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DCTN4 Gene

protein-coding   GIFtS: 56
GCID: GC05M150068

Dynactin 4 (P62)

  See DCTN4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynactin 4 (P62)1 2     Dynactin P62 Subunit2
Dynactin Subunit P622 3     Dynactin Subunit 42
DYN42 5     Dyn43
P622 5     

External Ids:    HGNC: 155181   Entrez Gene: 511642   Ensembl: ENSG000001329127   OMIM: 6147585   UniProtKB: Q9UJW03   

Export aliases for DCTN4 gene to outside databases

Previous GC identifers: GC05M150157 GC05M150685 GC05M150116 GC05M145234


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DCTN4 Gene:
DCTN4 (dynactin 4 (p62)) is a protein-coding gene. Diseases associated with DCTN4 include cystic fibrosis. GO annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0
Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping.
Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the
cortical cytoskeleton




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DCTN4 gene promoter:
         AREB6   AhR   CREB   Zic1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCTN4 promoter sequence
   Search Chromatin IP Primers for DCTN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31-q32   Ensembl cytogenetic band:  5q33.1   HGNC cytogenetic band: 5q31-q32

DCTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTN4 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M150068:  view genomic region     (about GC identifiers)

Start:
150,088,002 bp from pter      End:
150,138,671 bp from pter
Size:
50,670 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0 (See protein sequence)
Recommended Name: Dynactin subunit 4  
Size: 460 amino acids; 52337 Da
Subunit: Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6
subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but
not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at
costameres (By similarity)
Secondary accessions: B3KWW0 D3DQH0 E5RGT5 Q8TAN8
Alternative splicing: 3 isoforms:  Q9UJW0-1   Q9UJW0-2   Q9UJW0-3   

Explore the universe of human proteins at neXtProt for DCTN4: NX_Q9UJW0

Explore proteomics data for DCTN4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys146, Lys181
  • Modification sites at PhosphoSitePlus

  • See DCTN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129115.1  NP_001129116.1  NP_057305.1  

    ENSEMBL proteins: 
     ENSP00000416968   ENSP00000411251   ENSP00000414906   ENSP00000428987   ENSP00000430993  
     ENSP00000429489   ENSP00000430183   ENSP00000431042  
    Reactome Protein details: Q9UJW0

    DCTN4 Human Recombinant Protein Products:

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    Novus Biologicals DCTN4 Lysate
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    Cloud-Clone Corp. Proteins for DCTN4

     
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    antibodies-online proteins for DCTN4 (2 products) 

     
    antibodies-online peptides for DCTN4

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    antibodies-online antibodies for DCTN4 (27 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008603 Dynactin_p62

    Graphical View of Domain Structure for InterPro Entry Q9UJW0

    ProtoNet protein and cluster: Q9UJW0

    UniProtKB/Swiss-Prot: DCTN4_HUMAN, Q9UJW0
    Similarity: Belongs to the dynactin subunit 4 family


    Find genes that share domains with DCTN4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCTN4_HUMAN, Q9UJW0
    Function: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping.
    Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the
    cortical cytoskeleton

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0047485protein N-terminus binding IPI16554302
         
    Find genes that share ontologies with DCTN4           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DCTN4:
     Increased S DNA content  Increased number of mitotic ce  Metaphase cells  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DCTN4

    miRNA
    Products:
        
    miRTarBase miRNAs that target DCTN4:
    hsa-mir-142-3p (MIRT021605), hsa-mir-484 (MIRT042076), hsa-mir-93-5p (MIRT028163), hsa-mir-149-5p (MIRT045463), hsa-mir-378a-3p (MIRT043893)

    Block miRNA regulation of human, mouse, rat DCTN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCTN4 (see all 14):
    hsa-miR-323-3p hsa-miR-3910 hsa-miR-30c hsa-miR-3942-5p hsa-miR-30d hsa-miR-30a hsa-miR-649 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidDCTN4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DCTN4
    Predesigned siRNA for gene silencing in human, mouse, rat DCTN4

