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DCPS Gene

protein-coding   GIFtS: 59
GCID: GC11P126173

Decapping Enzyme, Scavenger

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Decapping Enzyme, Scavenger1 2     DCS-12 3
DCS12 3 5     HINT-52 3
HINT52 3 5     HSL12
Decapping Scavenger Enzyme2 3     Heat Shock-Like Protein 12
Hint-Related 7meGMP-Directed Hydrolase2 3     Homolog Of C. Elegans 7meGMP-Directed Hydrolase Dcs-12
Histidine Triad Nucleotide-Binding Protein 52 3     M7GpppX Diphosphatase2
Histidine Triad Protein Member 52 3     MRNA Decapping Enzyme2
Scavenger MRNA-Decapping Enzyme DcpS2 3     EC 3.6.1.593

External Ids:    HGNC: 298121   Entrez Gene: 289602   Ensembl: ENSG000001100637   OMIM: 6105345   UniProtKB: Q96C863   

Export aliases for DCPS gene to outside databases

Previous GC identifers: GC11P128174 GC11P127686 GC11P126207 GC11P125711 GC11P125678 GC11P122121


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DCPS Gene:
DCPS (decapping enzyme, scavenger) is a protein-coding gene. Diseases associated with DCPS include spinal muscular atrophy, and vaginitis. GO annotations related to this gene include RNA 7-methylguanosine cap binding and m7G(5')pppN diphosphatase activity.

UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
Function: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the
degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like
7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped
oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine
monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate
(m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no
decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze
7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay
pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also
converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first
intron splicing of pre-mRNAs. Inhibits activation-induced cell death

Gene Wiki entry for DCPS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCPS gene promoter:
         USF1   HNF-3beta   Tal-1beta   GATA-1   GATA-2   E47   AREB6   USF-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCPS promoter sequence
   Search Chromatin IP Primers for DCPS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24

DCPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCPS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P126173:  view genomic region     (about GC identifiers)

Start:
126,173,647 bp from pter      End:
126,215,644 bp from pter
Size:
41,998 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86 (See protein sequence)
Recommended Name: m7GpppX diphosphatase  
Size: 337 amino acids; 38609 Da
Subunit: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and
EXOSC4. Interacts with NDOR1
Selected PDB 3D structures from and Proteopedia for DCPS (see all 7):
1ST0 (3D)        1ST4 (3D)        1XML (3D)        1XMM (3D)        3BL7 (3D)        3BL9 (3D)    
Secondary accessions: Q8NHL8 Q9Y2S5

Explore the universe of human proteins at neXtProt for DCPS: NX_Q96C86

Explore proteomics data for DCPS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys128, Lys138
  • Modification sites at PhosphoSitePlus

  • See DCPS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054745.1  
    ENSEMBL proteins: 
     ENSP00000263579  
    Reactome Protein details: Q96C86

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    Cloud-Clone Corp. CLIAs for DCPS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR008594 DcpS/DCS2
     IPR019808 Histidine_triad_CS
     IPR011146 HIT-like
     IPR011145 Scavenger_mRNA_decap_enz_N

    Graphical View of Domain Structure for InterPro Entry Q96C86

    ProtoNet protein and cluster: Q96C86

    1 Blocks protein domain: IPB001310 Histidine triad (HIT) protein

    UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
    Domain: The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping
    activity. The N-terminus is necessary but not sufficient for binding cap structures
    Similarity: Belongs to the HIT family


    DCPS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCPS_HUMAN, Q96C86
    Function: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the
    degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like
    7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped
    oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine
    monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate
    (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no
    decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze
    7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay
    pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also
    converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP. Plays a role in first
    intron splicing of pre-mRNAs. Inhibits activation-induced cell death
    Catalytic activity: A 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) + H(2)O = N(7)-methylguanosine 5'-phosphate +
    a 5'-diphospho-(mRNA)
    Enzyme regulation: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping
    scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline
    Induction: Up-regulated by menadione. Up-regulated by the transcription factor LTF isoform delta-lactoferrin (at
    protein level)

