Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DCTN2 Gene

protein-coding GIFtS: 62
GCID: GC12M057924

dynactin 2 (p50)

Explore 10 diseases affiliated with
DCTN2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dynactin 2 (P50)¹ ²		P50 Dynamitin² ³
DCTN50² ³ ⁵		50 KD Dynein-Associated Polypeptide²
RBP50¹ ²		DYNAMITIN²
DCTN-50¹ ³		Dynactin Complex 50 KD Subunit²
Dynactin Complex 50 KDa Subunit² ³		Dynactin Subunit 2²
50 KDa Dynein-Associated Polypeptide² ³

External Ids:	HGNC: 2712¹	Entrez Gene: 10540²	Ensembl: ENSG00000175203⁷	OMIM: 607376⁵	UniProtKB: Q13561³

Export aliases for DCTN2 gene to outside databases

Previous GC identifers: GC12P059194 GC12M058067 GC12M057640 GC12M056210 GC12M054961

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DCTN2:

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size

from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of

cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle

formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per

dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or

other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in

place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

(provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: DCTN2_HUMAN, Q13561

Function: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment

and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse

formation during brain development

Gene Wiki entry for DCTN2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DCTN2 gene promoter:
HOXA9B HOXA9 HOXA3 SREBP-1c SREBP-1b PPAR-gamma1 SREBP-1a Meis-1a PPAR-gamma2 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DCTN2 promoter sequence

Search SABiosciences Chromatin IP Primers for DCTN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCTN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3

DCTN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTN2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M057924: view genomic region (about GC identifiers)

Start:	57,923,885 bp from pter	End:	57,941,114 bp from pter
Size:	17,230 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DCTN2_HUMAN, Q13561 (See protein sequence)

Recommended Name: Dynactin subunit 2

Size: 401 amino acids; 44231 Da

Subunit: Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135 (By

similarity). Interacts with DYNAP, ECM29 and MAPRE1

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Membrane; Peripheral membrane protein

Sequence caution: Sequence=AAO34395.1; Type=Frameshift; Positions=381;

Secondary accessions: B2RBK5 Q86YN2 Q9BW17

Alternative splicing: 3 isoforms: Q13561-1 Q13561-2 Q13561-3

Explore the universe of human proteins at neXtProt for DCTN2: NX_Q13561

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q13561

DCTN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001248341.1 NP_001248342.1 NP_006391.1

ENSEMBL proteins:

ENSP00000447824 ENSP00000408910 ENSP00000447372 ENSP00000346785 ENSP00000446964

ENSP00000447553 ENSP00000448937 ENSP00000447308 ENSP00000449855 ENSP00000448606

ENSP00000447518 ENSP00000449710 ENSP00000439376 ENSP00000445601

Reactome Protein details: Q13561
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: DCTN2 OriGene Protein Over-expression Lysate: DCTN2 OriGene Custom Protein Services for DCTN2
	GenScript Custom Purified and Recombinant Proteins Services for DCTN2
	Novus Biologicals DCTN2 Proteins Novus Biologicals DCTN2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DCTN2

Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000776	kinetochore	IDA	8647893
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	IDA	--
GO:0005829	cytosol	TAS	--

DCTN2 for ontologies About GeneDecksing

DCTN2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DCTN2
	R&D Systems Antibodies for DCTN2 (Dynactin Subunit 2/DCTN2)
	OriGene Antibodies (see all 2): DCTN2 OriGene Custom Antibody Services for DCTN2
	GenScript Custom Superior Antibodies Services for DCTN2
	Novus Biologicals DCTN2 Antibodies
	Abcam antibodies for DCTN2
	Uscn Antibodies for DCTN2
	ThermoFisher Antibodies for DCTN2

Assay Products for DCTN2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DCTN2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DCTN2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DCTN2 for domains About GeneDecksing

