DCTN5 Gene
protein-coding GIFtS: 56
GCID: GC16P023652
|
|
dynactin 5 (p25)
| |
Aliases for DCTN5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Dynactin 5 (P25)1 2 | | Dynactin Subunit P252 3 | | P251 | | MGC32481 | | Dynactin 42 | | Dynactin Subunit 52 |
Export aliases for DCTN5 gene to outside databasesPrevious GC identifers: GC16P023561 GC16P021742 |
Summaries for DCTN5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DCTN5: This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved inminus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bindmembranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively splicedtranscript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jan 2011) Gene Wiki entry for DCTN5
|
Genomic Views for DCTN5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DCTN5 gene promoter: CUTL1 Nkx5-1 HNF-3beta NF-kappaB FOXJ2 (long isoform) HFH-1 NF-kappaB2 FOXJ2 LyF-1 NF-kappaB1 Other transcription factors
Search SABiosciences Chromatin IP Primers for DCTN5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCTN5 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p12.2 Ensembl cytogenetic band: 16p12.2 HGNC cytogenetic band: 16p12.1DCTN5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P023652: view genomic region
(about GC identifiers)
Start:
|
23,652,713 bp from pter |
End:
|
23,681,195 bp from pter |
Size:
|
28,483 bases |
Orientation:
|
plus strand |
|
Proteins for DCTN5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DCTN5_HUMAN, Q9BTE1 (See
protein sequence)Recommended Name: Dynactin subunit 5 Size: 182 amino acids; 20127 Da
Subunit: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6subunits and ACTR10 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: A8K9X8 H3BN51Alternative splicing: 2 isoforms: Q9BTE1-1 Q9BTE1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DCTN5: NX_Q9BTE1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BTE1 DCTN5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001185940.1 NP_001186672.1 NP_115875.1 ENSEMBL proteins: ENSP00000300087 ENSP00000454691 ENSP00000457585 ENSP00000456137 ENSP00000456483 ENSP00000455685 ENSP00000458354 Reactome Protein details: Q9BTE1 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
DCTN5 for ontologies About GeneDecksing
DCTN5 Antibody Products: Assay Products for DCTN5: |
Protein
Domains / Families for DCTN5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCTN5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BTE1ProtoNet protein and cluster: Q9BTE1 UniProtKB/Swiss-Prot: DCTN5_HUMAN, Q9BTE1Similarity: Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily |
Function for DCTN5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): DCTN5 (NM_032486) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCTN5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN5  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016740 | transferase activity |
IEA | -- |
DCTN5 for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Dctn5):
DCTN5 for phenotypes About GeneDecksing
|
Pathways & Interactions for DCTN5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cytoskeleton remodeling Neurofilaments | | | 2 | Cell cycle_Spindle assembly and chromosome separation | | | 3 | Immune System | | | 4 | MHC class II antigen presentation | | | 5 | Vasopressin-regulated water reabsorption | |
Pathway sources See GeneCards unified pathways Show all pathways
3 EMD Millipore Pathways for DCTN5
2 GeneGo (Thomson Reuters) Pathways for DCTN5 4
Reactome Pathways for DCTN5
1
Kegg Pathway (Kegg details for DCTN5):
DCTN5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCTN5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
 5/27 Interacting proteins for DCTN5 (Q9BTE12, 3 ENSP000003000874) via UniProtKB, MINT, STRING, and/or I2D (see all 27)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
TAS | -- |
DCTN5 for ontologies About GeneDecksing
|
Drugs & Compounds for DCTN5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DCTN5 Search CenterWatch for drugs/clinical trials and news about DCTN5 
|
Transcripts for DCTN5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DCTN5 gene (3 alternative transcripts): NM_001199011.1 NM_001199743.1 NM_032486.3 Unigene Cluster for DCTN5: Dynactin 5 (p25) Hs.435941 [show with all ESTs]Unigene Representative Sequence: NR_0375738 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000300087(uc021tfi.1 uc021tfj.1 uc002dly.2) ENST00000563998 ENST00000566053 ENST00000568589 ENST00000563188 ENST00000568272(uc021tfh.1) ENST00000566298 ENST00000563614
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN5 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN5 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): DCTN5 (NM_032486) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCTN5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN5  |
Additional cDNA sequence: AK022200.1 AK027387.1 AK126469.1 AK292843.1 AK299631.1 BC004191.2 NR_037573.1 18 DOTS entries: DT.100807766 DT.445595 DT.101983940 DT.211895 DT.40121682 DT.100667244 DT.113953 DT.120710959 DT.120710935 DT.120710981 DT.100807762 DT.120662373 DT.91743574 DT.91856619 DT.92431276 DT.100836722 DT.120710933 DT.120710961 24/456 AceView cDNA sequences (see all 456): BE219037 BM470405 AW589816 BM726124 AI359969 NM_032486 BM141898 AI352058 AA811478 CF127114 CA449974 AA364116 BM263671 CB216635 AI433447 BX484783 AA872624 AI004592 BU629071 AI392904 AA846098 CF135934 BE253080 BE272069 GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DCTN5 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | |
| SP1: | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for DCTN5
|
Expression for DCTN5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCTN5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TACCCACAGA
About this image See DCTN5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DCTN5
SOURCE GeneReport for Unigene cluster: Hs.435941 SABiosciences Custom PCR Arrays for DCTN5
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCTN5 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCTN5 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCTN5 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCTN5 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN5 |
Orthologs for DCTN5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DCTN5 gene from 7/26 species (see all 26) About this table
ENSEMBL Gene Tree for DCTN5 (if available) TreeFam Gene Tree for DCTN5 (if available)  |
Paralogs for DCTN5 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for DCTN5 gene
18/57 SIMAP similar genes for DCTN5 using alignment to 6 protein entries: DCTN5_HUMAN (see all proteins)
(see all similar genes):DNMT1 EML2 FOPNL RTBDN CHID1 PLA2G6 AURA2 BTBD2 RNF217 TMEM44 APOD FAM210A HECW1 UTY ZDHHC20 FKBP3 PLEKHH2 SHANK2
DCTN5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for DCTN5 PGOHUM00000245074
|
Genomic Variants for DCTN5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 16 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for DCTN5 (23652713 - 23681195 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for DCTN5 1 CNV: 58757  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCTN5 |
|
Disorders
/ Diseases for DCTN5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DCTN5 for disorders About GeneDecksing
OMIM gene information: 612962
OMIM disorders: --
3 diseases for DCTN5: About MalaCardsmental disorders breast cancer malaria Human Genome Epidemiology (HuGE) Navigator: DCTN5 (2 documents) Export disorders for DCTN5 gene to outside databases
|
Publications for DCTN5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCTN5 gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with DCTN5) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PubMed id 15043994)1, 3, 9 Parisi G....Echave J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end. (PubMed id 10525537)1, 3 Eckley D.M....Schroer T.A. (1999)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
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External Searches for DCTN5 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DCTN5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCTN5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCTN5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DCTN5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCTN5 gene: Search GeneIP for patents involving DCTN5
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DCTN5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | DCTN5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN5 |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN5 |
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