DCUN1D2 Gene
protein-coding GIFtS : 44
GCID: GC13 M114110
DCN1, defective in cullin neddylation 1, domain containing... (Previous name: chromosome 13 open reading frame 17 ) (Previous symbol: C13orf17 )
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Aliasesfor DCUN1D2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases DCN1, Defective In Cullin Neddylation 1, Domain Containing 2 (S.Cerevisiae) 1 2 FLJ200921 C13orf171 2 3 Chromosome 13 Open Reading Frame 171 Defective In Cullin Neddylation Protein 1-Like Protein 22 3 DCN1-Like Protein 22 DCUN1 Domain-Containing Protein 22 3 DCUN1L23 FLJ107041
Export aliases for DCUN1D2 gene to outside databases Previous GC identifers: GC13M113159 GC13M094549
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Summariesfor DCUN1D2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: DCNL2_HUMAN, Q6PH85 Function : May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation ofcullins play an essential role in the regulation of SCF-type complexes activity (By similarity)
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Genomic Viewsfor DCUN1D2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000013.10 NC_018924.1 NT_027140.6 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DCUN1D2 gene promoter: SREBP-1c HNF-4alpha2 AP-4 SREBP-1b HNF-4alpha1 CREB SREBP-1a deltaCREB c-Myb IRF-7A Other transcription factors Search SABiosciences Chromatin IP Primers for DCUN1D2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q34 DCUN1D2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13M114110: view genomic region
(about GC identifiers )
Start:
114,110,134 bp from pter
End:
114,145,267 bp from pter
Size:
35,134 bases
Orientation:
minus strand
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Proteinsfor DCUN1D2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DCNL2_HUMAN, Q6PH85 (See
protein sequence )Recommended Name: DCN1-like protein 2 Size : 259 amino acids; 30179 Da
Sequence caution : Sequence=BAA90944.1; Type=Erroneous initiation; Sequence=CAI39428.1; Type=Erroneous gene modelprediction; Sequence=CAI39429.1; Type=Erroneous gene model prediction; Sequence=CAI39777.1; Type=Erroneous gene model prediction; Sequence=CAI39778.1; Type=Erroneous gene model prediction; Sequence=CAI39779.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for DCUN1D2 :4GAO (3D)
 
Secondary accessions : Q5JSA5 Q5JSA6 Q5JSA7 Q9NVJ1 Q9NXR6Alternative splicing : 2 isoforms : Q6PH85-1 Q6PH85-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DCUN1D2: NX_Q6PH85 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q6PH85 DCUN1D2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001014305.1 ENSEMBL proteins: ENSP00000364552 ENSP00000330629 ENSP00000417706 ENSP00000403543 ENSP00000418030 ENSP00000417398 ENSP00000414773 ENSP00000417394 ENSP00000364548 Human Recombinant Protein Products: DCUN1D2 Antibody Products: Assay Products for DCUN1D2:
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Protein
Domains / Familiesfor DCUN1D2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DCUN1D2 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6PH85 ProtoNet protein and cluster: Q6PH85
UniProtKB/Swiss-Prot: DCNL2_HUMAN, Q6PH85 Similarity : Contains 1 DCUN1 domainSimilarity : Contains 1 UBA-like domain
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Functionfor DCUN1D2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DCNL2_HUMAN, Q6PH85 Function : May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation ofcullins play an essential role in the regulation of SCF-type complexes activity (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DCUN1D2 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DCUN1D2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DCUN1D2 (NM_001014283 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCUN1D2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DCUN1D2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D2
1 GenomeRNAi human phenotype for DCUN1D2 :
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Pathways & Interactionsfor DCUN1D2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCUN1D2 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)3 Interacting proteins for DCUN1D2 (ENSP00000417706 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table
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Drugs & Compoundsfor DCUN1D2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DCUN1D2 Search CenterWatch for drugs/clinical trials and news about DCUN1D2 / DCNL2
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Transcriptsfor DCUN1D2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DCUN1D2 gene (2 alternative transcripts): NM_018185.2 NM_001014283.1 Unigene Cluster for DCUN1D2:
DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) Hs.369453 [show with all ESTs ] Unigene Representative Sequence: NM_001014283 12 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000375403 (uc001vtr.1 uc001vts.1 ) ENST00000332592 (uc010agw.1 )ENST00000478244 ENST00000482038 ENST00000438545 ENST00000491647 ENST00000465938 ENST00000496873 ENST00000460318 ENST00000439909 ENST00000465710 ENST00000375399 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DCUN1D2 (see all 6 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DCUN1D2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DCUN1D2 (NM_001014283 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCUN1D2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DCUN1D2
