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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCTN4 Gene

protein-coding   GIFtS: 58
GCID: GC05M150068

Dynactin 4 (P62)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dynactin 4 (P62)1 2     Dynactin P62 Subunit2
Dynactin Subunit P622 3     Dynactin Subunit 42
DYN42     Dyn43
P622     

External Ids:    HGNC: 155181   Entrez Gene: 511642   Ensembl: ENSG000001329127   OMIM: 6147585   UniProtKB: Q9UJW03   

Export aliases for DCTN4 gene to outside databases

Previous GC identifers: GC05M150157 GC05M150685 GC05M150116 GC05M145234


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DCTN4 Gene: 
DCTN4 (dynactin 4 (p62)) is a protein-coding gene. Diseases associated with DCTN4 include becker muscular dystrophy, and muscular dystrophy, and among its related super-pathways are Cytoskeleton remodeling Neurofilaments and Immune System. GO annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0
Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping.
Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the
cortical cytoskeleton




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCTN4 gene promoter:
         AREB6   AhR   CREB   Zic1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCTN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCTN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31-q32   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q31-q32

DCTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTN4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150068:  view genomic region     (about GC identifiers)

Start:
150,088,002 bp from pter      End:
150,138,671 bp from pter
Size:
50,670 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0 (See protein sequence)
Recommended Name: Dynactin subunit 4  
Size: 460 amino acids; 52337 Da
Subunit: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6
subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but
not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at
costameres (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate
cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt
microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution,
suggesting that this polypeptide may be targeted to the nucleus at very high expression levels
Secondary accessions: B3KWW0 D3DQH0 E5RGT5 Q8TAN8
Alternative splicing: 3 isoforms:  Q9UJW0-1   Q9UJW0-2   Q9UJW0-3   

Explore the universe of human proteins at neXtProt for DCTN4: NX_Q9UJW0

Explore proteomics data for DCTN4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UJW0

  • DCTN4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCTN4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001129115.1  NP_001129116.1  NP_057305.1  

    ENSEMBL proteins: 
     ENSP00000416968   ENSP00000411251   ENSP00000414906   ENSP00000428987   ENSP00000430993  
     ENSP00000429489   ENSP00000430183   ENSP00000431042  
    Reactome Protein details: Q9UJW0
    Human Recombinant Protein Products for DCTN4: 
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    Novus Biologicals DCTN4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCTN4 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10671518
    GO:0005737cytoplasm TAS10671518
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005869dynactin complex IEA--

    DCTN4 for ontologies           About GeneDecksing



    DCTN4 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DCTN4 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008603 Dynactin_p62

    Graphical View of Domain Structure for InterPro Entry Q9UJW0

    ProtoNet protein and cluster: Q9UJW0

    UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0
    Similarity: Belongs to the dynactin subunit 4 family


    DCTN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCTN4_HUMAN, Q9UJW0
    Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping.
    Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the
    cortical cytoskeleton

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0047485protein N-terminus binding IPI16554302
         
    DCTN4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DCTN4:
     Increased S DNA content  Increased number of mitotic ce  Metaphase cells  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DCTN4 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCTN4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCTN4 

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate DCTN4 (see all 14):
    hsa-miR-323-3p hsa-miR-3910 hsa-miR-30c hsa-miR-3942-5p hsa-miR-30d hsa-miR-30a hsa-miR-649 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidDCTN4 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DCTN4 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments0.91
    Cytoplasmic microtubules0.32
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Cell cycle Spindle assembly and chromosome separation
    Cell cycle Spindle assembly and chromosome separation0.94
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.47
    5MHC class II antigen presentation
    MHC class II antigen presentation0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for DCTN4
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for DCTN4
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments


    3        Reactome Pathways for DCTN4
        Adaptive Immune System
    Immune System
    MHC class II antigen presentation


    2         Kegg Pathways  (Kegg details for DCTN4):
        Vasopressin-regulated water reabsorption
    Huntington's disease


    DCTN4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for DCTN4 (Q9UJW01, 3 ENSP000004149064) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANK2Q014841, 3, ENSP000003495884EBI-2134033,EBI-941975 I2D: score=2 STRING: ENSP00000349588
    ACTR1AP611633, ENSP000003589214I2D: score=2 STRING: ENSP00000358921
    ATP7BP356703, ENSP000002428394I2D: score=2 STRING: ENSP00000242839
    DYNLL2Q96FJ23I2D: score=2 
    GYS1P138073I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    DCTN4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCTN4

    Search CenterWatch for drugs/clinical trials and news about DCTN4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCTN4 gene (3 alternative transcripts): 
    NM_001135643.1  NM_001135644.1  NM_016221.3  

    Unigene Cluster for DCTN4:

    Dynactin 4 (p62)
    Hs.675564  [show with all ESTs]
    Unigene Representative Sequence: NM_001135644
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447998(uc010jhi.3 uc003lsv.3 uc010jhj.2) ENST00000424236(uc003lsu.3 uc011dck.1)
    ENST00000446090 ENST00000518909 ENST00000522625 ENST00000521728 ENST00000519552
    ENST00000519313 ENST00000518015 ENST00000521448 ENST00000521533 ENST00000521093
    ENST00000520195 ENST00000517421
    miRNA
    Products:
         
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate DCTN4 (see all 14):
    hsa-miR-323-3p hsa-miR-3910 hsa-miR-30c hsa-miR-3942-5p hsa-miR-30d hsa-miR-30a hsa-miR-649 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidDCTN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DCTN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCTN4
    Clone
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    OriGene clones in human, mouse for DCTN4 (see all 15)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN4
    Sirion Biotech Customized lentivirus for stable overexpression of DCTN4 
                         Customized lentivirus expression plasmids for stable overexpression of DCTN4 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCTN4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCTN4

