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Aliases for DCSTAMP Gene

Aliases for DCSTAMP Gene

  • Dendrocyte Expressed Seven Transmembrane Protein 2 3
  • Transmembrane 7 Superfamily Member 4 2 3 4
  • TM7SF4 3 4 6
  • FIND 3 4 6
  • Dendritic Cells (DC)-Specific Transmembrane Protein 2 3
  • Dendrocyte-Expressed Seven Transmembrane Protein 3 4
  • IL-Four-Induced Protein 3 4
  • IL-Four INDuced 2 3
  • HDC-STAMP 3 4
  • Dendritic Cell-Specific Transmembrane Protein 3
  • DC-Specific Transmembrane Protein 3
  • IL-Four (IL-4) Induced 3
  • IL-4-Induced Protein 3
  • DC-STAMP 4

External Ids for DCSTAMP Gene

Previous HGNC Symbols for DCSTAMP Gene

  • TM7SF4

Previous GeneCards Identifiers for DCSTAMP Gene

  • GC08P105420
  • GC08P105020
  • GC08P105308

Summaries for DCSTAMP Gene

Entrez Gene Summary for DCSTAMP Gene

  • This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for DCSTAMP Gene

DCSTAMP (Dendrocyte Expressed Seven Transmembrane Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCSTAMP Gene

  • Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCSTAMP Gene

Genomics for DCSTAMP Gene

Genomic Location for DCSTAMP Gene

Start:
104,339,087 bp from pter
End:
104,356,689 bp from pter
Size:
17,603 bases
Orientation:
Plus strand

Genomic View for DCSTAMP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCSTAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCSTAMP Gene

No data available for Regulatory Elements for DCSTAMP Gene

Proteins for DCSTAMP Gene

  • Protein details for DCSTAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H295-DCSTP_HUMAN
    Recommended name:
    Dendritic cell-specific transmembrane protein
    Protein Accession:
    Q9H295
    Secondary Accessions:
    • B7ZVW2
    • E7ESG0
    • Q2M2D5

    Protein attributes for DCSTAMP Gene

    Size:
    470 amino acids
    Molecular mass:
    53393 Da
    Quaternary structure:
    • Monomer. Homodimer. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 1 (via the C-terminus tail); the interaction induces DCSTAMP redistribution to the endoplasmic reticulum-Golgi intermediate compartment. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 2 (via the C-terminus tail) (By similarity). Interacts with CREB3.

    Alternative splice isoforms for DCSTAMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCSTAMP Gene

Proteomics data for DCSTAMP Gene at MOPED

Post-translational modifications for DCSTAMP Gene

Other Protein References for DCSTAMP Gene

No data available for DME Specific Peptides for DCSTAMP Gene

Domains for DCSTAMP Gene

Protein Domains for DCSTAMP Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H295

UniProtKB/Swiss-Prot:

DCSTP_HUMAN :
  • Q9H295
Domain:
  • Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport (By similarity).
genes like me logo Genes that share domains with DCSTAMP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for DCSTAMP Gene

Function for DCSTAMP Gene

Molecular function for DCSTAMP Gene

UniProtKB/Swiss-Prot Function: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions
UniProtKB/Swiss-Prot Induction: Expression is down-regulated by dexamethasone and up-regulated by IL4/interleukin-4 in macrophages. Down-regulated in CD40L-activated dendritic cells.

Gene Ontology (GO) - Molecular Function for DCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20546900
GO:0005524 ATP binding --
GO:0042626 ATPase activity, coupled to transmembrane movement of substances --
genes like me logo Genes that share ontologies with DCSTAMP: view

Phenotypes for DCSTAMP Gene

genes like me logo Genes that share phenotypes with DCSTAMP: view

Animal Model Products

CRISPR Products

miRNA for DCSTAMP Gene

miRTarBase miRNAs that target DCSTAMP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCSTAMP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCSTAMP Gene

Localization for DCSTAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCSTAMP Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endosome. Note=Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for DCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 15601667
GO:0005887 integral component of plasma membrane IDA 20586129
GO:0009986 cell surface IDA 11169400
GO:0010008 endosome membrane ISS --
GO:0016021 integral component of membrane NAS 11169400
genes like me logo Genes that share ontologies with DCSTAMP: view

