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Aliases for DCTN2 Gene

Aliases for DCTN2 Gene

  • Dynactin 2 (P50) 2 3
  • DCTN50 3 4 6
  • 50 KDa Dynein-Associated Polypeptide 3 4
  • Dynactin Complex 50 KDa Subunit 3 4
  • P50 Dynamitin 3 4
  • 50 KD Dynein-Associated Polypeptide 3
  • Epididymis Secretory Protein Li 77 3
  • Dynactin Complex 50 KD Subunit 3
  • Dynactin Subunit 2 3
  • DYNAMITIN 3
  • HEL-S-77 3
  • DCTN-50 4
  • RBP50 3

External Ids for DCTN2 Gene

Previous GeneCards Identifiers for DCTN2 Gene

  • GC12P059194
  • GC12M058067
  • GC12M057640
  • GC12M056210
  • GC12M057924
  • GC12M054961

Summaries for DCTN2 Gene

Entrez Gene Summary for DCTN2 Gene

  • This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for DCTN2 Gene

DCTN2 (Dynactin 2 (P50)) is a Protein Coding gene. Diseases associated with DCTN2 include synucleinopathy. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include motor activity.

UniProtKB/Swiss-Prot for DCTN2 Gene

  • Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development

Gene Wiki entry for DCTN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN2 Gene

Genomics for DCTN2 Gene

Regulatory Elements for DCTN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCTN2 Gene

Start:
57,530,050 bp from pter
End:
57,547,331 bp from pter
Size:
17,282 bases
Orientation:
Minus strand

Genomic View for DCTN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCTN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN2 Gene

Proteins for DCTN2 Gene

  • Protein details for DCTN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13561-DCTN2_HUMAN
    Recommended name:
    Dynactin subunit 2
    Protein Accession:
    Q13561
    Secondary Accessions:
    • B2RBK5
    • Q86YN2
    • Q9BW17

    Protein attributes for DCTN2 Gene

    Size:
    401 amino acids
    Molecular mass:
    44231 Da
    Quaternary structure:
    • Subunit of dynactin, a multiprotein complex associated with dynein. Interacts with BICD2 and CEP135 (By similarity). Interacts with DYNAP, ECM29 and MAPRE1.
    SequenceCaution:
    • Sequence=AAO34395.1; Type=Frameshift; Positions=381; Evidence={ECO:0000305};

    Alternative splice isoforms for DCTN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTN2 Gene

Proteomics data for DCTN2 Gene at MOPED

Post-translational modifications for DCTN2 Gene

  • Ubiquitination at Lys140, Lys146, and Lys175
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for DCTN2 (Dynactin Subunit 2/DCTN2)

No data available for DME Specific Peptides for DCTN2 Gene

Domains for DCTN2 Gene

Protein Domains for DCTN2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13561

UniProtKB/Swiss-Prot:

DCTN2_HUMAN :
  • Q13561
Family:
  • Belongs to the dynactin subunit 2 family.
genes like me logo Genes that share domains with DCTN2: view

No data available for Gene Families for DCTN2 Gene

Function for DCTN2 Gene

Molecular function for DCTN2 Gene

GENATLAS Biochemistry: dynactin 2,component of a large macromolecular complex required for the cytoplasmic dynein-driven movement of organelles along microtubules,homologious to Drosophila glued
UniProtKB/Swiss-Prot Function: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development

Gene Ontology (GO) - Molecular Function for DCTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 10226031
GO:0030507 spectrin binding IDA 23704327
genes like me logo Genes that share ontologies with DCTN2: view

Phenotypes for DCTN2 Gene

genes like me logo Genes that share phenotypes with DCTN2: view

Animal Model Products

miRNA for DCTN2 Gene

miRTarBase miRNAs that target DCTN2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCTN2 Gene

Localization for DCTN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTN2 Gene COMPARTMENTS Subcellular localization image for DCTN2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
endosome 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DCTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 8647893
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol TAS --
GO:0005869 dynactin complex IDA 8647893
genes like me logo Genes that share ontologies with DCTN2: view

Pathways for DCTN2 Gene

genes like me logo Genes that share pathways with DCTN2: view

Gene Ontology (GO) - Biological Process for DCTN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0007017 microtubule-based process --
GO:0007052 mitotic spindle organization IBA --
genes like me logo Genes that share ontologies with DCTN2: view

Compounds for DCTN2 Gene

(3) Novoseek inferred chemical compound relationships for DCTN2 Gene

Compound -log(P) Hits PubMed IDs
nocodazole 76.7 2
paclitaxel 40.2 1
tyrosine 0 1
genes like me logo Genes that share compounds with DCTN2: view

