3 4
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 3 (S. Cerevisiae) 2
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 3 3
  • DCN1-Like Protein 3 3
  • 44M2.4 3

External Ids for DCUN1D3 Gene

Previous GeneCards Identifiers for DCUN1D3 Gene

  • GC16M020776
  • GC16M019404

Summaries for DCUN1D3 Gene

GeneCards Summary for DCUN1D3 Gene

DCUN1D3 (Defective In Cullin Neddylation 1 Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is DCUN1D2.

UniProtKB/Swiss-Prot for DCUN1D3 Gene

  • Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D3 Gene

Genomics for DCUN1D3 Gene

Regulatory Elements for DCUN1D3 Gene

Enhancers for DCUN1D3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G020896 1.8 FANTOM5 ENCODE dbSUPER 23.7 -2.3 -2272 11.5 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 DCUN1D3 ACSM3 THUMPD1 ACSM1 LYRM1 CRYM PIR35456
GH16G020909 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.8 -12.0 -12038 5.4 TBP HDGF PKNOX1 FOXA2 ZNF766 GATA2 FOS ETV6 EGR2 ZNF362 DCUN1D3 ACSM3 TMEM159 DNAH3 CRYM ACSM1 THUMPD1 LYRM1 PIR35456
GH16G020864 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +33.9 33884 3.6 PKNOX1 ATF1 ARID4B SIN3A FEZF1 ZNF48 YY1 TCF12 ZNF121 GATA2 ACSM3 THUMPD1 LYRM1 DCUN1D3 DNAH3 TMEM159 PIR58963
GH16G020849 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +49.2 49248 3.1 ARNT SIN3A ARID4B ZNF2 YY1 SLC30A9 GATA2 ZNF143 DEK MXD4 THUMPD1 DCUN1D3 LYRM1 TMEM159 DNAH3 PIR58963
GH16G020871 1.5 Ensembl ENCODE dbSUPER 12.7 +26.7 26670 3.9 PKNOX1 ATF1 ARID4B FEZF1 YY1 TCF12 ZNF766 ELK1 FOS CAVIN1 ACSM3 DCUN1D3 LYRM1 THUMPD1 PIR58963
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCUN1D3 on UCSC Golden Path with GeneCards custom track

Promoters for DCUN1D3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084280 -116 2601 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for DCUN1D3 Gene

Chromosome:
16
Start:
20,854,925 bp from pter
End:
20,900,384 bp from pter
Size:
45,460 bases
Orientation:
Minus strand

Genomic View for DCUN1D3 Gene

Genes around DCUN1D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCUN1D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCUN1D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D3 Gene

Proteins for DCUN1D3 Gene

  • Protein details for DCUN1D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWE4-DCNL3_HUMAN
    Recommended name:
    DCN1-like protein 3
    Protein Accession:
    Q8IWE4
    Secondary Accessions:
    • B3KVY4

    Protein attributes for DCUN1D3 Gene

    Size:
    304 amino acids
    Molecular mass:
    34291 Da
    Quaternary structure:
    • Interacts with CAND1, CUL1, CUL3 and RBX1 through the DCUN1 domain. In vitro, the DCUN1/PONY domain binds UBE2F and, with lower affinity, UBE2M (PubMed:23201271). This interaction is not detected in vivo with full length protein (PubMed:25349211).

    Three dimensional structures from OCA and Proteopedia for DCUN1D3 Gene

neXtProt entry for DCUN1D3 Gene

Post-translational modifications for DCUN1D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCUN1D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCUN1D3 Gene

Domains & Families for DCUN1D3 Gene

Protein Domains for DCUN1D3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCUN1D3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWE4

UniProtKB/Swiss-Prot:

DCNL3_HUMAN :
  • The DCUN1 domain, also known as PONY domain, mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme. This domain is also involved in CAND1-, CUL1-, CUL3- and RBX1-binding.
Domain:
  • The DCUN1 domain, also known as PONY domain, mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme. This domain is also involved in CAND1-, CUL1-, CUL3- and RBX1-binding.
genes like me logo Genes that share domains with DCUN1D3: view

No data available for Gene Families for DCUN1D3 Gene

Function for DCUN1D3 Gene

Molecular function for DCUN1D3 Gene

UniProtKB/Swiss-Prot Function:
Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

Gene Ontology (GO) - Molecular Function for DCUN1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0032182 ubiquitin-like protein binding IBA --
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with DCUN1D3: view

Phenotypes for DCUN1D3 Gene

genes like me logo Genes that share phenotypes with DCUN1D3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D3 Gene

