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Aliases for DCTN3 Gene

Aliases for DCTN3 Gene

  • Dynactin Subunit 3 2 3 5
  • Dynactin Complex Subunit 22 KDa Subunit 3 4
  • Dynactin 3 (P22) 2 3
  • DCTN22 3 4
  • Dynactin Light Chain 3
  • DCTN-22 3
  • P22 4

External Ids for DCTN3 Gene

Previous GeneCards Identifiers for DCTN3 Gene

  • GC09M034925
  • GC09M034782
  • GC09M034598
  • GC09M034603
  • GC09M034569

Summaries for DCTN3 Gene

Entrez Gene Summary for DCTN3 Gene

  • This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for DCTN3 Gene

DCTN3 (Dynactin Subunit 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for DCTN3 Gene

  • Together with dynein may be involved in spindle assembly and cytokinesis.

Gene Wiki entry for DCTN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN3 Gene

Genomics for DCTN3 Gene

Regulatory Elements for DCTN3 Gene

Enhancers for DCTN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F034645 1 ENCODE 11.1 -26.8 -26751 2.6 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 GALT PIGO DCTN3 ENSG00000228352 SIGMAR1 ENSG00000258728 IL11RA
GH09F034575 1.3 FANTOM5 Ensembl ENCODE 10.4 +42.3 42296 5.1 ZNF263 CTCF RNF2 CBX2 REST ZFHX2 JUND ZNF366 POLR2A ZNF341 GALT RPP25L ENSG00000230074 ENHO FAM219A ENSG00000232983 ARID3C CNTFR ENSG00000230729 SIGMAR1
GH09F034573 0.2 ENCODE 10.4 +45.9 45921 1.8 GALT ENSG00000232983 RPP25L ENHO ENSG00000230729 DCTN3 ARID3C SIGMAR1 NUDT2 GC09P034579
GH09F034437 0.4 ENCODE 10.3 +183.0 182976 0.2 CTCF ZNF654 MAX TRIM22 MIER2 REST RAD21 ZNF692 ZNF143 SMC3 FAM219A NUDT2 ENSG00000230729 RPP25L ENHO ARID3C GALT SIGMAR1 DCTN3 DNAI1
GH09F034430 0.5 Ensembl ENCODE 10.3 +189.5 189507 0.4 KLF16 MIER1 GLIS1 SIN3A MIER2 REST DNAI1 FAM219A ENSG00000230729 RPP25L ENHO ARID3C GALT SIGMAR1 DCTN3 C9orf24
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DCTN3 on UCSC Golden Path with GeneCards custom track

Promoters for DCTN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001302660 123 1201 TBP HDAC1 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 BMI1 ZNF48

Genomic Location for DCTN3 Gene

Chromosome:
9
Start:
34,613,545 bp from pter
End:
34,620,523 bp from pter
Size:
6,979 bases
Orientation:
Minus strand

Genomic View for DCTN3 Gene

Genes around DCTN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN3 Gene

Proteins for DCTN3 Gene

  • Protein details for DCTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75935-DCTN3_HUMAN
    Recommended name:
    Dynactin subunit 3
    Protein Accession:
    O75935
    Secondary Accessions:
    • A6NII7
    • B2RBM5
    • Q5T1I5
    • Q5T1I7
    • Q5T8G3
    • Q9BPU8

    Protein attributes for DCTN3 Gene

    Size:
    186 amino acids
    Molecular mass:
    21119 Da
    Quaternary structure:
    • Subunit of dynactin, a multiprotein complex associated with dynein.
    SequenceCaution:
    • Sequence=CAI13144.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14178.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14180.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCTN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTN3 Gene

Post-translational modifications for DCTN3 Gene

  • Ubiquitination at Lys 50 and Lys 156
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCTN3 Gene

Domains & Families for DCTN3 Gene

Gene Families for DCTN3 Gene

Protein Domains for DCTN3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75935

UniProtKB/Swiss-Prot:

DCTN3_HUMAN :
  • Belongs to the dynactin subunit 3 family.
Family:
  • Belongs to the dynactin subunit 3 family.
genes like me logo Genes that share domains with DCTN3: view

Function for DCTN3 Gene

Molecular function for DCTN3 Gene

UniProtKB/Swiss-Prot Function:
Together with dynein may be involved in spindle assembly and cytokinesis.

