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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCST1 Gene

protein-coding   GIFtS: 41
GCID: GC01P155006

DC-STAMP Domain Containing 1

  Search for DCST1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DC-STAMP Domain Containing 11 2
DC-STAMP Domain-Containing Protein 12

External Ids:    HGNC: 265391   Entrez Gene: 1490952   Ensembl: ENSG000001633577   UniProtKB: Q5T1973   

Export aliases for DCST1 gene to outside databases

Previous GC identifers: GC01P151820 GC01P153272 GC01P126368


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DCST1 Gene:
This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key
role in antigen processing and display for immune responses. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for DCST1 Gene: 
DCST1 (DC-STAMP domain containing 1) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is DCST2.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCST1 gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCST1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCST1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCST1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

DCST1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCST1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155006:  view genomic region     (about GC identifiers)

Start:
155,006,282 bp from pter      End:
155,023,406 bp from pter
Size:
17,125 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCST1_HUMAN, Q5T197 (See protein sequence)
Recommended Name: DC-STAMP domain-containing protein 1  
Size: 706 amino acids; 80712 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B4DXA0 E9PHV3 Q5T198 Q6P1W6 Q71S70 Q96M70
Alternative splicing: 3 isoforms:  Q5T197-1   Q5T197-2   Q5T197-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCST1: NX_Q5T197

Explore proteomics data for DCST1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5T197

  • DCST1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCST1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001137159.1  NP_689707.2  

    ENSEMBL proteins: 
     ENSP00000433667   ENSP00000295542   ENSP00000387369   ENSP00000357404   ENSP00000376271  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    DCST1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR012858 DC_STAMP-like

    Graphical View of Domain Structure for InterPro Entry Q5T197

    ProtoNet protein and cluster: Q5T197

    1 Blocks protein domain: IPB012858 DC-STAMP-like

    UniProtKB/Swiss-Prot: DCST1_HUMAN, Q5T197
    Similarity: Contains 1 RING-type zinc finger


    DCST1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    DCST1 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCST1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCST1

    Search CenterWatch for drugs/clinical trials and news about DCST1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCST1 gene (2 alternative transcripts): 
    NM_001143687.2  NM_152494.3  

    Unigene Cluster for DCST1:

    DC-STAMP domain containing 1
    Hs.567717  [show with all ESTs]
    Unigene Representative Sequence: NM_152494
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525273(uc010per.2) ENST00000295542(uc001fgn.2 uc010pes.2)
    ENST00000423025 ENST00000368420 ENST00000368419 ENST00000392480
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCST1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCST1

    Additional mRNA sequence: 

    AK057347.1 AK301876.1 AK301902.1 AK301935.1 BC064844.1 

    6 DOTS entries:

    DT.95217362  DT.102843116  DT.97811146  DT.99972771  DT.100699345  DT.305855 

    24/380 AceView cDNA sequences (see all 380):

    AI380702 BM681562 BQ922463 AY560596 BI754485 AW732352 BU739697 CA487716 
    CA748879 BM836603 BG679224 BG488647 BM971880 BU170531 BI823964 BU539532 
    BU528501 BX360706 BG766668 AY518542 CR614548 BC064844 BQ723768 AI660841 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCST1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGCCTGC
    DCST1 Expression
    About this image


    See DCST1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCST1

    SOURCE GeneReport for Unigene cluster: Hs.567717
        SABiosciences Expression via Pathway-Focused PCR Array including DCST1: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCST1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DCST1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcst11 , 5 DC-STAMP domain containing 11, 5 78.13(n)1
    72.18(a)1
      3 (39.08 cM)5
    777721  NM_029974.11  NP_084250.11 
     893502195 
    lizard
    (Anolis carolinensis)
    Reptilia DCST16
    DCST26
    Uncharacterized protein
    50(a)
    17(a)
    1 ↔ many
    1 ↔ many
    AAWZ02039400(317-7728)
    GL344009.1(101768-105773)
    zebrafish
    (Danio rerio)
    Actinopterygii dcst11 DC-STAMP domain containing 1 49.75(n)
    41.32(a)
      556016  XM_678706.4  XP_683798.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta snky1 sneaky 41.71(n)
    27.01(a)
      39492  NM_140376.1  NP_648633.1 


    ENSEMBL Gene Tree for DCST1 (if available)
    TreeFam Gene Tree for DCST1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCST1 gene
    DCST22  

    DCST1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/519 SNPs in DCST1 are shown (see all 519)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454536401,2
    Cuntested1161520354(+) AGATCA/GATGAC 4 N D mis10--------
    rs1475573521,2
    C--126369520(+) ATTAA-/ATTC  
            
    ATTCA
    2 -- int10--------
    rs343905011,2
    C--126369522(+) ATTCA-/ATT   
      C
    /TTCA
    CTCAG
    2 -- int10--------
    rs351141461,2
    C--126371520(+) CCACC-/AACGCC 2 -- int13Minor allele frequency- A:0.17NA CSA 6
    rs75434631,2
    C,F,A,H--155009530(+) accaaC/TgcccC 2 -- int16Minor allele frequency- T:0.02NS NA 666
    rs3695630541,2
    C--155016956(+) TCTCA-/AAAAAAA 2 -- int10--------
    rs1463816261,2
    --161506330(+) GGTACA/GGGTGA 2 -- us2k10--------
    rs1829466761,2
    C--161506446(+) CTCATG/TGCAAC 2 -- us2k10--------
    rs1858343221,2
    --161506597(+) ATCTCC/TTGACC 2 -- us2k10--------
    rs1397596031,2
    --161506615(+) CCACCA/GCCTCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DCST1 (155006282 - 155023406 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DCST1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509502CNV Insertion20534489
    nsv872455CNV Loss21882294
    nsv872454CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DCST1 for disorders           About MalaCards

    DCST1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DCST1

    Export disorders for DCST1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCST1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DCST1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    3. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. (PubMed id 11169400)1 Hartgers F.C.... Adema G.J. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 149095 HGNC: 26539 AceView: ADAM15andFLJ32785 Ensembl:ENSG00000163357 euGenes: HUgn149095
    ECgene: DCST1 H-InvDB: DCST1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCST1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCST1 gene:
    Search GeneIP for patents involving DCST1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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