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DCSTAMP Gene

protein-coding   GIFtS: 44
GCID: GC08P105308

Dendrocyte Expressed Seven Transmembrane Protein

(Previous name: transmembrane 7 superfamily member 4)
(Previous symbol: TM7SF4)
  Search for DCSTAMP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dendrocyte Expressed Seven Transmembrane Protein1 2     hDC-STAMP2 3
TM7SF41 2 3 5     IL-Four-Induced Protein2 3
Transmembrane 7 Superfamily Member 41 2 3     DC-Specific Transmembrane Protein2
FIND2 3 5     Dendritic Cell-Specific Transmembrane Protein2
Dendritic Cells (DC)-Specific Transmembrane Protein1 2     IL-4-Induced Protein2
IL-Four INDuced1 2     IL-Four (IL-4) Induced2
Dendrocyte-Expressed Seven Transmembrane Protein2 3     DC-STAMP3

External Ids:    HGNC: 185491   Entrez Gene: 815012   Ensembl: ENSG000001649357   OMIM: 6059335   UniProtKB: Q9H2953   
ORGUL members:         

Export aliases for DCSTAMP gene to outside databases

Previous GC identifers: GC08P105420 GC08P105020


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCSTAMP Gene:
This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded
protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a
role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript
variants. (provided by RefSeq, Mar 2012)

GeneCards Summary for DCSTAMP Gene:
DCSTAMP (dendrocyte expressed seven transmembrane protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: DCSTP_HUMAN, Q9H295
Function: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone
and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in
modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast
bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast
precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid
lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic
cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune
self-tolerance and avoidance of autoimmune reactions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DCSTAMP
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCSTAMP promoter sequence
   Search Chromatin IP Primers for DCSTAMP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCSTAMP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.3

DCSTAMP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCSTAMP gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P105308:  view genomic region     (about GC identifiers)

Start:
105,351,315 bp from pter      End:
105,368,917 bp from pter
Size:
17,603 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCSTP_HUMAN, Q9H295 (See protein sequence)
Recommended Name: Dendritic cell-specific transmembrane protein  
Size: 470 amino acids; 53393 Da
Subunit: Monomer. Homodimer. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 1 (via the
C-terminus tail); the interaction induces DCSTAMP redistribution to the endoplasmic reticulum-Golgi intermediate
compartment. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 2 (via the C-terminus
tail) (By similarity). Interacts with CREB3
Developmental stage: Constitutively expressed in dendritic cells from day 3-8 in culture
Secondary accessions: B7ZVW2 E7ESG0 Q2M2D5
Alternative splicing: 2 isoforms:  Q9H295-1   Q9H295-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCSTAMP: NX_Q9H295

Explore proteomics data for DCSTAMP at MOPED

Post-translational modifications: 

  • Glycosylated (By similarity)1
  • Modification sites at neXtProt

  • See DCSTAMP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001244246.1  NP_110415.1  

    ENSEMBL proteins: 
     ENSP00000297581   ENSP00000428869  

    DCSTAMP Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR012858 DC_STAMP-like

    Graphical View of Domain Structure for InterPro Entry Q9H295

    ProtoNet protein and cluster: Q9H295

    1 Blocks protein domain: IPB012858 DC-STAMP-like

    UniProtKB/Swiss-Prot: DCSTP_HUMAN, Q9H295
    Domain: Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is
    necessary for interaction with OS9, is also required for its transport (By similarity)


    Find genes that share domains with DCSTAMP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCSTP_HUMAN, Q9H295
    Function: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone
    and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in
    modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast
    bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast
    precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid
    lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic
    cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune
    self-tolerance and avoidance of autoimmune reactions
    Induction: Expression is down-regulated by dexamethasone and up-regulated by IL4/interleukin-4 in macrophages.
    Down-regulated in CD40L-activated dendritic cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005524ATP binding ----
    GO:0042626ATPase activity, coupled to transmembrane movement of substances ----
         
    Find genes that share ontologies with DCSTAMP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DCSTAMP:
     Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dcstamp):
     cellular  hematopoietic system  immune system  skeleton 

    Find genes that share phenotypes with DCSTAMP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCSTAMP
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCSTP_HUMAN, Q9H295: Cell membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane;
    Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane
    protein (By similarity). Endosome (By similarity). Note=Localizes to the cell surface in osteoclasts and
    undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced
    osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC).
    Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a
    OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IDA15601667
    GO:0005887integral component of plasma membrane IDA--
    GO:0009986cell surface IDA11169400
    GO:0010008endosome membrane ISS--
    GO:0016021integral component of membrane NAS11169400

    Find genes that share ontologies with DCSTAMP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCSTAMP
    Interactions:

        Search GeneGlobe Interaction Network for DCSTAMP

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for DCSTAMP (Q9H2951 ENSP000002975814) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O43889-21, ENSP000003421364EBI-6095316,EBI-625022 STRING: ENSP00000342136
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport ----
    GO:0030308negative regulation of cell growth ISS--
    GO:0030316osteoclast differentiation ISS--
    GO:0034241positive regulation of macrophage fusion ISS--
    GO:0036006cellular response to macrophage colony-stimulating factor stimulus ISS--

    Find genes that share ontologies with DCSTAMP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCSTAMP (DCSTP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCSTAMP gene (2 alternative transcripts): 
    NM_001257317.1  NM_030788.3  

    Unigene Cluster for DCSTAMP:

