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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCT Gene

protein-coding   GIFtS: 61
GCID: GC13M095091

Dopachrome Tautomerase

(Previous name: tyrosine-related protein 2)
(Previous symbol: TYRP2)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dopachrome Tautomerase1 2     TRP-22 3
TYRP21 2 3 5     TRP22 3
Tyrosine-Related Protein 21 2     L-Dopachrome Delta-Isomerase2 3
Dopachrome Delta-Isomerase1 2     EC 5.3.3.123 8
Tyrosinase-Related Protein 22 3     Dopachrome Tautomerase (Dopachrome Delta-Isomerase, Tyrosine-Related
Protein 2)2
DT2 3     L-Dopachrome Tautomerase2

External Ids:    HGNC: 27091   Entrez Gene: 16382   Ensembl: ENSG000000801667   OMIM: 1912755   UniProtKB: P401263   

Export aliases for DCT gene to outside databases

Previous GC identifers: GC13M093451 GC13M089476 GC13M093926 GC13M092789 GC13M093889 GC13M075688


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DCT Gene: 
DCT (dopachrome tautomerase) is a protein-coding gene. Diseases associated with DCT include enamel caries, and amelanotic melanoma, and among its related super-pathways are Metabolism and Phenylalanine metabolism. GO annotations related to this gene include oxidoreductase activity and dopachrome isomerase activity. An important paralog of this gene is TYRP1.

UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
Function: Involved in regulating eumelanin and phaeomelanin levels

Gene Wiki entry for DCT (Dopachrome tautomerase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCT gene promoter:
         ISGF-3   HSF1 (long)   CUTL1   LCR-F1   SRY   PPAR-gamma1   FOXO4   Chx10   HSF1short   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCT promoter sequence
   Search SABiosciences Chromatin IP Primers for DCT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q32

DCT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCT gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M095091:  view genomic region     (about GC identifiers)

Start:
95,089,558 bp from pter      End:
95,131,936 bp from pter
Size:
42,379 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126 (See protein sequence)
Recommended Name: L-dopachrome tautomerase precursor  
Size: 519 amino acids; 59145 Da
Cofactor: Binds 2 zinc ions per subunit (By similarity)
Subunit: Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex (By similarity)
Subcellular location: Melanosome membrane; Single-pass type I membrane protein
Secondary accessions: Q09GT4
Alternative splicing: 2 isoforms:  P40126-1   P40126-2   

Explore the universe of human proteins at neXtProt for DCT: NX_P40126

Explore proteomics data for DCT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P40126

  • 4/8 DME Specific Peptides for DCT (P40126) (see all 8)
     HSFLNGT  SFRNALEGF  ELAPIGHNR  CTGNFAGYNCG 

    DCT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCT Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001123361.1  NP_001913.2  

    ENSEMBL proteins: 
     ENSP00000366227   ENSP00000431275   ENSP00000392762  

    Human Recombinant Protein Products for DCT: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for DCT 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol ISS--
    GO:0016021integral to membrane IEA--
    GO:0033162melanosome membrane IEA--
    GO:0042470melanosome ISS--

    DCT for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for DCT


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR002227 Tyrosinase
     IPR008922 Unchr_di-copper_centre

    Graphical View of Domain Structure for InterPro Entry P40126

    ProtoNet protein and cluster: P40126

    1 Blocks protein domain: IPB002227 Tyrosinase copper-binding domain signature

    UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
    Similarity: Belongs to the tyrosinase family


    DCT for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TYRP2_HUMAN, P40126
    Function: Involved in regulating eumelanin and phaeomelanin levels
    Catalytic activity: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate

         Genatlas biochemistry entry for DCT:
    DOPAchrome tautomerase

         Enzyme Number (IUBMB): EC 5.3.3.121 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004167dopachrome isomerase activity ISS--
    GO:0005507copper ion binding TAS8206391
    GO:0016491oxidoreductase activity IEA--
         
    DCT for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DCT:
     Decreased TP53 protein express 

         4 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Dct):
     integument  nervous system  pigmentation  vision/eye 

    DCT for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCT 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DCT About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Phenylalanine metabolism
    Tyrosine metabolism0.36
    3Basal cell carcinoma
    Melanogenesis0.32
    4Neural Crest Differentiation
    Neural Crest Differentiation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DCT
        Neural Crest Differentiation



    3         Kegg Pathways  (Kegg details for DCT):
        Tyrosine metabolism
    Metabolic pathways
    Melanogenesis

    UniProtKB/Swiss-Prot: TYRP2_HUMAN, P40126
    Pathway: Pigment biosynthesis; melanin biosynthesis


