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Aliases for DCTN6 Gene

Aliases for DCTN6 Gene

  • Dynactin Subunit 6 2 3 5
  • Dynactin Subunit P27 3 4
  • Protein WS-3 3 4
  • Dynactin 6 2 3
  • WS3 3 4
  • Novel RGD-Containing Protein 3
  • WS-3 3
  • P27 3

External Ids for DCTN6 Gene

Previous GeneCards Identifiers for DCTN6 Gene

  • GC08P029929
  • GC08P030464
  • GC08P029870
  • GC08P030071
  • GC08P028558
  • GC08P030013

Summaries for DCTN6 Gene

Entrez Gene Summary for DCTN6 Gene

  • The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCTN6 Gene

DCTN6 (Dynactin Subunit 6) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include dynein binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN6 Gene

Genomics for DCTN6 Gene

Regulatory Elements for DCTN6 Gene

Enhancers for DCTN6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F029796 0.2 Ensembl 4.9 -359.1 -359097 1.2 DUSP4 DCTN6 GC08P029814 LINC02099
GH08F030155 1.1 ENCODE 0.8 +0.6 569 3.5 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 WRN RBPMS-AS1 LEPROTL1 SARAF DUSP4 HSPA8P11 DCTN6 MBOAT4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCTN6 on UCSC Golden Path with GeneCards custom track

Promoters for DCTN6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001389118 303 2801 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for DCTN6 Gene

Chromosome:
8
Start:
30,156,297 bp from pter
End:
30,183,640 bp from pter
Size:
27,344 bases
Orientation:
Plus strand

Genomic View for DCTN6 Gene

Genes around DCTN6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN6 Gene

Proteins for DCTN6 Gene

  • Protein details for DCTN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00399-DCTN6_HUMAN
    Recommended name:
    Dynactin subunit 6
    Protein Accession:
    O00399
    Secondary Accessions:
    • B2RAC1

    Protein attributes for DCTN6 Gene

    Size:
    190 amino acids
    Molecular mass:
    20747 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5. Interacts with PLK1.

    Three dimensional structures from OCA and Proteopedia for DCTN6 Gene

neXtProt entry for DCTN6 Gene

Post-translational modifications for DCTN6 Gene

  • Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCTN6 Gene

No data available for DME Specific Peptides for DCTN6 Gene

Domains & Families for DCTN6 Gene

Gene Families for DCTN6 Gene

Protein Domains for DCTN6 Gene

Suggested Antigen Peptide Sequences for DCTN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00399

UniProtKB/Swiss-Prot:

DCTN6_HUMAN :
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
Family:
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
genes like me logo Genes that share domains with DCTN6: view

Function for DCTN6 Gene

genes like me logo Genes that share phenotypes with DCTN6: view

Animal Model Products

miRNA for DCTN6 Gene

miRTarBase miRNAs that target DCTN6

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN6 Gene

Localization for DCTN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN6 Gene

Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTN6 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCTN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with DCTN6: view

Pathways & Interactions for DCTN6 Gene

genes like me logo Genes that share pathways with DCTN6: view

Gene Ontology (GO) - Biological Process for DCTN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DCTN6: view

No data available for SIGNOR curated interactions for DCTN6 Gene

Transcripts for DCTN6 Gene

Unigene Clusters for DCTN6 Gene

Dynactin 6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for DCTN6 Gene

GeneLoc Exon Structure for
DCTN6
ECgene alternative splicing isoforms for
DCTN6

Expression for DCTN6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCTN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCTN6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4) and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCTN6 Gene



Protein tissue co-expression partners for DCTN6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTN6 Gene:

DCTN6

SOURCE GeneReport for Unigene cluster for DCTN6 Gene:

Hs.158427

mRNA Expression by UniProt/SwissProt for DCTN6 Gene:

O00399-DCTN6_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DCTN6: view

No data available for mRNA differential expression in normal tissues for DCTN6 Gene

Orthologs for DCTN6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCTN6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN6 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia DCTN6 34 35
  • 92.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCTN6 35
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCTN6 34 35
  • 89.65 (n)
oppossum
(Monodelphis domestica)
Mammalia DCTN6 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dctn6 34 16 35
  • 86.49 (n)
rat
(Rattus norvegicus)
Mammalia Dctn6 34
  • 86.32 (n)
chicken
(Gallus gallus)
Aves DCTN6 34 35
  • 78.42 (n)
lizard
(Anolis carolinensis)
Reptilia DCTN6 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn6 34
  • 77.47 (n)
Str.15736 34
zebrafish
(Danio rerio)
Actinopterygii zgc:112102 34
  • 70.09 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12481 34
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Ce 34 35
  • 52.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006924 34
  • 51.36 (n)
worm
(Caenorhabditis elegans)
Secernentea dnc-6 34 35
  • 46.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
Species where no ortholog for DCTN6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN6 Gene

ENSEMBL:
Gene Tree for DCTN6 (if available)
TreeFam:
Gene Tree for DCTN6 (if available)

Paralogs for DCTN6 Gene

Pseudogenes.org Pseudogenes for DCTN6 Gene

genes like me logo Genes that share paralogs with DCTN6: view

No data available for Paralogs for DCTN6 Gene

Variants for DCTN6 Gene

Sequence variations from dbSNP and Humsavar for DCTN6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10095115 -- 30,170,794(+) CGCCA(C/T)AATGC intron-variant
rs10096097 -- 30,169,582(+) GGAGC(A/G)CCAGG intron-variant
rs1047295 -- 30,156,319(+) CCAAT(A/C)GCATG utr-variant-5-prime
rs1047296 -- 30,156,360(+) TCGAT(C/T)TACGT utr-variant-5-prime
rs10503862 -- 30,158,242(+) ATGCT(C/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN6 Gene

Variant ID Type Subtype PubMed ID
nsv831277 CNV gain 17160897
nsv6139 CNV deletion 18451855
nsv1019816 CNV gain 25217958

Variation tolerance for DCTN6 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTN6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCTN6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN6 Gene

Disorders for DCTN6 Gene

Relevant External Links for DCTN6

Genetic Association Database (GAD)
DCTN6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTN6

No disorders were found for DCTN6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTN6 Gene

Publications for DCTN6 Gene

  1. Cloning and characterization of a novel gene, WS-3, in human chromosome 8p11-p12. (PMID: 9168138) Ichikawa K. … Furuichi Y. (Gene 1997) 2 3 4 22 64
  2. Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. (PMID: 23455152) Yeh T.Y. … Schroer T.A. (EMBO J. 2013) 3 4 64
  3. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PMID: 15043994) Parisi G. … Echave J. (FEBS Lett. 2004) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for DCTN6 Gene

Sources for DCTN6 Gene

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