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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCTD Gene

protein-coding   GIFtS: 64
GCID: GC04M183811

dCMP deaminase
 Explore 16 diseases affiliated with
DCTD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DCTD    

Aliases
for DCTD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DCMP Deaminase1 2 3
EC 3.5.4.123 8
Deoxycytidylate Deaminase2

External Ids:    HGNC: 27101   Entrez Gene: 16352   Ensembl: ENSG000001291877   OMIM: 6076385   UniProtKB: P323213   

Export aliases for DCTD gene to outside databases

Previous GC identifers: GC04M184830 GC04M184491 GC04M184507 GC04M184186 GC04M184048 GC04M179572


Summaries
for DCTD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DCTD:
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate
synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a
homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321
Function: Supplies the nucleotide substrate for thymidylate synthetase




Genomic Views
for DCTD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCTD gene promoter:
         HFH-3   NF-1/L   STAT1   AML1a   HTF   STAT1beta   STAT1alpha   FOXI1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DCTD promoter sequence
   Search SABiosciences Chromatin IP Primers for DCTD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCTD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.1   Ensembl cytogenetic band:  4q35.1   HGNC cytogenetic band: 4q35.1

DCTD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCTD gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M183811:  view genomic region     (about GC identifiers)

Start:
 183,811,213 bp from pter      End:
 183,839,089 bp from pter
Size:
 27,877 bases      Orientation:
 minus strand

Proteins
for DCTD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321 (See protein sequence)
Recommended Name: Deoxycytidylate deaminase  
Size: 178 amino acids; 20016 Da
Cofactor: Zinc
Subunit: Homohexamer
1 PDB 3D structure from and Proteopedia for DCTD:
2W4L (3D)    
Secondary accessions: B2R836 D3DP49 D3DP50 Q5M7Z8 Q9BVD8
Alternative splicing: 2 isoforms:  P32321-1   P32321-2   

Explore the universe of human proteins at neXtProt for DCTD: NX_P32321

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P32321

    • 3 DME Specific Peptides for DCTD (P32321)
     QVGACIV  LPWRRTA  LFPCNECAKLIIQ 

    DCTD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001012750.1  NP_001912.2  

    ENSEMBL proteins: 
     ENSP00000425462   ENSP00000349576   ENSP00000422386   ENSP00000398194   ENSP00000425287  
     ENSP00000424017   ENSP00000422662   ENSP00000424050   ENSP00000423182   ENSP00000423894  
     ENSP00000425904   ENSP00000421792   ENSP00000423498   ENSP00000427470   ENSP00000422729  
     ENSP00000427282  
    Reactome Protein details: P32321
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): DCTD
    OriGene Protein Over-expression Lysate (see all 3): DCTD
    OriGene Custom Protein Services for DCTD 
    GenScript Custom Purified and Recombinant Proteins Services for DCTD
    Novus Biologicals DCTD Proteins
    Novus Biologicals DCTD Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for DCTD
    Uscn Proteins for DCTD

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--


    DCTD for ontologies           About GeneDecksing



    DCTD Antibody Products: 
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    Uscn ELISAs and CLIAs for DCTD

    Protein Domains /
    Families
    for DCTD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DCTD for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016192 APOBEC/CMP_deaminase_Zn-bd
     IPR002125 CMP_dCMP_Zn-bd
     IPR016473 dCMP_deaminase
     IPR016193 Cytidine_deaminase-like
     IPR015517 Cyt_deaminase

    Graphical View of Domain Structure for InterPro Entry P32321

    ProtoNet protein and cluster: P32321

    1 Blocks protein family: IPB002125 Cytidine/deoxycytidylate deaminase

    UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family


    Function
    for DCTD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DCTD_HUMAN, P32321
    Function: Supplies the nucleotide substrate for thymidylate synthetase
    Catalytic activity: dCMP + H(2)O = dUMP + NH(3)
    Enzyme regulation: Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway,
    dCTP and dTTP

    Enzyme Number (IUBMB): EC 3.5.4.121 2

    miRNA
    Products:            		miRTarBase miRNAs that target DCTD:
    hsa-mir-124 (MIRT002623)

    OriGene 3'-UTR Clone (see all 2): DCTD
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCTD
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate DCTD (see all 16):
    hsa-miR-411* hsa-miR-485-5p hsa-miR-3910 hsa-miR-3607-5p hsa-miR-379* hsa-miR-944 hsa-miR-488 hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmid: DCTD 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCTD (see all 7)
    OriGene shRNA RFP: DCTD
    OriGene siRNA: DCTD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCTD

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DCTD

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCTD (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): DCTD (NM_001921)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCTD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCTD 

    Cell Line
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    Search LifeMap BioReagents cell lines for DCTD

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTD

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004132dCMP deaminase activity EXP--
    GO:0008270zinc ion binding IEA--
    GO:0016787hydrolase activity ----
    GO:0016810hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----


    DCTD for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DCTD:
     Increased cell death HMECs cel 

