Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DCP1B Gene

protein-coding   GIFtS: 58
GCID: GC12M002055

Decapping MRNA 1B

(Previous name: DCP1 decapping enzyme homolog B (S. cerevisiae))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Decapping MRNA 1B1 2     Decapping Enzyme HDcp1b2
DCP12 5     hDcp1b2
DCP1 Decapping Enzyme Homolog B (S. Cerevisiae)1     MRNA-Decapping Enzyme 1B2
DCP1 Decapping Enzyme Homolog B2     EC 3.-.-.-3

External Ids:    HGNC: 244511   Entrez Gene: 1965132   Ensembl: ENSG000001510657   OMIM: 6098435   UniProtKB: Q8IZD43   

Export aliases for DCP1B gene to outside databases

Previous GC identifers: GC12M001940 GC12M001925


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DCP1B Gene:
DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay
(Lykke-Andersen, 2002 (PubMed 12417715)).(supplied by OMIM, Mar 2008)

GeneCards Summary for DCP1B Gene:
DCP1B (decapping mRNA 1B) is a protein-coding gene. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is DCP1A.

UniProtKB/Swiss-Prot: DCP1B_HUMAN, Q8IZD4
Function: May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA
decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA
fragment and 7m-GDP (By similarity)

Gene Wiki entry for DCP1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCP1B gene promoter:
         SRF   USF1   NF-1   SRF (504 AA)   Tal-1beta   C/EBPalpha   PPAR-gamma1   USF-1   PPAR-gamma2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCP1B promoter sequence
   Search Chromatin IP Primers for DCP1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCP1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.33   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13.33

DCP1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCP1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M002055:  view genomic region     (about GC identifiers)

Start:
2,055,214 bp from pter      End:
2,113,701 bp from pter
Size:
58,488 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DCP1B_HUMAN, Q8IZD4 (See protein sequence)
Recommended Name: mRNA-decapping enzyme 1B  
Size: 617 amino acids; 67723 Da
Subunit: Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and
CNOT6
Sequence caution: Sequence=AAH15368.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q86XH9 Q96BP8 Q96MZ8

Explore the universe of human proteins at neXtProt for DCP1B: NX_Q8IZD4

Explore proteomics data for DCP1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys12
  • Modification sites at PhosphoSitePlus

  • See DCP1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689853.3  
    ENSEMBL proteins: 
     ENSP00000280665   ENSP00000445011   ENSP00000444374   ENSP00000380358  
    Reactome Protein details: Q8IZD4

    DCP1B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DCP1B
    OriGene Protein Over-expression Lysate for DCP1B
    OriGene MassSpec for DCP1B
    OriGene Custom Protein Services for DCP1B
    GenScript Custom Purified and Recombinant Proteins Services for DCP1B
    Novus Biologicals DCP1B Protein
    Novus Biologicals DCP1B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCP1B

     
    Search eBioscience for Proteins for DCP1B 

     
    antibodies-online proteins for DCP1B (3 products) 

     
    antibodies-online peptides for DCP1B

    DCP1B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DCP1B
    Novus Biologicals DCP1B Antibodies
    Abcam antibodies for DCP1B
    Cloud-Clone Corp. Antibodies for DCP1B
    ThermoFisher Antibodies for DCP1B
    antibodies-online antibodies for DCP1B (18 products) 

    DCP1B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DCP1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DCP1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DCP1B
    Cloud-Clone Corp. CLIAs for DCP1B
    Search eBioscience for ELISAs for DCP1B 
    antibodies-online kits for DCP1B (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR010334 DCP1

    Graphical View of Domain Structure for InterPro Entry Q8IZD4

    ProtoNet protein and cluster: Q8IZD4

    UniProtKB/Swiss-Prot: DCP1B_HUMAN, Q8IZD4
    Similarity: Belongs to the DCP1 family


    Find genes that share domains with DCP1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCP1B_HUMAN, Q8IZD4
    Function: May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA
    decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA
    fragment and 7m-GDP (By similarity)

         Enzyme Number (IUBMB): EC 3.-.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15231747
    GO:0016787hydrolase activity IEA--
         
    Find genes that share ontologies with DCP1B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DCP1B:
     G2 arrest  Increased G2M DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DCP1B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DCP1B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DCP1B:
    hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmidDCP1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DCP1B
    Predesigned siRNA for gene silencing in human, mouse, rat DCP1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DCP1B

    Clone
    Products:
         
    OriGene clones in human, mouse for DCP1B (see all 6)
    OriGene ORF clones in mouse, rat for DCP1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCP1B (NM_152640)
    Sino Biological Human cDNA Clone for DCP1B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCP1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCP1B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DCP1B
    Browse ESI BIO Cell Lines and PureStem Progenitors for DCP1B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DCP1B_HUMAN, Q8IZD4: Cytoplasm. Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with DCP1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DCP1B About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with DCP1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for DCP1B
        mRNA decay by 5' to 3' exoribonuclease


