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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCTN4 Gene

protein-coding   GIFtS: 55
GCID: GC05M150068

dynactin 4 (p62)
 Explore 3 diseases affiliated with
DCTN4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DCTN4    

Aliases
for DCTN4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dynactin 4 (P62)1 2     Dynactin P62 Subunit2
Dynactin Subunit P622 3     Dynactin Subunit 42
DYN42     Dyn43
P622     

External Ids:    HGNC: 155181   Entrez Gene: 511642   Ensembl: ENSG000001329127   OMIM: 6147585   UniProtKB: Q9UJW03   

Export aliases for DCTN4 gene to outside databases

Previous GC identifers: GC05M150157 GC05M150685 GC05M150116 GC05M145234


Summaries
for DCTN4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0
Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could
be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical
cytoskeleton




Genomic Views
for DCTN4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCTN4 gene promoter:
         AREB6   AhR   CREB   Zic1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DCTN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCTN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31-q32   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q31-q32

DCTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTN4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150068:  view genomic region     (about GC identifiers)

Start:
 150,088,002 bp from pter      End:
 150,138,671 bp from pter
Size:
 50,670 bases      Orientation:
 minus strand

Proteins
for DCTN4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0 (See protein sequence)
Recommended Name: Dynactin subunit 4  
Size: 460 amino acids; 52337 Da
Subunit: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6
subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not
ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres
(By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Note=In skeletal muscles,
demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well
as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the
integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be
targeted to the nucleus at very high expression levels
Secondary accessions: B3KWW0 D3DQH0 E5RGT5 Q8TAN8
Alternative splicing: 3 isoforms:  Q9UJW0-1   Q9UJW0-2   Q9UJW0-3   

Explore the universe of human proteins at neXtProt for DCTN4: NX_Q9UJW0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UJW0

    • DCTN4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129115.1  NP_001129116.1  NP_057305.1  

    ENSEMBL proteins: 
     ENSP00000416968   ENSP00000411251   ENSP00000414906   ENSP00000428987   ENSP00000430993  
     ENSP00000429489   ENSP00000430183   ENSP00000431042  
    Reactome Protein details: Q9UJW0
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: DCTN4
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    Novus Biologicals DCTN4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DCTN4

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10671518
    GO:0005737cytoplasm TAS10671518
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--


    DCTN4 for ontologies           About GeneDecksing



    DCTN4 Antibody Products: 
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    Uscn ELISAs and CLIAs for DCTN4

    Protein Domains /
    Families
    for DCTN4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DCTN4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008603 Dynactin_p62

    Graphical View of Domain Structure for InterPro Entry Q9UJW0

    ProtoNet protein and cluster: Q9UJW0

    UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0
    Similarity: Belongs to the dynactin subunit 4 family


    Function
    for DCTN4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0
    Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could
    be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical
    cytoskeleton

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCTN4
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate DCTN4 (see all 14):
    hsa-miR-323-3p hsa-miR-3910 hsa-miR-30c hsa-miR-3942-5p hsa-miR-30d hsa-miR-30a hsa-miR-649 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: DCTN4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCTN4 (see all 7)
    OriGene shRNA RFP: DCTN4
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCTN4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DCTN4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN4 (see all 5)
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN4 

    Cell Line
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    Search LifeMap BioReagents cell lines for DCTN4

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN4

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0047485protein N-terminus binding IPI16554302


    DCTN4 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for DCTN4:
     Increased S DNA content  Increased number of mitotic ce  Metaphase cells  Synthetic lethal with Ras 


    Pathways & Interactions
    for DCTN4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeleton remodeling Neurofilaments
    		Cytoskeleton remodeling Neurofilaments1.00
    		Cytoplasmic microtubules0.32
    		Cytoskeleton remodeling_Neurofilaments0.91
    2Cell cycle_Spindle assembly and chromosome separation
    		Cell cycle_Spindle assembly and chromosome separation1.00
    		Cell cycle Spindle assembly and chromosome separation0.94
    3Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    4MHC class II antigen presentation
    		MHC class II antigen presentation1.00
    		Transport of antigen loaded MHC II molecules to surface0.59
    5Vasopressin-regulated water reabsorption
    		Vasopressin-regulated water reabsorption1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for DCTN4
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules


