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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCPS Gene

protein-coding   GIFtS: 54
GCID: GC11P126173

decapping enzyme, scavenger
 Explore 4 diseases affiliated with
DCPS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DCPS    

Aliases
for DCPS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Decapping Enzyme, Scavenger1 2     HSPC0151
HINT-51 2 3     Heat Shock-Like Protein 12
HSL11 2     Homolog Of C. Elegans 7meGMP-Directed Hydrolase Dcs-12
Decapping Scavenger Enzyme2 3     M7GpppX Diphosphatase2
Hint-Related 7meGMP-Directed Hydrolase2 3     MRNA Decapping Enzyme2
Histidine Triad Nucleotide-Binding Protein 52 3     DCS13
Histidine Triad Protein Member 52 3     EC 3.6.1.593
Scavenger MRNA-Decapping Enzyme DcpS2 3     HINT53
DCS-12 3     

External Ids:    HGNC: 298121   Entrez Gene: 289602   Ensembl: ENSG000001100637   OMIM: 6105345   UniProtKB: Q96C863   

Export aliases for DCPS gene to outside databases

Previous GC identifers: GC11P128174 GC11P127686 GC11P126207 GC11P125711 GC11P125678 GC11P122121


Summaries
for DCPS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
Function: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation
of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine
nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and
specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog
structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not
hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules
longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May
also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated
decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP.
Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death

Gene Wiki entry for DCPS


Genomic Views
for DCPS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCPS gene promoter:
         USF1   HNF-3beta   Tal-1beta   GATA-1   GATA-2   E47   AREB6   USF-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DCPS promoter sequence
   Search SABiosciences Chromatin IP Primers for DCPS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCPS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.2   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24

DCPS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCPS gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P126173:  view genomic region     (about GC identifiers)

Start:
 126,173,647 bp from pter      End:
 126,215,644 bp from pter
Size:
 41,998 bases      Orientation:
 plus strand

Proteins
for DCPS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86 (See protein sequence)
Recommended Name: m7GpppX diphosphatase  
Size: 337 amino acids; 38609 Da
Subunit: Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and
EXOSC4. Interacts with NDOR1
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling
protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner
6/7 PDB 3D structures from and Proteopedia for DCPS (see all 7):
1ST0 (3D)        1ST4 (3D)        1XML (3D)        1XMM (3D)        3BL7 (3D)        3BL9 (3D)    
Secondary accessions: Q8NHL8 Q9Y2S5

Explore the universe of human proteins at neXtProt for DCPS: NX_Q96C86

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96C86

    • DCPS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_054745.1  
    ENSEMBL proteins: 
     ENSP00000263579  
    Reactome Protein details: Q96C86
    Human Recombinant Protein Products: 
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    Novus Biologicals DCPS Lysate
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    ProSpec Recombinant Protein for DCPS
    Uscn Proteins for DCPS

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA18441014
    GO:0005739mitochondrion IDA--
    GO:0005829cytosol TAS--


    DCPS for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DCPS

    Protein Domains /
    Families
    for DCPS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DCPS for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR008594 DcpS/DCS2
     IPR019808 Histidine_triad_CS
     IPR011146 HIT-like
     IPR011145 Scavenger_mRNA_decap_enz_N

    Graphical View of Domain Structure for InterPro Entry Q96C86

    ProtoNet protein and cluster: Q96C86

    1 Blocks protein family: IPB001310 Histidine triad (HIT) protein

    UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
    Domain: The C-terminal histidine triad (HIT) motif and the N-terminal domain are required for the decapping activity.
    The N-terminus is necessary but not sufficient for binding cap structures
    Similarity: Belongs to the HIT family


    Function
    for DCPS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
    Function: Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation
    of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine
    nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and
    specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog
    structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not
    hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules
    longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May
    also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated
    decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds to m7GpppG and strongly to m7GDP.
    Plays a role in first intron splicing of pre-mRNAs. Inhibits activation-induced cell death
    Catalytic activity: M(7)G5'ppp5'N(3'ppp5'N)(n) + H(2)O = 7-methylguanosine 5'-phosphate + pp5'N(3'ppp5'N)(n)
    Catalytic activity: 7-methylguanosine 5'-diphosphate + H(2)O = 7-methylguanosine 5'-phosphate + phosphate
    Enzyme regulation: The hydrolytic product 7-methylguanosine diphosphate (m7GDP) efficiently inhibits the decapping
    scavenger activity and acts as a competitive inhibitor in vitro. Inhibited by 2,4-diaminoquinazoline
    Induction: Up-regulated by menadione. Up-regulated by the transcription factor LTF isoform delta-lactoferrin (at
    protein level)

