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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCTPP1 Gene

protein-coding   GIFtS: 46
GCID: GC16M030435

dCTP pyrophosphatase 1

  Search for DCTPP1
in our new
 Human Malady Compendium 
Biological research products
for DCTPP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DCTP Pyrophosphatase 11 2     XTP3-Transactivated Gene A Protein2 3
RS21C61 2 3     CDA031
XTP3TPA1 2 3     MGC56271
Deoxycytidine-Triphosphatase 12 3     XTP3-Transactivated Protein A2
DCTPase 12 3     EC 3.6.1.123

External Ids:    HGNC: 287771   Entrez Gene: 790772   Ensembl: ENSG000001799587   UniProtKB: Q9H7733   

Export aliases for DCTPP1 gene to outside databases

Previous GC identifers: GC16M030343 GC16M030344 GC16M027997


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773
Function: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong
preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP,
5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower
activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP.
May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against
inappropriate methylation of CpG islands by DNA methyltransferases (By similarity)

Gene Wiki entry for DCTPP1 (XTP3-transactivated gene A protein)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCTPP1 gene promoter:
         c-Fos   AP-1   Sp1   IRF-1   GATA-1   c-Jun   Pax-4a   AP-2alpha   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCTPP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCTPP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCTPP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

DCTPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTPP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M030435:  view genomic region     (about GC identifiers)

Start:
30,434,940 bp from pter      End:
30,441,396 bp from pter
Size:
6,457 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773 (See protein sequence)
Recommended Name: dCTP pyrophosphatase 1  
Size: 170 amino acids; 18681 Da
Cofactor: Magnesium. Probably binds two or three magnesium ions per subunit (By similarity)
Subunit: Homotetramer (By similarity)
Subcellular location: Cytoplasm (By similarity)

Explore the universe of human proteins at neXtProt for DCTPP1: NX_Q9H773

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H773

  • DCTPP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_077001.1  
    ENSEMBL proteins: 
     ENSP00000322524   ENSP00000456612   ENSP00000455391   ENSP00000460764   ENSP00000460933  

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    ProSpec Recombinant Protein for DCTPP1
    Uscn Proteins for DCTPP1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol ISS--


    DCTPP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DCTPP1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004518 MazG_cat
     IPR009039 EAR

    Graphical View of Domain Structure for InterPro Entry Q9H773

    ProtoNet protein and cluster: Q9H773

    UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773
    Similarity: Contains 1 EAR repeat


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773
    Function: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong
    preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP,
    5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower
    activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP.
    May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells against
    inappropriate methylation of CpG islands by DNA methyltransferases (By similarity)
    Catalytic activity: dCTP + H(2)O = dCMP + diphosphate

    Enzyme Number (IUBMB): EC 3.6.1.121

    miRNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ISS--
    GO:0016462pyrophosphatase activity ----
    GO:0032556pyrimidine deoxyribonucleotide binding IEA--
    GO:0047429nucleoside-triphosphate diphosphatase activity ISS--
    GO:0047840dCTP diphosphatase activity IEA--


    DCTPP1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCTPP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/9 Interacting proteins for DCTPP1 (Q9H7733 ENSP000003225244) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    NIF3L1Q9GZT83, ENSP000003863944I2D: score=4 STRING: ENSP00000386394
    PLK1P533503, ENSP000003000934I2D: score=2 STRING: ENSP00000300093
    WDYHV1Q96HA83, ENSP000002873874I2D: score=4 STRING: ENSP00000287387
    NOA1Q8NC603I2D: score=3 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009143nucleoside triphosphate catabolic process ISS--
    GO:0051289protein homotetramerization IEA--


    DCTPP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCTPP1
    Search CenterWatch for drugs/clinical trials and news about DCTPP1 / DCTP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCTPP1 gene: 
    NM_024096.1  

    Unigene Cluster for DCTPP1:

    DCTP pyrophosphatase 1
    Hs.632191  [show with all ESTs]
    Unigene Representative Sequence: BQ061429
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319285(uc002dyf.3) ENST00000567983 ENST00000568434 ENST00000568973
    ENST00000565758