    Dendrocyte expressed seven transmembrane protein
    Hs.652230  [show with all ESTs]
    Unigene Representative Sequence: NM_030788
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000519562 ENST00000517364 ENST00000518023 ENST00000297581(uc003ylx.1)
    ENST00000517991 ENST00000518051 ENST00000520080
    miRNA
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    Additional mRNA sequence: 

    AF277290.1 AF305068.1 AK095417.1 BC069349.1 BC112018.1 BC112020.1 BC171732.1 

    1 DOTS entry:

    DT.65285271 

    12 AceView cDNA sequences:

    BC069349 CD632765 CD632767 NM_030788 AK095417 AF305068 CB529594 AF277290 
    AA380009 AW450309 CD632770 AW295136 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DCSTAMP    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
    SP1:        -                 -                                 
    SP2:                                                            
    SP3:                                                            
    SP4:                          -                                 


    ECgene alternative splicing isoforms for DCSTAMP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCSTAMP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTATTGCCC
    DCSTAMP Expression
    About this image


    DCSTAMP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Osteoclasts Bone Marrow
             Zeugopod Periosteum
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    DCSTAMP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCSTAMP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652230

    UniProtKB/Swiss-Prot: DCSTP_HUMAN, Q9H295
    Tissue specificity: Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs.
    Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow,
    spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in
    freshly isolated monocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DCSTAMP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcstamp1 , 5 dentrocyte expressed seven transmembrane protein1, 5 79.42(n)1
    74.57(a)1
      15 (15.51 cM)5
    757661  NM_029422.31  NP_083698.11 
     397459325 
    chicken
    (Gallus gallus)
    Aves DCSTAMP1 dendrocyte expressed seven transmembrane protein 56.92(n)
    47.1(a)
      420265  XM_004939986.1  XP_004940043.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCSTAMP6
    dendrocyte expressed seven transmembrane protein
    42(a)
    1 ↔ 1
    4(13131239-13149733)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dcstamp1 dendrocyte expressed seven transmembrane protein 50.74(n)
    36.36(a)
      101732559  XM_004915637.1  XP_004915694.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018833351 dendritic cell-specific transmembrane protein-like 45.71(n)
    32.47(a)
      101883335  XM_005170747.1  XP_005170804.1 


    ENSEMBL Gene Tree for DCSTAMP (if available)
    TreeFam Gene Tree for DCSTAMP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCSTAMP (see all 458)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503777241,2
    --105350039(+) CTTTC-/TTCT  
            
    TTCTT
    2 -- us2k10--------
    rs2011753271,2
    C--105350041(+) TTCTTC/TTTTCT 2 -- us2k10--------
    rs2018993851,2
    C--105350042(+) TCTTCC/TTTCTT 2 -- us2k10--------
    rs38083951,2
    C,F,H--105350079(+) CTTTCG/ATGTAT 2 -- us2k17Minor allele frequency- A:0.18NS EA CSA WA 648
    rs1872939011,2
    --105350114(+) CAAACC/TGGGCC 2 -- us2k10--------
    rs746490001,2
    F--105350316(+) CTTCCC/TGAAGG 2 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1412667541,2
    --105350331(+) AGAGGA/GAGGGA 2 -- us2k10--------
    rs1454092661,2
    --105350432(+) GACATA/GTGGGT 2 -- us2k10--------
    rs1918290691,2
    --105350464(+) CAATCA/TATGCT 2 -- us2k10--------
    rs1836200861,2
    --105350530(+) ACACAC/TGTACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DCSTAMP (105351315 - 105368917 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DCSTAMP: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCSTAMP
    DNA2.0 Custom Variant and Variant Library Synthesis for DCSTAMP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605933    OMIM disorders: --


    Find genes that share disorders with DCSTAMP           About GenesLikeMe


    Export disorders for DCSTAMP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCSTAMP gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with DCSTAMP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. (PubMed id 11169400)1, 2, 3, 9 Hartgers F.C.... Adema G.J. (Eur. J. Immunol. 2000)
    2. The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. (PubMed id 15601667)1, 2, 9 Eleveld-Trancikova D....Adema G.J. (J. Leukoc. Biol. 2005)
    3. DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. (PubMed id 20546900)1, 2 Eleveld-Trancikova D.... Adema G.J. (Mol. Immunol. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Two novel genes FIND and LIND differentially expressed in deactivated and Listeria-infected human macrophages. (PubMed id 11345586)1, 2 Staege H.... Schaffner A. (Immunogenetics 2001)
    6. Genomic organization, chromosomal localization, and 5' upstream region of the human DC-STAMP gene. (PubMed id 11345591)1, 3 Hartgers F.C....Adema G.J. (Immunogenetics 2001)
    7. OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. (PubMed id 18952287)1, 9 Jansen B.J....Adema G.J. (Mol. Immunol. 2009)
    8. Lentivirus-mediated RNA interference of DC-STAMP expression inhibits the fusion and resorptive activity of human osteoclasts. (PubMed id 23525827)1 Zeng Z....Chen J. (J. Bone Miner. Metab. 2013)
    9. Regulation of human osteoclast development by dendritic cell-specific transmembrane protein (DC-STAMP). (PubMed id 21987375)1 Chiu Y.H....Ritchlin C.T. (J. Bone Miner. Res. 2012)
    10. The CD40-CD40L axis and IFN-I^ play critical roles in Langhans giant cell formation. (PubMed id 22058328)1 Sakai H....Heike T. (Int. Immunol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81501 HGNC: 18549 AceView: TM7SF4 Ensembl:ENSG00000164935 euGenes: HUgn81501
    ECgene: DCSTAMP H-InvDB: DCSTAMP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCSTAMP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCSTAMP gene:
    Search GeneIP for patents involving DCSTAMP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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