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Aliases for DCTN3 Gene

Aliases for DCTN3 Gene

  • Dynactin 3 (P22) 2 3
  • DCTN22 3 4 6
  • Dynactin Complex Subunit 22 KDa Subunit 3 4
  • Dynactin Light Chain 3
  • Dynactin Subunit 3 3
  • DCTN-22 3
  • P22 4

External Ids for DCTN3 Gene

Previous GeneCards Identifiers for DCTN3 Gene

  • GC09M034925
  • GC09M034782
  • GC09M034598
  • GC09M034603
  • GC09M034569

Summaries for DCTN3 Gene

Entrez Gene Summary for DCTN3 Gene

  • This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for DCTN3 Gene

DCTN3 (Dynactin 3 (P22)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for DCTN3 Gene

  • Together with dynein may be involved in spindle assembly and cytokinesis.

Gene Wiki entry for DCTN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN3 Gene

Genomics for DCTN3 Gene

Regulatory Elements for DCTN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCTN3 Gene

34,613,545 bp from pter
34,620,523 bp from pter
6,979 bases
Minus strand

Genomic View for DCTN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN3 Gene

Proteins for DCTN3 Gene

  • Protein details for DCTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynactin subunit 3
    Protein Accession:
    Secondary Accessions:
    • A6NII7
    • B2RBM5
    • Q5T1I5
    • Q5T1I7
    • Q5T8G3
    • Q9BPU8

    Protein attributes for DCTN3 Gene

    186 amino acids
    Molecular mass:
    21119 Da
    Quaternary structure:
    • Subunit of dynactin, a multiprotein complex associated with dynein
    • Sequence=CAI13144.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14178.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14180.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCTN3 Gene


neXtProt entry for DCTN3 Gene

Proteomics data for DCTN3 Gene at MOPED

Post-translational modifications for DCTN3 Gene

  • Ubiquitination at Lys50 and Lys156
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DCTN3 Gene

Domains for DCTN3 Gene

Protein Domains for DCTN3 Gene


Graphical View of Domain Structure for InterPro Entry



  • O75935
  • Belongs to the dynactin subunit 3 family.
genes like me logo Genes that share domains with DCTN3: view

No data available for Gene Families for DCTN3 Gene

Function for DCTN3 Gene

Molecular function for DCTN3 Gene

UniProtKB/Swiss-Prot Function:
Together with dynein may be involved in spindle assembly and cytokinesis.

Gene Ontology (GO) - Molecular Function for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 9722614
GO:0005515 protein binding IPI 9722614
genes like me logo Genes that share ontologies with DCTN3: view

Phenotypes for DCTN3 Gene

GenomeRNAi human phenotypes for DCTN3:
genes like me logo Genes that share phenotypes with DCTN3: view

miRNA for DCTN3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTN3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCTN3 Gene

Localization for DCTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN3 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.

Subcellular locations from

Jensen Localization Image for DCTN3 Gene COMPARTMENTS Subcellular localization image for DCTN3 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCTN3: view

Pathways for DCTN3 Gene

genes like me logo Genes that share pathways with DCTN3: view

Gene Ontology (GO) - Biological Process for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000910 cytokinesis IDA 9722614
GO:0006996 organelle organization TAS --
GO:0007017 microtubule-based process IEA --
genes like me logo Genes that share ontologies with DCTN3: view

Transcripts for DCTN3 Gene

Unigene Clusters for DCTN3 Gene

Dynactin 3 (p22):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTN3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - - -
SP11: -

Relevant External Links for DCTN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCTN3 Gene

mRNA expression in normal human tissues for DCTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DCTN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0) and Bone (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTN3 Gene

SOURCE GeneReport for Unigene cluster for DCTN3 Gene Hs.511768

mRNA Expression by UniProt/SwissProt for DCTN3 Gene

Tissue specificity: Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.
genes like me logo Genes that share expressions with DCTN3: view

Expression partners for DCTN3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DCTN3 Gene

Orthologs for DCTN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCTN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCTN3 35
  • 89.96 (n)
  • 94.09 (a)
DCTN3 36
  • 94 (a)
(Canis familiaris)
Mammalia DCTN3 35
  • 93.01 (n)
  • 94.62 (a)
DCTN3 36
  • 95 (a)
(Mus musculus)
Mammalia Dctn3 35
  • 89.61 (n)
  • 94.09 (a)
Dctn3 16
Dctn3 36
  • 94 (a)
(Pan troglodytes)
Mammalia DCTN3 35
  • 99.64 (n)
  • 100 (a)
DCTN3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dctn3 35
  • 89.61 (n)
  • 94.62 (a)
(Monodelphis domestica)
Mammalia DCTN3 36
  • 85 (a)
(Gallus gallus)
Aves DCTN3 35
  • 71.04 (n)
  • 69.4 (a)
DCTN3 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1847 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25551 35
(Danio rerio)
Actinopterygii dctn3 35
  • 59.52 (n)
  • 57.14 (a)
Dr.28565 35
dctn3 36
  • 55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.260 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2692 36
  • 31 (a)
Species with no ortholog for DCTN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCTN3 Gene

Gene Tree for DCTN3 (if available)
Gene Tree for DCTN3 (if available)

Paralogs for DCTN3 Gene

No data available for Paralogs for DCTN3 Gene

Variants for DCTN3 Gene

Sequence variations from dbSNP and Humsavar for DCTN3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3802427 -- 34,618,644(-) TGCCC(A/G)ACATC intron-variant
rs7864478 -- 34,620,900(+) actca(A/G)gctgt upstream-variant-2KB
rs7865283 -- 34,615,803(+) GAGGC(A/G)AGGTG intron-variant
rs10814127 -- 34,619,400(+) AAATA(A/G)TAATT intron-variant
rs10972167 -- 34,619,265(+) agggc(A/G)tacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN3 Gene

Variant ID Type Subtype PubMed ID
nsv831543 CNV Loss 17160897
nsv893038 CNV Loss 21882294
nsv818699 CNV Gain 17921354

Relevant External Links for DCTN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN3 Gene

Disorders for DCTN3 Gene

No disorders were found for DCTN3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DCTN3 Gene

Publications for DCTN3 Gene

  1. Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells. (PMID: 9722614) Karki S. … Holzbaur E.L.F. (J. Cell Biol. 1998) 2 3 4
  2. Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping. (PMID: 11306820) Mills D.R. … Jackson C.L. (Cytogenet. Cell Genet. 2001) 2 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DCTN3 Gene

Sources for DCTN3 Gene

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