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    Inhib. RNA
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    Additional cDNA sequence: 

    AF210430.1 AF212242.1 AK024843.1 AY453409.1 BC001344.1 CR457335.1 

    9 DOTS entries:

    DT.216989  DT.100637763  DT.100783304  DT.100783312  DT.99976339  DT.100045542  DT.100045546  DT.100783309 
    DT.95106408 

    24/263 AceView cDNA sequences (see all 263):

    BC001344 BU158581 AW769252 BM718547 BU171159 BQ052714 BQ932765 AF212242 
    AI127138 BM970062 BM783913 BG220902 BM794965 BE378101 BQ445910 AK024843 
    AA355494 CR614028 BM552152 CR599989 N98369 CR624207 BE254037 AA878116 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DCTPP1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d
    SP1:              -     -     -                                 
    SP2:                    -     -                                 
    SP3:                          -                                 
    SP4:                                                            


    ECgene alternative splicing isoforms for DCTPP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCTPP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAAGTTCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DCTPP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCTPP1

    SOURCE GeneReport for Unigene cluster: Hs.632191
        SABiosciences Custom PCR Arrays for DCTPP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTPP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCTPP1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dctpp11 , 5 dCTP pyrophosphatase 11, 5 78.63(n)1
    75.88(a)1
      7 (69.42 cM)5
    664221  NM_023203.11  NP_075692.11 
     1272569595 
    lizard
    (Anolis carolinensis)
    Reptilia DCTPP16
    --
    56(a)
    1 ↔ 1
    GL343516.1(290808-293314)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.58482 Transcribed sequence with weak similarity to protein more 74.03(n)    AL874573.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732732 hypothetical protein MGC73273 74.07(n)   393744  BC059602.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G254006
    uncharacterized protein
    38(a)
    1 ↔ 1
    3(9213156-9214281)
    rice
    (Oryza sativa)
    Liliopsida Os02g04793001 hypothetical protein 56.51(n)
    57.81(a)
      4329363  NM_001053383.1  NP_001046848.1 


    ENSEMBL Gene Tree for DCTPP1 (if available)
    TreeFam Gene Tree for DCTPP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/110 NCBI SNPs in DCTPP1 are shown (see all 110    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897847991,2
    --30434559(+) AAACCC/TCATCT 1 -- int10--------
    rs1507805671,2
    --30434593(+) CCGGGC/TGTGGT 1 -- int10--------
    rs1817515551,2
    --30434712(+) TGGGCA/GAAAGA 1 -- int10--------
    rs1869196271,2
    --30434855(+) CATACC/TGCCGC 1 -- int10--------
    rs1919657831,2
    --30434859(+) CCGCCA/GCACTC 1 -- int10--------
    rs355559121,2
    C,F--30434897(-) TTTTTT/-GAGAC 1 -- int13Minor allele frequency- -:0.50NA 6
    rs1391548731,2
    --30435000(+) ACTCAC/TTGAAA 1 -- int10--------
    rs1817293721,2
    --30435100(+) TAGCTC/TGCAAG 1 -- ut310--------
    rs1425119881,2
    --30435115(+) AAAGAC/TGGCAT 1 -- ut310--------
    rs133375011,2
    C,F,H--30435466(+) TCTATT/CCTGAA 1 -- ut317Minor allele frequency- C:0.01NS EA NA 592

    HapMap Linkage Disequilibrium report for DCTPP1 (30434940 - 30441396 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DCTPP1: --

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCTPP1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with DCTPP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential 'house-cleaning' functions. (PubMed id 15740738)1, 3, 9 Moroz O.V....Galperin M.Y. (2005)
    2. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    3. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    9. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PubMed id 19596235)1 Svendsen J.M.... Harper J.W. (2009)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79077 HGNC: 28777 AceView: XTP3TPA Ensembl:ENSG00000179958 euGenes: HUgn79077
    ECgene: DCTPP1 H-InvDB: DCTPP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCTPP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCTPP1 gene:
    Search GeneIP for patents involving DCTPP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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