    Animal Models:
         1 MGI phenotypic allele for Dctd (no phenotypes)

    DCTD for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DCTD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    2Pyrimidine metabolism
    		Pyrimidine metabolism1.00
    3Pyrimidine biosynthesis
    		Pyrimidine biosynthesis1.00
    4Purine metabolism
    		Metabolism of nucleotides0.42
    5Purine metabolism
    		Pyrimidine metabolism0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for DCTD
        Metabolism of nucleotides
    Metabolism
    Pyrimidine metabolism
    Pyrimidine biosynthesis


    2         Kegg Pathways  (Kegg details for DCTD):
        Pyrimidine metabolism
    Metabolic pathways


    DCTD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCTD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/24 Interacting proteins for DCTD (P323212, 3 ENSP000003495764) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP76Q8TAP62, 3, ENSP000002621274MINT-66933 I2D: score=5 STRING: ENSP00000262127
    LNX1Q8TBB12, 3, ENSP000002639254MINT-66043 I2D: score=5 STRING: ENSP00000263925
    NIF3L1Q9GZT82, 3, ENSP000003863944MINT-68250 I2D: score=5 STRING: ENSP00000386394
    NUDT18Q6ZVK82, 3, ENSP000003078524MINT-67667 I2D: score=5 STRING: ENSP00000307852
    ZNF764Q96H863I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006220pyrimidine nucleotide metabolic process TAS7685356
    GO:0009165nucleotide biosynthetic process IEA--
    GO:0044281small molecule metabolic process TAS--
    GO:0046134pyrimidine nucleoside biosynthetic process TAS--


    DCTD for ontologies           About GeneDecksing



    Drugs & Compounds
    for DCTD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DCTD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCTD

    4 HMDB Compounds for DCTD    About this table
    CompoundSynonyms CAS #PubMed Ids
    AmmoniaNH3 (see all 31)7664-41-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--
    dCMP2'-Deoxycytidine 5'-monophosphate (see all 12)1032-65-1--
    dUMP2'-Deoxy-5'-uridylate (see all 12)964-26-1--
    10/18 Novoseek chemical compound relationships for DCTD gene (see all 18)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dcmp 96.4 49 12488542 (5), 12771412 (3), 7685356 (3), 8448179 (3) (see all 25)
    tetrahydrouridine 92.6 1 11697326 (1)
    deoxycytidine 88.9 9 11697326 (1), 12019082 (1), 8226747 (1), 19531250 (1) (see all 8)
    ara-ctp 87.5 3 1780754 (1), 19842938 (1), 9680112 (1)
    dctp 87 7 12488542 (1), 9988115 (1), 18255096 (1), 8448179 (1) (see all 6)
    dttp 85.5 7 8448179 (1), 2232889 (1), 8117667 (1), 15520873 (1)
    cytidine 82.9 11 10497201 (1), 16551864 (1), 19531250 (1), 18255096 (1) (see all 9)
    dichloromethane 82.1 24 12488542 (2), 7642519 (2), 1449536 (2), 8448179 (2) (see all 18)
    zebularine 79 2 12771412 (1), 8583252 (1)
    thymidylate 75.5 5 8798492 (1), 17416930 (1), 15992031 (1), 2247612 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about DCTD 

    Transcripts
    for DCTD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DCTD gene (2 alternative transcripts): 
    NM_001012732.1  NM_001921.2  

    Unigene Cluster for DCTD:

    DCMP deaminase
    Hs.183850  [show with all ESTs]
    Unigene Representative Sequence: NM_001012732
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500813(uc010irw.3 uc003ivh.3) ENST00000357067(uc003ivf.3 uc003ivg.3)
    ENST00000507543 ENST00000438320 ENST00000507631 ENST00000510370 ENST00000503182
    ENST00000510307 ENST00000512766 ENST00000514754 ENST00000513383 ENST00000513348
    ENST00000503820 ENST00000509757 ENST00000509218 ENST00000503988 ENST00000508994


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): DCTD
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCTD
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate DCTD (see all 16):
    hsa-miR-411* hsa-miR-485-5p hsa-miR-3910 hsa-miR-3607-5p hsa-miR-379* hsa-miR-944 hsa-miR-488 hsa-miR-1304
    SwitchGear 3'UTR luciferase reporter plasmid: DCTD 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCTD (see all 7)
    OriGene shRNA RFP: DCTD
    OriGene siRNA: DCTD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCTD
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK293135.1 AK310788.1 AK313221.1 BC001286.1 BC088357.1 L12136.1 

    22 DOTS entries:

    DT.447710  DT.97852127  DT.92445882  DT.100823701  DT.100823692  DT.100823699  DT.92445880  DT.100009520 
    DT.92445881  DT.100823694  DT.100823695  DT.121226583  DT.97852126  DT.100823690  DT.95154826  DT.100823693 
    DT.91846060  DT.92445890  DT.95154840  DT.100029197  DT.121226595  DT.92015862 

    24/381 AceView cDNA sequences (see all 381):

