Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DCTD Gene

protein-coding   GIFtS: 65
GCID: GC04M183811

DCMP Deaminase

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
DCMP Deaminase1 2 3
EC 3.5.4.123 8
Deoxycytidylate Deaminase2

External Ids:    HGNC: 27101   Entrez Gene: 16352   Ensembl: ENSG000001291877   OMIM: 6076385   UniProtKB: P323213   

Export aliases for DCTD gene to outside databases

Previous GC identifers: GC04M184830 GC04M184491 GC04M184507 GC04M184186 GC04M184048 GC04M179572


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DCTD Gene:
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for
thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found
as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DCTD Gene:
DCTD (dCMP deaminase) is a protein-coding gene.

UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321
Function: Supplies the nucleotide substrate for thymidylate synthetase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCTD gene promoter:
         HFH-3   NF-1/L   STAT1   AML1a   HTF   STAT1beta   STAT1alpha   FOXI1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCTD promoter sequence
   Search Chromatin IP Primers for DCTD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCTD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

DCTD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTD gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M183811:  view genomic region     (about GC identifiers)

Start:
183,811,213 bp from pter      End:
183,839,089 bp from pter
Size:
27,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321 (See protein sequence)
Recommended Name: Deoxycytidylate deaminase  
Size: 178 amino acids; 20016 Da
Cofactor: Zinc
Subunit: Homohexamer
1 PDB 3D structure from and Proteopedia for DCTD:
2W4L (3D)    
Secondary accessions: B2R836 D3DP49 D3DP50 Q5M7Z8 Q9BVD8
Alternative splicing: 2 isoforms:  P32321-1   P32321-2   

Explore the universe of human proteins at neXtProt for DCTD: NX_P32321

Explore proteomics data for DCTD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for DCTD (P32321)
     QVGACIV  LPWRRTA  LFPCNECAKLIIQ 


    See DCTD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001012750.1  NP_001912.2  

    ENSEMBL proteins: 
     ENSP00000425462   ENSP00000349576   ENSP00000422386   ENSP00000398194   ENSP00000425287  
     ENSP00000424017   ENSP00000422662   ENSP00000424050   ENSP00000423182   ENSP00000423894  
     ENSP00000425904   ENSP00000421792   ENSP00000423498   ENSP00000427470   ENSP00000422729  
     ENSP00000427282  
    Reactome Protein details: P32321

    DCTD Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for DCTD
    OriGene Protein Over-expression Lysate for DCTD
    OriGene MassSpec for DCTD
    OriGene Custom Protein Services for DCTD
    GenScript Custom Purified and Recombinant Proteins Services for DCTD
    Novus Biologicals DCTD Proteins
    Novus Biologicals DCTD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DCTD
    Cloud-Clone Corp. Proteins for DCTD

     
    Search eBioscience for Proteins for DCTD 

     
    antibodies-online proteins for DCTD (18 products) 

     
    antibodies-online peptides for DCTD

    DCTD Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DCTD
    Novus Biologicals DCTD Antibodies
    Abcam antibodies for DCTD
    Cloud-Clone Corp. Antibodies for DCTD
    ThermoFisher Antibodies for DCTD
    antibodies-online antibodies for DCTD (30 products) 

    DCTD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DCTD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DCTD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DCTD
    Cloud-Clone Corp. CLIAs for DCTD
    Search eBioscience for ELISAs for DCTD 
    antibodies-online kits for DCTD (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR002125 CMP_dCMP_Zn-bd
     IPR016473 dCMP_deaminase
     IPR016193 Cytidine_deaminase-like
     IPR015517 Cyt_deaminase

    Graphical View of Domain Structure for InterPro Entry P32321

    ProtoNet protein and cluster: P32321

    1 Blocks protein domain: IPB002125 Cytidine/deoxycytidylate deaminase

    UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family


    Find genes that share domains with DCTD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCTD_HUMAN, P32321
    Function: Supplies the nucleotide substrate for thymidylate synthetase
    Catalytic activity: dCMP + H(2)O = dUMP + NH(3)
    Enzyme regulation: Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic
    pathway, dCTP and dTTP

