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Aliases for DCTD Gene

Aliases for DCTD Gene

  • DCMP Deaminase 2 3 4
  • EC 3.5.4.12 4 64

External Ids for DCTD Gene

Summaries for DCTD Gene

Entrez Gene Summary for DCTD Gene

  • The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCTD Gene

DCTD (DCMP Deaminase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism.

UniProtKB/Swiss-Prot for DCTD Gene

  • Supplies the nucleotide substrate for thymidylate synthetase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTD Gene

Genomics for DCTD Gene

Genomic Location for DCTD Gene

Start:
182,890,060 bp from pter
End:
182,917,936 bp from pter
Size:
27,877 bases
Orientation:
Minus strand

Genomic View for DCTD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCTD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTD Gene

Regulatory Elements for DCTD Gene

Proteins for DCTD Gene

  • Protein details for DCTD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32321-DCTD_HUMAN
    Recommended name:
    Deoxycytidylate deaminase
    Protein Accession:
    P32321
    Secondary Accessions:
    • B2R836
    • D3DP49
    • D3DP50
    • Q5M7Z8
    • Q9BVD8

    Protein attributes for DCTD Gene

    Size:
    178 amino acids
    Molecular mass:
    20016 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for DCTD Gene

    Alternative splice isoforms for DCTD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTD Gene

Proteomics data for DCTD Gene at MOPED

Selected DME Specific Peptides for DCTD Gene

Post-translational modifications for DCTD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for DCTD Gene

UniProtKB/Swiss-Prot:

DCTD_HUMAN
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.:
    • P32321
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.:
    • P32321
genes like me logo Genes that share domains with DCTD: view

No data available for Gene Families for DCTD Gene

Function for DCTD Gene

Molecular function for DCTD Gene

UniProtKB/Swiss-Prot CatalyticActivity: dCMP + H(2)O = dUMP + NH(3)
UniProtKB/Swiss-Prot EnzymeRegulation: Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP
UniProtKB/Swiss-Prot Function: Supplies the nucleotide substrate for thymidylate synthetase

Enzyme Numbers (IUBMB) for DCTD Gene

Gene Ontology (GO) - Molecular Function for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004132 dCMP deaminase activity EXP --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with DCTD: view

Phenotypes for DCTD Gene

GenomeRNAi human phenotypes for DCTD:
genes like me logo Genes that share phenotypes with DCTD: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for DCTD Gene

Localization for DCTD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTD Gene COMPARTMENTS Subcellular localization image for DCTD gene
Compartment Confidence
cytosol 4
extracellular 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DCTD: view

Pathways for DCTD Gene

genes like me logo Genes that share pathways with DCTD: view

Pathways by source for DCTD Gene

Gene Ontology (GO) - Biological Process for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0006220 pyrimidine nucleotide metabolic process IEA --
GO:0008152 metabolic process --
GO:0009165 nucleotide biosynthetic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with DCTD: view

Compounds for DCTD Gene

(4) HMDB Compounds for DCTD Gene

Compound Synonyms Cas Number PubMed IDs
Ammonia
  • NH3
7664-41-7
dCMP
  • 2'-Deoxycytidine 5'-monophosphate
1032-65-1
dUMP
  • 2'-Deoxy-5'-uridylate
964-26-1
Water
  • Dihydrogen oxide
7732-18-5

(18) Novoseek inferred chemical compound relationships for DCTD Gene

Compound -log(P) Hits PubMed IDs
dcmp 96.4 42
tetrahydrouridine 92.6 1
deoxycytidine 88.9 8
ara-ctp 87.5 3
dctp 87 6
genes like me logo Genes that share compounds with DCTD: view

Transcripts for DCTD Gene

Unigene Clusters for DCTD Gene

DCMP deaminase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCTD Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - - - -
SP9: - - -
SP10: - - -
SP11:
SP12:
SP13:

ExUns: 11 ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for DCTD Gene

GeneLoc Exon Structure for
DCTD
ECgene alternative splicing isoforms for
DCTD

Expression for DCTD Gene

mRNA expression in normal human tissues for DCTD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTD Gene

