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Aliases for DCST2 Gene

Aliases for DCST2 Gene

  • DC-STAMP Domain Containing 2 2 3 5

External Ids for DCST2 Gene

Previous GeneCards Identifiers for DCST2 Gene

  • GC01M151805
  • GC01M153257
  • GC01M154990
  • GC01M126352

Summaries for DCST2 Gene

GeneCards Summary for DCST2 Gene

DCST2 (DC-STAMP Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is DCST1.

Additional gene information for DCST2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCST2 Gene

Genomics for DCST2 Gene

Regulatory Elements for DCST2 Gene

Enhancers for DCST2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H154998 1.9 FANTOM5 ENCODE dbSUPER 25.7 +29.3 29330 11 MLX YBX1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ZC3H11A PPARGC1A GON4L CLK2 UBAP2L KIAA0907 ENSG00000271267 MSTO1 RUSC1-AS1 THBS3 YY1AP1 FLAD1
GH01H155242 1.5 ENCODE dbSUPER 27.7 -210.5 -210462 2 FEZF1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZFP41 MEF2D ZNF610 KIAA0907 GON4L ENSG00000271267 CLK2 MSTO1 MSTO2P THBS3 RUSC1-AS1 LOC101928120 SHC1
GH01H155015 1.7 Ensembl ENCODE dbSUPER 16.1 +16.5 16467 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 GON4L KIAA0907 UBAP2L ENSG00000271267 CLK2 MSTO1 LOC101928120 MSTO2P THBS3 PYGO2
GH01H155856 1.8 FANTOM5 ENCODE dbSUPER 10.6 -825.2 -825169 5 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 ZBTB7B GON4L KIAA0907 ENSG00000271267 RRNAD1 CLK2 THBS3 DAP3 FLAD1 PYGO2 GBA
GH01H154324 1.7 FANTOM5 ENCODE dbSUPER 10.9 +706.7 706666 5 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207 FOS ZNF548 CLK2 FLAD1 PYGO2 UBAP2L CHTOP ENSG00000272654 LOC101928120 SLC27A3 NUP210L CRTC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCST2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCST2 Gene

Chromosome:
1
Start:
155,017,448 bp from pter
End:
155,033,781 bp from pter
Size:
16,334 bases
Orientation:
Minus strand

Genomic View for DCST2 Gene

Genes around DCST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCST2 Gene

Proteins for DCST2 Gene

  • Protein details for DCST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1A1-DCST2_HUMAN
    Recommended name:
    DC-STAMP domain-containing protein 2
    Protein Accession:
    Q5T1A1
    Secondary Accessions:
    • Q2M2R2
    • Q8N810
    • Q96M03

    Protein attributes for DCST2 Gene

    Size:
    773 amino acids
    Molecular mass:
    86230 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05065.1; Type=Frameshift; Positions=736; Evidence={ECO:0000305};

    Alternative splice isoforms for DCST2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCST2 Gene

Post-translational modifications for DCST2 Gene

  • Glycosylation at posLast=284284, isoforms=2296, and posLast=480480
  • Modification sites at PhosphoSitePlus

Other Protein References for DCST2 Gene

No data available for DME Specific Peptides for DCST2 Gene

Domains & Families for DCST2 Gene

Gene Families for DCST2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DCST2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DCST2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCST2: view

No data available for UniProtKB/Swiss-Prot for DCST2 Gene

Function for DCST2 Gene

Phenotypes From GWAS Catalog for DCST2 Gene

genes like me logo Genes that share phenotypes with DCST2: view

Animal Model Products

CRISPR Products

miRNA for DCST2 Gene

miRTarBase miRNAs that target DCST2

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCST2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCST2 Gene

Localization for DCST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCST2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCST2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for DCST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DCST2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCST2 Gene

Pathways & Interactions for DCST2 Gene

SuperPathways for DCST2 Gene

No Data Available

Interacting Proteins for DCST2 Gene

Gene Ontology (GO) - Biological Process for DCST2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCST2 Gene

Drugs & Compounds for DCST2 Gene

No Compound Related Data Available

Transcripts for DCST2 Gene

mRNA/cDNA for DCST2 Gene

Unigene Clusters for DCST2 Gene

DC-STAMP domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCST2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DCST2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - -

Relevant External Links for DCST2 Gene

GeneLoc Exon Structure for
DCST2
ECgene alternative splicing isoforms for
DCST2

Expression for DCST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCST2 Gene

mRNA differential expression in normal tissues according to GTEx for DCST2 Gene

This gene is overexpressed in Testis (x6.3), Skin - Not Sun Exposed (Suprapubic) (x4.7), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for DCST2 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCST2 Gene



Protein tissue co-expression partners for DCST2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCST2 Gene:

DCST2

SOURCE GeneReport for Unigene cluster for DCST2 Gene:

Hs.591491
genes like me logo Genes that share expression patterns with DCST2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCST2 Gene

Orthologs for DCST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCST2 33 34
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia DCST2 33 34
  • 85.45 (n)
dog
(Canis familiaris)
Mammalia DCST2 33 34
  • 84.39 (n)
rat
(Rattus norvegicus)
Mammalia Dcst2 33
  • 79.37 (n)
mouse
(Mus musculus)
Mammalia Dcst2 33 16
  • 77.17 (n)
oppossum
(Monodelphis domestica)
Mammalia DCST2 34
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCST2 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497585 33
  • 46.85 (n)
zebrafish
(Danio rerio)
Actinopterygii dcst2 33 34
  • 50.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6845 33 34
  • 41.45 (n)
CG32320 34
  • 18 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005412 33
  • 40.28 (n)
worm
(Caenorhabditis elegans)
Secernentea spe-42 33 34
  • 35.51 (n)
Species where no ortholog for DCST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCST2 Gene

ENSEMBL:
Gene Tree for DCST2 (if available)
TreeFam:
Gene Tree for DCST2 (if available)

Paralogs for DCST2 Gene

Paralogs for DCST2 Gene

genes like me logo Genes that share paralogs with DCST2: view

Variants for DCST2 Gene

Sequence variations from dbSNP and Humsavar for DCST2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000459606 -- 155,035,635(+) AAAAA(-/AG)AGGAA intron-variant, upstream-variant-2KB
rs1000511302 -- 155,035,229(+) TCAAT(-/CTCAG)CTCAC intron-variant, upstream-variant-2KB
rs1000911822 -- 155,023,330(+) CTACA(G/T)ACTCC intron-variant
rs1000962254 -- 155,022,745(+) GTTTC(-/AAACA)AAACA intron-variant
rs1001199649 -- 155,029,636(+) GCCCA(C/T)TCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCST2 Gene

Variant ID Type Subtype PubMed ID
esv2662939 CNV deletion 23128226
esv2676029 CNV deletion 23128226
esv2718396 CNV deletion 23290073
esv2718407 CNV deletion 23290073
esv3587614 CNV loss 21293372
nsv1127033 CNV deletion 24896259
nsv509502 CNV insertion 20534489
nsv952212 CNV deletion 24416366

Variation tolerance for DCST2 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCST2 Gene

Human Gene Mutation Database (HGMD)
DCST2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCST2 Gene

Disorders for DCST2 Gene

Relevant External Links for DCST2

Genetic Association Database (GAD)
DCST2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCST2

No disorders were found for DCST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCST2 Gene

Publications for DCST2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. A novel common variant in DCST2 is associated with length in early life and height in adulthood. (PMID: 25281659) van der Valk RJ … Early Growth Genetics (EGG) Consortium (Human molecular genetics 2015) 3 60
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3 60

Products for DCST2 Gene

Sources for DCST2 Gene

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