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DCTN5 Gene

protein-coding   GIFtS: 58
GCID: GC16P023652

Dynactin 5 (P25)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dynactin 5 (P25)1 2
Dynactin Subunit P252 3
Dynactin 42
Dynactin Subunit 52
p255

External Ids:    HGNC: 245941   Entrez Gene: 845162   Ensembl: ENSG000001668477   OMIM: 6129625   UniProtKB: Q9BTE13   
ORGUL members:         

Export aliases for DCTN5 gene to outside databases

Previous GC identifers: GC16P023561 GC16P021742


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCTN5 Gene:
This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in
minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to
bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jan
2011)

GeneCards Summary for DCTN5 Gene:
DCTN5 (dynactin 5 (p25)) is a protein-coding gene. Diseases associated with DCTN5 include breast cancer.

Gene Wiki entry for DCTN5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCTN5 gene promoter:
         CUTL1   Nkx5-1   HNF-3beta   NF-kappaB   FOXJ2 (long isoform)   HFH-1   NF-kappaB2   FOXJ2   LyF-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCTN5 promoter sequence
   Search Chromatin IP Primers for DCTN5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCTN5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.1

DCTN5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTN5 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P023652:  view genomic region     (about GC identifiers)

Start:
23,652,687 bp from pter      End:
23,685,068 bp from pter
Size:
32,382 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DCTN5_HUMAN, Q9BTE1 (See protein sequence)
Recommended Name: Dynactin subunit 5  
Size: 182 amino acids; 20127 Da
Subunit: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6
subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5
Secondary accessions: A8K9X8 H3BN51 H3BQA4
Alternative splicing: 3 isoforms:  Q9BTE1-1   Q9BTE1-2   Q9BTE1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCTN5: NX_Q9BTE1

Explore proteomics data for DCTN5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys175
  • Modification sites at PhosphoSitePlus

  • See DCTN5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001185940.1  NP_001186672.1  NP_115875.1  

    ENSEMBL proteins: 
     ENSP00000300087   ENSP00000454691   ENSP00000457585   ENSP00000456137   ENSP00000456483  
     ENSP00000455685   ENSP00000458354  
    Reactome Protein details: Q9BTE1

    DCTN5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DCTN5

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001451 Hexapep_transf
     IPR011004 Trimer_LpxA-like

    Graphical View of Domain Structure for InterPro Entry Q9BTE1

    ProtoNet protein and cluster: Q9BTE1

    UniProtKB/Swiss-Prot: DCTN5_HUMAN, Q9BTE1
    Similarity: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily


    DCTN5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dctn5):
     mortality/aging  vision/eye 

    DCTN5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCTN5
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCTN5

    miRNA
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    miRTarBase miRNAs that target DCTN5:
    hsa-mir-122-5p (MIRT023378), hsa-mir-375 (MIRT020007), hsa-mir-340-5p (MIRT019580), hsa-let-7c-5p (MIRT051842), hsa-mir-149-5p (MIRT045566), hsa-mir-193a-3p (MIRT044893), hsa-mir-484 (MIRT042338)

    Block miRNA regulation of human, mouse, rat DCTN5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCTN5 (see all 55):
    hsa-miR-124* hsa-miR-548j hsa-miR-3685 hsa-miR-3607-3p hsa-miR-146a hsa-miR-15a hsa-miR-503 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidDCTN5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DCTN5
    Predesigned siRNA for gene silencing in human, mouse, rat DCTN5

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    Sino Biological Human cDNA Clone for DCTN5
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCTN5_HUMAN, Q9BTE1: Cytoplasm, cytoskeleton (By similarity). Chromosome, centromere, kinetochore
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    extracellular2
    peroxisome2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--

    DCTN5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCTN5 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    2Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    3Vasopressin-regulated water reabsorption
    Vasopressin-regulated water reabsorption
    4MHC class II antigen presentation
    MHC class II antigen presentation
    5Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DCTN5
        Alzheimers Disease Pathway

    2 GeneGo (Thomson Reuters) Pathways for DCTN5
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments


    1 Reactome Pathway for DCTN5
        MHC class II antigen presentation


    1 Kegg Pathway  (Kegg details for DCTN5):
        Vasopressin-regulated water reabsorption


    DCTN5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCTN5
    Interactions:

        Search GeneGlobe Interaction Network for DCTN5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCTN5 (Q9BTE12, 3 ENSP000003000874) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NINLQ9Y2I62, 3, ENSP000002788864MINT-67032 I2D: score=5 STRING: ENSP00000278886
    DCTN6O003993, ENSP000002211144I2D: score=1 STRING: ENSP00000221114
    RPL17P186213I2D: score=1 
    UBE2L3P680363I2D: score=1 
    UTP23Q9BRU93I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    DCTN5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCTN5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCTN5 gene (3 alternative transcripts): 
    NM_001199011.1  NM_001199743.1  NM_032486.3  

    Unigene Cluster for DCTN5:

    Dynactin 5 (p25)
    Hs.435941  [show with all ESTs]
    Unigene Representative Sequence: NR_037573
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300087(uc021tfi.1 uc021tfj.1 uc002dly.2) ENST00000563998
    ENST00000566053 ENST00000568589 ENST00000563188 ENST00000568272(uc021tfh.1)
    ENST00000566298 ENST00000563614
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DCTN5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCTN5 (see all 55):
    hsa-miR-124* hsa-miR-548j hsa-miR-3685 hsa-miR-3607-3p hsa-miR-146a hsa-miR-15a hsa-miR-503 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidDCTN5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DCTN5
    Predesigned siRNA for gene silencing in human, mouse, rat DCTN5
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    GenScript: all cDNA clones in your preferred vector (see all 3): DCTN5 (NM_032486)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DCTN5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCTN5
      QuantiTect SYBR Green Assays in human, mouse, rat DCTN5
      QuantiFast Probe-based Assays in human, mouse, rat DCTN5

