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Aliases for DCSTAMP Gene

Aliases for DCSTAMP Gene

  • Dendrocyte Expressed Seven Transmembrane Protein 2 3 5
  • Transmembrane 7 Superfamily Member 4 2 3 4
  • Dendritic Cells (DC)-Specific Transmembrane Protein 2 3
  • Dendrocyte-Expressed Seven Transmembrane Protein 3 4
  • IL-Four-Induced Protein 3 4
  • IL-Four INDuced 2 3
  • HDC-STAMP 3 4
  • TM7SF4 3 4
  • FIND 3 4
  • DC-Specific Transmembrane Protein 3
  • IL-Four (IL-4) Induced 3
  • IL-4-Induced Protein 3
  • DC-STAMP 4

External Ids for DCSTAMP Gene

Previous HGNC Symbols for DCSTAMP Gene

  • TM7SF4

Previous GeneCards Identifiers for DCSTAMP Gene

  • GC08P105420
  • GC08P105020
  • GC08P105308

Summaries for DCSTAMP Gene

Entrez Gene Summary for DCSTAMP Gene

  • This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for DCSTAMP Gene

DCSTAMP (Dendrocyte Expressed Seven Transmembrane Protein) is a Protein Coding gene. Diseases associated with DCSTAMP include Paget's Disease Of Bone and Papillon-Lefevre Syndrome. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.

UniProtKB/Swiss-Prot for DCSTAMP Gene

  • Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCSTAMP Gene

Genomics for DCSTAMP Gene

Regulatory Elements for DCSTAMP Gene

Enhancers for DCSTAMP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCSTAMP on UCSC Golden Path with GeneCards custom track

Promoters for DCSTAMP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCSTAMP on UCSC Golden Path with GeneCards custom track

Genomic Location for DCSTAMP Gene

Chromosome:
8
Start:
104,339,087 bp from pter
End:
104,356,689 bp from pter
Size:
17,603 bases
Orientation:
Plus strand

Genomic View for DCSTAMP Gene

Genes around DCSTAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCSTAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCSTAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCSTAMP Gene

Proteins for DCSTAMP Gene

  • Protein details for DCSTAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H295-DCSTP_HUMAN
    Recommended name:
    Dendritic cell-specific transmembrane protein
    Protein Accession:
    Q9H295
    Secondary Accessions:
    • B7ZVW2
    • E7ESG0
    • Q2M2D5

    Protein attributes for DCSTAMP Gene

    Size:
    470 amino acids
    Molecular mass:
    53393 Da
    Quaternary structure:
    • Monomer. Homodimer. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 1 (via the C-terminus tail); the interaction induces DCSTAMP redistribution to the endoplasmic reticulum-Golgi intermediate compartment. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 2 (via the C-terminus tail) (By similarity). Interacts with CREB3.

    Alternative splice isoforms for DCSTAMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCSTAMP Gene

Proteomics data for DCSTAMP Gene at MOPED

Post-translational modifications for DCSTAMP Gene

Other Protein References for DCSTAMP Gene

Antibody Products

No data available for DME Specific Peptides for DCSTAMP Gene

Domains & Families for DCSTAMP Gene

Protein Domains for DCSTAMP Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DCSTAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H295

UniProtKB/Swiss-Prot:

DCSTP_HUMAN :
  • Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport (By similarity).
Domain:
  • Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport (By similarity).
genes like me logo Genes that share domains with DCSTAMP: view

No data available for Gene Families for DCSTAMP Gene

Function for DCSTAMP Gene

Molecular function for DCSTAMP Gene

UniProtKB/Swiss-Prot Function:
Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
UniProtKB/Swiss-Prot Induction:
Expression is down-regulated by dexamethasone and up-regulated by IL4/interleukin-4 in macrophages. Down-regulated in CD40L-activated dendritic cells.
genes like me logo Genes that share phenotypes with DCSTAMP: view

Animal Models for DCSTAMP Gene

MGI Knock Outs for DCSTAMP:

Animal Model Products

  • Taconic Biosciences Mouse Models for DCSTAMP

miRNA for DCSTAMP Gene

miRTarBase miRNAs that target DCSTAMP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCSTAMP Gene

Localization for DCSTAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCSTAMP Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endosome. Note=Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCSTAMP Gene COMPARTMENTS Subcellular localization image for DCSTAMP gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
endosome 4
nucleus 2
vacuole 1

Gene Ontology (GO) - Cellular Components for DCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 15601667
GO:0016021 integral component of membrane IEA,NAS 11169400
GO:0030176 integral component of endoplasmic reticulum membrane IDA 20546900
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA --
genes like me logo Genes that share ontologies with DCSTAMP: view

