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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCP2 Gene

protein-coding   GIFtS: 58
GCID: GC05P112340

Decapping MRNA 2

(Previous name: DCP2 decapping enzyme homolog (S. cerevisiae))
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Decapping MRNA 21 2     M(7)GpppN-MRNA Hydrolase1
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 201 2     DCP2 Decapping Enzyme Homolog2
NUDT202 3     M7GpppN-MRNA Hydrolase2
hDpc2 3     EC 3.6.1.623
MRNA-Decapping Enzyme 22 3     Nucleoside Diphosphate-Linked Moiety X Motif 203
DCP2 Decapping Enzyme Homolog (S. Cerevisiae)1     Nudix Motif 203

External Ids:    HGNC: 244521   Entrez Gene: 1672272   Ensembl: ENSG000001727957   OMIM: 6098445   UniProtKB: Q8IU603   
ORGUL members:         
NONCODE14:n410890      

Export aliases for DCP2 gene to outside databases

Previous GC identifers: GC05P112759 GC05P112343 GC05P112388 GC05P107492


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DCP2 Gene:
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of
mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine
cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants
encoding different isoforms have been noted for this gene.(provided by RefSeq, Jun 2011)

GeneCards Summary for DCP2 Gene: 
DCP2 (decapping mRNA 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with DCP2 include non-specific x-linked mental retardation, and mental retardation, and among its related super-pathways are Deadenylation-dependent mRNA decay and Destabilization of mRNA by Tristetraprolin (TTP). GO annotations related to this gene include RNA binding and m7G(5')pppN diphosphatase activity.

UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60
Function: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl
guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for
the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in
replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has
no activity towards a cap structure lacking a RNA moiety

Gene Wiki entry for DCP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCP2 gene promoter:
         CUTL1   POU3F2   CBF-C   GATA-1   CBF-A   c-Myb   TGIF   MRF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.2   Ensembl cytogenetic band:  5q22.2   HGNC cytogenetic band: 5q22

DCP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCP2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P112340:  view genomic region     (about GC identifiers)

Start:
112,312,399 bp from pter      End:
112,357,892 bp from pter
Size:
45,494 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60 (See protein sequence)
Recommended Name: m7GpppN-mRNA hydrolase  
Size: 420 amino acids; 48457 Da
Cofactor: Manganese. Required for highest activity. Can also utilize magnesium ions
Subunit: Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1,
UPF2 and UPF3B. Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts
with EDC4/HEDLS. Interacts with DPC1B, UPF1, UPF2 and UPF3B. Interacts (via N-terminus and C-terminus) with
TRIM21 (via N-terminus and C-terminus). Associates with polysomes. Interacts with LIMD1, WTIP and AJUBA.
Interacts with DDX17 in an RNA-dependent manner. Interacts with ZC3HAV1. Interacts with APOBEC3G in an
RNA-dependent manner
Subcellular location: Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A
minor amount is nuclear
Secondary accessions: C9J778 Q6P2D4 Q7Z5W5 Q8NBG5
Alternative splicing: 2 isoforms:  Q8IU60-1   Q8IU60-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCP2: NX_Q8IU60

Explore proteomics data for DCP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IU60

  • DCP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001229306.1  NP_689837.2  

    ENSEMBL proteins: 
     ENSP00000425770   ENSP00000424982   ENSP00000373715   ENSP00000427198   ENSP00000439797  
    Reactome Protein details: Q8IU60
    Human Recombinant Protein Products for DCP2: 
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    Cloud-Clone Corp. Proteins for DCP2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0016442RISC complex IDA--

    DCP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NUDT: Nudix motif containing

    4 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR007722 mRNA_decapping_BoxA
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q8IU60

    ProtoNet protein and cluster: Q8IU60

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60
    Similarity: Belongs to the Nudix hydrolase family. DCP2 subfamily
    Similarity: Contains 1 nudix hydrolase domain


    DCP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCP2_HUMAN, Q8IU60
    Function: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl
    guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for
    the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in
    replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has
    no activity towards a cap structure lacking a RNA moiety
    Catalytic activity: M(7)G5'ppp5'-mRNA + H(2)O = m(7)GDP + 5'-phospho-mRNA