         Enzyme Number (IUBMB): EC 3.5.4.121 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004132dCMP deaminase activity EXP--
    GO:0008270zinc ion binding IEA--
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
         
    Find genes that share ontologies with DCTD           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DCTD:
     Increased cell death HMECs cel 

         1 MGI phenotypic allele for Dctd (no phenotypes)

    Find genes that share phenotypes with DCTD           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DCTD

    miRNA
    Products:
        
    miRTarBase miRNAs that target DCTD:
    hsa-mir-101-3p (MIRT027308), hsa-mir-26b-5p (MIRT030192), hsa-mir-1301-3p (MIRT036043), hsa-mir-1229-3p (MIRT036295), hsa-mir-124-3p (MIRT002623), hsa-mir-92a-3p (MIRT049262), hsa-let-7b-5p (MIRT051915), hsa-mir-7-5p (MIRT025957)

    Block miRNA regulation of human, mouse, rat DCTD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCTD (see all 16):
    hsa-miR-411* hsa-miR-485-5p hsa-miR-3910 hsa-miR-3607-5p hsa-miR-379* hsa-miR-944 hsa-miR-488 hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidDCTD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DCTD
    Predesigned siRNA for gene silencing in human, mouse, rat DCTD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DCTD

    Clone
    Products:
         
    OriGene clones in human, mouse for DCTD (see all 12)
    OriGene ORF clones in mouse, rat for DCTD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DCTD (NM_001921)
    Sino Biological Human cDNA Clone for DCTD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCTD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTD

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DCTD
    Browse ESI BIO Cell Lines and PureStem Progenitors for DCTD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular2
    endoplasmic reticulum1
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with DCTD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DCTD About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    2Pyrimidine metabolism
    Pyrimidine metabolism0.33
    Pyrimidine biosynthesis0.00
    3Purine metabolism (REACTOME)
    Metabolism of nucleotides0.42
    4Purine metabolism (KEGG)
    Pyrimidine metabolism0.38
    5superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    pyrimidine deoxyribonucleotides biosynthesis from CTP0.00


    Find genes that share SuperPaths with DCTD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DCTD
        pyrimidine deoxyribonucleotides biosynthesis from CTP


    1 Reactome Pathway for DCTD
        Pyrimidine biosynthesis


    2 Kegg Pathways  (Kegg details for DCTD):
        Pyrimidine metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCTD
    Interactions:

        Search GeneGlobe Interaction Network for DCTD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCTD (P323212, 3 ENSP000003495764) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP76Q8TAP62, 3, ENSP000002621274MINT-66933 I2D: score=5 STRING: ENSP00000262127
    LNX1Q8TBB12, 3, ENSP000002639254MINT-66043 I2D: score=5 STRING: ENSP00000263925
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-68250 I2D: score=5 STRING: ENSP00000386394
    NUDT18Q6ZVK82, 3, ENSP000003078524MINT-67667 I2D: score=5 STRING: ENSP00000307852
    ZNF764Q96H863I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006220pyrimidine nucleotide metabolic process TAS7685356
    GO:0009165nucleotide biosynthetic process IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0046134pyrimidine nucleoside biosynthetic process TAS--

    Find genes that share ontologies with DCTD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCTD

    4 HMDB Compounds for DCTD    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    dCMP2'-Deoxycytidine 5'-monophosphate (see all 12)1032-65-1--
    dUMP2'-Deoxy-5'-uridylate (see all 12)964-26-1--