SOURCE GeneReport for Unigene cluster for DCTD Gene Hs.183850

genes like me logo Genes that share expressions with DCTD: view

Orthologs for DCTD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCTD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTD 36
  • 97 (n)
  • 96.3 (a)
DCTD 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCTD 36
  • 87.64 (n)
  • 92.7 (a)
DCTD 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCTD 37
  • 61 (a)
OneToOne
LOC607328 36
  • 88.26 (n)
  • 90.57 (a)
mouse
(Mus musculus)
Mammalia Dctd 36
  • 86.67 (n)
  • 92.78 (a)
Dctd 16
Dctd 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCTD 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCTD 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctd 36
  • 86.11 (n)
  • 92.78 (a)
chicken
(Gallus gallus)
Aves DCTD 36
  • 78.41 (n)
  • 86.36 (a)
DCTD 37
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCTD 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8134 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dctd 36
  • 76.86 (n)
  • 84.12 (a)
Str.8923 36
zebrafish
(Danio rerio)
Actinopterygii dctd 36
  • 74.07 (n)
  • 81.87 (a)
dctd 37
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008158 36
  • 63.73 (n)
  • 63.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6951 36
  • 58.23 (n)
  • 53.09 (a)
CG6951 37
  • 44 (a)
OneToOne
CG6951 38
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK643.2 37
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCD1 37
  • 14 (a)
OneToOne
DCD1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G48540 36
  • 54.83 (n)
  • 55.03 (a)
rice
(Oryza sativa)
Liliopsida Os01g0765000 36
  • 53.41 (n)
  • 53.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 65 (a)
OneToOne
Species with no ortholog for DCTD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTD Gene

ENSEMBL:
Gene Tree for DCTD (if available)
TreeFam:
Gene Tree for DCTD (if available)

Paralogs for DCTD Gene

No data available for Paralogs for DCTD Gene

Variants for DCTD Gene

Sequence variations from dbSNP and Humsavar for DCTD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs851 -- 182,890,517(-) AACGC(A/G)GTTCA utr-variant-3-prime
rs978 -- 182,890,525(-) CGCAT(A/G)CCAAC utr-variant-3-prime
rs4742 -- 182,894,535(-) TATGT(A/C/G/T)GCCTT synonymous-codon, reference
rs7277 -- 182,890,360(-) CACAA(A/G)CATCA utr-variant-3-prime
rs7278 -- 182,890,334(-) CGGGG(C/T)GGGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DCTD Gene

Variant ID Type Subtype PubMed ID
nsv881410 CNV Loss 21882294
esv24217 CNV Loss 19812545

Relevant External Links for DCTD Gene

HapMap Linkage Disequilibrium report
DCTD
Human Gene Mutation Database (HGMD)
DCTD

Disorders for DCTD Gene

(4) Novoseek inferred disease relationships for DCTD Gene

Disease -log(P) Hits PubMed IDs
leukemia 28.8 1
tumors 0 3
cancer 0 1
immunodeficiency 0 1

Relevant External Links for DCTD

Genetic Association Database (GAD)
DCTD
Human Genome Epidemiology (HuGE) Navigator
DCTD
genes like me logo Genes that share disorders with DCTD: view

No data available for UniProtKB/Swiss-Prot for DCTD Gene

Publications for DCTD Gene

  1. Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. (PMID: 7642519) Weiner K.X. … Maley G.F. (J. Biol. Chem. 1995) 3 4 23
  2. Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. (PMID: 7685356) Weiner K.X. … Maley G.F. (J. Biol. Chem. 1993) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. (PMID: 17602053) Rha S.Y. … Chung H.C. (Oncologist 2007) 3 49
  5. Properties of an affinity-column-purified human deoxycytidylate deaminase. (PMID: 8448179) Maley G.F. … Maley F. (Biochim. Biophys. Acta 1993) 3 23

Products for DCTD Gene

Sources for DCTD Gene

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