         Enzyme Number (IUBMB): EC 3.6.1.621

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI12417715
    GO:0016787hydrolase activity ----
    GO:0016896exoribonuclease activity, producing 5'-phosphomonoesters TAS--
    GO:0030145manganese ion binding IEA--
         
    DCP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dcp2):
     normal 

    DCP2 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DCP2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.49
    mRNA Decay by 5' to 3' Exoribonuclease0.31
    RNA degradation0.49
    2Destabilization of mRNA by Tristetraprolin (TTP)
    Destabilization of mRNA by Tristetraprolin (TTP)0.79
    Destabilization of mRNA by KSRP0.56
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.79
    3Metabolism of mRNA
    Metabolism of mRNA0.92
    Metabolism of RNA0.92
    4CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.63
    5Generic Transcription Pathway
    Gene Expression0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/9        Reactome Pathways for DCP2 (see all 9)
        Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
    Deadenylation-dependent mRNA decay
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
    Destabilization of mRNA by Tristetraprolin (TTP)
    Destabilization of mRNA by KSRP


    1         Kegg Pathway  (Kegg details for DCP2):
        RNA degradation


    DCP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DCP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for DCP2 (Q8IU601, 3 ENSP000003737154) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCP1BQ8IZD41, 3, ENSP000002806654EBI-521577,EBI-521595 I2D: score=3 STRING: ENSP00000280665
    UPF1Q929001, 3, ENSP000002628034EBI-521577,EBI-373471 I2D: score=3 STRING: ENSP00000262803
    DCP1AQ9NPI61, 3EBI-521577,EBI-374238 I2D: score=3 
    EDC4Q6P2E91, 3, ENSP000003518114EBI-521577,EBI-1006038 I2D: score=3 STRING: ENSP00000351811
    PSMB1P206183, ENSP000002621934I2D: score=4 STRING: ENSP00000262193
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0006402mRNA catabolic process IDA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    DCP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DCP2

    2 HMDB Compounds for DCP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--

    Search CenterWatch for drugs/clinical trials and news about DCP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCP2 gene (2 alternative transcripts): 
    NM_001242377.1  NM_152624.5  

    Unigene Cluster for DCP2:

    DCP2 decapping enzyme homolog (S. cerevisiae)
    Hs.443875  [show with all ESTs]
    Unigene Representative Sequence: NM_152624
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515408 ENST00000513585 ENST00000389063(uc003kqh.3 uc010jcc.3 uc011cwa.2)
    ENST00000510046 ENST00000504961(uc003kqg.3) ENST00000512751 ENST00000502635
    ENST00000508359 ENST00000543319
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-579 hsa-miR-199a-3p hsa-miR-128 hsa-miR-3622b-3p hsa-miR-1243 hsa-miR-3649 hsa-miR-200b hsa-miR-3909
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    Additional mRNA sequence: 

    AB002445.1 AK025019.1 AK090564.1 AK296361.1 AK311298.1 AY135173.1 AY146650.1 BC017965.1 
    BC045596.1 BC064593.1 BC068042.1 BX537716.1 BX648838.1 NR_038352.1 

    15 DOTS entries:

    DT.315854  DT.100023282  DT.100861344  DT.97842010  DT.407862  DT.75142815  DT.102824852  DT.120847142 
    DT.441438  DT.442533  DT.97824722  DT.100741608  DT.439205  DT.91642318  DT.92426124 

    24/190 AceView cDNA sequences (see all 190):

    AL602056 AL135390 AA044626 AA447169 BX117796 AI879958 AA732011 AA278786 
    CR612463 AA250918 CB146331 AI815658 AI003288 AA831325 AI242959 AA443801 
    AA713944 BQ961493 AA291191 BM678388 BQ214025 BM713473 BG288802 AA830361 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DCP2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
    SP1:                                -     -     -                                                                             -                     
    SP2:                                -     -     -                                                                 -     -     -                     
    SP3:                                -     -     -     -     -     -     -                                   -                                       
    SP4:                                                                                                                                                
    SP5:                                -           -                                                                                                   


    ECgene alternative splicing isoforms for DCP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGAATT
    DCP2 Expression
    About this image


