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DCP2 Gene

protein-coding   GIFtS: 57
GCID: GC05P112313

Decapping MRNA 2

(Previous name: DCP2 decapping enzyme homolog (S. cerevisiae))
  Search for DCP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Decapping MRNA 21 2     M(7)GpppN-MRNA Hydrolase1
Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 201 2     DCP2 Decapping Enzyme Homolog2
NUDT202 3     M7GpppN-MRNA Hydrolase2
hDpc2 3     EC 3.6.1.623
MRNA-Decapping Enzyme 22 3     Nucleoside Diphosphate-Linked Moiety X Motif 203
DCP2 Decapping Enzyme Homolog (S. Cerevisiae)1     Nudix Motif 203

External Ids:    HGNC: 244521   Entrez Gene: 1672272   Ensembl: ENSG000001727957   OMIM: 6098445   UniProtKB: Q8IU603   

Export aliases for DCP2 gene to outside databases

Previous GC identifers: GC05P112759 GC05P112343 GC05P112388 GC05P112340 GC05P107492


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCP2 Gene:
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of
mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine
cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants
encoding different isoforms have been noted for this gene.(provided by RefSeq, Jun 2011)

GeneCards Summary for DCP2 Gene:
DCP2 (decapping mRNA 2) is a protein-coding gene. GO annotations related to this gene include RNA binding and m7G(5')pppN diphosphatase activity.

UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60
Function: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl
guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for
the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in
replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has
no activity towards a cap structure lacking an RNA moiety

Gene Wiki entry for DCP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCP2 gene promoter:
         CUTL1   POU3F2   CBF-C   GATA-1   CBF-A   c-Myb   TGIF   MRF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCP2 promoter sequence
   Search Chromatin IP Primers for DCP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q22.2   Ensembl cytogenetic band:  5q22.2   HGNC cytogenetic band: 5q22

DCP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCP2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P112313:  view genomic region     (about GC identifiers)

Start:
112,312,399 bp from pter      End:
112,357,892 bp from pter
Size:
45,494 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60 (See protein sequence)
Recommended Name: m7GpppN-mRNA hydrolase  
Size: 420 amino acids; 48457 Da
Cofactor: Manganese. Required for highest activity. Can also utilize magnesium ions
Subunit: Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1,
UPF2 and UPF3B. Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts
with EDC4/HEDLS. Interacts with DPC1B, UPF1, UPF2 and UPF3B. Interacts (via N-terminus and C-terminus) with
TRIM21 (via N-terminus and C-terminus). Associates with polysomes. Interacts with LIMD1, WTIP and AJUBA.
Interacts with DDX17 in an RNA-dependent manner. Interacts with ZC3HAV1. Interacts with APOBEC3G in an
RNA-dependent manner
Secondary accessions: C9J778 Q6P2D4 Q7Z5W5 Q8NBG5
Alternative splicing: 2 isoforms:  Q8IU60-1   Q8IU60-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCP2: NX_Q8IU60

Explore proteomics data for DCP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DCP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229306.1  NP_689837.2  

    ENSEMBL proteins: 
     ENSP00000425770   ENSP00000424982   ENSP00000373715   ENSP00000427198   ENSP00000439797  
    Reactome Protein details: Q8IU60

    DCP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NUDT: Nudix motif containing

    4 InterPro protein domains:
     IPR015797 NUDIX_hydrolase_dom-like
     IPR020084 NUDIX_hydrolase_CS
     IPR007722 mRNA_decapping_BoxA
     IPR000086 NUDIX_hydrolase_dom

    Graphical View of Domain Structure for InterPro Entry Q8IU60

    ProtoNet protein and cluster: Q8IU60

    1 Blocks protein domain: IPB000086 NUDIX hydrolase

    UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60
    Similarity: Belongs to the Nudix hydrolase family. DCP2 subfamily
    Similarity: Contains 1 nudix hydrolase domain


    Find genes that share domains with DCP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCP2_HUMAN, Q8IU60
    Function: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl
    guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for
    the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in
    replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has
    no activity towards a cap structure lacking an RNA moiety
    Catalytic activity: 5'-(N(7)-methylguanosine 5'-triphospho)-(mRNA) + H(2)O = N(7)-methylguanosine 5'-diphosphate +
    5'-phospho-(mRNA)

         Enzyme Number (IUBMB): EC 3.6.1.621

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI12417715
    GO:0016787hydrolase activity ----
    GO:0016896exoribonuclease activity, producing 5'-phosphomonoesters TAS--
    GO:0030145manganese ion binding IEA--
         
