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Aliases for DCTD Gene

Aliases for DCTD Gene

  • DCMP Deaminase 2 3 4 5
  • EC 3.5.4.12 4 61

External Ids for DCTD Gene

Previous GeneCards Identifiers for DCTD Gene

  • GC04M184830
  • GC04M184491
  • GC04M184507
  • GC04M184186
  • GC04M184048
  • GC04M183811
  • GC04M179572

Summaries for DCTD Gene

Entrez Gene Summary for DCTD Gene

  • The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCTD Gene

DCTD (DCMP Deaminase) is a Protein Coding gene. Diseases associated with DCTD include Glass Syndrome. Among its related pathways are Metabolism and Gemcitabine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include hydrolase activity and dCMP deaminase activity.

UniProtKB/Swiss-Prot for DCTD Gene

  • Supplies the nucleotide substrate for thymidylate synthetase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTD Gene

Genomics for DCTD Gene

Regulatory Elements for DCTD Gene

Enhancers for DCTD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F182895 0.5 ENCODE 17.4 +22.0 21996 0.9 ELF3 ATF1 MLX ARID4B DMAP1 ZNF48 ZSCAN9 RAD21 RARA YY1 DCTD ENSG00000272646
GH04F182879 0.9 Ensembl ENCODE 16.7 +36.8 36764 2.4 ELF3 TBP ATF1 MLX ZFP64 ARID4B DMAP1 THRB RAD21 RARA DCTD GC04P182881 LOC105377576
GH04F182915 0.6 ENCODE 15.4 +0.0 16 3.9 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 SIN3A ARID4B DMAP1 ZNF2 ZNF48 CDKN2AIP DCTD RNU6-1053P ENSG00000272646
GH04F182922 1.1 Ensembl ENCODE 14.6 -5.5 -5483 2.8 RFX1 SCRT2 BHLHE40 HMBOX1 FOS ATF2 NR2F2 DCTD LOC105377577
GH04F182916 0.2 ENCODE 13.9 +2.6 2592 0.0 DCTD ENSG00000272646
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DCTD on UCSC Golden Path with GeneCards custom track

Promoters for DCTD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001255368 436 1801 ATF1 CREB3L1 WRNIP1 SIN3A ARID4B DMAP1 ZNF48 GLIS2 ELK1 ZNF143

Genomic Location for DCTD Gene

Chromosome:
4
Start:
182,890,060 bp from pter
End:
182,917,936 bp from pter
Size:
27,877 bases
Orientation:
Minus strand

Genomic View for DCTD Gene

Genes around DCTD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTD Gene

Proteins for DCTD Gene

  • Protein details for DCTD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32321-DCTD_HUMAN
    Recommended name:
    Deoxycytidylate deaminase
    Protein Accession:
    P32321
    Secondary Accessions:
    • B2R836
    • D3DP49
    • D3DP50
    • Q5M7Z8
    • Q9BVD8

    Protein attributes for DCTD Gene

    Size:
    178 amino acids
    Molecular mass:
    20016 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for DCTD Gene

    Alternative splice isoforms for DCTD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTD Gene

Selected DME Specific Peptides for DCTD Gene

Post-translational modifications for DCTD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DCTD Gene

Suggested Antigen Peptide Sequences for DCTD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32321

UniProtKB/Swiss-Prot:

DCTD_HUMAN :
  • Contains 1 CMP/dCMP-type deaminase domain.
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with DCTD: view

No data available for Gene Families for DCTD Gene

Function for DCTD Gene

Molecular function for DCTD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
dCMP + H(2)O = dUMP + NH(3).
UniProtKB/Swiss-Prot EnzymeRegulation:
Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.
UniProtKB/Swiss-Prot Function:
Supplies the nucleotide substrate for thymidylate synthetase.

Enzyme Numbers (IUBMB) for DCTD Gene

Gene Ontology (GO) - Molecular Function for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004132 dCMP deaminase activity EXP,IEA 8448179
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0042802 identical protein binding IPI 16189514
genes like me logo Genes that share ontologies with DCTD: view
genes like me logo Genes that share phenotypes with DCTD: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DCTD

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTD Gene

Localization for DCTD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTD Gene COMPARTMENTS Subcellular localization image for DCTD gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DCTD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCTD Gene

Pathways & Interactions for DCTD Gene

genes like me logo Genes that share pathways with DCTD: view

Pathways by source for DCTD Gene

Gene Ontology (GO) - Biological Process for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006220 pyrimidine nucleotide metabolic process IEA,TAS 7685356
GO:0006226 dUMP biosynthetic process IBA --
GO:0006231 dTMP biosynthetic process IBA --
GO:0008152 metabolic process IEA --
GO:0009165 nucleotide biosynthetic process IEA --
genes like me logo Genes that share ontologies with DCTD: view

