Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCTN5 Gene

Aliases for DCTN5 Gene

  • Dynactin Subunit 5 2 3 5
  • Dynactin Subunit P25 4
  • Dynactin 5 (P25) 2

External Ids for DCTN5 Gene

Previous GeneCards Identifiers for DCTN5 Gene

  • GC16P023561
  • GC16P021742

Summaries for DCTN5 Gene

Entrez Gene Summary for DCTN5 Gene

  • This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for DCTN5 Gene

DCTN5 (Dynactin Subunit 5) is a Protein Coding gene. Diseases associated with DCTN5 include Polycystic Kidney Disease 4, With Or Without Hepatic Disease. Among its related pathways are Golgi-to-ER retrograde transport and MHC class II antigen presentation.

Gene Wiki entry for DCTN5 Gene

Additional gene information for DCTN5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN5 Gene

Genomics for DCTN5 Gene

Regulatory Elements for DCTN5 Gene

Enhancers for DCTN5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H023667 1 ENCODE 91 +27.8 27782 4.1 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 FOS ATF7 DCTN5 PALB2 ENSG00000260482 PIR46977
GH16H023639 1.1 ENCODE 76.6 0.0 -10 3.2 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143 DCTN5 ENSG00000260751 RBBP6 PALB2 ENSG00000261723
GH16H023536 1.5 Ensembl ENCODE dbSUPER 31.3 -102.1 -102083 4.8 PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 TCF12 SLC30A9 FOS DCTN5 COG7 NDUFAB1 PALB2 GGA2 SUB1P4 GC16M023544
GH16H023503 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -135.8 -135750 4 HDGF PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 ZNF766 GLIS2 GATA2 ATF7 DCTN5 COG7 UBFD1 GGA2 PRKCB LOC100419017 PIR42085
GH16H023690 0.5 ENCODE 59.2 +50.0 50030 1.3 SCRT1 POLR2A KLF9 MAFK ZKSCAN1 DCTN5 ERN2 PALB2 GC16M023689 ENSG00000261266
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCTN5 on UCSC Golden Path with GeneCards custom track

Promoters for DCTN5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000084571 34 2001 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 ZNF143

Genomic Locations for DCTN5 Gene

Genomic Locations for DCTN5 Gene
36,090 bases
Plus strand

Genomic View for DCTN5 Gene

Genes around DCTN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN5 Gene

Proteins for DCTN5 Gene

  • Protein details for DCTN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynactin subunit 5
    Protein Accession:
    Secondary Accessions:
    • A8K9X8
    • H3BN51
    • H3BQA4

    Protein attributes for DCTN5 Gene

    182 amino acids
    Molecular mass:
    20127 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.

    Alternative splice isoforms for DCTN5 Gene


neXtProt entry for DCTN5 Gene

Post-translational modifications for DCTN5 Gene

  • Ubiquitination at isoforms=2, 310, isoforms=2, 321, and posLast=175175
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCTN5 Gene

Domains & Families for DCTN5 Gene

Gene Families for DCTN5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCTN5 Gene


Suggested Antigen Peptide Sequences for DCTN5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
genes like me logo Genes that share domains with DCTN5: view

Function for DCTN5 Gene

Gene Ontology (GO) - Molecular Function for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DCTN5: view
genes like me logo Genes that share phenotypes with DCTN5: view

Animal Models for DCTN5 Gene

MGI Knock Outs for DCTN5:

Animal Model Products

CRISPR Products

miRNA for DCTN5 Gene

miRTarBase miRNAs that target DCTN5

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCTN5 Gene

Localization for DCTN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN5 Gene

Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTN5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 2
peroxisome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DCTN5: view

Pathways & Interactions for DCTN5 Gene

genes like me logo Genes that share pathways with DCTN5: view

Gene Ontology (GO) - Biological Process for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003281 ventricular septum development IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0035904 aorta development IEA --
GO:0060976 coronary vasculature development IEA --
genes like me logo Genes that share ontologies with DCTN5: view

No data available for SIGNOR curated interactions for DCTN5 Gene

Drugs & Compounds for DCTN5 Gene

No Compound Related Data Available

Transcripts for DCTN5 Gene

Unigene Clusters for DCTN5 Gene

Dynactin 5 (p25):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -

Relevant External Links for DCTN5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCTN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCTN5 Gene

Protein differential expression in normal tissues from HIPED for DCTN5 Gene

This gene is overexpressed in Frontal cortex (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCTN5 Gene

Protein tissue co-expression partners for DCTN5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTN5 Gene:


SOURCE GeneReport for Unigene cluster for DCTN5 Gene:


Evidence on tissue expression from TISSUES for DCTN5 Gene

  • Nervous system(4.4)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with DCTN5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTN5 Gene

Orthologs for DCTN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCTN5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCTN5 33 34
  • 99.63 (n)
(Bos Taurus)
Mammalia MGC3248 34
  • 95 (a)
DCTN5 33
  • 93.04 (n)
(Canis familiaris)
Mammalia DCTN5 33 34
  • 93.04 (n)
(Rattus norvegicus)
Mammalia Dctn5 33
  • 92.45 (n)
(Mus musculus)
Mammalia Dctn5 33 16 34
  • 92.12 (n)
(Ornithorhynchus anatinus)
Mammalia DCTN5 34
  • 92 (a)
(Monodelphis domestica)
Mammalia DCTN5 34
  • 80 (a)
(Gallus gallus)
Aves DCTN5 33 34
  • 81.32 (n)
(Anolis carolinensis)
Reptilia DCTN5 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn5 33
  • 79.49 (n)
Str.13717 33
(Danio rerio)
Actinopterygii dctn5 33 34
  • 78.94 (n)
Dr.12983 33
fruit fly
(Drosophila melanogaster)
Insecta dyn-p25 33 34
  • 59.51 (n)
(Caenorhabditis elegans)
Secernentea dnc-5 33 34
  • 53.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 78 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07196 33
  • 54.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7368 33
Species where no ortholog for DCTN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN5 Gene

Gene Tree for DCTN5 (if available)
Gene Tree for DCTN5 (if available)

Paralogs for DCTN5 Gene

No data available for Paralogs for DCTN5 Gene

Variants for DCTN5 Gene

Sequence variations from dbSNP and Humsavar for DCTN5 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs587776405 Pathogenic 23,641,110(-) GAAAA(A/G)GTGCC upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs587781662 Pathogenic 23,641,132(-) GCCCC(CG/T)CAGCT upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs730881884 Pathogenic 23,641,115(-) AGAAG(G/T)AAAAG upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime
rs876659063 Pathogenic 23,641,123(-) CTGTG(-/A)GGAGA upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs878855123 Pathogenic 23,641,151(-) TGGAC(G/T)AGCCT upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DCTN5 Gene

Variant ID Type Subtype PubMed ID
nsv827603 CNV loss 20364138
nsv819151 CNV loss 19587683
esv3638233 CNV loss 21293372
esv2714093 CNV deletion 23290073
esv2660866 CNV deletion 23128226

Variation tolerance for DCTN5 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTN5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN5 Gene

Disorders for DCTN5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCTN5 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search DCTN5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCTN5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DCTN5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCTN5 Gene

Publications for DCTN5 Gene

  1. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PMID: 15043994) Parisi G … Echave J (FEBS letters 2004) 2 3 22 60
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 45 60
  3. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PMID: 17554300) Wellcome Trust Case Control Consortium (Nature 2007) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for DCTN5 Gene

Sources for DCTN5 Gene

Loading form....