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DCTN3 Gene

protein-coding   GIFtS: 59
GCID: GC09M034614

Dynactin 3 (P22)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynactin 3 (P22)1 2     Dynactin Light Chain2
DCTN222 3 5     Dynactin Subunit 32
Dynactin Complex Subunit 22 KDa Subunit2 3     p223
DCTN-222     

External Ids:    HGNC: 27131   Entrez Gene: 112582   Ensembl: ENSG000001371007   OMIM: 6073875   UniProtKB: O759353   

Export aliases for DCTN3 gene to outside databases

Previous GC identifers: GC09M034925 GC09M034782 GC09M034598 GC09M034603 GC09M034569


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCTN3 Gene:
This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in
size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse
array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and
endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This
subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an
alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for DCTN3 Gene:
DCTN3 (dynactin 3 (p22)) is a protein-coding gene. Diseases associated with DCTN3 include ataxia, and prostate cancer. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot: DCTN3_HUMAN, O75935
Function: Together with dynein may be involved in spindle assembly and cytokinesis

Gene Wiki entry for DCTN3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCTN3 gene promoter:
         HOXA9   HOXA9B   p53   Brachyury   Nkx2-5   Nkx5-1   Meis-1b   HNF-1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCTN3 promoter sequence
   Search Chromatin IP Primers for DCTN3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCTN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

DCTN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTN3 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M034614:  view genomic region     (about GC identifiers)

Start:
34,613,548 bp from pter      End:
34,620,515 bp from pter
Size:
6,968 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCTN3_HUMAN, O75935 (See protein sequence)
Recommended Name: Dynactin subunit 3  
Size: 186 amino acids; 21119 Da
Subunit: Subunit of dynactin, a multiprotein complex associated with dynein
Sequence caution: Sequence=CAI13144.1; Type=Erroneous initiation; Sequence=CAI14178.1; Type=Erroneous gene model
prediction; Sequence=CAI14180.1; Type=Erroneous initiation;
Secondary accessions: A6NII7 B2RBM5 Q5T1I5 Q5T1I7 Q5T8G3 Q9BPU8
Alternative splicing: 3 isoforms:  O75935-1   O75935-2   O75935-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCTN3: NX_O75935

Explore proteomics data for DCTN3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys50, Lys156
  • Modification sites at PhosphoSitePlus

  • See DCTN3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001268354.1  NP_001268355.1  NP_001268356.1  NP_009165.1  NP_077324.1  

    ENSEMBL proteins: 
     ENSP00000390842   ENSP00000343986   ENSP00000259632   ENSP00000432915   ENSP00000368193  
     ENSP00000368191   ENSP00000368196   ENSP00000397046  
    Reactome Protein details: O75935

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR009991 Dynactin_p22

    Graphical View of Domain Structure for InterPro Entry O75935

    ProtoNet protein and cluster: O75935

    UniProtKB/Swiss-Prot: DCTN3_HUMAN, O75935
    Similarity: Belongs to the dynactin subunit 3 family


    DCTN3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCTN3_HUMAN, O75935
    Function: Together with dynein may be involved in spindle assembly and cytokinesis

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity TAS9722614
    GO:0005515protein binding IPI9722614
         
    DCTN3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DCTN3:
     Synthetic lethal with Ras 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCTN3_HUMAN, O75935: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome,
    centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Note=Localizes to punctate
    cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles
    throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005813centrosome IDA--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--
    GO:0005869dynactin complex IPI9722614

    DCTN3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCTN3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    2Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41
    5MHC class II antigen presentation
    MHC class II antigen presentation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DCTN3
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments


    5 Reactome Pathways for DCTN3
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    MHC class II antigen presentation
    Loss of Nlp from mitotic centrosomes



    DCTN3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCTN3
    Interactions:

        Search GeneGlobe Interaction Network for DCTN3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCTN3 (O759351, 2, 3 ENSP000002596324) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225987P404251, 2, 3, ENSP000004039484EBI-347442,EBI-348489 MINT-62576 MINT-62674 MINT-62750 I2D: score=4 STRING: ENSP00000403948
    ENSG00000237344P404251, 2, 3, ENSP000003971774EBI-347442,EBI-348489 MINT-62576 MINT-62674 MINT-62750 I2D: score=4 STRING: ENSP00000397177
    PBX2P404251, 2, 3, ENSP000003641904EBI-347442,EBI-348489 MINT-62576 MINT-62674 MINT-62750 I2D: score=4 STRING: ENSP00000364190
    ENSG00000206315P404251, 2, 3EBI-347442,EBI-348489 MINT-62576 MINT-62674 MINT-62750 I2D: score=4 
    ENSG00000224952P404251, 2, 3EBI-347442,EBI-348489 MINT-62576 MINT-62674 MINT-62750 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0000910cytokinesis IDA9722614
    GO:0007017microtubule-based process IEA--
    GO:0007067mitosis IEA--

    DCTN3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DCTN3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCTN3 gene (5 alternative transcripts): 
    NM_001281425.1  NM_001281426.1  NM_001281427.1  NM_007234.4  NM_024348.3  