    BM759471 T55740 BM700396 BI438577 H30279 BI835533 CR591914 BG656447 
    CR604027 CA421632 AA313864 CD674497 BM930047 CB112799 CR615419 AU121520 
    BU625871 BQ946562 BG167851 BP353941 BU625771 CA431426 BU728657 AA284491 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for DCTD (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^
    SP1:        -     -     -     -     -     -     -     -     -     -     -     -                                                                                 
    SP2:                                -     -     -     -     -     -     -     -                                                                                 
    SP3:                                      -     -     -     -     -     -     -                                                                                 
    SP4:                                                                          -                                                                                 
    SP5:                                -     -     -     -     -     -     -     -           -     -                                                               

    ExUns: 11 ^ 12
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for DCTD

    Expression
    for DCTD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCTD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTTTTTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DCTD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DCTD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCTD

    SOURCE GeneReport for Unigene cluster: Hs.183850
        SABiosciences Custom PCR Arrays for DCTD
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCTD
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCTD
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCTD

    Orthologs
    for DCTD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCTD gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dctd1 , 5 dCMP deaminase1, 5 86.67(n)1
    92.78(a)1    		   8 (26.98 cM)5
    3206851  NM_001161515.11  NP_001154987.11 
     480990925 
    chicken
    (Gallus gallus)    		 Aves DCTD1 dCMP deaminase 78.41(n)
    86.36(a)    		   422556  NM_001006444.1  NP_001006444.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DCTD6
    		 --
    		 87(a)
    		 1 ↔ 1
    		 GL343510.1(44727-57983)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.81342 Xenopus laevis transcribed sequence with moderate similarity more 74.14(n)    BU901292.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dctd1 dCMP deaminase 74.07(n)
    81.87(a)    		   550332  NM_001017639.1  NP_001017639.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG69511 , 3 dCMP deaminase3
    CG69511    		 51(a)3
    58.18(n)1
    53.42(a)1    		   77A43
    402221  NM_168838.21  NP_730502.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ZK643.26
    		 Probable deoxycytidylate deaminase
    		 31(a)
    		 1 ↔ 1
    		 III(8956405-8957986)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT3G485401 dCMP deaminase 54.83(n)
    55.03(a)    		   824013  NM_114712.2  NP_190423.2 
    rice
    (Oryza sativa)    		 Liliopsida Os01g07650001 hypothetical protein 53.41(n)
    53.41(a)    		   4326895  NM_001050882.1  NP_001044347.1 


    ENSEMBL Gene Tree for DCTD (if available)
    TreeFam Gene Tree for DCTD (if available) 

    Paralogs
    for DCTD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DCTD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DCTD
         1 Indel: 68859
    Human Gene Mutation Database (HGMD): DCTD
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCTD
    DNA2.0 Custom Variant and Variant Library Synthesis for DCTD

    Disorders / Diseases
    for DCTD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DCTD for disorders           About GeneDecksing

    OMIM gene information: 607638    OMIM disorders: --

    16 diseases for DCTD:    About MalaCards
    biliary tract cancer    lymphosarcoma    acute lymphoblastic leukemia    lymphoblastic leukemia
    acute myeloid leukemia    myeloid leukemia    malignant glioma    neutropenia
    leukemia    hepatitis b    immunodeficiency    pancreatic cancer
    breast cancer    pancreatitis    hepatitis    pneumonia

    4 Novoseek disease relationships for DCTD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 28.8 1 1449536 (1)
    tumors 0 5 11697326 (2), 2394614 (1)
    cancer 0 1 1449536 (1)
    immunodeficiency 0 1 12488542 (1)

    Human Genome Epidemiology (HuGE) Navigator: DCTD (6 documents)

    Export disorders for DCTD gene to outside databases

    Publications
    for DCTD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCTD gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with DCTD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. (PubMed id 7685356)1, 2, 9 Weiner K.X.... Maley G.F. (1993)
    2. Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. (PubMed id 7642519)1, 2, 9 Weiner K.X.... Maley G.F. (1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Properties of an affinity-column-purified human deoxycytidylate deaminase. (PubMed id 8448179)1, 9 Maley G.F....Maley F. (1993)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Single nucleotide polymorphisms of gemcitabine metabo lic genes and pancreatic cancer survival and drug toxicity. (PubMed id 20028759)1 Okazaki T....Li D. (2010)
    8. Gemcitabine metabolic and transporter gene polymorphi sms are associated with drug toxicity and efficacy in patients with locally adv anced pancreatic cancer. (PubMed id 20665488)1 Tanaka M....Li D. (2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. (PubMed id 17602053)1 Rha S.Y....Chung H.C. (2007)

    External Searches for DCTD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DCTD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1635 HGNC: 2710 AceView: DCTD Ensembl:ENSG00000129187 euGenes: HUgn1635
    ECgene: DCTD Kegg: 1635 H-InvDB: DCTD

    Other Databases showing DCTD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DCTD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCTD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DCTD Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DCTD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DCTD gene:
    Search GeneIP for patents involving DCTD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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