    Additional mRNA sequence: 

    AK022200.1 AK027387.1 AK126469.1 AK292843.1 AK299631.1 BC004191.2 NR_037573.1 

    18 DOTS entries:

    DT.100807766  DT.445595  DT.101983940  DT.211895  DT.40121682  DT.100667244  DT.113953  DT.120710959 
    DT.120710935  DT.120710981  DT.100807762  DT.120662373  DT.91743574  DT.91856619  DT.92431276  DT.100836722 
    DT.120710933  DT.120710961 

    Selected AceView cDNA sequences (see all 456):

    AI369441 AA749190 BU902147 BM836008 BF448066 AI694218 AI928790 CB110353 
    BE265406 BM561234 CK819746 BM918658 AA435708 BM719953 BQ672094 BU838439 
    BQ425600 BG681321 AI675643 AA992008 AA327014 BM995652 CR626741 BU507964 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCTN5 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
    SP1:                          -           -                             -     -                                 
    SP2:                          -           -                             -                                       
    SP3:                          -           -     -                       -     -                                 
    SP4:                          -           -                                                                     
    SP5:                                      -                                                                     


    ECgene alternative splicing isoforms for DCTN5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCTN5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCCACAGA
    DCTN5 Expression
    About this image

    DCTN5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCTN5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435941
        Custom PCR Arrays for DCTN5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DCTN5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dctn51 , 5 dynactin 51, 5 92.12(n)1
    99.45(a)1
      7 (65.47 cM)5
    592881  NM_021608.31  NP_067621.31 
     1221330415 
    chicken
    (Gallus gallus)
    Aves DCTN51 dynactin 5 (p25) 81.32(n)
    98.35(a)
      416574  NM_001198639.1  NP_001185568.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCTN56
    dynactin 5 (p25)
    79(a)
    1 ↔ 1
    GL343933.1(22775-29544)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.137172 Transcribed sequence with strong similarity to protein more 79.39(n)    BX738859.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.129832 Transcribed sequence with strong similarity to protein more 78.6(n)    CK398772.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dyn-p251 dynactin-subunit-p25 59.51(n)
    60.45(a)
      34873  NM_165097.4  NP_723893.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dnc-51 dnc-5 53.56(n)
    44.38(a)
      171856  NM_058664.3  NP_491065.1 


    ENSEMBL Gene Tree for DCTN5 (if available)
    TreeFam Gene Tree for DCTN5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCTN5 gene
    Selected SIMAP similar genes for DCTN5 using alignment to 5 protein entries:     DCTN5_HUMAN (see all proteins) (see all similar genes):
    DNMT1    EML2    FOPNL    RTBDN    CHID1    PLA2G6
    AURA2    BTBD2    RNF217    TMEM44    APOD    FAM210A
    HECW1    UTY    FKBP3    PLEKHH2    SHANK2    ZNF20

    DCTN5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DCTN5
    PGOHUM00000245074


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCTN5 (see all 581)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414465541,2
    C--21740399(+) GTGAAA/CTCCTG 4 -- us2k10--------
    rs80503081,2
    C,F,H--23654923(+) TTTTAT/CGATAT 4 -- int19Minor allele frequency- C:0.09NS EA NA WA CSA 660
    rs1424403781,2
    --23654945(+) AACTAC/TTGGGC 4 -- int10--------
    rs2021351821,2
    C--23655003(+) TACTT-/AATAAA 4 -- int10--------
    rs80492501,2
    C,F,A,H--23655054(+) AAACTC/GTTAAA 4 -- int19Minor allele frequency- G:0.07NS EA WA CSA NA 653
    rs1925695861,2
    --23655200(+) ACAGGG/TTATAT 4 -- int10--------
    rs1844206571,2
    --23655322(+) AGTCTC/TCTTAT 4 -- int10--------
    rs1509099691,2
    --23655370(+) TAGTCA/TCCATT 4 -- int10--------
    rs1394496061,2
    --23655446(+) CTGTTC/TCTTTT 4 -- int10--------
    rs80502761,2
    C,F--23655464(+) tttttG/Tttgag 4 -- int13Minor allele frequency- T:0.20CSA WA 122

    HapMap Linkage Disequilibrium report for DCTN5 (23652687 - 23685068 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DCTN5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2714093CNV Deletion23290073
    esv2660866CNV Deletion23128226
    nsv827603CNV Loss20364138
    nsv819151CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612962    OMIM disorders: --

    1 disease for DCTN5:    
    About MalaCards
    breast cancer


    DCTN5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DCTN5
    Human Genome Epidemiology (HuGE) Navigator: DCTN5 (2 documents)

    Export disorders for DCTN5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCTN5 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with DCTN5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PubMed id 15043994)1, 3, 9 Parisi G....Echave J. (FEBS Lett. 2004)
    2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    3. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4 (Nature 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end. (PubMed id 10525537)1, 3 Eckley D.M....Schroer T.A. (J. Cell Biol. 1999)
    7. Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. (PubMed id 23455152)2 Yeh T.Y....Schroer T.A. (EMBO J. 2013)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84516 HGNC: 24594 AceView: MGC3248 Ensembl:ENSG00000166847 euGenes: HUgn84516
    ECgene: DCTN5 Kegg: 84516 H-InvDB: DCTN5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCTN5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DCTN5 gene:
    Search GeneIP for patents involving DCTN5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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