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Aliases for DCTPP1 Gene

Aliases for DCTPP1 Gene

  • DCTP Pyrophosphatase 1 2 3 5
  • XTP3-Transactivated Gene A Protein 3 4
  • Deoxycytidine-Triphosphatase 1 3 4
  • XTP3-Transactivated Protein A 2 3
  • DCTPase 1 3 4
  • XTP3TPA 3 4
  • RS21C6 3 4
  • EC 3.6.1.12 4
  • CDA03 3

External Ids for DCTPP1 Gene

Previous GeneCards Identifiers for DCTPP1 Gene

  • GC16M030343
  • GC16M030344
  • GC16M027997

Summaries for DCTPP1 Gene

Entrez Gene Summary for DCTPP1 Gene

  • The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for DCTPP1 Gene

DCTPP1 (DCTP Pyrophosphatase 1) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include identical protein binding and pyrophosphatase activity.

UniProtKB/Swiss-Prot for DCTPP1 Gene

  • Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).

Gene Wiki entry for DCTPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTPP1 Gene

Genomics for DCTPP1 Gene

Regulatory Elements for DCTPP1 Gene

Enhancers for DCTPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F030633 1.8 FANTOM5 Ensembl ENCODE 11.5 -204.7 -204726 2.8 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FOS CCDC189 ZNF764 ZNF688 SRCAP ZNF785 ENSG00000239791 FBRS DCTPP1 ZNF629 RNU6-1043P
GH16F030598 1.4 Ensembl ENCODE 11.8 -168.3 -168326 0.8 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ENSG00000260267 ZNF764 ENSG00000260304 ENSG00000235560 PRR14 NPIPB13 NDUFA3P6 ENSG00000261475 VN1R65P ENSG00000261648
GH16F030547 1.3 Ensembl ENCODE 11.8 -118.9 -118898 2.4 ATF1 PKNOX1 ARNT FEZF1 GLI4 ZNF2 FOS JUNB NCOA1 REST ZNF689 ZNF764 ENSG00000239791 ZNF688 ZNF785 DCTPP1 ENSG00000222701 ITGAL SEPHS2 ZNF768
GH16F030538 1.3 Ensembl ENCODE 11.6 -111.3 -111327 5.3 PKNOX1 ATF1 ARNT MLX ARID4B DMAP1 ZNF48 ZNF121 ZNF302 FOS ZNF764 ZNF785 CD2BP2 ENSG00000235560 SMG1P2 ENSG00000260267 ENSG00000260304 ENSG00000239791 ZNF688 BCL7C
GH16F030491 1.2 Ensembl ENCODE 11.9 -61.9 -61914 0.8 HDGF PKNOX1 ARNT CBX5 FOS REST MBD2 MIER3 SMARCA4 PBX2 SEPHS2 ENSG00000239791 ZNF688 ZNF785 DCTPP1 ZNF689 ENSG00000199787 TBC1D10B RNU6-1043P SRCAP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCTPP1 on UCSC Golden Path with GeneCards custom track

Promoters for DCTPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000271920 375 1801 HDGF CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for DCTPP1 Gene

Chromosome:
16
Start:
30,423,619 bp from pter
End:
30,430,075 bp from pter
Size:
6,457 bases
Orientation:
Minus strand

Genomic View for DCTPP1 Gene

Genes around DCTPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTPP1 Gene

Proteins for DCTPP1 Gene

  • Protein details for DCTPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H773-DCTP1_HUMAN
    Recommended name:
    dCTP pyrophosphatase 1
    Protein Accession:
    Q9H773

    Protein attributes for DCTPP1 Gene

    Size:
    170 amino acids
    Molecular mass:
    18681 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homotetramer.

neXtProt entry for DCTPP1 Gene

Post-translational modifications for DCTPP1 Gene

  • Ubiquitination at Lys 121 and Lys 140
  • Modification sites at PhosphoSitePlus

Other Protein References for DCTPP1 Gene

No data available for DME Specific Peptides for DCTPP1 Gene

Domains & Families for DCTPP1 Gene

Protein Domains for DCTPP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H773

UniProtKB/Swiss-Prot:

DCTP1_HUMAN :
  • Contains 1 EAR repeat.
Similarity:
  • Contains 1 EAR repeat.
genes like me logo Genes that share domains with DCTPP1: view

No data available for Gene Families for DCTPP1 Gene

Function for DCTPP1 Gene

Molecular function for DCTPP1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
dCTP + H(2)O = dCMP + diphosphate.
UniProtKB/Swiss-Prot Function:
Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity).

