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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCTD Gene

protein-coding   GIFtS: 66
GCID: GC04M183811

DCMP Deaminase

Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DCMP Deaminase1 2 3
EC 3.5.4.123 8
Deoxycytidylate Deaminase2

External Ids:    HGNC: 27101   Entrez Gene: 16352   Ensembl: ENSG000001291877   OMIM: 6076385   UniProtKB: P323213   

Export aliases for DCTD gene to outside databases

Previous GC identifers: GC04M184830 GC04M184491 GC04M184507 GC04M184186 GC04M184048 GC04M179572


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DCTD Gene:
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for
thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found
as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DCTD Gene: 
DCTD (dCMP deaminase) is a protein-coding gene. Diseases associated with DCTD include lymphosarcoma, and biliary tract cancer, and among its related super-pathways are Metabolic pathways and pyrimidine deoxyribonucleotides de novo biosynthesis I. GO annotations related to this gene include zinc ion binding.

UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321
Function: Supplies the nucleotide substrate for thymidylate synthetase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCTD gene promoter:
         HFH-3   NF-1/L   STAT1   AML1a   HTF   STAT1beta   STAT1alpha   FOXI1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCTD promoter sequence
   Search SABiosciences Chromatin IP Primers for DCTD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCTD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

DCTD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTD gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M183811:  view genomic region     (about GC identifiers)

Start:
183,811,213 bp from pter      End:
183,839,089 bp from pter
Size:
27,877 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321 (See protein sequence)
Recommended Name: Deoxycytidylate deaminase  
Size: 178 amino acids; 20016 Da
Cofactor: Zinc
Subunit: Homohexamer
1 PDB 3D structure from and Proteopedia for DCTD:
2W4L (3D)    
Secondary accessions: B2R836 D3DP49 D3DP50 Q5M7Z8 Q9BVD8
Alternative splicing: 2 isoforms:  P32321-1   P32321-2   

Explore the universe of human proteins at neXtProt for DCTD: NX_P32321

Explore proteomics data for DCTD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P32321

  • 3 DME Specific Peptides for DCTD (P32321)
     QVGACIV  LPWRRTA  LFPCNECAKLIIQ 

    DCTD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCTD Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001012750.1  NP_001912.2  

    ENSEMBL proteins: 
     ENSP00000425462   ENSP00000349576   ENSP00000422386   ENSP00000398194   ENSP00000425287  
     ENSP00000424017   ENSP00000422662   ENSP00000424050   ENSP00000423182   ENSP00000423894  
     ENSP00000425904   ENSP00000421792   ENSP00000423498   ENSP00000427470   ENSP00000422729  
     ENSP00000427282  
    Reactome Protein details: P32321
    Human Recombinant Protein Products for DCTD: 
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    Cloud-Clone Corp. Proteins for DCTD 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    DCTD for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR002125 CMP_dCMP_Zn-bd
     IPR016473 dCMP_deaminase
     IPR016193 Cytidine_deaminase-like
     IPR015517 Cyt_deaminase

    Graphical View of Domain Structure for InterPro Entry P32321

    ProtoNet protein and cluster: P32321

    1 Blocks protein domain: IPB002125 Cytidine/deoxycytidylate deaminase

    UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family


    DCTD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCTD_HUMAN, P32321
    Function: Supplies the nucleotide substrate for thymidylate synthetase
    Catalytic activity: dCMP + H(2)O = dUMP + NH(3)
    Enzyme regulation: Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic
    pathway, dCTP and dTTP

         Enzyme Number (IUBMB): EC 3.5.4.121 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004132dCMP deaminase activity EXP--
    GO:0008270zinc ion binding IEA--
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
         
    DCTD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DCTD:
     Increased cell death HMECs cel 

         1 MGI phenotypic allele for Dctd (no phenotypes)

    DCTD for phenotypes           About GeneDecksing

    Animal Models:
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    miRTarBase miRNAs that target DCTD:
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    hsa-miR-411* hsa-miR-485-5p hsa-miR-3910 hsa-miR-3607-5p hsa-miR-379* hsa-miR-944 hsa-miR-488 hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidDCTD 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DCTD About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
    pyrimidine deoxyribonucleotides biosynthesis from CTP0.88
    3Pyrimidine metabolism
    Pyrimidine metabolism0.50
    4Purine metabolism
    Metabolism of nucleotides0.42
    5Purine metabolism
    Pyrimidine metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DCTD
        pyrimidine deoxyribonucleotides biosynthesis from CTP


    4        Reactome Pathways for DCTD
        Metabolism of nucleotides
    Metabolism
    Pyrimidine metabolism
    Pyrimidine biosynthesis