    Selected Novoseek inferred chemical compound relationships for DCTD gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dcmp 96.4 49 12488542 (5), 12771412 (3), 7685356 (3), 8448179 (3) (see all 25)
    tetrahydrouridine 92.6 1 11697326 (1)
    deoxycytidine 88.9 9 11697326 (1), 12019082 (1), 8226747 (1), 19531250 (1) (see all 8)
    ara-ctp 87.5 3 1780754 (1), 19842938 (1), 9680112 (1)
    dctp 87 7 12488542 (1), 9988115 (1), 18255096 (1), 8448179 (1) (see all 6)
    dttp 85.5 7 8448179 (1), 2232889 (1), 8117667 (1), 15520873 (1)
    cytidine 82.9 11 10497201 (1), 16551864 (1), 19531250 (1), 18255096 (1) (see all 9)
    dichloromethane 82.1 24 12488542 (2), 7642519 (2), 1449536 (2), 8448179 (2) (see all 18)
    zebularine 79 2 12771412 (1), 8583252 (1)
    thymidylate 75.5 5 8798492 (1), 17416930 (1), 15992031 (1), 2247612 (1) (see all 5)



    Find genes that share compounds with DCTD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DCTD gene (2 alternative transcripts): 
    NM_001012732.1  NM_001921.2  

    Unigene Cluster for DCTD:

    DCMP deaminase
    Hs.183850  [show with all ESTs]
    Unigene Representative Sequence: NM_001012732
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500813(uc010irw.3 uc003ivh.3) ENST00000357067(uc003ivf.3 uc003ivg.3)
    ENST00000507543 ENST00000438320 ENST00000507631 ENST00000510370 ENST00000503182
    ENST00000510307 ENST00000512766 ENST00000514754 ENST00000513383 ENST00000513348
    ENST00000503820 ENST00000509757 ENST00000509218 ENST00000503988 ENST00000508994

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DCTD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCTD (see all 16):
    hsa-miR-411* hsa-miR-485-5p hsa-miR-3910 hsa-miR-3607-5p hsa-miR-379* hsa-miR-944 hsa-miR-488 hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmidDCTD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DCTD
    Predesigned siRNA for gene silencing in human, mouse, rat DCTD
    Clone
    Products:
         
    OriGene clones in human, mouse for DCTD (see all 12)
    OriGene ORF clones in mouse, rat for DCTD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DCTD (NM_001921)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCTD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DCTD
    OriGene qSTAR qPCR primer pairs in human, mouse for DCTD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCTD
      QuantiTect SYBR Green Assays in human, mouse, rat DCTD
      QuantiFast Probe-based Assays in human, mouse, rat DCTD

    Additional mRNA sequence: 

    AK293135.1 AK310788.1 AK313221.1 BC001286.1 BC088357.1 L12136.1 

    22 DOTS entries:

    DT.447710  DT.97852127  DT.92445882  DT.100823701  DT.100823692  DT.100823699  DT.92445880  DT.100009520 
    DT.92445881  DT.100823694  DT.100823695  DT.121226583  DT.97852126  DT.100823690  DT.95154826  DT.100029197 
    DT.100823693  DT.91846060  DT.92445890  DT.95154840  DT.121226595  DT.92015862 

    Selected AceView cDNA sequences (see all 381):

    AW301176 BM930047 BU625771 AI362775 CD674497 BQ576054 BM309913 CA423655 
    BQ946562 AU121520 AA284491 BI438577 AA593593 BQ007899 BU188090 BP378968 
    BU625871 BU615634 BI333229 BG167851 BU728657 CA421632 CB112799 BM700396 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCTD (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^
    SP1:        -     -     -     -     -     -     -     -     -     -     -     -                                                                                 
    SP2:                                -     -     -     -     -     -     -     -                                                                                 
    SP3:                                      -     -     -     -     -     -     -                                                                                 
    SP4:                                                                          -                                                                                 
    SP5:                                -     -     -     -     -     -     -     -           -     -                                                               

    ExUns: 11 ^ 12
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for DCTD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DCTD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTTTATT
    DCTD Expression
    About this image