Transcripts for DCTN2 Gene

Unigene Clusters for DCTN2 Gene

Dynactin 2 (p50):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12 ^
SP1: - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - - - -
SP6: - - - -
SP7:
SP8:
SP9:
SP10: - - - -
SP11: -
SP12: -
SP13:

ExUns: 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for DCTN2 Gene

GeneLoc Exon Structure for
DCTN2
ECgene alternative splicing isoforms for
DCTN2

Expression for DCTN2 Gene

mRNA expression in normal human tissues for DCTN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTN2 Gene

SOURCE GeneReport for Unigene cluster for DCTN2 Gene Hs.289123

genes like me logo Genes that share expressions with DCTN2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTN2 Gene

Orthologs for DCTN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCTN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN2 35
  • 99.83 (n)
  • 99.75 (a)
DCTN2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCTN2 35
  • 92.6 (n)
  • 96.76 (a)
DCTN2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCTN2 35
  • 91.56 (n)
  • 95.04 (a)
DCTN2 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dctn2 35
  • 89.58 (n)
  • 95.53 (a)
Dctn2 16
Dctn2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctn2 35
  • 89.44 (n)
  • 96.01 (a)
chicken
(Gallus gallus)
Aves DCTN2 35
  • 68.18 (n)
  • 67.76 (a)
DCTN2 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCTN2 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dctn2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn2 35
  • 72.21 (n)
  • 80.15 (a)
Str.13521 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10368 35
zebrafish
(Danio rerio)
Actinopterygii dctn2 35
  • 65.67 (n)
  • 69.98 (a)
dctn2 36
  • 70 (a)
OneToOne
zgc63867 35
African malaria mosquito
(Anopheles gambiae)
Insecta DCTN2_ANOGA 35
  • 48.2 (n)
  • 35.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dmn 35
  • 47.97 (n)
  • 35.23 (a)
Dmn 36
  • 34 (a)
OneToOne
Dmn 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea dnc-2 35
  • 44.35 (n)
  • 31.78 (a)
dnc-2 36
  • 24 (a)
OneToOne
Species with no ortholog for DCTN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN2 Gene

ENSEMBL:
Gene Tree for DCTN2 (if available)
TreeFam:
Gene Tree for DCTN2 (if available)

Paralogs for DCTN2 Gene

No data available for Paralogs for DCTN2 Gene

Variants for DCTN2 Gene

Sequence variations from dbSNP and Humsavar for DCTN2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14931 -- 57,532,784(-) GCAAA(A/G)GTGAG synonymous-codon, reference
rs703837 -- 57,532,689(+) TTCCA(A/G)AGTCC intron-variant
rs703838 -- 57,533,732(+) CGCCA(C/G)TGCAC intron-variant
rs703839 -- 57,539,897(-) AGGCG(C/T)CCACC intron-variant
rs703840 -- 57,540,402(-) CATCA(A/T)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN2 Gene

Variant ID Type Subtype PubMed ID
nsv899117 CNV Loss 21882294
nsv899118 CNV Gain 21882294
dgv513e1 CNV Complex 17122850
nsv428283 CNV Gain 18775914
nsv724 CNV Insertion 18451855
nsv819927 CNV Loss 19587683

Relevant External Links for DCTN2 Gene

HapMap Linkage Disequilibrium report
DCTN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN2 Gene

Disorders for DCTN2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DCTN2 Gene including...

Search for DCTN2 Gene in MalaCards »

(1) Novoseek inferred disease relationships for DCTN2 Gene

Disease -log(P) Hits PubMed IDs
cancer 0 1
genes like me logo Genes that share disorders with DCTN2: view

No data available for UniProtKB/Swiss-Prot for DCTN2 Gene

Publications for DCTN2 Gene

  1. The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. (PMID: 10226031) Berrueta L. … Bierer B.E. (Curr. Biol. 1999) 3 4 23
  2. Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. (PMID: 8647893) Echeverri C.J. … Vallee R.B. (J. Cell Biol. 1996) 2 3 4
  3. RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. (PMID: 16043481) Khanna H. … Swaroop A. (J. Biol. Chem. 2005) 3 23
  4. Intracellular transport of human immunodeficiency virus type 1 genomic RNA and viral production are dependent on dynein motor function and late endosome positioning. (PMID: 19286658) Lehmann M. … Mouland A.J. (J. Biol. Chem. 2009) 3 23
  5. Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells. (PMID: 16369996) Bransfield K.L. … Mighell A.J. (Mol. Carcinog. 2006) 3 23

Products for DCTN2 Gene

  • Addgene plasmids for DCTN2

Sources for DCTN2 Gene

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