DCP2 Gene
protein-coding GIFtS: 54
GCID: GC05P112340
|
|
DCP2 decapping enzyme homolog (S. cerevisiae)
| |
Aliases
for DCP2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| DCP2 Decapping Enzyme Homolog (S. Cerevisiae)1 2 | | Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 202 | | NUDT201 2 3 | | EC 3.6.1.623 | | HDpc1 | | Nucleoside Diphosphate-Linked Moiety X Motif 203 | | MRNA-Decapping Enzyme 22 3 | | Nudix Motif 203 | | M7GpppN-MRNA Hydrolase2 | | |
| External Ids: | HGNC: 244521 | Entrez Gene: 1672272 | Ensembl: ENSG000001727957 | OMIM: 6098445 | UniProtKB: Q8IU603 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n410890 | |
Export aliases for DCP2 gene to outside databasesPrevious GC identifers: GC05P112759 GC05P112343 GC05P112388 GC05P107492
Summaries
for DCP2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DCP2:
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs,both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structurefrom mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding differentisoforms have been noted for this gene.(provided by RefSeq, Jun 2011)
UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60Function: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methylguanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for thedegradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role inreplication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has noactivity towards a cap structure lacking a RNA moiety
Gene Wiki entry for DCP2
|
Genomic Views
for DCP2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DCP2 gene promoter:
CUTL1 POU3F2 CBF-C GATA-1 CBF-A c-Myb TGIF MRF-2 CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCP2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCP2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q22.2 Ensembl cytogenetic band: 5q22.2 HGNC cytogenetic band: 5q22DCP2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P112340: view genomic region
(about GC identifiers)
Start:
|
112,312,399 bp from pter |
End:
|
112,356,667 bp from pter |
Size:
|
44,269 bases |
Orientation:
|
plus strand |
|
Proteins
for DCP2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60 (See
protein sequence)Recommended Name: m7GpppN-mRNA hydrolase Size: 420 amino acids; 48457 Da
Cofactor: Manganese. Required for highest activity. Can also utilize magnesium ions
Subunit: Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1, UPF2and UPF3B. Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts withEDC4/HEDLS. Interacts with DPC1B, UPF1, UPF2 and UPF3B. Interacts (via N-terminus and C-terminus) with TRIM21 (viaN-terminus and C-terminus). Associates with polysomes. Interacts with LIMD1, WTIP and AJUBA. Interacts with DDX17 inan RNA-dependent manner. Interacts with ZC3HAV1. Interacts with APOBEC3G in an RNA-dependent manner
Subcellular location: Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minoramount is nuclear
Secondary accessions: C9J778 Q6P2D4 Q7Z5W5 Q8NBG5Alternative splicing: 2 isoforms: Q8IU60-1 Q8IU60-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DCP2: NX_Q8IU60
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IU60
DCP2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001229306.1 NP_689837.2
ENSEMBL proteins: ENSP00000425770 ENSP00000424982 ENSP00000373715 ENSP00000427198 ENSP00000439797 Reactome Protein details: Q8IU60
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
DCP2 for ontologies About GeneDecksing
DCP2 Antibody Products:
Assay Products for DCP2: |
Protein
Domains /
Families
for DCP2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCP2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IU60ProtoNet protein and cluster: Q8IU60 1 Blocks protein family: IPB000086 NUDIX hydrolase
UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60Similarity: Belongs to the Nudix hydrolase family. DCP2 subfamilySimilarity: Contains 1 nudix hydrolase domain |
Function
for DCP2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60Function: Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methylguanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for thedegradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role inreplication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has noactivity towards a cap structure lacking a RNA moietyCatalytic activity: M(7)G5'ppp5'-mRNA + H(2)O = m(7)GDP + 5'-phospho-mRNAEnzyme Number (IUBMB): EC 3.6.1.621
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for DCP2 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCP2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCP2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
DCP2 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Dcp2):
DCP2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DCP2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | | | 2 | Destabilization of mRNA by Tristetraprolin (TTP) | | | 3 | Metabolism of mRNA | | | 4 | Ubiquitinated Orc1 is degraded by the proteasome | | | 5 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 
Reactome Pathways for DCP2 (see all 9)
1 
Kegg Pathway (Kegg details for DCP2):
DCP2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DCP2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/40 Interacting proteins for DCP2 (Q8IU601, 3 ENSP000003737154) via UniProtKB, MINT, STRING, and/or I2D (see all 40)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| DCP1B | Q8IZD41, 3, ENSP000002806654 | EBI-521577,EBI-521595 I2D:
score=3 STRING: ENSP00000280665 | | UPF1 | Q929001, 3, ENSP000002628034 | EBI-521577,EBI-373471 I2D:
score=3 STRING: ENSP00000262803 | | DCP1A | Q9NPI61, 3 | EBI-521577,EBI-374238 I2D:
score=3 | | EDC4 | Q6P2E91, 3, ENSP000003518114 | EBI-521577,EBI-1006038 I2D:
score=3 STRING: ENSP00000351811 | | PSMB1 | P206183, ENSP000002621934 | I2D:
score=4 STRING: ENSP00000262193 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
IMP | -- | | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0006402 | mRNA catabolic process |
IDA | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0016070 | RNA metabolic process |
TAS | -- |
DCP2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DCP2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCP2
2 HMDB Compounds for DCP2 About this table
Search CenterWatch for drugs/clinical trials and news about DCP2
|
Transcripts
for DCP2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCP2 gene (2 alternative transcripts): NM_001242377.1 NM_152624.5 Unigene Cluster for DCP2: DCP2 decapping enzyme homolog (S. cerevisiae) Hs.443875 [show with all ESTs]Unigene Representative Sequence: NM_1526249 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000515408 ENST00000513585 ENST00000389063(uc003kqh.3 uc010jcc.3 uc011cwa.2)
ENST00000510046 ENST00000504961(uc003kqg.3) ENST00000512751 ENST00000502635
