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Aliases for DCTD Gene

Aliases for DCTD Gene

  • DCMP Deaminase 2 3 4
  • EC 3.5.4.12 4 63

External Ids for DCTD Gene

Previous GeneCards Identifiers for DCTD Gene

  • GC04M184830
  • GC04M184491
  • GC04M184507
  • GC04M184186
  • GC04M184048
  • GC04M183811
  • GC04M179572

Summaries for DCTD Gene

Entrez Gene Summary for DCTD Gene

  • The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCTD Gene

DCTD (DCMP Deaminase) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism. GO annotations related to this gene include hydrolase activity and dCMP deaminase activity.

UniProtKB/Swiss-Prot for DCTD Gene

  • Supplies the nucleotide substrate for thymidylate synthetase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTD Gene

Genomics for DCTD Gene

Regulatory Elements for DCTD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCTD Gene

Chromosome:
4
Start:
182,890,060 bp from pter
End:
182,917,936 bp from pter
Size:
27,877 bases
Orientation:
Minus strand

Genomic View for DCTD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCTD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTD Gene

Proteins for DCTD Gene

  • Protein details for DCTD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32321-DCTD_HUMAN
    Recommended name:
    Deoxycytidylate deaminase
    Protein Accession:
    P32321
    Secondary Accessions:
    • B2R836
    • D3DP49
    • D3DP50
    • Q5M7Z8
    • Q9BVD8

    Protein attributes for DCTD Gene

    Size:
    178 amino acids
    Molecular mass:
    20016 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for DCTD Gene

    Alternative splice isoforms for DCTD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTD Gene

Proteomics data for DCTD Gene at MOPED

Selected DME Specific Peptides for DCTD Gene

Post-translational modifications for DCTD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for DCTD Gene

Suggested Antigen Peptide Sequences for DCTD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P32321

UniProtKB/Swiss-Prot:

DCTD_HUMAN :
  • Contains 1 CMP/dCMP-type deaminase domain.
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with DCTD: view

No data available for Gene Families for DCTD Gene

Function for DCTD Gene

Molecular function for DCTD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
dCMP + H(2)O = dUMP + NH(3)
UniProtKB/Swiss-Prot EnzymeRegulation:
Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP
UniProtKB/Swiss-Prot Function:
Supplies the nucleotide substrate for thymidylate synthetase

Enzyme Numbers (IUBMB) for DCTD Gene

Gene Ontology (GO) - Molecular Function for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004132 dCMP deaminase activity EXP --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with DCTD: view

Phenotypes for DCTD Gene

genes like me logo Genes that share phenotypes with DCTD: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTD

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DCTD Gene

Localization for DCTD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCTD Gene COMPARTMENTS Subcellular localization image for DCTD gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with DCTD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCTD Gene

Pathways & Interactions for DCTD Gene

genes like me logo Genes that share pathways with DCTD: view

Pathways by source for DCTD Gene

Gene Ontology (GO) - Biological Process for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0006220 pyrimidine nucleotide metabolic process IEA --
GO:0008152 metabolic process --
GO:0009165 nucleotide biosynthetic process IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with DCTD: view

No data available for SIGNOR curated interactions for DCTD Gene

Drugs & Compounds for DCTD Gene

(11) Drugs for DCTD Gene - From: HMDB, NovoSeek, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma Enzyme, substrate 995
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1800
dCMP Experimental Pharma 0
dUMP Experimental Pharma 0
Cytidine Experimental Pharma 0

(11) Additional Compounds for DCTD Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
2-Chlorodeoxyadenosine
Ara-CTP
ctp
genes like me logo Genes that share compounds with DCTD: view

Transcripts for DCTD Gene

Unigene Clusters for DCTD Gene

DCMP deaminase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCTD

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTD Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - - - -
SP9: - - -
SP10: - - -
SP11:
SP12:
SP13:

ExUns: 11 ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for DCTD Gene

GeneLoc Exon Structure for
DCTD
ECgene alternative splicing isoforms for
DCTD

Expression for DCTD Gene

mRNA expression in normal human tissues for DCTD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCTD Gene