Pathways & Interactions for DCSTAMP Gene

SuperPathways for DCSTAMP Gene

No Data Available

Interacting Proteins for DCSTAMP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297581%0d%0a9606.ENSP00000318165%0d%0a9606.ENSP00000342136%0d%0a
Selected Interacting proteins: ENSP00000297581 Q9H295-DCSTP_HUMAN for DCSTAMP Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for DCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030308 negative regulation of cell growth ISS --
GO:0030316 osteoclast differentiation ISS --
GO:0034241 positive regulation of macrophage fusion ISS --
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus ISS --
GO:0045657 positive regulation of monocyte differentiation ISS --
genes like me logo Genes that share ontologies with DCSTAMP: view

No data available for Pathways by source and SIGNOR curated interactions for DCSTAMP Gene

Drugs & Compounds for DCSTAMP Gene

No Compound Related Data Available

Transcripts for DCSTAMP Gene

mRNA/cDNA for DCSTAMP Gene

Unigene Clusters for DCSTAMP Gene

Dendrocyte expressed seven transmembrane protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCSTAMP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - -
SP2:
SP3:
SP4: -

Relevant External Links for DCSTAMP Gene

GeneLoc Exon Structure for
DCSTAMP
ECgene alternative splicing isoforms for
DCSTAMP

Expression for DCSTAMP Gene

mRNA expression in normal human tissues for DCSTAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCSTAMP Gene

This gene is overexpressed in Brain - Amygdala (x17.9), Lung (x9.4), and Adipose - Subcutaneous (x4.2).

Protein differential expression in normal tissues from HIPED for DCSTAMP Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCSTAMP Gene



SOURCE GeneReport for Unigene cluster for DCSTAMP Gene Hs.652230

mRNA Expression by UniProt/SwissProt for DCSTAMP Gene

Q9H295-DCSTP_HUMAN
Tissue specificity: Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs. Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes.
genes like me logo Genes that share expression patterns with DCSTAMP: view

Protein tissue co-expression partners for DCSTAMP Gene

Primer Products

Orthologs for DCSTAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCSTAMP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCSTAMP 35
  • 83.23 (n)
  • 78.46 (a)
DCSTAMP 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TM7SF4 35
  • 84.54 (n)
  • 77.99 (a)
DCSTAMP 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcstamp 35
  • 79.42 (n)
  • 74.57 (a)
Dcstamp 16
Dcstamp 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TM7SF4 35
  • 99.72 (n)
  • 99.36 (a)
DCSTAMP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcstamp 35
  • 78.07 (n)
  • 72.7 (a)
oppossum
(Monodelphis domestica)
Mammalia DCSTAMP 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCSTAMP 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCSTAMP 35
  • 56.92 (n)
  • 47.1 (a)
DCSTAMP 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCSTAMP 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcstamp 35
  • 50.74 (n)
  • 36.36 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101883335 35
  • 45.71 (n)
  • 32.47 (a)
DCSTAMP 36
  • 32 (a)
OneToOne
Species with no ortholog for DCSTAMP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCSTAMP Gene

ENSEMBL:
Gene Tree for DCSTAMP (if available)
TreeFam:
Gene Tree for DCSTAMP (if available)

Paralogs for DCSTAMP Gene

No data available for Paralogs for DCSTAMP Gene

Variants for DCSTAMP Gene

Sequence variations from dbSNP and Humsavar for DCSTAMP Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs3802204 - 104,354,893(+) TCAAG(A/G)TATTA intron-variant, reference, missense
rs2251930 -- 104,345,536(-) GAACA(C/T)GTTTT intron-variant
rs2458412 -- 104,351,673(-) GTTGT(C/G)TTACA intron-variant
rs2458413 -- 104,347,204(-) AGATC(A/G)GAATA intron-variant
rs2458414 -- 104,343,612(-) TCTTA(C/T)AGGGA intron-variant

Variation tolerance for DCSTAMP Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.18; 80.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCSTAMP Gene

Human Gene Mutation Database (HGMD)
DCSTAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCSTAMP Gene

Disorders for DCSTAMP Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCSTAMP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
paget's disease of bone
  • familial paget's disease of bone
papillon-lefevre syndrome
  • papillon-lefevre disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DCSTAMP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCSTAMP
genes like me logo Genes that share disorders with DCSTAMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCSTAMP Gene

Publications for DCSTAMP Gene

  1. DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. (PMID: 11169400) Hartgers F.C. … Adema G.J. (Eur. J. Immunol. 2000) 2 3 4 23 67
  2. OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. (PMID: 18952287) Jansen B.J. … Adema G.J. (Mol. Immunol. 2009) 3 23
  3. The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. (PMID: 15601667) Eleveld-Trancikova D. … Adema G.J. (J. Leukoc. Biol. 2005) 3 23
  4. Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene. (PMID: 11345591) Hartgers F.C. … Adema G.J. (Immunogenetics 2001) 2 3
  5. Polymorphisms of CSF1 and TM7SF4 genes in a case of mild juvenile Paget's disease found using next-generation sequencing. (PMID: 25891874) DonA!th J. … PoA^r G. (Croat. Med. J. 2015) 3

Products for DCSTAMP Gene

Sources for DCSTAMP Gene

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