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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCPS Gene

protein-coding   GIFtS: 58
GCID: GC11P126173

Decapping Enzyme, Scavenger

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Decapping Enzyme, Scavenger1 2     HINT-52 3
Decapping Scavenger Enzyme2 3     HINT52 3
Hint-Related 7meGMP-Directed Hydrolase2 3     HSL12
Histidine Triad Nucleotide-Binding Protein 52 3     Heat Shock-Like Protein 12
Histidine Triad Protein Member 52 3     Homolog Of C. Elegans 7meGMP-Directed Hydrolase Dcs-12
Scavenger MRNA-Decapping Enzyme DcpS2 3     M7GpppX Diphosphatase2
DCS-12 3     MRNA Decapping Enzyme2
DCS12 3     EC 3.6.1.593

External Ids:    HGNC: 298121   Entrez Gene: 289602   Ensembl: ENSG000001100637   OMIM: 6105345   UniProtKB: Q96C863   

Export aliases for DCPS gene to outside databases

Previous GC identifers: GC11P128174 GC11P127686 GC11P126207 GC11P125711 GC11P125678 GC11P122121


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DCPS Gene: 
DCPS (decapping enzyme, scavenger) is a protein-coding gene. Diseases associated with DCPS include spinal muscular atrophy, and vaginitis, and among its related super-pathways are RNA degradation and Metabolism of RNA. GO annotations related to this gene include RNA 7-methylguanosine cap binding and m7G(5')pppN diphosphatase activity.

UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
Function: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the
degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like
7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped
oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine
monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate
(m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no
decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze
7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay
pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also
converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first
intron splicing of pre-mRNAs. Inhibits activation-induced cell death

Gene Wiki entry for DCPS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCPS gene promoter:
         USF1   HNF-3beta   Tal-1beta   GATA-1   GATA-2   E47   AREB6   USF-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCPS promoter sequence
   Search SABiosciences Chromatin IP Primers for DCPS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24

DCPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCPS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P126173:  view genomic region     (about GC identifiers)

Start:
126,173,647 bp from pter      End:
126,215,644 bp from pter
Size:
41,998 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86 (See protein sequence)
Recommended Name: m7GpppX diphosphatase  
Size: 337 amino acids; 38609 Da
Subunit: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and
EXOSC4. Interacts with NDOR1
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling
protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner
6/7 PDB 3D structures from and Proteopedia for DCPS (see all 7):
1ST0 (3D)        1ST4 (3D)        1XML (3D)        1XMM (3D)        3BL7 (3D)        3BL9 (3D)    
Secondary accessions: Q8NHL8 Q9Y2S5

Explore the universe of human proteins at neXtProt for DCPS: NX_Q96C86

Explore proteomics data for DCPS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96C86

  • DCPS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCPS Protein Expression
    REFSEQ proteins: NP_054745.1  
    ENSEMBL proteins: 
     ENSP00000263579  
    Reactome Protein details: Q96C86
    Human Recombinant Protein Products for DCPS: 
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    Novus Biologicals DCPS Lysate
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    ProSpec Recombinant Protein for DCPS
    Cloud-Clone Corp. Proteins for DCPS 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA18441014
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--

    DCPS for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for DCPS 
    Cloud-Clone Corp. CLIAs for DCPS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR008594 DcpS/DCS2
     IPR019808 Histidine_triad_CS
     IPR011146 HIT-like
     IPR011145 Scavenger_mRNA_decap_enz_N

    Graphical View of Domain Structure for InterPro Entry Q96C86

    ProtoNet protein and cluster: Q96C86

    1 Blocks protein domain: IPB001310 Histidine triad (HIT) protein

    UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
    Domain: The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping
    activity. The N-terminus is necessary but not sufficient for binding cap structures
    Similarity: Belongs to the HIT family


    DCPS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCPS_HUMAN, Q96C86
    Function: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the
    degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like
    7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped
    oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine
    monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate
    (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no
    decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze
    7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay
    pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also
    converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first
    intron splicing of pre-mRNAs. Inhibits activation-induced cell death
    Catalytic activity: A 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) + H(2)O = N(7)-methylguanosine 5'-phosphate +
    a 5'-diphospho-(mRNA)
    Enzyme regulation: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping
    scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline
    Induction: Up-regulated by menadione. Up-regulated by the transcription factor LTF isoform delta-lactoferrin (at
    protein level)

