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Aliases for DCTN4 Gene

Aliases for DCTN4 Gene

  • Dynactin Subunit 4 2 3 5
  • Dynactin Subunit P62 3 4
  • Dynactin 4 (P62) 2 3
  • DYN4 3 4
  • Dynactin P62 Subunit 3
  • P62 3

External Ids for DCTN4 Gene

Previous GeneCards Identifiers for DCTN4 Gene

  • GC05M150157
  • GC05M150685
  • GC05M150116
  • GC05M150068
  • GC05M145234

Summaries for DCTN4 Gene

GeneCards Summary for DCTN4 Gene

DCTN4 (Dynactin Subunit 4) is a Protein Coding gene. Diseases associated with DCTN4 include cystic fibrosis. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot for DCTN4 Gene

  • Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN4 Gene

Genomics for DCTN4 Gene

Regulatory Elements for DCTN4 Gene

Promoters for DCTN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCTN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCTN4 Gene

Chromosome:
5
Start:
150,708,440 bp from pter
End:
150,759,109 bp from pter
Size:
50,670 bases
Orientation:
Minus strand

Genomic View for DCTN4 Gene

Genes around DCTN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN4 Gene

Proteins for DCTN4 Gene

  • Protein details for DCTN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJW0-DCTN4_HUMAN
    Recommended name:
    Dynactin subunit 4
    Protein Accession:
    Q9UJW0
    Secondary Accessions:
    • B3KWW0
    • D3DQH0
    • E5RGT5
    • Q8TAN8

    Protein attributes for DCTN4 Gene

    Size:
    460 amino acids
    Molecular mass:
    52337 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres (By similarity).

    Alternative splice isoforms for DCTN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTN4 Gene

Proteomics data for DCTN4 Gene at MOPED

Post-translational modifications for DCTN4 Gene

  • Ubiquitination at Lys 146 and Lys 181
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DCTN4 Gene

Domains & Families for DCTN4 Gene

Gene Families for DCTN4 Gene

Protein Domains for DCTN4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJW0

UniProtKB/Swiss-Prot:

DCTN4_HUMAN :
  • Belongs to the dynactin subunit 4 family.
Family:
  • Belongs to the dynactin subunit 4 family.
genes like me logo Genes that share domains with DCTN4: view

Function for DCTN4 Gene

Molecular function for DCTN4 Gene

UniProtKB/Swiss-Prot Function:
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
genes like me logo Genes that share phenotypes with DCTN4: view

Human Phenotype Ontology for DCTN4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN4 Gene

Localization for DCTN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN4 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTN4 Gene COMPARTMENTS Subcellular localization image for DCTN4 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for DCTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005869 dynactin complex IEA,IBA --
genes like me logo Genes that share ontologies with DCTN4: view

Pathways & Interactions for DCTN4 Gene

genes like me logo Genes that share pathways with DCTN4: view

Gene Ontology (GO) - Biological Process for DCTN4 Gene

None

No data available for SIGNOR curated interactions for DCTN4 Gene

Drugs & Compounds for DCTN4 Gene

No Compound Related Data Available

Transcripts for DCTN4 Gene

Unigene Clusters for DCTN4 Gene

Dynactin 4 (p62):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN4 Gene

No ASD Table

Relevant External Links for DCTN4 Gene

GeneLoc Exon Structure for
DCTN4
ECgene alternative splicing isoforms for
DCTN4

Expression for DCTN4 Gene

mRNA expression in normal human tissues for DCTN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCTN4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6) and Islet of Langerhans (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTN4 Gene



SOURCE GeneReport for Unigene cluster for DCTN4 Gene Hs.675564

genes like me logo Genes that share expression patterns with DCTN4: view

Protein tissue co-expression partners for DCTN4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTN4 Gene

Orthologs for DCTN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCTN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN4 36
  • 100 (a)
OneToOne
DCTN4 35
  • 99.71 (n)
  • 99.78 (a)
cow
(Bos Taurus)
Mammalia DCTN4 35
  • 94.28 (n)
  • 98.04 (a)
DCTN4 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCTN4 36
  • 97 (a)
OneToOne
DCTN4 35
  • 93.26 (n)
  • 98.7 (a)
mouse
(Mus musculus)
Mammalia Dctn4 16
Dctn4 36
  • 97 (a)
OneToOne
Dctn4 35
  • 89.64 (n)
  • 96.74 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia DCTN4 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctn4 35
  • 89.93 (n)
  • 96.74 (a)
chicken
(Gallus gallus)
Aves DCTN4 35
  • 80.22 (n)
  • 91.74 (a)
DCTN4 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCTN4 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn4 35
  • 76.09 (n)
  • 85.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6759 35
zebrafish
(Danio rerio)
Actinopterygii dctn4 36
  • 85 (a)
OneToOne
dctn4 35
  • 75.25 (n)
  • 85.59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000908 35
  • 53.18 (n)
  • 47.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12042 36
  • 35 (a)
OneToOne
CG12042 35
  • 50.81 (n)
  • 45.01 (a)
CG12042 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea dnc-4 35
  • 45.5 (n)
  • 33.15 (a)
dnc-4 36
  • 29 (a)
OneToOne
C26B2.1 37
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for DCTN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN4 Gene

ENSEMBL:
Gene Tree for DCTN4 (if available)
TreeFam:
Gene Tree for DCTN4 (if available)

Paralogs for DCTN4 Gene

(1) SIMAP similar genes for DCTN4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DCTN4: view

No data available for Paralogs for DCTN4 Gene

Variants for DCTN4 Gene

Sequence variations from dbSNP and Humsavar for DCTN4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs11954652 - 150,718,321(+) CACTC(A/C/G)AAGAG reference, missense
rs3733923 - 150,711,219(-) AGAAA(A/G)TGACC reference, missense
rs35772018 - 150,730,677(-) GCTCT(A/G)TCCTC reference, missense
rs11550931 - 150,753,581(-) AGCTT(A/C)CAGAT reference, missense, utr-variant-5-prime
rs252157 -- 150,717,352(-) GAATC(A/G)CTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN4 Gene

Variant ID Type Subtype PubMed ID
dgv1862e1 CNV Complex 17122850
nsv428129 CNV Loss 18775914
esv33898 CNV Loss 17666407
dgv1863e1 CNV Complex 17122850
nsv5066 CNV Loss 18451855
esv2730916 CNV Deletion 23290073

Variation tolerance for DCTN4 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.48; 88.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTN4 Gene

HapMap Linkage Disequilibrium report
DCTN4
Human Gene Mutation Database (HGMD)
DCTN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN4 Gene

Disorders for DCTN4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCTN4 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search DCTN4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCTN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTN4
genes like me logo Genes that share disorders with DCTN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCTN4 Gene

Publications for DCTN4 Gene

  1. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. (PMID: 16554302) Lim C.M. … La Fontaine S. (J. Biol. Chem. 2006) 2 3 4 23 67
  2. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PMID: 10843801) Boultwood J. … Wainscoat J.S. (Genomics 2000) 2 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for DCTN4 Gene

Sources for DCTN4 Gene

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