1 InterPro domain/family:

IPR006996 Dynamitin_2su

Graphical View of Domain Structure for InterPro Entry Q13561

ProtoNet protein and cluster: Q13561

1 Blocks protein family: IPB006996 Dynamitin

UniProtKB/Swiss-Prot: DCTN2_HUMAN, Q13561

Similarity: Belongs to the dynactin subunit 2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DCTN2_HUMAN, Q13561

Function: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment

and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse

formation during brain development

Genatlas biochemistry entry for DCTN2:

dynactin 2,component of a large macromolecular complex required for the cytoplasmic dynein-driven movement of

organelles along microtubules,homologious to Drosophila glued

miRNA Products:		OriGene 3'-UTR Clone: DCTN2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCTN2
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DCTN2 (see all 9):
		hsa-let-7a-2* hsa-miR-548b-3p hsa-miR-1911* hsa-miR-199a-5p hsa-miR-144 hsa-miR-199b-5p hsa-miR-4310 hsa-let-7g*

		SwitchGear 3'UTR luciferase reporter plasmid: DCTN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCTN2 (see all 7) OriGene siRNA: DCTN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCTN2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DCTN2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DCTN2 (NM_006400)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCTN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DCTN2
		Search LifeMap BioReagents cell lines for DCTN2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003774	motor activity	IEA	--
GO:0005515	protein binding	IPI	17043677

DCTN2 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for DCTN2:

Decreased POU5F1-GFP protein e

Increased cell number in G1, s

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Recruitment of mitotic centrosome proteins and complexes

Recruitment of mitotic centrosome proteins and complexes	1.00	Mitotic G2-G2/M phases	0.81
Centrosome maturation	1.00	Loss of proteins required for interphase microtubule organizationÂ from the centrosome	0.78
G2/M Transition	0.83	Loss of Nlp from mitotic centrosomes	0.78

Cytoskeleton remodeling Neurofilaments

	Cytoskeleton remodeling Neurofilaments	1.00			Cytoplasmic microtubules	0.32
	Cytoskeleton remodeling_Neurofilaments	0.91

Cell cycle_Spindle assembly and chromosome separation

Cell cycle_Spindle assembly and chromosome separation

1.00

Cell cycle Spindle assembly and chromosome separation

0.94

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for DCTN2

	Cell cycle Spindle assembly and chromosome separation
	Cytoskeleton remodeling Neurofilaments
	Cytoplasmic microtubules

2 GeneGo (Thomson Reuters) Pathways for DCTN2

	Cell cycle Spindle assembly and chromosome separation
	Cytoskeleton remodeling Neurofilaments

5/12 Reactome Pathways for DCTN2 (see all 12)

	Centrosome maturation
	Cell Cycle
	Recruitment of mitotic centrosome proteins and complexes
	Adaptive Immune System
	Transport of antigen loaded MHC II molecules to surface

2 Kegg Pathways (Kegg details for DCTN2):

	Vasopressin-regulated water reabsorption
	Huntington's disease

DCTN2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DCTN2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/872 Interacting proteins for DCTN2 (Q13561^{1, 2, 3} ENSP00000408910⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 872)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TSG101	Q99816²^,³, ENSP00000251968⁴	MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000251968
GADD45A	P24522²^,³, ENSP00000360025⁴	MINT-66121 I2D: score=5 STRING: ENSP00000360025
GOLM1	Q8NBJ4²^,³, ENSP00000373363⁴	MINT-64965 I2D: score=5 STRING: ENSP00000373363
DISC1	Q9NRI5¹^,³, ENSP00000355596⁴	EBI-715074,EBI-529989 I2D: score=2 STRING: ENSP00000355596
GSK3B	P49841²^,³, ENSP00000324806⁴	MINT-4049943 I2D: score=1 STRING: ENSP00000324806

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007017	microtubule-based process	--	--
GO:0007052	mitotic spindle organization	IEA	--
GO:0007067	mitosis	IMP	8647893

DCTN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DCTN2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DCTN2
3 Novoseek chemical compound relationships for DCTN2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nocodazole	76.7	2	11017881 (1), 12403812 (1)
paclitaxel	40.2	1	15485845 (1)
tyrosine	0	1	12082093 (1)

