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Aliases for DCUN1D1 Gene

Aliases for DCUN1D1 Gene

  • Defective In Cullin Neddylation 1 Domain Containing 1 2 3 5
  • Defective In Cullin Neddylation Protein 1-Like Protein 1 3 4
  • Squamous Cell Carcinoma-Related Oncogene 3 4
  • DCUN1 Domain-Containing Protein 1 3 4
  • DCUN1L1 3 4
  • SCCRO 3 4
  • RP42 3 4
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) 2
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 1 3
  • Squamous Cell Carcinoma Related Oncogene 2
  • DCN1-Like Protein 1 3
  • RP42 Homolog 3
  • DCNL1 3
  • SCRO 3
  • Tes3 3

External Ids for DCUN1D1 Gene

Previous GeneCards Identifiers for DCUN1D1 Gene

  • GC03M184144
  • GC03M182655
  • GC03M180065

Summaries for DCUN1D1 Gene

GeneCards Summary for DCUN1D1 Gene

DCUN1D1 (Defective In Cullin Neddylation 1 Domain Containing 1) is a Protein Coding gene. Diseases associated with DCUN1D1 include Squamous Cell Carcinoma Of The Oral Tongue and Squamous Cell Carcinoma. An important paralog of this gene is DCUN1D2.

UniProtKB/Swiss-Prot for DCUN1D1 Gene

  • Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

Gene Wiki entry for DCUN1D1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D1 Gene

Genomics for DCUN1D1 Gene

Regulatory Elements for DCUN1D1 Gene

Enhancers for DCUN1D1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G182919 1.3 Ensembl ENCODE 11.7 +64.8 64830 2.3 PKNOX1 ATF1 CREB3L1 ARNT FEZF1 TCF12 ZNF766 GATA2 REST ZNF592 DCUN1D1 ATP11B ENSG00000273261 EIF3EP4
GH03G182925 1 Ensembl ENCODE 11.7 +60.3 60254 1.0 PKNOX1 TBL1XR1 WRNIP1 BACH1 YY1 ARID3A SCRT2 RELB IKZF2 MAFK DCUN1D1 MCCC1 ENSG00000273261 LOC100505642
GH03G182928 0.3 FANTOM5 11.7 +57.8 57753 0.3 DCUN1D1 MCCC1 MCF2L2 ENSG00000273261 LOC100505642
GH03G182924 0.3 FANTOM5 11.7 +61.4 61406 0.3 DCUN1D1 ENSG00000273261 LOC100505642
GH03G183210 1.6 FANTOM5 Ensembl ENCODE 1.2 -226.4 -226394 4.5 ELF3 FOXA2 CBX3 MLX ARID4B DMAP1 YBX1 ZNF48 RAD21 RARA B3GNT5 ATP11B RNA5SP151 KLHL6 LAMP3 MCF2L2 MCCC1 KLHL24 DCUN1D1 SNORD3P4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCUN1D1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCUN1D1 Gene

Chromosome:
3
Start:
182,938,074 bp from pter
End:
182,985,953 bp from pter
Size:
47,880 bases
Orientation:
Minus strand

Genomic View for DCUN1D1 Gene

Genes around DCUN1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCUN1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCUN1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D1 Gene

Proteins for DCUN1D1 Gene

  • Protein details for DCUN1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GG9-DCNL1_HUMAN
    Recommended name:
    DCN1-like protein 1
    Protein Accession:
    Q96GG9
    Secondary Accessions:
    • B2RB37
    • Q7L3G9
    • Q8TEX7
    • Q9H6M1
    • Q9HCT3

    Protein attributes for DCUN1D1 Gene

    Size:
    259 amino acids
    Molecular mass:
    30124 Da
    Quaternary structure:
    • Part of an E3 complex for neddylation composed of cullins, RBX1, UBE2M and CAND1. Interacts (via the C-terminus 50 AA) with CUL1, CUL2, CUL3, CUL4 and CUL5. Binds neddylated CUL1. Interacts (via the C-terminus 50 AA) directly with RBX1. Interacts preferentially with UBE2M-NEDD8 thioester (via N-terminus 1-26 AA) than with free UBE2M. UBE2M N-terminal acetylation increases the affinity of this interaction by about 2 orders of magnitude. Interacts with CAND1 when in complex with CUL1-RBX1.
    SequenceCaution:
    • Sequence=BAB15235.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCUN1D1 Gene

neXtProt entry for DCUN1D1 Gene

Post-translational modifications for DCUN1D1 Gene

  • Ubiquitination at isoforms=36, isoforms=63, isoforms=64, isoforms=143, and Lys191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCUN1D1 Gene

Domains & Families for DCUN1D1 Gene

Protein Domains for DCUN1D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCUN1D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCUN1D1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DCUN1D1 Gene

Function for DCUN1D1 Gene

Molecular function for DCUN1D1 Gene

UniProtKB/Swiss-Prot Function:
Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates (PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

Gene Ontology (GO) - Molecular Function for DCUN1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0032182 ubiquitin-like protein binding IBA --
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with DCUN1D1: view

