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Aliases for DCUN1D2 Gene

Aliases for DCUN1D2 Gene

  • Defective In Cullin Neddylation 1 Domain Containing 2 2 3
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 2 3 5
  • Defective In Cullin Neddylation Protein 1-Like Protein 2 3 4
  • DCUN1 Domain-Containing Protein 2 3 4
  • C13orf17 3 4
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 2 (S. Cerevisiae) 2
  • Chromosome 13 Open Reading Frame 17 2
  • DCUN1L2 4

External Ids for DCUN1D2 Gene

Previous HGNC Symbols for DCUN1D2 Gene

  • C13orf17

Previous GeneCards Identifiers for DCUN1D2 Gene

  • GC13M113159
  • GC13M114110
  • GC13M094549

Summaries for DCUN1D2 Gene

GeneCards Summary for DCUN1D2 Gene

DCUN1D2 (Defective In Cullin Neddylation 1 Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is DCUN1D1.

UniProtKB/Swiss-Prot for DCUN1D2 Gene

  • Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D2 Gene

Genomics for DCUN1D2 Gene

Regulatory Elements for DCUN1D2 Gene

Promoters for DCUN1D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCUN1D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCUN1D2 Gene

Chromosome:
13
Start:
113,455,819 bp from pter
End:
113,490,952 bp from pter
Size:
35,134 bases
Orientation:
Minus strand

Genomic View for DCUN1D2 Gene

Genes around DCUN1D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCUN1D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCUN1D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D2 Gene

Proteins for DCUN1D2 Gene

  • Protein details for DCUN1D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PH85-DCNL2_HUMAN
    Recommended name:
    DCN1-like protein 2
    Protein Accession:
    Q6PH85
    Secondary Accessions:
    • Q5JSA5
    • Q5JSA6
    • Q5JSA7
    • Q9NVJ1
    • Q9NXR6

    Protein attributes for DCUN1D2 Gene

    Size:
    259 amino acids
    Molecular mass:
    30179 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA90944.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39428.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39429.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39777.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39778.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI39779.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCUN1D2 Gene

    Alternative splice isoforms for DCUN1D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCUN1D2 Gene

Proteomics data for DCUN1D2 Gene at MOPED

Post-translational modifications for DCUN1D2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DCUN1D2 Gene

Domains & Families for DCUN1D2 Gene

Protein Domains for DCUN1D2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCUN1D2 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PH85

UniProtKB/Swiss-Prot:

DCNL2_HUMAN :
  • The DCUN1 domain, also known as PONY domain mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme.
Domain:
  • The DCUN1 domain, also known as PONY domain mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme.
  • Contains 1 DCUN1 domain.
  • Contains 1 UBA-like domain.
genes like me logo Genes that share domains with DCUN1D2: view

No data available for Gene Families for DCUN1D2 Gene

Function for DCUN1D2 Gene

Molecular function for DCUN1D2 Gene

UniProtKB/Swiss-Prot Function:
Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Gene Ontology (GO) - Molecular Function for DCUN1D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031624 ubiquitin conjugating enzyme binding IBA --
genes like me logo Genes that share ontologies with DCUN1D2: view
genes like me logo Genes that share phenotypes with DCUN1D2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D2 Gene

Localization for DCUN1D2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCUN1D2 Gene COMPARTMENTS Subcellular localization image for DCUN1D2 gene
Compartment Confidence
cytosol 3
plasma membrane 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DCUN1D2 Gene

Pathways & Interactions for DCUN1D2 Gene

SuperPathways for DCUN1D2 Gene

No Data Available

Interacting Proteins for DCUN1D2 Gene

Gene Ontology (GO) - Biological Process for DCUN1D2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCUN1D2 Gene

Drugs & Compounds for DCUN1D2 Gene

No Compound Related Data Available

Transcripts for DCUN1D2 Gene

Unigene Clusters for DCUN1D2 Gene

DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - -
SP4:
SP5: - -
SP6: - - - - - - - - - - -
SP7: - -
SP8: - -
SP9:

Relevant External Links for DCUN1D2 Gene

GeneLoc Exon Structure for
DCUN1D2
ECgene alternative splicing isoforms for
DCUN1D2

