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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCUN1D1 Gene

protein-coding   GIFtS: 53
GCID: GC03M182655

DCN1, Defective In Cullin Neddylation 1, Domain Containing...

(Previous names: DCN1, defective in cullin neddylation 1, domain containing...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DCN1, Defective In Cullin Neddylation 1, Domain Containing 11 2     DCUN1 Domain-Containing Protein 12 3
RP422 3 5     DCN1, Defective In Cullin Neddylation 1, Domain Containing 1 (S.
Cerevisiae)1
Squamous Cell Carcinoma Related Oncogene1 2     DCNL12
Defective In Cullin Neddylation Protein 1-Like Protein 12 3     SCRO2
Squamous Cell Carcinoma-Related Oncogene2 3     Tes32
DCUN1L12 3     DCN1-Like Protein 12
SCCRO2 3     RP42 Homolog2

External Ids:    HGNC: 181841   Entrez Gene: 541652   Ensembl: ENSG000000430937   OMIM: 6059055   UniProtKB: Q96GG93   

Export aliases for DCUN1D1 gene to outside databases

Previous GC identifers: GC03M184144 GC03M180065


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DCUN1D1 Gene: 
DCUN1D1 (DCN1, defective in cullin neddylation 1, domain containing 1) is a protein-coding gene. Diseases associated with DCUN1D1 include squamous cell carcinoma, and adrenocortical carcinoma. GO annotations related to this gene include protein binding. An important paralog of this gene is DCUN1D4.

UniProtKB/Swiss-Prot: DCNL1_HUMAN, Q96GG9
Function: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of
E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the
NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on
cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant
transformation and carcinogenic progression (By similarity)

Gene Wiki entry for DCUN1D1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCUN1D1 gene promoter:
         c-Fos   Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   FOXL1   Nkx3-1 v2   FOXJ2 (long isoform)   Nkx3-1 v3   FOXJ2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCUN1D1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCUN1D1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCUN1D1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.3   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q26.3

DCUN1D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCUN1D1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M182655:  view genomic region     (about GC identifiers)

Start:
182,655,862 bp from pter      End:
182,703,741 bp from pter
Size:
47,880 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCNL1_HUMAN, Q96GG9 (See protein sequence)
Recommended Name: DCN1-like protein 1  
Size: 259 amino acids; 30124 Da
Subunit: Part of an E3 complex for neddylation composed of cullins, RBX1, UBE2M and CAND1. Interacts (via the
C-terminus 50 AA) with CUL1, CUL2, CUL3, CUL4 and CUL5. Binds neddylated CUL1. Interacts (via the C-terminus 50
AA) directly with RBX1. Interacts preferentially with UBE2M-NEDD8 thioester (via N-terminus 1-26 AA) than with
free UBE2M. Interacts with CAND1 when in complex with CUL1-RBX1
Sequence caution: Sequence=BAB15235.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for DCUN1D1:
3TDU (3D)        3TDZ (3D)    
Secondary accessions: B2RB37 Q7L3G9 Q8TEX7 Q9H6M1 Q9HCT3

Explore the universe of human proteins at neXtProt for DCUN1D1: NX_Q96GG9

Explore proteomics data for DCUN1D1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96GG9

  • DCUN1D1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCUN1D1 Protein Expression
    REFSEQ proteins: NP_065691.2  
    ENSEMBL proteins: 
     ENSP00000292782   ENSP00000419359   ENSP00000418935   ENSP00000417675   ENSP00000419440  
     ENSP00000418913   ENSP00000420073  

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    ProSpec Recombinant Protein for DCUN1D1
    Cloud-Clone Corp. Proteins for DCUN1D1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA18826954

    DCUN1D1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR009060 UBA-like
     IPR005176 PONY_dom
     IPR014764 DCN-prot