    Enzyme Number (IUBMB): EC 3.6.1.591

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for DCPS

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000340RNA 7-methylguanosine cap binding IDA12198172
    GO:0005515protein binding IPI16140270
    GO:0016787hydrolase activity ----
    GO:0050072m7G(5')pppN diphosphatase activity IDA12198172


    DCPS for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Dcps):
     no phenotypic analysis 

    DCPS for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DCPS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism of mRNA
    		Metabolism of mRNA1.00
    		Metabolism of RNA0.92
    2Deadenylation-dependent mRNA decay
    		Deadenylation-dependent mRNA decay1.00
    		RNA degradation0.50
    3Destabilization of mRNA by Tristetraprolin (TTP)
    		mRNA Decay by 3' to 5' Exoribonuclease0.56
    4Generic Transcription Pathway
    		Gene Expression0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for DCPS
        Deadenylation-dependent mRNA decay
    Metabolism of RNA
    Metabolism of mRNA
    Gene Expression
    mRNA Decay by 3' to 5' Exoribonuclease


    1         Kegg Pathway  (Kegg details for DCPS):
        RNA degradation


    DCPS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCPS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for DCPS (Q96C863 ENSP000002635794) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2FP612183, ENSP000004038524I2D: score=5 STRING: ENSP00000403852
    FEN1P397483, ENSP000003054804I2D: score=1 STRING: ENSP00000305480
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    TREHO432803, ENSP000002640294I2D: score=1 STRING: ENSP00000264029
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ----
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000290deadenylation-dependent decapping of nuclear-transcribed mRNA IEA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--


    DCPS for ontologies           About GeneDecksing



    Drugs & Compounds
    for DCPS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DCPS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCPS

    7 DrugBank Compounds for DCPS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    7-Methyl-Gpppa-- --target--17139284 17016423
    7n-Methyl-8-Hydroguanosine-5'-Diphosphate-- --target--17139284 17016423
    Mrna Cap Analog N7-Methyl Gpppg-- --target--17139284 17016423
    N7-Methyl-Guanosine-5'-Monophosphate-- --target--17139284 17016423
    5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine-- --target--10592235
    5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine-- --target--10592235
    5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine-- --target--10592235

    2 Novoseek chemical compound relationships for DCPS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    flavin 64.4 2 16140270 (1), 12871939 (1)
    nadph 41.6 1 12871939 (1)

    Search CenterWatch for drugs/clinical trials and news about DCPS 

    Transcripts
    for DCPS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DCPS gene: 
    NM_014026.3  

    Unigene Cluster for DCPS:

    Decapping enzyme, scavenger
    Hs.504249  [show with all ESTs]
    Unigene Representative Sequence: AK090828
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263579(uc001qdp.3) ENST00000530860 ENST00000529149

    miRNA
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    Clone
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    Additional cDNA sequence: 

    AF077201.1 AF532613.1 AK026554.1 AK090828.1 AK223089.1 AK307403.1 AY040771.1 AY077684.1 
    BC014532.1 

    9 DOTS entries:

    DT.416250  DT.40305809  DT.100737676  DT.95080899  DT.95080903  DT.95080901  DT.95080926  DT.100728418 
    DT.91657226 

    24/151 AceView cDNA sequences (see all 151):

    CB155926 AI674638 BU726067 BP428507 AF532613 BX375089 CR616240 BE382749 
    AY077684 AK090828 CR606807 AA581897 AI827832 BQ023313 NM_014026 AA233083 
    BM794099 CB161771 CB161608 CR607221 AA243865 BM010507 BX341050 BC014532 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DCPS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:                    -     -                 -                           
    SP2:                                            -                           
    SP3:                                            -     -                     
    SP4:                    -     -     -                                       
    SP5:                                                                        


    ECgene alternative splicing isoforms for DCPS

    Expression
    for DCPS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCPS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCACTTCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DCPS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    EyeRetinaEye
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DCPS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCPS

    SOURCE GeneReport for Unigene cluster: Hs.504249

    UniProtKB/Swiss-Prot: DCPS_HUMAN, Q96C86
    Tissue specificity: Detected in liver, brain, kidney, testis and prostate