         Enzyme Number (IUBMB): EC 3.6.1.591

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000340RNA 7-methylguanosine cap binding IDA12198172
    GO:0003824catalytic activity ----
    GO:0005515protein binding IPI16140270
    GO:0016787hydrolase activity ----
    GO:0050072m7G(5')pppN diphosphatase activity IDA12198172
         
    DCPS for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dcps):
     no phenotypic analysis 

    DCPS for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DCPS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DCPS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCPS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCPS 

    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCPS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DCPS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    RNA degradation0.49
    2Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    3Destabilization of mRNA by Tristetraprolin (TTP)
    mRNA Decay by 3' to 5' Exoribonuclease0.56
    4Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5        Reactome Pathways for DCPS
        Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression
    mRNA Decay by 3' to 5' Exoribonuclease


    1         Kegg Pathway  (Kegg details for DCPS):
        RNA degradation


    DCPS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for DCPS (Q96C863 ENSP000002635794) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2FP612183, ENSP000004038524I2D: score=5 STRING: ENSP00000403852
    FEN1P397483, ENSP000003054804I2D: score=1 STRING: ENSP00000305480
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    TREHO432803, ENSP000002640294I2D: score=1 STRING: ENSP00000264029
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS12198172
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IEA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    DCPS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DCPS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCPS

    7 DrugBank Compounds for DCPS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    7-Methyl-Gpppa-- --target--17139284 17016423
    7n-Methyl-8-Hydroguanosine-5'-Diphosphate-- --target--17139284 17016423
    Mrna Cap Analog N7-Methyl Gpppg-- --target--17139284 17016423
    N7-Methyl-Guanosine-5'-Monophosphate-- --target--17139284 17016423
    5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine-- --target--10592235
    5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine-- --target--10592235
    5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine-- --target--10592235

    2 Novoseek inferred chemical compound relationships for DCPS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavin 64.4 2 16140270 (1), 12871939 (1)
    nadph 41.6 1 12871939 (1)

    Search CenterWatch for drugs/clinical trials and news about DCPS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCPS gene: 
    NM_014026.3  

    Unigene Cluster for DCPS:

    Decapping enzyme, scavenger
    Hs.504249  [show with all ESTs]
    Unigene Representative Sequence: AK090828
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263579(uc001qdp.3) ENST00000530860 ENST00000529149
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCPS

    Additional mRNA sequence: 

    AF077201.1 AF532613.1 AK026554.1 AK090828.1 AK223089.1 AK307403.1 AY040771.1 AY077684.1 
    BC014532.1 

    9 DOTS entries:

    DT.416250  DT.40305809  DT.100737676  DT.95080899  DT.95080903  DT.95080901  DT.95080926  DT.100728418 
    DT.91657226 

    24/151 AceView cDNA sequences (see all 151):

    AK090828 CR606807 BX375089 BP428507 BQ023313 AI827832 NM_014026 BU726067 
    CR607221 CB161771 CB155926 CR616240 BM794099 AI674638 AY077684 CB161608 
    BE382749 AF532613 AA581897 AA233083 BE266494 AI862696 AI377903 BU178288 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DCPS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                    -     -                 -                           
    SP2:                                            -                           
    SP3:                                            -     -                     
    SP4:                    -     -     -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for DCPS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCPS expression in normal human tissues (normalized intensities)      DCPS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTTCAC
    DCPS Expression
    About this image


    DCPS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 5 entries
             colon ; peripheral nerve/ganglion   
             autonomic/sympathetic/ganglion   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See DCPS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCPS

    SOURCE GeneReport for Unigene cluster: Hs.504249

    UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
    Tissue specificity: Detected in liver, brain, kidney, testis and prostate

