Aliases for DCTN3 Gene
External Ids for DCTN3 Gene
Previous GeneCards Identifiers for DCTN3 Gene
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for DCTN3 Gene
DCTN3 (Dynactin Subunit 3) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Innate Immune System. GO annotations related to this gene include structural molecule activity.
UniProtKB/Swiss-Prot for DCTN3 Gene
Together with dynein may be involved in spindle assembly and cytokinesis.