No data available for SIGNOR curated interactions for DCTD Gene

Drugs & Compounds for DCTD Gene

(11) Drugs for DCTD Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma Enzyme, substrate 1093
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1974
Water Approved Pharma 0
dCMP Experimental Pharma 0

(11) Additional Compounds for DCTD Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
dUMP
  • 2'-Deoxy-5'-uridylate
  • 2'-Deoxy-5'-uridylic acid
  • 2'-Deoxyuridine 5'-monophosphate
  • 2'-Deoxyuridine 5'-phosphate
  • 2'-Deoxyuridylate
964-26-1
genes like me logo Genes that share compounds with DCTD: view

Transcripts for DCTD Gene

Unigene Clusters for DCTD Gene

DCMP deaminase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTD Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - - - -
SP9: - - -
SP10: - - -
SP11:
SP12:
SP13:

ExUns: 11 ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for DCTD Gene

GeneLoc Exon Structure for
DCTD
ECgene alternative splicing isoforms for
DCTD

Expression for DCTD Gene

mRNA expression in normal human tissues for DCTD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCTD Gene



Protein tissue co-expression partners for DCTD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTD Gene:

DCTD

SOURCE GeneReport for Unigene cluster for DCTD Gene:

Hs.183850
genes like me logo Genes that share expression patterns with DCTD: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTD Gene

Orthologs for DCTD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCTD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTD 34 35
  • 97 (n)
dog
(Canis familiaris)
Mammalia LOC607328 34
  • 88.26 (n)
DCTD 35
  • 61 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCTD 34 35
  • 87.64 (n)
mouse
(Mus musculus)
Mammalia Dctd 34 16 35
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia Dctd 34
  • 86.11 (n)
oppossum
(Monodelphis domestica)
Mammalia DCTD 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCTD 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCTD 34 35
  • 78.41 (n)
lizard
(Anolis carolinensis)
Reptilia DCTD 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctd 34
  • 76.86 (n)
Str.8923 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8134 34
zebrafish
(Danio rerio)
Actinopterygii dctd 34 35
  • 74.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008158 34
  • 63.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6951 36 34 35
  • 58.23 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK643.2 35
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCD1 35 37
  • 14 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G48540 34
  • 54.83 (n)
rice
(Oryza sativa)
Liliopsida Os01g0765000 34
  • 53.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 65 (a)
OneToOne
Species where no ortholog for DCTD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTD Gene

ENSEMBL:
Gene Tree for DCTD (if available)
TreeFam:
Gene Tree for DCTD (if available)

Paralogs for DCTD Gene

No data available for Paralogs for DCTD Gene

Variants for DCTD Gene

Sequence variations from dbSNP and Humsavar for DCTD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10001362 -- 182,893,669(+) CTCTG(A/C)AGGCA intron-variant
rs10009825 -- 182,901,439(+) ACCTG(A/C)GGGTT intron-variant
rs10016530 -- 182,903,831(+) TGTCC(A/C)CAACC intron-variant
rs10017797 -- 182,891,730(+) TTGGG(G/T)AGTCA intron-variant
rs10520543 -- 182,901,076(+) TCAGC(A/G)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCTD Gene

Variant ID Type Subtype PubMed ID
esv24217 CNV loss 19812545
esv2763419 CNV loss 21179565
nsv1016376 CNV gain 25217958
nsv1122094 CNV deletion 24896259
nsv949856 CNV deletion 24416366

Variation tolerance for DCTD Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTD Gene

Human Gene Mutation Database (HGMD)
DCTD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCTD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTD Gene

Disorders for DCTD Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCTD Gene - From: DISEASES

Disorder Aliases PubMed IDs
glass syndrome
  • chromosome 2q32-q33 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DCTD in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCTD

Genetic Association Database (GAD)
DCTD
Human Genome Epidemiology (HuGE) Navigator
DCTD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTD
genes like me logo Genes that share disorders with DCTD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCTD Gene

Publications for DCTD Gene

  1. Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. (PMID: 7642519) Weiner K.X. … Maley G.F. (J. Biol. Chem. 1995) 3 4 22 64
  2. Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. (PMID: 7685356) Weiner K.X. … Maley G.F. (J. Biol. Chem. 1993) 3 4 22 64
  3. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PMID: 20028759) Okazaki T. … Li D. (Clin. Cancer Res. 2010) 3 46 64
  4. Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. (PMID: 20665488) Tanaka M. … Li D. (Cancer 2010) 3 46 64
  5. Genetic factors influencing cytarabine therapy. (PMID: 19842938) Lamba J.K. (Pharmacogenomics 2009) 22 25 64

Products for DCTD Gene

Sources for DCTD Gene

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