         Enzyme Number (IUBMB): EC 3.6.1.591

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000340RNA 7-methylguanosine cap binding IDA12198172
    GO:0003824catalytic activity ----
    GO:0005515protein binding IPI16140270
    GO:0016787hydrolase activity ----
    GO:0050072m7G(5')pppN diphosphatase activity IDA12198172
         
    DCPS for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dcps):
     no phenotypic analysis 

    DCPS for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCPS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCPS

    miRNA
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    hsa-mir-193b-3p (MIRT041500)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCPS_HUMAN, Q96C86: Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling
    protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA18441014
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--

    DCPS for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCPS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 3 to 5' Exoribonuclease0.00
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for DCPS
        mRNA decay by 3' to 5' exoribonuclease


    1 Kegg Pathway  (Kegg details for DCPS):
        RNA degradation


    DCPS for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCPS
    Interactions:

        Search GeneGlobe Interaction Network for DCPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCPS (Q96C863 ENSP000002635794) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TREHO432803, ENSP000002640294I2D: score=1 STRING: ENSP00000264029
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CCNHP519463, ENSP000002568974I2D: score=4 STRING: ENSP00000256897
    ABCF2Q9UG633, ENSP000002223884I2D: score=1 STRING: ENSP00000222388
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS12198172
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IEA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    DCPS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCPS

    7 DrugBank Compounds for DCPS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    7-Methyl-Gpppa-- --target--17139284 17016423
    7n-Methyl-8-Hydroguanosine-5'-Diphosphate-- --target--17139284 17016423
    Mrna Cap Analog N7-Methyl Gpppg-- --target--17139284 17016423
    N7-Methyl-Guanosine-5'-Monophosphate-- --target--17139284 17016423
    5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine-- --target--10592235
    5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine-- --target--10592235
    5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine-- --target--10592235

    2 Novoseek inferred chemical compound relationships for DCPS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavin 64.4 2 16140270 (1), 12871939 (1)
    nadph 41.6 1 12871939 (1)



    DCPS for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCPS gene: 
    NM_014026.3  

    Unigene Cluster for DCPS:

    Decapping enzyme, scavenger
    Hs.504249  [show with all ESTs]
    Unigene Representative Sequence: AK090828
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263579(uc001qdp.3) ENST00000530860 ENST00000529149
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat DCPS

    Additional mRNA sequence: 

    AF077201.1 AF532613.1 AK026554.1 AK090828.1 AK223089.1 AK307403.1 AY040771.1 AY077684.1 
    BC014532.1 

    9 DOTS entries:

    DT.416250  DT.40305809  DT.100737676  DT.95080899  DT.95080903  DT.95080901  DT.95080926  DT.100728418 
    DT.91657226 

    Selected AceView cDNA sequences (see all 151):

    CR606807 BP428507 AI827832 BM794099 CB161608 CB161771 AK090828 BU726067 
    AF532613 CR616240 BX375089 AA233083 AY077684 CB155926 AI674638 NM_014026 
    BE382749 BQ023313 AA581897 CR607221 AW673637 BU848681 BF685610 AI862696 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DCPS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                    -     -                 -                           
    SP2:                                            -                           
    SP3:                                            -     -                     
    SP4:                    -     -     -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for DCPS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCPS expression in normal human tissues (normalized intensities)      DCPS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTTCAC
    DCPS Expression
    About this image


    DCPS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    DCPS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCPS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504249

    UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
    Tissue specificity: Detected in liver, brain, kidney, testis and prostate

