Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCUN1D2 Gene

protein-coding   GIFtS: 47
GCID: GC13M114110

DCN1, Defective In Cullin Neddylation 1, Domain Containing...

(Previous names: chromosome 13 open reading frame 17, DCN1, defective in...)
(Previous symbol: C13orf17)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DCN1, Defective In Cullin Neddylation 1, Domain Containing 21 2     Chromosome 13 Open Reading Frame 171
C13orf171 2 3     DCN1, Defective In Cullin Neddylation 1, Domain Containing 2 (S.
Cerevisiae)1
Defective In Cullin Neddylation Protein 1-Like Protein 22 3     DCN1-Like Protein 22
DCUN1 Domain-Containing Protein 22 3     DCUN1L23

External Ids:    HGNC: 203281   Entrez Gene: 552082   Ensembl: ENSG000001504017   UniProtKB: Q6PH853   

Export aliases for DCUN1D2 gene to outside databases

Previous GC identifers: GC13M113159 GC13M094549


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DCUN1D2 Gene: 
DCUN1D2 (DCN1, defective in cullin neddylation 1, domain containing 2) is a protein-coding gene. Diseases associated with DCUN1D2 include gastric cancer. An important paralog of this gene is DCUN1D4.

UniProtKB/Swiss-Prot: DCNL2_HUMAN, Q6PH85
Function: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes.
Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_027140.6  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCUN1D2 gene promoter:
         SREBP-1c   HNF-4alpha2   AP-4   SREBP-1b   HNF-4alpha1   CREB   SREBP-1a   deltaCREB   c-Myb   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCUN1D2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCUN1D2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

DCUN1D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCUN1D2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M114110:  view genomic region     (about GC identifiers)

Start:
114,110,134 bp from pter      End:
114,145,267 bp from pter
Size:
35,134 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCNL2_HUMAN, Q6PH85 (See protein sequence)
Recommended Name: DCN1-like protein 2  
Size: 259 amino acids; 30179 Da
Sequence caution: Sequence=BAA90944.1; Type=Erroneous initiation; Sequence=CAI39428.1; Type=Erroneous gene model
prediction; Sequence=CAI39429.1; Type=Erroneous gene model prediction; Sequence=CAI39777.1; Type=Erroneous gene
model prediction; Sequence=CAI39778.1; Type=Erroneous gene model prediction; Sequence=CAI39779.1; Type=Erroneous
gene model prediction;
1 PDB 3D structure from and Proteopedia for DCUN1D2:
4GAO (3D)    
Secondary accessions: Q5JSA5 Q5JSA6 Q5JSA7 Q9NVJ1 Q9NXR6
Alternative splicing: 2 isoforms:  Q6PH85-1   Q6PH85-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCUN1D2: NX_Q6PH85

Explore proteomics data for DCUN1D2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PH85

  • DCUN1D2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCUN1D2 Protein Expression
    REFSEQ proteins: NP_001014305.1  
    ENSEMBL proteins: 
     ENSP00000364552   ENSP00000330629   ENSP00000417706   ENSP00000403543   ENSP00000418030  
     ENSP00000417398   ENSP00000414773   ENSP00000417394   ENSP00000364548  

    Human Recombinant Protein Products for DCUN1D2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DCUN1D2
    OriGene Protein Over-expression Lysate for DCUN1D2
    OriGene MassSpec for DCUN1D2 
    OriGene Custom Protein Services for DCUN1D2
    GenScript Custom Purified and Recombinant Proteins Services for DCUN1D2
    Novus Biologicals DCUN1D2 Proteins
    Novus Biologicals DCUN1D2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCUN1D2 


    DCUN1D2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DCUN1D2
    GenScript Custom Superior Antibodies Services for DCUN1D2
    Novus Biologicals DCUN1D2 Antibodies
    Abcam antibodies for DCUN1D2
    Cloud-Clone Corp. Antibodies for DCUN1D2 
    ThermoFisher Antibodies for DCUN1D2
    LSBio Antibodies in human, mouse, rat for DCUN1D2 

    Assay Products for DCUN1D2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DCUN1D2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DCUN1D2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DCUN1D2 
    Cloud-Clone Corp. CLIAs for DCUN1D2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR009060 UBA-like
     IPR005176 PONY_dom
     IPR014764 DCN-prot

    Graphical View of Domain Structure for InterPro Entry Q6PH85

    ProtoNet protein and cluster: Q6PH85

    UniProtKB/Swiss-Prot: DCNL2_HUMAN, Q6PH85
    Similarity: Contains 1 DCUN1 domain
    Similarity: Contains 1 UBA-like domain