Search CenterWatch for drugs/clinical trials and news about DCTN2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DCTN2 gene (3 alternative transcripts):

NM_001261412.1 NM_001261413.1 NM_006400.4

Unigene Cluster for DCTN2:

Dynactin 2 (p50)

Hs.289123 [show with all ESTs]

Unigene Representative Sequence: AK022171

18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):

ENST00000548249(uc001som.1) ENST00000434715 ENST00000552811 ENST00000354743

ENST00000550201 ENST00000549394 ENST00000546758 ENST00000550988 ENST00000552390

ENST00000550086 ENST00000550954 ENST00000551872 ENST00000548736 ENST00000546670

ENST00000551611 ENST00000546965 ENST00000550750 ENST00000548949

miRNA Products:		OriGene 3'-UTR Clone: DCTN2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCTN2
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DCTN2 (see all 9):
		hsa-let-7a-2* hsa-miR-548b-3p hsa-miR-1911* hsa-miR-199a-5p hsa-miR-144 hsa-miR-199b-5p hsa-miR-4310 hsa-let-7g*

		SwitchGear 3'UTR luciferase reporter plasmid: DCTN2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCTN2 (see all 7) OriGene siRNA: DCTN2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCTN2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DCTN2 (NM_006400)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCTN2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCTN2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DCTN2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCTN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCTN2

Additional cDNA sequence:

AK022171.1 AK055682.1 AK096242.1 AK098794.1 AK222693.1 AK292364.1 AK314705.1 AY189155.1

BC000718.2 BC009468.1 BC014083.2 U50733.1

24/42 DOTS entries (see all 42):

DT.449130 DT.95273168 DT.100658694 DT.100884095 DT.100884084 DT.121174542 DT.100884086 DT.100884101

DT.95273156 DT.100884087 DT.100031092 DT.91826426 DT.121174369 DT.121174538 DT.100830213 DT.121174597

DT.75146547 DT.91850276 DT.92454398 DT.100028132 DT.40193396 DT.86847079 DT.92006325 DT.92454410

24/740 AceView cDNA sequences (see all 740):

BE273513 BM969164 CR590859 CR606365 CR620231 BQ933460 BM842937 BE869248

CB149879 BC009468 BX438252 CR611056 AI767136 CR594105 BM793311 BU173259

BQ030205 BE794876 BQ670185 AA448055 BQ882366 BG180836 AU123456 CB216870

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DCTN2 (see all 13) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11	^	12	^
SP1:													-						-				-												-
SP2:													-						-		-		-												-
SP3:													-						-		-		-												-		-		-
SP4:																																			-
SP5:													-		-		-		-		-		-												-

ExUns:	13	^	14a	·	14b	^	15	^	16a	·	16b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DCTN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DCTN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAATACTG

About this image
See DCTN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCTN2

SOURCE GeneReport for Unigene cluster: Hs.289123

SABiosciences Custom PCR Arrays for DCTN2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCTN2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DCTN2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCTN2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCTN2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DCTN2 gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dctn2^{1 , 5}	dynactin 2^{1, 5}	89.9(n)¹ 95.81(a)¹		10 (74.50 cM)⁵ 69654¹ NM_001190454.1¹ NP_001177383.1¹ 127266262⁵
chicken (Gallus gallus)	Aves	DCTN2¹	dynactin 2 (p50)	68.18(n) 67.76(a)		395587 NM_204802.1 NP_990133.1
lizard (Anolis carolinensis)	Reptilia	DCTN2⁶	--	82(a)	1 ↔ 1	GL343212.1(496063-506636)
African clawed frog (Xenopus laevis)	Amphibia	dctn2-prov²	dynactin 2 (p50)	79.26(n)		BC044069.1
zebrafish (Danio rerio)	Actinopterygii	zgc63867²	similar to dynactin 2 (p50)	76.31(n)		394141 BC053120.1
fruit fly (Drosophila melanogaster)	Insecta	Dmn^{1 , 3}	microtubule-based movement³ Dynamitin¹	31(a)³ 47.79(n)¹ 35.23(a)¹		44F3³ 44086¹ NM_079951.2¹ NP_524690.1¹
worm (Caenorhabditis elegans)	Secernentea	dnc-2¹	Protein DNC-2	41.27(n) 27.27(a)		175837 NM_065885.4 NP_498286.1

