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DCTN2 Gene

protein-coding   GIFtS: 64
GCID: GC12M057924

Dynactin 2 (P50)

  Search for DCTN2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dynactin 2 (P50)1 2     HEL-S-772
DCTN502 3 5     RBP502
Dynactin Complex 50 KDa Subunit2 3     Dynactin Complex 50 KD Subunit2
50 KDa Dynein-Associated Polypeptide2 3     Dynactin Subunit 22
P50 Dynamitin2 3     Epididymis Secretory Protein Li 772
50 KD Dynein-Associated Polypeptide2     DCTN-503
DYNAMITIN2     

External Ids:    HGNC: 27121   Entrez Gene: 105402   Ensembl: ENSG000001752037   OMIM: 6073765   UniProtKB: Q135613   

Export aliases for DCTN2 gene to outside databases

Previous GC identifers: GC12P059194 GC12M058067 GC12M057640 GC12M056210 GC12M054961


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCTN2 Gene:
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in
size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse
array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and
endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present
in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate
association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of
dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct
isoforms have been found for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for DCTN2 Gene:
DCTN2 (dynactin 2 (p50)) is a protein-coding gene. GO annotations related to this gene include motor activity.

UniProtKB/Swiss-Prot: DCTN2_HUMAN, Q13561
Function: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome
alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a
role in synapse formation during brain development

Gene Wiki entry for DCTN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCTN2 gene promoter:
         HOXA9B   HOXA9   HOXA3   SREBP-1c   SREBP-1b   PPAR-gamma1   SREBP-1a   Meis-1a   PPAR-gamma2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCTN2 promoter sequence
   Search Chromatin IP Primers for DCTN2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCTN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

DCTN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTN2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057924:  view genomic region     (about GC identifiers)

Start:
57,923,885 bp from pter      End:
57,941,114 bp from pter
Size:
17,230 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCTN2_HUMAN, Q13561 (See protein sequence)
Recommended Name: Dynactin subunit 2  
Size: 401 amino acids; 44231 Da
Subunit: Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135 (By
similarity). Interacts with DYNAP, ECM29 and MAPRE1
Sequence caution: Sequence=AAO34395.1; Type=Frameshift; Positions=381;
Secondary accessions: B2RBK5 Q86YN2 Q9BW17
Alternative splicing: 3 isoforms:  Q13561-1   Q13561-2   Q13561-3   

Explore the universe of human proteins at neXtProt for DCTN2: NX_Q13561

Explore proteomics data for DCTN2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys140, Lys146, Lys175
  • Modification sites at PhosphoSitePlus

  • See DCTN2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001248341.1  NP_001248342.1  NP_006391.1  

    ENSEMBL proteins: 
     ENSP00000447824   ENSP00000408910   ENSP00000446964   ENSP00000447553   ENSP00000448937  
     ENSP00000447308   ENSP00000449855   ENSP00000448606   ENSP00000449710   ENSP00000439376  
     ENSP00000445601  
    Reactome Protein details: Q13561

    DCTN2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR028133 Dynamitin

    Graphical View of Domain Structure for InterPro Entry Q13561

    ProtoNet protein and cluster: Q13561

    1 Blocks protein domain: IPB006996 Dynamitin

    UniProtKB/Swiss-Prot: DCTN2_HUMAN, Q13561
    Similarity: Belongs to the dynactin subunit 2 family


    Find genes that share domains with DCTN2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCTN2_HUMAN, Q13561
    Function: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome
    alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a
    role in synapse formation during brain development

         Genatlas biochemistry entry for DCTN2:
    dynactin 2,component of a large macromolecular complex required for the cytoplasmic dynein-driven movement of
    organelles along microtubules,homologious to Drosophila glued

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0005515protein binding IPI10226031
         
    Find genes that share ontologies with DCTN2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for DCTN2:
     Decreased POU5F1-GFP protein e  Increased cell number in G1, s  Increased gamma-H2AX phosphory 

    Animal Models:
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    miRTarBase miRNAs that target DCTN2:
    hsa-mir-18a-5p (MIRT050704), hsa-mir-502-3p (MIRT037985), hsa-mir-149-5p (MIRT045677)

    Block miRNA regulation of human, mouse, rat DCTN2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCTN2 (see all 9):
    hsa-let-7a-2* hsa-miR-548b-3p hsa-miR-1911* hsa-miR-199a-5p hsa-miR-144 hsa-miR-199b-5p hsa-miR-4310 hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidDCTN2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCTN2_HUMAN, Q13561: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral
    membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    endosome2
    golgi apparatus2
    nucleus2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA8647893
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--
    GO:0005869dynactin complex IDA8647893