    DCTD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Midgut
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Uterus (Reproductive System)
    DCTD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCTD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.183850
        Custom PCR Arrays for DCTD
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DCTD
    OriGene qSTAR qPCR primer pairs in human, mouse for DCTD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCTD
    QuantiTect SYBR Green Assays in human, mouse, rat DCTD
    QuantiFast Probe-based Assays in human, mouse, rat DCTD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCTD gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dctd1 , 5 dCMP deaminase1, 5 86.67(n)1
    92.78(a)1
      8 (26.98 cM)5
    3206851  NM_001161515.11  NP_001154987.11 
     480990925 
    chicken
    (Gallus gallus)
    Aves DCTD1 dCMP deaminase 78.41(n)
    86.36(a)
      422556  NM_001006444.1  NP_001006444.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCTD6
    dCMP deaminase
    76(a)
    1 ↔ 1
    GL343510.1(33655-104617)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.81342 Xenopus laevis transcribed sequence with moderate similarity more 74.14(n)    BU901292.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dctd1 dCMP deaminase 74.07(n)
    81.87(a)
      550332  NM_001017639.1  NP_001017639.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG69511 , 3 dCMP deaminase3
    CG69511
    51(a)3
    58.23(n)1
    53.09(a)1
      77A43
    402221  NM_140940.31  NP_649197.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK643.26
    Protein ZK643.2 (ZK643.2) mRNA, complete cds
    31(a)
    1 ↔ 1
    III(8956482-8958063) WBGene00014034
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCD1(YHR144C)4 Deoxycytidine monophosphate (dCMP) deaminase required more   --   8(388726-387788) 856548  NP_012014.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G485401 AT3G48540 54.83(n)
    55.03(a)
      824013  NM_114712.2  NP_190423.2 
    rice
    (Oryza sativa)
    Liliopsida Os01g07650001 Os01g0765000 53.41(n)
    53.41(a)
      4326895  NM_001050882.1  NP_001044347.1 


    ENSEMBL Gene Tree for DCTD (if available)
    TreeFam Gene Tree for DCTD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DCTD (see all 721)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs723699811,2
    C--179594509(+) TGCCT-/TTTA  
     GAAACCA
    TTTAA
    2 -- int10--------
    rs1392064471,2
    C--183810744(+) CACAAC/TTCTTG 2 -- ds50010--------
    rs1395072561,2
    --183810776(+) TCTCTA/CATTTT 2 -- ds50010--------
    rs68349381,2
    C,F,H--183810813(+) TTCCAC/TATACC 2 -- ds500123Minor allele frequency- T:0.27NS EA WA NA CSA 2761
    rs605072641,2
    F--183810851(+) ACAGGC/TGAGGA 2 -- ds50012Minor allele frequency- T:0.24EA 320
    rs68349681,2
    C,F,A,H--183810852(+) CAGGGC/TGAGGA 2 -- ds500112Minor allele frequency- T:0.38NS EA NA WA CSA 763
    rs1498997251,2
    --183810863(+) GTTTGC/GAGGAG 2 -- ds50010--------
    rs68353181,2
    C,F,A,H--183810865(+) TTGGAG/AGAGAA 2 -- ds500119Minor allele frequency- A:0.40NS EA NA WA CSA 2231
    rs1837347421,2
    --183810973(+) GAGGAC/TAGAGG 2 -- ds50010--------
    rs1449675511,2
    --183811126(+) ACAGCC/TTGGGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DCTD (183811213 - 183839089 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DCTD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv881410CNV Loss21882294
    esv24217CNV Loss19812545

    Human Gene Mutation Database (HGMD): DCTD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCTD
    DNA2.0 Custom Variant and Variant Library Synthesis for DCTD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607638    OMIM disorders: --