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    QuantiFast Probe-based Assays in human, mouse, rat DCPS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCPS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DCPS gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcps1 , 5 decapping enzyme, scavenger1, 5 86.37(n)1
    90.15(a)1
      9 (19.71 cM)5
    693051  NM_027030.21  NP_081306.11 
     351244085 
    chicken
    (Gallus gallus)
    Aves DCPS1 decapping enzyme, scavenger 68.18(n)
    64.72(a)
      419716  XM_417859.4  XP_417859.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCPS6
    decapping enzyme, scavenger
    69(a)
    1 ↔ 1
    GL343322.1(1129449-1158460)
    African clawed frog
    (Xenopus laevis)
    Amphibia hint5-A2 histidine triad protein member 5 71.42(n)    AY040776.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF510720.12   -- 73.79(n)    AF510720.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG20911 CG2091 53.73(n)
    44.41(a)
      40711  NM_141325.3  NP_649582.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dcs-11 dcs-1 51.35(n)
    42.08(a)
      180315  NM_001269968.1  NP_001256897.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCS2(YOR173W)4 Non-essential, stress induced regulatory protein; modulates more   --   15(657264-658325) 854344  NP_014816.2 


    ENSEMBL Gene Tree for DCPS (if available)
    TreeFam Gene Tree for DCPS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCPS (see all 841)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440400241,2
    --126171723(+) TTTACC/TTCATG 1 -- us2k10--------
    rs1464362131,2
    C--126171725(+) TACCTC/TATGTA 1 -- us2k10--------
    rs1868877171,2
    --126171872(+) GGCCCC/GACTTC 1 -- us2k10--------
    rs1925339711,2
    --126171902(+) TCTTTC/TTGTTA 1 -- us2k10--------
    rs112204491,2
    C--126171932(+) gggtgC/Tggtgg 1 -- us2k10--------
    rs1839280451,2
    --126171955(+) ATGCCA/TGCTCT 1 -- us2k10--------
    rs1435106501,2
    --126171994(+) GGTCAA/GGAGTT 1 -- us2k10--------
    rs1890193611,2
    --126172036(+) TGACTC/GTACTA 1 -- us2k10--------
    rs285893461,2
    C,F--126172159(+) GATCGC/TGCCAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1929971631,2
    --126172198(+) AGTCTC/TTCCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DCPS (126173647 - 126215644 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DCPS:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663692CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCPS
    DNA2.0 Custom Variant and Variant Library Synthesis for DCPS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610534    OMIM disorders: --

    11 diseases for DCPS:    About MalaCards
    spinal muscular atrophy    vaginitis    muscular atrophy    tonsillitis
    cervicitis    thyroiditis    melanoma    malaria
    cerebritis    prostatitis    endotheliitis


    DCPS for disorders           About GeneDecksing


    Export disorders for DCPS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCPS gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with DCPS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. (PubMed id 14523240)1, 2, 3 van Dijk E.... Seraphin B. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. (PubMed id 12198172)1, 2, 3 Liu H.... Kiledjian M. (EMBO J. 2002)
    3. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PubMed id 12871939)1, 2, 9 Kwasnicka D.A.... Vincent S.R. (J. Biol. Chem. 2003)
    4. Functional analysis of mRNA scavenger decapping enzymes. (PubMed id 15273322)1, 2, 9 Liu S.-W.... Kiledjian M. (RNA 2004)
    5. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PubMed id 16140270)1, 2, 9 Kwasnicka-Crawford D.A. and Vincent S.R. (Biochem. Biophys. Res. Commun. 2005)
    6. Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. (PubMed id 15068804)1, 2, 9 Gu M.... Lima C.D. (Mol. Cell 2004)
    7. Proteomic approach to the identification of novel delta-lactoferrin target genes: Characterization of DcpS, an mRNA scavenger decapping enzyme. (PubMed id 18725266)1, 2 Mariller C....Pierce A. (Biochimie 2009)
    8. DcpS as a therapeutic target for spinal muscular atrophy. (PubMed id 18839960)1, 2 Singh J.... Gurney M.E. (ACS Chem. Biol. 2008)
    9. DcpS scavenger decapping enzyme can modulate pre-mRNA splicing. (PubMed id 18426921)1, 2 Shen V.... Kiledjian M. (RNA 2008)
    10. Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping. (PubMed id 15769464)1, 2 Chen N.... Song H. (J. Mol. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28960 HGNC: 29812 AceView: DCPS Ensembl:ENSG00000110063 euGenes: HUgn28960
    ECgene: DCPS Kegg: 28960 H-InvDB: DCPS

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DCPS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DCPS gene:
    Search GeneIP for patents involving DCPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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