DCP1B Gene
protein-coding GIFtS: 54
GCID: GC12M002055
|
|
DCP1 decapping enzyme homolog B (S. cerevisiae)
| |
Aliases
for DCP1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DCP1 Decapping Enzyme Homolog B (S. Cerevisiae)1 2 | | HDcp1b1 | | DCP12 5 | | MRNA-Decapping Enzyme 1B2 | | FLJ316381 | | EC 3.-.-.-3 | | Decapping Enzyme HDcp1b2 | | |
Export aliases for DCP1B gene to outside databasesPrevious GC identifers: GC12M001940 GC12M001925 |
Summaries
for DCP1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DCP1B:
DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen,2002 (PubMed 12417715)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: DCP1B_HUMAN, Q8IZD4Function: May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNAdecay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragmentand 7m-GDP (By similarity)
Gene Wiki entry for DCP1B
|
Genomic Views
for DCP1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DCP1B gene promoter:
SRF USF1 NF-1 SRF (504 AA) Tal-1beta C/EBPalpha PPAR-gamma1 USF-1 PPAR-gamma2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCP1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCP1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.33 Ensembl cytogenetic band: 12p13.33 HGNC cytogenetic band: 12p13.33DCP1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M002055: view genomic region
(about GC identifiers)
Start:
|
2,055,214 bp from pter |
End:
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2,113,701 bp from pter |
Size:
|
58,488 bases |
Orientation:
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minus strand |
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Proteins
for DCP1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCP1B_HUMAN, Q8IZD4 (See
protein sequence)Recommended Name: mRNA-decapping enzyme 1B Size: 617 amino acids; 67723 Da
Subunit: Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6
Subcellular location: Cytoplasm. Nucleus (By similarity)
Sequence caution: Sequence=AAH15368.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q86XH9 Q96BP8 Q96MZ8Explore the universe of human proteins at neXtProt for DCP1B: NX_Q8IZD4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZD4
DCP1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689853.3
ENSEMBL proteins: ENSP00000280665 ENSP00000445011 ENSP00000444374 ENSP00000438872 ENSP00000445923 ENSP00000380358 Reactome Protein details: Q8IZD4
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
DCP1B for ontologies About GeneDecksing
DCP1B Antibody Products:
Assay Products for DCP1B: |
Protein
Domains /
Families
for DCP1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCP1B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZD4ProtoNet protein and cluster: Q8IZD4 UniProtKB/Swiss-Prot: DCP1B_HUMAN, Q8IZD4Similarity: Belongs to the DCP1 family |
Function
for DCP1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DCP1B_HUMAN, Q8IZD4Function: May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNAdecay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragmentand 7m-GDP (By similarity)Enzyme Number (IUBMB): EC 3.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCP1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCP1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for DCP1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCP1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP1B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
DCP1B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for DCP1B:
|
Pathways & Interactions
for DCP1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | | | 2 | Metabolism of mRNA | | | 3 | Generic Transcription Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for DCP1B
1 
Kegg Pathway (Kegg details for DCP1B):
DCP1B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCP1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 19)
5/25 Interacting proteins for DCP1B (Q8IZD41, 2, 3 ENSP000002806654) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
IEA | -- | | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0016070 | RNA metabolic process |
TAS | -- | | GO:0016071 | mRNA metabolic process |
TAS | -- |
DCP1B for ontologies About GeneDecksing
|
Drugs & Compounds
for DCP1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCP1B
Search CenterWatch for drugs/clinical trials and news about DCP1B
|
Transcripts
for DCP1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCP1B gene: NM_152640.3 Unigene Cluster for DCP1B: DCP1 decapping enzyme homolog B (S. cerevisiae) Hs.130934 [show with all ESTs]Unigene Representative Sequence: AK2992038 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000280665(uc001qjx.1) ENST00000543381 ENST00000540622 ENST00000536665
ENST00000541700 ENST00000537725 ENST00000535873(uc010sdz.2) ENST00000397173(uc010sdy.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCP1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCP1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCP1B (NM_152640) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCP1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCP1B |
Additional cDNA sequence: AK056200.1 AK299203.1 AK301109.1 AK310475.1 AY146652.1 BC015368.2 BC043437.2 9 DOTS entries: DT.451539 DT.100784389 DT.100807002 DT.121114529 DT.95374560 DT.97776015 DT.40216516 DT.40297724 DT.92006732 24/130 AceView cDNA sequences (see all 130): AI962917 CD637921 AA065252 AI499216 BU739225 BM772167 AA332879 AW189082 CR596230 BQ944757 BQ773904 CR620785 AA233708 BI914698 AA331641 BU179648 BM717663 BU682803 BQ003261 BM772122 AI597988 NM_152640 BX094149 AI799924
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DCP1B (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DCP1B
|
Expression
for DCP1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCP1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGAGTGTTG
About this image
See DCP1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCP1B
SOURCE GeneReport for Unigene cluster: Hs.130934
SABiosciences Custom PCR Arrays for DCP1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCP1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCP1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP1B |
Orthologs
for DCP1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DCP1B gene from 8/22 species (see all 22) About this table
ENSEMBL Gene Tree for DCP1B (if available)
TreeFam Gene Tree for DCP1B (if available) |
Paralogs
for DCP1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DCP1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCP1B (2055214 - 2113701 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DCP1B: --
Human Gene Mutation Database (HGMD): DCP1B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCP1B |
|
Disorders
/ Diseases
for DCP1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DCP1B for disorders About GeneDecksing
OMIM gene information: 609843
OMIM disorders: --
1  disease for DCP1B: About MalaCardsneuronitis
Export disorders for DCP1B gene to outside databases
|
Publications
for DCP1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCP1B gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with DCP1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cytoplasmic foci are sites of mRNA decay in human cells. (PubMed id 15067023)1, 2, 3 Cougot N.... Seraphin B. (2004)
- Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PubMed id 12417715)1, 2, 3 Lykke-Andersen J. (2002)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. (PubMed id 22142827)1 Innocenti F....Ratain M.J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Retroviral GAG proteins recruit AGO2 on viral RNAs wit hout affecting RNA accumulation and translation. (PubMed id 21948796)1 Bouttier M....Lecellier C.H. (2012)
- Identification and characterization of protein intera ctions in the mammalian mRNA processing body using a novel two-hybrid assay. (PubMed id 21672539)1 Bloch D.B....Yang W.H. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for DCP1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCP1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCP1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCP1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCP1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCP1B gene:
Search GeneIP for patents involving DCP1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCP1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCP1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCP1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCP1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCP1B |
| |
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| |  |  |  |  | | | | |
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 | | | DCP1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP1B |
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