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Aliases for DCTN2 Gene

Aliases for DCTN2 Gene

  • Dynactin Subunit 2 2 3 5
  • 50 KDa Dynein-Associated Polypeptide 3 4
  • Dynactin Complex 50 KDa Subunit 3 4
  • Dynactin 2 (P50) 2 3
  • P50 Dynamitin 3 4
  • DCTN50 3 4
  • 50 KD Dynein-Associated Polypeptide 3
  • Epididymis Secretory Protein Li 77 3
  • Dynactin Complex 50 KD Subunit 3
  • DYNAMITIN 3
  • HEL-S-77 3
  • DCTN-50 4
  • RBP50 3

External Ids for DCTN2 Gene

Previous GeneCards Identifiers for DCTN2 Gene

  • GC12P059194
  • GC12M058067
  • GC12M057640
  • GC12M056210
  • GC12M057924
  • GC12M054961

Summaries for DCTN2 Gene

Entrez Gene Summary for DCTN2 Gene

  • This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for DCTN2 Gene

DCTN2 (Dynactin Subunit 2) is a Protein Coding gene. Diseases associated with DCTN2 include retinitis pigmentosa. Among its related pathways are Transport to the Golgi and subsequent modification and Immune System. GO annotations related to this gene include motor activity and spectrin binding.

UniProtKB/Swiss-Prot for DCTN2 Gene

  • Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.

Gene Wiki entry for DCTN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN2 Gene

Genomics for DCTN2 Gene

Regulatory Elements for DCTN2 Gene

Promoters for DCTN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCTN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCTN2 Gene

Chromosome:
12
Start:
57,530,050 bp from pter
End:
57,547,331 bp from pter
Size:
17,282 bases
Orientation:
Minus strand

Genomic View for DCTN2 Gene

Genes around DCTN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN2 Gene

Proteins for DCTN2 Gene

  • Protein details for DCTN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13561-DCTN2_HUMAN
    Recommended name:
    Dynactin subunit 2
    Protein Accession:
    Q13561
    Secondary Accessions:
    • B2RBK5
    • Q86YN2
    • Q9BW17

    Protein attributes for DCTN2 Gene

    Size:
    401 amino acids
    Molecular mass:
    44231 Da
    Quaternary structure:
    • Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135 (By similarity). Interacts with DYNAP, ECM29 and MAPRE1.
    SequenceCaution:
    • Sequence=AAO34395.1; Type=Frameshift; Positions=381; Evidence={ECO:0000305};

    Alternative splice isoforms for DCTN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTN2 Gene

Proteomics data for DCTN2 Gene at MOPED

Post-translational modifications for DCTN2 Gene

  • Ubiquitination at Lys 140, Lys 146, and Lys 175
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for DCTN2 (Dynactin Subunit 2/DCTN2)

No data available for DME Specific Peptides for DCTN2 Gene

Domains & Families for DCTN2 Gene

Gene Families for DCTN2 Gene

Protein Domains for DCTN2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13561

UniProtKB/Swiss-Prot:

DCTN2_HUMAN :
  • Belongs to the dynactin subunit 2 family.
Family:
  • Belongs to the dynactin subunit 2 family.
genes like me logo Genes that share domains with DCTN2: view

Function for DCTN2 Gene

Molecular function for DCTN2 Gene

GENATLAS Biochemistry:
dynactin 2,component of a large macromolecular complex required for the cytoplasmic dynein-driven movement of organelles along microtubules,homologious to Drosophila glued
UniProtKB/Swiss-Prot Function:
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
genes like me logo Genes that share phenotypes with DCTN2: view

Animal Model Products

miRNA for DCTN2 Gene

miRTarBase miRNAs that target DCTN2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN2 Gene

Localization for DCTN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTN2 Gene COMPARTMENTS Subcellular localization image for DCTN2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
golgi apparatus 3
nucleus 3
endosome 2
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DCTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 8647893
GO:0030426 growth cone IEA --
GO:0031982 vesicle IDA 20682791
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with DCTN2: view

Pathways & Interactions for DCTN2 Gene

genes like me logo Genes that share pathways with DCTN2: view

Gene Ontology (GO) - Biological Process for DCTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0007052 mitotic spindle organization IBA --
GO:0008152 metabolic process IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DCTN2: view

No data available for SIGNOR curated interactions for DCTN2 Gene

Drugs & Compounds for DCTN2 Gene

(3) Drugs for DCTN2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with DCTN2: view

Transcripts for DCTN2 Gene

Unigene Clusters for DCTN2 Gene

Dynactin 2 (p50):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - - - -
SP6: - - - -
SP7:
SP8:
SP9:
SP10: - - - -
SP11: -
SP12: -
SP13:

ExUns: 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for DCTN2 Gene

GeneLoc Exon Structure for
DCTN2
ECgene alternative splicing isoforms for
DCTN2

Expression for DCTN2 Gene

mRNA expression in normal human tissues for DCTN2 Gene

Protein differential expression in normal tissues from HIPED for DCTN2 Gene

This gene is overexpressed in Bone marrow stromal cell (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTN2 Gene



SOURCE GeneReport for Unigene cluster for DCTN2 Gene Hs.289123

genes like me logo Genes that share expression patterns with DCTN2: view

Protein tissue co-expression partners for DCTN2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTN2 Gene

Orthologs for DCTN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCTN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN2 36
  • 99 (a)
OneToOne
DCTN2 35
  • 99.83 (n)
  • 99.75 (a)
cow
(Bos Taurus)
Mammalia DCTN2 35
  • 92.6 (n)
  • 96.76 (a)
DCTN2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCTN2 36
  • 96 (a)
OneToOne
DCTN2 35
  • 91.56 (n)
  • 95.04 (a)
mouse
(Mus musculus)
Mammalia Dctn2 16
Dctn2 36
  • 96 (a)
OneToOne
Dctn2 35
  • 89.58 (n)
  • 95.53 (a)
rat
(Rattus norvegicus)
Mammalia Dctn2 35
  • 89.44 (n)
  • 96.01 (a)
chicken
(Gallus gallus)
Aves DCTN2 35
  • 68.18 (n)
  • 67.76 (a)
DCTN2 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCTN2 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dctn2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn2 35
  • 72.21 (n)
  • 80.15 (a)
Str.13521 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10368 35
zebrafish
(Danio rerio)
Actinopterygii dctn2 36
  • 70 (a)
OneToOne
dctn2 35
  • 65.67 (n)
  • 69.98 (a)
zgc63867 35
African malaria mosquito
(Anopheles gambiae)
Insecta DCTN2_ANOGA 35
  • 48.2 (n)
  • 35.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dmn 36
  • 34 (a)
OneToOne
Dmn 37
  • 31 (a)
Dmn 35
  • 47.97 (n)
  • 35.23 (a)
worm
(Caenorhabditis elegans)
Secernentea dnc-2 35
  • 44.35 (n)
  • 31.78 (a)
dnc-2 36
  • 24 (a)
OneToOne
Species with no ortholog for DCTN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN2 Gene

ENSEMBL:
Gene Tree for DCTN2 (if available)
TreeFam:
Gene Tree for DCTN2 (if available)

Paralogs for DCTN2 Gene

No data available for Paralogs for DCTN2 Gene

Variants for DCTN2 Gene

Sequence variations from dbSNP and Humsavar for DCTN2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs14931 -- 57,532,784(-) GCAAA(A/G)GTGAG nc-transcript-variant, reference, synonymous-codon
rs703837 -- 57,532,689(+) TTCCA(A/G)AGTCC intron-variant
rs703838 -- 57,533,732(+) CGCCA(C/G)TGCAC intron-variant
rs775236 -- 57,544,540(+) CTCCA(C/T)AGTAG intron-variant
rs1709870 -- 57,534,036(+) CCCAG(G/T)GGTTT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DCTN2 Gene

Variant ID Type Subtype PubMed ID
nsv899117 CNV Loss 21882294
nsv899118 CNV Gain 21882294
dgv513e1 CNV Complex 17122850
nsv428283 CNV Gain 18775914
nsv724 CNV Insertion 18451855
nsv819927 CNV Loss 19587683

Variation tolerance for DCTN2 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTN2 Gene

HapMap Linkage Disequilibrium report
DCTN2
Human Gene Mutation Database (HGMD)
DCTN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN2 Gene

Disorders for DCTN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCTN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search DCTN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCTN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTN2
genes like me logo Genes that share disorders with DCTN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCTN2 Gene

Publications for DCTN2 Gene

  1. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. (PMID: 8647893) Echeverri C.J. … Vallee R.B. (J. Cell Biol. 1996) 2 3 4 67
  2. Intracellular transport of human immunodeficiency virus type 1 genomic RNA and viral production are dependent on dynein motor function and late endosome positioning. (PMID: 19286658) Lehmann M. … Mouland A.J. (J. Biol. Chem. 2009) 3 23
  3. Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure. (PMID: 18182012) Maier K.C. … Schroer T.A. (Traffic 2008) 3 23
  4. Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells. (PMID: 16369996) Bransfield K.L. … Mighell A.J. (Mol. Carcinog. 2006) 3 23
  5. RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. (PMID: 16043481) Khanna H. … Swaroop A. (J. Biol. Chem. 2005) 3 23

Products for DCTN2 Gene

Sources for DCTN2 Gene

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