    Unigene Cluster for DCTN3:

    Dynactin 3 (p22)
    Hs.511768  [show with all ESTs]
    Unigene Representative Sequence: BM920638
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472418 ENST00000479399 ENST00000421919 ENST00000341694(uc003zuw.1)
    ENST00000259632 ENST00000477738 ENST00000481438 ENST00000472074 ENST00000378913
    ENST00000378911 ENST00000378916 ENST00000447983(uc003zux.1)
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    Additional mRNA sequence: 

    AF082513.1 AK314730.1 BC000319.2 BC003004.1 BC107697.1 CR541889.1 

    12 DOTS entries:

    DT.444493  DT.95254845  DT.100655527  DT.75190318  DT.100784036  DT.100029170  DT.95174060  DT.97845255 
    DT.121184527  DT.121184538  DT.92430386  DT.65288339 

    Selected AceView cDNA sequences (see all 238):

    AW161839 BQ637048 AK055199 BM915956 AW249833 AX747117 AA480592 BQ681629 
    BM464498 AI564792 AA973565 BM545651 BU075737 BF219701 AA742922 F26918 
    CA312470 BU158801 BU165114 F00418 AA563604 AI418088 NM_024348 BM669742 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCTN3 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e
    SP1:                                      -           -     -     -           -     -     -           -                           
    SP2:                                      -           -     -     -           -                       -                           
    SP3:                                      -           -     -     -           -     -                 -                           
    SP4:                                      -     -     -     -     -           -     -     -           -                           
    SP5:                                      -           -     -     -           -     -     -     -                                 


    ECgene alternative splicing isoforms for DCTN3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCTN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCCGCCT
    DCTN3 Expression
    About this image


    DCTN3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
    DCTN3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCTN3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.511768

    UniProtKB/Swiss-Prot: DCTN3_HUMAN, O75935
    Tissue specificity: Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels
    in brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DCTN3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dctn31 , 5 dynactin 31, 5 89.61(n)1
    94.09(a)1
      4 (21.98 cM)5
    535981  NM_016890.41  NP_058586.31 
     417147985 
    chicken
    (Gallus gallus)
    Aves DCTN31 dynactin 3 (p22) 71.04(n)
    69.4(a)
      427404  NM_001031445.1  NP_001026616.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.255512 Xenopus laevis transcribed sequence with weak similarity more 74.01(n)    AW638286.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.285652 Transcribed sequence with weak similarity to protein more 70.75(n)    CK397060.1 


    ENSEMBL Gene Tree for DCTN3 (if available)
    TreeFam Gene Tree for DCTN3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCTN3 (see all 128)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461411851,2
    F--34614113(+) CAAAGT/CGTAGC 3 /H /R mis1 int11Minor allele frequency- C:0.00NA 4552
    rs747743111,2
    C,F--34614173(+) CATCAC/TGGACT 3 H R mis1 int13Minor allele frequency- T:0.01WA NA EU 5993
    rs2005780891,2
    C--34614192(+) CCATGC/GAGCCT 3 P A mis1 int10--------
    rs1411635861,2
    C--34614209(+) GATGAC/TGCTTA 2 -- int10--------
    rs743246881,2
    C,F--34614636(+) TTCCCC/GAGGTG 2 -- int11Minor allele frequency- G:0.01NA 120
    rs123528111,2
    C,F,H--34614681(+) TCTTCG/CCTTCT 2 -- int119Minor allele frequency- C:0.12NS EA NA WA CSA EU 3536
    rs1496660881,2
    F--34614719(+) TGAATG/ATGGAT 4 /H syn11Minor allele frequency- A:0.00NA 4552
    rs759293921,2
    C--34614769(-) GTTTTA/CCAGCC 2 -- int10--------
    rs1883876941,2
    --34614825(+) CTCAAC/TAGTCT 2 -- int10--------
    rs1169194101,2
    C,F--34614858(+) AGTATT/AGAGTG 2 -- int11Minor allele frequency- A:0.01EA 120

    HapMap Linkage Disequilibrium report for DCTN3 (34613548 - 34620515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DCTN3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893038CNV Loss21882294
    nsv831543CNV Loss17160897
    nsv818699CNV Gain17921354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607387    OMIM disorders: --

    3 diseases for DCTN3:    
    About MalaCards
    ataxia    prostate cancer    prostatitis


    DCTN3 for disorders           About GeneDecksing


    Export disorders for DCTN3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCTN3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with DCTN3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells. (PubMed id 9722614)1, 2, 3 Karki S.... Holzbaur E.L.F. (J. Cell Biol. 1998)
    2. Assignment of p22 dynactin light chain (DCTN3) to human chromosome region 9p13 by radiation hybrid mapping. (PubMed id 11306820)1, 3, 9 Mills D.R. and Jackson C.L. (Cytogenet. Cell Genet. 2001)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11258 HGNC: 2713 AceView: DCTN3 Ensembl:ENSG00000137100 euGenes: HUgn11258
    ECgene: DCTN3 H-InvDB: DCTN3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DCTN3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DCTN3 gene:
    Search GeneIP for patents involving DCTN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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