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Aliases for DCTN4 Gene

Aliases for DCTN4 Gene

  • Dynactin Subunit 4 2 3 5
  • Dynactin Subunit P62 3 4
  • Dynactin 4 (P62) 2 3
  • DYN4 3 4
  • Dynactin P62 Subunit 3
  • P62 3

External Ids for DCTN4 Gene

Previous GeneCards Identifiers for DCTN4 Gene

  • GC05M150157
  • GC05M150685
  • GC05M150116
  • GC05M150068
  • GC05M145234

Summaries for DCTN4 Gene

GeneCards Summary for DCTN4 Gene

DCTN4 (Dynactin Subunit 4) is a Protein Coding gene. Diseases associated with DCTN4 include Cystic Fibrosis. Among its related pathways are Golgi-to-ER retrograde transport and MHC class II antigen presentation. GO annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot for DCTN4 Gene

  • Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

Additional gene information for DCTN4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN4 Gene

Genomics for DCTN4 Gene

Regulatory Elements for DCTN4 Gene

Enhancers for DCTN4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H150788 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -31.0 -30982 3 BCOR TBL1XR1 JUN ZMYM3 EBF1 BATF FOSL1 EGR1 POLR2A EED ZNF300P1 DCTN4 TNIP1 RBM22 SMIM3 CCDC69 CD74 IRGM
GH05H150800 1.4 Ensembl ENCODE dbSUPER 11.8 -42.3 -42292 1 HDAC1 ATF1 ARNT ZFP64 ZBTB40 RAD21 ZNF366 ZNF143 ATF7 CREM SMIM3 DCTN4 RPS20P4 IRGM
GH05H150846 1.2 Ensembl ENCODE 11.5 -88.0 -87996 1 ATF1 ARID4B SIN3A ZNF2 ZNF143 ATF7 RUNX3 JUNB REST ZNF592 ZNF300P1 SMIM3 DCTN4 GPX3 IRGM ZNF300
GH05H150734 1 Ensembl ENCODE 12.2 +24.2 24217 1 CTCF PKNOX1 NFIB BACH1 EBF1 ZBTB40 BATF CHAMP1 YY1 CC2D1A DCTN4 SMIM3 RBM22 RPL7P1 RPS14 PIR34076
GH05H150699 1.1 ENCODE 11 +58.5 58458 2 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 ENSG00000250309 MYOZ3 RBM22 DCTN4 SMIM3 HMGXB3 ENSG00000253852 SYNPO RPS14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCTN4 on UCSC Golden Path with GeneCards custom track

Promoters for DCTN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189038 609 1801 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for DCTN4 Gene

Chromosome:
5
Start:
150,708,440 bp from pter
End:
150,759,109 bp from pter
Size:
50,670 bases
Orientation:
Minus strand

Genomic View for DCTN4 Gene

Genes around DCTN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN4 Gene

Proteins for DCTN4 Gene

  • Protein details for DCTN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJW0-DCTN4_HUMAN
    Recommended name:
    Dynactin subunit 4
    Protein Accession:
    Q9UJW0
    Secondary Accessions:
    • B3KWW0
    • D3DQH0
    • E5RGT5
    • Q8TAN8

    Protein attributes for DCTN4 Gene

    Size:
    460 amino acids
    Molecular mass:
    52337 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres (By similarity).

    Alternative splice isoforms for DCTN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTN4 Gene

Post-translational modifications for DCTN4 Gene

  • Ubiquitination at posLast=146146 and posLast=181181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCTN4 Gene

Domains & Families for DCTN4 Gene

Gene Families for DCTN4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCTN4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJW0

UniProtKB/Swiss-Prot:

DCTN4_HUMAN :
  • Belongs to the dynactin subunit 4 family.
Family:
  • Belongs to the dynactin subunit 4 family.
genes like me logo Genes that share domains with DCTN4: view

Function for DCTN4 Gene

Molecular function for DCTN4 Gene

UniProtKB/Swiss-Prot Function:
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

Phenotypes From GWAS Catalog for DCTN4 Gene

Gene Ontology (GO) - Molecular Function for DCTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0047485 protein N-terminus binding IPI 16554302
genes like me logo Genes that share ontologies with DCTN4: view
genes like me logo Genes that share phenotypes with DCTN4: view

Human Phenotype Ontology for DCTN4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCTN4
  • Applied Biological Materials Clones for DCTN4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN4 Gene

Localization for DCTN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN4 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTN4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000922 spindle pole IEA --
GO:0001725 stress fiber IEA --
GO:0005634 nucleus TAS 10671518
GO:0005737 cytoplasm TAS 10671518
genes like me logo Genes that share ontologies with DCTN4: view