        SABiosciences Custom PCR Arrays for DCPS
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    In Situ
    Assay Products:     
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    Orthologs
    for DCPS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DCPS gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dcps1 , 5 decapping enzyme, scavenger1, 5 86.37(n)1
    90.15(a)1    		   9 (19.71 cM)5
    693051  NM_027030.21  NP_081306.11 
     351244085 
    chicken
    (Gallus gallus)    		 Aves DCPS1 decapping enzyme, scavenger 68.18(n)
    64.72(a)    		   419716  XM_417859.3  XP_417859.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DCPS6
    		 --
    		 70(a)
    		 1 ↔ 1
    		 GL343322.1(1129449-1158460)
    African clawed frog
    (Xenopus laevis)    		 Amphibia hint5-A2 histidine triad protein member 5 71.42(n)    AY040776.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AF510720.12   -- 73.79(n)    AF510720.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG20911 CG2091 53.68(n)
    44.56(a)    		   40711  NM_141325.2  NP_649582.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea dcs-11 Protein DCS-1 51.35(n)
    42.08(a)    		   180315  NM_075475.2  NP_507876.1 
    A. gossypii yeast
    (Ashbya gossypii)    		 Saccharomycetes AGOS_AGR268W1 AGR268Wp 51.37(n)
    37.69(a)    		   4623236  NM_211996.1  NP_986934.1 


    ENSEMBL Gene Tree for DCPS (if available)
    TreeFam Gene Tree for DCPS (if available) 

    Paralogs
    for DCPS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DCPS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/807 NCBI SNPs in DCPS are shown (see all 807)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1440400241,2
    		--126171723(+) TTTACC/TTCATG 1 -- us2k10--------
    rs1464362131,2
    		--126171725(+) TACCTC/TATGTA 1 -- us2k10--------
    rs1868877171,2
    		--126171872(+) GGCCCC/GACTTC 1 -- us2k10--------
    rs1925339711,2
    		--126171902(+) TCTTTC/TTGTTA 1 -- us2k10--------
    rs112204491,2
    		C,--126171932(+) GGGTGC/TGGTGG 1 -- us2k10--------
    rs1839280451,2
    		--126171955(+) ATGCCA/TGCTCT 1 -- us2k10--------
    rs1435106501,2
    		--126171994(+) GGTCAA/GGAGTT 1 -- us2k10--------
    rs1890193611,2
    		--126172036(+) TGACTC/GTACTA 1 -- us2k10--------
    rs285893461,2
    		C,--126172159(+) GATCGC/TGCCAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1929971631,2
    		--126172198(+) AGTCTC/TTCCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DCPS (126173647 - 126215644 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DCPS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCPS
    DNA2.0 Custom Variant and Variant Library Synthesis for DCPS

    Disorders / Diseases
    for DCPS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DCPS for disorders           About GeneDecksing

    OMIM gene information: 610534    OMIM disorders: --

    4 diseases for DCPS:    About MalaCards
    vaginal neoplasm    pharyngitis    prostatitis    neuronitis


    Export disorders for DCPS gene to outside databases

    Publications
    for DCPS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCPS gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with DCPS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. (PubMed id 14523240)1, 2, 3 van Dijk E....Seraphin B. (2003)
    2. The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. (PubMed id 12198172)1, 2, 3 Liu H.... Kiledjian M. (2002)
    3. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. (PubMed id 12871939)1, 2, 9 Kwasnicka D.A.... Vincent S.R. (2003)
    4. Functional analysis of mRNA scavenger decapping enzymes. (PubMed id 15273322)1, 2, 9 Liu S.-W.... Kiledjian M. (2004)
    5. Role of a novel dual flavin reductase (NR1) and an associated histidine triad protein (DCS-1) in menadione-induced cytotoxicity. (PubMed id 16140270)1, 2, 9 Kwasnicka-Crawford D.A. and Vincent S.R. (2005)
    6. Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. (PubMed id 15068804)1, 2, 9 Gu M.... Lima C.D. (2004)
    7. Proteomic approach to the identification of novel delta-lactoferrin target genes: Characterization of DcpS, an mRNA scavenger decapping enzyme. (PubMed id 18725266)1, 2 Mariller C....Pierce A. (2009)
    8. DcpS scavenger decapping enzyme can modulate pre-mRNA splicing. (PubMed id 18426921)1, 2 Shen V....Kiledjian M. (2008)
    9. Crystal structures of human DcpS in ligand-free and m7GDP-bound forms suggest a dynamic mechanism for scavenger mRNA decapping. (PubMed id 15769464)1, 2 Chen N....Song H. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for DCPS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DCPS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28960 HGNC: 29812 AceView: DCPS Ensembl:ENSG00000110063 euGenes: HUgn28960
    ECgene: DCPS Kegg: 28960 H-InvDB: DCPS

    Other Databases showing DCPS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DCPS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCPS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DCPS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DCPS gene:
    Search GeneIP for patents involving DCPS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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