    Graphical View of Domain Structure for InterPro Entry Q96GG9

    ProtoNet protein and cluster: Q96GG9

    UniProtKB/Swiss-Prot: DCNL1_HUMAN, Q96GG9
    Similarity: Contains 1 DCUN1 domain
    Similarity: Contains 1 UBA-like domain


    DCUN1D1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCNL1_HUMAN, Q96GG9
    Function: Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of
    E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the
    NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on
    cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant
    transformation and carcinogenic progression (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18826954
         
    DCUN1D1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidDCUN1D1 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCUN1D1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/39 Interacting proteins for DCUN1D1 (Q96GG92, 3 ENSP000002927824) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224994Q9HCM92, 3, ENSP000004119494MINT-66918 I2D: score=5 STRING: ENSP00000411949
    ENSG00000232839Q9HCM92, 3, ENSP000003983554MINT-66918 I2D: score=5 STRING: ENSP00000398355
    ENSG00000206495Q9HCM92, 3MINT-66918 I2D: score=5 
    ENSG00000226437Q9HCM92, 3MINT-66918 I2D: score=5 
    ENSG00000229929Q9HCM92, 3MINT-66918 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    DCUN1D1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCUN1D1 (DCNL1)

    Search CenterWatch for drugs/clinical trials and news about DCUN1D1 / DCNL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCUN1D1 gene: 
    NM_020640.2  

    Unigene Cluster for DCUN1D1:

    DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)
    Hs.744153  [show with all ESTs]
    Unigene Representative Sequence: NM_020640
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000292782(uc003fld.1) ENST00000469954 ENST00000492563 ENST00000497606
    ENST00000460412 ENST00000487822 ENST00000466812
    miRNA
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    hsa-miR-520e hsa-miR-302d hsa-let-7a-2* hsa-miR-624* hsa-miR-218 hsa-miR-3171 hsa-miR-372 hsa-miR-302b
    SwitchGear 3'UTR luciferase reporter plasmidDCUN1D1 3' UTR sequence
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    Additional mRNA sequence: 

    AF456425.1 AF456426.1 AK025764.1 AK056335.1 AK297328.1 AK314480.1 BC009478.2 BC013163.1 

    11 DOTS entries:

    DT.212784  DT.95078157  DT.95078161  DT.100841630  DT.111313  DT.120917445  DT.97778694  DT.120917451 
    DT.108655  DT.120917420  DT.121333092 

    6 AceView cDNA sequences:

    BE242787 N68059 N78103 AK126909 N58513 BE815468 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCUN1D1 expression in normal human tissues (normalized intensities)      DCUN1D1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DCUN1D1 Expression
    About this image


    DCUN1D1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Proerythroblasts Hematopoietic Bone Marrow
             neutrophils   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             umbilical cord reticulocytes   
     
     Ovary (Reproductive System)
             oocyte   
     
     Breast (Uncategorized)
             breast epithelium   
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud

    See DCUN1D1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCUN1D1

    SOURCE GeneReport for Unigene cluster: Hs.744153

    UniProtKB/Swiss-Prot: DCNL1_HUMAN, Q96GG9
    Tissue specificity: Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver,
    skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant
    tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCUN1D1 gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcun1d11 , 5 DCN1, defective in cullin neddylation 1, domain containing more1, 5 96.14(n)1
    99.23(a)1
      3 (17.41 cM)5
    1148931  NM_001205361.11  NP_001192290.11 
     358929785 
    chicken
    (Gallus gallus)
    Aves DCUN1D11 DCN1, defective in cullin neddylation 1, domain containing more 88.03(n)
    98.84(a)
      424963  NM_001031318.1  NP_001026489.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCUN1D16
    Uncharacterized protein
    80(a)
    1 ↔ 1
    3(204826-223809)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.131962 Xenopus laevis transcribed sequence with strong similarity more 84.49(n)    CF288809.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd19a012 wufd19a01 81.3(n)   327232  BC057530.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG74271 CG7427 61.45(n)
    65.43(a)
      39685  NM_140520.3  NP_648777.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dcn-16
    Defective in cullin neddylation protein 1
    35(a)
    1 → many
    III(4313925-4317577)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCN1(YLR128W)4 Scaffold-type E3 ligase required for cullin neddylation more   --   12(398530-399433) 850819  NP_013229.1 
    soybean
    (Glycine max)
    eudicotyledons 445011482   -- 74.56(n)  