    2         Kegg Pathways  (Kegg details for DCTD):
        Pyrimidine metabolism
    Metabolic pathways


    DCTD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCTD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/24 Interacting proteins for DCTD (P323212, 3 ENSP000003495764) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP76Q8TAP62, 3, ENSP000002621274MINT-66933 I2D: score=5 STRING: ENSP00000262127
    LNX1Q8TBB12, 3, ENSP000002639254MINT-66043 I2D: score=5 STRING: ENSP00000263925
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-68250 I2D: score=5 STRING: ENSP00000386394
    NUDT18Q6ZVK82, 3, ENSP000003078524MINT-67667 I2D: score=5 STRING: ENSP00000307852
    ZNF764Q96H863I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006220pyrimidine nucleotide metabolic process TAS7685356
    GO:0009165nucleotide biosynthetic process IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0046134pyrimidine nucleoside biosynthetic process TAS--

    DCTD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DCTD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCTD

    4 HMDB Compounds for DCTD    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    dCMP2'-Deoxycytidine 5'-monophosphate (see all 12)1032-65-1--
    dUMP2'-Deoxy-5'-uridylate (see all 12)964-26-1--

    10/18 Novoseek inferred chemical compound relationships for DCTD gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dcmp 96.4 49 12488542 (5), 12771412 (3), 7685356 (3), 8448179 (3) (see all 25)
    tetrahydrouridine 92.6 1 11697326 (1)
    deoxycytidine 88.9 9 11697326 (1), 12019082 (1), 8226747 (1), 19531250 (1) (see all 8)
    ara-ctp 87.5 3 1780754 (1), 19842938 (1), 9680112 (1)
    dctp 87 7 12488542 (1), 9988115 (1), 18255096 (1), 8448179 (1) (see all 6)
    dttp 85.5 7 8448179 (1), 2232889 (1), 8117667 (1), 15520873 (1)
    cytidine 82.9 11 10497201 (1), 16551864 (1), 19531250 (1), 18255096 (1) (see all 9)
    dichloromethane 82.1 24 12488542 (2), 7642519 (2), 1449536 (2), 8448179 (2) (see all 18)
    zebularine 79 2 12771412 (1), 8583252 (1)
    thymidylate 75.5 5 8798492 (1), 17416930 (1), 15992031 (1), 2247612 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about DCTD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCTD gene (2 alternative transcripts): 
    NM_001012732.1  NM_001921.2  

    Unigene Cluster for DCTD:

    DCMP deaminase
    Hs.183850  [show with all ESTs]
    Unigene Representative Sequence: NM_001012732
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500813(uc010irw.3 uc003ivh.3) ENST00000357067(uc003ivf.3 uc003ivg.3)
    ENST00000507543 ENST00000438320 ENST00000507631 ENST00000510370 ENST00000503182
    ENST00000510307 ENST00000512766 ENST00000514754 ENST00000513383 ENST00000513348
    ENST00000503820 ENST00000509757 ENST00000509218 ENST00000503988 ENST00000508994

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK293135.1 AK310788.1 AK313221.1 BC001286.1 BC088357.1 L12136.1 

    22 DOTS entries:

    DT.447710  DT.97852127  DT.92445882  DT.100823701  DT.100823692  DT.100823699  DT.92445880  DT.100009520 
    DT.92445881  DT.100823694  DT.100823695  DT.121226583  DT.97852126  DT.100823690  DT.95154826  DT.100029197 
    DT.100823693  DT.91846060  DT.92445890  DT.95154840  DT.121226595  DT.92015862 

    24/381 AceView cDNA sequences (see all 381):

    BM309913 BQ007899 CA431426 CR604027 AU121520 AW301176 BU963618 BQ946562 
    BU625771 BP353941 BM700396 BP378968 CA421632 T55740 BM662463 CR615419 
    BU615634 BM930047 BG656447 BI835533 AI362775 BQ002587 BU625871 H30279 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DCTD (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^
    SP1:        -     -     -     -     -     -     -     -     -     -     -     -                                                                                 
    SP2:                                -     -     -     -     -     -     -     -                                                                                 
    SP3:                                      -     -     -     -     -     -     -                                                                                 
    SP4:                                                                          -                                                                                 
    SP5:                                -     -     -     -     -     -     -     -           -     -                                                               

    ExUns: 11 ^ 12
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for DCTD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCTD expression in normal human tissues (normalized intensities)      DCTD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTTTATT
    DCTD Expression
    About this image


    DCTD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             brain/midbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium   

