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Aliases & Descriptions for DCTN4
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Descriptions Dynactin subunit p62 3 dynactin 4 (p62) 2 dynactin p62 subunit 2
Search outside databases for aliases for DCTN4 genePrevious GC identifers: GC05M150157 GC05M150685 GC05M150116
Summaries for DCTN4 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0 Function : Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactinpointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles inlinking dynein and dynactin to the cortical cytoskeleton
Genomic Location for DCTN4
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DCTN4 gene Entrez Gene cytogenetic band: 5q31-q32 Ensembl cytogenetic band: 5q33.1 HGNC cytogenetic band: 5q31-q32 DCTN4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M150068:
(about GC identifiers )
Start:
150,068,502 bp from pter
End:
150,118,769 bp from pter
Size:
50,268 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000005.8 NT_029289.10 Proteins for DCTN4
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0 (See
protein sequence )Recommended Name: Dynactin subunit 4 Size : 460 amino acids; 52337 Da
Subunit : Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4,DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit ofdynactin
Subcellular location : Cytoplasm, cytoskeleton. Centrosome. Note=Has a punctate cytoplasmicdistribution as well as centrosomal distribution typical of dynactin. Overexpression does notdisrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic andnuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very highexpression levels
Secondary accessions : Q8TAN8
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001129115.1 NP_001129116.1 NP_057305.1 ENSEMBL proteins: ENSP00000255263 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: DCTN4 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for DCTN4: Assays for DCTN4:
Protein
Domains/ Families for DCTN4(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UJW0 ProtoNet protein and cluster: Q9UJW0
UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0 Similarity : Belongs to the dynactin subunit 4 family
Gene Function for DCTN4
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_016221 Applied Biosystems Silencer ® siRNAs for DCTN4 Sigma-Aldrich siRNA for DCTN4 Sigma-Aldrich shRNA Panels and shRNA for DCTN4 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001135643                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001135643                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001135643  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001135643 UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0 Function : Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactinpointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles inlinking dynein and dynactin to the cortical cytoskeleton
1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for DCTN4
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Interacting proteins for DCTN4 (Q9UJW0 1 ENSP00000255263 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for DCTN4 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for DCTN4
Transcripts for DCTN4(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_016221 Sigma-Aldrich siRNA for DCTN4 Sigma-Aldrich shRNA Panels and shRNA for DCTN4 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001135643 NM_001135644 NM_016221
REFSEQ mRNAs for DCTN4 gene (3 alternative transcripts): NM_001135643.1 NM_001135644.1 NM_016221.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001135643 NM_001135644 NM_016221
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001135643                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001135643                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_001135643  
Additional cDNA sequence: AF156165.2 AF195120.1 AK000299.1 AK125973.1 AK296787.1 AK299517.1 AK307757.1 AK311693.1 AL162085.1 BC026323.1
17 DOTS entries : DT.416781 DT.99944395 DT.91771117 DT.95235369 DT.100788049 DT.101963558 DT.120818940 DT.100788047 DT.120818933 DT.91771115 DT.120818949 DT.100840837 DT.95156429 DT.120818977 DT.91771116 DT.91805447 DT.95311210
24/300 AceView cDNA sequences (see all 300
):AL162085 AA771783 AA352583 BG750279 AW089524 CA442898 AK125973 BE218028 AA054471 BG571610 BG149433 AW160363 T16286 AI873466 BI963887 AI276307 AW043971 BQ051358 BM927713 BF445266 BG253621 AI073775 AI985890 CA394492
highest scoring ESTs for DCTN4 :AA223368 AA323250 AA582253 AF195120 AK000299 AL597070 AL703548 AW015575 BC026323 BE885675
Unigene Cluster for DCTN4: Dynactin 4 (p62) Hs.675564 [show with all ESTs ] Unigene Representative Sequence: NM_001135644 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000255263
Expression for DCTN4
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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DCTN4 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DCTN4 1 / 2 / 3
7 probe-sets matching DCTN4 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CATATTTGTGSOURCE GeneReport for Unigene cluster: Hs.675564
Orthologs for DCTN4
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for DCTN4 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for DCTN4 ENSEMBL Gene Tree for DCTN4 Paralogs for DCTN4 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for DCTN4 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for DCTN4 (up to first 250kb)
Disorders & Mutations for DCTN4
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Medical News for DCTN4 (Possibly Related Articles in
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Publications for DCTN4 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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8 PubMed articles for DCTN4 gene : Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. (PubMed id 16554302) 1, 2, 3 Lim C.M....La Fontaine S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. (PubMed id 10671518) 3, 4 Karki S.... Holzbaur E.L.F. (2000) Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PubMed id 10843801) 2, 3 Boultwood J.... Wainscoat J.S. (2000) Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12730115) 7 Ross M.E....Downing J.R. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Self-regulated polymerization of the actin-related protein Arp1. (PubMed id 10074429) 3 Bingham J.B. and Schroer T.A. (1999)
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Specialized Databases showing DCTN4 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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