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Aliases for DCTPP1 Gene

Aliases for DCTPP1 Gene

  • DCTP Pyrophosphatase 1 2 3 5
  • XTP3-Transactivated Gene A Protein 3 4
  • Deoxycytidine-Triphosphatase 1 3 4
  • XTP3-Transactivated Protein A 2 3
  • DCTPase 1 3 4
  • XTP3TPA 3 4
  • RS21C6 3 4
  • EC 3.6.1.12 4
  • CDA03 3

External Ids for DCTPP1 Gene

Previous GeneCards Identifiers for DCTPP1 Gene

  • GC16M030343
  • GC16M030344
  • GC16M027997

Summaries for DCTPP1 Gene

Entrez Gene Summary for DCTPP1 Gene

  • The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for DCTPP1 Gene

DCTPP1 (DCTP Pyrophosphatase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include identical protein binding and pyrophosphatase activity.

UniProtKB/Swiss-Prot for DCTPP1 Gene

  • Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).

Gene Wiki entry for DCTPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTPP1 Gene

Genomics for DCTPP1 Gene

Regulatory Elements for DCTPP1 Gene

Promoters for DCTPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCTPP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCTPP1 Gene

Chromosome:
16
Start:
30,423,619 bp from pter
End:
30,430,075 bp from pter
Size:
6,457 bases
Orientation:
Minus strand

Genomic View for DCTPP1 Gene

Genes around DCTPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTPP1 Gene

Proteins for DCTPP1 Gene

  • Protein details for DCTPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H773-DCTP1_HUMAN
    Recommended name:
    dCTP pyrophosphatase 1
    Protein Accession:
    Q9H773

    Protein attributes for DCTPP1 Gene

    Size:
    170 amino acids
    Molecular mass:
    18681 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotetramer.

neXtProt entry for DCTPP1 Gene

Proteomics data for DCTPP1 Gene at MOPED

Post-translational modifications for DCTPP1 Gene

  • Ubiquitination at Lys 121 and Lys 140
  • Modification sites at PhosphoSitePlus

Other Protein References for DCTPP1 Gene

Antibody Products

No data available for DME Specific Peptides for DCTPP1 Gene

Domains & Families for DCTPP1 Gene

Protein Domains for DCTPP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H773

UniProtKB/Swiss-Prot:

DCTP1_HUMAN :
  • Contains 1 EAR repeat.
Similarity:
  • Contains 1 EAR repeat.
genes like me logo Genes that share domains with DCTPP1: view

No data available for Gene Families for DCTPP1 Gene

Function for DCTPP1 Gene

Molecular function for DCTPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
dCTP + H(2)O = dCMP + diphosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).

Enzyme Numbers (IUBMB) for DCTPP1 Gene

Gene Ontology (GO) - Molecular Function for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016462 pyrophosphatase activity IEA --
GO:0032556 pyrimidine deoxyribonucleotide binding IEA --
GO:0042802 identical protein binding IPI 16169070
GO:0047429 nucleoside-triphosphate diphosphatase activity IEA,ISS --
GO:0047840 dCTP diphosphatase activity IEA --
genes like me logo Genes that share ontologies with DCTPP1: view

Phenotypes for DCTPP1 Gene

genes like me logo Genes that share phenotypes with DCTPP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTPP1 Gene

Localization for DCTPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTPP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTPP1 Gene COMPARTMENTS Subcellular localization image for DCTPP1 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for DCTPP1 Gene

Pathways & Interactions for DCTPP1 Gene

genes like me logo Genes that share pathways with DCTPP1: view

Pathways by source for DCTPP1 Gene

Gene Ontology (GO) - Biological Process for DCTPP1 Gene

None

No data available for SIGNOR curated interactions for DCTPP1 Gene

Drugs & Compounds for DCTPP1 Gene

(3) Drugs for DCTPP1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
dCMP Experimental Pharma 0
dctp Experimental Pharma 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for DCTPP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with DCTPP1: view

Transcripts for DCTPP1 Gene

Unigene Clusters for DCTPP1 Gene

DCTP pyrophosphatase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTPP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for DCTPP1 Gene

GeneLoc Exon Structure for
DCTPP1
ECgene alternative splicing isoforms for
DCTPP1

Expression for DCTPP1 Gene

mRNA expression in normal human tissues for DCTPP1 Gene

Protein differential expression in normal tissues from HIPED for DCTPP1 Gene

This gene is overexpressed in Lung (8.5) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTPP1 Gene



SOURCE GeneReport for Unigene cluster for DCTPP1 Gene Hs.632191

genes like me logo Genes that share expression patterns with DCTPP1: view

Protein tissue co-expression partners for DCTPP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTPP1 Gene

Orthologs for DCTPP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCTPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTPP1 35
  • 99.41 (n)
  • 98.82 (a)
DCTPP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCTPP1 36
  • 80 (a)
OneToOne
DCTPP1 35
  • 84.83 (n)
  • 80.24 (a)
dog
(Canis familiaris)
Mammalia DCTPP1 35
  • 87.06 (n)
  • 81.76 (a)
-- 36
  • 56 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dctpp1 16
Dctpp1 36
  • 76 (a)
OneToOne
Dctpp1 35
  • 78.63 (n)
  • 75.88 (a)
oppossum
(Monodelphis domestica)
Mammalia DCTPP1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCTPP1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctpp1 35
  • 79.61 (n)
  • 75.29 (a)
lizard
(Anolis carolinensis)
Reptilia DCTPP1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctpp1 35
  • 63.64 (n)
  • 65.29 (a)
Str.5848 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1175 35
zebrafish
(Danio rerio)
Actinopterygii DCTPP1 36
  • 50 (a)
OneToOne
zgc73273 35
zgc:73273 35
  • 62.3 (n)
  • 63.93 (a)
rice
(Oryza sativa)
Liliopsida Os02g0479300 35
  • 56.51 (n)
  • 57.81 (a)
Species with no ortholog for DCTPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCTPP1 Gene

ENSEMBL:
Gene Tree for DCTPP1 (if available)
TreeFam:
Gene Tree for DCTPP1 (if available)

Paralogs for DCTPP1 Gene

No data available for Paralogs for DCTPP1 Gene

Variants for DCTPP1 Gene

Sequence variations from dbSNP and Humsavar for DCTPP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4788415 -- 30,427,988(+) agacc(C/T)tttct intron-variant
rs8059970 -- 30,431,622(+) cgggc(A/G)gatca upstream-variant-2KB
rs10678492 -- 30,430,404(+) AAATC(-/TCTC)AGGGC upstream-variant-2KB
rs11641974 -- 30,430,331(+) AAAGC(C/G)AAACG upstream-variant-2KB
rs12164987 -- 30,426,725(+) gacgg(A/C)gtctt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTPP1 Gene

Variant ID Type Subtype PubMed ID
nsv905724 CNV Loss 21882294

Variation tolerance for DCTPP1 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTPP1 Gene

HapMap Linkage Disequilibrium report
DCTPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTPP1 Gene

Disorders for DCTPP1 Gene

Relevant External Links for DCTPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTPP1

No disorders were found for DCTPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTPP1 Gene

Publications for DCTPP1 Gene

  1. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. (PMID: 15740738) Moroz O.V. … Galperin M.Y. (J. Mol. Biol. 2005) 2 3 23 67
  2. Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks. (PMID: 24550385) Abu-Odeh M. … Aqeilan R.I. (J. Biol. Chem. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells. (PMID: 24467396) Requena C.E. … GonzA!lez-Pacanowska D. (Biochem. J. 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for DCTPP1 Gene

Sources for DCTPP1 Gene

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