Expression for DCUN1D2 Gene

mRNA expression in normal human tissues for DCUN1D2 Gene

mRNA differential expression in normal tissues according to GTEx for DCUN1D2 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.2) and Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for DCUN1D2 Gene

This gene is overexpressed in Testis (34.5), Retina (25.0), and Fetal heart (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCUN1D2 Gene



SOURCE GeneReport for Unigene cluster for DCUN1D2 Gene Hs.682987

genes like me logo Genes that share expression patterns with DCUN1D2: view

Protein tissue co-expression partners for DCUN1D2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DCUN1D2 Gene

Orthologs for DCUN1D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCUN1D2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCUN1D2 35
  • 83.2 (n)
  • 82.61 (a)
DCUN1D2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCUN1D2 35
  • 84.96 (n)
  • 84.15 (a)
DCUN1D2 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcun1d2 35
  • 87 (n)
  • 91.12 (a)
Dcun1d2 16
Dcun1d2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCUN1D2 35
  • 99.18 (n)
  • 98.77 (a)
DCUN1D2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcun1d2 35
  • 86.12 (n)
  • 90.27 (a)
oppossum
(Monodelphis domestica)
Mammalia DCUN1D2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCUN1D2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCUN1D2 35
  • 80.22 (n)
  • 87.97 (a)
DCUN1D2 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCUN1D2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcun1d2 35
  • 78.52 (n)
  • 85.55 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
dcun1d2a 35
  • 76.43 (n)
  • 85.55 (a)
dcun1d2a 36
  • 72 (a)
OneToMany
dcun1d2b 36
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7427 36
  • 52 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dcn-1 35
  • 51.34 (n)
  • 40.73 (a)
dcn-1 36
  • 34 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL194C 35
  • 41.53 (n)
  • 29.24 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D16346g 35
  • 44.54 (n)
  • 30.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 35
  • 43.46 (n)
  • 25.32 (a)
DCN1 36
  • 22 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G12760 35
  • 53.75 (n)
  • 45.83 (a)
rice
(Oryza sativa)
Liliopsida Os06g0233400 35
  • 54.9 (n)
  • 48.74 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.277 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7926 36
  • 44 (a)
OneToMany
Species with no ortholog for DCUN1D2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCUN1D2 Gene

ENSEMBL:
Gene Tree for DCUN1D2 (if available)
TreeFam:
Gene Tree for DCUN1D2 (if available)

Paralogs for DCUN1D2 Gene

Paralogs for DCUN1D2 Gene

(4) SIMAP similar genes for DCUN1D2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for DCUN1D2 Gene

genes like me logo Genes that share paralogs with DCUN1D2: view

Variants for DCUN1D2 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1386 -- 113,455,920(+) AAAAG(A/C)CTTTG nc-transcript-variant, utr-variant-3-prime
rs13705 -- 113,456,092(-) TGAGC(A/G)TATCT nc-transcript-variant, utr-variant-3-prime
rs14067 -- 113,456,345(-) CGATG(C/T)TTCTT nc-transcript-variant, utr-variant-3-prime
rs1131699 -- 113,467,498(+) CCGCT(A/G)Caaaa intron-variant
rs1131700 -- 113,467,499(+) CGCTG(A/C)aaaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D2 Gene

Variant ID Type Subtype PubMed ID
dgv597e1 CNV Complex 17122850
nsv901074 CNV Loss 21882294
nsv456137 CNV Loss 19166990
esv1129275 CNV Deletion 17803354
esv2667164 CNV Deletion 23128226

Variation tolerance for DCUN1D2 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCUN1D2 Gene

HapMap Linkage Disequilibrium report
DCUN1D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D2 Gene

Disorders for DCUN1D2 Gene

Relevant External Links for DCUN1D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCUN1D2

No disorders were found for DCUN1D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCUN1D2 Gene

Publications for DCUN1D2 Gene

  1. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda J.K. … Schulman B.A. (Structure 2013) 3 4 67
  2. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T. … Peter M. (Nature 2005) 2 3
  3. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for DCUN1D2 Gene

Sources for DCUN1D2 Gene

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