    DCT for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DCT

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DCT (P401263 ENSP000003927624) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    VCLP182063I2D: score=1 
    TYRP1ENSP000003735704STRING: ENSP00000373570
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002052positive regulation of neuroblast proliferation IEA--
    GO:0006583melanin biosynthetic process from tyrosine ISS--
    GO:0008152metabolic process ----
    GO:0008544epidermis development TAS8206391
    GO:0021847ventricular zone neuroblast division IEA--

    DCT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DCT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCT (TYRP2)

    3 HMDB Compounds for DCT    About this table
    CompoundSynonyms CAS #PubMed Ids
    5,6-DihydroxyindoleDHI;dopaminochrome (see all 2)3131-52-0--
    5,6-Dihydroxyindole-2-carboxylic acid5,6-Dhica (see all 10)4790-08-3--
    L-Dopachrome2-L-carboxy-2,3-dihydroindole-5,6-quinone (see all 2)89762-39-0--

    10/28 Novoseek inferred chemical compound relationships for DCT gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dopachrome 98.3 192 1511683 (5), 9794786 (4), 11851878 (3), 1859367 (3) (see all 87)
    l-dopachrome 91.8 12 7980602 (1), 9794786 (1), 9756992 (1), 11095412 (1) (see all 7)
    dhica 91 16 12753395 (2), 1511683 (2), 7761345 (1), 7659683 (1) (see all 11)
    eumelanin 85.8 12 7761345 (1), 12753395 (1), 19449448 (1), 7567792 (1) (see all 8)
    5,6-dihydroxyindole 84.2 12 1511683 (2), 18435614 (1), 1958700 (1), 9792924 (1) (see all 5)
    dopaquinone 79 1 11041367 (1)
    levodopa 54.7 14 11180971 (1), 11549110 (1), 7659681 (1), 1511683 (1) (see all 7)
    hmba 51.1 7 11310793 (3), 10080955 (1)
    arbutin 44.9 4 9711535 (2), 10625956 (1)
    ibmx 40.9 2 7533905 (1), 9730320 (1)

    Search CenterWatch for drugs/clinical trials and news about DCT / TYRP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCT gene (2 alternative transcripts): 
    NM_001129889.1  NM_001922.3  

    Unigene Cluster for DCT:

    Dopachrome tautomerase
    Hs.301865  [show with all ESTs]
    Unigene Representative Sequence: AJ000503
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377028 ENST00000483392 ENST00000490854 ENST00000472871 ENST00000446125(uc010afh.3 uc001vlv.4)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF339808.1 AJ000503.1 AJ132932.1 AJ132933.1 AK293115.1 BC028311.1 BC104476.1 D17547.1 
    DQ902581.1 L18967.1 S69231.1 

    9 DOTS entries:

    DT.99948931  DT.412293  DT.95374172  DT.95286125  DT.95374169  DT.95374171  DT.100029468  DT.100686319 
    DT.95374176 

    24/166 AceView cDNA sequences (see all 166):

    N40084 BU193691 BM718524 BQ427918 BQ678610 BQ893303 BU162667 T27889 
    BU166772 BC028311 BX092436 AJ132933 BI862375 N21337 BQ877690 BG575766 
    AA478687 CA392056 NM_001922 CA397323 AA804662 BF725057 L18967 BQ681211 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DCT (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                          -     -                 -                       -                     
    SP2:        -     -     -     -     -                 -                                             
    SP3:                          -     -                                                               
    SP4:                                -                                                               
    SP5:                                                  -                                             


    ECgene alternative splicing isoforms for DCT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCT expression in normal human tissues (normalized intensities)      DCT embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DCT Expression
    About this image


    DCT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Endothelial Cells Blood Brain Barrier
             Thalamus
             Septum   
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
             sensory organ/eye/cornea   
     
     Melanocytes (Integumentary System)    fully expand to see all 4 entries
             skin ; melanocytes   
     
     Epidermis (Integumentary System)    fully expand to see all 4 entries
             vulva/anal skin ; epidermal cells   
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             heart/valve   

    See DCT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCT

    SOURCE GeneReport for Unigene cluster: Hs.301865
        SABiosciences Custom PCR Arrays for DCT
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DCT gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dct1 , 5 dopachrome tautomerase1, 5 82.66(n)1
    83.56(a)1
      14 (61.60 cM)5
    131901  NM_010024.31  NP_034154.21 
     1180127925 
    chicken
    (Gallus gallus)
    Aves DCT1 dopachrome tautomerase (dopachrome delta-isomerase, more 70.91(n)
    69.88(a)
      395775  NM_204935.1  NP_990266.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCT6
    Uncharacterized protein
    67(a)
    1 ↔ 1
    3(84712626-84745796)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.125402 Xenopus laevis transcribed sequence with weak similarity more 73.88(n)    CB558792.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dct2 dopachrome tautomerase 72.33(n)   58074  AF280090.1 