    1 Kegg Pathway  (Kegg details for DCP1B):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCP1B
    Interactions:

        Search GeneGlobe Interaction Network for DCP1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCP1B (Q8IZD41, 2, 3 ENSP000002806654) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000234258P349313, ENSP000003964864I2D: score=1 STRING: ENSP00000396486
    ENSG00000206383P349313I2D: score=1 
    ENSG00000236251P349313I2D: score=1 
    HSPA1LP349313I2D: score=1 
    DCP2Q8IU601, 3, ENSP000003737154EBI-521595,EBI-521577 I2D: score=3 STRING: ENSP00000373715
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    Find genes that share ontologies with DCP1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCP1B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DCP1B gene: 
    NM_152640.3  

    Unigene Cluster for DCP1B:

    DCP1 decapping enzyme homolog B (S. cerevisiae)
    Hs.130934  [show with all ESTs]
    Unigene Representative Sequence: AK299203
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280665(uc001qjx.1) ENST00000543381 ENST00000540622 ENST00000536665
    ENST00000541700 ENST00000537725 ENST00000535873(uc010sdz.2) ENST00000397173(uc010sdy.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DCP1B using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate DCP1B:
    hsa-miR-494
    SwitchGear 3'UTR luciferase reporter plasmidDCP1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DCP1B
    Predesigned siRNA for gene silencing in human, mouse, rat DCP1B
    Clone
    Products:
         
    OriGene clones in human, mouse for DCP1B (see all 6)
    OriGene ORF clones in mouse, rat for DCP1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCP1B (NM_152640)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCP1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCP1B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DCP1B
    OriGene qSTAR qPCR primer pairs in human, mouse for DCP1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCP1B
      QuantiTect SYBR Green Assays in human, mouse, rat DCP1B
      QuantiFast Probe-based Assays in human, mouse, rat DCP1B

    Additional mRNA sequence: 

    AK056200.1 AK299203.1 AK301109.1 AK310475.1 AY146652.1 BC015368.2 BC043437.2 

    9 DOTS entries:

    DT.451539  DT.100784389  DT.100807002  DT.121114529  DT.95374560  DT.97776015  DT.40216516  DT.40297724 
    DT.92006732 

    Selected AceView cDNA sequences (see all 130):

    BQ773904 AA065252 BI914698 AA331641 AA332879 CR620785 BQ003261 BM717663 
    CR596230 BM772167 CD637921 BU739225 BQ944757 BX094149 AI962917 AI597988 
    AW189082 BU179648 AI499216 AA233708 BU682803 NM_152640 BM772122 AL523591 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCP1B (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -                 -           -                                             
    SP2:                                -           -                                             
    SP3:                                -           -                                             
    SP4:                                                                                          
    SP5:              -                                                                           


    ECgene alternative splicing isoforms for DCP1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DCP1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAGTGTTG
    DCP1B Expression
    About this image

    DCP1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCP1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.130934
        Custom PCR Arrays for DCP1B
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DCP1B
    OriGene qSTAR qPCR primer pairs in human, mouse for DCP1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCP1B
    QuantiTect SYBR Green Assays in human, mouse, rat DCP1B
    QuantiFast Probe-based Assays in human, mouse, rat DCP1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DCP1B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcp1b1 , 5 DCP1 decapping enzyme homolog b (S. cerevisiae)5
    DCP1 decapping enzyme homolog B (S. cerevisiae)1
    76.2(n)1
    67.94(a)1
      6 (56.55 cM)5
    3196181  NM_001033379.31  NP_001028551.21 
     1191752525 
    chicken
    (Gallus gallus)
    Aves DCP1B1 DCP1 decapping enzyme homolog B (S. cerevisiae) 74.02(n)
    73.63(a)
      772197  XM_004937947.1  XP_004938004.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCP1B6
    decapping mRNA 1B
    66(a)
    1 ↔ 1
    5(756937-772273)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dcp1b1 decapping mRNA 1B 63.59(n)
    62.48(a)
      100488205  XM_002938103.2  XP_002938149.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dcp1b1 DCP1 decapping enzyme homolog B (S. cerevisiae) 58.27(n)
    58.43(a)
      568176  NM_001045155.2  NP_001038620.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dcp16
    Decapping protein 1
    32(a)
    1 → many
    2R(19776465-19777788)
    worm
    (Caenorhabditis elegans)
    Secernentea dcap-16
    Protein DCAP-1 (dcap-1) mRNA, complete cds
    25(a)
    1 → many
    IV(1052511-1054794) WBGene00021929


    ENSEMBL Gene Tree for DCP1B (if available)
    TreeFam Gene Tree for DCP1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DCP1B gene
    DCP1A2  