Phenotypes for DCUN1D1 Gene

GenomeRNAi human phenotypes for DCUN1D1:
genes like me logo Genes that share phenotypes with DCUN1D1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D1 Gene

Localization for DCUN1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCUN1D1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DCUN1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 18826954
GO:0005634 nucleus IDA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with DCUN1D1: view

Pathways & Interactions for DCUN1D1 Gene

SuperPathways for DCUN1D1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0043687 post-translational protein modification TAS --
GO:0045116 protein neddylation IBA --
GO:0051443 positive regulation of ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with DCUN1D1: view

No data available for Pathways by source and SIGNOR curated interactions for DCUN1D1 Gene

Transcripts for DCUN1D1 Gene

Unigene Clusters for DCUN1D1 Gene

DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D1 Gene

No ASD Table

Relevant External Links for DCUN1D1 Gene

GeneLoc Exon Structure for
DCUN1D1
ECgene alternative splicing isoforms for
DCUN1D1

Expression for DCUN1D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCUN1D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCUN1D1 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for DCUN1D1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCUN1D1 Gene



Protein tissue co-expression partners for DCUN1D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCUN1D1 Gene:

DCUN1D1

SOURCE GeneReport for Unigene cluster for DCUN1D1 Gene:

Hs.744153

mRNA Expression by UniProt/SwissProt for DCUN1D1 Gene:

Q96GG9-DCNL1_HUMAN
Tissue specificity: Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.

Evidence on tissue expression from TISSUES for DCUN1D1 Gene

  • Lung(4.4)
  • Nervous system(4.4)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with DCUN1D1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DCUN1D1 Gene

Orthologs for DCUN1D1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCUN1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCUN1D1 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia DCUN1D1 34 35
  • 97.43 (n)
cow
(Bos Taurus)
Mammalia DCUN1D1 34 35
  • 96.99 (n)
mouse
(Mus musculus)
Mammalia Dcun1d1 34 16 35
  • 96.14 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912352 34
  • 95.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCUN1D1 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCUN1D1 34 35
  • 88.03 (n)
lizard
(Anolis carolinensis)
Reptilia DCUN1D1 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcun1d1 34
  • 85.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13196 34
zebrafish
(Danio rerio)
Actinopterygii dcun1d1 34 35
  • 79.25 (n)
wufd19a01 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8737 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004420 34
  • 63.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7427 34 35
  • 61.45 (n)
worm
(Caenorhabditis elegans)
Secernentea dcn-1 35
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 35 37
  • 23 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7349 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7926 35
  • 44 (a)
OneToMany
Species where no ortholog for DCUN1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCUN1D1 Gene

ENSEMBL:
Gene Tree for DCUN1D1 (if available)
TreeFam:
Gene Tree for DCUN1D1 (if available)

Paralogs for DCUN1D1 Gene

Paralogs for DCUN1D1 Gene

(4) SIMAP similar genes for DCUN1D1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for DCUN1D1 Gene

genes like me logo Genes that share paralogs with DCUN1D1: view

Variants for DCUN1D1 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000117400 -- 182,983,600(+) TAGTC(C/T)GGAGG intron-variant
rs1000153757 -- 182,979,974(+) TTGGA(C/G)CCGGG intron-variant, upstream-variant-2KB
rs1000207386 -- 182,947,013(+) AGGAG(A/G)ACTGC intron-variant
rs1000213410 -- 182,955,849(+) GTGCT(C/G)GGATT intron-variant
rs1000224837 -- 182,979,705(+) CCCCA(A/G)GCAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D1 Gene

Variant ID Type Subtype PubMed ID
nsv1073269 CNV deletion 25765185
nsv1126660 CNV deletion 24896259
nsv461031 CNV loss 19166990
nsv477590 CNV novel sequence insertion 20440878
nsv482968 CNV gain 15286789
nsv508968 CNV insertion 20534489
nsv592654 CNV loss 21841781
nsv967097 CNV duplication 23825009

Variation tolerance for DCUN1D1 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCUN1D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCUN1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D1 Gene

Disorders for DCUN1D1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCUN1D1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma of the oral tongue
  • otscc
squamous cell carcinoma
  • epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DCUN1D1

Genetic Association Database (GAD)
DCUN1D1
Human Genome Epidemiology (HuGE) Navigator
DCUN1D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCUN1D1
genes like me logo Genes that share disorders with DCUN1D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCUN1D1 Gene

Publications for DCUN1D1 Gene

  1. Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas. (PMID: 17018598) Sarkaria I. … Singh B. (Cancer Res. 2006) 3 4 22 64
  2. Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas. (PMID: 15657565) Sarkaria I.S. … Singh B. (Surgery 2004) 3 4 22 64
  3. The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. (PMID: 12796399) Estilo C.L. … Singh B. (Clin. Cancer Res. 2003) 3 4 22 64
  4. Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16. (PMID: 10777668) Mas C. … Simonneau M. (Genomics 2000) 2 3 4 64
  5. SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). (PMID: 25349211) Huang G. … Singh B. (J. Biol. Chem. 2014) 3 4 64

Products for DCUN1D1 Gene

Sources for DCUN1D1 Gene

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