ENSEMBL Gene Tree for DCTN2 (if available)
TreeFam Gene Tree for DCTN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112643370^1,2	C	--	57923451(+)	`TCCCAC/G/TTGAAA`	5	--	ds500¹ ut3¹		1		CSA	1
rs75775181^1,2	F,	--	57923504(+)	`CAACAC/GCCCTC`	4	--	ds500¹ ut3¹		1		EA	120
rs187864696^1,2		--	57923513(+)	`TCTGCC/TTCTGG`	4	--	ut3¹ ds500¹		0	--	--	--	--
rs191077534^1,2		--	57923767(+)	`CGGAGC/TGGCCA`	4	--	ut3¹ ds500¹		0	--	--	--	--
rs14932^1,2	C	--	57923831(-)	`CTCCCA/GAGGGT`	4	--	ds500¹ ut3¹		3		MN NA	188
rs182106210^1,2		--	57923885(+)	`TTTCTA/GTGGGA`	4	--	ut3¹		0	--	--	--	--
rs187957221^1,2		--	57924032(+)	`TGTTAC/TGACGA`	4	--	ut3¹ int¹		0	--	--	--	--
rs73346010^1,2	C,	--	57924035(+)	`TATGAC/TGAATG`	4	--	int¹ ut3¹		2		WA	120
rs775324^1,2	C,F,A,H,	--	57924050(-)	`TAGGAT/CATAGA`	4	--	ut3¹ int¹		24		NS EA NA WA CSA	2349
rs111968899^1,2	C	--	57924093(+)	`GCCACT/ACAGAG`	4	--	ut3¹ int¹		1		CSA	1

HapMap Linkage Disequilibrium report for DCTN2 (57923885 - 57941114 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DCTN2
1 CNV: 3891
1 Indel: 58586

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCTN2

DNA2.0 Custom Variant and Variant Library Synthesis for DCTN2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DCTN2 for disorders           About GeneDecksing

OMIM gene information: 607376    OMIM disorders: --

10 diseases for DCTN2:    About MalaCards

human t-cell leukemia virus type 1 retinitis pigmentosa t-cell leukemia huntington's disease

retinitis leukemia osteosarcoma schizophrenia

immunodeficiency neuronitis

1 Novoseek disease relationship for DCTN2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0	1	16369996 (1)

Export disorders for DCTN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DCTN2 gene, integrated from 9 sources (see all 122):
(articles sorted by number of sources associating them with DCTN2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. (PubMed id 8647893)^{1, 2, 3} Echeverri C.J.... Vallee R.B. (1996)
The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. (PubMed id 10226031)^{1, 2, 9} Berrueta L.... Bierer B.E. (1999)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading. (PubMed id 10827182)^{1, 9} Yue L....Li J. (2000)
Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure. (PubMed id 18182012)^{1, 9} Maier K.C....Schroer T.A. (2008)
Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end. (PubMed id 10525537)^{1, 9} Eckley D.M....Schroer T.A. (1999)
Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells. (PubMed id 16369996)^{1, 9} Bransfield K.L....Mighell A.J. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10540	HGNC: 2712	AceView: DCTN2	Ensembl:ENSG00000175203	euGenes: HUgn10540
ECgene: DCTN2	Kegg: 10540	H-InvDB: DCTN2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DCTN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DCTN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DCTN2 gene:
Search GeneIP for patents involving DCTN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DCTN2
	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for DCTN2 (Dynactin Subunit 2/DCTN2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for DCTN2		Browse OriGene shRNA RFPs
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCTN2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCTN2
	OriGene Protein Over-expression Lysate for DCTN2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DCTN2		OriGene 3'-UTR Clone for DCTN2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCTN2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for DCTN2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DCTN2		OriGene Custom Protein Services for DCTN2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCTN2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCTN2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCTN2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCTN2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCTN2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCTN2