    Additional mRNA sequence: 

    AF156165.2 AF195120.1 AK000299.1 AK125973.1 AK296787.1 AK299517.1 AK307757.1 AK311693.1 
    AL162085.1 BC026323.1 

    17 DOTS entries:

    DT.416781  DT.99944395  DT.91771117  DT.95235369  DT.100788049  DT.101963558  DT.120818940  DT.100788047 
    DT.120818933  DT.91771115  DT.120818949  DT.100840837  DT.95156429  DT.120818977  DT.91771116  DT.91805447 
    DT.95311210 

    24/300 AceView cDNA sequences (see all 300):

    AW043971 T34752 BF445269 AK125973 AI623836 CA442898 BM791003 BF431187 
    BU674284 BE910748 CB269942 BX110237 BP381838 AI985898 BI964199 BE327767 
    CA942636 BU682754 AW028973 BM927713 AI873466 BG149433 BF056653 AA054471 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCTN4 expression in normal human tissues (normalized intensities)      DCTN4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATATTTGTG
    DCTN4 Expression
    About this image


    DCTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             retinal amacrine cell p0   
     
     Neural Tube (Nervous System)
             Rhombencephalon

    See DCTN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCTN4

    SOURCE GeneReport for Unigene cluster: Hs.675564
        SABiosciences Custom PCR Arrays for DCTN4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DCTN4 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dctn41 , 5 dynactin 41, 5 89.64(n)1
    96.74(a)1
      18 (34.36 cM)5
    676651  NM_026302.31  NP_080578.11 
     605262215 
    chicken
    (Gallus gallus)
    Aves DCTN41 dynactin 4 (p62) 80.37(n)
    91.86(a)
      416269  XM_003642061.1  XP_003642109.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCTN46
    Uncharacterized protein
    91(a)
    1 ↔ 1
    2(138409356-138443572)
    zebrafish
    (Danio rerio)
    Actinopterygii dctn41 dynactin 4 75.41(n)
    85.81(a)
      550479  NM_001017782.1  NP_001017782.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120421 , 3 microtubule-based movement3
    CG120421
    36(a)3
    50.81(n)1
    45.29(a)1
      43E93
    357091  NM_136467.31  NP_610311.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C26B2.13
    dnc-41
    Protein DNC-41 28(a)3
    45.28(n)1
    32.22(a)1
      IV(8018489-8019974)3
    1776001  NM_068943.31  NP_501344.11 


    ENSEMBL Gene Tree for DCTN4 (if available)
    TreeFam Gene Tree for DCTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCTN4 gene
    1 SIMAP similar gene for DCTN4 using alignment to 5 protein entries:     DCTN4_HUMAN (see all proteins):
    DKFZp761J032

    DCTN4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1200 SNPs in DCTN4 are shown (see all 1200)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2521581,2
    C,F,A,H--150087887(-) ACACTC/GAAGCT 3 -- ds500128Minor allele frequency- G:0.31NS EA NA WA CSA 2530
    rs754836111,2
    C,F--150087925(+) AAGAGT/CATGAA 3 -- ds50012Minor allele frequency- C:0.08WA EA 238
    rs104769411,2
    C,F,H--150088081(+) CTAACA/GACATT 3 -- ds500115Minor allele frequency- G:0.16NS EA NA CSA WA 1932
    rs100723651,2
    C,F,H--150088119(+) TAAGAA/CGCTCA 3 -- ds50014Minor allele frequency- C:0.01NS EA 418
    rs104767521,2
    F,H--150088140(+) TACTTA/GTATAT 3 -- ds50014Minor allele frequency- G:0.01NS EA 418
    rs783497541,2
    C,F--150088209(+) GCATGC/TCCCAC 3 -- ds50011Minor allele frequency- T:0.08EA 120
    rs1382124691,2
    --150088218(+) ACCAAC/TTCTCT 3 -- ds50010--------
    rs1870050281,2
    --150088491(+) AAAAGG/TTCAGT 3 -- ut310--------
    rs122321,2
    C,F--150088545(+) CCAAAG/ACTGTA 3 -- ut31 ese33Minor allele frequency- A:0.05MN WA EA 422
    rs121094811,2
    C,F,H--150088614(+) AATTTT/CTGCAC 3 -- ut319Minor allele frequency- C:0.05NS EA WA 1306

    HapMap Linkage Disequilibrium report for DCTN4 (150088002 - 150138671 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DCTN4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2730916CNV Deletion23290073
    nsv5066CNV Loss18451855
    nsv428129CNV Loss18775914
    esv33898CNV Loss17666407
    dgv1863e1CNV Complex17122850
    dgv1862e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): DCTN4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614758    OMIM disorders: --

    4 diseases for DCTN4:    About MalaCards
    becker muscular dystrophy    muscular dystrophy    huntington's disease    cystic fibrosis


    DCTN4 for disorders           About GeneDecksing


    Export disorders for DCTN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCTN4 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with DCTN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. (PubMed id 16554302)1, 2, 3, 9 Lim C.M....La Fontaine S. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PubMed id 10843801)1, 3 Boultwood J.... Wainscoat J.S. (2000)
    5. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. (PubMed id 10671518)1, 2 Karki S.... Holzbaur E.L.F. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Exome sequencing of extreme phenotypes identifies DCTN 4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. (PubMed id 22772370)1 Emond M.J....Bamshad M.J. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51164 HGNC: 15518 AceView: DCTN4 Ensembl:ENSG00000132912 euGenes: HUgn51164
    ECgene: DCTN4 Kegg: 51164 H-InvDB: DCTN4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCTN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCTN4 gene:
    Search GeneIP for patents involving DCTN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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