DCST1 Gene
protein-coding GIFtS: 38
GCID: GC01P155006
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DC-STAMP domain containing 1
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Aliases
for DCST1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DC-STAMP Domain Containing 11 2 | | FLJ327851 | | DC-STAMP Domain-Containing Protein 12 |
Export aliases for DCST1 gene to outside databasesPrevious GC identifers: GC01P151820 GC01P153272 GC01P126368 |
Summaries
for DCST1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DCST1:
This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key rolein antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms havebeen found for this gene. (provided by RefSeq, Sep 2011)
|
Genomic Views
for DCST1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DCST1 gene promoter:
PPAR-gamma1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCST1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCST1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q22 Ensembl cytogenetic band: 1q22 HGNC cytogenetic band: 1q22DCST1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P155006: view genomic region
(about GC identifiers)
Start:
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155,006,300 bp from pter |
End:
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155,023,406 bp from pter |
Size:
|
17,107 bases |
Orientation:
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plus strand |
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Proteins
for DCST1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCST1_HUMAN, Q5T197 (See
protein sequence)Recommended Name: DC-STAMP domain-containing protein 1 Size: 706 amino acids; 80712 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B4DXA0 E9PHV3 Q5T198 Q6P1W6 Q71S70 Q96M70Alternative splicing: 3 isoforms: Q5T197-1 Q5T197-2 Q5T197-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DCST1: NX_Q5T197
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5T197
DCST1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001137159.1 NP_689707.2
ENSEMBL proteins: ENSP00000433667 ENSP00000295542 ENSP00000387369 ENSP00000357404 ENSP00000376271
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
DCST1 for ontologies About GeneDecksing
DCST1 Antibody Products:
Assay Products for DCST1: |
Protein
Domains /
Families
for DCST1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCST1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5T197ProtoNet protein and cluster: Q5T197 1 Blocks protein family: IPB012858 DC-STAMP-like
UniProtKB/Swiss-Prot: DCST1_HUMAN, Q5T197Similarity: Contains 1 RING-type zinc finger |
Function
for DCST1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCST1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCST1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DCST1 (NM_001143687) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCST1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCST1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCST1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
DCST1 for ontologies About GeneDecksing
|
Pathways & Interactions
for DCST1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCST1
|
Drugs & Compounds
for DCST1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCST1
Search CenterWatch for drugs/clinical trials and news about DCST1
|
Transcripts
for DCST1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCST1 gene (2 alternative transcripts): NM_001143687.2 NM_152494.3 Unigene Cluster for DCST1: DC-STAMP domain containing 1 Hs.567717 [show with all ESTs]Unigene Representative Sequence: NM_1524946 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000525273(uc010per.2) ENST00000295542(uc001fgn.2 uc010pes.2)
ENST00000423025 ENST00000368420 ENST00000368419 ENST00000392480
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCST1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCST1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DCST1 (NM_001143687) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCST1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCST1 |
Additional cDNA sequence: AK057347.1 AK301876.1 AK301902.1 AK301935.1 BC064844.1 6 DOTS entries: DT.95217362 DT.102843116 DT.97811146 DT.99972771 DT.100699345 DT.305855 24/380 AceView cDNA sequences (see all 380): AY560596 BU528501 AY560595 CA453985 BM824762 BG255588 CK300163 CA748879 BQ953491 CK903493 BQ775998 CF125928 BU527380 AA295191 BM790519 AY576417 AY560600 BQ688517 BI822503 BU739697 AY560597 BX360706 AL120796 BM818678
GeneLoc Exon Structure
|
Expression
for DCST1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCST1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCTGCCTGC
About this image
See DCST1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCST1
SOURCE GeneReport for Unigene cluster: Hs.567717
SABiosciences Expression via Pathway-Focused PCR Array including DCST1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCST1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCST1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCST1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCST1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCST1 |
Orthologs
for DCST1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DCST1 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
DCST16 |
-- |
47(a) |
1 ↔ 1 |
AAWZ02039400(317-8676) |
zebrafish
(Danio rerio) |
Actinopterygii |
dcst11 |
DC-STAMP domain containing 1 |
49.75(n)
41.32(a) |
|
556016 XM_678706.4 XP_683798.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
snky1 |
sneaky |
41.71(n)
27.01(a) |
|
39492 NM_140376.1 NP_648633.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
spe-426 |
defective SPErmatogenesis family member (spe-42) |
12(a) |
possible ortholog |
V(11733526-11736950) |
ENSEMBL Gene Tree for DCST1 (if available)
TreeFam Gene Tree for DCST1 (if available) |
Paralogs
for DCST1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DCST1 gene
- DCSTAMP2 DCST22
DCST1 for paralogs About GeneDecksing
|
Genomic Variants
for DCST1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCST1 (155006300 - 155023406 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DCST1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCST1 |
|
Disorders
/ Diseases
for DCST1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DCST1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCST1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DCST1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. (PubMed id 11169400)1 Hartgers F.C.... Adema G.J. (2000)
|
External Searches for DCST1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DCST1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCST1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCST1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCST1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCST1 gene:
Search GeneIP for patents involving DCST1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCST1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DCST1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCST1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCST1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DCST1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCST1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCST1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DCST1 | | OriGene Custom Protein Services for DCST1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCST1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCST1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCST1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCST1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCST1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCST1 |
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| | | | Search Tocris compounds for DCST1 |
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 | | | DCST1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCST1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DCST1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCST1 |
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