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DCT Gene

protein-coding   GIFtS: 60
GCID: GC13M095091

Dopachrome Tautomerase

(Previous name: tyrosine-related protein 2)
(Previous symbol: TYRP2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dopachrome Tautomerase1 2     TRP-22 3
TYRP21 2 3 5     TRP22 3
Tyrosine-Related Protein 21 2     L-Dopachrome Delta-Isomerase2 3
Dopachrome Delta-Isomerase1 2     EC 5.3.3.123 8
Tyrosinase-Related Protein 22 3     Dopachrome Tautomerase (Dopachrome Delta-Isomerase, Tyrosine-Related
Protein 2)2
DT2 3     L-Dopachrome Tautomerase2

External Ids:    HGNC: 27091   Entrez Gene: 16382   Ensembl: ENSG000000801667   OMIM: 1912755   UniProtKB: P401263   

Export aliases for DCT gene to outside databases

Previous GC identifers: GC13M093451 GC13M089476 GC13M093926 GC13M092789 GC13M093889 GC13M075688


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DCT Gene:
DCT (dopachrome tautomerase) is a protein-coding gene. Diseases associated with DCT include enamel caries, and amelanotic melanoma. GO annotations related to this gene include oxidoreductase activity and dopachrome isomerase activity. An important paralog of this gene is TYRP1.

UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
Function: Involved in regulating eumelanin and phaeomelanin levels

Gene Wiki entry for DCT (Dopachrome tautomerase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NC_018924.2  NT_009952.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCT gene promoter:
         ISGF-3   HSF1 (long)   CUTL1   LCR-F1   SRY   PPAR-gamma1   FOXO4   Chx10   HSF1short   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCT promoter sequence
   Search Chromatin IP Primers for DCT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q32

DCT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCT gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M095091:  view genomic region     (about GC identifiers)

Start:
95,089,558 bp from pter      End:
95,131,936 bp from pter
Size:
42,379 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126 (See protein sequence)
Recommended Name: L-dopachrome tautomerase precursor  
Size: 519 amino acids; 59145 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subunit: Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex (By similarity)
1 PDB 3D structure from and Proteopedia for DCT:
4HX1 (3D)    
Secondary accessions: Q09GT4
Alternative splicing: 2 isoforms:  P40126-1   P40126-2   

Explore the universe of human proteins at neXtProt for DCT: NX_P40126

Explore proteomics data for DCT at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn170, Asn178, Asn237, Asn300, Asn342, Asn377
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DCT (P40126) (see all 8)
     HSFLNGT  SFRNALEGF  ELAPIGHNR  CTGNFAGYNCG 


    See DCT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001123361.1  NP_001913.2  

    ENSEMBL proteins: 
     ENSP00000366227   ENSP00000431275   ENSP00000392762  

    DCT Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for DCT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002227 Tyrosinase
     IPR008922 Unchr_di-copper_centre

    Graphical View of Domain Structure for InterPro Entry P40126

    ProtoNet protein and cluster: P40126

    1 Blocks protein domain: IPB002227 Tyrosinase copper-binding domain signature

    UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
    Similarity: Belongs to the tyrosinase family


    DCT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYRP2_HUMAN, P40126
    Function: Involved in regulating eumelanin and phaeomelanin levels
    Catalytic activity: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate

         Genatlas biochemistry entry for DCT:
    DOPAchrome tautomerase

         Enzyme Number (IUBMB): EC 5.3.3.121 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004167dopachrome isomerase activity ISS--
    GO:0005507copper ion binding TAS8206391
    GO:0016491oxidoreductase activity IEA--
         
    DCT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DCT:
     Decreased TP53 protein express 

         4 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Dct):
     integument  nervous system  pigmentation  vision/eye 

    DCT for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCT
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCT

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    GenScript: all cDNA clones in your preferred vector (see all 2): DCT (NM_001921)
    Sino Biological Human cDNA Clone for DCT
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCT
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCT

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TYRP2_HUMAN, P40126: Melanosome membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol ISS--
    GO:0016021integral component of membrane IEA--
    GO:0033162melanosome membrane IEA--
    GO:0042470melanosome ISS--

    DCT for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCT About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Phenylalanine metabolism
    Tyrosine metabolism0.36
    3Basal cell carcinoma
    Melanogenesis0.32
    4Neural Crest Differentiation
    Neural Crest Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DCT
        Neural Crest Differentiation



    3 Kegg Pathways  (Kegg details for DCT):
        Tyrosine metabolism
    Metabolic pathways
    Melanogenesis

    UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
    Pathway: Pigment biosynthesis; melanin biosynthesis


    DCT for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCT
    Interactions:

        GeneGlobe Interaction Network for DCT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DCT (P401263 ENSP000003927624) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCLP182063I2D: score=1 
    TYRP1ENSP000003735704STRING: ENSP00000373570
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002052positive regulation of neuroblast proliferation IEA--
    GO:0006583melanin biosynthetic process from tyrosine ISS--
    GO:0008152metabolic process ----
    GO:0008544epidermis development TAS8206391
    GO:0021847ventricular zone neuroblast division IEA--

    DCT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCT (TYRP2)

    3 HMDB Compounds for DCT    About this table
    CompoundSynonyms CAS #PubMed Ids
    5,6-DihydroxyindoleDHI;dopaminochrome (see all 2)3131-52-0--
    5,6-Dihydroxyindole-2-carboxylic acid5,6-Dhica (see all 10)4790-08-3--
    L-Dopachrome2-L-carboxy-2,3-dihydroindole-5,6-quinone (see all 2)89762-39-0--

    Selected Novoseek inferred chemical compound relationships for DCT gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopachrome 98.3 192 1511683 (5), 9794786 (4), 11851878 (3), 1859367 (3) (see all 87)
    l-dopachrome 91.8 12 7980602 (1), 9794786 (1), 9756992 (1), 11095412 (1) (see all 7)
    dhica 91 16 12753395 (2), 1511683 (2), 7761345 (1), 7659683 (1) (see all 11)
    eumelanin 85.8 12 7761345 (1), 12753395 (1), 19449448 (1), 7567792 (1) (see all 8)
    5,6-dihydroxyindole 84.2 12 1511683 (2), 18435614 (1), 1958700 (1), 9792924 (1) (see all 5)
    dopaquinone 79 1 11041367 (1)
    levodopa 54.7 14 11180971 (1), 11549110 (1), 7659681 (1), 1511683 (1) (see all 7)
    hmba 51.1 7 11310793 (3), 10080955 (1)
    arbutin 44.9 4 9711535 (2), 10625956 (1)
    ibmx 40.9 2 7533905 (1), 9730320 (1)



    DCT for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCT gene (2 alternative transcripts): 
    NM_001129889.1  NM_001922.3  

    Unigene Cluster for DCT:

    Dopachrome tautomerase
    Hs.301865  [show with all ESTs]
    Unigene Representative Sequence: AJ000503
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377028 ENST00000483392 ENST00000490854 ENST00000472871 ENST00000446125(uc010afh.3 uc001vlv.4)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QuantiFast Probe-based Assays in human, mouse, rat DCT

    Additional mRNA sequence: 

    AF339808.1 AJ000503.1 AJ132932.1 AJ132933.1 AK293115.1 BC028311.1 BC104476.1 D17547.1 
    DQ902581.1 L18967.1 S69231.1 

    9 DOTS entries:

    DT.99948931  DT.412293  DT.95374172  DT.95286125  DT.95374169  DT.95374171  DT.100029468  DT.100686319 
    DT.95374176 

    Selected AceView cDNA sequences (see all 166):

    NM_001922 BU167938 AA133791 BG575766 AJ132933 BC028311 T27889 L18967 
    CA397323 N21337 BU193691 CA392056 BF725057 BQ427918 BQ877690 BP361881 
    BX092436 BM718524 BU163128 BQ678610 BQ679285 BM710730 BU162667 AA478687 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCT (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -     -                 -                       -                     
    SP2:        -     -     -     -     -                 -                                             
    SP3:                          -     -                                                               
    SP4:                                -                                                               
    SP5:                                                  -                                             


    ECgene alternative splicing isoforms for DCT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DCT Expression
    About this image


    DCT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Melanocytes (Integumentary System)    fully expand to see all 5 entries
             Melanocytes-like cells
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
     
     NULL (Integumentary System)
             skin 1 ; melanocytes   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Cerebellum
    DCT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301865
        Custom PCR Arrays for DCT
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    QuantiFast Probe-based Assays in human, mouse, rat DCT
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DCT gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dct1 , 5 dopachrome tautomerase1, 5 82.66(n)1
    83.56(a)1
      14 (61.60 cM)5
    131901  NM_010024.31  NP_034154.21 
     1180127925 
    chicken
    (Gallus gallus)
    Aves DCT1 dopachrome tautomerase (dopachrome delta-isomerase, more 70.91(n)
    69.88(a)
      395775  NM_204935.1  NP_990266.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCT6
    dopachrome tautomerase
    68(a)
    1 ↔ 1
    3(84712626-84745796)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.125402 Xenopus laevis transcribed sequence with weak similarity more 73.88(n)    CB558792.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dct2 dopachrome tautomerase 72.33(n)   58074  AF280090.1 


    ENSEMBL Gene Tree for DCT (if available)
    TreeFam Gene Tree for DCT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCT gene
    TYRP12  TYR2  
    3 SIMAP similar genes for DCT using alignment to 2 protein entries:     TYRP2_HUMAN (see all proteins):
    TRP-2    TYRP1    TYR

