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DCTPP1 Gene

protein-coding   GIFtS: 51
GCID: GC16M030435

DCTP Pyrophosphatase 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DCTP Pyrophosphatase 11 2     XTP3TPA2 3
XTP3-Transactivated Protein A1 2     DCTPase 12 3
Deoxycytidine-Triphosphatase 12 3     XTP3-Transactivated Gene A Protein2 3
RS21C62 3     EC 3.6.1.123

External Ids:    HGNC: 287771   Entrez Gene: 790772   Ensembl: ENSG000001799587   UniProtKB: Q9H7733   

Export aliases for DCTPP1 gene to outside databases

Previous GC identifers: GC16M030343 GC16M030344 GC16M027997


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DCTPP1 Gene:
DCTPP1 (dCTP pyrophosphatase 1) is a protein-coding gene. GO annotations related to this gene include pyrimidine deoxyribonucleotide binding and magnesium ion binding.

UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773
Function: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a
strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified
dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has
even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP,
dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May
protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity)

Gene Wiki entry for DCTPP1 (XTP3-transactivated gene A protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCTPP1 gene promoter:
         c-Fos   AP-1   Sp1   IRF-1   GATA-1   c-Jun   Pax-4a   AP-2alpha   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCTPP1 promoter sequence
   Search Chromatin IP Primers for DCTPP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCTPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

DCTPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTPP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030435:  view genomic region     (about GC identifiers)

Start:
30,434,940 bp from pter      End:
30,441,396 bp from pter
Size:
6,457 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773 (See protein sequence)
Recommended Name: dCTP pyrophosphatase 1  
Size: 170 amino acids; 18681 Da
Cofactor: Magnesium. Probably binds two or three magnesium ions per subunit (By similarity)
Subunit: Homotetramer (By similarity)

Explore the universe of human proteins at neXtProt for DCTPP1: NX_Q9H773

Explore proteomics data for DCTPP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys121, Lys140
  • Modification sites at PhosphoSitePlus

  • See DCTPP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077001.1  
    ENSEMBL proteins: 
     ENSP00000322524   ENSP00000456612   ENSP00000455391   ENSP00000460764   ENSP00000460933  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004518 MazG_cat
     IPR009039 EAR

    Graphical View of Domain Structure for InterPro Entry Q9H773

    ProtoNet protein and cluster: Q9H773

    UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773
    Similarity: Contains 1 EAR repeat


    Find genes that share domains with DCTPP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCTP1_HUMAN, Q9H773
    Function: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a
    strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified
    dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has
    even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP,
    dCDP or dGTP. May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May
    protect cells against inappropriate methylation of CpG islands by DNA methyltransferases (By similarity)
    Catalytic activity: dCTP + H(2)O = dCMP + diphosphate

         Enzyme Number (IUBMB): EC 3.6.1.121

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0016462pyrophosphatase activity ----
    GO:0032556pyrimidine deoxyribonucleotide binding IEA--
    GO:0047429nucleoside-triphosphate diphosphatase activity ISS--
    GO:0047840dCTP diphosphatase activity IEA--
         
    Find genes that share ontologies with DCTPP1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DCTPP1

    miRNA
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    miRTarBase miRNAs that target DCTPP1:
    hsa-mir-1 (MIRT023878), hsa-mir-615-3p (MIRT040115), hsa-mir-34a-5p (MIRT025514), hsa-mir-106b-5p (MIRT044359), hsa-mir-17-5p (MIRT050878), hsa-mir-26b-5p (MIRT029875), hsa-let-7b-5p (MIRT005221)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCTP1_HUMAN, Q9H773: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--

    Find genes that share ontologies with DCTPP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCTPP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Pyrimidine metabolism0.38
    2Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with DCTPP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for DCTPP1):
        Pyrimidine metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCTPP1
    Interactions:

        Search GeneGlobe Interaction Network for DCTPP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for DCTPP1 (Q9H7733 ENSP000003225244) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    NIF3L1Q9GZT83, ENSP000003863944I2D: score=4 STRING: ENSP00000386394
    PLK1P533503, ENSP000003000934I2D: score=2 STRING: ENSP00000300093
    WDYHV1Q96HA83, ENSP000002873874I2D: score=4 STRING: ENSP00000287387
    NOA1Q8NC603I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009143nucleoside triphosphate catabolic process ISS--
    GO:0051289protein homotetramerization IEA--