    ENSEMBL Gene Tree for DCUN1D1 (if available)
    TreeFam Gene Tree for DCUN1D1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCUN1D1 gene
    DCUN1D42  DCUN1D52  DCUN1D32  DCUN1D22  
    4 SIMAP similar genes for DCUN1D1 using alignment to 7 protein entries:     DCNL1_HUMAN (see all proteins):
    DCUN1D2    DCUN1D3    DCUN1D5    DCUN1D4

    DCUN1D1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DCUN1D1
    PGOHUM00000243722


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/690 SNPs in DCUN1D1 are shown (see all 690)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446913281,2
    --182660148(+) AAAAGA/GTTTAG 1 -- int10--------
    rs730650931,2
    C,F--182661283(+) AATCAT/CGTAAA 1 -- ut312Minor allele frequency- C:0.02WA 120
    rs1827771151,2
    --182661462(+) CATTTG/TAAGTA 1 -- ut310--------
    rs1867560121,2
    --182661483(+) AGCCTA/GCCTTA 1 -- ut310--------
    rs1443063261,2
    C--182661749(+) CCACAA/GTGATT 1 -- ut310--------
    rs1461083221,2
    --182661782(+) AAATAA/GTAAGT 1 -- ut310--------
    rs1159480631,2
    C,F--182661809(+) TTTGTC/ATGAAA 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1913703411,2
    --182661913(+) TTCCAC/TTTGTG 1 -- ut310--------
    rs10579491,2
    C,F,A,H--182661952(-) GTTTTG/ATTTTT 1 -- ut315Minor allele frequency- A:0.37MN NA 194
    rs1838581531,2
    --182662129(+) TATGCA/GGACAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DCUN1D1 (182655862 - 182703741 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DCUN1D1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508968CNV Insertion20534489
    nsv461031CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605905    OMIM disorders: --

    6 diseases for DCUN1D1:    About MalaCards
    squamous cell carcinoma    adrenocortical carcinoma    esophageal squamous cell carcinoma    esophagitis
    thyroiditis    endotheliitis


    DCUN1D1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DCUN1D1
    Human Genome Epidemiology (HuGE) Navigator: DCUN1D1 (1 document)

    Export disorders for DCUN1D1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCUN1D1 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with DCUN1D1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16. (PubMed id 10777668)1, 2, 3 Mas C....Simonneau M. (2000)
    2. The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. (PubMed id 12796399)1, 2, 9 Estilo C.L.... Singh B. (2003)
    3. Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas. (PubMed id 15657565)1, 2, 9 Sarkaria I.S.... Singh B. (2004)
    4. Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas. (PubMed id 17018598)1, 2, 9 Sarkaria I.... Singh B. (2006)
    5. DCUN1D1 is a risk factor for frontotemporal lobar deg eneration. (PubMed id 19473369)1, 4 Villa C....Galimberti D. (2009)
    6. SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. (PubMed id 18826954)1, 2 Kim A.Y....Singh B. (2008)
    7. Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. (PubMed id 15623817)1, 2 Jacques C.... Reynier P. (2005)
    8. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PubMed id 15988528)1, 3 Kurz T....Peter M. (2005)
    9. Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A. (PubMed id 15123463)1, 2 Talbot S.G.... Singh B. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54165 HGNC: 18184 AceView: RP42.1 Ensembl:ENSG00000043093 euGenes: HUgn54165
    ECgene: DCUN1D1 H-InvDB: DCUN1D1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCUN1D1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCUN1D1 gene:
    Search GeneIP for patents involving DCUN1D1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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