Pathways & Interactions for DCTN4 Gene

genes like me logo Genes that share pathways with DCTN4: view

Gene Ontology (GO) - Biological Process for DCTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007097 nuclear migration IBA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DCTN4: view

No data available for SIGNOR curated interactions for DCTN4 Gene

Drugs & Compounds for DCTN4 Gene

No Compound Related Data Available

Transcripts for DCTN4 Gene

Unigene Clusters for DCTN4 Gene

Dynactin 4 (p62):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCTN4
  • Applied Biological Materials Clones for DCTN4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN4 Gene

No ASD Table

Relevant External Links for DCTN4 Gene

GeneLoc Exon Structure for
DCTN4
ECgene alternative splicing isoforms for
DCTN4

Expression for DCTN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCTN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCTN4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6) and Islet of Langerhans (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCTN4 Gene



Protein tissue co-expression partners for DCTN4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTN4 Gene:

DCTN4

SOURCE GeneReport for Unigene cluster for DCTN4 Gene:

Hs.675564

Evidence on tissue expression from TISSUES for DCTN4 Gene

  • Nervous system(5)
  • Lung(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTN4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • bronchus
  • heart
  • lung
Abdomen:
  • biliary tract
  • duodenum
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
Pelvis:
  • anus
  • rectum
  • testicle
General:
  • blood
  • blood vessel
  • coagulation system
  • skin
  • sweat gland
  • white blood cell
genes like me logo Genes that share expression patterns with DCTN4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTN4 Gene

Orthologs for DCTN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCTN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN4 33 34
  • 99.71 (n)
cow
(Bos Taurus)
Mammalia DCTN4 33 34
  • 94.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCTN4 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCTN4 33 34
  • 93.26 (n)
rat
(Rattus norvegicus)
Mammalia Dctn4 33
  • 89.93 (n)
mouse
(Mus musculus)
Mammalia Dctn4 33 16 34
  • 89.64 (n)
chicken
(Gallus gallus)
Aves DCTN4 33 34
  • 80.22 (n)
lizard
(Anolis carolinensis)
Reptilia DCTN4 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn4 33
  • 76.09 (n)
zebrafish
(Danio rerio)
Actinopterygii dctn4 33 34
  • 75.25 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6759 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000908 33
  • 53.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12042 35 33 34
  • 50.81 (n)
worm
(Caenorhabditis elegans)
Secernentea dnc-4 33 34
  • 45.5 (n)
C26B2.1 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for DCTN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN4 Gene

ENSEMBL:
Gene Tree for DCTN4 (if available)
TreeFam:
Gene Tree for DCTN4 (if available)

Paralogs for DCTN4 Gene

(1) SIMAP similar genes for DCTN4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DCTN4: view

No data available for Paralogs for DCTN4 Gene

Variants for DCTN4 Gene

Sequence variations from dbSNP and Humsavar for DCTN4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000094028 -- 150,730,157(+) GAAAG(C/T)TCTGT intron-variant
rs1000094136 -- 150,719,344(+) GAAGA(C/G)AAGGG intron-variant
rs1000180638 -- 150,747,022(+) CATGA(C/T)TGTAT intron-variant
rs1000287471 -- 150,758,307(+) TTACA(C/T)GACAT intron-variant, utr-variant-5-prime
rs1000293874 -- 150,753,421(+) TCTAT(-/G)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN4 Gene

Variant ID Type Subtype PubMed ID
esv2730916 CNV deletion 23290073
esv2759386 CNV loss 17122850
esv33898 CNV loss 17666407
nsv1128200 CNV deletion 24896259
nsv1137038 CNV deletion 24896259
nsv428129 CNV loss 18775914
nsv5066 CNV deletion 18451855

Variation tolerance for DCTN4 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.48; 88.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTN4 Gene

Human Gene Mutation Database (HGMD)
DCTN4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCTN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN4 Gene

Disorders for DCTN4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCTN4 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search DCTN4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCTN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTN4
genes like me logo Genes that share disorders with DCTN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCTN4 Gene

Publications for DCTN4 Gene

  1. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. (PMID: 16554302) Lim CM … La Fontaine S (The Journal of biological chemistry 2006) 2 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PMID: 10843801) Boultwood J … Wainscoat JS (Genomics 2000) 2 3 60
  5. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. (PMID: 10671518) Karki S … Holzbaur EL (The Journal of biological chemistry 2000) 3 4 60

Products for DCTN4 Gene

  • Addgene plasmids for DCTN4

Sources for DCTN4 Gene

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