    DCUN1D2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCNL2_HUMAN, Q6PH85
    Function: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes.
    Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    DCUN1D2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DCUN1D2:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DCUN1D2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DCUN1D2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCUN1D2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCUN1D2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCUN1D2
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate DCUN1D2 (see all 25):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-miR-511 hsa-miR-124 hsa-let-7a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidDCUN1D2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DCUN1D2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCUN1D2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DCUN1D2
    Sirion Biotech Customized adenovirus for overexpression of DCUN1D2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DCUN1D2 (see all 10)
    OriGene ORF clones in mouse, rat for DCUN1D2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCUN1D2 (NM_001014283)
    Sino Biological Human cDNA Clone for DCUN1D2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCUN1D2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D2
    Sirion Biotech Customized lentivirus for stable overexpression of DCUN1D2 
                         Customized lentivirus expression plasmids for stable overexpression of DCUN1D2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DCUN1D2
    Search LifeMap BioReagents cell lines for DCUN1D2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCUN1D2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for DCUN1D2 (ENSP000004177064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1ENSP000003268044STRING: ENSP00000326804
    UBA3ENSP000003543404STRING: ENSP00000354340
    COPS5ENSP000003505124STRING: ENSP00000350512
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCUN1D2 (DCNL2)

    Search CenterWatch for drugs/clinical trials and news about DCUN1D2 / DCNL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCUN1D2 gene (2 alternative transcripts): 
    NM_018185.2  NM_001014283.1  

    Unigene Cluster for DCUN1D2:

    DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)
    Hs.682987  [show with all ESTs]
    Unigene Representative Sequence: NM_001014283
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000375403(uc001vtr.1 uc001vts.1) ENST00000332592(uc010agw.1)
    ENST00000478244 ENST00000482038 ENST00000438545 ENST00000491647 ENST00000465938
    ENST00000496873 ENST00000460318 ENST00000439909 ENST00000465710 ENST00000375399

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCUN1D2
    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate DCUN1D2 (see all 25):
    hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-miR-511 hsa-miR-124 hsa-let-7a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidDCUN1D2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DCUN1D2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCUN1D2
    Clone
    Products:
         
    OriGene clones in human, mouse for DCUN1D2 (see all 10)
    OriGene ORF clones in mouse, rat for DCUN1D2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCUN1D2 (NM_001014283)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCUN1D2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D2
    Sirion Biotech Customized lentivirus for stable overexpression of DCUN1D2 
                         Customized lentivirus expression plasmids for stable overexpression of DCUN1D2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DCUN1D2
    OriGene qSTAR qPCR primer pairs in human, mouse for DCUN1D2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCUN1D2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCUN1D2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCUN1D2

    Additional mRNA sequence: 

    AK000099.1 BC056669.1 

    7 DOTS entries:

    DT.100786436  DT.448073  DT.91722630  DT.120792411  DT.120792374  DT.92421322  DT.92060962 

    24/78 AceView cDNA sequences (see all 78):

    AA911638 AI307349 N72738 N42513 CK299626 AA328421 AW592502 BM807075 
    AA505134 AA506104 AI458019 H97540 AU130439 N29821 BP377891 AA932015 
    AU130448 AK001566 BE504827 BU630738 AL597390 NM_018185 BU601064 BM664935 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:        -     -     -     -     -     -     -     -     -                                             
    SP2:        -     -     -                                         -     -                                 
    SP3:              -     -                                                                                 
    SP4:                                                                                                      
    SP5:                                                              -     -                                 


    ECgene alternative splicing isoforms for DCUN1D2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCUN1D2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGAAATG
    DCUN1D2 Expression
    About this image


    See DCUN1D2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCUN1D2

    SOURCE GeneReport for Unigene cluster: Hs.682987
        SABiosciences Custom PCR Arrays for DCUN1D2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DCUN1D2
    OriGene qSTAR qPCR primer pairs in human, mouse for DCUN1D2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCUN1D2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCUN1D2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCUN1D2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCUN1D2 gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcun1d21 , 5 DCN1, defective in cullin neddylation 1, domain containing more1, 5 87(n)1
    91.12(a)1
      8 (5.73 cM)5
    1023231  NM_001024504.21  NP_001019675.21 
     132559635 
    chicken
    (Gallus gallus)
    Aves DCUN1D21 DCN1, defective in cullin neddylation 1, domain containing more 81.18(n)
    88.63(a)
      418740  XM_416939.3  XP_416939.3 
    lizard
    (Anolis carolinensis)
    Reptilia DCUN1D26
    Uncharacterized protein
    81(a)
    1 ↔ 1
    3(106196849-106216533)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD253185.12   -- 80.07(n)    CD253185.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF265454.12   -- 77.45(n)   192303  CF265454.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74276
    --
    52(a)
    1 → many
    3L(15556527-15558659)
    worm
    (Caenorhabditis elegans)
    Secernentea dcn-11 Protein DCN-1 51.34(n)
    40.73(a)
      175556  NM_065465.4  NP_497866.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCN16
    Scaffold-type E3 ligase required for cullin neddyl...
    22(a)
    1 → many
    XII(398530-399433)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G127601 hypothetical protein 53.89(n)
    45.83(a)
      820458  NM_112112.2  NP_566436.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02334001 hypothetical protein 54.06(n)
    47.9(a)
      4340586  NM_001063767.1  NP_001057232.1 


