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Aliases for DCTPP1 Gene

Aliases for DCTPP1 Gene

  • DCTP Pyrophosphatase 1 2 3 5
  • XTP3-Transactivated Gene A Protein 3 4
  • Deoxycytidine-Triphosphatase 1 3 4
  • XTP3-Transactivated Protein A 2 3
  • DCTPase 1 3 4
  • XTP3TPA 3 4
  • RS21C6 3 4
  • EC 3.6.1.12 4
  • CDA03 3

External Ids for DCTPP1 Gene

Previous GeneCards Identifiers for DCTPP1 Gene

  • GC16M030343
  • GC16M030344
  • GC16M027997

Summaries for DCTPP1 Gene

Entrez Gene Summary for DCTPP1 Gene

  • The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for DCTPP1 Gene

DCTPP1 (DCTP Pyrophosphatase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include identical protein binding and pyrophosphatase activity.

UniProtKB/Swiss-Prot for DCTPP1 Gene

  • Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.

Gene Wiki entry for DCTPP1 Gene

Additional gene information for DCTPP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTPP1 Gene

Genomics for DCTPP1 Gene

Regulatory Elements for DCTPP1 Gene

Enhancers for DCTPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H030633 1.8 FANTOM5 Ensembl ENCODE 11.5 -204.6 -204626 2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 ZNF688 ZNF689 FBRS CCDC189 TGFB1I1 LOC730183 MIR762HG PHKG2 ZNF764 SRCAP
GH16H030547 1.5 Ensembl ENCODE dbSUPER 11.8 -118.9 -118898 2 PKNOX1 ATF1 ARNT FEZF1 GLI4 ZNF2 TCF12 FOS ATF7 NCOA1 ZNF689 ZNF764 SETD1A ENSG00000239791 ZNF688 ZNF785 DCTPP1 ENSG00000222701 ITGAL SEPHS2
GH16H030538 1.5 Ensembl ENCODE dbSUPER 11.6 -111.3 -111327 5 PKNOX1 ATF1 MLX ARNT ARID4B DMAP1 TCF12 ZNF121 ZNF302 FOS ZNF764 ZNF785 INO80E ENSG00000235560 SRCAP SMG1P2 ENSG00000260267 SMG1P5 ENSG00000260304 ENSG00000260114
GH16H030598 1.4 Ensembl ENCODE 11.8 -168.2 -168227 0 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF302 ZNF143 SP3 SRCAP INO80E ENSG00000260267 FBRS SETD1A ZNF764 PRR14 RNF40 SMG1P5 ENSG00000260304
GH16H030649 1.4 ENCODE dbSUPER 11.4 -221.2 -221175 3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 SETD1A ENSG00000260267 TGFB1I1 SMG1P5 SRCAP ENSG00000260304 BCL7C ZNF747 FUS NDUFA3P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCTPP1 on UCSC Golden Path with GeneCards custom track

Promoters for DCTPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085197 275 1201 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766

Genomic Location for DCTPP1 Gene

Chromosome:
16
Start:
30,423,619 bp from pter
End:
30,430,075 bp from pter
Size:
6,457 bases
Orientation:
Minus strand

Genomic View for DCTPP1 Gene

Genes around DCTPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTPP1 Gene

Proteins for DCTPP1 Gene

  • Protein details for DCTPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H773-DCTP1_HUMAN
    Recommended name:
    dCTP pyrophosphatase 1
    Protein Accession:
    Q9H773

    Protein attributes for DCTPP1 Gene

    Size:
    170 amino acids
    Molecular mass:
    18681 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotetramer.

neXtProt entry for DCTPP1 Gene

Post-translational modifications for DCTPP1 Gene

  • Ubiquitination at isoforms=121 and isoforms=140
  • Modification sites at PhosphoSitePlus

Other Protein References for DCTPP1 Gene

No data available for DME Specific Peptides for DCTPP1 Gene

Domains & Families for DCTPP1 Gene

Gene Families for DCTPP1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DCTPP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCTPP1: view

No data available for UniProtKB/Swiss-Prot for DCTPP1 Gene

Function for DCTPP1 Gene

Molecular function for DCTPP1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=47.6 uM for dCTP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396}; KM=65 uM for dTTP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396}; KM=79.3 uM for dATP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396}; KM=75.9 uM for dUTP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396}; KM=16.8 uM for 5I-dCTP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396}; KM=36.5 uM for 5Br-dCTP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396}; KM=33.3 uM for 5me-dCTP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396}; KM=62.9 uM for 5hme-dCTP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396}; KM=9.2 uM for 5fo-dCTP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396}; KM=142.9 uM for CTP (at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:24467396};
UniProtKB/Swiss-Prot CatalyticActivity:
dCTP + H(2)O = dCMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the reaction end product PPi. Inhibited by dCDP. Inhibited by triptolide.
UniProtKB/Swiss-Prot Function:
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
UniProtKB/Swiss-Prot Induction:
Up-regulated by an increase in cellular dCTP pool.