No data available for Subcellular locations from COMPARTMENTS for DCSTAMP Gene

Pathways for DCSTAMP Gene

SuperPathways for DCSTAMP Gene

No Data Available

Interacting Proteins for DCSTAMP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297581%0d%0a9606.ENSP00000318165%0d%0a9606.ENSP00000342136%0d%0a
Selected Interacting proteins: ENSP00000297581 Q9H295-DCSTP_HUMAN for DCSTAMP Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for DCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport --
GO:0030308 negative regulation of cell growth ISS --
GO:0030316 osteoclast differentiation ISS --
GO:0034241 positive regulation of macrophage fusion ISS --
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus ISS --
genes like me logo Genes that share ontologies with DCSTAMP: view

No data available for Pathways by source for DCSTAMP Gene

Transcripts for DCSTAMP Gene

mRNA/cDNA for DCSTAMP Gene

Unigene Clusters for DCSTAMP Gene

Dendrocyte expressed seven transmembrane protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCSTAMP

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCSTAMP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - -
SP2:
SP3:
SP4: -

Relevant External Links for DCSTAMP Gene

GeneLoc Exon Structure for
DCSTAMP
ECgene alternative splicing isoforms for
DCSTAMP

Expression for DCSTAMP Gene

mRNA expression in normal human tissues for DCSTAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCSTAMP Gene

This gene is overexpressed in Brain - Amygdala (17.9), Lung (9.4), and Adipose - Subcutaneous (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DCSTAMP Gene

SOURCE GeneReport for Unigene cluster for DCSTAMP Gene Hs.652230

mRNA Expression by UniProt/SwissProt for DCSTAMP Gene

Q9H295-DCSTP_HUMAN
Tissue specificity: Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs. Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes.
genes like me logo Genes that share expressions with DCSTAMP: view

In Situ Assay Products

Orthologs for DCSTAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCSTAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCSTAMP 36
  • 99 (a)
OneToOne
TM7SF4 35
  • 99.72 (n)
  • 99.36 (a)
cow
(Bos Taurus)
Mammalia DCSTAMP 35
  • 83.23 (n)
  • 78.46 (a)
DCSTAMP 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCSTAMP 36
  • 78 (a)
OneToOne
TM7SF4 35
  • 84.54 (n)
  • 77.99 (a)
mouse
(Mus musculus)
Mammalia Dcstamp 35
  • 79.42 (n)
  • 74.57 (a)
Dcstamp 16
Dcstamp 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCSTAMP 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCSTAMP 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcstamp 35
  • 78.07 (n)
  • 72.7 (a)
chicken
(Gallus gallus)
Aves DCSTAMP 35
  • 56.92 (n)
  • 47.1 (a)
DCSTAMP 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCSTAMP 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcstamp 35
  • 50.74 (n)
  • 36.36 (a)
zebrafish
(Danio rerio)
Actinopterygii DCSTAMP 36
  • 32 (a)
OneToOne
LOC101883335 35
  • 45.71 (n)
  • 32.47 (a)
Species with no ortholog for DCSTAMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCSTAMP Gene

ENSEMBL:
Gene Tree for DCSTAMP (if available)
TreeFam:
Gene Tree for DCSTAMP (if available)

Paralogs for DCSTAMP Gene

No data available for Paralogs for DCSTAMP Gene

Variants for DCSTAMP Gene

Sequence variations from dbSNP and Humsavar for DCSTAMP Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1513027 -- 104,349,946(-) CATCG(C/G)GCACT intron-variant
rs1810113 -- 104,352,366(+) GATAA(C/T)GGAAG intron-variant
rs2002812 -- 104,353,006(-) TGGCA(A/G)CACCT intron-variant
rs2251930 -- 104,345,536(-) GAACA(C/T)GTTTT intron-variant
rs2458412 -- 104,351,673(-) GTTGT(C/G)TTACA intron-variant

Relevant External Links for DCSTAMP Gene

HapMap Linkage Disequilibrium report
DCSTAMP
Human Gene Mutation Database (HGMD)
DCSTAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCSTAMP Gene

Disorders for DCSTAMP Gene

No disorders were found for DCSTAMP Gene.

No data available for UniProtKB/Swiss-Prot for DCSTAMP Gene

Publications for DCSTAMP Gene

  1. DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. (PMID: 11169400) Hartgers F.C. … Adema G.J. (Eur. J. Immunol. 2000) 2 3 4 23
  2. The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. (PMID: 15601667) Eleveld-Trancikova D. … Adema G.J. (J. Leukoc. Biol. 2005) 3 4 23
  3. OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. (PMID: 18952287) Jansen B.J. … Adema G.J. (Mol. Immunol. 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages. (PMID: 11345586) Staege H. … Schaffner A. (Immunogenetics 2001) 3 4

Products for DCSTAMP Gene

Sources for DCSTAMP Gene

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