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DCUN1D3 Gene

protein-coding   GIFtS: 45
GCID: GC16M020869

DCN1, Defective In Cullin Neddylation 1, Domain Containing...

(Previous names: DCN1, defective in cullin neddylation 1, domain containing...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DCN1, Defective In Cullin Neddylation 1, Domain Containing 31 2
Defective In Cullin Neddylation Protein 1-Like Protein 32 3
DCUN1 Domain-Containing Protein 32 3
DCN1, Defective In Cullin Neddylation 1, Domain Containing 3 (S.
Cerevisiae)1
44M2.42
DCN1-Like Protein 32

External Ids:    HGNC: 287341   Entrez Gene: 1238792   Ensembl: ENSG000001882157   UniProtKB: Q8IWE43   

Export aliases for DCUN1D3 gene to outside databases

Previous GC identifers: GC16M020776 GC16M019404


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DCUN1D3 Gene:
DCUN1D3 (DCN1, defective in cullin neddylation 1, domain containing 3) is a protein-coding gene. An important paralog of this gene is DCUN1D4.

UniProtKB/Swiss-Prot: DCNL3_HUMAN, Q8IWE4
Function: Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from
the NEDD8-conjugating E2 enzyme UBE2F. Neddylation of cullins play an essential role in the regulation of
SCF-type complexes activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCUN1D3 gene promoter:
         E2F-3a   E2F-4   E2F-5   AP-1   E2F-2   RORalpha1   E2F-1   E2F   STAT3   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCUN1D3 promoter sequence
   Search Chromatin IP Primers for DCUN1D3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCUN1D3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.3   Ensembl cytogenetic band:  16p12.3   HGNC cytogenetic band: 16p12.3

DCUN1D3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCUN1D3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M020869:  view genomic region     (about GC identifiers)

Start:
20,866,247 bp from pter      End:
20,911,706 bp from pter
Size:
45,460 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DCNL3_HUMAN, Q8IWE4 (See protein sequence)
Recommended Name: DCN1-like protein 3  
Size: 304 amino acids; 34291 Da
1 PDB 3D structure from and Proteopedia for DCUN1D3:
4GBA (3D)    
Secondary accessions: B3KVY4

Explore the universe of human proteins at neXtProt for DCUN1D3: NX_Q8IWE4

Explore proteomics data for DCUN1D3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DCUN1D3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775746.1  
    ENSEMBL proteins: 
     ENSP00000319482   ENSP00000454762  

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    Cloud-Clone Corp. Proteins for DCUN1D3

     
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    antibodies-online proteins for DCUN1D3 (7 products) 

     
    antibodies-online peptides for DCUN1D3

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    antibodies-online kits for DCUN1D3 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR005176 PONY_dom
     IPR014764 DCN-prot

    Graphical View of Domain Structure for InterPro Entry Q8IWE4

    ProtoNet protein and cluster: Q8IWE4

    UniProtKB/Swiss-Prot: DCNL3_HUMAN, Q8IWE4
    Domain: The DCUN1 domain, also known as PONY domain mediates recognition of the N-terminally acetylated
    NEDD8-conjugating E2 enzyme (PubMed:23201271)
    Similarity: Contains 1 DCUN1 domain


    Find genes that share domains with DCUN1D3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCNL3_HUMAN, Q8IWE4
    Function: Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from
    the NEDD8-conjugating E2 enzyme UBE2F. Neddylation of cullins play an essential role in the regulation of
    SCF-type complexes activity

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with DCUN1D3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DCUN1D3:
     Decreased Wnt reporter activit 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DCUN1D3

    miRNA
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    miRTarBase miRNAs that target DCUN1D3:
    hsa-mir-18a-5p (MIRT031328)

    Block miRNA regulation of human, mouse, rat DCUN1D3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCUN1D3 (see all 115):
    hsa-miR-549 hsa-miR-140-5p hsa-miR-548j hsa-miR-3938 hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidDCUN1D3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0048471perinuclear region of cytoplasm IDA18823379

    Find genes that share ontologies with DCUN1D3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCUN1D3
    Interactions:

        Search GeneGlobe Interaction Network for DCUN1D3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for DCUN1D3 (ENSP000003194824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC7ENSP000000800594STRING: ENSP00000080059
    COPS5ENSP000003505124STRING: ENSP00000350512
    SKP1ENSP000002314874STRING: ENSP00000231487
    UBA3ENSP000003543404STRING: ENSP00000354340
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010225response to UV-C IDA18823379
    GO:0010332response to gamma radiation IDA18823379
    GO:0030308negative regulation of cell growth IMP18823379
    GO:0043065positive regulation of apoptotic process IMP18823379

    Find genes that share ontologies with DCUN1D3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCUN1D3 (DCNL3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCUN1D3 gene: 
    NM_173475.2  

    Unigene Cluster for DCUN1D3:

    DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
    Hs.101007  [show with all ESTs]
    Unigene Representative Sequence: BC040442
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000324344(uc002dhz.3) ENST00000563934
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DCUN1D3 (see all 115):
    hsa-miR-549 hsa-miR-140-5p hsa-miR-548j hsa-miR-3938 hsa-miR-300 hsa-miR-4272 hsa-miR-106a hsa-miR-200a
    SwitchGear 3'UTR luciferase reporter plasmidDCUN1D3 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCUN1D3
      QuantiTect SYBR Green Assays in human, mouse, rat DCUN1D3
      QuantiFast Probe-based Assays in human, mouse, rat DCUN1D3

    Additional mRNA sequence: 

    AY364247.1 BC040442.1 BX648998.1 

    6 DOTS entries:

    DT.307418  DT.100728255  DT.120704372  DT.100738741  DT.95206956  DT.120704358 

    Selected AceView cDNA sequences (see all 198):

    AA809132 AK123719 AI146837 BF435642 AA707081 BX280488 AW137054 AA281408 
    AA114845 AW780059 AI424831 BI492081 AA971261 AA234468 N58848 AI417800 
    AA977257 N75262 CR622365 BG149914 BX648185 CA866498 AB040937 CA866766 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCUN1D3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DCUN1D3 Expression
    About this image


    DCUN1D3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    DCUN1D3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCUN1D3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.101007
        Custom PCR Arrays for DCUN1D3
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DCUN1D3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcun1d31 , 5 DCN1, defective in cullin neddylation 1, domain containing more1, 5 93.2(n)1
    97.7(a)1
      7 (64.27 cM)5
    2338051  NM_173408.31  NP_775584.11 
     1198531635 
    chicken
    (Gallus gallus)
    Aves DCUN1D31 DCN1, defective in cullin neddylation 1, domain containing more 77.56(n)
    82.18(a)
      427002  XM_004945466.1  XP_004945523.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCUN1D36
    DCN1, defective in cullin neddylation 1, domain co...
    81(a)
    1 ↔ 1
    GL343402.1(809754-827116)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.144612 Xenopus laevis transcribed sequences 81.97(n)    BJ055852.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1540151 zgc:154015 67.63(n)
    67.63(a)
      557682  NM_001103112.1  NP_001096582.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG133221 CG13322 54.69(n)
    49.03(a)
      36426  NM_136984.3  NP_610828.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCN16
    Scaffold-type E3 ligase required for cullin neddyl...
    19(a)
    1 → many
    XII(398530-399433) YLR128W


    ENSEMBL Gene Tree for DCUN1D3 (if available)
    TreeFam Gene Tree for DCUN1D3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCUN1D3 gene
    DCUN1D42  DCUN1D52  DCUN1D12  DCUN1D22  
    3 SIMAP similar genes for DCUN1D3 using alignment to 1 protein entry:     DCNL3_HUMAN:
    DCUN1D1    DCUN1D2    DCUN1D5

    Find genes that share paralogs with DCUN1D3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DCUN1D3
    PGOHUM00000235476


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCUN1D3 (see all 754)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1175364681,2
    C,F--20869012(+) TCAAGA/CGTCTT 1 -- ds50011Minor allele frequency- C:0.01NA 120
    rs99393041,2
    C,F,A,H--20869089(+) CGTGGG/ATGATC 1 -- ds500126Minor allele frequency- A:0.22NS EA NA WA CSA 2765
    rs352099191,2
    C--20869146(+) AAAAAA/-CAAAT 1 -- ds50012Minor allele frequency- -:0.25NA CSA 4
    rs713748361,2
    --20869625(+) GCCAGC/TGCGTG 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs1868202741,2
    --20869974(+) TGAGCC/GTGACT 1 -- ut310--------
    rs1393611281,2
    --20870437(+) ATGTGC/TTCTTA 1 -- ut310--------
    rs784226501,2
    F--20870829(+) AGTCCC/TATCCC 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs795141571,2
    C,F--20870837(+) CCCCCC/TGCCCT 1 -- ut311Minor allele frequency- T:0.12WA 118
    rs18589011,2
    --20870873(+) AAAAAA/CAAAAA 1 -- ut31 trp30--------
    rs615060751,2
    C--20870881(+) AAAAA-/A/CCAAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for DCUN1D3 (20866247 - 20911706 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DCUN1D3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714065CNV Deletion23290073
    nsv436835CNV Insertion17901297
    nsv833165CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCUN1D3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DCUN1D3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PubMed id 23201271)1, 2 Monda J.K....Schulman B.A. (Structure 2013)
    2. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PubMed id 15988528)1, 3 Kurz T....Peter M. (Nature 2005)
    3. DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth. (PubMed id 18823379)1, 9 Ma T....Qiu X. (Cancer Sci. 2008)
    4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    5. NovelFam3000 -- uncharacterized human protein domains conserved across model organisms. (PubMed id 16533400)2 Kemmer D.... Wasserman W.W. (BMC Genomics 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1 Loftus B.J.... Adams M.D. (Genomics 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 123879 HGNC: 28734 AceView: MGC16943andMGC48972 Ensembl:ENSG00000188215 euGenes: HUgn123879
    ECgene: DCUN1D3 H-InvDB: DCUN1D3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCUN1D3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCUN1D3 gene:
    Search GeneIP for patents involving DCUN1D3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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