    ENSEMBL Gene Tree for DCUN1D2 (if available)
    TreeFam Gene Tree for DCUN1D2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCUN1D2 gene
    DCUN1D42  DCUN1D52  DCUN1D12  DCUN1D32  
    4 SIMAP similar genes for DCUN1D2 using alignment to 7 protein entries:     DCNL2_HUMAN (see all proteins):
    DCUN1D1    DCUN1D5    DCUN1D4    DCUN1D3

    DCUN1D2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DCUN1D2
    PGOHUM00000236376


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/824 SNPs in DCUN1D2 are shown (see all 824)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817677321,2
    --114109869(+) CTCCCA/GTAAAT 1 -- int10--------
    rs1403798971,2
    --114109910(+) CATGAC/GCCACC 1 -- int10--------
    rs1851106781,2
    --114109923(+) ATCAGA/GTGCAC 1 -- int10--------
    rs743947841,2
    --114109928(+) GTGCAC/TGGTGC 1 -- int10--------
    rs1895289841,2
    --114109937(+) GCACCA/GCTGAG 1 -- int10--------
    rs1140556871,2
    F--114109968(+) GTACCT/CGAGGA 1 -- int11Minor allele frequency- C:0.03WA 118
    rs771239051,2
    C--114110009(+) CACACG/AGGGGC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs95775521,2
    C,F,A,H--114110012(+) ACGGGG/AGCAGG 1 -- int110Minor allele frequency- A:0.19NS EA NA WA 752
    rs1808796941,2
    --114110065(+) TGGGAC/TAATGA 1 -- int10--------
    rs1865119311,2
    --114110081(+) ATGCTG/TACACC 1 -- int10--------

    HapMap Linkage Disequilibrium report for DCUN1D2 (114110134 - 114145267 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DCUN1D2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1129275CNV Deletion17803354
    esv2667164CNV Deletion23128226
    nsv901074CNV Loss21882294
    nsv456137CNV Loss19166990
    dgv597e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DCUN1D2
    DNA2.0 Custom Variant and Variant Library Synthesis for DCUN1D2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for DCUN1D2:    About MalaCards
    gastric cancer    


    DCUN1D2 for disorders           About GeneDecksing


    Export disorders for DCUN1D2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCUN1D2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DCUN1D2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PubMed id 15988528)1, 3 Kurz T....Peter M. (2005)
    2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Structural conservation of distinctive N-terminal acet ylation-dependent interactions across a family of mammalian NEDD8 ligation enzym es. (PubMed id 23201271)1 Monda J.K....Schulman B.A. (2013)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55208 HGNC: 20328 AceView: C13orf17 Ensembl:ENSG00000150401 euGenes: HUgn55208
    ECgene: DCUN1D2 H-InvDB: DCUN1D2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCUN1D2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCUN1D2 gene:
    Search GeneIP for patents involving DCUN1D2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DCUN1D2  
     OriGene qPCR primer pairs and template standards for DCUN1D2   OriGene Protein Over-expression Lysate for DCUN1D2  
     OriGene MassSpec something-or-other for DCUN1D2   OriGene clones in human, mouse for DCUN1D2  
     OriGene qSTAR qPCR primer pairs in human, mouse for DCUN1D2   OriGene Purified Protein for DCUN1D2  
     OriGene ORF clones in mouse, rat for DCUN1D2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DCUN1D2   OriGene Custom Protein Services for DCUN1D2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCUN1D2
     QIAGEN SeqTarget long-range PCR primers for resequencing DCUN1D2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCUN1D2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCUN1D2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCUN1D2
     GenScript Custom Purified and Recombinant Proteins Services for DCUN1D2 GenScript cDNA clones with any tag delivered in your preferred vector for DCUN1D2
     GenScript Custom Assay Services for DCUN1D2 GenScript Custom Superior Antibodies Services for DCUN1D2
     GenScript Custom overexpressing Cell Line Services for DCUN1D2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DCUN1D2 promoter
     Search Chromatin IP Primers for DCUN1D2
     RT2 qPCR Primer Assay in human, mouse, rat DCUN1D2
     Search GNC Networks for DCUN1D2
     SABiosciences Custom PCR Arrays for DCUN1D2
     Search Tocris compounds for DCUN1D2 (DCNL2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for DCUN1D2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DCUN1D2 antibodies
     DCUN1D2 proteins
     DCUN1D2 lysates
     Antibodies for DCUN1D2
     See all of Abcam's Antibodies, Kits and Proteins for DCUN1D2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DCUN1D2
     Antibodies for DCUN1D2
     ELISAs for DCUN1D2
     CLIAs for DCUN1D2
     Search LifeMap BioReagents cell lines for DCUN1D2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCUN1D2
     SwitchGear 3'UTR luciferase reporter plasmids for DCUN1D2
     SwitchGear Promoter luciferase reporter plasmids for DCUN1D2
     ThermoFisher Antibodies for DCUN1D2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCUN1D2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DCUN1D2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DCUN1D2
    Customized:
     lentivirus for stable overexpression of DCUN1D2
     lentivirus expression plasmids for stable overexpression of DCUN1D2
     adenovirus for overexpression of DCUN1D2
     LSBio Antibodies in human, mouse, rat for DCUN1D2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DCUN1D2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4