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for DCTN4
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    GenScript: all cDNA clones in your preferred vector (see all 3): DCTN4 (NM_001135643)
    Sino Biological Human cDNA Clone for DCTN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN4
    Addgene plasmids for DCTN4 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCTN4_HUMAN, Q9UJW0: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate
    cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt
    microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution,
    suggesting that this polypeptide may be targeted to the nucleus at very high expression levels
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS10671518
    GO:0005737cytoplasm TAS10671518
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005869dynactin complex IEA--

    Find genes that share ontologies with DCTN4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCTN4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    2Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    3Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    4Vasopressin-regulated water reabsorption
    Vasopressin-regulated water reabsorption
    5MHC class II antigen presentation
    MHC class II antigen presentation


    Find genes that share SuperPaths with DCTN4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DCTN4
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments


    1 Reactome Pathway for DCTN4
        MHC class II antigen presentation


    2 Kegg Pathways  (Kegg details for DCTN4):
        Vasopressin-regulated water reabsorption
    Huntington's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCTN4
    Interactions:

        Search GeneGlobe Interaction Network for DCTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCTN4 (Q9UJW01, 3 ENSP000004149064) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANK2Q014841, 3, ENSP000003495884EBI-2134033,EBI-941975 I2D: score=2 STRING: ENSP00000349588
    ACTR1AP611633, ENSP000003589214I2D: score=2 STRING: ENSP00000358921
    ATP7BP356703, ENSP000002428394I2D: score=2 STRING: ENSP00000242839
    DYNLL2Q96FJ23I2D: score=2 
    GYS1P138073I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with DCTN4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCTN4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCTN4 gene (3 alternative transcripts): 
    NM_001135643.1  NM_001135644.1  NM_016221.3  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447998(uc010jhi.3 uc003lsv.3 uc010jhj.2) ENST00000424236(uc003lsu.3 uc011dck.1)
    ENST00000446090 ENST00000518909 ENST00000522625 ENST00000521728 ENST00000519552
    ENST00000519313 ENST00000518015 ENST00000521448 ENST00000521533 ENST00000521093
    ENST00000520195 ENST00000517421
    miRNA
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    Block miRNA regulation of human, mouse, rat DCTN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCTN4 (see all 14):
    hsa-miR-323-3p hsa-miR-3910 hsa-miR-30c hsa-miR-3942-5p hsa-miR-30d hsa-miR-30a hsa-miR-649 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidDCTN4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): DCTN4 (NM_001135643)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN4
    Addgene plasmids for DCTN4 
    Primer
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    OriGene qPCR primer pairs and template standards for DCTN4
    OriGene qSTAR qPCR primer pairs in human, mouse for DCTN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCTN4
      QuantiTect SYBR Green Assays in human, mouse, rat DCTN4
      QuantiFast Probe-based Assays in human, mouse, rat DCTN4

    Selected AceView cDNA sequences (see all 300):

    BF445266 BI963887 BF448031 AW957298 BM927713 AW006744 CA445929 AI697577 
    BF445269 BI964199 AI985898 AI418169 BM698049 AK125973 BU155862 T34752 
    BU682754 BE327767 BG571610 AA776516 BM553566 BM724381 BF665991 CA394492 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCTN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATATTTGTG
    DCTN4 Expression
    About this image


    DCTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    DCTN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCTN4 Protein Expression
        Custom PCR Arrays for DCTN4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DCTN4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dctn41 , 5 dynactin 41, 5 89.64(n)1
    96.74(a)1
      18 (34.36 cM)5
    676651  NM_026302.31  NP_080578.11 
     605262215 
    chicken
    (Gallus gallus)
    Aves DCTN41 dynactin 4 (p62) 80.22(n)
    91.74(a)
      416269  XM_003642061.2  XP_003642109.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCTN46
    dynactin 4 (p62)
    91(a)
    1 ↔ 1
    2(138409356-138443572)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dctn41 dynactin 4 (p62) 76.09(n)
    85.87(a)
      595065  NM_001030502.1  NP_001025673.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dctn41 dynactin 4 75.25(n)
    85.59(a)
      550479  NM_001017782.1  NP_001017782.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG120421 , 3 microtubule-based movement3
    CG120421
    36(a)3
    50.81(n)1
    45.01(a)1
      43E93
    357091  NM_136467.31  NP_610311.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C26B2.13
    dnc-41
    dnc-41 28(a)3
    45.5(n)1
    33.15(a)1
      IV(8018489-8019974)3
    1776001  NM_068943.41  NP_501344.11 


    ENSEMBL Gene Tree for DCTN4 (if available)
    TreeFam Gene Tree for DCTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCTN4 gene
    1 SIMAP similar gene for DCTN4 using alignment to 5 protein entries:     DCTN4_HUMAN (see all proteins):
    DKFZp761J032

    Find genes that share paralogs with DCTN4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCTN4 (see all 1200)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2521581,2
    C,F,A,H--150087887(-) ACACTC/GAAGCT 3 -- ds500128Minor allele frequency- G:0.31NS EA NA WA CSA 2530
    rs754836111,2
    C,F--150087925(+) AAGAGT/CATGAA 3 -- ds50012Minor allele frequency- C:0.08WA EA 238
    rs104769411,2
    C,F,H--150088081(+) CTAACA/GACATT 3 -- ds500115Minor allele frequency- G:0.16NS EA NA CSA WA 1932
    rs100723651,2
    C,F,H--150088119(+) TAAGAA/CGCTCA 3 -- ds50014Minor allele frequency- C:0.01NS EA 418
    rs104767521,2
    F,H--150088140(+) TACTTA/GTATAT 3 -- ds50014Minor allele frequency- G:0.01NS EA 418
    rs783497541,2
    C,F--150088209(+) GCATGC/TCCCAC 3 -- ds50011Minor allele frequency- T:0.08EA 120
    rs1382124691,2
    --150088218(+) ACCAAC/TTCTCT 3 -- ds50010--------
    rs1870050281,2
    --150088491(+) AAAAGG/TTCAGT 3 -- ut310--------
    rs122321,2
    C,F--150088545(+) CCAAAG/ACTGTA 3 -- ut31 ese33Minor allele frequency- A:0.05MN WA EA 422
    rs121094811,2
    C,F,H--150088614(+) AATTTT/CTGCAC 3 -- ut319Minor allele frequency- C:0.05NS EA WA 1306

    HapMap Linkage Disequilibrium report for DCTN4 (150088002 - 150138671 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DCTN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730916CNV Deletion23290073
    nsv5066CNV Loss18451855
    nsv428129CNV Loss18775914
    esv33898CNV Loss17666407
    dgv1863e1CNV Complex17122850
    dgv1862e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): DCTN4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCTN4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614758    OMIM disorders: --

    1 disease for DCTN4:    
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    cystic fibrosis


    Find genes that share disorders with DCTN4           About GenesLikeMe


    Export disorders for DCTN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCTN4 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with DCTN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. (PubMed id 16554302)1, 2, 3, 9 Lim C.M.... La Fontaine S. (J. Biol. Chem. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PubMed id 10843801)1, 3 Boultwood J.... Wainscoat J.S. (Genomics 2000)
    5. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. (PubMed id 10671518)1, 2 Karki S.... Holzbaur E.L.F. (J. Biol. Chem. 2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis. (PubMed id 22772370)1 Emond M.J....Bamshad M.J. (Nat. Genet. 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51164 HGNC: 15518 AceView: DCTN4 Ensembl:ENSG00000132912 euGenes: HUgn51164
    ECgene: DCTN4 Kegg: 51164 H-InvDB: DCTN4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCTN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCTN4 gene:
    Search GeneIP for patents involving DCTN4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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