DCTPP1 Gene
protein-coding GIFtS: 46
GCID: GC16M030435
|
|
dCTP pyrophosphatase 1
| |
Aliases for DCTPP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| DCTP Pyrophosphatase 11 2 | | XTP3-Transactivated Gene A Protein2 3 | | RS21C61 2 3 | | CDA031 | | XTP3TPA1 2 3 | | MGC56271 | | Deoxycytidine-Triphosphatase 12 3 | | XTP3-Transactivated Protein A2 | | DCTPase 12 3 | | EC 3.6.1.123 |
Export aliases for DCTPP1 gene to outside databasesPrevious GC identifers: GC16M030343 GC16M030344 GC16M027997 |
Summaries for DCTPP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773Function: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strongpreference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP,5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even loweractivity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP.May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells againstinappropriate methylation of CpG islands by DNA methyltransferases (By similarity) Gene Wiki entry for DCTPP1 (XTP3-transactivated gene A protein)
|
Genomic Views for DCTPP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DCTPP1 gene promoter: c-Fos AP-1 Sp1 IRF-1 GATA-1 c-Jun Pax-4a AP-2alpha NF-Y CBF(2) Other transcription factors
Search SABiosciences Chromatin IP Primers for DCTPP1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCTPP1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2DCTPP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M030435: view genomic region
(about GC identifiers)
Start:
|
30,434,940 bp from pter |
End:
|
30,441,396 bp from pter |
Size:
|
6,457 bases |
Orientation:
|
minus strand |
|
Proteins for DCTPP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773 (See
protein sequence)Recommended Name: dCTP pyrophosphatase 1 Size: 170 amino acids; 18681 Da
Cofactor: Magnesium. Probably binds two or three magnesium ions per subunit (By similarity)
Subunit: Homotetramer (By similarity)
Subcellular location: Cytoplasm (By similarity)Explore the universe of human proteins at neXtProt for DCTPP1: NX_Q9H773
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H773 DCTPP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_077001.1 ENSEMBL proteins: ENSP00000322524 ENSP00000456612 ENSP00000455391 ENSP00000460764 ENSP00000460933 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
ISS | -- |
DCTPP1 for ontologies About GeneDecksing
DCTPP1 Antibody Products: Assay Products for DCTPP1: |
Protein
Domains / Families for DCTPP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCTPP1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H773ProtoNet protein and cluster: Q9H773 UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773Similarity: Contains 1 EAR repeat |
Function for DCTPP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: DCTP1_HUMAN, Q9H773Function: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strongpreference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP,5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even loweractivity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP.May protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. May protect cells againstinappropriate methylation of CpG islands by DNA methyltransferases (By similarity)Catalytic activity: dCTP + H(2)O = dCMP + diphosphateEnzyme Number (IUBMB): EC 3.6.1.121
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCTPP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCTPP1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTPP1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000287 | magnesium ion binding |
ISS | -- | | GO:0016462 | pyrophosphatase activity |
-- | -- | | GO:0032556 | pyrimidine deoxyribonucleotide binding |
IEA | -- | | GO:0047429 | nucleoside-triphosphate diphosphatase activity |
ISS | -- | | GO:0047840 | dCTP diphosphatase activity |
IEA | -- |
DCTPP1 for ontologies About GeneDecksing
|
Pathways & Interactions for DCTPP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCTPP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
 5/9 Interacting proteins for DCTPP1 (Q9H7733 ENSP000003225244) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009143 | nucleoside triphosphate catabolic process |
ISS | -- | | GO:0051289 | protein homotetramerization |
IEA | -- |
DCTPP1 for ontologies About GeneDecksing
|
Drugs & Compounds for DCTPP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DCTPP1 Search CenterWatch for drugs/clinical trials and news about DCTPP1 / DCTP1 
|
Transcripts for DCTPP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DCTPP1 gene: NM_024096.1 Unigene Cluster for DCTPP1: DCTP pyrophosphatase 1 Hs.632191 [show with all ESTs]Unigene Representative Sequence: BQ0614295 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000319285(uc002dyf.3) ENST00000567983 ENST00000568434 ENST00000568973 ENST00000565758
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCTPP1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCTPP1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DCTPP1 (NM_024096) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCTPP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTPP1  |
Additional cDNA sequence: AF210430.1 AF212242.1 AK024843.1 AY453409.1 BC001344.1 CR457335.1 9 DOTS entries: DT.216989 DT.100637763 DT.100783304 DT.100783312 DT.99976339 DT.100045542 DT.100045546 DT.100783309 DT.95106408 24/263 AceView cDNA sequences (see all 263): BC001344 BU158581 AW769252 BM718547 BU171159 BQ052714 BQ932765 AF212242 AI127138 BM970062 BM783913 BG220902 BM794965 BE378101 BQ445910 AK024843 AA355494 CR614028 BM552152 CR599989 N98369 CR624207 BE254037 AA878116 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for DCTPP1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | · | 4d | |
| SP1: | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for DCTPP1
|
Expression for DCTPP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCTPP1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAAGTTCCTT
About this image See DCTPP1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DCTPP1
SOURCE GeneReport for Unigene cluster: Hs.632191 SABiosciences Custom PCR Arrays for DCTPP1
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCTPP1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCTPP1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCTPP1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCTPP1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTPP1 |
Orthologs for DCTPP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DCTPP1 gene from 6/15 species (see all 15) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Dctpp11 , 5 |
dCTP pyrophosphatase 11, 5 |
78.63(n)1 75.88(a)1 |
  |
7 (69.42 cM)5 664221 NM_023203.11 NP_075692.11 1272569595 |
lizard (Anolis carolinensis) |
Reptilia |
DCTPP16 |
-- |
56(a) |
1 ↔ 1 |
GL343516.1(290808-293314) |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.58482 |
Transcribed sequence with weak similarity to protein more |
74.03(n) |
  |
AL874573.2 |
zebrafish (Danio rerio) |
Actinopterygii |
zgc732732 |
hypothetical protein MGC73273 |
74.07(n) |
  |
393744 BC059602.1 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT3G254006 |
uncharacterized protein |
38(a) |
1 ↔ 1 |
3(9213156-9214281) |
rice (Oryza sativa) |
Liliopsida |
Os02g04793001 |
hypothetical protein |
56.51(n) 57.81(a) |
  |
4329363 NM_001053383.1 NP_001046848.1 |
ENSEMBL Gene Tree for DCTPP1 (if available) TreeFam Gene Tree for DCTPP1 (if available)  |
Paralogs for DCTPP1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for DCTPP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 16 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for DCTPP1 (30434940 - 30441396 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DCTPP1: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCTPP1 |
|
Disorders
/ Diseases for DCTPP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications for DCTPP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCTPP1 gene, integrated from 9 sources (see all 18): (articles sorted by number of sources associating them with DCTPP1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential 'house-cleaning' functions. (PubMed id 15740738)1, 3, 9 Moroz O.V....Galperin M.Y. (2005)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. (PubMed id 19596235)1 Svendsen J.M.... Harper J.W. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for DCTPP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DCTPP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCTPP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCTPP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DCTPP1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCTPP1 gene: Search GeneIP for patents involving DCTPP1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DCTPP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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