SOURCE GeneReport for Unigene cluster for DCTD Gene Hs.183850

genes like me logo Genes that share expression patterns with DCTD: view

Protein tissue co-expression partners for DCTD Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTD Gene

Orthologs for DCTD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCTD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCTD 35
  • 87.64 (n)
  • 92.7 (a)
DCTD 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC607328 35
  • 88.26 (n)
  • 90.57 (a)
DCTD 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dctd 35
  • 86.67 (n)
  • 92.78 (a)
Dctd 16
Dctd 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCTD 35
  • 97 (n)
  • 96.3 (a)
DCTD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctd 35
  • 86.11 (n)
  • 92.78 (a)
oppossum
(Monodelphis domestica)
Mammalia DCTD 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCTD 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCTD 35
  • 78.41 (n)
  • 86.36 (a)
DCTD 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCTD 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctd 35
  • 76.86 (n)
  • 84.12 (a)
Str.8923 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8134 35
zebrafish
(Danio rerio)
Actinopterygii dctd 35
  • 74.07 (n)
  • 81.87 (a)
dctd 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6951 37
  • 51 (a)
CG6951 35
  • 58.23 (n)
  • 53.09 (a)
CG6951 36
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008158 35
  • 63.73 (n)
  • 63.52 (a)
worm
(Caenorhabditis elegans)
Secernentea ZK643.2 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCD1 36
  • 14 (a)
OneToOne
DCD1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G48540 35
  • 54.83 (n)
  • 55.03 (a)
rice
(Oryza sativa)
Liliopsida Os01g0765000 35
  • 53.41 (n)
  • 53.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 65 (a)
OneToOne
Species with no ortholog for DCTD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTD Gene

ENSEMBL:
Gene Tree for DCTD (if available)
TreeFam:
Gene Tree for DCTD (if available)

Paralogs for DCTD Gene

No data available for Paralogs for DCTD Gene

Variants for DCTD Gene

Structural Variations from Database of Genomic Variants (DGV) for DCTD Gene

Variant ID Type Subtype PubMed ID
nsv881410 CNV Loss 21882294
esv24217 CNV Loss 19812545

Variation tolerance for DCTD Gene

Residual Variation Intolerance Score: 29.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCTD Gene

HapMap Linkage Disequilibrium report
DCTD
Human Gene Mutation Database (HGMD)
DCTD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DCTD Gene

Disorders for DCTD Gene

Relevant External Links for DCTD

Genetic Association Database (GAD)
DCTD
Human Genome Epidemiology (HuGE) Navigator
DCTD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCTD
genes like me logo Genes that share disorders with DCTD: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTD Gene

Publications for DCTD Gene

  1. Genetic factors influencing cytarabine therapy. (PMID: 19842938) Lamba J.K. (Pharmacogenomics 2009) 23 25 26 67
  2. Gemcitabine sensitivity-related mRNA expression in endoscopic ultrasound-guided fine-needle aspiration biopsy of unresectable pancreatic cancer. (PMID: 19531250) Ashida R. … Yamao K. (J. Exp. Clin. Cancer Res. 2009) 23 67
  3. Crystal structures of Streptococcus mutans 2'-deoxycytidylate deaminase and its complex with substrate analog and allosteric regulator dCTP x Mg2+. (PMID: 18255096) Hou H.F. … Dong Y.H. (J. Mol. Biol. 2008) 23 67
  4. Intracellular metabolism of the new antiviral compound 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine. (PMID: 18773877) Naesens L. … Snoeck R. (Biochem. Pharmacol. 2008) 23 67
  5. p53R2-dependent ribonucleotide reduction provides deoxyribonucleotides in quiescent human fibroblasts in the absence of induced DNA damage. (PMID: 17416930) Pontarin G. … Bianchi V. (J. Biol. Chem. 2007) 23 67

Products for DCTD Gene

Sources for DCTD Gene

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