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Aliases for DCST1 Gene

Aliases for DCST1 Gene

  • DC-STAMP Domain Containing 1 2 3

External Ids for DCST1 Gene

Summaries for DCST1 Gene

Entrez Gene Summary for DCST1 Gene

  • This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for DCST1 Gene

DCST1 (DC-STAMP Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is DCST2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCST1 Gene

Genomics for DCST1 Gene

Genomic Location for DCST1 Gene

Start:
155,033,806 bp from pter
End:
155,050,930 bp from pter
Size:
17,125 bases
Orientation:
Plus strand

Genomic View for DCST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCST1 Gene

Regulatory Elements for DCST1 Gene

Proteins for DCST1 Gene

  • Protein details for DCST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T197-DCST1_HUMAN
    Recommended name:
    DC-STAMP domain-containing protein 1
    Protein Accession:
    Q5T197
    Secondary Accessions:
    • B4DXA0
    • E9PHV3
    • Q5T198
    • Q6P1W6
    • Q71S70
    • Q96M70

    Protein attributes for DCST1 Gene

    Size:
    706 amino acids
    Molecular mass:
    80712 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCST1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCST1 Gene

Proteomics data for DCST1 Gene at MOPED

Post-translational modifications for DCST1 Gene

  • Glycosylation at Asn156, Asn189, Asn321, Asn349, and Asn525

Other Protein References for DCST1 Gene

No data available for DME Specific Peptides for DCST1 Gene

Domains for DCST1 Gene

Protein Domains for DCST1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

DCST1_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q5T197
genes like me logo Genes that share domains with DCST1: view

No data available for Gene Families for DCST1 Gene

Function for DCST1 Gene

Gene Ontology (GO) - Molecular Function for DCST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with DCST1: view

miRNA for DCST1 Gene

miRTarBase miRNAs that target DCST1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCST1 Gene

Localization for DCST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCST1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCST1 Gene COMPARTMENTS Subcellular localization image for DCST1 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DCST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DCST1: view

Pathways for DCST1 Gene

SuperPathways for DCST1 Gene

No Data Available

Interacting Proteins for DCST1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295542%0d%0a9606.ENSP00000451211%0d%0a
Selected Interacting proteins: ENSP00000295542 for DCST1 Gene via STRING

Symbol External ID(s) Details
NEDD1

Gene Ontology (GO) - Biological Process for DCST1 Gene

None

No data available for Pathways by source for DCST1 Gene

Transcripts for DCST1 Gene

Unigene Clusters for DCST1 Gene

DC-STAMP domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCST1 Gene

No ASD Table

Relevant External Links for DCST1 Gene

GeneLoc Exon Structure for
DCST1
ECgene alternative splicing isoforms for
DCST1

Expression for DCST1 Gene

mRNA expression in normal human tissues for DCST1 Gene

mRNA differential expression in normal tissues according to GTEx for DCST1 Gene

This gene is overexpressed in Testis (15.5), Skin - Sun Exposed (Lower leg) (5.4), and Skin - Not Sun Exposed (Suprapubic) (5.0).

SOURCE GeneReport for Unigene cluster for DCST1 Gene Hs.567717

genes like me logo Genes that share expressions with DCST1: view

Orthologs for DCST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCST1 36
  • 99.1 (n)
  • 98.73 (a)
DCST1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCST1 36
  • 85.59 (n)
  • 81.93 (a)
DCST1 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCST1 36
  • 82.93 (n)
  • 79.57 (a)
DCST1 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcst1 36
  • 78.06 (n)
  • 72.08 (a)
Dcst1 16
Dcst1 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCST1 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcst1 36
  • 79.17 (n)
  • 73.56 (a)
lizard
(Anolis carolinensis)
Reptilia DCST1 37
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734054 36
  • 48.48 (n)
  • 36.65 (a)
zebrafish
(Danio rerio)
Actinopterygii dcst1 36
  • 50.37 (n)
  • 42.56 (a)
dcst1 37
  • 40 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005349 36
  • 41.38 (n)
  • 27.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta snky 36
  • 40.48 (n)
  • 26.53 (a)
snky 37
  • 22 (a)
OneToOne
Species with no ortholog for DCST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCST1 Gene

ENSEMBL:
Gene Tree for DCST1 (if available)
TreeFam:
Gene Tree for DCST1 (if available)

Paralogs for DCST1 Gene

Paralogs for DCST1 Gene

genes like me logo Genes that share paralogs with DCST1: view

Variants for DCST1 Gene

Sequence variations from dbSNP and Humsavar for DCST1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4845406 -- 155,036,134(+) TCCCC(A/G)CAGTA intron-variant
rs4845704 -- 155,035,842(+) GGAGG(A/C)TTGCT intron-variant
rs6657129 -- 155,037,395(+) CCCAT(C/T)CCAAC intron-variant
rs7543463 -- 155,037,054(+) accaa(C/T)gcccC intron-variant
rs9427170 - 155,040,566(+) CAACA(C/T)CCGCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DCST1 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872454 CNV Loss 21882294
nsv872455 CNV Loss 21882294

Relevant External Links for DCST1 Gene

HapMap Linkage Disequilibrium report
DCST1
Human Gene Mutation Database (HGMD)
DCST1

Disorders for DCST1 Gene

Relevant External Links for DCST1

Genetic Association Database (GAD)
DCST1
genes like me logo Genes that share disorders with DCST1: view

No data available for UniProtKB/Swiss-Prot for DCST1 Gene

Publications for DCST1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  3. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  4. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for DCST1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DCST1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DCST1
    • Block miRNA regulation of DCST1 using miScript Target Protectors

    Sources for DCST1 Gene

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