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Aliases for DCTN1 Gene

Aliases for DCTN1 Gene

  • Dynactin 1 2 3
  • 150 KDa Dynein-Associated Polypeptide 3 4
  • DAP-150 3 4
  • DP-150 3 4
  • P135 3 4
  • Dynactin 1 (P150, Glued (Drosophila) Homolog) 2
  • Dynactin 1 (P150, Glued Homolog, Drosophila) 3
  • P150 Glued Homolog (Drosophila) 2
  • Dynactin Subunit 1 3
  • P150-Glued 4
  • HMN7B 6

External Ids for DCTN1 Gene

Previous GeneCards Identifiers for DCTN1 Gene

  • GC02M074577
  • GC02M074652
  • GC02M074396
  • GC02M074413
  • GC02M074562
  • GC02M074350
  • GC02M074499
  • GC02M074441
  • GC02M074588

Summaries for DCTN1 Gene

Entrez Gene Summary for DCTN1 Gene

  • This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008]

GeneCards Summary for DCTN1 Gene

DCTN1 (Dynactin 1) is a Protein Coding gene. Diseases associated with DCTN1 include perry syndrome and neuropathy, distal hereditary motor, type viib. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include motor activity. An important paralog of this gene is CLIP4.

UniProtKB/Swiss-Prot for DCTN1 Gene

  • Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles

Gene Wiki entry for DCTN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN1 Gene

Genomics for DCTN1 Gene

Regulatory Elements for DCTN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCTN1 Gene

74,361,154 bp from pter
74,392,087 bp from pter
30,934 bases
Minus strand

Genomic View for DCTN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN1 Gene

Proteins for DCTN1 Gene

  • Protein details for DCTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynactin subunit 1
    Protein Accession:
    Secondary Accessions:
    • A8MY36
    • B4DM45
    • E9PFS5
    • E9PGE1
    • G5E9H4
    • O95296
    • Q6IQ37
    • Q9BRM9
    • Q9UIU1
    • Q9UIU2

    Protein attributes for DCTN1 Gene

    1278 amino acids
    Molecular mass:
    141695 Da
    Quaternary structure:
    • Large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3. Interacts (via C-terminus) with SNX6. Interacts with CLIP1, CLN3, DYNAP, ECM29 and FBXL5. Interacts with MISP; this interaction regulates its distribution at the cell cortex. Interacts with CEP131. Interacts with KIAA1377 (PubMed:24867236).

    Three dimensional structures from OCA and Proteopedia for DCTN1 Gene

    Alternative splice isoforms for DCTN1 Gene

neXtProt entry for DCTN1 Gene

Proteomics data for DCTN1 Gene at MOPED

Post-translational modifications for DCTN1 Gene

  • Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
  • Ubiquitination at Lys1133, Lys1151, Lys1179, Lys1193, and Lys1235
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for DCTN1 (Dynactin Subunit 1/DCTN1)

No data available for DME Specific Peptides for DCTN1 Gene

Domains for DCTN1 Gene

Gene Families for DCTN1 Gene

Protein Domains for DCTN1 Gene


Suggested Antigen Peptide Sequences for DCTN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CAP-Gly domain.
  • Belongs to the dynactin 150 kDa subunit family.
  • Contains 1 CAP-Gly domain.
  • Belongs to the dynactin 150 kDa subunit family.
genes like me logo Genes that share domains with DCTN1: view

Function for DCTN1 Gene

Molecular function for DCTN1 Gene

GENATLAS Biochemistry:
dynactin 1,component of a large macromolecular complex required for the cytoplasmic dynein-driven movement of organelles along microtubules,homologous to Drosophila glued
UniProtKB/Swiss-Prot Function:
Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles

Gene Ontology (GO) - Molecular Function for DCTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
GO:0005515 protein binding IPI 15107855
GO:0016740 transferase activity --
GO:0045502 dynein binding IEA --
GO:0048037 cofactor binding --
genes like me logo Genes that share ontologies with DCTN1: view

Phenotypes for DCTN1 Gene

genes like me logo Genes that share phenotypes with DCTN1: view

Animal Models for DCTN1 Gene

MGI Knock Outs for DCTN1:

miRNA for DCTN1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DCTN1 Gene

Localization for DCTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.

Subcellular locations from

Jensen Localization Image for DCTN1 Gene COMPARTMENTS Subcellular localization image for DCTN1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 3
endosome 2
golgi apparatus 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DCTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 19468067
GO:0000922 spindle pole IDA 14718566
GO:0005737 cytoplasm TAS 1828535
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCTN1: view

Pathways for DCTN1 Gene

genes like me logo Genes that share pathways with DCTN1: view

Pathways by source for DCTN1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DCTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006987 activation of signaling protein activity involved in unfolded protein response --
GO:0006996 organelle organization TAS --
GO:0007067 mitotic nuclear division NAS 1828535
genes like me logo Genes that share ontologies with DCTN1: view

Drugs for DCTN1 Gene

(1) Novoseek inferred chemical compound relationships for DCTN1 Gene

Compound -log(P) Hits PubMed IDs
glutamine 9.75 1
genes like me logo Genes that share compounds with DCTN1: view