    2 GeneGo (Thomson Reuters) Pathways for DCTN4
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments

    4        Reactome Pathways for DCTN4
        Transport of antigen loaded MHC II molecules to surface
    Adaptive Immune System
    Immune System
    MHC class II antigen presentation


    2         Kegg Pathways  (Kegg details for DCTN4):
        Vasopressin-regulated water reabsorption
    Huntington's disease


    DCTN4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for DCTN4 (Q9UJW01, 3 ENSP000004149064) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANK2Q014841, 3, ENSP000003495884EBI-2134033,EBI-941975 I2D: score=2 STRING: ENSP00000349588
    ACTR1AP611633, ENSP000003589214I2D: score=2 STRING: ENSP00000358921
    ATP7BP356703, ENSP000002428394I2D: score=2 STRING: ENSP00000242839
    DYNLL2Q96FJ23I2D: score=2 
    GYS1P138073I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--


    DCTN4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DCTN4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCTN4
    Search CenterWatch for drugs/clinical trials and news about DCTN4 

    Transcripts
    for DCTN4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DCTN4 gene (3 alternative transcripts): 
    NM_001135643.1  NM_001135644.1  NM_016221.3  

    Unigene Cluster for DCTN4:

    Dynactin 4 (p62)
    Hs.675564  [show with all ESTs]
    Unigene Representative Sequence: NM_001135644
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447998(uc010jhi.3 uc003lsv.3 uc010jhj.2) ENST00000424236(uc003lsu.3 uc011dck.1)
    ENST00000446090 ENST00000518909 ENST00000522625 ENST00000521728 ENST00000519552
    ENST00000519313 ENST00000518015 ENST00000521448 ENST00000521533 ENST00000521093
    ENST00000520195 ENST00000517421

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCTN4
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate DCTN4 (see all 14):
    hsa-miR-323-3p hsa-miR-3910 hsa-miR-30c hsa-miR-3942-5p hsa-miR-30d hsa-miR-30a hsa-miR-649 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: DCTN4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCTN4 (see all 7)
    OriGene shRNA RFP: DCTN4
    OriGene siRNA: DCTN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCTN4
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): DCTN4 (NM_001135643)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCTN4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCTN4

    Additional cDNA sequence: 

    AF156165.2 AF195120.1 AK000299.1 AK125973.1 AK296787.1 AK299517.1 AK307757.1 AK311693.1 
    AL162085.1 BC026323.1 

    17 DOTS entries:

    DT.416781  DT.99944395  DT.91771117  DT.100788049  DT.95235369  DT.101963558  DT.120818940  DT.100788047 
    DT.120818933  DT.91771115  DT.120818949  DT.100840837  DT.95156429  DT.120818977  DT.91771116  DT.91805447 
    DT.95311210 

    24/300 AceView cDNA sequences (see all 300):

    BX110237 AI445159 CA942636 BG571610 AI276307 T34752 BM553566 CB269942 
    AI073775 BU682754 BF445269 BG149433 AA771783 CA445929 AL162085 AI697577 
    BQ051358 BE670352 AA776516 AW089524 BU674584 BF445266 AI623836 BF056653 

    GeneLoc Exon Structure


    Expression
    for DCTN4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCTN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATATTTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DCTN4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalHeart
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DCTN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCTN4

    SOURCE GeneReport for Unigene cluster: Hs.675564
        SABiosciences Custom PCR Arrays for DCTN4
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN4