Localization for DCUN1D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D3 Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCUN1D3 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for DCUN1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005886 plasma membrane TAS,IEA --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 18823379
genes like me logo Genes that share ontologies with DCUN1D3: view

Pathways & Interactions for DCUN1D3 Gene

SuperPathways for DCUN1D3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010225 response to UV-C IDA 18823379
GO:0010332 response to gamma radiation IDA 18823379
GO:0030308 negative regulation of cell growth IMP 18823379
GO:0043065 positive regulation of apoptotic process IMP 18823379
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DCUN1D3: view

No data available for Pathways by source and SIGNOR curated interactions for DCUN1D3 Gene

Drugs & Compounds for DCUN1D3 Gene

No Compound Related Data Available

Transcripts for DCUN1D3 Gene

mRNA/cDNA for DCUN1D3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(198) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCUN1D3 Gene

DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D3 Gene

No ASD Table

Relevant External Links for DCUN1D3 Gene

GeneLoc Exon Structure for
DCUN1D3
ECgene alternative splicing isoforms for
DCUN1D3

Expression for DCUN1D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCUN1D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCUN1D3 Gene

This gene is overexpressed in Breast (47.1) and Bone (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCUN1D3 Gene



NURSA nuclear receptor signaling pathways regulating expression of DCUN1D3 Gene:

DCUN1D3

SOURCE GeneReport for Unigene cluster for DCUN1D3 Gene:

Hs.101007

mRNA Expression by UniProt/SwissProt for DCUN1D3 Gene:

Q8IWE4-DCNL3_HUMAN
Tissue specificity: Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma.

Evidence on tissue expression from TISSUES for DCUN1D3 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with DCUN1D3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCUN1D3 Gene

Orthologs for DCUN1D3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCUN1D3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCUN1D3 34 35
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia DCUN1D3 34 35
  • 94.41 (n)
cow
(Bos Taurus)
Mammalia DCUN1D3 34 35
  • 94.3 (n)
mouse
(Mus musculus)
Mammalia Dcun1d3 34 16 35
  • 93.2 (n)
rat
(Rattus norvegicus)
Mammalia Dcun1d3 34
  • 92.65 (n)
oppossum
(Monodelphis domestica)
Mammalia DCUN1D3 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCUN1D3 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCUN1D3 34 35
  • 77.56 (n)
lizard
(Anolis carolinensis)
Reptilia DCUN1D3 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcun1d3 34
  • 75.39 (n)
Str.15235 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.14461 34
zebrafish
(Danio rerio)
Actinopterygii zgc:154015 34
  • 67.63 (n)
DCUN1D3 35
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13322 34 35
  • 54.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9470 35
  • 23 (a)
OneToOne
Species where no ortholog for DCUN1D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCUN1D3 Gene

ENSEMBL:
Gene Tree for DCUN1D3 (if available)
TreeFam:
Gene Tree for DCUN1D3 (if available)

Paralogs for DCUN1D3 Gene

Paralogs for DCUN1D3 Gene

(3) SIMAP similar genes for DCUN1D3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DCUN1D3 Gene

genes like me logo Genes that share paralogs with DCUN1D3: view

Variants for DCUN1D3 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_072689 A cancer
VAR_072690 A cancer
rs1000143115 -- 20,875,681(+) TAGAA(A/G)AAAAC intron-variant
rs1000177459 -- 20,889,290(+) GGGAA(A/G)CTGAG intron-variant
rs1000183700 -- 20,896,657(+) TGAAA(A/G)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D3 Gene

Variant ID Type Subtype PubMed ID
esv2714065 CNV deletion 23290073
esv3638159 CNV loss 21293372
nsv1050009 CNV loss 25217958
nsv1116119 CNV deletion 24896259
nsv436835 CNV insertion 17901297
nsv833165 CNV loss 17160897

Variation tolerance for DCUN1D3 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCUN1D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCUN1D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D3 Gene

Disorders for DCUN1D3 Gene

Relevant External Links for DCUN1D3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCUN1D3

No disorders were found for DCUN1D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCUN1D3 Gene

Publications for DCUN1D3 Gene

  1. SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). (PMID: 25349211) Huang G. … Singh B. (J. Biol. Chem. 2014) 3 4 64
  2. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda J.K. … Schulman B.A. (Structure 2013) 3 4 64
  3. DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth. (PMID: 18823379) Ma T. … Qiu X. (Cancer Sci. 2008) 3 22 64
  4. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T. … Peter M. (Nature 2005) 2 3 64
  5. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. (PMID: 26906416) Keuss M.J. … Kurz T. (J. Cell. Sci. 2016) 3 64

Products for DCUN1D3 Gene

Sources for DCUN1D3 Gene

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