	GenScript Custom Purified and Recombinant Proteins Services for DCTN2		GenScript cDNA clones with any tag delivered in your preferred vector for DCTN2
	GenScript Custom Assay Services for DCTN2		GenScript Custom Superior Antibodies Services for DCTN2
	GenScript Custom overexpressing Cell Line Services for DCTN2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DCTN2 promoter
	Search Chromatin IP Primers for DCTN2
	RT² qPCR Primer Assay in human, mouse, rat DCTN2
	GNC Network for DCTN2
	SABiosciences Custom PCR Arrays for DCTN2

Search Tocris compounds for DCTN2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DCTN2 antibodies
	DCTN2 proteins
	DCTN2 lysates

	Antibodies for DCTN2
	See all of Abcam's Antibodies, Kits and Proteins for DCTN2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

DCTN2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DCTN2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTN2

	SwitchGear 3'UTR luciferase reporter plasmids for DCTN2
	SwitchGear Promoter luciferase reporter plasmids for DCTN2

ThermoFisher Antibodies for DCTN2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTN2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DCTN2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

DCTN2 Gene

dynactin 2 (p50)

Aliases
for DCTN2 gene

Summaries
for DCTN2 gene

Genomic Views
for DCTN2 gene

Proteins
for DCTN2 gene

Protein Domains /
Families
for DCTN2 gene

Function
for DCTN2 gene

Pathways & Interactions
for DCTN2 gene

Drugs & Compounds
for DCTN2 gene

Transcripts
for DCTN2 gene

Expression
for DCTN2 gene

Orthologs
for DCTN2 gene

Paralogs
for DCTN2 gene

Genomic Variants
for DCTN2 gene

Disorders / Diseases
for DCTN2 gene

Publications
for DCTN2 gene

External Searches for DCTN2 gene

Genome Databases showing DCTN2 gene

Other Databases showing DCTN2 gene

Specialized Databases showing DCTN2 gene

Intellectual Property
for DCTN2 gene

Products
for DCTN2 gene

View Random Gene

Advanced Search

Export list of displayed genes

DCTN2 Gene

dynactin 2 (p50)

Aliasesfor DCTN2 gene

Summariesfor DCTN2 gene

Genomic Viewsfor DCTN2 gene

Proteinsfor DCTN2 gene

Protein Domains /Familiesfor DCTN2 gene

Functionfor DCTN2 gene

Pathways & Interactionsfor DCTN2 gene

Drugs & Compoundsfor DCTN2 gene

Transcriptsfor DCTN2 gene

Expression for DCTN2 gene

Orthologsfor DCTN2 gene

Paralogsfor DCTN2 gene

Genomic Variantsfor DCTN2 gene

Disorders / Diseasesfor DCTN2 gene

Publicationsfor DCTN2 gene

External Searches for DCTN2 gene

Genome Databases showing DCTN2 gene

Other Databases showing DCTN2 gene

Specialized Databases showing DCTN2 gene

Intellectual Propertyfor DCTN2 gene

Productsfor DCTN2 gene

View Random Gene

Aliases
for DCTN2 gene

Summaries
for DCTN2 gene

Genomic Views
for DCTN2 gene

Proteins
for DCTN2 gene

Protein Domains /
Families
for DCTN2 gene

Function
for DCTN2 gene

Pathways & Interactions
for DCTN2 gene

Drugs & Compounds
for DCTN2 gene

Transcripts
for DCTN2 gene

Expression
for DCTN2 gene

Orthologs
for DCTN2 gene

Paralogs
for DCTN2 gene

Genomic Variants
for DCTN2 gene

Disorders / Diseases
for DCTN2 gene

Publications
for DCTN2 gene

Intellectual Property
for DCTN2 gene

Products
for DCTN2 gene