    See DCP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCP2

    SOURCE GeneReport for Unigene cluster: Hs.443875

    UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60
    Tissue specificity: Expressed in brain and testis. Not detected in heart (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DCP2 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcp21 , 5 DCP2 decapping enzyme homolog (S. cerevisiae)1, 5 89.21(n)1
    92.86(a)1
      18 (23.74 cM)5
    706401  NM_027490.11  NP_081766.11 
     443805005 
    chicken
    (Gallus gallus)
    Aves DCP21 DCP2 decapping enzyme homolog (S. cerevisiae) 81.35(n)
    84.9(a)
      769972  XM_003643043.1  XP_003643091.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCP26
    DCP2 decapping enzyme homolog (S. cerevisiae)
    82(a)
    1 ↔ 1
    GL343193.1(7053773-7072012)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87062 Xenopus laevis transcribed sequence with weak similarity more 80.82(n)    BJ029436.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559382 similar to decapping enzyme hDcp2 80.17(n)   393121  BC044547.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dcp26
    Decapping protein 2
    19(a)
    1 ↔ 1
    3L(15811834-15819523)
    worm
    (Caenorhabditis elegans)
    Secernentea dcap-26
    mRNA-decapping enzyme 2
    16(a)
    1 ↔ 1
    IV(13513369-13521872)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCP26
    Catalytic subunit of the Dcp1p-Dcp2p decapping enz...
    12(a)
    1 ↔ 1
    XIV(402652-405564)


    ENSEMBL Gene Tree for DCP2 (if available)
    TreeFam Gene Tree for DCP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1215 SNPs in DCP2 are shown (see all 1215)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709736581,2
    C--107515840(-) TGGGTGTGG/-  
            
    GTGTG
    3 -- int11Minor allele frequency- -:0.00NA 2
    rs356462021,2
    C--112314380(+) AAAAA-/AGGAAA 3 -- int10--------
    rs353388361,2
    C--112316726(+) TTTTTT/-AGAGA 3 -- int11Minor allele frequency- -:0.50NA 2
    rs339959161,2
    C--112317887(+) TAATA-/TATGTCC 3 -- int10--------
    rs3681240321,2
    C--112324191(+) TAATA-/AAAAAAA 3 -- int10--------
    rs3740245501,2
    C--112325126(+) AAAAA-/AAAAAGA 3 -- int10--------
    rs346209851,2
    C--112325625(+) GTGAT-/GATTTGGA 3 -- int10--------
    rs107140921,2
    C--112326581(+) TGTGA-/TTTTTT 3 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs131626421,2
    C--112328598(+) ACTTAC/TTTTTT 3 -- int1 trp30--------
    rs1464799491,2
    C--112328598(+) ACTTA-/CTTTTT 3 -- int11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for DCP2 (112312399 - 112357892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DCP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv882717CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609844    OMIM disorders: --

    3 diseases for DCP2:    About MalaCards
    non-specific x-linked mental retardation    mental retardation    lung cancer

    1 disease from the University of Copenhagen DISEASES database for DCP2:
    non-specific X-linked mental retardation

    DCP2 for disorders           About GeneDecksing


    Export disorders for DCP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCP2 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with DCP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PubMed id 12417715)1, 2, 3 Lykke-Andersen J. (2002)
    2. The hDcp2 protein is a mammalian mRNA decapping enzyme. (PubMed id 12218187)1, 2, 3 Wang Z.... Kiledjian M. (2002)
    3. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2, 9 Wichroski M.J....Rana T.M. (2006)
    4. Multiple mRNA decapping enzymes in mammalian cells. (PubMed id 21070968)1, 2 Song M.G....Kiledjian M. (2010)
    5. SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity. (PubMed id 18361920)1, 2 Yamochi T....Morimoto C. (2008)
    6. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (2008)
    7. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)1, 2 Fenger-Groen M.... Lykke-Andersen J. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Cytoplasmic foci are sites of mRNA decay in human cells. (PubMed id 15067023)1, 2 Cougot N.... Seraphin B. (2004)
    10. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 167227 HGNC: 24452 AceView: DCP2 Ensembl:ENSG00000172795 euGenes: HUgn167227
    ECgene: DCP2 Kegg: 167227 H-InvDB: DCP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCP2 gene:
    Search GeneIP for patents involving DCP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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