    Find genes that share disorders with DCTD           About GenesLikeMe

    4 Novoseek inferred disease relationships for DCTD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 28.8 1 1449536 (1)
    tumors 0 5 11697326 (2), 2394614 (1)
    cancer 0 1 1449536 (1)
    immunodeficiency 0 1 12488542 (1)

    Genetic Association Database (GAD): DCTD
    Human Genome Epidemiology (HuGE) Navigator: DCTD (6 documents)

    Export disorders for DCTD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DCTD gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with DCTD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. (PubMed id 7685356)1, 2, 9 Weiner K.X.... Maley G.F. (J. Biol. Chem. 1993)
    2. Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. (PubMed id 7642519)1, 2, 9 Weiner K.X.... Maley G.F. (J. Biol. Chem. 1995)
    3. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PubMed id 20028759)1, 4 Okazaki T....Li D. (Clin. Cancer Res. 2010)
    4. Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. (PubMed id 20665488)1, 4 Tanaka M....Li D. (Cancer 2010)
    5. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. (PubMed id 17602053)1, 4 Rha S.Y....Chung H.C. (Oncologist 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Properties of an affinity-column-purified human deoxycytidylate deaminase. (PubMed id 8448179)1, 9 Maley G.F....Maley F. (Biochim. Biophys. Acta 1993)
    8. Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis. (PubMed id 23740775)1 Xie G....Siminovitch K.A. (Arthritis Rheum. 2013)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1635 HGNC: 2710 AceView: DCTD Ensembl:ENSG00000129187 euGenes: HUgn1635
    ECgene: DCTD Kegg: 1635 H-InvDB: DCTD

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DCTD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DCTD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DCTD gene:
    Search GeneIP for patents involving DCTD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DCTD  
     OriGene qPCR primer pairs and template standards for DCTD   OriGene Protein Over-expression Lysate for DCTD  
     OriGene MassSpec for DCTD   OriGene clones in human, mouse for DCTD  
     OriGene qSTAR qPCR primer pairs in human, mouse for DCTD   OriGene Purified Protein for DCTD  
     OriGene ORF clones in mouse, rat for DCTD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DCTD   OriGene Custom Protein Services for DCTD  

     
     
     Block miRNA regulation of human, mouse, rat DCTD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DCTD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCTD Predesigned siRNA for gene silencing in human, mouse, rat DCTD
     QuantiFast Probe-based Assays in human, mouse, rat DCTD QuantiTect SYBR Green Assays in human, mouse, rat DCTD
     Custom PCR Arrays for DCTD Search Chromatin IP Primers for DCTD
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCTD  Search GeneGlobe Interaction Network for DCTD
     Regulatory tfbs in DCTD promoter
     GenScript Custom Purified and Recombinant Proteins Services for DCTD GenScript cDNA clones with any tag delivered in your preferred vector for DCTD
     GenScript Custom Assay Services for DCTD GenScript Custom overexpressing Cell Line Services for DCTD
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DCTD
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DCTD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DCTD antibodies
     DCTD proteins
     DCTD lysates
     Antibodies for DCTD
     See all of Abcam's Antibodies, Kits and Proteins for DCTD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DCTD
     Proteins for DCTD
     Antibodies for DCTD
     ELISAs for DCTD
     CLIAs for DCTD



     Browse ESI BIO Cell Lines and PureStem Progenitors for DCTD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTD
     SwitchGear 3'UTR luciferase reporter plasmids for DCTD
     SwitchGear Promoter luciferase reporter plasmids for DCTD
     ThermoFisher Antibodies for DCTD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTD
     Browse compounds at ApexBio
     Search Addgene for plasmids for DCTD
      Search eBioscience for proteins for DCTD
      Search eBioscience for elisas for DCTD
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DCTD
     antibodies-online antibodies for DCTD (30 products)
     antibodies-online kits for DCTD (6 products)
     antibodies-online peptides for DCTD
     antibodies-online proteins for DCTD (18 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DCTD gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4