    Find genes that share ontologies with DCTN2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCTN2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    2Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with DCTN2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for DCTN2
        Cell cycle Spindle assembly and chromosome separation
    Cytoskeleton remodeling Neurofilaments


    5 Reactome Pathways for DCTN2
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    MHC class II antigen presentation
    Loss of Nlp from mitotic centrosomes


    2 Kegg Pathways  (Kegg details for DCTN2):
        Vasopressin-regulated water reabsorption
    Huntington's disease

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCTN2
    Interactions:

        GeneGlobe Interaction Network for DCTN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCTN2 (Q135611, 2, 3 ENSP000004089104) via UniProtKB, MINT, STRING, and/or I2D (see all 950)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998162, 3, ENSP000002519684MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000251968
    GADD45AP245222, 3, ENSP000003600254MINT-66121 I2D: score=5 STRING: ENSP00000360025
    GOLM1Q8NBJ42, 3, ENSP000003733634MINT-64965 I2D: score=5 STRING: ENSP00000373363
    DISC1Q9NRI51, 3, ENSP000003555964EBI-715074,EBI-529989 I2D: score=2 STRING: ENSP00000355596
    GSK3BP498412, 3, ENSP000003248064MINT-4049943 I2D: score=1 STRING: ENSP00000324806
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007017microtubule-based process ----
    GO:0007052mitotic spindle organization IEA--
    GO:0007067mitosis IMP8647893

    Find genes that share ontologies with DCTN2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCTN2

    3 Novoseek inferred chemical compound relationships for DCTN2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 76.7 2 11017881 (1), 12403812 (1)
    paclitaxel 40.2 1 15485845 (1)
    tyrosine 0 1 12082093 (1)



    Find genes that share compounds with DCTN2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCTN2 gene (3 alternative transcripts): 
    NM_001261412.1  NM_001261413.1  NM_006400.4  

    Unigene Cluster for DCTN2:

    Dynactin 2 (p50)
    Hs.289123  [show with all ESTs]
    Unigene Representative Sequence: AK022171
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000548249(uc001som.1) ENST00000434715 ENST00000550201 ENST00000549394
    ENST00000546758 ENST00000550988 ENST00000552390 ENST00000550086 ENST00000550954
    ENST00000551872 ENST00000548736 ENST00000546670 ENST00000551611 ENST00000546965
    ENST00000550750 ENST00000548949 ENST00000551142 ENST00000547345
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DCTN2 (see all 9):
    hsa-let-7a-2* hsa-miR-548b-3p hsa-miR-1911* hsa-miR-199a-5p hsa-miR-144 hsa-miR-199b-5p hsa-miR-4310 hsa-let-7g*
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    Additional mRNA sequence: 

    AK022171.1 AK055682.1 AK096242.1 AK098794.1 AK222693.1 AK292364.1 AK314705.1 AY189155.1 
    BC000718.2 BC009468.1 BC014083.2 U50733.1 

    Selected DOTS entries (see all 42):

    DT.449130  DT.95273168  DT.100658694  DT.100884095  DT.100884084  DT.121174542  DT.100884086  DT.100884101 
    DT.121174597  DT.416114  DT.95273156  DT.100884087  DT.100031092  DT.100788549  DT.91826426  DT.121174369 
    DT.121174538  DT.100830213  DT.75146547  DT.91850276  DT.92454398  DT.100028132  DT.40193396  DT.86847079 

    Selected AceView cDNA sequences (see all 740):

    AV727431 AW005620 CA393094 BF446672 BI871730 BE222697 BQ919150 BU188526 
    CR606365 BG760702 AA360957 BM663142 BM747295 BP338795 BM969164 CR614261 
    CR623357 BE886926 AI241600 BM927460 CR594105 F03361 BU173259 AA337161 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCTN2 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^
    SP1:                                      -                 -           -                                   -                                                   
    SP2:                                      -                 -     -     -                                   -                                                   
    SP3:                                      -                 -     -     -                                   -     -     -                                       
    SP4:                                                                                                        -                                                   
    SP5:                                      -     -     -     -     -     -                                   -                                                   

    ExUns: 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for DCTN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DCTN2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAATACTG
    DCTN2 Expression
    About this image