Additional cDNA sequence: AK000099.1 BC056669.1
8 DOTS entries : DT.100786436 DT.448073
DT.91722630 DT.120792411 DT.120792374 DT.92421322 DT.100018076 DT.92060962 24/78 AceView cDNA sequences (see all 78 ):
AI307349 AA328421 AA911638 N72738 H97540 AI458019 AA932015 BE504827 AU130439 AK001566 N42513 NM_018185 N29821 AA506104 BP377891 AW592502 AL597390 AA505134 BM807075 CK299626 BU630738 AU130448 AI609538 BX509310 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D2 (see all 9 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b SP1 :   -   -   -   -   -   -   -   -   -                 SP2 :   -   -   -               -   -             SP3 :     -   -                             SP4 :                                   SP5 :                     -   -            
ECgene alternative splicing isoforms for DCUN1D2
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Expression for DCUN1D2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DCUN1D2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTGTGAAATG
About this image DCUN1D2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Heart Left Ventricle Heart Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See DCUN1D2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DCUN1D2 SOURCE GeneReport for Unigene cluster: Hs.369453 SABiosciences Custom PCR Arrays for DCUN1D2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DCUN1D2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DCUN1D2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DCUN1D2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DCUN1D2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D2
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Orthologsfor DCUN1D2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for DCUN1D2 gene from 8/27 species (see all 27 ) About this table
ENSEMBL Gene Tree for DCUN1D2 (if available)TreeFam Gene Tree for DCUN1D2 (if available)
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Paralogsfor DCUN1D2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DCUN1D2 gene DCUN1D4 2 DCUN1D5 2 DCUN1D1 2 DCUN1D3 2 4 SIMAP similar genes for DCUN1D2 using alignment to 7 protein entries: DCNL2_HUMAN (see all proteins ):DCUN1D1 DCUN1D5 DCUN1D4 DCUN1D3
DCUN1D2 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for DCUN1D2 PGOHUM00000236376
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Genomic Variantsfor DCUN1D2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 13 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DCUN1D2 (114110134 - 114145267 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for DCUN1D2 1 CNV : 3928 1 Indel : 25184
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DCUN1D2
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Disorders
/ Diseasesfor DCUN1D2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Publicationsfor DCUN1D2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DCUN1D2 gene integrated from 9 sources : (articles sorted by number of sources associating them with DCUN1D2) Utopia : connect your pdf to the dynamic world of online information
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PubMed id 15988528) 1 , 3 Kurz T....Peter M. (2005) The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823) 1 , 2 Dunham A.... Ross M.T. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 1 Oh J.H....Kim N.S. (2005) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DCUN1D2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DCUN1D2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DCUN1D2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DCUN1D2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DCUN1D2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DCUN1D2 gene: Search GeneIP for patents involving DCUN1D2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DCUN1D2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DCUN1D2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DCUN1D2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DCUN1D2 OriGene Protein Over-expression Lysate for DCUN1D2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DCUN1D2 OriGene 3'-UTR Clone for DCUN1D2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DCUN1D2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DCUN1D2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for DCUN1D2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DCUN1D2 OriGene Custom Protein Services for DCUN1D2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCUN1D2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DCUN1D2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DCUN1D2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DCUN1D2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DCUN1D2
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DCUN1D2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D2
ThermoFisher Antibodies for DCUN1D2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DCUN1D2
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