    ENSEMBL Gene Tree for DCT (if available)
    TreeFam Gene Tree for DCT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCT gene
    TYRP12  TYR2  
    3 SIMAP similar genes for DCT using alignment to 3 protein entries:     TYRP2_HUMAN (see all proteins):
    TRP-2    TYRP1    TYR

    DCT for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/976 SNPs in DCT are shown (see all 976)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs95164131,2
    C,F,A,H--95091347(+) AGTAGC/TATATC 2 -- ds5001 ese332Minor allele frequency- N:0.00EA NA NS WA CSA 2981
    rs1142290541,2
    C--95091361(+) TAACCA/GGGAAA 2 -- ds50010--------
    rs1930987381,2
    --95091363(+) ACCAGA/GAAACT 2 -- ds50010--------
    rs1429870551,2
    C--95091372(+) CTCTAC/TAATTT 2 -- ds50010--------
    rs1473164061,2
    --95091400(+) ATCACC/TATAGA 2 -- ds50010--------
    rs412758761,2
    --95091427(+) CTATTC/GAATCC 2 -- ds50010--------
    rs784076451,2
    C,F--95091439(+) GTAATA/GTAGGT 2 -- ds50012Minor allele frequency- G:0.19CSA WA 120
    rs1857490931,2
    --95091505(+) TAGAGC/TGGAAT 2 -- ds50010--------
    rs779135681,2
    C--95091516(+) TGATCC/GTTCAT 2 -- ds50010--------
    rs799294431,2
    C--95091518(+) ATCCTG/TCATTT 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for DCT (95089558 - 95131936 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DCT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1133CNV Insertion18451855
    esv34004CNV Loss18971310

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191275    OMIM disorders: --

    20 diseases for DCT:    About MalaCards
    enamel caries    amelanotic melanoma    oculocutaneous albinism    chediak-higashi syndrome
    vitiligo    malignant glioma    vogt-koyanagi-harada disease    albinism
    hermansky-pudlak syndrome    microphthalmia    cholera    glioblastoma
    stomatitis    retinoblastoma    hypothyroidism    melanoma
    graves' disease    non-small cell lung carcinoma    retinitis    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for DCT:
    Melanoma     Vitiligo     Microphthalmia     Oculocutaneous albinism

    DCT for disorders           About GeneDecksing

    10/22 Novoseek inferred disease relationships for DCT gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 82.4 187 9809996 (5), 10897046 (4), 8789739 (4), 9856813 (4) (see all 86)
    melanoma b16 79.3 16 9053445 (2), 10728600 (2), 10078966 (1), 11434569 (1) (see all 10)
    melanoma cloudman s91 77.3 2 10614575 (1)
    vitiligo 75.4 21 9328128 (5), 9856813 (2), 19284502 (2), 16946711 (1) (see all 6)
    microphthalmia 70.7 12 9447965 (2), 8752668 (1), 16197942 (1), 11277492 (1) (see all 7)
    melanoma amelanotic 56.8 1 9877098 (1)
    albinism 35.8 1 8433006 (1)
    tumors 35 28 9053445 (2), 12747770 (2), 12843792 (2), 8976176 (2) (see all 21)
    autoimmunity 34.3 3 12747770 (1), 16185524 (1), 18480980 (1)
    glioblastoma multiforme 27.3 5 17004103 (1), 12843792 (1), 9176405 (1), 9792924 (1)

    Genetic Association Database (GAD): DCT
    Human Genome Epidemiology (HuGE) Navigator: DCT (4 documents)

    Export disorders for DCT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCT gene, integrated from 9 sources (see all 275):
    (articles sorted by number of sources associating them with DCT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. (PubMed id 8306979)1, 2, 3, 9 Bouchard B.... Dubertret L. (1994)
    2. Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression. (PubMed id 7929451)1, 2, 9 Yokoyama K.... Shibahara S. (1994)
    3. Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy. (PubMed id 11777994)1, 2, 9 Khong H.T. and Rosenberg S.A. (2002)
    4. Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. (PubMed id 8148378)1, 2, 9 Yokoyama K.... Shibahara S. (1994)
    5. Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. (PubMed id 8530077)1, 2, 9 Sturm R.A.... Dunn I.S. (1995)
    6. Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA. (PubMed id 8206391)1, 2, 9 Cassady J.L. and Sturm R.A. (1994)
    7. [Association study of Trp2 allele polymorphism with d egenerative disc disease in a Chinese Han nationality] (PubMed id 20356546)1, 4 Song H.F....Qiu G.X. (2010)
    8. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PubMed id 17081065)1, 2 Chi A....Hunt D.F. (2006)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1638 HGNC: 2709 AceView: DCT Ensembl:ENSG00000080166 euGenes: HUgn1638
    ECgene: DCT Kegg: 1638 H-InvDB: DCT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCT gene:
    Search GeneIP for patents involving DCT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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