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Aliases for DCST2 Gene

Aliases for DCST2 Gene

  • DC-STAMP Domain Containing 2 2 3 5

External Ids for DCST2 Gene

Previous GeneCards Identifiers for DCST2 Gene

  • GC01M151805
  • GC01M153257
  • GC01M154990
  • GC01M126352

Summaries for DCST2 Gene

GeneCards Summary for DCST2 Gene

DCST2 (DC-STAMP Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is DCST1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCST2 Gene

Genomics for DCST2 Gene

Regulatory Elements for DCST2 Gene

Enhancers for DCST2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F155036 0.2 Ensembl 11.6 -3.1 -3120 1.0 HDGF LEF1 CREB3L1 ZIC2 ZNF121 ZFHX2 ZNF366 ZBTB48 PATZ1 ZNF600 DCST2 DCST1-AS1 FDPS DCST1 ADAM15
GH01F155022 1.1 Ensembl ENCODE 11.4 +10.9 10874 1.4 BMI1 RAD21 ZNF121 ZNF362 CEBPB ZEB2 REST SMARCA4 MYNN IKZF1 ZBTB7B ADAM15 DCST1-AS1 DCST2 FLAD1 PYGO2 UBE2Q1 CHRNB2
GH01F154998 1.1 FANTOM5 ENCODE 8.3 +29.3 29330 11.3 MLX CREB3L1 ZFP64 FEZF1 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 KIAA0907 THBS3 ENSG00000271267 RUSC1-AS1 ASH1L-AS1 MSTO2P KRTCAP2 ZBTB7B LOC101928120 EFNA4
GH01F155010 0.2 ENCODE 8 +21.5 21471 4.3 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 KIAA0907 ZBTB7B LOC101928120 FLAD1 ADAM15 DCST1-AS1 PYGO2 MIR92B EFNA4 ENSG00000251246
GH01F155015 1.1 Ensembl ENCODE 7.3 +15.9 15925 4.3 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 KIAA0907 ENSG00000271267 MSTO2P LOC101928120 PYGO2 THBS3 ASH1L-AS1 RUSC1-AS1 ADAM15 ZBTB7B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DCST2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCST2 Gene

Chromosome:
1
Start:
155,017,448 bp from pter
End:
155,033,781 bp from pter
Size:
16,334 bases
Orientation:
Minus strand

Genomic View for DCST2 Gene

Genes around DCST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCST2 Gene

Proteins for DCST2 Gene

  • Protein details for DCST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1A1-DCST2_HUMAN
    Recommended name:
    DC-STAMP domain-containing protein 2
    Protein Accession:
    Q5T1A1
    Secondary Accessions:
    • Q2M2R2
    • Q8N810
    • Q96M03

    Protein attributes for DCST2 Gene

    Size:
    773 amino acids
    Molecular mass:
    86230 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05065.1; Type=Frameshift; Positions=736; Evidence={ECO:0000305};

    Alternative splice isoforms for DCST2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCST2 Gene

Post-translational modifications for DCST2 Gene

  • Glycosylation at Asn 284, Asn 296, and Asn 480
  • Modification sites at PhosphoSitePlus

Other Protein References for DCST2 Gene

No data available for DME Specific Peptides for DCST2 Gene

Domains & Families for DCST2 Gene

Protein Domains for DCST2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DCST2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCST2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DCST2 Gene

Function for DCST2 Gene

genes like me logo Genes that share phenotypes with DCST2: view

Animal Model Products

miRNA for DCST2 Gene

miRTarBase miRNAs that target DCST2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCST2 Gene

Localization for DCST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCST2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCST2 Gene COMPARTMENTS Subcellular localization image for DCST2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for DCST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DCST2: view

Pathways & Interactions for DCST2 Gene

SuperPathways for DCST2 Gene

No Data Available

Interacting Proteins for DCST2 Gene

Gene Ontology (GO) - Biological Process for DCST2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCST2 Gene

Transcripts for DCST2 Gene

mRNA/cDNA for DCST2 Gene

Unigene Clusters for DCST2 Gene

DC-STAMP domain containing 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCST2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - -

Relevant External Links for DCST2 Gene

GeneLoc Exon Structure for
DCST2
ECgene alternative splicing isoforms for
DCST2

Expression for DCST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCST2 Gene

mRNA differential expression in normal tissues according to GTEx for DCST2 Gene

This gene is overexpressed in Testis (x6.3), Skin - Not Sun Exposed (Suprapubic) (x4.7), and Skin - Sun Exposed (Lower leg) (x4.1).

Protein differential expression in normal tissues from HIPED for DCST2 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCST2 Gene



Protein tissue co-expression partners for DCST2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCST2 Gene:

DCST2

SOURCE GeneReport for Unigene cluster for DCST2 Gene:

Hs.591491
genes like me logo Genes that share expression patterns with DCST2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DCST2 Gene

Orthologs for DCST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCST2 34 35
  • 99.31 (n)
cow
(Bos Taurus)
Mammalia DCST2 34 35
  • 85.45 (n)
dog
(Canis familiaris)
Mammalia DCST2 34 35
  • 84.39 (n)
rat
(Rattus norvegicus)
Mammalia Dcst2 34
  • 79.37 (n)
mouse
(Mus musculus)
Mammalia Dcst2 34 16
  • 77.17 (n)
oppossum
(Monodelphis domestica)
Mammalia DCST2 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCST2 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497585 34
  • 46.85 (n)
zebrafish
(Danio rerio)
Actinopterygii dcst2 34 35
  • 50.88 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6845 34 35
  • 41.45 (n)
CG32320 35
  • 18 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005412 34
  • 40.28 (n)
worm
(Caenorhabditis elegans)
Secernentea spe-42 34 35
  • 35.51 (n)
Species where no ortholog for DCST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCST2 Gene

ENSEMBL:
Gene Tree for DCST2 (if available)
TreeFam:
Gene Tree for DCST2 (if available)

Paralogs for DCST2 Gene

Paralogs for DCST2 Gene

genes like me logo Genes that share paralogs with DCST2: view

Variants for DCST2 Gene

Sequence variations from dbSNP and Humsavar for DCST2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10656868 -- 155,021,569(+) TTAAC(-/AAA/AAC/AACA)CCCCC intron-variant
rs10796936 -- 155,027,038(+) TTTTT(A/T)AATTT intron-variant
rs10908452 -- 155,029,453(+) CCAGA(C/T)CCCAG intron-variant
rs10908453 -- 155,033,615(+) GTAAA(A/G)CCTCC nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs111541777 -- 155,023,286(+) GGCCT(A/G)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCST2 Gene

Variant ID Type Subtype PubMed ID
esv2662939 CNV deletion 23128226
esv2676029 CNV deletion 23128226
esv2718396 CNV deletion 23290073
esv2718407 CNV deletion 23290073
esv3587614 CNV loss 21293372
nsv1127033 CNV deletion 24896259
nsv509502 CNV insertion 20534489
nsv952212 CNV deletion 24416366

Variation tolerance for DCST2 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCST2 Gene

Human Gene Mutation Database (HGMD)
DCST2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCST2 Gene

Disorders for DCST2 Gene

Relevant External Links for DCST2

Genetic Association Database (GAD)
DCST2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCST2

No disorders were found for DCST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCST2 Gene

Publications for DCST2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. A novel common variant in DCST2 is associated with length in early life and height in adulthood. (PMID: 25281659) van der Valk R.J. … Jaddoe V.W. (Hum. Mol. Genet. 2015) 3 64
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 64

Products for DCST2 Gene

Sources for DCST2 Gene

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