    Find genes that share ontologies with DCP2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dcp2):
     normal 

    Find genes that share phenotypes with DCP2           About GenesLikeMe

    Animal Models:
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    Block miRNA regulation of human, mouse, rat DCP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCP2 (see all 137):
    hsa-miR-579 hsa-miR-199a-3p hsa-miR-128 hsa-miR-3622b-3p hsa-miR-1243 hsa-miR-3649 hsa-miR-200b hsa-miR-3909
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCP2_HUMAN, Q8IU60: Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A
    minor amount is nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body IDA--
    GO:0005634nucleus IDA--
    GO:0005829cytosol TAS--
    GO:0016442RISC complex IDA--

    Find genes that share ontologies with DCP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCP2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Destabilization of mRNA by KSRP0.00
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.00
    Destabilization of mRNA by Tristetraprolin (TTP)0.00
    3PERK regulated gene expression
    PERK regulated gene expression0.90
    Activation of Genes by ATF40.90
    4Unfolded Protein Response
    Unfolded Protein Response0.61
    5Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with DCP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5 Reactome Pathways for DCP2
        Tristetraprolin (TTP) destabilizes mRNA
    Butyrate Response Factor 1 (BRF1) destabilizes mRNA
    KSRP destabilizes mRNA
    mRNA decay by 5' to 3' exoribonuclease
    ATF4 activates genes


    1 Kegg Pathway  (Kegg details for DCP2):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCP2
    Interactions:

        GeneGlobe Interaction Network for DCP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCP2 (Q8IU601, 3 ENSP000003737154) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCP1BQ8IZD41, 3, ENSP000002806654EBI-521577,EBI-521595 I2D: score=3 STRING: ENSP00000280665
    UPF1Q929001, 3, ENSP000002628034EBI-521577,EBI-373471 I2D: score=3 STRING: ENSP00000262803
    DCP1AQ9NPI61, 3EBI-521577,EBI-374238 I2D: score=3 
    EDC4Q6P2E91, 3, ENSP000003518114EBI-521577,EBI-1006038 I2D: score=3 STRING: ENSP00000351811
    PSMB1P206183, ENSP000002621934I2D: score=4 STRING: ENSP00000262193
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0006402mRNA catabolic process IDA--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--

    Find genes that share ontologies with DCP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for DCP2

    2 HMDB Compounds for DCP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--
    Manganesemanganese 7439-96-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCP2 gene (2 alternative transcripts): 
    NM_001242377.1  NM_152624.5  

    Unigene Cluster for DCP2:

    DCP2 decapping enzyme homolog (S. cerevisiae)
    Hs.443875  [show with all ESTs]
    Unigene Representative Sequence: NM_152624
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000515408 ENST00000513585 ENST00000389063(uc003kqh.3 uc010jcc.3 uc011cwa.2)
    ENST00000510046 ENST00000504961(uc003kqg.3) ENST00000512751 ENST00000502635
    ENST00000508359 ENST00000543319
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    hsa-miR-579 hsa-miR-199a-3p hsa-miR-128 hsa-miR-3622b-3p hsa-miR-1243 hsa-miR-3649 hsa-miR-200b hsa-miR-3909
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    Additional mRNA sequence: 

    AB002445.1 AK025019.1 AK090564.1 AK296361.1 AK311298.1 AY135173.1 AY146650.1 BC017965.1 
    BC045596.1 BC064593.1 BC068042.1 BX537716.1 BX648838.1 NR_038352.1 

    15 DOTS entries:

    DT.315854  DT.100023282  DT.100861344  DT.97842010  DT.407862  DT.75142815  DT.102824852  DT.120847142 
    DT.441438  DT.442533  DT.97824722  DT.100741608  DT.439205  DT.91642318  DT.92426124 

    Selected AceView cDNA sequences (see all 190):

    AA831325 AA250918 AI879958 BM678388 AA443801 AI242959 AA278786 CB146331 
    AA447169 AI815658 AI193997 AA830361 AL691615 BG288802 BX109702 AI702081 
    BM713473 BQ214025 AL602056 AI695683 CR612463 AA043505 BX117796 AA732011 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCP2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
    SP1:                                -     -     -                                                                             -                     
    SP2:                                -     -     -                                                                 -     -     -                     
    SP3:                                -     -     -     -     -     -     -                                   -                                       
    SP4:                                                                                                                                                
    SP5:                                -           -                                                                                                   


