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Aliases for DCTN3 Gene

Aliases for DCTN3 Gene

  • Dynactin Subunit 3 2 3 5
  • Dynactin Complex Subunit 22 KDa Subunit 3 4
  • Dynactin 3 (P22) 2 3
  • DCTN22 3 4
  • Dynactin Light Chain 3
  • DCTN-22 3
  • P22 4

External Ids for DCTN3 Gene

Previous GeneCards Identifiers for DCTN3 Gene

  • GC09M034925
  • GC09M034782
  • GC09M034598
  • GC09M034603
  • GC09M034569

Summaries for DCTN3 Gene

Entrez Gene Summary for DCTN3 Gene

  • This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for DCTN3 Gene

DCTN3 (Dynactin Subunit 3) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for DCTN3 Gene

  • Together with dynein may be involved in spindle assembly and cytokinesis.

Gene Wiki entry for DCTN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN3 Gene

Genomics for DCTN3 Gene

Regulatory Elements for DCTN3 Gene

Promoters for DCTN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCTN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCTN3 Gene

Chromosome:
9
Start:
34,613,545 bp from pter
End:
34,620,523 bp from pter
Size:
6,979 bases
Orientation:
Minus strand

Genomic View for DCTN3 Gene

Genes around DCTN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN3 Gene

Proteins for DCTN3 Gene

  • Protein details for DCTN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75935-DCTN3_HUMAN
    Recommended name:
    Dynactin subunit 3
    Protein Accession:
    O75935
    Secondary Accessions:
    • A6NII7
    • B2RBM5
    • Q5T1I5
    • Q5T1I7
    • Q5T8G3
    • Q9BPU8

    Protein attributes for DCTN3 Gene

    Size:
    186 amino acids
    Molecular mass:
    21119 Da
    Quaternary structure:
    • Subunit of dynactin, a multiprotein complex associated with dynein.
    SequenceCaution:
    • Sequence=CAI13144.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14178.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14180.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCTN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTN3 Gene

Proteomics data for DCTN3 Gene at MOPED

Post-translational modifications for DCTN3 Gene

  • Ubiquitination at Lys 50 and Lys 156
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DCTN3 Gene

Domains & Families for DCTN3 Gene

Gene Families for DCTN3 Gene

Protein Domains for DCTN3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75935

UniProtKB/Swiss-Prot:

DCTN3_HUMAN :
  • Belongs to the dynactin subunit 3 family.
Family:
  • Belongs to the dynactin subunit 3 family.
genes like me logo Genes that share domains with DCTN3: view

Function for DCTN3 Gene

Molecular function for DCTN3 Gene

UniProtKB/Swiss-Prot Function:
Together with dynein may be involved in spindle assembly and cytokinesis.
genes like me logo Genes that share phenotypes with DCTN3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN3 Gene

Localization for DCTN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN3 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTN3 Gene COMPARTMENTS Subcellular localization image for DCTN3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005869 dynactin complex IPI 9722614
GO:0030496 midbody IEA --
GO:0032154 cleavage furrow IEA --
genes like me logo Genes that share ontologies with DCTN3: view

Pathways & Interactions for DCTN3 Gene

genes like me logo Genes that share pathways with DCTN3: view

Gene Ontology (GO) - Biological Process for DCTN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DCTN3: view

No data available for SIGNOR curated interactions for DCTN3 Gene

Drugs & Compounds for DCTN3 Gene

No Compound Related Data Available

Transcripts for DCTN3 Gene

Unigene Clusters for DCTN3 Gene

Dynactin 3 (p22):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8: - - - -
SP9: - - - -
SP10:
SP11: -

Relevant External Links for DCTN3 Gene

GeneLoc Exon Structure for
DCTN3
ECgene alternative splicing isoforms for
DCTN3

Expression for DCTN3 Gene

mRNA expression in normal human tissues for DCTN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCTN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.0) and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTN3 Gene



SOURCE GeneReport for Unigene cluster for DCTN3 Gene Hs.511768

mRNA Expression by UniProt/SwissProt for DCTN3 Gene

O75935-DCTN3_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain.
genes like me logo Genes that share expression patterns with DCTN3: view

Protein tissue co-expression partners for DCTN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DCTN3 Gene

Orthologs for DCTN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCTN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCTN3 35
  • 89.96 (n)
  • 94.09 (a)
DCTN3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCTN3 35
  • 93.01 (n)
  • 94.62 (a)
DCTN3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dctn3 35
  • 89.61 (n)
  • 94.09 (a)
Dctn3 16
Dctn3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCTN3 35
  • 99.64 (n)
  • 100 (a)
DCTN3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctn3 35
  • 89.61 (n)
  • 94.62 (a)
oppossum
(Monodelphis domestica)
Mammalia DCTN3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCTN3 35
  • 71.04 (n)
  • 69.4 (a)
DCTN3 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1847 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25551 35
zebrafish
(Danio rerio)
Actinopterygii dctn3 35
  • 59.52 (n)
  • 57.14 (a)
Dr.28565 35
dctn3 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.260 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2692 36
  • 31 (a)
OneToOne
Species with no ortholog for DCTN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCTN3 Gene

ENSEMBL:
Gene Tree for DCTN3 (if available)
TreeFam:
Gene Tree for DCTN3 (if available)

Paralogs for DCTN3 Gene

No data available for Paralogs for DCTN3 Gene

Variants for DCTN3 Gene

Sequence variations from dbSNP and Humsavar for DCTN3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3802427 -- 34,618,644(-) TGCCC(A/G)ACATC intron-variant
rs7865283 -- 34,615,803(+) GAGGC(A/G)AGGTG intron-variant
rs10814127 -- 34,619,400(+) AAATA(A/G)TAATT intron-variant
rs10972167 -- 34,619,265(+) agggc(A/G)tacag intron-variant
rs10972168 -- 34,619,624(+) TCCCA(A/G)AGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN3 Gene

Variant ID Type Subtype PubMed ID
nsv831543 CNV Loss 17160897
nsv893038 CNV Loss 21882294
nsv818699 CNV Gain 17921354

Variation tolerance for DCTN3 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTN3 Gene

HapMap Linkage Disequilibrium report
DCTN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN3 Gene

Disorders for DCTN3 Gene

Relevant External Links for DCTN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTN3

No disorders were found for DCTN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTN3 Gene

Publications for DCTN3 Gene

  1. Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells. (PMID: 9722614) Karki S. … Holzbaur E.L.F. (J. Cell Biol. 1998) 2 3 4 67
  2. Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping. (PMID: 11306820) Mills D.R. … Jackson C.L. (Cytogenet. Cell Genet. 2001) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for DCTN3 Gene

Sources for DCTN3 Gene

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