Enzyme Numbers (IUBMB) for DCTPP1 Gene

Gene Ontology (GO) - Molecular Function for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS,IEA --
GO:0005515 protein binding IPI 16189514
GO:0016462 pyrophosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0032556 pyrimidine deoxyribonucleotide binding IEA --
genes like me logo Genes that share ontologies with DCTPP1: view

Phenotypes for DCTPP1 Gene

genes like me logo Genes that share phenotypes with DCTPP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCTPP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTPP1 Gene

Localization for DCTPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTPP1 Gene

Mitochondrion. Nucleus. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTPP1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24467396
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IDA,IEA 24467396
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with DCTPP1: view

Pathways & Interactions for DCTPP1 Gene

genes like me logo Genes that share pathways with DCTPP1: view

Pathways by source for DCTPP1 Gene

Gene Ontology (GO) - Biological Process for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006253 dCTP catabolic process IMP 24467396
GO:0009143 nucleoside triphosphate catabolic process ISS --
GO:0042262 DNA protection IMP 24467396
GO:0046076 NOT dTTP catabolic process IMP 24467396
GO:0051289 protein homotetramerization IEA --
genes like me logo Genes that share ontologies with DCTPP1: view

No data available for SIGNOR curated interactions for DCTPP1 Gene

Drugs & Compounds for DCTPP1 Gene

(4) Drugs for DCTPP1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
dCMP Experimental Pharma 0
dctp Experimental Pharma 0
Triptonide Pharma 0

(1) Additional Compounds for DCTPP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(1) ApexBio Compounds for DCTPP1 Gene

Compound Action Cas Number
Triptonide 38647-11-9
genes like me logo Genes that share compounds with DCTPP1: view

Drug Products

Transcripts for DCTPP1 Gene

Unigene Clusters for DCTPP1 Gene

DCTP pyrophosphatase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCTPP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DCTPP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for DCTPP1 Gene

GeneLoc Exon Structure for
DCTPP1
ECgene alternative splicing isoforms for
DCTPP1

Expression for DCTPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCTPP1 Gene

Protein differential expression in normal tissues from HIPED for DCTPP1 Gene

This gene is overexpressed in Lung (8.5) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCTPP1 Gene



Protein tissue co-expression partners for DCTPP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCTPP1 Gene:

DCTPP1

SOURCE GeneReport for Unigene cluster for DCTPP1 Gene:

Hs.632191

Evidence on tissue expression from TISSUES for DCTPP1 Gene

  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with DCTPP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTPP1 Gene

Orthologs for DCTPP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCTPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTPP1 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia DCTPP1 33
  • 87.06 (n)
-- 34
  • 82 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DCTPP1 33 34
  • 84.83 (n)
rat
(Rattus norvegicus)
Mammalia Dctpp1 33
  • 79.61 (n)
mouse
(Mus musculus)
Mammalia Dctpp1 33 16 34
  • 78.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCTPP1 34
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCTPP1 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCTPP1 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctpp1 33
  • 63.64 (n)
Str.5848 33
zebrafish
(Danio rerio)
Actinopterygii zgc:73273 33
  • 62.3 (n)
DCTPP1 34
  • 50 (a)
OneToOne
zgc73273 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1175 33
rice
(Oryza sativa)
Liliopsida Os02g0479300 33
  • 56.51 (n)
Species where no ortholog for DCTPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCTPP1 Gene

ENSEMBL:
Gene Tree for DCTPP1 (if available)
TreeFam:
Gene Tree for DCTPP1 (if available)

Paralogs for DCTPP1 Gene

No data available for Paralogs for DCTPP1 Gene

Variants for DCTPP1 Gene

Sequence variations from dbSNP and Humsavar for DCTPP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000009593 -- 30,431,556(+) GATAA(A/G)GAAAC upstream-variant-2KB
rs1000158976 -- 30,427,911(+) TGGGA(A/G)GATCG intron-variant
rs1000478071 -- 30,429,580(+) TGCCC(C/T)TCTCG intron-variant
rs1000712503 -- 30,427,551(+) TTTTC(C/T)TCATA intron-variant
rs1001386470 -- 30,428,276(+) CTGGG(C/T)ACTTG intron-variant

Variation tolerance for DCTPP1 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCTPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCTPP1 Gene

Disorders for DCTPP1 Gene

Relevant External Links for DCTPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTPP1

No disorders were found for DCTPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTPP1 Gene

Publications for DCTPP1 Gene

  1. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. (PMID: 15740738) Moroz OV … Galperin MY (Journal of molecular biology 2005) 2 3 22 60
  2. The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells. (PMID: 24467396) Requena CE … González-Pacanowska D (The Biochemical journal 2014) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3 60
  5. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60

Products for DCTPP1 Gene

Sources for DCTPP1 Gene

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