    ECgene alternative splicing isoforms for DCP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTGAATT
    DCP2 Expression
    About this image

    DCP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443875

    UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60
    Tissue specificity: Expressed in brain and testis. Not detected in heart (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DCP2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcp21 , 5 DCP2 decapping enzyme homolog (S. cerevisiae)1, 5 89.21(n)1
    92.86(a)1
      18 (23.74 cM)5
    706401  NM_027490.11  NP_081766.11 
     443805005 
    chicken
    (Gallus gallus)
    Aves DCP21 DCP2 decapping enzyme homolog (S. cerevisiae) 82.16(n)
    85.47(a)
      769972  XM_004949272.1  XP_004949329.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCP26
    decapping mRNA 2
    82(a)
    1 ↔ 1
    GL343193.1(7053773-7072012)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87062 Xenopus laevis transcribed sequence with weak similarity more 80.82(n)    BJ029436.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559382 similar to decapping enzyme hDcp2 80.17(n)   393121  BC044547.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dcp26
    Decapping protein 2
    17(a)
    1 ↔ 1
    3L(15811834-15819523)
    worm
    (Caenorhabditis elegans)
    Secernentea dcap-26
    Protein DCAP-2, isoform b (dcap-2) mRNA, complete ...
    16(a)
    1 ↔ 1
    IV(13513369-13521872) WBGene00003582
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DCP26
    Catalytic subunit of the Dcp1p-Dcp2p decapping enz...
    10(a)
    1 ↔ 1
    XIV(402652-405564) YNL118C


    ENSEMBL Gene Tree for DCP2 (if available)
    TreeFam Gene Tree for DCP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for DCP2 (see all 1215)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs709736581,2
    C--107515840(-) TGGGTGTGG/-  
            
    GTGTG
    3 -- int11Minor allele frequency- -:0.00NA 2
    rs356462021,2
    C--112314380(+) AAAAA-/AGGAAA 3 -- int10--------
    rs353388361,2
    C--112316726(+) TTTTTT/-AGAGA 3 -- int11Minor allele frequency- -:0.50NA 2
    rs339959161,2
    C--112317887(+) TAATA-/TATGTCC 3 -- int10--------
    rs3681240321,2
    C--112324191(+) TAATA-/AAAAAAA 3 -- int10--------
    rs3740245501,2
    C--112325126(+) AAAAA-/AAAAAGA 3 -- int10--------
    rs346209851,2
    C--112325625(+) GTGAT-/GATTTGGA 3 -- int10--------
    rs107140921,2
    C--112326581(+) TGTGA-/TTTTTT 3 -- int1 trp31Minor allele frequency- T:0.00NA 2
    rs131626421,2
    C--112328598(+) ACTTAC/TTTTTT 3 -- int1 trp30--------
    rs1464799491,2
    C--112328598(+) ACTTA-/CTTTTT 3 -- int11Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for DCP2 (112312399 - 112357892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DCP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv882717CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCP2
    DNA2.0 Custom Variant and Variant Library Synthesis for DCP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609844    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DCP2:
    non-specific X-linked mental retardation

    Find genes that share disorders with DCP2           About GenesLikeMe


    Export disorders for DCP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCP2 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with DCP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PubMed id 12417715)1, 2, 3 Lykke-Andersen J. (Mol. Cell. Biol. 2002)
    2. The hDcp2 protein is a mammalian mRNA decapping enzyme. (PubMed id 12218187)1, 2, 3 Wang Z.... Kiledjian M. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2, 9 Wichroski M.J.... Rana T.M. (PLoS Pathog. 2006)
    4. Multiple mRNA decapping enzymes in mammalian cells. (PubMed id 21070968)1, 2 Song M.G.... Kiledjian M. (Mol. Cell 2010)
    5. SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity. (PubMed id 18361920)1, 2 Yamochi T.... Morimoto C. (Biochem. Biophys. Res. Commun. 2008)
    6. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (Genes Dev. 2008)
    7. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)1, 2 Fenger-Groen M.... Lykke-Andersen J. (Mol. Cell 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Cytoplasmic foci are sites of mRNA decay in human cells. (PubMed id 15067023)1, 2 Cougot N.... Seraphin B. (J. Cell Biol. 2004)
    10. A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 167227 HGNC: 24452 AceView: DCP2 Ensembl:ENSG00000172795 euGenes: HUgn167227
    ECgene: DCP2 Kegg: 167227 H-InvDB: DCP2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DCP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DCP2 gene:
    Search GeneIP for patents involving DCP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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