    Find genes that share paralogs with DCP1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DCP1B (see all 1272)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476948931,2
    C--2054789(+) ACTTGA/GAACCA 1 -- int10--------
    rs1852466801,2
    --2054808(+) GTCCAC/TTAATG 1 -- int10--------
    rs1424746151,2
    --2054854(+) CCAGGA/GAATAC 1 -- int10--------
    rs1467320531,2
    --2054904(+) GGGGCA/GTGGAT 1 -- int10--------
    rs1479368141,2
    C--2055058(+) GTGGGA/GGACTA 1 -- int10--------
    rs1884963401,2
    --2055171(+) CTGTAA/CATGTA 1 -- int10--------
    rs2002569131,2
    C--2055261(+) CATAC-/TTTTTT 1 -- ut310--------
    rs72221,2
    C,F,O,A,H--2055266(-) TAAAAG/AAAAAG 1 -- ut31 trp315Minor allele frequency- A:0.47MN NS EA NA WA CSA 975
    rs2015140791,2
    C--2055270(+) TTTTT-/AAAAAA 1 -- ut310--------
    rs24291791,2
    F,A--2055271(+) TTTTTA/TAAAAA 1 -- ut311Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for DCP1B (2055214 - 2113701 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DCP1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661228CNV Deletion23128226
    nsv574CNV Insertion18451855
    esv273343CNV Insertion20981092
    esv271845CNV Insertion20981092
    nsv898600CNV Loss21882294
    nsv525455CNV Loss19592680
    nsv521838CNV Gain19592680
    nsv898598CNV Gain21882294

    Human Gene Mutation Database (HGMD): DCP1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCP1B
    DNA2.0 Custom Variant and Variant Library Synthesis for DCP1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609843    OMIM disorders: --


    Find genes that share disorders with DCP1B           About GenesLikeMe

    Genetic Association Database (GAD): DCP1B

    Export disorders for DCP1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DCP1B gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with DCP1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cytoplasmic foci are sites of mRNA decay in human cells. (PubMed id 15067023)1, 2, 3 Cougot N.... Seraphin B. (J. Cell Biol. 2004)
    2. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PubMed id 12417715)1, 2, 3 Lykke-Andersen J. (Mol. Cell. Biol. 2002)
    3. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. (PubMed id 22142827)1, 4 Innocenti F....Ratain M.J. (Clin. Cancer Res. 2012)
    4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PubMed id 23453885)1 (Lancet 2013)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 196513 HGNC: 24451 AceView: DCP1B Ensembl:ENSG00000151065 euGenes: HUgn196513
    ECgene: DCP1B Kegg: 196513 H-InvDB: DCP1B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DCP1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DCP1B gene:
    Search GeneIP for patents involving DCP1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DCP1B  
     OriGene qPCR primer pairs and template standards for DCP1B   OriGene Protein Over-expression Lysate for DCP1B  
     OriGene MassSpec for DCP1B   OriGene clones in human, mouse for DCP1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for DCP1B   OriGene Purified Protein for DCP1B  
     OriGene ORF clones in mouse, rat for DCP1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DCP1B   OriGene Custom Protein Services for DCP1B  

     
     
     Block miRNA regulation of human, mouse, rat DCP1B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DCP1B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCP1B Predesigned siRNA for gene silencing in human, mouse, rat DCP1B
     QuantiFast Probe-based Assays in human, mouse, rat DCP1B QuantiTect SYBR Green Assays in human, mouse, rat DCP1B
     Custom PCR Arrays for DCP1B Search Chromatin IP Primers for DCP1B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCP1B  Search GeneGlobe Interaction Network for DCP1B
     Regulatory tfbs in DCP1B promoter
     GenScript Custom Purified and Recombinant Proteins Services for DCP1B GenScript cDNA clones with any tag delivered in your preferred vector for DCP1B
     GenScript Custom Assay Services for DCP1B GenScript Custom overexpressing Cell Line Services for DCP1B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DCP1B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DCP1B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DCP1B antibodies
     DCP1B proteins
     DCP1B lysates
     Antibodies for DCP1B
     See all of Abcam's Antibodies, Kits and Proteins for DCP1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DCP1B
     Antibodies for DCP1B
     ELISAs for DCP1B
     CLIAs for DCP1B



     Browse ESI BIO Cell Lines and PureStem Progenitors for DCP1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP1B
     SwitchGear 3'UTR luciferase reporter plasmids for DCP1B
     SwitchGear Promoter luciferase reporter plasmids for DCP1B
     ThermoFisher Antibodies for DCP1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCP1B
     Browse compounds at ApexBio
     Search Addgene for plasmids for DCP1B
      Search eBioscience for proteins for DCP1B
      Search eBioscience for elisas for DCP1B
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for DCP1B
     antibodies-online antibodies for DCP1B (18 products)
     antibodies-online kits for DCP1B (6 products)
     antibodies-online peptides for DCP1B
     antibodies-online proteins for DCP1B (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DCP1B gene at Home site.
    Version: 3.12.248 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4