ENST00000508359 ENST00000543319
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCP2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCP2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for DCP2 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCP2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCP2 |
Additional cDNA sequence: AB002445.1 AK025019.1 AK090564.1 AK296361.1 AK311298.1 AY135173.1 AY146650.1 BC017965.1 BC045596.1 BC064593.1 BC068042.1 BX537716.1 BX648838.1 NR_038352.1 15 DOTS entries: DT.315854 DT.100023282 DT.100861344 DT.97842010 DT.407862 DT.75142815 DT.102824852 DT.120847142 DT.441438 DT.442533 DT.97824722 DT.100741608 DT.439205 DT.91642318 DT.92426124 24/190 AceView cDNA sequences (see all 190): BM678388 AA713944 AI242959 BG288802 AI702081 BQ961493 AI468415 AA043505 AA250918 AA443801 AA291191 AI879958 AL691615 AA831325 AA732011 CR612463 AI815658 AA278786 AI193997 AA629742 AL602056 AI695683 AA044626 AA282442
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DCP2 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14a | · | 14b |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DCP2
|
Expression
for DCP2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGTGAATT
About this image
See DCP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCP2
SOURCE GeneReport for Unigene cluster: Hs.443875
UniProtKB/Swiss-Prot: DCP2_HUMAN, Q8IU60Tissue specificity: Expressed in brain and testis. Not detected in heart (at protein level)
SABiosciences Custom PCR Arrays for DCP2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCP2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCP2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP2 |
Orthologs
for DCP2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DCP2 gene from 9/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Dcp21 , 5 |
DCP2 decapping enzyme homolog (S. cerevisiae)1, 5 |
89.21(n)1
92.86(a)1 |
|
18 (23.74 cM)5
706401 NM_027490.11 NP_081766.11
443805005 |
chicken
(Gallus gallus) |
Aves |
DCP21 |
DCP2 decapping enzyme homolog (S. cerevisiae) |
81.35(n)
84.9(a) |
|
769972 XM_003643043.1 XP_003643091.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DCP26 |
-- |
81(a) |
1 ↔ 1 |
GL343193.1(7053885-7072012) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.87062 |
Xenopus laevis transcribed sequence with weak similarity more |
80.82(n) |
|
BJ029436.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc559382 |
similar to decapping enzyme hDcp2 |
80.17(n) |
|
393121 BC044547.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Dcp26 |
Decapping protein 2 |
19(a) |
1 ↔ 1 |
3L(15811834-15819523) |
worm
(Caenorhabditis elegans) |
Secernentea |
dcap-26 |
mRNA-decapping enzyme 2 |
15(a) |
1 ↔ 1 |
IV(13513345-13521848) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
DCP26 |
mRNA-decapping enzyme subunit 2 |
27(a) |
1 ↔ 1 |
5(4367299-4370265) |
rice
(Oryza sativa) |
Liliopsida |
-- |
hydrolase, NUDIX family, domain containing protein... |
31(a) |
1 ↔ 1 |
2(34372762-34376238) |
ENSEMBL Gene Tree for DCP2 (if available)
TreeFam Gene Tree for DCP2 (if available) |
Paralogs
for DCP2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DCP2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCP2 (112312399 - 112356667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DCP2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCP2 |
|
Disorders
/ Diseases
for DCP2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DCP2 for disorders About GeneDecksing
OMIM gene information: 609844
OMIM disorders: --
2  diseases for DCP2: About MalaCardslung cancer malaria
1 disease from the University of Copenhagen DISEASES database for DCP2:non-specific X-linked mental retardation Export disorders for DCP2 gene to outside databases
|
Publications
for DCP2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCP2 gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with DCP2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PubMed id 12417715)1, 2, 3 Lykke-Andersen J. (2002)
- The hDcp2 protein is a mammalian mRNA decapping enzyme. (PubMed id 12218187)1, 2, 3 Wang Z.... Kiledjian M. (2002)
- Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PubMed id 16699599)1, 2, 9 Wichroski M.J....Rana T.M. (2006)
- Multiple mRNA decapping enzymes in mammalian cells. (PubMed id 21070968)1, 2 Song M.G....Kiledjian M. (2010)
- SSA/Ro52 autoantigen interacts with Dcp2 to enhance its decapping activity. (PubMed id 18361920)1, 2 Yamochi T....Morimoto C. (2008)
- Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (2008)
- Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)1, 2 Fenger-Groen M.... Lykke-Andersen J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cytoplasmic foci are sites of mRNA decay in human cells. (PubMed id 15067023)1, 2 Cougot N.... Seraphin B. (2004)
- A protein interaction framework for human mRNA degradation. (PubMed id 15231747)1, 2 Lehner B. and Sanderson C.M. (2004)
|
External Searches for DCP2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCP2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing DCP2 gene
(According to HUGE)
About This Section
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Specialized Databases showing DCP2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for DCP2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for DCP2 gene:
Search GeneIP for patents involving DCP2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DCP2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for DCP2 | | OriGene shRNA RFP for DCP2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCP2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCP2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DCP2 | | OriGene 3'-UTR Clone for DCP2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCP2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCP2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DCP2 | | OriGene Custom Protein Services for DCP2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCP2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCP2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCP2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCP2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCP2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCP2 |
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| | | | Search Tocris compounds for DCP2 |
| |  |  |  |  | | | | |
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 | | | DCP2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP2 |
|  |  |  | | | | ThermoFisher Antibody for DCP2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCP2 |
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Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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