Transcripts for DCTN1 Gene

Unigene Clusters for DCTN1 Gene

Dynactin 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN1 Gene

No ASD Table

Relevant External Links for DCTN1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCTN1 Gene

mRNA expression in normal human tissues for DCTN1 Gene

Protein differential expression in normal tissues for DCTN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.7) and Frontal cortex (6.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTN1 Gene

SOURCE GeneReport for Unigene cluster for DCTN1 Gene Hs.516111

mRNA Expression by UniProt/SwissProt for DCTN1 Gene

Tissue specificity: Brain
genes like me logo Genes that share expressions with DCTN1: view

Expression partners for DCTN1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DCTN1 Gene

Orthologs for DCTN1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCTN1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCTN1 35
  • 91.29 (n)
  • 96.04 (a)
DCTN1 36
  • 96 (a)
(Canis familiaris)
Mammalia DCTN1 35
  • 92.43 (n)
  • 98.11 (a)
DCTN1 36
  • 98 (a)
(Mus musculus)
Mammalia Dctn1 35
  • 90.01 (n)
  • 97.1 (a)
Dctn1 16
Dctn1 36
  • 97 (a)
(Pan troglodytes)
Mammalia DCTN1 35
  • 99.66 (n)
  • 99.84 (a)
DCTN1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dctn1 35
  • 89.98 (n)
  • 96.55 (a)
(Monodelphis domestica)
Mammalia DCTN1 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia DCTN1 36
  • 73 (a)
(Gallus gallus)
Aves DCTN1 35
  • 75.38 (n)
  • 81.34 (a)
DCTN1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia DCTN1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn1 35
  • 74.97 (n)
  • 78.59 (a)
Str.6794 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68950 35
(Danio rerio)
Actinopterygii dctn1b 35
  • 71.02 (n)
  • 75.88 (a)
dctn1a 36
  • 72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9279 37
  • 27 (a)
Gl 37
  • 33 (a)
Gl 35
  • 46.78 (n)
  • 36.37 (a)
CG9279 36
  • 26 (a)
Gl 36
  • 34 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004194 35
  • 49.2 (n)
  • 39.03 (a)
(Caenorhabditis elegans)
Secernentea dnc-1 37
  • 28 (a)
dnc-1 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP100 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for DCTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN1 Gene

Gene Tree for DCTN1 (if available)
Gene Tree for DCTN1 (if available)

Paralogs for DCTN1 Gene

Paralogs for DCTN1 Gene

genes like me logo Genes that share paralogs with DCTN1: view

Variants for DCTN1 Gene

Sequence variations from dbSNP and Humsavar for DCTN1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs740277 -- 74,370,400(-) CCCAT(C/T)GCCAG intron-variant
rs741788 -- 74,361,892(+) ACTGT(A/G)AGCAC intron-variant
rs755762 -- 74,376,582(-) AAGGG(G/T)GCAAG intron-variant, upstream-variant-2KB
rs909175 -- 74,369,003(-) TGTGT(C/G)GTGGT intron-variant
rs909176 -- 74,368,320(-) CCTCA(C/G)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN1 Gene

Variant ID Type Subtype PubMed ID
nsv834261 CNV Loss 17160897
dgv1199e1 CNV Complex 17122850
nsv874287 CNV Loss 21882294
esv25070 CNV Gain 19812545
nsv2784 CNV Loss 18451855
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294
nsv820134 CNV Loss 19587683

Relevant External Links for DCTN1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN1 Gene

Disorders for DCTN1 Gene

(3) OMIM Diseases for DCTN1 Gene (601143)


  • Neuronopathy, distal hereditary motor, 7B (HMN7B) [MIM:607641]: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. {ECO:0000269 PubMed:12627231}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Amyotrophic lateral sclerosis (ALS) [MIM:105400]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:15326253, ECO:0000269 PubMed:16240349}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Perry syndrome (PERRYS) [MIM:168605]: A neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally. {ECO:0000269 PubMed:19136952, ECO:0000269 PubMed:24676999, ECO:0000269 PubMed:24881494}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for DCTN1 Gene

(5) Novoseek inferred disease relationships for DCTN1 Gene

Disease -log(P) Hits PubMed IDs
miyoshi myopathy 73.8 1
amyotrophic lateral sclerosis 68.9 4
motor neuron disease 68.4 1
neurodegeneration 51 5
neuromuscular diseases 32 2

Relevant External Links for DCTN1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DCTN1: view

No data available for Genatlas for DCTN1 Gene

Publications for DCTN1 Gene

  1. Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS. (PMID: 15326253) Muench C. … Ludolph A.C. (Neurology 2004) 3 4 23 48
  2. Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization. (PMID: 8838327) Holzbaur E.L.F. … Tokito M.K. (Genomics 1996) 3 4 23
  3. Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD. (PMID: 16240349) Muench C. … Ludolph A.C. (Ann. Neurol. 2005) 3 4 23
  4. A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation. (PMID: 16505168) Levy J.R. … Holzbaur E.L.F. (J. Cell Biol. 2006) 3 4 23
  5. FBXL5 interacts with p150Glued and regulates its ubiquitination. (PMID: 17532294) Zhang N. … Yao X. (Biochem. Biophys. Res. Commun. 2007) 3 4 23

Products for DCTN1 Gene

Sources for DCTN1 Gene

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