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Aliases for DCST1 Gene

Aliases for DCST1 Gene

  • DC-STAMP Domain Containing 1 2 3 5

External Ids for DCST1 Gene

Previous GeneCards Identifiers for DCST1 Gene

  • GC01P151820
  • GC01P153272
  • GC01P126368

Summaries for DCST1 Gene

Entrez Gene Summary for DCST1 Gene

  • This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for DCST1 Gene

DCST1 (DC-STAMP Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is DCST2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCST1 Gene

Genomics for DCST1 Gene

Regulatory Elements for DCST1 Gene

Genomic Location for DCST1 Gene

Chromosome:
1
Start:
155,033,806 bp from pter
End:
155,050,930 bp from pter
Size:
17,125 bases
Orientation:
Plus strand

Genomic View for DCST1 Gene

Genes around DCST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCST1 Gene

Proteins for DCST1 Gene

  • Protein details for DCST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T197-DCST1_HUMAN
    Recommended name:
    DC-STAMP domain-containing protein 1
    Protein Accession:
    Q5T197
    Secondary Accessions:
    • B4DXA0
    • E9PHV3
    • Q5T198
    • Q6P1W6
    • Q71S70
    • Q96M70

    Protein attributes for DCST1 Gene

    Size:
    706 amino acids
    Molecular mass:
    80712 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCST1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCST1 Gene

Proteomics data for DCST1 Gene at MOPED

Post-translational modifications for DCST1 Gene

  • Glycosylation at Asn 156, Asn 189, Asn 321, Asn 349, and Asn 525
  • Modification sites at PhosphoSitePlus

Other Protein References for DCST1 Gene

No data available for DME Specific Peptides for DCST1 Gene

Domains & Families for DCST1 Gene

Protein Domains for DCST1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DCST1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T197

UniProtKB/Swiss-Prot:

DCST1_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with DCST1: view

No data available for Gene Families for DCST1 Gene

Function for DCST1 Gene

genes like me logo Genes that share phenotypes with DCST1: view

Animal Model Products

miRNA for DCST1 Gene

miRTarBase miRNAs that target DCST1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCST1 Gene

Localization for DCST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCST1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCST1 Gene COMPARTMENTS Subcellular localization image for DCST1 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for DCST1 Gene

Pathways & Interactions for DCST1 Gene

SuperPathways for DCST1 Gene

No Data Available

Interacting Proteins for DCST1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295542%0d%0a9606.ENSP00000451211%0d%0a
Selected Interacting proteins: ENSP00000295542 for DCST1 Gene via STRING

Symbol External ID(s) Details
NEDD1

Gene Ontology (GO) - Biological Process for DCST1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCST1 Gene

Drugs & Compounds for DCST1 Gene

No Compound Related Data Available

Transcripts for DCST1 Gene

Unigene Clusters for DCST1 Gene

DC-STAMP domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCST1 Gene

No ASD Table

Relevant External Links for DCST1 Gene

GeneLoc Exon Structure for
DCST1
ECgene alternative splicing isoforms for
DCST1

Expression for DCST1 Gene

mRNA expression in normal human tissues for DCST1 Gene

mRNA differential expression in normal tissues according to GTEx for DCST1 Gene

This gene is overexpressed in Testis (x15.5), Skin - Sun Exposed (Lower leg) (x5.4), and Skin - Not Sun Exposed (Suprapubic) (x5.0).

SOURCE GeneReport for Unigene cluster for DCST1 Gene Hs.567717

genes like me logo Genes that share expression patterns with DCST1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DCST1 Gene

Orthologs for DCST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCST1 35
  • 99.1 (n)
  • 98.73 (a)
DCST1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCST1 36
  • 82 (a)
OneToOne
DCST1 35
  • 85.59 (n)
  • 81.93 (a)
dog
(Canis familiaris)
Mammalia DCST1 35
  • 82.93 (n)
  • 79.57 (a)
DCST1 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcst1 16
Dcst1 36
  • 69 (a)
OneToOne
Dcst1 35
  • 78.06 (n)
  • 72.08 (a)
oppossum
(Monodelphis domestica)
Mammalia DCST1 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcst1 35
  • 79.17 (n)
  • 73.56 (a)
lizard
(Anolis carolinensis)
Reptilia DCST1 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734054 35
  • 48.48 (n)
  • 36.65 (a)
zebrafish
(Danio rerio)
Actinopterygii dcst1 35
  • 50.37 (n)
  • 42.56 (a)
dcst1 36
  • 40 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005349 35
  • 41.38 (n)
  • 27.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta snky 36
  • 22 (a)
OneToOne
snky 35
  • 40.48 (n)
  • 26.53 (a)
Species with no ortholog for DCST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCST1 Gene

ENSEMBL:
Gene Tree for DCST1 (if available)
TreeFam:
Gene Tree for DCST1 (if available)

Paralogs for DCST1 Gene

Paralogs for DCST1 Gene

genes like me logo Genes that share paralogs with DCST1: view

Variants for DCST1 Gene

Sequence variations from dbSNP and Humsavar for DCST1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_030868 -
rs9427170 - 155,040,566(+) CAACA(C/T)CCGCG reference, missense
rs7543463 -- 155,037,054(+) accaa(C/T)gcccC intron-variant
rs11264297 -- 155,036,497(+) ATCCC(C/T)TGCGC intron-variant
rs11264298 -- 155,036,782(+) TGCCC(A/G)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCST1 Gene

Variant ID Type Subtype PubMed ID
nsv509502 CNV Insertion 20534489
nsv872454 CNV Loss 21882294
nsv872455 CNV Loss 21882294

Variation tolerance for DCST1 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCST1 Gene

HapMap Linkage Disequilibrium report
DCST1
Human Gene Mutation Database (HGMD)
DCST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCST1 Gene

Disorders for DCST1 Gene

Relevant External Links for DCST1

Genetic Association Database (GAD)
DCST1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCST1

No disorders were found for DCST1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCST1 Gene

Publications for DCST1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DCST1 Gene

Sources for DCST1 Gene

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