    DCT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCT (see all 976)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs95164131,2
    C,F,A,H--95091347(+) AGTAGC/TATATC 2 -- ds5001 ese332Minor allele frequency- N:0.00EA NA NS WA CSA 2981
    rs1142290541,2
    C--95091361(+) TAACCA/GGGAAA 2 -- ds50010--------
    rs1930987381,2
    --95091363(+) ACCAGA/GAAACT 2 -- ds50010--------
    rs1429870551,2
    C--95091372(+) CTCTAC/TAATTT 2 -- ds50010--------
    rs1473164061,2
    --95091400(+) ATCACC/TATAGA 2 -- ds50010--------
    rs412758761,2
    --95091427(+) CTATTC/GAATCC 2 -- ds50010--------
    rs784076451,2
    C,F--95091439(+) GTAATA/GTAGGT 2 -- ds50012Minor allele frequency- G:0.19CSA WA 120
    rs1857490931,2
    --95091505(+) TAGAGC/TGGAAT 2 -- ds50010--------
    rs779135681,2
    C--95091516(+) TGATCC/GTTCAT 2 -- ds50010--------
    rs799294431,2
    C--95091518(+) ATCCTG/TCATTT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DCT (95089558 - 95131936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DCT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1133CNV Insertion18451855
    esv34004CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCT
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 191275    OMIM disorders: --

    Selected diseases for DCT (see all 21):    
    About MalaCards
    enamel caries    amelanotic melanoma    vitiligo    chediak-higashi syndrome
    oculocutaneous albinism    vogt-koyanagi-harada disease    albinism    microphthalmia
    malignant glioma    hermansky-pudlak syndrome    glioblastoma multiforme    cholera
    graves' disease    hypothyroidism    stomatitis    melanoma
    retinoblastoma    retinitis    cerebritis    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for DCT:
    Melanoma     Vitiligo     Microphthalmia     Oculocutaneous albinism

    DCT for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for DCT gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 82.4 187 9809996 (5), 10897046 (4), 8789739 (4), 9856813 (4) (see all 86)
    melanoma b16 79.3 16 9053445 (2), 10728600 (2), 10078966 (1), 11434569 (1) (see all 10)
    melanoma cloudman s91 77.3 2 10614575 (1)
    vitiligo 75.4 21 9328128 (5), 9856813 (2), 19284502 (2), 16946711 (1) (see all 6)
    microphthalmia 70.7 12 9447965 (2), 8752668 (1), 16197942 (1), 11277492 (1) (see all 7)
    melanoma amelanotic 56.8 1 9877098 (1)
    albinism 35.8 1 8433006 (1)
    tumors 35 28 9053445 (2), 12747770 (2), 12843792 (2), 8976176 (2) (see all 21)
    autoimmunity 34.3 3 12747770 (1), 16185524 (1), 18480980 (1)
    glioblastoma multiforme 27.3 5 17004103 (1), 12843792 (1), 9176405 (1), 9792924 (1)

    Genetic Association Database (GAD): DCT
    Human Genome Epidemiology (HuGE) Navigator: DCT (4 documents)

    Export disorders for DCT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCT gene, integrated from 10 sources (see all 275):
    (articles sorted by number of sources associating them with DCT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. (PubMed id 8306979)1, 2, 3, 9 Bouchard B.... Dubertret L. (Eur. J. Biochem. 1994)
    2. Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression. (PubMed id 7929451)1, 2, 9 Yokoyama K.... Shibahara S. (J. Biol. Chem. 1994)
    3. Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy. (PubMed id 11777994)1, 2, 9 Khong H.T. and Rosenberg S.A. (J. Immunol. 2002)
    4. Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. (PubMed id 8148378)1, 2, 9 Yokoyama K.... Shibahara S. (Biochim. Biophys. Acta 1994)
    5. Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. (PubMed id 8530077)1, 2, 9 Sturm R.A.... Dunn I.S. (Genomics 1995)
    6. Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA. (PubMed id 8206391)1, 2, 9 Cassady J.L. and Sturm R.A. (Gene 1994)
    7. [Association study of Trp2 allele polymorphism with degenerative disc disease in a Chinese Han nationality]. (PubMed id 20356546)1, 4 Song H.F....Qiu G.X. (Zhonghua Yi Xue Za Zhi 2010)
    8. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (J. Proteome Res. 2006)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1638 HGNC: 2709 AceView: DCT Ensembl:ENSG00000080166 euGenes: HUgn1638
    ECgene: DCT Kegg: 1638 H-InvDB: DCT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DCT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DCT gene:
    Search GeneIP for patents involving DCT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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