        SABiosciences Custom PCR Arrays for DCPS
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCPS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DCPS gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcps1 , 5 decapping enzyme, scavenger1, 5 86.37(n)1
    90.15(a)1
      9 (19.71 cM)5
    693051  NM_027030.21  NP_081306.11 
     351244085 
    chicken
    (Gallus gallus)
    Aves DCPS1 decapping enzyme, scavenger 68.18(n)
    64.72(a)
      419716  XM_417859.3  XP_417859.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCPS6
    Uncharacterized protein
    69(a)
    1 ↔ 1
    GL343322.1(1129449-1158460)
    African clawed frog
    (Xenopus laevis)
    Amphibia hint5-A2 histidine triad protein member 5 71.42(n)    AY040776.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF510720.12   -- 73.79(n)    AF510720.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG20911 CG2091 53.68(n)
    44.56(a)
      40711  NM_141325.2  NP_649582.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dcs-11 Protein DCS-1 51.35(n)
    42.08(a)
      180315  NM_075475.2  NP_507876.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCS2(YOR173W)4 Non-essential, stress induced regulatory protein; modulates more   --   15(657264-658325) 854344  NP_014816.2 


    ENSEMBL Gene Tree for DCPS (if available)
    TreeFam Gene Tree for DCPS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/841 SNPs in DCPS are shown (see all 841)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440400241,2
    --126171723(+) TTTACC/TTCATG 1 -- us2k10--------
    rs1464362131,2
    C--126171725(+) TACCTC/TATGTA 1 -- us2k10--------
    rs1868877171,2
    --126171872(+) GGCCCC/GACTTC 1 -- us2k10--------
    rs1925339711,2
    --126171902(+) TCTTTC/TTGTTA 1 -- us2k10--------
    rs112204491,2
    C--126171932(+) gggtgC/Tggtgg 1 -- us2k10--------
    rs1839280451,2
    --126171955(+) ATGCCA/TGCTCT 1 -- us2k10--------
    rs1435106501,2
    --126171994(+) GGTCAA/GGAGTT 1 -- us2k10--------
    rs1890193611,2
    --126172036(+) TGACTC/GTACTA 1 -- us2k10--------
    rs285893461,2
    C,F--126172159(+) GATCGC/TGCCAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1929971631,2
    --126172198(+) AGTCTC/TTCCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DCPS (126173647 - 126215644 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DCPS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663692CNV Deletion23128226

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DCPS
    DNA2.0 Custom Variant and Variant Library Synthesis for DCPS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610534    OMIM disorders: --

    4 diseases for DCPS:    About MalaCards
    spinal muscular atrophy    vaginitis    muscular atrophy    prostatitis


    DCPS for disorders           About GeneDecksing


    Export disorders for DCPS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCPS gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with DCPS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. (PubMed id 14523240)1, 2, 3 van Dijk E....Seraphin B. (2003)
    2. The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. (PubMed id 12198172)1, 2, 3 Liu H.... Kiledjian M. (2002)
    3. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PubMed id 12871939)1, 2, 9 Kwasnicka D.A.... Vincent S.R. (2003)
    4. Functional analysis of mRNA scavenger decapping enzymes. (PubMed id 15273322)1, 2, 9 Liu S.-W.... Kiledjian M. (2004)
    5. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PubMed id 16140270)1, 2, 9 Kwasnicka-Crawford D.A. and Vincent S.R. (2005)
    6. Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. (PubMed id 15068804)1, 2, 9 Gu M.... Lima C.D. (2004)
    7. Proteomic approach to the identification of novel delta-lactoferrin target genes: Characterization of DcpS, an mRNA scavenger decapping enzyme. (PubMed id 18725266)1, 2 Mariller C....Pierce A. (2009)
    8. DcpS as a therapeutic target for spinal muscular atrophy. (PubMed id 18839960)1, 2 Singh J.... Gurney M.E. (2008)
    9. DcpS scavenger decapping enzyme can modulate pre-mRNA splicing. (PubMed id 18426921)1, 2 Shen V....Kiledjian M. (2008)
    10. Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping. (PubMed id 15769464)1, 2 Chen N....Song H. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28960 HGNC: 29812 AceView: DCPS Ensembl:ENSG00000110063 euGenes: HUgn28960
    ECgene: DCPS Kegg: 28960 H-InvDB: DCPS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCPS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCPS gene:
    Search GeneIP for patents involving DCPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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