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Aliases for DCST2 Gene

Aliases for DCST2 Gene

  • DC-STAMP Domain Containing 2 2 3

External Ids for DCST2 Gene

Previous GeneCards Identifiers for DCST2 Gene

  • GC01M151805
  • GC01M153257
  • GC01M154990
  • GC01M126352

Summaries for DCST2 Gene

GeneCards Summary for DCST2 Gene

DCST2 (DC-STAMP Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is DCST1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCST2 Gene

Genomics for DCST2 Gene

Regulatory Elements for DCST2 Gene

Genomic Location for DCST2 Gene

Start:
155,017,446 bp from pter
End:
155,033,781 bp from pter
Size:
16,336 bases
Orientation:
Minus strand

Genomic View for DCST2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCST2 Gene

Proteins for DCST2 Gene

  • Protein details for DCST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1A1-DCST2_HUMAN
    Recommended name:
    DC-STAMP domain-containing protein 2
    Protein Accession:
    Q5T1A1
    Secondary Accessions:
    • Q2M2R2
    • Q8N810
    • Q96M03

    Protein attributes for DCST2 Gene

    Size:
    773 amino acids
    Molecular mass:
    86230 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05065.1; Type=Frameshift; Positions=736; Evidence={ECO:0000305};

    Alternative splice isoforms for DCST2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCST2 Gene

Proteomics data for DCST2 Gene at MOPED

Post-translational modifications for DCST2 Gene

  • Glycosylation at Asn284, Asn296, and Asn480
  • Modification sites at PhosphoSitePlus

Other Protein References for DCST2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCST2 Gene

Domains for DCST2 Gene

Protein Domains for DCST2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DCST2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCST2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DCST2 Gene

Function for DCST2 Gene

Phenotypes for DCST2 Gene

genes like me logo Genes that share phenotypes with DCST2: view

Animal Model Products

CRISPR Products

miRNA for DCST2 Gene

miRTarBase miRNAs that target DCST2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCST2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCST2 Gene

Localization for DCST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCST2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCST2 Gene COMPARTMENTS Subcellular localization image for DCST2 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for DCST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DCST2: view

Pathways for DCST2 Gene

SuperPathways for DCST2 Gene

No Data Available

Interacting Proteins for DCST2 Gene

Gene Ontology (GO) - Biological Process for DCST2 Gene

None

No data available for Pathways by source for DCST2 Gene

Transcripts for DCST2 Gene

mRNA/cDNA for DCST2 Gene

Unigene Clusters for DCST2 Gene

DC-STAMP domain containing 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCST2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DCST2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCST2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - -

Relevant External Links for DCST2 Gene

GeneLoc Exon Structure for
DCST2
ECgene alternative splicing isoforms for
DCST2

Expression for DCST2 Gene

mRNA expression in normal human tissues for DCST2 Gene

mRNA differential expression in normal tissues according to GTEx for DCST2 Gene

This gene is overexpressed in Testis (6.3), Skin - Not Sun Exposed (Suprapubic) (4.7), and Skin - Sun Exposed (Lower leg) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DCST2 Gene

SOURCE GeneReport for Unigene cluster for DCST2 Gene Hs.591491

genes like me logo Genes that share expressions with DCST2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DCST2 Gene

Orthologs for DCST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCST2 35
  • 99.31 (n)
  • 99.48 (a)
DCST2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCST2 35
  • 85.45 (n)
  • 83.64 (a)
DCST2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCST2 35
  • 84.39 (n)
  • 83.48 (a)
DCST2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcst2 35
  • 77.17 (n)
  • 73.38 (a)
Dcst2 16
oppossum
(Monodelphis domestica)
Mammalia DCST2 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcst2 35
  • 79.37 (n)
  • 77.67 (a)
lizard
(Anolis carolinensis)
Reptilia DCST2 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497585 35
  • 46.85 (n)
  • 33.6 (a)
zebrafish
(Danio rerio)
Actinopterygii dcst2 35
  • 50.88 (n)
  • 40.53 (a)
dcst2 36
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005412 35
  • 40.28 (n)
  • 28.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32320 36
  • 18 (a)
OneToMany
CG6845 35
  • 41.45 (n)
  • 28.53 (a)
CG6845 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spe-42 35
  • 35.51 (n)
  • 21.73 (a)
spe-42 36
  • 15 (a)
OneToOne
Species with no ortholog for DCST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCST2 Gene

ENSEMBL:
Gene Tree for DCST2 (if available)
TreeFam:
Gene Tree for DCST2 (if available)

Paralogs for DCST2 Gene

Paralogs for DCST2 Gene

genes like me logo Genes that share paralogs with DCST2: view

Variants for DCST2 Gene

Sequence variations from dbSNP and Humsavar for DCST2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2242193 -- 155,023,027(-) TGGAC(C/T)TTTGC intron-variant
rs4845403 -- 155,026,349(+) CAGCC(A/G)GCTGA reference, missense
rs4845701 -- 155,020,479(+) attct(C/T)ctgcc intron-variant
rs4845702 -- 155,020,609(+) tgatc(C/T)gcccg intron-variant
rs4845703 -- 155,020,899(+) CTCAC(C/T)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCST2 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872453 CNV Loss 21882294
nsv872454 CNV Loss 21882294
esv2676029 CNV Deletion 23128226
esv2718396 CNV Deletion 23290073
esv2718407 CNV Deletion 23290073
esv2662939 CNV Deletion 23128226
nsv872455 CNV Loss 21882294

Relevant External Links for DCST2 Gene

HapMap Linkage Disequilibrium report
DCST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCST2 Gene

Disorders for DCST2 Gene

Relevant External Links for DCST2

Genetic Association Database (GAD)
DCST2
genes like me logo Genes that share disorders with DCST2: view

No data available for UniProtKB/Swiss-Prot for DCST2 Gene

Publications for DCST2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. (PMID: 18952287) Jansen B.J. … Adema G.J. (Mol. Immunol. 2009) 3
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3

Products for DCST2 Gene

Sources for DCST2 Gene

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