    See DCTD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCTD

    SOURCE GeneReport for Unigene cluster: Hs.183850
        SABiosciences Custom PCR Arrays for DCTD
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCTD gene from 10/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dctd1 , 5 dCMP deaminase1, 5 86.67(n)1
    92.78(a)1
      8 (26.98 cM)5
    3206851  NM_001161515.11  NP_001154987.11 
     480990925 
    chicken
    (Gallus gallus)
    Aves DCTD1 dCMP deaminase 78.41(n)
    86.36(a)
      422556  NM_001006444.1  NP_001006444.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCTD6
    Uncharacterized protein
    77(a)
    1 ↔ 1
    GL343510.1(33655-104617)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.81342 Xenopus laevis transcribed sequence with moderate similarity more 74.14(n)    BU901292.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dctd1 dCMP deaminase 74.07(n)
    81.87(a)
      550332  NM_001017639.1  NP_001017639.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69511 , 3 dCMP deaminase3
    CG69511
    51(a)3
    58.18(n)1
    53.42(a)1
      77A43
    402221  NM_168838.21  NP_730502.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK643.26
    Probable deoxycytidylate deaminase
    31(a)
    1 ↔ 1
    III(8956482-8958063)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCD1(YHR144C)4 Deoxycytidine monophosphate (dCMP) deaminase required more   --   8(388726-387788) 856548  NP_012014.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G485401 dCMP deaminase 54.83(n)
    55.03(a)
      824013  NM_114712.2  NP_190423.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g07650001 hypothetical protein 53.41(n)
    53.41(a)
      4326895  NM_001050882.1  NP_001044347.1 


    ENSEMBL Gene Tree for DCTD (if available)
    TreeFam Gene Tree for DCTD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/721 SNPs in DCTD are shown (see all 721)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs723699811,2
    C--179594509(+) TGCCT-/TTTA  
     GAAACCA
    TTTAA
    2 -- int10--------
    rs1392064471,2
    C--183810744(+) CACAAC/TTCTTG 2 -- ds50010--------
    rs1395072561,2
    --183810776(+) TCTCTA/CATTTT 2 -- ds50010--------
    rs68349381,2
    C,F,H--183810813(+) TTCCAC/TATACC 2 -- ds500123Minor allele frequency- T:0.27NS EA WA NA CSA 2761
    rs605072641,2
    F--183810851(+) ACAGGC/TGAGGA 2 -- ds50012Minor allele frequency- T:0.24EA 320
    rs68349681,2
    C,F,A,H--183810852(+) CAGGGC/TGAGGA 2 -- ds500112Minor allele frequency- T:0.38NS EA NA WA CSA 763
    rs1498997251,2
    --183810863(+) GTTTGC/GAGGAG 2 -- ds50010--------
    rs68353181,2
    C,F,A,H--183810865(+) TTGGAG/AGAGAA 2 -- ds500119Minor allele frequency- A:0.40NS EA NA WA CSA 2231
    rs1837347421,2
    --183810973(+) GAGGAC/TAGAGG 2 -- ds50010--------
    rs1449675511,2
    --183811126(+) ACAGCC/TTGGGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DCTD (183811213 - 183839089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DCTD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv881410CNV Loss21882294
    esv24217CNV Loss19812545


    Human Gene Mutation Database (HGMD): DCTD
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607638    OMIM disorders: --

    15 diseases for DCTD:    About MalaCards
    lymphosarcoma    biliary tract cancer    neutropenia    malignant glioma
    acute lymphoblastic leukemia    acute myeloid leukemia    lymphoblastic leukemia    pneumonia
    hepatitis b    pancreatic cancer    myeloid leukemia    leukemia
    pancreatitis    hepatitis    breast cancer


    DCTD for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for DCTD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 28.8 1 1449536 (1)
    tumors 0 5 11697326 (2), 2394614 (1)
    cancer 0 1 1449536 (1)
    immunodeficiency 0 1 12488542 (1)

    Genetic Association Database (GAD): DCTD
    Human Genome Epidemiology (HuGE) Navigator: DCTD (6 documents)

    Export disorders for DCTD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCTD gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with DCTD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. (PubMed id 7685356)1, 2, 9 Weiner K.X.... Maley G.F. (1993)
    2. Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. (PubMed id 7642519)1, 2, 9 Weiner K.X.... Maley G.F. (1995)
    3. Single nucleotide polymorphisms of gemcitabine metabo lic genes and pancreatic cancer survival and drug toxicity. (PubMed id 20028759)1, 4 Okazaki T....Li D. (2010)
    4. Gemcitabine metabolic and transporter gene polymorphi sms are associated with drug toxicity and efficacy in patients with locally adv anced pancreatic cancer. (PubMed id 20665488)1, 4 Tanaka M....Li D. (2010)
    5. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. (PubMed id 17602053)1, 4 Rha S.Y....Chung H.C. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Properties of an affinity-column-purified human deoxycytidylate deaminase. (PubMed id 8448179)1, 9 Maley G.F....Maley F. (1993)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1635 HGNC: 2710 AceView: DCTD Ensembl:ENSG00000129187 euGenes: HUgn1635
    ECgene: DCTD Kegg: 1635 H-InvDB: DCTD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCTD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DCTD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCTD gene:
    Search GeneIP for patents involving DCTD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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