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Aliases for DCTN6 Gene

Aliases for DCTN6 Gene

  • Dynactin 6 2 3
  • WS3 3 4 6
  • Dynactin Subunit P27 3 4
  • Protein WS-3 3 4
  • P27 3 6
  • Novel RGD-Containing Protein 3
  • Dynactin Subunit 6 3
  • WS-3 3

External Ids for DCTN6 Gene

Summaries for DCTN6 Gene

Entrez Gene Summary for DCTN6 Gene

  • The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCTN6 Gene

DCTN6 (Dynactin 6) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Vasopressin-regulated water reabsorption. GO annotations related to this gene include dynein binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN6 Gene

Genomics for DCTN6 Gene

Genomic Location for DCTN6 Gene

Start:
30,156,297 bp from pter
End:
30,183,640 bp from pter
Size:
27,344 bases
Orientation:
Plus strand

Genomic View for DCTN6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCTN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN6 Gene

Regulatory Elements for DCTN6 Gene

Proteins for DCTN6 Gene

  • Protein details for DCTN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00399-DCTN6_HUMAN
    Recommended name:
    Dynactin subunit 6
    Protein Accession:
    O00399
    Secondary Accessions:
    • B2RAC1

    Protein attributes for DCTN6 Gene

    Size:
    190 amino acids
    Molecular mass:
    20747 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5. Interacts with PLK1.

    Three dimensional structures from OCA and Proteopedia for DCTN6 Gene

neXtProt entry for DCTN6 Gene

Proteomics data for DCTN6 Gene at MOPED

Post-translational modifications for DCTN6 Gene

  • Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCTN6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DCTN6 Gene

Domains for DCTN6 Gene

Protein Domains for DCTN6 Gene

UniProtKB/Swiss-Prot:

DCTN6_HUMAN
Family:
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.:
    • O00399
genes like me logo Genes that share domains with DCTN6: view

No data available for Gene Families for DCTN6 Gene

Function for DCTN6 Gene

Gene Ontology (GO) - Molecular Function for DCTN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045502 dynein binding IEA --
genes like me logo Genes that share ontologies with DCTN6: view

Phenotypes for DCTN6 Gene

GenomeRNAi human phenotypes for DCTN6:
genes like me logo Genes that share phenotypes with DCTN6: view

miRNA for DCTN6 Gene

miRTarBase miRNAs that target DCTN6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCTN6 Gene

Localization for DCTN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN6 Gene

Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTN6 Gene COMPARTMENTS Subcellular localization image for DCTN6 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3
plasma membrane 3
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCTN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005869 dynactin complex IEA --
genes like me logo Genes that share ontologies with DCTN6: view

Pathways for DCTN6 Gene

genes like me logo Genes that share pathways with DCTN6: view

Pathways by source for DCTN6 Gene

2 GeneGo (Thomson Reuters Life Sciences Research) pathways for DCTN6 Gene
2 Reactome pathways for DCTN6 Gene
1 KEGG pathway for DCTN6 Gene

Gene Ontology (GO) - Biological Process for DCTN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007052 mitotic spindle organization IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DCTN6: view

Transcripts for DCTN6 Gene

mRNA/cDNA for DCTN6 Gene

Unigene Clusters for DCTN6 Gene

Dynactin 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for DCTN6 Gene

GeneLoc Exon Structure for
DCTN6
ECgene alternative splicing isoforms for
DCTN6

Expression for DCTN6 Gene

mRNA expression in normal human tissues for DCTN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTN6 Gene

SOURCE GeneReport for Unigene cluster for DCTN6 Gene Hs.158427

mRNA Expression by UniProt/SwissProt for DCTN6 Gene

O00399-DCTN6_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with DCTN6: view

Orthologs for DCTN6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCTN6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN6 36
  • 99.82 (n)
  • 100 (a)
DCTN6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCTN6 36
  • 89.65 (n)
  • 97.37 (a)
DCTN6 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCTN6 36
  • 92.11 (n)
  • 97.89 (a)
DCTN6 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dctn6 36
  • 86.49 (n)
  • 96.32 (a)
Dctn6 16
Dctn6 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCTN6 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCTN6 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctn6 36
  • 86.32 (n)
  • 96.84 (a)
chicken
(Gallus gallus)
Aves DCTN6 36
  • 78.42 (n)
  • 93.16 (a)
DCTN6 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCTN6 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn6 36
  • 77.47 (n)
  • 86.26 (a)
Str.15736 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12481 36
zebrafish
(Danio rerio)
Actinopterygii zgc:112102 36
  • 70.09 (n)
  • 81.62 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006924 36
  • 51.36 (n)
  • 48.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Ce 36
  • 52.83 (n)
  • 48.54 (a)
l(2)37Ce 37
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dnc-6 36
  • 46.23 (n)
  • 37.5 (a)
dnc-6 37
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
OneToOne
Species with no ortholog for DCTN6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN6 Gene

ENSEMBL:
Gene Tree for DCTN6 (if available)
TreeFam:
Gene Tree for DCTN6 (if available)

Paralogs for DCTN6 Gene

Pseudogenes.org Pseudogenes for DCTN6 Gene

genes like me logo Genes that share paralogs with DCTN6: view

No data available for Paralogs for DCTN6 Gene

Variants for DCTN6 Gene

Sequence variations from dbSNP and Humsavar for DCTN6 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs994400 -- 30,171,425(-) AAATT(A/T)AAAAA intron-variant
rs1047295 -- 30,156,319(+) CCAAT(A/C)GCATG utr-variant-5-prime
rs1047296 -- 30,156,360(+) TCGAT(C/T)TACGT utr-variant-5-prime
rs1875704 -- 30,160,188(-) CTACA(A/T)TTCAA intron-variant
rs2134558 -- 30,157,085(-) GGGTT(C/T)GAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN6 Gene

Variant ID Type Subtype PubMed ID
nsv831277 CNV Gain 17160897
nsv6139 CNV Loss 18451855

Relevant External Links for DCTN6 Gene

HapMap Linkage Disequilibrium report
DCTN6

Disorders for DCTN6 Gene

(1) University of Copenhagen DISEASES for DCTN6 Gene

Relevant External Links for DCTN6

Genetic Association Database (GAD)
DCTN6
genes like me logo Genes that share disorders with DCTN6: view

No data available for UniProtKB/Swiss-Prot for DCTN6 Gene

Publications for DCTN6 Gene

  1. Cloning and characterization of a novel gene, WS-3, in human chromosome 8p11-p12. (PMID: 9168138) Ichikawa K. … Furuichi Y. (Gene 1997) 2 3 4 23
  2. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PMID: 15043994) Parisi G. … Echave J. (FEBS Lett. 2004) 3 23
  3. Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. (PMID: 23455152) Yeh T.Y. … Schroer T.A. (EMBO J. 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for DCTN6 Gene

Sources for DCTN6 Gene

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