Aliases for DCSTAMP Gene
External Ids for DCSTAMP Gene
Previous HGNC Symbols for DCSTAMP Gene
Previous GeneCards Identifiers for DCSTAMP Gene
This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
GeneCards Summary for DCSTAMP Gene
DCSTAMP (Dendrocyte Expressed Seven Transmembrane Protein) is a Protein Coding gene. Diseases associated with DCSTAMP include Paget's Disease Of Bone and Papillon-Lefevre Syndrome. GO annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.
UniProtKB/Swiss-Prot for DCSTAMP Gene
Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.