    DCTN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
    DCTN2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCTN2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.289123
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DCTN2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dctn21 , 5 dynactin 21, 5 89.58(n)1
    95.53(a)1
      10 (74.50 cM)5
    696541  NM_001190454.11  NP_001177383.11 
     1272662625 
    chicken
    (Gallus gallus)
    Aves DCTN21 dynactin 2 (p50) 68.18(n)
    67.76(a)
      395587  NM_204802.1  NP_990133.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCTN26
    dynactin 2 (p50)
    86(a)
    1 ↔ 1
    GL343212.1(458537-506636)
    African clawed frog
    (Xenopus laevis)
    Amphibia dctn2-prov2 dynactin 2 (p50) 79.26(n)    BC044069.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638672 similar to dynactin 2 (p50) 76.31(n)   394141  BC053120.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dmn1 , 3 microtubule-based movement3
    Dynamitin1
    31(a)3
    47.97(n)1
    35.23(a)1
      44F33
    440861  NM_079951.21  NP_524690.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dnc-21 dnc-2 44.35(n)
    31.78(a)
      175837  NM_065885.5  NP_498286.1 


    ENSEMBL Gene Tree for DCTN2 (if available)
    TreeFam Gene Tree for DCTN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCTN2 (see all 342)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1848238531,2
    C--57924435(+) CAGGGC/GTAGGG 3 -- ut310--------
    rs556402081,2
    C--57924486(+) CAGCTT/GCTTCA 6 /K /Q mis12Minor allele frequency- G:0.03WA 120
    rs1880900081,2
    C--57924625(+) CTGAAA/GGAATT 3 -- int10--------
    rs1159543791,2
    F--57924691(+) TGTTTA/GTAGCA 3 -- int11Minor allele frequency- G:0.01WA 118
    rs1920785551,2
    --57924710(+) CAAGCC/TACCCT 3 -- int10--------
    rs744706471,2
    F--57924714(+) CTACCC/TTTAGA 3 -- int11Minor allele frequency- T:0.01NA 120
    rs1178462811,2
    F--57924734(+) CCACGC/GTTGGG 3 -- int11Minor allele frequency- G:0.01NA 120
    rs1844727661,2
    --57924744(+) GGTGAA/GCCCAA 3 -- int10--------
    rs733460131,2
    C,F--57924763(+) GACTCG/AAGAAT 3 -- int12Minor allele frequency- A:0.03WA 120
    rs72996311,2
    C,F,H--57925078(+) GATGGG/ATGGGA 3 -- int113Minor allele frequency- A:0.27NS EA NA WA 786

    HapMap Linkage Disequilibrium report for DCTN2 (57923885 - 57941114 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DCTN2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv724CNV Insertion18451855
    nsv819927CNV Loss19587683
    nsv899117CNV Loss21882294
    nsv899118CNV Gain21882294
    nsv428283CNV Gain18775914
    dgv513e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607376    OMIM disorders: --


    Find genes that share disorders with DCTN2           About GenesLikeMe

    1 Novoseek inferred disease relationship for DCTN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 16369996 (1)


    Export disorders for DCTN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCTN2 gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with DCTN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. (PubMed id 8647893)1, 2, 3 Echeverri C.J.... Vallee R.B. (J. Cell Biol. 1996)
    2. The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. (PubMed id 10226031)1, 2, 9 Berrueta L.... Bierer B.E. (Curr. Biol. 1999)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Protein kinase C-regulated dynamitin-macrophage-enriched myristoylated alanine-rice C kinase substrate interaction is involved in macrophage cell spreading. (PubMed id 10827182)1, 9 Yue L....Li J. (J. Biol. Chem. 2000)
    8. Dynamitin mutagenesis reveals protein-protein interactions important for dynactin structure. (PubMed id 18182012)1, 9 Maier K.C....Schroer T.A. (Traffic 2008)
    9. Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end. (PubMed id 10525537)1, 9 Eckley D.M....Schroer T.A. (J. Cell Biol. 1999)
    10. Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells. (PubMed id 16369996)1, 9 Bransfield K.L....Mighell A.J. (Mol. Carcinog. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10540 HGNC: 2712 AceView: DCTN2 Ensembl:ENSG00000175203 euGenes: HUgn10540
    ECgene: DCTN2 Kegg: 10540 H-InvDB: DCTN2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCTN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCTN2 gene:
    Search GeneIP for patents involving DCTN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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