Enzyme Numbers (IUBMB) for DCTPP1 Gene

Gene Ontology (GO) - Molecular Function for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA,ISS --
GO:0005515 protein binding IPI 16189514
GO:0016462 pyrophosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0032556 pyrimidine deoxyribonucleotide binding IEA --
genes like me logo Genes that share ontologies with DCTPP1: view

Phenotypes for DCTPP1 Gene

genes like me logo Genes that share phenotypes with DCTPP1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTPP1 Gene

Localization for DCTPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTPP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTPP1 gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2

Gene Ontology (GO) - Cellular Components for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,ISS --
genes like me logo Genes that share ontologies with DCTPP1: view

Pathways & Interactions for DCTPP1 Gene

genes like me logo Genes that share pathways with DCTPP1: view

Pathways by source for DCTPP1 Gene

Gene Ontology (GO) - Biological Process for DCTPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009143 nucleoside triphosphate catabolic process IEA,ISS --
GO:0051289 protein homotetramerization IEA --
genes like me logo Genes that share ontologies with DCTPP1: view

No data available for SIGNOR curated interactions for DCTPP1 Gene

Drugs & Compounds for DCTPP1 Gene

(4) Drugs for DCTPP1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
dCMP Experimental Pharma 0
dctp Experimental Pharma 0
Triptonide Pharma 0

(1) Additional Compounds for DCTPP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(1) ApexBio Compounds for DCTPP1 Gene

Compound Action Cas Number
Triptonide 38647-11-9
genes like me logo Genes that share compounds with DCTPP1: view

Transcripts for DCTPP1 Gene

Unigene Clusters for DCTPP1 Gene

DCTP pyrophosphatase 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTPP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for DCTPP1 Gene

GeneLoc Exon Structure for
DCTPP1
ECgene alternative splicing isoforms for
DCTPP1

Expression for DCTPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCTPP1 Gene

Protein differential expression in normal tissues from HIPED for DCTPP1 Gene

This gene is overexpressed in Lung (8.5) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCTPP1 Gene



Protein tissue co-expression partners for DCTPP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCTPP1 Gene:

DCTPP1

SOURCE GeneReport for Unigene cluster for DCTPP1 Gene:

Hs.632191
genes like me logo Genes that share expression patterns with DCTPP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTPP1 Gene

Orthologs for DCTPP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCTPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTPP1 34 35
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia DCTPP1 34
  • 87.06 (n)
-- 35
  • 82 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
cow
(Bos Taurus)
Mammalia DCTPP1 34 35
  • 84.83 (n)
rat
(Rattus norvegicus)
Mammalia Dctpp1 34
  • 79.61 (n)
mouse
(Mus musculus)
Mammalia Dctpp1 34 16 35
  • 78.63 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCTPP1 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCTPP1 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCTPP1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctpp1 34
  • 63.64 (n)
Str.5848 34
zebrafish
(Danio rerio)
Actinopterygii zgc:73273 34
  • 62.3 (n)
DCTPP1 35
  • 50 (a)
OneToOne
zgc73273 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1175 34
rice
(Oryza sativa)
Liliopsida Os02g0479300 34
  • 56.51 (n)
Species where no ortholog for DCTPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCTPP1 Gene

ENSEMBL:
Gene Tree for DCTPP1 (if available)
TreeFam:
Gene Tree for DCTPP1 (if available)

Paralogs for DCTPP1 Gene

No data available for Paralogs for DCTPP1 Gene

Variants for DCTPP1 Gene

Sequence variations from dbSNP and Humsavar for DCTPP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10678492 -- 30,430,404(+) AAATC(-/TCTC)AGGGC upstream-variant-2KB
rs111795097 -- 30,423,752(+) AGAAC(A/G)ATTAA nc-transcript-variant, utr-variant-3-prime
rs113148422 -- 30,425,073(+) CAGGG(-/T)TTTGC intron-variant
rs113214102 -- 30,428,474(+) CAGAG(A/G)AAAAG intron-variant
rs113394991 -- 30,426,851(+) TGTGC(C/G)ACCAT intron-variant

Variation tolerance for DCTPP1 Gene

Residual Variation Intolerance Score: 75.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTPP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCTPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCTPP1 Gene

Disorders for DCTPP1 Gene

Relevant External Links for DCTPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTPP1

No disorders were found for DCTPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTPP1 Gene

Publications for DCTPP1 Gene

  1. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. (PMID: 15740738) Moroz O.V. … Galperin M.Y. (J. Mol. Biol. 2005) 2 3 22 64
  2. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3 64
  3. Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation. (PMID: 26075750) Song F.F. … Wang Y. (Oncogenesis 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for DCTPP1 Gene

Sources for DCTPP1 Gene

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