    Orthologs
    for DCTN4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DCTN4 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dctn41 , 5 dynactin 41, 5 89.64(n)1
    96.74(a)1    		   18 (34.36 cM)5
    676651  NM_026302.31  NP_080578.11 
     605262215 
    chicken
    (Gallus gallus)    		 Aves DCTN41 dynactin 4 (p62) 80.37(n)
    91.86(a)    		   416269  XM_003642061.1  XP_003642109.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DCTN46
    		 --
    		 91(a)
    		 1 ↔ 1
    		 2(138409356-138443572)
    zebrafish
    (Danio rerio)    		 Actinopterygii dctn41 dynactin 4 75.41(n)
    85.81(a)    		   550479  NM_001017782.1  NP_001017782.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG120421 , 3 microtubule-based movement3
    CG120421    		 36(a)3
    50.81(n)1
    45.29(a)1    		   43E93
    357091  NM_136467.31  NP_610311.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C26B2.13
    dnc-41    		 Protein DNC-41 28(a)3
    45.28(n)1
    32.22(a)1    		   IV(8018489-8019974)3
    1776001  NM_068943.31  NP_501344.11 


    ENSEMBL Gene Tree for DCTN4 (if available)
    TreeFam Gene Tree for DCTN4 (if available) 

    Paralogs
    for DCTN4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DCTN4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/998 NCBI SNPs in DCTN4 are shown (see all 998)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2521581,2
    		C,F,A,H,--150087887(-) ACACTC/GAAGCT 3 -- ds500128Minor allele frequency- G:0.31NS EA NA WA CSA 2530
    rs754836111,2
    		F,--150087925(+) AAGAGT/CATGAA 3 -- ds50012Minor allele frequency- C:0.08WA EA 238
    rs104769411,2
    		C,F,H,--150088081(+) CTAACA/GACATT 3 -- ds500115Minor allele frequency- G:0.16NS EA NA CSA WA 1932
    rs100723651,2
    		C,F,H,--150088119(+) TAAGAA/CGCTCA 3 -- ds50014Minor allele frequency- C:0.01NS EA 418
    rs104767521,2
    		F,H,--150088140(+) TACTTA/GTATAT 3 -- ds50014Minor allele frequency- G:0.01NS EA 418
    rs783497541,2
    		F,--150088209(+) GCATGC/TCCCAC 3 -- ds50011Minor allele frequency- T:0.08EA 120
    rs1382124691,2
    		--150088218(+) ACCAAC/TTCTCT 3 -- ds50010--------
    rs1870050281,2
    		--150088491(+) AAAAGG/TTCAGT 3 -- ut310--------
    rs122321,2
    		F,--150088545(+) CCAAAG/ACTGTA 3 -- ut31 ese33Minor allele frequency- A:0.05MN WA EA 422
    rs121094811,2
    		C,F,H,--150088614(+) AATTTT/CTGCAC 3 -- ut319Minor allele frequency- C:0.05NS EA WA 1306

    HapMap Linkage Disequilibrium report for DCTN4 (150088002 - 150138671 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for DCTN4
         2 CNVs: 7477 3580
    Human Gene Mutation Database (HGMD): DCTN4

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    Disorders / Diseases
    for DCTN4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DCTN4 for disorders           About GeneDecksing

    OMIM gene information: 614758    OMIM disorders: --

    3 diseases for DCTN4:    About MalaCards
    becker muscular dystrophy    muscular dystrophy    huntington's disease


    Export disorders for DCTN4 gene to outside databases

    Publications
    for DCTN4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCTN4 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with DCTN4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. (PubMed id 16554302)1, 2, 3, 9 Lim C.M....La Fontaine S. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PubMed id 10843801)1, 3 Boultwood J.... Wainscoat J.S. (2000)
    5. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. (PubMed id 10671518)1, 2 Karki S.... Holzbaur E.L.F. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Exome sequencing of extreme phenotypes identifies DCTN 4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. (PubMed id 22772370)1 Emond M.J....Bamshad M.J. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for DCTN4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing DCTN4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51164 HGNC: 15518 AceView: DCTN4 Ensembl:ENSG00000132912 euGenes: HUgn51164
    ECgene: DCTN4 Kegg: 51164 H-InvDB: DCTN4

    Other Databases showing DCTN4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DCTN4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCTN4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DCTN4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DCTN4 gene:
    Search GeneIP for patents involving DCTN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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