Aliases for DCUN1D1 Gene
External Ids for DCUN1D1 Gene
GeneCards Summary for DCUN1D1 Gene
DCUN1D1 (DCN1, Defective In Cullin Neddylation 1, Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is DCUN1D5.
UniProtKB/Swiss-Prot for DCUN1D1 Gene
Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).