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Aliases for DCST1 Gene

Aliases for DCST1 Gene

  • DC-STAMP Domain Containing 1 2 3 5

External Ids for DCST1 Gene

Previous GeneCards Identifiers for DCST1 Gene

  • GC01P151820
  • GC01P153272
  • GC01P126368

Summaries for DCST1 Gene

Entrez Gene Summary for DCST1 Gene

  • This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for DCST1 Gene

DCST1 (DC-STAMP Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is DCST2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCST1 Gene

Genomics for DCST1 Gene

Regulatory Elements for DCST1 Gene

Enhancers for DCST1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F155856 1.5 FANTOM5 ENCODE 22.4 +825.1 825144 5.7 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 RRNAD1 KIAA0907 ENSG00000271267 MSTO2P THBS3 ASH1L-AS1 LOC101928120 PYGO2 KRTCAP2 DCST1
GH01F154998 1.6 FANTOM5 ENCODE 17.3 -29.4 -29355 11.3 MLX CREB3L1 ZFP64 FEZF1 YBX1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 KIAA0907 THBS3 ENSG00000271267 RUSC1-AS1 ASH1L-AS1 MSTO2P KRTCAP2 ZBTB7B LOC101928120 EFNA4
GH01F155242 1.2 ENCODE 22.4 +210.4 210437 2.9 CREB3L1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 MSTO2P RUSC1-AS1 THBS3 ASH1L PYGO2 LOC101928120 KRTCAP2 GBA
GH01F154489 1.6 FANTOM5 Ensembl ENCODE 13.1 -540.0 -540006 8.0 ATF1 PKNOX1 YY1 GATA2 ZNF548 FOS JUNB ZNF488 REST TBX21 SLC27A3 TDRD10 CHTOP KRTCAP2 SHE THBS3 DCST1 UBE2Q1-AS1 UBE2Q1 ENSG00000272030
GH01F154324 1.5 FANTOM5 ENCODE 13.1 -706.7 -706691 5.7 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 CHTOP LOC101928120 INTS3 THBS3 PYGO2 SLC27A3 RUSC1-AS1 DPM3 ENSG00000272654 ENSG00000238279
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCST1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCST1 Gene

155,033,806 bp from pter
155,050,930 bp from pter
17,125 bases
Plus strand

Genomic View for DCST1 Gene

Genes around DCST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCST1 Gene

Proteins for DCST1 Gene

  • Protein details for DCST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DC-STAMP domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B4DXA0
    • E9PHV3
    • Q5T198
    • Q6P1W6
    • Q71S70
    • Q96M70

    Protein attributes for DCST1 Gene

    706 amino acids
    Molecular mass:
    80712 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCST1 Gene


neXtProt entry for DCST1 Gene

Post-translational modifications for DCST1 Gene

  • Glycosylation at Asn 156, Asn 189, Asn 321, Asn 349, and Asn 525
  • Modification sites at PhosphoSitePlus

Other Protein References for DCST1 Gene

No data available for DME Specific Peptides for DCST1 Gene

Domains & Families for DCST1 Gene

Protein Domains for DCST1 Gene


Suggested Antigen Peptide Sequences for DCST1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RING-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with DCST1: view

No data available for Gene Families for DCST1 Gene

Function for DCST1 Gene

Gene Ontology (GO) - Molecular Function for DCST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DCST1: view
genes like me logo Genes that share phenotypes with DCST1: view

Animal Model Products

miRNA for DCST1 Gene

miRTarBase miRNAs that target DCST1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCST1 Gene

Localization for DCST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCST1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCST1 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DCST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DCST1: view

Pathways & Interactions for DCST1 Gene

SuperPathways for DCST1 Gene

No Data Available

Interacting Proteins for DCST1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000295542 Q5T197-DCST1_HUMAN for DCST1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for DCST1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCST1 Gene

Transcripts for DCST1 Gene

Unigene Clusters for DCST1 Gene

DC-STAMP domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCST1 Gene

No ASD Table

Relevant External Links for DCST1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCST1 Gene

mRNA differential expression in normal tissues according to GTEx for DCST1 Gene

This gene is overexpressed in Testis (x15.5), Skin - Sun Exposed (Lower leg) (x5.4), and Skin - Not Sun Exposed (Suprapubic) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of DCST1 Gene:


SOURCE GeneReport for Unigene cluster for DCST1 Gene:

genes like me logo Genes that share expression patterns with DCST1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DCST1 Gene

Orthologs for DCST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCST1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCST1 34 35
  • 99.1 (n)
(Bos Taurus)
Mammalia DCST1 34 35
  • 85.59 (n)
(Canis familiaris)
Mammalia DCST1 34 35
  • 82.93 (n)
(Rattus norvegicus)
Mammalia Dcst1 34
  • 79.17 (n)
(Mus musculus)
Mammalia Dcst1 34 16 35
  • 78.06 (n)
(Monodelphis domestica)
Mammalia DCST1 35
  • 61 (a)
(Anolis carolinensis)
Reptilia DCST1 35
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734054 34
  • 48.48 (n)
(Danio rerio)
Actinopterygii dcst1 34 35
  • 50.37 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005349 34
  • 41.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta snky 34 35
  • 40.48 (n)
Species where no ortholog for DCST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCST1 Gene

Gene Tree for DCST1 (if available)
Gene Tree for DCST1 (if available)

Paralogs for DCST1 Gene

Paralogs for DCST1 Gene

genes like me logo Genes that share paralogs with DCST1: view

Variants for DCST1 Gene

Sequence variations from dbSNP and Humsavar for DCST1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1048767 -- 155,045,445(-) GCATA(A/T)CTCCT intron-variant, nc-transcript-variant
rs10796937 -- 155,044,909(+) GATGG(A/T)GGGGG intron-variant
rs10908453 -- 155,033,615(+) GTAAA(A/G)CCTCC nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs111269217 -- 155,046,413(+) CTGTG(C/T)GGCTT intron-variant, reference, synonymous-codon
rs111298660 -- 155,048,434(+) GCCAG(G/T)ATTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCST1 Gene

Variant ID Type Subtype PubMed ID
nsv952212 CNV deletion 24416366
nsv509502 CNV insertion 20534489
nsv1133910 CNV deletion 24896259
esv3587615 CNV gain 21293372

Variation tolerance for DCST1 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCST1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCST1 Gene

Disorders for DCST1 Gene

Relevant External Links for DCST1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCST1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCST1 Gene

Publications for DCST1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3 64
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 64
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64

Products for DCST1 Gene

Sources for DCST1 Gene

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