Gene Ontology (GO) - Molecular Function for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 9722614
GO:0005515 protein binding IPI 9722614
genes like me logo Genes that share ontologies with DCTN3: view
genes like me logo Genes that share phenotypes with DCTN3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN3 Gene

Localization for DCTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN3 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTN3 Gene COMPARTMENTS Subcellular localization image for DCTN3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DCTN3: view

Pathways & Interactions for DCTN3 Gene

genes like me logo Genes that share pathways with DCTN3: view

Gene Ontology (GO) - Biological Process for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000910 cytokinesis IDA,TAS 9722614
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007017 microtubule-based process IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with DCTN3: view

No data available for SIGNOR curated interactions for DCTN3 Gene

Transcripts for DCTN3 Gene

Unigene Clusters for DCTN3 Gene

Dynactin 3 (p22):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - - -
SP10:
SP11: -

Relevant External Links for DCTN3 Gene

GeneLoc Exon Structure for
DCTN3
ECgene alternative splicing isoforms for
DCTN3

Expression for DCTN3 Gene

mRNA expression in normal human tissues for DCTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCTN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0) and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCTN3 Gene



Protein tissue co-expression partners for DCTN3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTN3 Gene:

DCTN3

SOURCE GeneReport for Unigene cluster for DCTN3 Gene:

Hs.511768

mRNA Expression by UniProt/SwissProt for DCTN3 Gene:

O75935-DCTN3_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.
genes like me logo Genes that share expression patterns with DCTN3: view

Primer Products

No data available for mRNA differential expression in normal tissues for DCTN3 Gene

Orthologs for DCTN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCTN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN3 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia DCTN3 34 35
  • 93.01 (n)
cow
(Bos Taurus)
Mammalia DCTN3 34 35
  • 89.96 (n)
mouse
(Mus musculus)
Mammalia Dctn3 34 16 35
  • 89.61 (n)
rat
(Rattus norvegicus)
Mammalia Dctn3 34
  • 89.61 (n)
oppossum
(Monodelphis domestica)
Mammalia DCTN3 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCTN3 34 35
  • 71.04 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1847 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25551 34
zebrafish
(Danio rerio)
Actinopterygii dctn3 34 35
  • 59.52 (n)
Dr.28565 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.260 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2692 35
  • 31 (a)
OneToOne
Species where no ortholog for DCTN3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCTN3 Gene

ENSEMBL:
Gene Tree for DCTN3 (if available)
TreeFam:
Gene Tree for DCTN3 (if available)

Paralogs for DCTN3 Gene

No data available for Paralogs for DCTN3 Gene

Variants for DCTN3 Gene

Sequence variations from dbSNP and Humsavar for DCTN3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10814127 -- 34,619,400(+) AAATA(A/G)TAATT intron-variant
rs10972167 -- 34,619,265(+) agggc(A/G)tacag intron-variant
rs10972168 -- 34,619,624(+) TCCCA(A/G)AGGAA intron-variant
rs10972169 -- 34,619,881(+) TACCC(A/G)GTACC intron-variant
rs10972170 -- 34,619,891(+) CCAGT(C/T)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN3 Gene

Variant ID Type Subtype PubMed ID
dgv12659n54 CNV loss 21841781
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv1161857 CNV deletion 26073780
nsv818699 CNV gain 17921354
nsv831543 CNV loss 17160897

Variation tolerance for DCTN3 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCTN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN3 Gene

Disorders for DCTN3 Gene

Relevant External Links for DCTN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTN3

No disorders were found for DCTN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTN3 Gene

Publications for DCTN3 Gene

  1. Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping. (PMID: 11306820) Mills D.R. … Jackson C.L. (Cytogenet. Cell Genet. 2001) 2 3 22 64
  2. Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells. (PMID: 9722614) Karki S. … Holzbaur E.L.F. (J. Cell Biol. 1998) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DCTN3 Gene

Sources for DCTN3 Gene

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