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Aliases for DCTPP1 Gene

Aliases for DCTPP1 Gene

  • DCTP Pyrophosphatase 1 2 3
  • XTP3-Transactivated Gene A Protein 3 4
  • Deoxycytidine-Triphosphatase 1 3 4
  • XTP3-Transactivated Protein A 2 3
  • DCTPase 1 3 4
  • XTP3TPA 3 4
  • RS21C6 3 4
  • EC 3.6.1.12 4
  • CDA03 3

External Ids for DCTPP1 Gene

Previous GeneCards Identifiers for DCTPP1 Gene

  • GC16M030343
  • GC16M030344
  • GC16M027997

Summaries for DCTPP1 Gene

GeneCards Summary for DCTPP1 Gene

DCTPP1 (DCTP Pyrophosphatase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include magnesium ion binding and pyrimidine deoxyribonucleotide binding.

UniProtKB/Swiss-Prot for DCTPP1 Gene

  • Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).

Gene Wiki entry for DCTPP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTPP1 Gene

Genomics for DCTPP1 Gene

Regulatory Elements for DCTPP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCTPP1 Gene

Start:
30,423,619 bp from pter
End:
30,430,075 bp from pter
Size:
6,457 bases
Orientation:
Minus strand

Genomic View for DCTPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCTPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTPP1 Gene

Proteins for DCTPP1 Gene

  • Protein details for DCTPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H773-DCTP1_HUMAN
    Recommended name:
    dCTP pyrophosphatase 1
    Protein Accession:
    Q9H773
    Secondary Accessions:

    Protein attributes for DCTPP1 Gene

    Size:
    170 amino acids
    Molecular mass:
    18681 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Probably binds two or three Mg(2+) ions per subunit.;
    Quaternary structure:
    • Homotetramer.

neXtProt entry for DCTPP1 Gene

Proteomics data for DCTPP1 Gene at MOPED

Post-translational modifications for DCTPP1 Gene

  • Ubiquitination at Lys121 and Lys140
  • Modification sites at PhosphoSitePlus

Other Protein References for DCTPP1 Gene

Antibody Products

No data available for DME Specific Peptides for DCTPP1 Gene

Domains for DCTPP1 Gene

Protein Domains for DCTPP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H773

UniProtKB/Swiss-Prot:

DCTP1_HUMAN :
  • Q9H773
Similarity:
  • Contains 1 EAR repeat.
genes like me logo Genes that share domains with DCTPP1: view

No data available for Gene Families for DCTPP1 Gene

Function for DCTPP1 Gene

Molecular function for DCTPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: dCTP + H(2)O = dCMP + diphosphate
UniProtKB/Swiss-Prot Function: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).

Enzyme Numbers (IUBMB) for DCTPP1 Gene

Gene Ontology (GO) - Molecular Function for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0005515 protein binding IPI 25416956
GO:0016462 pyrophosphatase activity --
GO:0032556 pyrimidine deoxyribonucleotide binding IEA --
GO:0042802 identical protein binding IPI 16169070
genes like me logo Genes that share ontologies with DCTPP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTPP1

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCTPP1 Gene

Localization for DCTPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTPP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTPP1 Gene COMPARTMENTS Subcellular localization image for DCTPP1 gene
Compartment Confidence
cytosol 4
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol ISS --
genes like me logo Genes that share ontologies with DCTPP1: view

Pathways for DCTPP1 Gene

SuperPathways for DCTPP1 Gene

genes like me logo Genes that share pathways with DCTPP1: view

Pathways by source for DCTPP1 Gene

2 KEGG pathways for DCTPP1 Gene

Gene Ontology (GO) - Biological Process for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009143 nucleoside triphosphate catabolic process ISS --
GO:0051289 protein homotetramerization IEA --
genes like me logo Genes that share ontologies with DCTPP1: view

Transcripts for DCTPP1 Gene

Unigene Clusters for DCTPP1 Gene

DCTP pyrophosphatase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTPP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DCTPP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTPP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for DCTPP1 Gene

GeneLoc Exon Structure for
DCTPP1
ECgene alternative splicing isoforms for
DCTPP1

Expression for DCTPP1 Gene

mRNA expression in normal human tissues for DCTPP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTPP1 Gene

SOURCE GeneReport for Unigene cluster for DCTPP1 Gene Hs.632191

genes like me logo Genes that share expressions with DCTPP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTPP1 Gene

Orthologs for DCTPP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCTPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTPP1 35
  • 99.41 (n)
  • 98.82 (a)
DCTPP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCTPP1 35
  • 84.83 (n)
  • 80.24 (a)
DCTPP1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
DCTPP1 35
  • 87.06 (n)
  • 81.76 (a)
mouse
(Mus musculus)
Mammalia Dctpp1 35
  • 78.63 (n)
  • 75.88 (a)
Dctpp1 16
Dctpp1 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCTPP1 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCTPP1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctpp1 35
  • 79.61 (n)
  • 75.29 (a)
lizard
(Anolis carolinensis)
Reptilia DCTPP1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctpp1 35
  • 63.64 (n)
  • 65.29 (a)
Str.5848 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1175 35
zebrafish
(Danio rerio)
Actinopterygii DCTPP1 36
  • 50 (a)
OneToOne
zgc73273 35
zgc:73273 35
  • 62.3 (n)
  • 63.93 (a)
rice
(Oryza sativa)
Liliopsida Os02g0479300 35
  • 56.51 (n)
  • 57.81 (a)
Species with no ortholog for DCTPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCTPP1 Gene

ENSEMBL:
Gene Tree for DCTPP1 (if available)
TreeFam:
Gene Tree for DCTPP1 (if available)

Paralogs for DCTPP1 Gene

No data available for Paralogs for DCTPP1 Gene

Variants for DCTPP1 Gene

Sequence variations from dbSNP and Humsavar for DCTPP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs4788415 -- 30,427,988(+) agacc(C/T)tttct intron-variant
rs8045758 -- 30,431,777(+) ggagg(C/T)ggagc upstream-variant-2KB
rs8059970 -- 30,431,622(+) cgggc(A/G)gatca upstream-variant-2KB
rs10678492 -- 30,430,404(+) AAATC(-/TCTC)AGGGC upstream-variant-2KB
rs11541538 -- 30,424,401(-) CTGCC(A/G/T)CTAGC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for DCTPP1 Gene

Variant ID Type Subtype PubMed ID
nsv905724 CNV Loss 21882294

Relevant External Links for DCTPP1 Gene

HapMap Linkage Disequilibrium report
DCTPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTPP1 Gene

Disorders for DCTPP1 Gene

No disorders were found for DCTPP1 Gene.

No data available for UniProtKB/Swiss-Prot for DCTPP1 Gene

Publications for DCTPP1 Gene

  1. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. (PMID: 15740738) Moroz O.V. … Galperin M.Y. (J. Mol. Biol. 2005) 2 3 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for DCTPP1 Gene

Sources for DCTPP1 Gene

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