 |
 | Services
| |
 |
Aliases & Descriptions for DCPS
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DCS-1 3 | | DCS1 3 | | EC 3.-.-.- 3 | | HINT-5 1, 2, 3 | | HINT5 3 | | HSL1 1, 2 | | HSPC015 1, 2 |
| | | Descriptions |
|---|
| Hint-related 7meGMP-directed hydrolase 3 | | Histidine triad protein member 5 2, 3 | | decapping enzyme, scavenger 2 | | heat shock-like protein 1 2 | | homolog of C. elegans 7meGMP-directed hydrolase dcs-1 2 | | mRNA decapping enzyme 2 |
|
| | Search outside databases for aliases for DCPS genePrevious GC identifers: GC11P128174 GC11P127686 GC11P126207 GC11P125711 |
Summaries for DCPS(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86Function: Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotidesGene Wiki entry for DCPS |
Genomic Location for DCPS
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the DCPS gene 
Entrez Gene cytogenetic band: 11q24.2 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q24DCPS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P125678:
(about GC identifiers)
Start:
|
125,678,857 bp from pter |
End:
|
125,720,854 bp from pter |
Size:
|
41,998 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033899.7
| Proteins for DCPS
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86 (See
protein sequence)Recommended Name: Scavenger mRNA-decapping enzyme DcpS Size: 337 amino acids; 38609 Da
Subunit: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4
Subcellular location: Cytoplasm. Nucleus
PDB structures from and Proteopedia :1ST0 (3D)
 1ST4 (3D)
 1XML (3D)
 1XMM (3D)
 3BL7 (3D)
 3BL9 (3D)
 3BLA (3D)
 
Secondary accessions: Q8NHL8 Q9Y2S5Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_054745.1
ENSEMBL proteins: ENSP00000263579
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: DCPS 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for DCPS: Assays for DCPS: | Protein
Domains/ Families for DCPS(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96C86
ProtoNet protein and cluster: Q96C86 1 Blocks protein family: IPB001310 Histidine triad (HIT) protein
UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86Similarity: Belongs to the HIT family | Gene Function for DCPS
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014026
Applied Biosystems Silencer® siRNAs for DCPS
Sigma-Aldrich siRNA for DCPS  Sigma-Aldrich shRNA for DCPS  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014026                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014026                                  untagged cDNA clone in CMV expression vector: NM_014026 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014026
UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86Function: Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotidesEnzyme Number (IUBMB): EC 3.-.-.- 2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for DCPS
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/21 Interacting proteins for DCPS (ENSP000002635793) via UniProtKB, MINT, and/or STRING (see all 21
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
IEA | -- | | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA |
IEA | -- | About this table
|
Drugs & Compounds for DCPS(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for DCPS 2 Novoseek chemical compound relationships for DCPS gene
About this table
|
Transcripts for DCPS(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014026
Sigma-Aldrich siRNA for DCPS  Sigma-Aldrich shRNA for DCPS  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014026 REFSEQ mRNAs for DCPS gene: NM_014026.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014026               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014026                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014026                                  untagged cDNA clone in CMV expression vector: NM_014026  Additional cDNA sequence: AF077201.1 AF532613.1 AK026554.1 AK090828.1 AK223089.1 AK307403.1 AY040771.1 AY077684.1 BC014532.1 CR606807.1 CR607221.1 CR616240.1 9 DOTS entries: DT.416250 DT.40305809 DT.100737676 DT.95080899 DT.95080903 DT.100728418 DT.95080901 DT.95080926 DT.91657226 24/151 AceView cDNA sequences (see all 151
):AI674638 CR607221 CR616240 AA581897 AY077684 CB161608 BM794099 CB161771 CR606807 BU726067 BX375089 AI827832 BE382749 BP428507 CB155926 NM_014026 AF532613 AK090828 AA233083 BQ023313 BG480083 CB126772 CA424841 AA314357
highest scoring ESTs for DCPS:AI827832 AA233083 AA243639 AA243679 AA243865 AA324991 AA455059 AA455098 AA455954 AA491001 Unigene Cluster for DCPS: Decapping enzyme, scavenger Hs.504249 [show with all ESTs]Unigene Representative Sequence: AK090828
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DCPS
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for DCPS
1 Ensembl transcript including schematic representation: ENST00000263579
|
Expression for DCPS
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DCPS expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DCPS
1 / 2 / 3 3 probe-sets matching DCPS gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGCACTTCAC
SOURCE GeneReport for Unigene cluster: Hs.504249 UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86Tissue specificity: Detected in liver, brain, kidney, testis and prostate |
Orthologs for DCPS
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DCPS gene from 5/17 species (see all 17
)
About this table Species with no ortholog for DCPS
ENSEMBL Gene Tree for DCPS | Paralogs for DCPS(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for DCPS(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for DCPS (up to first 250kb)
|
Disorders & Mutations for DCPS
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610534
|
Medical News for DCPS(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for DCPS (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/19 PubMed articles for DCPS gene (see all 19
):- DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. (PubMed id 14523240)2, 3, 4 van Dijk E....Seraphin B. (2003)
- The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. (PubMed id 12198172)2, 3, 4 Liu H.... Kiledjian M. (2002)
- Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PubMed id 12871939)1, 3, 4 Kwasnicka D.A.... Vincent S.R. (2003)
- Functional analysis of mRNA scavenger decapping enzymes. (PubMed id 15273322)1, 3, 4 Liu S.-W.... Kiledjian M. (2004)
- Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. (PubMed id 15068804)1, 3, 4 Gu M.... Lima C.D. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Functional link between the mammalian exosome and mRNA decapping. (PubMed id 11747811)3, 4 Wang Z. and Kiledjian M. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)3, 4 Zhang Q.H....Chen Z. (2000)
- Mechanistic and kinetic analysis of the DcpS scavenger decapping enzyme. (PubMed id 18441014)1, 3 Liu S.W....Kiledjian M. (2008)
- Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PubMed id 16140270)1, 3 Kwasnicka-Crawford D.A. and Vincent S.R. (2005)
|
Search for DCPS
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DCPS
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DCPS
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCPS(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for DCPS(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for DCPS:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins (DCPS) | | Antibodies (DCPS) |
| | | Search Tocris compounds for DCPS |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|