    Find genes that share ontologies with DCTPP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCTPP1 (DCTP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCTPP1 gene: 
    NM_024096.1  

    Unigene Cluster for DCTPP1:

    DCTP pyrophosphatase 1
    Hs.632191  [show with all ESTs]
    Unigene Representative Sequence: BQ061429
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319285(uc002dyf.3) ENST00000567983 ENST00000568434 ENST00000568973
    ENST00000565758
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat DCTPP1

    Additional mRNA sequence: 

    AF210430.1 AF212242.1 AK024843.1 AY453409.1 BC001344.1 CR457335.1 

    9 DOTS entries:

    DT.216989  DT.100637763  DT.100783304  DT.100783312  DT.99976339  DT.100045542  DT.100045546  DT.100783309 
    DT.95106408 

    Selected AceView cDNA sequences (see all 263):

    BQ052714 AA878116 N98369 AL558339 BM783913 BQ932765 AF210430 CR624207 
    BM016781 BQ445910 AI127138 CR599989 BE254037 BU070506 BI835091 AA321128 
    AI083701 CR616490 CA425821 BM756921 AA962572 AW515602 BU539197 AF212242 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DCTPP1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
    SP1:              -     -     -                                 
    SP2:                    -     -                                 
    SP3:                          -                                 
    SP4:                                                            


    ECgene alternative splicing isoforms for DCTPP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCTPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAGTTCCTT
    DCTPP1 Expression
    About this image

    DCTPP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCTPP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632191
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCTPP1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dctpp11 , 5 dCTP pyrophosphatase 11, 5 78.63(n)1
    75.88(a)1
      7 (69.42 cM)5
    664221  NM_023203.11  NP_075692.11 
     1272569595 
    lizard
    (Anolis carolinensis)
    Reptilia DCTPP16
    dCTP pyrophosphatase 1
    58(a)
    1 ↔ 1
    GL343516.1(290808-293314)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.58482 Transcribed sequence with weak similarity to protein more 74.03(n)    AL874573.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732732 hypothetical protein MGC73273 74.07(n)   393744  BC059602.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g04793001 Os02g0479300 56.51(n)
    57.81(a)
      4329363  NM_001053383.1  NP_001046848.1 


    ENSEMBL Gene Tree for DCTPP1 (if available)
    TreeFam Gene Tree for DCTPP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCTPP1 (see all 154)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897847991,2
    --30434559(+) AAACCC/TCATCT 1 -- int10--------
    rs1507805671,2
    --30434593(+) CCGGGC/TGTGGT 1 -- int10--------
    rs1817515551,2
    --30434712(+) TGGGCA/GAAAGA 1 -- int10--------
    rs1869196271,2
    --30434855(+) CATACC/TGCCGC 1 -- int10--------
    rs1919657831,2
    --30434859(+) CCGCCA/GCACTC 1 -- int10--------
    rs355559121,2
    C,F--30434897(-) TTTTTT/-GAGAC 1 -- int13Minor allele frequency- -:0.50NA 6
    rs1391548731,2
    C--30435000(+) ACTCAC/TTGAAA 1 -- int10--------
    rs1117950971,2
    C--30435073(+) AGAACA/GATTAA 1 -- ut310--------
    rs1817293721,2
    --30435100(+) TAGCTC/TGCAAG 1 -- ut310--------
    rs1425119881,2
    --30435115(+) AAAGAC/TGGCAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DCTPP1 (30434940 - 30441396 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DCTPP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905724CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCTPP1 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with DCTPP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential &quot;house-cleaning&quot; functions. (PubMed id 15740738)1, 3, 9 Moroz O.V....Galperin M.Y. (J. Mol. Biol. 2005)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    3. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Triptolide directly inhibits dCTP pyrophosphatase. (PubMed id 21671327)1 Corson T.W....Crews C.M. (Chembiochem 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79077 HGNC: 28777 AceView: XTP3TPA Ensembl:ENSG00000179958 euGenes: HUgn79077
    ECgene: DCTPP1 Kegg: 79077 H-InvDB: DCTPP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCTPP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCTPP1 gene:
    Search GeneIP for patents involving DCTPP1

    GeneCards and IP:
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