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Aliases for DCTN5 Gene

Aliases for DCTN5 Gene

  • Dynactin Subunit 5 2 3 5
  • Dynactin Subunit P25 4
  • Dynactin 5 (P25) 2

External Ids for DCTN5 Gene

Previous GeneCards Identifiers for DCTN5 Gene

  • GC16P023561
  • GC16P021742

Summaries for DCTN5 Gene

Entrez Gene Summary for DCTN5 Gene

  • This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for DCTN5 Gene

DCTN5 (Dynactin Subunit 5) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Immune System.

Gene Wiki entry for DCTN5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN5 Gene

Genomics for DCTN5 Gene

Regulatory Elements for DCTN5 Gene

Enhancers for DCTN5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCTN5 on UCSC Golden Path with GeneCards custom track

Promoters for DCTN5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCTN5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCTN5 Gene

23,641,366 bp from pter
23,677,455 bp from pter
36,090 bases
Plus strand

Genomic View for DCTN5 Gene

Genes around DCTN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN5 Gene

Proteins for DCTN5 Gene

  • Protein details for DCTN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynactin subunit 5
    Protein Accession:
    Secondary Accessions:
    • A8K9X8
    • H3BN51
    • H3BQA4

    Protein attributes for DCTN5 Gene

    182 amino acids
    Molecular mass:
    20127 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.

    Alternative splice isoforms for DCTN5 Gene


neXtProt entry for DCTN5 Gene

Proteomics data for DCTN5 Gene at MOPED

Post-translational modifications for DCTN5 Gene

  • Ubiquitination at Lys 10, Lys 21, and Lys 175
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCTN5 Gene

Domains & Families for DCTN5 Gene

Gene Families for DCTN5 Gene

Protein Domains for DCTN5 Gene


Suggested Antigen Peptide Sequences for DCTN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
genes like me logo Genes that share domains with DCTN5: view

Function for DCTN5 Gene

genes like me logo Genes that share phenotypes with DCTN5: view

Animal Models for DCTN5 Gene

MGI Knock Outs for DCTN5:

Animal Model Products

miRNA for DCTN5 Gene

miRTarBase miRNAs that target DCTN5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCTN5 Gene

Localization for DCTN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN5 Gene

Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore.

Subcellular locations from

Jensen Localization Image for DCTN5 Gene COMPARTMENTS Subcellular localization image for DCTN5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
extracellular 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 21399614
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with DCTN5: view

Pathways & Interactions for DCTN5 Gene

genes like me logo Genes that share pathways with DCTN5: view

Gene Ontology (GO) - Biological Process for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060976 coronary vasculature development IEA --
genes like me logo Genes that share ontologies with DCTN5: view

No data available for SIGNOR curated interactions for DCTN5 Gene

Drugs & Compounds for DCTN5 Gene

No Compound Related Data Available

Transcripts for DCTN5 Gene

Unigene Clusters for DCTN5 Gene

Dynactin 5 (p25):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -

Relevant External Links for DCTN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCTN5 Gene

mRNA expression in normal human tissues for DCTN5 Gene

Protein differential expression in normal tissues from HIPED for DCTN5 Gene

This gene is overexpressed in Frontal cortex (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTN5 Gene

SOURCE GeneReport for Unigene cluster for DCTN5 Gene Hs.435941

genes like me logo Genes that share expression patterns with DCTN5: view

Protein tissue co-expression partners for DCTN5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTN5 Gene

Orthologs for DCTN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCTN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCTN5 35
  • 93.04 (n)
  • 99.45 (a)
MGC3248 36
  • 95 (a)
(Canis familiaris)
Mammalia DCTN5 35
  • 93.04 (n)
  • 100 (a)
DCTN5 36
  • 100 (a)
(Mus musculus)
Mammalia Dctn5 35
  • 92.12 (n)
  • 99.45 (a)
Dctn5 16
Dctn5 36
  • 99 (a)
(Pan troglodytes)
Mammalia DCTN5 35
  • 99.63 (n)
  • 100 (a)
DCTN5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dctn5 35
  • 92.45 (n)
  • 99.45 (a)
(Monodelphis domestica)
Mammalia DCTN5 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia DCTN5 36
  • 92 (a)
(Gallus gallus)
Aves DCTN5 35
  • 81.32 (n)
  • 98.35 (a)
DCTN5 36
  • 96 (a)
(Anolis carolinensis)
Reptilia DCTN5 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn5 35
  • 79.49 (n)
  • 96.15 (a)
Str.13717 35
(Danio rerio)
Actinopterygii dctn5 35
  • 78.94 (n)
  • 95.05 (a)
Dr.12983 35
dctn5 36
  • 96 (a)
fruit fly
(Drosophila melanogaster)
Insecta dyn-p25 35
  • 59.51 (n)
  • 60.45 (a)
dyn-p25 36
  • 57 (a)
(Caenorhabditis elegans)
Secernentea dnc-5 35
  • 53.56 (n)
  • 44.38 (a)
dnc-5 36
  • 43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7368 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07196 35
  • 54.33 (n)
  • 46.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
Species with no ortholog for DCTN5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN5 Gene

Gene Tree for DCTN5 (if available)
Gene Tree for DCTN5 (if available)

Paralogs for DCTN5 Gene Pseudogenes for DCTN5 Gene

genes like me logo Genes that share paralogs with DCTN5: view

No data available for Paralogs for DCTN5 Gene

Variants for DCTN5 Gene

Sequence variations from dbSNP and Humsavar for DCTN5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3863493 -- 23,671,310(-) AAAGT(A/C/G)CCTAA nc-transcript-variant, utr-variant-3-prime
rs7588 -- 23,669,844(+) ATAAA(A/G)AACCA nc-transcript-variant, utr-variant-3-prime
rs26760 -- 23,668,965(-) TCCCA(C/T)CACCT nc-transcript-variant, utr-variant-3-prime
rs34513 -- 23,660,671(-) AGAGA(C/G)AGAAC intron-variant
rs34514 -- 23,659,276(-) TTATT(C/T)CCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN5 Gene

Variant ID Type Subtype PubMed ID
esv2660866 CNV Deletion 23128226
esv2714093 CNV Deletion 23290073
nsv827603 CNV Loss 20364138
nsv819151 CNV Loss 19587683

Variation tolerance for DCTN5 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DCTN5 Gene

Disorders for DCTN5 Gene

Relevant External Links for DCTN5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCTN5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTN5 Gene

Publications for DCTN5 Gene

  1. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PMID: 15043994) Parisi G. … Echave J. (FEBS Lett. 2004) 2 3 23 67
  2. Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end. (PMID: 10525537) Eckley D.M. … Schroer T.A. (J. Cell Biol. 1999) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DCTN5 Gene

Sources for DCTN5 Gene